Frontiers in cellular and infection microbiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gut microbiota and metabolite variations in a migraine mouse model
This study aimed to investigate the disparities in gut microbiota and metabolites between migraine mice model and normal mice to shed light on the underlying mechanisms and potential therapeutic approaches. Distinct differences in gut microbial composition were observed between the migraine mouse model and normal mouse, indicating a potential correlation between these variations and the pathogenesis of migraine. This study provides evidence of differences in gut microbiota composition and metabolites between a migraine mouse model and normal mice, which showed that Akkermansiaceae constituted the most abundant taxon in the...
Source: Frontiers in cellular and infection microbiology - January 31, 2024 Category: Microbiology Source Type: research

Fecal bacteria-free filtrate transplantation is proved as an effective way for the recovery of radiation-induced individuals in mice
ConclusionsFFT improves radiation-induced intestinal microecological dysbiosis by reshaping intestinal mucosal barrier function, gut microbiota configurations, and host metabolic profiles, highlighting FFT regimen as a promising safe alternative therapy for FMT is effective in the treatment of radiation intestinal injury. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 31, 2024 Category: Microbiology Source Type: research

Gram-negative bacterial sRNAs encapsulated in OMVs: an emerging class of therapeutic targets in diseases
Small regulatory RNAs (sRNAs) encapsulated in outer membrane vesicles (OMVs) are critical post-transcriptional regulators of gene expression in prokaryotic and eukaryotic organisms. OMVs are small spherical structures released by Gram-negative bacteria that serve as important vehicles for intercellular communication and can also play an important role in bacterial virulence and host-pathogen interactions. These molecules can interact with mRNAs or proteins and affect various cellular functions and physiological processes in the producing bacteria. This review aims to provide insight into the current understanding of sRNA l...
Source: Frontiers in cellular and infection microbiology - January 31, 2024 Category: Microbiology Source Type: research

Oral administration of lysozyme protects against injury of ileum via modulating gut microbiota dysbiosis after severe traumatic brain injury
ConclusionThe present study unveiled a virtuous cycle whereby oral administration of lysozyme restores Paneth cell’s function, mitigates intestinal injury and bacterial translocation through the remodeling of gut microbiota. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

Role of myeloid-derived suppressor cells in chronic brucellosis
ConclusionOur study described an increase of immunosuppressive MDSCs in peripheral blood of chronic brucellosis patients. These results contribute to the understanding of Brucella persistent infection, which may provide an insight for effective treatment of chronic brucellosis patients in clinical practice. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation
Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP is intervertebral disc degeneration (IDD), often triggered by intervertebral disc (IVD) inflammation. Inflammation of the IVD is divided into Septic and Aseptic inflammation. Conservative therapy and surgical treatment often fail to address the root cause of IDD. Recent advances in the treatment of IVD infection and inflammation range from antibiotics and small-molecule drugs to cellular therapies, biological agents, and innovative biomaterials. This review sheds light on the complex mechanism...
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection
Chronic pulmonary bacterial infections and associated inflammation remain a cause of morbidity and mortality in people with cystic fibrosis (PwCF) despite new modulator therapies. Therapies targeting host factors that dampen detrimental inflammation without suppressing immune responses critical for controlling infections remain limited, while the development of lung infections caused by antimicrobial resistant bacteria is an increasing global problem, and a significant challenge in CF. Pharmacological compounds targeting the mammalian MAPK proteins MEK1 and MEK2, referred to as MEK1/2 inhibitor compounds, have potential co...
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

Nanopore sequencing of infectious fluid is a promising supplement for gold-standard culture in real-world clinical scenario
In this study, we collected 297 suspected infectious fluids from 10 clinical centers and detected them with conventional microbiology culture and nanopore platform–based mNGS. The objective was to assess detective and diagnostic performance of nanopore-sequencing technology (NST) in real-world scenarios.ResultsCombined with gold-standard culture and clinical adjudication, nanopore sequencing demonstrated nearly 100% positive predictive agreements in microbial-colonized sites, such as the respiratory and urinary tracts. For samples collected from initially sterile body sites, the detected microorganisms were highly suspec...
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

First detection of Toxoplasma gondii Africa 4 lineage in a population of carnivores from South Africa
DiscussionThis is the first genetic characterization of T. gondii isolated from a wild carnivore on the African continent and the first report of T. gondii in Black-backed Jackal. The Africa 4 lineage was also confirmed in the region of Southern Africa for the first time. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

Questionnaire survey of risk factors for recurrence of ocular inflammation in patients with uveitis after SARS-CoV-2 infection
ConclusionThe degree of ocular inflammatory activity within 3 months prior to SARS-CoV-2 infection may be a major factor influencing the recurrence or exacerbation of uveitis after infection. Interruption of medication should be minimized in patients with unstable inflammatory control. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 30, 2024 Category: Microbiology Source Type: research

Prevalence of virulence- and antibiotic resistance-associated genotypes and phenotypes in Staphylococcus aureus strains from the food sector compared to clinical and cow mastitis isolates
ConclusionsOur results indicate that production of virulence factors, antibiotic resistance and biofilm formation can be found in S. aureus isolates from diverse environments, including the food industry, although some of these traits are more prevalent in strains isolated from infections in cows or humans. This emphasizes on the importance of monitoring the spread of these determinants not only in samples from the clinical environment, but also along the food chain, a strategy that falls under the prism of a one-health approach. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 29, 2024 Category: Microbiology Source Type: research

Editorial: Synergistic combinatorial treatments to overcome antibiotic resistance
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 26, 2024 Category: Microbiology Source Type: research

Exploring the relationship of supernumerary recurrent renal calculi formation and tick-borne infections: a case report
A 51-year-old male with a history of Cacchi-Ricci disease and long-standing infection with various species of Borrelia, Babesia, and Bartonella presented with recurrent symptoms of right-sided flank pain. Numerous renal calculi were identified on imaging. The etiology of the calculi had not been previously elucidated. Symptoms intermittently date back to 2002 when uric acid stones were identified. Subsequent calculi analysis revealed calcium oxalate stones. Despite the commonality of nephrolithiasis in patients with Cacchi-Ricci disease, the extreme number of calculi and recurrent presentation of symptoms persisted despite...
Source: Frontiers in cellular and infection microbiology - January 26, 2024 Category: Microbiology Source Type: research

Incongruence between confirmed and suspected clinical cases of Japanese encephalitis virus infection
ConclusionThe results of this study indicate that there is a certain discrepancy between clinically diagnosed and laboratory-confirmed cases of JE. Each reported case should be based on laboratory detection results, which is of great importance in improving the accuracy of case diagnosis and reducing misreporting. Our results are not only important for addressing JE endemic to the Sichuan province, but also provide a valuable reference for the laboratory detection of various notifiable infectious diseases in China and other regions outside China. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 26, 2024 Category: Microbiology Source Type: research

The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence
In this study, two distinct in vitro infection models of Aspergillus fumigatus, using murine macrophages (RAW264.7) and human lung epithelial cells (A549), were employed to identify the genes important for fungal adaptation during infection. Transcriptomic analyses of co-incubated A. fumigatus uncovered 140 fungal genes up-regulated in common between both models that, when compared with a previously published in vivo transcriptomic study, allowed the identification of 13 genes consistently up-regulated in all three infection conditions. Among them, the maiA gene, responsible for a critical step in the L-phenylalanine degra...
Source: Frontiers in cellular and infection microbiology - January 26, 2024 Category: Microbiology Source Type: research