Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit

Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China's Guidelines for Care and Use of Laboratory Animals, Medical Ethics Committee of Dalian Medical University. The protocol was approved by the Medical Ethics Committee of Dalian Medical University. Author Contributions CS, LZ, and MF were involved in designing the study, interpreting the data and writing the manuscript. HZ, TZ, and XY performed the majority of the experiments. SL and LW contributed to the analysis of the data. Funding This work was supported by funding from the National Science and Technology Major Special Project on Major New Drug Innovation of China (No. 2012ZX09503-001-003). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research