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Editorial: Precision medicine and immune monitoring for infectious diseases
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 15, 2024 Category: Microbiology Source Type: research

What can we learn from treatments of oral lichen planus?
Oral lichen planus (OLP), a T-lymphocyte-mediated disease of the oral mucosa, has a complex pathogenesis that involves a number of factors. The disease is characterized by recurrent episodes and requires continuous follow up, and there is no curative treatment available. Erosive lichen planus, among others, has a risk of malignant transformation and requires standardized treatment to control its progression. Different clinical subtypes of oral lichen planus require appropriate treatment. Pharmacological treatments are the most widely available and have the greatest variety of options and a number of novel pharmacological t...
Source: Frontiers in cellular and infection microbiology - February 15, 2024 Category: Microbiology Source Type: research

Bibliometric analysis of intestinal microbiota and lung diseases
ConclusionThe correlation and underlying mechanisms between intestinal microbiota and lung diseases, including asthma, COPD, lung cancer, and respiratory infections, remain hot topics in research. However, understanding the mechanisms involving the gut-lung axis is still in its infancy and requires further elucidation. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 15, 2024 Category: Microbiology Source Type: research

Risk of hepatitis B virus reactivation and its effect on survival in advanced hepatocellular carcinoma patients treated with hepatic arterial infusion chemotherapy and lenvatinib plus programmed death receptor-1 inhibitors
ConclusionHBV reactivation may occur in HCC patients treated with HAIC and lenvatinib plus PD1s. Patients with HBV reactivation had shorter survival time compared with non-reactivation. Therefore, HBV-related HCC patients should undergo antiviral therapy and HBV-DNA monitoring before and during the combination treatment. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 13, 2024 Category: Microbiology Source Type: research

Editorial: The oral-gut axis: from ectopic colonization to within-host evolution of oral bacteria
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 13, 2024 Category: Microbiology Source Type: research

Genetic characterization of chicken infectious anaemia viruses isolated in Korea and their pathogenicity in chicks
Chicken infectious anaemia virus (CIAV) causes severe anemia and immunosuppression through horizontal or vertical transmission in young chickens. Especially, vertical transmission of virus through the egg can lead to significantly economic losses due to the increased mortality in the broiler industry. Here, 28 CIAV complete sequences circulating in Korea were first characterized using the newly designed primers. Phylogenetic analysis based on the complete sequences revealed that CIAV isolates were divided into four groups, IIa (2/28, 7.1%), IIb (9/28, 32.1%), IIIa (8/28, 28.6%) and IIIb (9/28, 32.1%), and exhibited a close...
Source: Frontiers in cellular and infection microbiology - February 13, 2024 Category: Microbiology Source Type: research

Cytokine expression in subjects with Mycobacterium avium ssp. paratuberculosis positive blood cultures and a meta-analysis of cytokine expression in Crohn ’s disease
ConclusionMost subjects in our sample had MAP infection and 8 of 9 subjects remained MAP positive one year later indicating persistent infection. While not identical, cytokine expression patterns in MAP culture positive CD patients in the TU/ACU study showed similarities (increased IL-17, IFNγ and TNFα) to patterns of patients with Tuberculosis in other studies, indicating the possibilities of similar mechanisms of pathogen infection and potential strategies for treatment. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 13, 2024 Category: Microbiology Source Type: research

Transcriptome and proteomic analysis of mpox virus F3L-expressing cells
ConclusionsOur analysis of transcriptomic and proteomic data showed that (1) F3L up-regulates the transcript levels of key genes in the innate immune signaling pathway, such as RIGI, MDA5, IRF5, IRF7, IRF9, ISG15, IFNA14, and elicits a broad spectrum of antiviral immune responses in the host. F3L also increases the expression of the FOS and JNK genes while decreasing the expression of TNFR2, these factors may ultimately induce apoptosis. (2) F3 protein interacts with host proteins involved in RNA splicing and protein translation, such as SNRNP70, POLR2H, HNRNPA1, DDX17, etc. The findings of this study shed light on the fun...
Source: Frontiers in cellular and infection microbiology - February 13, 2024 Category: Microbiology Source Type: research

Editorial: Foodborne bacterial pathogens under the One Health perspective - antimicrobial resistance, epidemiology, virulence, and zoonotic impact
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 12, 2024 Category: Microbiology Source Type: research

Assistance of next-generation sequencing for diagnosis of disseminated Bacillus Calmette-Guerin disease with X-SCID in an infant: a case report and literature review
This article presents a case of a 3-month-old patient with disseminated BCG infection who was initially diagnosed with hemophagocytic syndrome (HPS) and eventually found to have X-linked severe combined immunodeficiency (X-SCID). M.bovis and its drug resistance genes were identified by metagenomics next-generation sequencing (mNGS) combined with targeted next-generation sequencing (tNGS) in blood and cerebrospinal fluid. Whole exome sequencing (WES) revealed a pathogenic variant in the common γ-chain gene (IL2RG), confirming X-SCID. Finally, antituberculosis therapy and umbilical cord blood transplantation were given to t...
Source: Frontiers in cellular and infection microbiology - February 12, 2024 Category: Microbiology Source Type: research

Grasping knowledge, attitude, and perception towards monkeypox among healthcare workers and medical students: an Egyptian cross-sectional study
ConclusionKnowledge, attitude, and perception towards Mpox among Egyptian HCWs and medical students exhibit suboptimal levels. Addressing these gaps is crucial to controlling and effectively preventing disease transmission. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 12, 2024 Category: Microbiology Source Type: research

Exploring adjunctive therapies for cerebral malaria
Cerebral malaria (CM) is one of the most severe complications of malaria infection characterized by coma and neurological effects. Despite standardized treatment of malaria infection with artemisinin-based combination therapies (ACT), the mortality rate is still high, and it primarily affects pediatric patients. ACT reduces parasitemia but fails to adequately target the pathogenic mechanisms underlying CM, including blood-brain-barrier (BBB) disruption, endothelial activation/dysfunction, and hyperinflammation. The need for adjunctive therapies to specifically treat this form of severe malaria is critical as hundreds of th...
Source: Frontiers in cellular and infection microbiology - February 12, 2024 Category: Microbiology Source Type: research

Bibliometric analysis of antimalarial drug resistance
ConclusionThis study is the first visual metrological analysis of antimalarial drug resistance, using bibliometric methods. As a baseline information, it is important to analyze research output published globally on antimalarial drug resistance. In order to better understand the current research situation and future research plan agenda, such baseline data are needed accordingly. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 12, 2024 Category: Microbiology Source Type: research

Editorial: The ever so elusive pathogen-harboring biofilms on abiotic surfaces in the food and clinical sectors: the good, the bad and the slimy
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 9, 2024 Category: Microbiology Source Type: research

Metabolites of intestinal fora can be used as diagnostic and progressive markers for mild cognitive impairment
ConclusionSpecific metabolites of intestinal fora can be used as diagnostic and progressive markers for MCI. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 9, 2024 Category: Microbiology Source Type: research