Nasal screening for methicillin-resistant Staphylococcus aureus does not reduce surgical site infection after primary lumbar fusion
Background Context: Preoperative methicillin-resistant Staphylococcus aureus (MRSA) testing and decolonization has demonstrated success for arthroplasty patients in surgical site infections (SSIs) prevention. Spine surgery, however, has seen varied results. Purpose: The purpose of this study was to determine the impact of nasal MRSA testing and operative debridement rates on surgical site infection after primary lumbar fusion. Study Design/setting: Retrospective cohort study and/or Consolidated medical enterprise PATIENT SAMPLE: Adult patients undergoing primary instrumented lumbar fusions from January 2015 to December 2...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news

Efficacy of antimicrobial peptide LL-37 against biofilm forming Staphylococcus aureus strains obtained from chronic wound infections
The antimicrobial peptide LL-37 showed inhibitory effects against Staphylococcus aureus strains, which often responsible for wound infections. Understanding the molecular mechanisms of biofilm-containing wound infections is important. Thus, this study aimed to investigate both the antimicrobial and biofilm efficacy of LL-37 against biofilm-positive methicillin-susceptible S. aureus (MSSA) strains and biofilm-positive methicillin-resistant S. aureus (MRSA) strains obtained from chronic wound infections and its effect on different quorum sensing and virulence genes at suboptimal concentrations. Fifteen biofilm-forming MRSA a...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news

Combined sterilization and fabrication of drug-loaded scaffolds using supercritical CO 2 technology
The access of biodegradable scaffolds to the clinical arena is constrained by the absence of a suitable sterilization technique for the processing of advanced polymeric materials. Sterilization with supercritical CO 2 (scCO 2 ) may circumvent some technological limitations (e.g., low temperature, no chemical residues on the material), although scCO 2 can plasticize the polymer depending on the processing conditions used. In this latter case, the integration of the manufacturing and sterilization processes is of particular interest to obtain sterile and customized scaffolds in a single step. In this work, scCO 2 was exploit...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news

Antimicrobial effectiveness of wound matrices containing native extracellular matrix with polyhexamethylene biguanide
This study compares the antimicrobial and wound healing capabilities, both in vivo and in vitro against methicillin-resistant Staphylococcus aureus (MRSA) USA 300, for the following compounds: Collagen Wound Matrix-Anti Microbial (CWM-AM); Collagen Wound Matrix-Anti Microbial XT (CWM-AM XT); Antimicrobial Hydrofiber Wound Dressing (AHWD); Dermal Scaffold with Silver (DRSAg); Collagen Extracellular Matrix (CEM); Collagen Wound Matrix (CWM); Matrix Wound Dressing with Silver (MWDAg); Cadexomer Iodine Gel (CIG); Triple Antibiotic Ointment (TAO); and Antimicrobial Wound Gel (AWG). For the in vitro zone of inhibition assay, AWG...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news

Antibiotic Resistant Bacterium MRSA Evolved In Hedgehogs 200 Years Ago, Study Finds
One type of methicillin-resistant Staphylococcus aureus – MRSA, the antibiotic-resistant bacterial scourge of modern clinical medicine – may have evolved 200 years ago in wild European hedgehogs, according to a recent study. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - January 7, 2022 Category: Pharmaceuticals Authors: Kiona N. Smith, Contributor Tags: Science /science Innovation /innovation Healthcare /healthcare Editors' Pick editors-pick Source Type: news

Hedgehogs Are a Source of Drug-Resistant Bacteria, Study Finds
Scientists chart how a battle between fungus and bacteria living on the skin of hedgehogs led to the emergence of a strain of MRSA that can infect cows and humans. (Source: NYT Health)
Source: NYT Health - January 5, 2022 Category: Consumer Health News Authors: Andrew Jacobs Tags: Hedgehogs Methicillin-Resistant Staphylococcus Aureus Drug Resistance (Microbial) Antibiotics Bacteria Research Nature (Journal) your-feed-science your-feed-animals Source Type: news

Effectiveness and real-world materials compatibility of a novel hydrogen peroxide disinfectant cleaner.
A novel 4% hydrogen peroxide disinfectant was effective against methicillin-resistant Staphylococcus aureus (MRSA), Clostridioides difficile spores, carbapenem-resistant Escherichia coli, and 2 strains of Candida auris. In laboratory testing, a sodium hypochlorite disinfectant caused fading and loss of pliability of a hospital mattress, but the hydrogen peroxide disinfectant did not. These findings suggest that the hydrogen peroxide-based disinfectant may be a useful addition to the sporicidal disinfectant products available for use in healthcare settings. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news

Hospital- and System-Wide Interventions for Health Care-Associated Infections: A Systematic Review.
Hospitals face increasing pressure to reduce health care-associated infections (HAI) due to their costs and evidence of preventability. However, there is limited synthesis of evidence regarding interventions that can be successfully implemented hospital- or system-wide. Using Donabedian's structure-process-outcome model, we conducted a systematic literature review from 2008 to early 2019, identifying 96 studies with 214 outcomes examining the relationship between hospital- or system-wide interventions and HAIs. This literature's methodologic and reporting quality was generally poor. The most common HAIs studied were methic...
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news

Environmental Shedding of MRSA Is Far Greater than from Multidrug-Resistant Gram-Negative Bacilli
An observational cohort study revealed shedding of methicillin-resistant Staphylococcus aureus by colonized patients outside hospital rooms or during outpatient clinic visits occurred more often than in those colonized by multidrug-resistant gram-negative bacilli. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news

Risk factors for nosocomial methicillin resistant Staphylococcus aureus (MRSA) colonization in a neonatal intensive care unit: A Case-control study
Persistently circulating MRSA clone in NICU. • Risk factors for MRSA colonization, independent of length of stay& gestational age. • Colonization pressure, lower ATP pass rate are associated with acquisition of colonization. • Higher acuity of care is also associated with acquisition of colonization. • In a multivariable model, only colonization pressure was significantly associated. To determine risk factors for MRSA col onization in a Level IV Neonatal Intensive Care Unit (NICU) independent of length of stay and gestational age in the context of a persistently circulating MRSA clone. Retrospective...
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news

Does high adherence to contact precautions lead to low in-hospital transmission of multidrug-resistant microorganisms in the endemic setting? "
Conclusion: High adherence coupled with continuous monitoring of CP correlated to a very low in-hospital transmission rate. These results indicate that CP is highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news

Investigations of Staphylococcal contamination on environmental surfaces of a neonatal intensive care unit of a children's hospital
Viable Staphylococci were found on 54% of NICU surfaces sampled. • Mannitol-negative Staphylococci were dominant type of Staphylococci found. • MRSA was the lowest percentage of Staphylococci, found on 11% of sites. • Greatest NICU presence of Staphylococci found on floors and return air ducts. • Contamination of floors and return air ducts could serve as a pathogen reservoir. Staphylococci species are known to cause healthcare-associated infections in neonatal intensive care (NICU) unit patients. Little is known about Staphylococcal contamination of NICU environments. Swabs from 25 of 46 (54%) surfaces...
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news

Former Naturopath Convicted of Trafficking in Misbranded Drugs He Claimed Could Treat and Prevent COVID
FDA OCI, Richard Marschall, Port Angeles WA, convict, misbranded, treat, prevent, COVID-19, MRSA, "Dynamic Duo", garlic extract, larch tree starch, Dr. Rick Marschall, revoked license, naturopath, coronavirus, consumer protection, health care fraud, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 29, 2021 Category: Medical Law Authors: DOJ Source Type: news

Does high adherence to contact precautions lead to low in-hospital transmission of multi-drug-resistant micro-organisms in the endemic setting?
Conclusion: High adherence coupled with continuous monitoring of CPs correlated with a very low in-hospital transmission rate. These results indicate that CPs are highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 15, 2021 Category: Consumer Health News Source Type: news

Surveillance for Healthcare-Associated Infections: Hospital-Onset Adult Sepsis Events Versus Current Reportable Conditions
Conclusions CDC's HO-ASE definition detects many serious nosocomial infections missed by currently reportable HAIs. HO-ASE surveillance could increase the efficiency and clinical significance of surveillance while identifying new targets for prevention. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 8, 2021 Category: Consumer Health News Source Type: news

Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK
These evidence-based guidelines are an updated version of those issued in 2008. They have been produced following a review of the published literature (2007 –18) pertaining to the treatment of infections caused by MRSA. The guidelines update, where appropriate, previous recommendations, taking into account changes in the UK epidemiology of MRSA, ongoing national surveillance data and the efficacy of novel anti-staphylococcal agents licensed for use in the UK. Emerging therapies that have not been licensed for use in the UK at the time of the review have also been assessed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 10, 2021 Category: Consumer Health News Source Type: news

Infectious Disease Alert Updates
Sepsis Bundle Erodes Gains in Stewardship; Asymptomatic Transmission of COVID-19 in Households; When Is Hand Hygiene Personally Protective? Four different categories of antibiotic use were observed, including broad-spectrum antibiotics for community-acquired infection, broad-spectrum antibiotics for nosocomial infection/multidrug-resistant organisms, the use of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents (such as vancomycin, daptomycin, linezolid, ceftaroline, etc.), as well as antibiotics for surgical prophylaxis. [...]a gap of up to 24 hours may occur before the physician picking up the case the next d...
Source: Current Awareness Service for Health (CASH) - August 12, 2021 Category: Consumer Health News Source Type: news

Shedding of methicillin-resistant Staphylococcus aureus and multidrug-resistant gram-negative bacilli during outpatient appointments and procedures outside hospital rooms
We examined shedding during appointments outside patient rooms. • 38.5% of MRSA-colonized patients shed MRSA during appointments. • Presence of wounds with MRSA was a significant risk for environmental shedding. • No shedding of multidrug-resistant gram-negative bacilli was detected. Limit ed information is available on the frequency of and risk factors for shedding of health care-associated pathogens in settings outside patient rooms. We conducted a cohort study of hospitalized or recently discharged patients with methicillin-resistant Staphylococcus aureus (MRSA) (N = 39) or multidr ug-resistant gram-negat...
Source: Current Awareness Service for Health (CASH) - August 12, 2021 Category: Consumer Health News Source Type: news

MoWa: A Disinfectant for Hospital Surfaces Contaminated With Methicillin-Resistant Staphylococcus aureus (MRSA) and Other Nosocomial Pathogens
Conclusions: MoWa kills planktonic and biofilms made by MRSA and MSSA strains and showed great efficacy to disinfect MRSA-, and MSSA-contaminated, surfaces and surfaces contaminated with other important nosocomial pathogens. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 12, 2021 Category: Consumer Health News Source Type: news

Combining pulsed xenon ultraviolet disinfection with terminal manual cleaning helps reduce the acquisition rate of methicillin-resistant Staphylococcus aureus
This study aimed to investigate the effect of adding pulsed xenon UV (PX-UV) disinfection to the terminal cleaning protocol on the rate of methicillin-resistant Staphylococcus aureus (MRSA) acquisition at a Japanese hospital. The use of a PX-UV disinfec tion device was added to the manual terminal cleaning protocol applied after the discharge or transfer of patients treated in the intensive and high care units. We used a Poisson regression model to examine the incidence of MRSA acquisition, based on the study period, PX-UV intervention status, unit type, and the rate of consumption of alcohol-based hand rub (ABHR). Approxi...
Source: Current Awareness Service for Health (CASH) - August 12, 2021 Category: Consumer Health News Source Type: news

AHRQ: Agency Information Collection Activities: Proposed Collection; Comment Request
Notice from the Agency for Healthcare Research and Quality (AHRQ) extending the comment period on the proposed information collection titled "The AHRQ Safety Program for Methicillin-Resistant Staphylococcus aureus (MRSA) Prevention." This project will assist hospital units and long-term care facilities in adopting and implementing technical approaches to reduce MRSA infections. Comments are due by August 23, 2021. (Source: Federal Register updates via the Rural Assistance Center)
Source: Federal Register updates via the Rural Assistance Center - July 22, 2021 Category: Rural Health Source Type: news

Knowledge of infection prevention and control among healthcare workers and factors influencing compliance: a systematic review
Conclusion: Embracing a multifaceted approach towards improving IPC-intervention strategies is highly suggested. The goal being to improve compliance among HCWs with IPC measures is necessary. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 16, 2021 Category: Consumer Health News Source Type: news

Emerging resistance mechanisms for 4 types of common anti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review
Staphylococcus aureus is one of the leading hospital-associated and community-associated pathogens, which has caused a global public health concern. The emergence of methicillin-resistant S. aureus (MRSA) along with the widespread use of different classes of antibiotics has become a significant therapeutic challenge. Antibiotic resistance is a disturbing problem that poses a threat to humans. Treatment options for S. aureus resistant to β-lactam antibiotics include glycopeptide antibiotic, cyclic lipopeptide antibiotic, cephalosporins and oxazolidinone antibiotic. The most representative types of these antibiotics are...
Source: Current Awareness Service for Health (CASH) - July 16, 2021 Category: Consumer Health News Source Type: news

Antibiotic Resistance Crisis: An Update on Antagonistic Interactions between Probiotics and Methicillin-Resistant Staphylococcus aureus (MRSA)
Antimicrobial resistance (AMR) havoc is a global multifaceted crisis endowing a significant challenge for the successful eradication of devastating pathogens. Methicillin-Resistant Staphylococcus aureus (MRSA) is an enduring superbug involved in causing devastating infections. Although MRSA is a frequent colonizer of human skin, wound, and anterior nares, the intestinal colonization of MRSA has greatly increased the risk of inducing MRSA-associated colitis besides creating a conducive environment for horizontal transfer of resistant genes to commensal microbes. On the other hand, staphylococcal resistance to last-resort an...
Source: Current Awareness Service for Health (CASH) - July 16, 2021 Category: Consumer Health News Source Type: news

Staphylococcus aureus Ventilator-Associated Pneumonia: A Study of Bacterio-Epidemiological Profile and Virulence Factors
Ventilator-associated pneumonia (VAP) represents a major cause of nosocomial infections in the intensive care units in which Staphylococcus aureus is frequently involved. Better knowledge of this pathogen is required in order to enhance the patient's treatment and care. In this article, we studied the bacteriological profile and virulence factors of S. aureus-related VAP on a 3-year period. We included a collection of S. aureus strains (n = 35) isolated from respiratory samples from patients diagnosed with VAP in the intensive care units. We studied the bacteriological aspects and we searched for the presence of virulence ...
Source: Current Awareness Service for Health (CASH) - July 16, 2021 Category: Consumer Health News Source Type: news

Nigeria: Why a Bacterium in Goat and Sheep Milk in Southwest Nigeria Poses a Health Risk
[The Conversation Africa] Sheep and goats in southwest Nigeria are carrying bacteria that are resistant to a range of drugs, such as antibiotics. This is a problem because the bacterium, methicillin-resistant Staphylococcus aureus, poses a potential health risk to the owners as well as to the general population. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - July 7, 2021 Category: African Health Source Type: news

Is methicillin-resistant Staphylococcus aureus a common pathogen in ventilation-associated pneumonia?: The experience of a tertiary teaching hospital in Jordan
Abstract: Ventilator-associated pneumonia is a life threatening device related infection in intensive care units. Methicillin-resistant Staphylococcus aureus is considered a common contagious pathogen causing pneumonia and sepsis. To assess the prevalence of S aureus in comparison to other pathogens, and their antibacterial sensitivity profile in ventilator-associated pneumonia. Data regarding ventilator-associated pneumonia of adults admitted to the intensive care unit, at the Jordan University of Science and Technology Hospital, between 2012 and 2018 were extracted from the computerized system. Microorganisms and their s...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Optimal trough concentration of teicoplanin for the treatment of methicillinresistant Staphylococcus aureus infection: A systematic review and metaanalysis
What is known and objective: It has been recommended that the trough concentration (Cmin) of teicoplanin should be maintained at ≥20 μg/ml for difficult‐to‐treat complicated infections caused by methicillin‐resistant Staphylococcus aureus (MRSA). Conversely, Cmin of teicoplanin of at least 10 μg/ml is required for non‐complicated MRSA infections. Considering the low incidence of nephrotoxicity for teicoplanin, Cmi n = 15–30 μg/ml has been suggested for most MRSA infections. Thus, we assessed the clinical efficacy and adverse effects of teicoplanin at this target Cmin. Methods: We searched electron...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Does the removal of contact precautions for MRSA and VRE infected patients change health care-associated infection rate?: A systematic review and meta-analysis
Update existing meta-analysis to analyze if discontinuation of contact precautions (CPs) for Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin resistant Enterococcus (VRE) colonization or infection affects hospital-associated MRSA or VRE infection rates. We conducted a systematic review of 17 studies evaluating discontinuation of CPs for MRSA and VRE. Random-effects and fixed-effects models were used to determine the pooled risk ratios (RR) of preincidence hospital-associated infection rate to postincidence rate. Subgroup analysis was used to assess sources of heterogeneity. No significant difference betwee...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Vancomycin Area Under the Curve-Guided Dosing and Monitoring for Adult and Pediatric Patients With Suspected or Documented Serious Methicillin-Resistant Staphylococcus aureus Infections: Putting the Safety of Our Patients First
The revised vancomycin consensus guidelines recommended area under the curve (AUC)-guided dosing/monitoring for patients with serious invasive methicillin-resistant Staphylococcus aureus (MRSA) infections as a measure to minimize vancomycin-associated acute kidney injury (VA-AKI) while maintaining similar effectiveness. Data indicate that the intensity of vancomycin exposure drives VA-AKI risk. Troughs of 15-20 mg/L will ensure an AUC ≥400 mg × hr/L but most patients will have daily AUCs>600. VA-AKI increases as a function of AUC, especially when>600. In addition to minimizing VA-AKI risk while maintaining s...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

MRSA Transmission in Intensive Care Units: Genomic Analysis of Patients, Their Environments, and Healthcare Workers
Background Methicillin-resistant Staphylococcus aureus (MRSA) —and now USA300 MRSA—is a significant intensive care unit (ICU) pathogen; healthcare worker (HCW) contamination may lead to patient cross-transmission. Methods From September 2015 to February 2016, to study the spread of MRSA, we enrolled HCWs in 4 adult ICUs caring for patients on MRSA contact precautions. Samples were collected from patient body sites and high-touch surfaces in patient rooms. HCW hands, gloves, and personal protective equipment were sampled pre/post-patient encounter. Whole genome sequencing (WGS) was used to compare isolates from ...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Effect of ablution on Methicillin-resistant Staphylococcus aureus (MRSA) nasal colonisation in healthcare workers
Healthcare workers (HCWs) with MRSA nasal colonisation pose a serious threat of passing on the infection to patients. A cross sectional study was designed to investigate the effect of ablution on MRSA nasal colonisation and was conducted at the Department of Pathology, King Edward Medical University. A total of 220 nasal swab samples, 110 from ablution performing HCWs and 110 from non-ablution performing HCWs were processed for the identification of Staphylococcus aureus and sensitivity testing for Cefoxitin. In the ablution performing group, 11(10%) HCW were harbouring Staphylococcus aureus in their nose, while in non-abl...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Evaluation of the timing of MRSA PCR nasal screening: How long can a negative assay be used to rule out MRSA-positive respiratory cultures? "
Conclusion We report high NPVs for up to 2 weeks between specimen collections, which allows clinicians to use a negative MRSA PCR nasal screen assay to rule out MRSA pneumonia, potentially leading to decreased exposure to MRSA-active antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

More research funding needed to avoid drug-resistant pandemic, warns report
Smaller firms are developing most antibiotics targeting superbugs but often at risk of bankruptcySmall drugmakers and biotech firms that are developing the bulk of new antibiotics need far more financial support, according to a new report, which warned that without these life-saving medicines there could be a pandemic of drug-resistant infections, worse than Covid-19.The Access to Medicine Foundation, an Amsterdam-based non-profit group, said small and medium-sized firms, which account for three-quarters of all late-stage antibiotics in development, struggle to secure enough funding and are often at risk of bankruptcy, pot...
Source: Guardian Unlimited Science - June 10, 2021 Category: Science Authors: Julia Kollewe Tags: Pharmaceuticals industry Infectious diseases Antibiotics MRSA and superbugs Drugs Medical research Microbiology Business Society Coronavirus Health Science Source Type: news

Susceptibility to chlorhexidine and mupirocin among methicillin-resistant Staphylococcus aureus clinical isolates from a teaching hospital, Revista do Instituto de Medicina Tropical de Sao Paulo
Despite the widespread use of chlorhexidine (CHX) to prevent infection, data regarding the in vitro action of CHX against methicillin-resistant Staphylococcus aureus (MRSA) are limited. Clinical isolates from Hospital das Clinicas, Sao Paulo, Brazil, identified during 2002/2003 and 2012/2013 were studied to describe the susceptibility to CHX and mupirocin, molecular characteristics, and virulence profile of MRSA. Susceptibility test to Mupirocin was performed by the disk diffusion method and to CHX by the agar dilution technique. PCR for virulence genes, mecA gene and Staphylococcal Cassette Chromosome mec (SCCmec) types w...
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news

Daptomycin Plus Fosfomycin Versus Daptomycin Alone for Methicillin-resistant Staphylococcus aureus Bacteremia and Endocarditis: A Randomized Clinical Trial, Clinical Infectious Diseases
Conclusions Daptomycin plus fosfomycin provided 12% higher rate of treatment success than daptomycin alone, but this difference did not reach statistical significance. This antibiotic combination preven ted microbiological failure and complicated bacteremia, but it was more often associated with adverse events. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news

Microneedle patch delivers antibiotics locally in the skin
(Karolinska Institutet) MRSA skin infections are often treated with intravenous injection of antibiotics, which can cause significant side effects and promote the development of resistant bacterial strains. To solve these problems, researchers at Karolinska Institutet in Sweden are developing a microneedle patch that delivers antibiotics directly into the affected skin area. New results published in Advanced Materials Technologies show that the microneedle patch effectively reduces MRSA bacteria in the skin. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 10, 2021 Category: Infectious Diseases Source Type: news

A Systematic Review on the Efficacy of Vaporized Hydrogen Peroxide as a Non-Contact Decontamination System for Pathogens Associated with the Dental Environment
Int. J. Environ. Res. Public Health2021,18(9), 4748;https://doi.org/10.3390/ijerph18094748Received: 27 January 2021 / Revised: 30 March 2021 / Accepted: 25 April 2021 / Published: 29 April 2021AbstractAerosol generation and a wide range of pathogens originating from the oral cavity of the patient contaminate various surfaces of the dental clinic. The aim was to determine the efficacy of vaporized hydrogen peroxide fogging on pathogens related to the dental environment and its possible application in dentistry. PICOS statement (Population, Intervention, Comparison/Control, Outcome and Study design statement) was used in the...
Source: Dental Technology Blog - May 5, 2021 Category: Dentistry Source Type: news

Matt Hancock warns modern medicine may cease to exist without if superbugs are not tackled
Drug-resistant diseases such as MRSA already kill 700,000 people around the world each year - including 800 in Britain. But experts fear this could surge to 10million by 2050 without action. (Source: the Mail online | Health)
Source: the Mail online | Health - April 29, 2021 Category: Consumer Health News Source Type: news

Unintended consequences of infection prevention and control measures during COVID-19 pandemic, American Journal of Infection Control
The impact of a multimodal infection control strategy originally designed for containment of COVID-19 on the rates of other hospital-acquired-infections (HAIs) was evaluated over a 7-month period across the largest healthcare system in Singapore. • During the COVID-19 pandemic, methicillin-resistant Staphylococcus aureus acquisition rates declined significantly, together with central-line-associated-bloodstream infection rates; likely due to increased compliance with standard precautions. • Enhanced infection control measures resulted in the unintended positive consequences of containing health care-associated re...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

MRSA Colonization Linked to Increased Mortality Risk in Adults
WEDNESDAY, April 14, 2021 -- Among middle-aged and older community-dwelling adults, methicillin-resistant Staphylococcus aureus (MRSA) colonization is associated with increased mortality risk, according to a research letter published in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 14, 2021 Category: Pharmaceuticals Source Type: news

Why the Healthcare Association of New York State is partnering with Vyv
Vyv makes non-ultraviolet LEDs that kill microbes — including bacteria such as MRSA, salmonella, E. coli and C. diff. — that grow on surfaces. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 13, 2021 Category: Biotechnology Authors: Justin Dawes Source Type: news

Healthcare-associated infections
Clostridioides difficile (C. difficile), methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) are bacterial infections that commonly occur as a direct result of healthcare interventions (such as medical or surgical treatment), or from being in contact with a healthcare setting. They are the most well-known healthcare-associated infections (HCAIs). HCAIs pose a serious risk to patients, staff and visitors, can incur high costs for the NHS, and can cause significant morbidity to those infected. The emergence of new infections also poses a risk to patients and staff, as highlighted by the transmis...
Source: Current Awareness Service for Health (CASH) - March 26, 2021 Category: Consumer Health News Source Type: news

Silent MRSA carriers have twice the mortality rate of adults without the bacteria
(University of Florida) More than 3 million people in the U.S. carry MRSA, the staph strain that is hard to treat and resistant to many antibiotics. Unless MRSA carriers develop an infection or are tested for the bacteria, they may not even know they carry it, yet they are at significant risk for premature death. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 26, 2021 Category: Infectious Diseases Source Type: news

A sense for the unseen: Novel DNA sensor can rapidly detect antibiotic-resistant pathogens
(University of Fukui) The persistent overuse of antibiotics has led to the evolution of antibiotic resistant pathogens, or " superbugs, " which can cause severe life-threatening infections that must be diagnosed and treated early on. However, antibiotic sensitivity assays used to detect resistance rely on cell culture that can take several days. Overcoming this limitation, researchers have now designed a novel self-driven DNA nanosensor that can rapidly detect methicillin-resistant Staphylococcus aureus, a lethal superbug, with high sensitivity and specificity. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 22, 2021 Category: Infectious Diseases Source Type: news

New antibiotic clears multi-drug resistant gonorrhea in mice in single dose
(Penn State) A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University. The compound targets a molecular pathway found in bacteria but not humans and could lead to new treatments for gonorrhea and infections from other bacteria, such as tuberculosis and MRSA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2021 Category: International Medicine & Public Health Source Type: news

Estimated Methicillin-Resistant Staphylococcus aureus Decolonization in Intensive Care Units Associated With Single-Application Chlorhexidine Gluconate or Mupirocin, JAMA Network Open 4(3): e210652-e210652
Conclusions and Relevance: These findings suggest that there may be room for significant improvement in anti-MRSA disinfectants, including the compounds themselves and their delivery mechanisms. Despite the decolonization estimates found in this study, these agents are associated with robust outcomes after delays in administration, which may help in alleviating concerns over patient comfort and toxic effects. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

MRSA prevalence and hospital-level antibiotic use: A retrospective study across 122 acute-care hospitals, Infection Control & Hospital Epidemiology 42(3): 353-355
We evaluated the relationship between local MRSA prevalence rates and antibiotic use across 122 VHA hospitals in 2016. Higher hospital-level MRSA prevalence was associated with significantly higher rates of antibiotic use, even after adjusting for case mix and stewardship strategies. Benchmarking anti-MRSA antibiotic use may need to adjust for MRSA prevalence. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Effect of vancomycin loading dose on clinical outcome in critically ill patients with methicillin-resistant Staphylococcus aureus pneumonia, Journal of Thoracic Disease 13(2): 768-777
Background: Vancomycin is the treatment of choice for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Current guidelines recommend giving an initial loading dose (LD) of 25-30 mg/kg to rapidly increase the serum concentration. However, high-quality evidence for the clinical benefit of LD is lacking. Herein, we aim to examine the association between vancomycin LD and clinical outcome. Methods: A retrospective cohort study was conducted on adult patients treated for MRSA pneumonia with vancomycin in medical intensive care units from April 2016 to August 2018. MRSA pneumonia was defined by the Centers f...
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Study unravels antibiotic resistance in MRSA ‘superbug’ infections
FINDINGSResearchers applied a new approach pioneered at UCLA to predict whichmethicillin-resistant Staphylococcus aureus, or MRSA,infections willfail to respond toantibiotic treatment. By focusing on epigenetics — changes to gene expression that can’t be detected by standard DNA sequencing — the study examined how the immune system recognizes dangerous superbugs and works with antibiotics to clear them.BACKGROUNDThe Staphylococcus aureus bacterium can  live harmlessly on a person’s skin and in their nose, occasionally causing mild infections that can be treated with standard antibiotics. When i...
Source: UCLA Newsroom: Health Sciences - March 3, 2021 Category: Universities & Medical Training Source Type: news