Targeted Delivery of Chlorin e6 via Redox Sensitive Diselenide-Containing Micelles for Improved Photodynamic Therapy in Cluster of Differentiation 44-Overexpressing Breast Cancer

Conclusions In this study, we developed a minimalist photosensitizer delivery system. HA-sese-Ce6 micelles showed targeted, redox sensitive delivery of Ce6 to 4T1 breast cancer cells. The therapeutic effect of this method could be maximized via positive feedback because the activated Ce6 generates singlet oxygen molecules, which helps to break more diselenide bonds on the micelles. These characteristics were confirmed in 4T1 mice breast cancer cells and in vivo 4T1 tumor bearing mice models. This unique HA-sese-Ce6 micelles exhibited a great anti-cancer effect and metastasis inhibition. We believe that this can be a promising new strategy for improved photosensitizer delivery in breast cancer treatment. Ethics Statement This study was carried out in accordance with the recommendations of ‘Tongji University Animal Ethics guidelines, name of committee’. The protocol was approved by Tongji University Animal Ethics Committee. Author Contributions CF, CD, and YM designed the experiments. CF, DZ, LC, LL, and JL carried out the experiments. NK, SL, XZ, and YL helped to analyze the experimental results. CF wrote the manuscript. Funding This work was supported by National Natural Science Foundation of China Regional Project (81860547), National Natural Science Foundation of China Project (81573008), Key Cross-cutting Projects of Central Universities (150721907), Pilot Talent Training Program of Shanghai East Hospital (No. 201701), Research project of Sha...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research