Molecules, Vol. 28, Pages 4560: Structural and Spectroscopic Study of New Copper(II) and Zinc(II) Complexes of Coumarin Oxyacetate Ligands and Determination of Their Antimicrobial Activity
ina Georgieva
Tackling antimicrobial resistance is of increasing concern in a post-pandemic world where overuse of antibiotics has increased the threat of another pandemic caused by antimicrobial-resistant pathogens. Derivatives of coumarins, a naturally occurring bioactive compound, and its metal complexes have proven therapeutic potential as antimicrobial agents and in this study a series of copper(II) and zinc(II) complexes of coumarin oxyacetate ligands were synthesised and characterised by spectroscopic techniques (IR, 1H, 13C NMR, UV-Vis) and by X-ray crystallography for two of the zinc complexes. The experimenta...
Source: Molecules - June 5, 2023 Category: Chemistry Authors: Muhammad Mujahid Natasha Trendafilova Georgina Rosair Kevin Kavanagh Maureen Walsh Bernadette S. Creaven Ivelina Georgieva Tags: Article Source Type: research
Superbugs will struggle to evolve resistance to unusual new antibiotic
A much-needed new kind of antibiotic can kill bacteria such as MRSA and works in a way that makes it extremely difficult for resistance to evolve (Source: New Scientist - Health)
Source: New Scientist - Health - June 4, 2023 Category: Consumer Health News Source Type: research
Low-Generation Cationic Phosphorus Dendrimers: Novel Approach to Tackle Drug-Resistant < em > S. aureus < /em > < em > In Vitro < /em > and < em > In Vivo < /em >
Biomacromolecules. 2023 Jun 3. doi: 10.1021/acs.biomac.3c00266. Online ahead of print.ABSTRACTThe incessant, global increase in antimicrobial resistance (AMR) is a very big challenge for healthcare systems. AMR is predicted to grow at an alarming pace, with a dramatic increase in morbidity, mortality, and a 100 trillion US$ loss to the global economy by 2050. The mortality rate caused by methicillin-resistant S. aureus (MRSA) is much higher as compared to infections caused by drug-susceptible S. aureus. Additionally, there is a big paucity of therapeutics available for treatment of serious infections caused by MRSA. Thus, ...
Source: Biomacromolecules - June 3, 2023 Category: Biochemistry Authors: Evgeny Apartsin Abdul Akhir Grace Kaul Deepanshi Saxena Regis Laurent Kishore Kumar Srivastava Serge Mignani Jean-Pierre Majoral Sidharth Chopra Source Type: research
Chromone Derivatives from Whole Plants of Chamaecrista rotundifolia and their Antibacterial Activity
In our search for new bioactive metabolites from plants ofCassia genus, the phytochemical investigation on the whole plants ofC. rotundifolia was carried out, and that led to the isolation of two new (1 and2) and five known (3 –7) chromones. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Interestingly,1 and2 showed good anti-methicillin-resistantStaphylococcus aureus (anti-MRSA) activities with IZD of 13.2 ± 2.4 and 15.8 ± 2.6 mm, respectively. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - June 3, 2023 Category: Chemistry Source Type: research
Characteristics of Virulent ST5-SCCmec II Methicillin-Resistant Staphylococcus aureus Prevalent in a Surgery Ward
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - June 2, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Does dual antiplatelet therapy increase the risk of haematoma enlargement in the acute stage? A retrospective study of the use of stent-assisted coiling versus coiling alone or balloon-assisted coiling for the treatment of ruptured intracranial aneurysms combined with intracranial haematoma
This study aims to identify the efficacy and safety of stent-assisted coiling (SAC) treatment of ruptured intracranial aneurysms (RIAs) combined with intracranial haematoma (ICH) compared to coiling alone or balloon-assisted coiling (non-SAC). A retrospective analysis of 54 consecutive patients receiving endovascular therapy from 2014 to 2020 was performed. The data collected included baseline characteristics, angiographic results, perioperative complications, immediate aneurysm occlusion, clinical outcomes, follow-up at discharge and after 6 months, hospitalisation costs, and inpatient length of stay. Patients were cate...
Source: Neurosurgical Review - June 2, 2023 Category: Neurosurgery Source Type: research
Repurposing CD5789 as an Antimicrobial Agent Against MRSA and Its High Resistant Phonotypes
In this study, CD5789 (trifarotene), a fourth-generation retinoid to be approved by the FDA in 2019 for the topical acne vulgaris regimens, was exhibited antimicrobial activity against MRSA type strains and its clinical isolates with the minimal concentration (MIC) of 2-4 μg/mL and 4-16 μg/mL, respectively, in a dose-dependent manner. By crystal violet staining, we found that CD5789 could inhibit the biofilm formation by MRSA and could further eradicate the pre-formed biofilm at the concentration of 8 μg/mL. By checkerboard dilution assay, sub-MIC of CD5789 showed synergistic antimicrobial effects with sub-MIC of gentam...
Source: Current Microbiology - May 31, 2023 Category: Microbiology Authors: Zhengli Hou Biming Zhang Zuoxun Xiao Cheng Peng Zhengshu Que Ying Xu Zhiqiang Wu Source Type: research
Repurposing CD5789 as an Antimicrobial Agent Against MRSA and Its High Resistant Phonotypes
In this study, CD5789 (trifarotene), a fourth-generation retinoid to be approved by the FDA in 2019 for the topical acne vulgaris regimens, was exhibited antimicrobial activity against MRSA type strains and its clinical isolates with the minimal concentration (MIC) of 2-4 μg/mL and 4-16 μg/mL, respectively, in a dose-dependent manner. By crystal violet staining, we found that CD5789 could inhibit the biofilm formation by MRSA and could further eradicate the pre-formed biofilm at the concentration of 8 μg/mL. By checkerboard dilution assay, sub-MIC of CD5789 showed synergistic antimicrobial effects with sub-MIC of gentam...
Source: Current Microbiology - May 31, 2023 Category: Microbiology Authors: Zhengli Hou Biming Zhang Zuoxun Xiao Cheng Peng Zhengshu Que Ying Xu Zhiqiang Wu Source Type: research
Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages
ConclusionsOur study demonstrated that strong biofilmP. aeruginosa strains, CF isolates, are dominant inducers of M1 macrophages, termed biofilm-associated macrophages (BAMs). We suggest that repolarization of detrimental BAMs might be a new therapeutic strategy to ameliorate the airway damage in CF. (Source: Inflammation Research)
Source: Inflammation Research - May 31, 2023 Category: Research Source Type: research
< em > In Silico < /em > Method for the Screening of Phytochemicals against Methicillin-Resistant < em > Staphylococcus Aureus < /em >
In this study, a total of 284 antimicrobial phytochemicals were screened using the molecular docking approach. The binding affinity of methicillin, -11.241 kcal/mol, was used as the threshold value. The phytochemicals having binding affinities with PBP2a stronger than methicillin were identified, and the drug-likeness properties and toxicities of the screened phytochemicals were calculated. Out of the multiple phytochemicals screened, nine were found as good inhibitors to be PBP2a, among which cyanidin, tetrandrine, cyclomorusin, lipomycin, and morusin showed strong binding potential with the receptor protein. These best-s...
Source: Biomed Res - May 30, 2023 Category: Research Authors: Riaz Tabassum Sumaira Kousar Ghulam Mustafa Amer Jamil Syed Awais Attique Source Type: research
Recent Advances in Pyridine Scaffold: Focus on Chemistry, Synthesis, and Antibacterial Activities
Biomed Res Int. 2023 May 18;2023:9967591. doi: 10.1155/2023/9967591. eCollection 2023.ABSTRACTMultidrug-resistant (MDR) pathogens have created a fatal problem for human health and antimicrobial treatment. Among the currently available antibiotics, many are inactive against MDR pathogens. In this context, heterocyclic compounds/drugs play a vital role. Thus, it is very much essential to explore new research to combat the issue. Of the available nitrogen-bearing heterocyclic compounds/drugs, pyridine derivatives are of special interest due to their solubility. Encouragingly, some of the newly synthesized pyridine compounds/d...
Source: Biomed Res - May 30, 2023 Category: Research Authors: Md Badrul Islam Md Inshaful Islam Nikhil Nath Talha Bin Emran Md Rezaur Rahman Rohit Sharma Mohammed Mahbubul Matin Source Type: research
< em > In Silico < /em > Method for the Screening of Phytochemicals against Methicillin-Resistant < em > Staphylococcus Aureus < /em >
In this study, a total of 284 antimicrobial phytochemicals were screened using the molecular docking approach. The binding affinity of methicillin, -11.241 kcal/mol, was used as the threshold value. The phytochemicals having binding affinities with PBP2a stronger than methicillin were identified, and the drug-likeness properties and toxicities of the screened phytochemicals were calculated. Out of the multiple phytochemicals screened, nine were found as good inhibitors to be PBP2a, among which cyanidin, tetrandrine, cyclomorusin, lipomycin, and morusin showed strong binding potential with the receptor protein. These best-s...
Source: Biomed Res - May 30, 2023 Category: Research Authors: Riaz Tabassum Sumaira Kousar Ghulam Mustafa Amer Jamil Syed Awais Attique Source Type: research
Recent Advances in Pyridine Scaffold: Focus on Chemistry, Synthesis, and Antibacterial Activities
Biomed Res Int. 2023 May 18;2023:9967591. doi: 10.1155/2023/9967591. eCollection 2023.ABSTRACTMultidrug-resistant (MDR) pathogens have created a fatal problem for human health and antimicrobial treatment. Among the currently available antibiotics, many are inactive against MDR pathogens. In this context, heterocyclic compounds/drugs play a vital role. Thus, it is very much essential to explore new research to combat the issue. Of the available nitrogen-bearing heterocyclic compounds/drugs, pyridine derivatives are of special interest due to their solubility. Encouragingly, some of the newly synthesized pyridine compounds/d...
Source: Biomed Res - May 30, 2023 Category: Research Authors: Md Badrul Islam Md Inshaful Islam Nikhil Nath Talha Bin Emran Md Rezaur Rahman Rohit Sharma Mohammed Mahbubul Matin Source Type: research
Conserved loop residues-Tyr < sup > 270 < /sup > and Asn < sup > 372 < /sup > near the catalytic site of the lysostaphin endopeptidase are essential for staphylolytic activity toward pentaglycine binding and catalysis
Biochem Biophys Res Commun. 2023 May 23;668:111-117. doi: 10.1016/j.bbrc.2023.05.085. Online ahead of print.ABSTRACTLysostaphin endopeptidase cleaves pentaglycine cross-bridges found in staphylococcal cell-wall peptidoglycans and proves very effective in combatting methicillin-resistant Staphylococcus aureus. Here, we revealed the functional importance of two loop residues, Tyr270 in loop 1 and Asn372 in loop 4, which are highly conserved among the M23 endopeptidase family and are found close to the Zn2+-coordinating active site. Detailed analyses of the binding groove architecture together with protein-ligand docking show...
Source: Biochemical and Biophysical Research communications - May 28, 2023 Category: Biochemistry Authors: Sathapat Charoenjotivadhanakul Somsri Sakdee Chompounoot Imtong Hui-Chun Li Chanan Angsuthanasombat Source Type: research
Conserved loop residues-Tyr < sup > 270 < /sup > and Asn < sup > 372 < /sup > near the catalytic site of the lysostaphin endopeptidase are essential for staphylolytic activity toward pentaglycine binding and catalysis
Biochem Biophys Res Commun. 2023 May 23;668:111-117. doi: 10.1016/j.bbrc.2023.05.085. Online ahead of print.ABSTRACTLysostaphin endopeptidase cleaves pentaglycine cross-bridges found in staphylococcal cell-wall peptidoglycans and proves very effective in combatting methicillin-resistant Staphylococcus aureus. Here, we revealed the functional importance of two loop residues, Tyr270 in loop 1 and Asn372 in loop 4, which are highly conserved among the M23 endopeptidase family and are found close to the Zn2+-coordinating active site. Detailed analyses of the binding groove architecture together with protein-ligand docking show...
Source: Biochemical and Biophysical Research communications - May 28, 2023 Category: Biochemistry Authors: Sathapat Charoenjotivadhanakul Somsri Sakdee Chompounoot Imtong Hui-Chun Li Chanan Angsuthanasombat Source Type: research
