Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit Hongye Zhao1,2, Tiezheng Zheng1, Xiaohan Yang1, Ming Fan3, Lingling Zhu3, Shuhong Liu3, Liying Wu3 and Changkai Sun1,4* 1Department of Physiology and Key Laboratory of Brain Diseases of Liaoning Province, School of Basic Medical Sciences, Dalian Medical University, Dalian, China 2Department of Physiology, School of Basic Medical Sciences, Qiqihar Medical University, Qiqihar, China 3Department of Brain Protection and Plasticity, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, China 4Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering &Research Center for the Control Engineering of Translational Precision Medicine, Dalian University of Technology, Dalian, China Cryptotanshinone (CTs), an active component isolated from the root of Salvia miltiorrhiza (SM), has been shown to exert potent neuroprotective property. We here established an oxygen-glucose deprivation/recovery (OGD/R)-injured Neurovascular Unit (NVU) model in vitro to observe the neuroprotective effects of CTs on cerebral ischemia/reperfusion injury (CIRI), and explore the underlying mechanisms. CTs was observed to significantly inhibit the OGD/R-induced neuronal apoptosis, and decease the activation of Caspase-3 and the degradation of poly-ADP-ribose polymerase (PARP), as well as the increase of Bax/...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Authors: Pennisi PA, Fernández MC, Martin A Abstract Pheochromocytomas/paragangliomas (PCCs/PGLs) are rare neuroendocrine tumors, developed from chromaffin cells derived from the neural crest. From a genetic point of view PCCs/PGLs are divided as sporadic cases, and inherited cases as part of hereditary (familial) syndromes. While the majority is benign, up to 26% of PCCs/PGLs will undergo malignant transformation. Validated prognostic pathological parameters for malignant PCCs/PGLs are still lacking. Signaling that follows the interactions between IGFs and their receptor/s in tumor cells received extensive ...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Silva MAFS, Dechichi P, Limirio PHJO Abstract Childhood obesity is a considerable worldwide health problem and a major risk factor for several chronic diseases. Fat rich diets result in altered serum levels of lipids, cytokines and hormonal factors, which influence skeletal acquisition and promote microstructural and mechanical behavior changes in bone, especially to bone quality and quantity. However, the possible longterm implications of high-fat diets in childhood are controversial. Despite not fully understood, multiple signaling pathways which support bone tissue homeostasis are altered under hyperlip...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
The first European Academy of Dermatology and Venereology (EADV) congress was held in 1989 in Florence, Italy. Since then, the EADV has grown to a large organization with 7,100 members from 110 countries. Although the focus of the EADV is mainly on patient care and physician education, its mission is also to advance research in dermatology and venereology. Although the European Society for Dermatological Research (ESDR) is older than the EADV, it is smaller with approximately 1,100 active members.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: ESDR – A Gateway for Global Interactions Source Type: research
The turmoil and devastating destruction of World War II had also ruined dermatology across Europe. In contrast, the Society of Investigative Dermatology (SID; founded in 1937) in the United States functioned successfully and soon became a role model for the leaders of dermatology departments in  various European countries. Our former teachers in dermatology succeeded in overcoming the prejudice and animosity in the western world. This outcome was the conception of the founding fathers (there was no founding lady in the initial group) of the European Society for Dermatological Research (ES DR).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
On behalf of all the Japanese Society for Investigative Dermatology (JSID) members, we would like to congratulate the European Society for Dermatological Research (ESDR) on its 50th anniversary! It must have been a long and winding road to achieve the current big success of ESDR, which always provides a harmonious and welcoming atmosphere to people attending its meetings from around the world. Although each country in European communities has a different background, ESDR unites people with the same aim to advance investigative dermatology and cutaneous biology.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: ESDR – A Gateway for Global Interactions Source Type: research
When I started my clinical training in dermatology in 1981 and got involved in basic research in 1984, in those days for young German-speaking dermatology researchers, there was one important scientific meeting, the meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF, Association of Dermatological Research). Presenting an abstract at this meeting was a must, and having been selected for oral presentation was an extraordinary achievement. There was another extremely important forum, the meeting of the Society of Investigative Dermatology (SID).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
Authors: Antinozzi C, Sgrò P, Di Luigi L Abstract Among metabolic diseases, carbohydrate metabolism disorders are the most widespread. The most common glucose pathological conditions are acquired and may increase the risk of type 2 diabetes, obesity, heart diseases, stroke, and kidney insufficiency. Phosphodiesterase type 5 inhibitors (PDE5i) have long been used as an effective therapeutic option for the treatment of erectile dysfunction (ED). Different studies have demonstrated that PDE5i, by sensitizing insulin target tissues to insulin, play an important role in controlling the action of insulin and gluco...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Authors: Vibhatavata P, Pisarnturakit P, Boonsripitayanon M, Pithuksurachai P, Plengvidhya N, Sirinvaravong S Abstract Postoperative hypoparathyroidism is a common complication of total or completion thyroidectomy. The association between preoperative vitamin D deficiency (VDD) and the development of more severe postoperative hypocalcemia is still unclear. Objectives. To evaluate the effect of preoperative VDD on severity of hypocalcemia in patients with hypoparathyroidism following thyroidectomy. Methods. Patients who developed acute hypoparathyroidism after total or completion thyroidectomy, defined as postoperat...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Authors: Hu B, Zhao M, Luo D, Yu C, Shao S, Zhao L, Yang Y, Zhang X, Zhao J, Gao L Abstract Hypothyroidism is a common disease, and its molecular mechanism still needs further investigation. Lysine succinylation is found to be involved in various metabolic processes associated with hypothyroidism. We performed quantitative analysis on lysine succinylome in thyroids of rats with hypothyroxinemia, which was induced through the administration of a high-fat diet. Overall, 129 differentially expressed proteins were quantified. Downregulated proteins were enriched in the thyroid hormone synthesis and thyroid hormone sign...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Conclusion: Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy. PMID: 32774360 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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