Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid

Conclusion:
We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876

Received: 27 July 2016
Revised: 30 December 2016
Accepted: 19 January 2017
Published: 05 July 2017
Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Telephone: [phone]; Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP876).
The authors declare that they have no actual or potential competing financial interests.
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Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research