Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice

Conclusion In this study, we found that a non-toxic dose of auranofin significantly aggravated the severity of the radiation-induced intestinal injury. This suggests that auranofin treatment can be an independent factor that influences the risk of intestinal complications after pelvic or abdominal radiotherapy. Ethics Statement All the protocols used in this study were approved by the Institutional Animal Care and Use Committee of the Korean Institute of Radiological and Medical Sciences (IACUC permit number: KIRAMS217-0007). Author Contributions H-JL, JS, and Y-BL designed the experiments. EL and JK conducted the experiments and performed the data analysis. HL and J-YR contributed in manuscrpript revision. All authors discussed the results and contributed to manuscript writing. Funding This study was supported by grants from the Korea Institute of Radiological and Medical Sciences, funded by Ministry of Science and ICT (MSIT), South Korea (No. 50531-2018) and the Nuclear Research and Development Program of the National Research Foundation of Korea (NRF), funded by MSIT, South Korea (No. 50031-2018). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Abbreviations NAC, N-acetyl-L-cysteine; siRNA, small interfering RNA; TrxR, thioredoxin reductase; TUDCA, tauroursodeoxycholic acid; TUNEL, terminal deoxynucleotidyl t...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research