New antibiotic clears multi-drug resistant gonorrhea in mice in single dose
(Penn State) A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University. The compound targets a molecular pathway found in bacteria but not humans and could lead to new treatments for gonorrhea and infections from other bacteria, such as tuberculosis and MRSA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2021 Category: International Medicine & Public Health Source Type: news
Estimated Methicillin-Resistant Staphylococcus aureus Decolonization in Intensive Care Units Associated With Single-Application Chlorhexidine Gluconate or Mupirocin, JAMA Network Open 4(3): e210652-e210652
Conclusions and Relevance: These findings suggest that there may be room for significant improvement in anti-MRSA disinfectants, including the compounds themselves and their delivery mechanisms. Despite the decolonization estimates found in this study, these agents are associated with robust outcomes after delays in administration, which may help in alleviating concerns over patient comfort and toxic effects. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news
MRSA prevalence and hospital-level antibiotic use: A retrospective study across 122 acute-care hospitals, Infection Control & Hospital Epidemiology 42(3): 353-355
We evaluated the relationship between local MRSA prevalence rates and antibiotic use across 122 VHA hospitals in 2016. Higher hospital-level MRSA prevalence was associated with significantly higher rates of antibiotic use, even after adjusting for case mix and stewardship strategies. Benchmarking anti-MRSA antibiotic use may need to adjust for MRSA prevalence. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news
Effect of vancomycin loading dose on clinical outcome in critically ill patients with methicillin-resistant Staphylococcus aureus pneumonia, Journal of Thoracic Disease 13(2): 768-777
Background: Vancomycin is the treatment of choice for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Current guidelines recommend giving an initial loading dose (LD) of 25-30 mg/kg to rapidly increase the serum concentration. However, high-quality evidence for the clinical benefit of LD is lacking. Herein, we aim to examine the association between vancomycin LD and clinical outcome. Methods: A retrospective cohort study was conducted on adult patients treated for MRSA pneumonia with vancomycin in medical intensive care units from April 2016 to August 2018. MRSA pneumonia was defined by the Centers f...
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news
Study unravels antibiotic resistance in MRSA ‘superbug’ infections
FINDINGSResearchers applied a new approach pioneered at UCLA to predict whichmethicillin-resistant Staphylococcus aureus, or MRSA,infections willfail to respond toantibiotic treatment. By focusing on epigenetics — changes to gene expression that can’t be detected by standard DNA sequencing — the study examined how the immune system recognizes dangerous superbugs and works with antibiotics to clear them.BACKGROUNDThe Staphylococcus aureus bacterium can live harmlessly on a person’s skin and in their nose, occasionally causing mild infections that can be treated with standard antibiotics. When itentersthe bloodstre...
Source: UCLA Newsroom: Health Sciences - March 3, 2021 Category: Universities & Medical Training Source Type: news
Early Detection and Control of Methicillin resistant Staphylococcus aureus Outbreak in an Intensive Care Unit, Balkan Medical Journal 38(1): 23-28
Conclusion: Molecular typing techniques are the cornerstones for the investigation of outbreaks. Infection control measures, such as enhancing cleaning procedures, promoting hand hygiene, should be enforced in the ICU unit. All patients, including those who have already been discharged to other departments, must be put on contact isolation. HCWs carrying the MRSA strains could be offered decolonization. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Methicillin-resistant Staphylococcus aureus in hip fracture, The bone & joint journal 103-B(1): 170-177
Aims: Infection after surgery increases treatment costs and is associated with increased mortality. Hip fracture patients have historically had high rates of methicillin-resistant Staphylococcus aureus (MRSA) colonization and surgical site infection (SSI). This paper reports the impact of routine MRSA screening and the " cleanyourhands " campaign on rates of MRSA SSI and patient outcome.; Methods: A total of 13,503 patients who presented with a hip fracture over 17 years formed the study population. Multivariable logistic regression was performed to determine risk factors for MRSA and SSI. Autoregressive integrated moving ...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Organization of antibiotic stewardship in Europe: the way to go, Wiener medizinische Wochenschrift 171(Suppl 1): 4-8
It is more than two decades ago that a European Union conference on " The Microbial Threat " hosted by the Danish Government in Copenhagen in September 1998 issued recommendations to encourage good practice in the use of antimicrobial agents and reduce inappropriate prescribing. Essential components of those recommendations were antimicrobial teams in hospitals and the use of feedback to prescribers as well as educational activities. Two decades later, important surveillance systems on both antimicrobial resistance as well as on antibiotic consumption are functioning at the European level and in most European countries; Eu...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Effectiveness of Contact Precautions to Prevent Transmission of Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci in Intensive Care Units, Clinical Infectious Diseases 72: S42-S49
Conclusions We found little evidence that contact precautions implemented during the STAR*ICU trial reduced transmission of MRSA or VRE. We did find important differences in the transmission dynamics between MRSA and VRE. Differences in organism and healthcare setting may impact the efficacy of contact precautions. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Comparative Effectiveness of Switching to Daptomycin Versus Remaining on Vancomycin Among Patients With Methicillin-resistant Staphylococcus aureus (MRSA) Bloodstream Infections, Clinical Infectious Diseases 72: S68-S73
Conclusions Switching to daptomycin within 3 days of initial receipt of vancomycin is associated with lower 30-day mortality among patients with MRSA BSI. This benefit was not seen when the switch occurred later. Future studies should prospectively assess the benefit of early switching from vanco mycin to other anti-MRSA antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news
Livestock workers face high MRSA risk
(Michigan State University) For Michigan State University's Felicia Wu, the surprise isn't that people who work with livestock are at higher risk of picking up antibiotic-resistant bacteria, but instead how much higher their risk levels are. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 28, 2021 Category: Biology Source Type: news
Diclofenac mitigates virulence of multidrug-resistant Staphylococcus aureus. Archives of microbiology 202(10): 2751-2760.
In conclusion, diclofenac can be used in combination with antibiotics as anti-virulence agent against MDR-MRSA which will enhance the ability of immune system to eradicate infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news
High Glucose May Make MRSA More Virulent in Diabetes Patients High Glucose May Make MRSA More Virulent in Diabetes Patients
High glucose levels in the tissue and blood of people with diabetes may help make drug-resistant Staphylococcus aureus infections more aggressive, new mouse research suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 25, 2020 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Understanding lung infections in patients with cystic fibrosis
(University of Warwick) For young people with cystic fibrosis, lung infection with Staphylococcus aureus, MRSA, is common and is treated with antibiotics in the hope that this will prevent a decline in lung function. However there has recently been debate over the role S. aureus plays in CF lung disease. Researchers from the University of Warwick have used a new model of CF lungs which could be used to make better decisions about future use of antibiotics. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 19, 2020 Category: Infectious Diseases Source Type: news
The effectiveness of education of methicillin-resistant Staphylococcus aureus (MRSA) infection prevention and control (IPC) with directive discourse to improve handwashing compliance
The incidence rate of microbial exposure remains high among nurses. Paramedics play a vital role in transmitting the nosocomial infection in the hospital. This research aims to analyze the education effectivity of MRSA IPC with directive discourse to improve handwashing compliance among nurses. This is quasi-experimental research using a pretest –posttest non-control design and has obtained an ethical approval certificate issued by the hospital ethical committee. A research subject is a group of 25 nurses. The data test uses the Wilcoxon test to determine the measuring result of handwashing compliance before and after th...
Source: Current Awareness Service for Health (CASH) - November 18, 2020 Category: Consumer Health News Source Type: news
