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In vitro interactions of proton pump inhibitors and azoles against pathogenic fungi
DiscussionThe results suggested that PPIs combined with azoles has the potential to enhance the susceptibilities of azoles against multiple pathogenic fungi and could be a promising strategy to overcome azole resistance issues. However, further investigations are warranted to study the combinational efficacy in more isolates and more species, to investigate the underlying mechanism of interaction and to evaluate the potential for concomitant use of these agents in human. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 17, 2024 Category: Microbiology Source Type: research

Pyrosequencing analysis of bacterial community changes in dental unit waterlines after chlorogenic acid treatment
This study aimed to investigate the potential of chlorogenic acid, a natural substance with broadspectrum antibacterial properties, for treating DUWLs. Over a period of three months, we analyzed the microbial communities in 149 DUWLs samples collected from 5 dental units using high-throughput pyrophosphate sequencing. ResultsThe results revealed that chlorogenic acid treatment had a significant impact on the microbial community profile in the DUWLs, with the most significant changes occurring within the first 15 days and stabilization observed in the last 30 days. The predominant genera detected in the samples were Bactero...
Source: Frontiers in cellular and infection microbiology - January 17, 2024 Category: Microbiology Source Type: research

Microbiota signatures associated with invasive Candida albicans infection in the gastrointestinal tract of immunodeficient mice
In this study, we utilized an immunodeficient Rag2γc (Rag2-/-il2γc-/-) mouse model to investigate the gut microbiota alterations caused by C. albicans throughout its cycle, from its introduction into the gastrointestinal tract to invasion, in the absence of antibiotics. We observed a significant increase in the abundance of Firmicutes, particularly Lachnospiraceae and Ruminococcaceae, as well as a significant decrease in the abundance of Candidatus Arthromitus in mice exposed to either the wild-type SC5314 strain or the filamentation-defective mutant (cph1/cph1 efg1/efg1) HLC54 strain of C. albicans. However, only the SC...
Source: Frontiers in cellular and infection microbiology - January 17, 2024 Category: Microbiology Source Type: research

Resistance against two lytic phage variants attenuates virulence and antibiotic resistance in Pseudomonas aeruginosa
ConclusionsWe show as well that phage resistance impacts virulence factor production. Specifically, phage resistance led to decreased biofilm formation, swarming, and type III secretion; therefore, the virulence towards Galleria mellonella was dramatically attenuated. Furthermore, antibiotic resistance decreased for one clinical strain. Our study highlights important potential advantages of phage therapy’s evolutionary impact that may be exploited to generate robust therapy schemes. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 17, 2024 Category: Microbiology Source Type: research

Corrigendum: Revisiting bacterial cytolethal distending toxin structure and function
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 16, 2024 Category: Microbiology Source Type: research