Challenges of Covid-19 testing.
Authors: Tan GC, Cheong SK Abstract No abstract available. PMID: 32342925 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Properties of Coronavirus and SARS-CoV-2.
Authors: Malik YA Abstract were identified beginning with the discovery of SARS-CoV in 2002. With the recent detection of SARS-CoV-2, there are now seven human coronaviruses. Those that cause mild diseases are the 229E, OC43, NL63 and HKU1, and the pathogenic species are SARS-CoV, MERS-CoV and SARS-CoV-2 Coronaviruses (order Nidovirales, family Coronaviridae, and subfamily Orthocoronavirinae) are spherical (125nm diameter), and enveloped with club-shaped spikes on the surface giving the appearance of a solar corona. Within the helically symmetrical nucleocapsid is the large positive sense, single stranded RNA. Of t...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Diagnostic performance of COVID-19 serology assays.
CONCLUSIONS: There is much to determine regarding the value of serological testing in COVID-19 diagnosis and monitoring. More comprehensive evaluations of their performance are rapidly underway. The use of serology methods requires appropriate interpretations of the results and understanding the strengths and limitations of such tests. PMID: 32342927 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Upper respiratory tract sampling in COVID-19.
Authors: Mawaddah A, Gendeh HS, Lum SG, Marina MB Abstract INTRODUCTION: To review the present literature on upper respiratory tract sampling in COVID-19 and provide recommendations to improve healthcare practices and directions in future studies. METHODS: Twelve relevant manuscripts were sourced from a total of 7288 search results obtained using PubMed, Medline and Google Scholar. The search keywords used were COVID-19, nasopharyngeal, oropharyngeal, swabs, SARS and CoV2. Original manuscripts were obtained and analysed by all authors. The review included manuscripts which have not undergone rigorous peer-revie...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Is this a blast? An illustrated practical review on peripheral blood smear examination in the paediatric patient.
This article provides a practical concise resource that demonstrates the morphological features of the various types of blasts and illustrates the cytologic characteristics that help distinguish them from their benign mimickers in the paediatric population. PMID: 32342929 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Practice and performance of lupus anticoagulant tests: A single centre experience.
CONCLUSION: LA+ patients had higher incidences of thrombosis and CTD as compared to normal and KCT only positive patients. There was no significant difference in clinical characteristics between normal and KCT+ patients which suggests the presence of a high rate of false-positive KCT results. Since confirmatory testing for KCT is not widely used, the option of using another LA screening test method should be considered. In regard to dRVVT testing, confirmatory test should only be performed in patients with prolonged dRVVT screening result which was not corrected upon mixing with normal plasma as required by the Internation...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Evaluation of coagulation factor activity and sterility of thawed fresh frozen plasma during storage up to 5 days at 4 °C.
CONCLUSION: The mean reduction in FII and fibrinogen activities on Day 5 was 5% and 1%, respectively. However, FVIII activity declined significantly by approximately 60% at Day 5. Despite these reductions, thawed plasma stored for up to 5 days at 4°C is still suitable for use as the coagulation factor activity levels still exceed the minimum release criteria recommended in quality assurance regulations. PMID: 32342931 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Medico-legal autopsies of homicidal deaths: A five-year retrospective study in Hospital Sungai Buloh.
CONCLUSIONS: A large number of immigrants in the country have significantly increased the forensic casework. Sharp and blunt objects continue to be the weapon of choice due to its easy accessibility. As domestic violence including fatal spousal and child abuse continue to rise, in-depth study in the area is warranted. PMID: 32342932 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Appropriateness of metformin prescription for type 2 diabetes mellitus patients with chronic kidney disease (Stages 3-5).
Authors: Ramachandran M, Loi B, Mat Ariff N, Ng OC, Zahari Sham SY, Thambiah SC, Samsudin IN Abstract INTRODUCTION: Metformin is the first-line pharmacological therapy for type 2 diabetes mellitus (T2DM). Guidelines recommend metformin to be given at reduced dosages for those with an estimated glomerular filtration rate (eGFR)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Is Procalcitonin more superior to hs-CRP in the diagnosis of infection in diabetic foot ulcer?
This study aimed to compare the performance of PCT and other infection markers in diagnosing infected diabetic foot ulcer (IDFU). MATERIALS AND METHODS: A total of 128 diabetic patients with foot ulcers were recruited and divided into two groups, consisting of 73 patients in the IDFU group and 55 in the non-infected diabetic foot ulcer (NIDFU). The severity of infection in IDFU patients was graded based on the Infectious Disease Society of America-International Working Group on the Diabetic Foot classification. Blood samples from all the patients were collected for measurement of PCT, high sensitivity C-reactive protei...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

High expression of LC3A, LC3B, and p62/SQSTM1 autophagic proteins in human colonic ganglion cells.
CONCLUSIONS: This work highlights the high autophagic activities in human colonic ganglion cells. PMID: 32342935 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Construction of a doxycycline inducible lentivirus that expresses stem cell-specific miR-302 cluster.
DISCUSSION: The efficiency of reprogramming may be improved perhaps by either using a different cell type or a high expression vector with a different type of promoter. PMID: 32342936 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Methanol related death in National Institute of Forensic Medicine, Hospital Kuala Lumpur: A case series.
CONCLUSION: Methanol related deaths are almost always as a result of greed. The running truism is 'methanol poisoning is a result of deliberate addition/adulteration with industrial methanol'. Prevention of the illegal production of methanol and methylated spirits should be established to curb this matter in the future. PMID: 32342937 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Imported Falciparum Malaria: A case series in a tertiary hospital.
DISCUSSION: This case series highlighted the importance of acquiring recent travel history during history taking and having a high index of suspicions on malaria when dealing with feverish patients originated particularly from African countries. PMID: 32342938 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Endocrine mucin-producing sweat gland carcinoma - newly described skin appendageal tumours.
We described a case of this entity, which we believe is the first case to be reported in Malaysia. CASE REPORT: A 59-year-old Chinese male presented with a slow-growing cystic lesion over the left lower lateral canthal region. The lesion became progressively larger and nodular within the last 6 months. Histologically, the lesion is a well-circumscribed intradermal tumour with pushing borders extending into the subcutaneous tissue. The tumour cells were arranged in lobules of solid, papillary and cribriform architecture. The cells displayed uniform, medium-sized, round to oval nuclei with stippled chromatin pattern and ...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Metastatic alveolar rhabdomyosarcoma on the fine-needle aspiration cytology of cervical lymph node in an elderly patient, with FISH confirmation: A case report.
We present a rare case of metastatic alveolar RMS from a nasal primary to cervical lymph nodes (LNs) in an elderly patient, diagnosed on the fine-needle aspiration (FNA) biopsy. Smears showed malignant round cells featuring focal rhabdoid appearance, with rhabdomyoblastic differentiation further supported by immunocytochemical stains. Diagnosis of alveolar RMS was confirmed by fluorescence in situ hybridization (FISH) identifying FOXO1 gene involvement with dual colour break-apart probes at locus 13q14. DISCUSSION: The differential diagnosis for a small round blue cell tumour in the elderly generally includes metastati...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Ewing Sarcoma presenting as a gluteal mass in adult woman: Diagnostic approach and its challenges.
We reported a rare case of Ewing Sarcoma in a 62-year-old woman who had an unusual clinical presentation. She had right painless buttock swelling only for a month. Magnetic resonance imaging (MRI) revealed soft tissue sarcoma originated from right gluteal muscle. The diagnosis of Ewing sarcoma (ES) was made in a limited diagnostic material in an initial tru-cut biopsy, followed by an excision supported by immunohistochemistry (IHC) and Fluorescent In-Situ Hybridization (FISH). DISCUSSION: The purpose of this study is to document ES in an adult woman and its diagnostic challenges in histopathologic perspective. PMID...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Tetraploid/near-tetraploid acute promyelocytic leukaemia with double (15;17) translocation.
Authors: Tay Za K, Jackson N, Chin EFM Abstract A 57-year-old man presented with intermittent fever and bleeding following dental surgery. Peripheral smear and bone marrow aspirate exhibited unusually large and bizarre-looking abnormal cells which were found to be myeloblasts with aberrant CD56 and CD2 expression on immunophenotyping. Fluorescence in situ hybridization analysis revealed an extra RARA gene rearrangement. This finding correlated well with a near-tetraploid karyotype with double t(15;17)(q22;q21). Bcr-3 type PML/ RARA copies were identified in reverse transcriptase-polymerase chain reaction. The diagn...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Collagenofibrotic glomerulopathy- report of a rare renal disease with serial biopsies.
DISCUSSION: The availability of past renal biopsies for reference offered insight into disease progression. From the initial diagnosis of focal segmental glomerulosclerosis to eventually collagenofibrotic glomerulopathy over a time span of more than 10 years, this case highlights the gradual accumulation of collagen fibres in the glomeruli before classical features are apparent. It also emphasises the importance of electron microscopy in the diagnosis of this disease. PMID: 32342943 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration.
We report the case of a 37-year-old woman with nasal deformity and facial pain. The lesion was surgically excised. Histological examination revealed features of EAF with an IgG4/IgG plasma cell ratio ≷73% and 31 IgG4 stained cells per high power field. No clinical or radiological recurrence was detected during follow-up. Serum IgG4 quantification one year after surgery was within normal limits. DISCUSSION: The relationship between both entities may have therapeutic impact because IgG4-RD of the head and neck has a high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this infre...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Early relapse after complete remission of primary plasma cell leukaemia manifesting clonal evolution: A case report.
We report a case of PCL to demonstrate the clonal evolution, resulting in disease relapse after achieving complete remission, and its aggressive nature of the disease, leading to poor clinical outcome. CASE REPORT: A 69-year-old man presented with a three-day-history of worsening generalized body weakness, poor oral intake, nausea, significant loss of weight and lower back pain. He was diagnosed as primary PCL, based on hypercalcaemia, renal insufficiency, anaemia, thrombocytopenia, lytic bone lesions, 24% abnormal plasma cells in peripheral blood, immunophenotype of clonal plasma cells which were positive for CD38, CD...
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Occult primary breast carcinoma presented as an axillary mass: A Diagnostic Challenge.
DISCUSSION: Breast primary must always be considered in the differential diagnosis in patients with sole presentation of axillary lymphadenopathy. The breast-specific immunomarkers play a pivotal role in the diagnosis of ER, PR-negative occult breast cancer. PMID: 32342946 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - April 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Carbonic anhydrase IX immunohistochemistry has potential to predict renal cell carcinoma outcomes: A systematic review and meta-analyses.
CONCLUSION: The measurement of this marker may be beneficial to determine the course of the illness. It is hoped that CAIX can be developed as a specific tissue biomarker for RCC in the near future. PMID: 31901907 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Polymorphisms in the androgen receptor CAG repeat sequence are related to tumour stage but not to ERG or androgen receptor expression in Malaysian men with prostate cancer.
CONCLUSIONS: CAG repeat length is not associated with prostate cancer or expression of ERG or AR. However, ERG appears to be more common in the prostate cancers of Malaysian Indian men than in the prostate cancers of other Malaysian ethnicities and its expression in this study was inversely related to AR expression. PMID: 31901908 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Gleason scores in prostate needle biopsy and prostatectomy specimens in prostatic adenocarcinoma: A correlation study.
This study aims to correlate between Gleason scores of needle biopsies with the corresponding total prostatectomy specimens, and to assess the relationship between the percentage of Gleason 4 tumour pattern (GP4) within Gleason score 7 (GS7) needle biopsy groups with the pathological staging. MATERIALS AND METHODS: Seventy-eight specimens of needle prostate biopsy and its subsequent radical prostatectomy were retrospectively studied. The GSs of the needle biopsy were compared with the corresponding prostatectomy specimens. The percentage of GP4 in GS7 needle biopsy groups was calculated and correlated with the patholog...
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Diagnostic performance of anti-RA33 antibody as a serological marker for rheumatoid arthritis.
CONCLUSION: Anti-RA33 antibody showed good specificity and positive predictive value and could be considered as a potential serological marker for rheumatoid arthritis diagnosis. PMID: 31901910 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Elevated serum rheumatoid factor, anti-citrullinated protein antibodies and active rheumatoid arthritis disease are not associated with chronic periodontitis.
CONCLUSION: In our cohort of RA patients, we did not find significant associations between elevated RF, ACPA, or active RA disease with the presence of CP. There were also no significant associations between elevated RF or ACPA with active RA disease. PMID: 31901911 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

pSTAT3 and MYC in Epstein-Barr virus-positive diffuse large B-cell lymphoma.
CONCLUSION: 66.7% EBV(+)-DLBCL showed the positivity of pSTAT3, which implies the involvement of EBV in constitutive JAK/STAT pathway. 44.5% EBV(+)-DLBCL have co-expression of pSTAT3 and MYC, but all EBV(+)-DLBCL was absence with c-MYC gene rearrangement. The finding of clinical samples might shed lights to the lymphomagenesis of EBV associated with non-GCB subtypes, and the potential therapy for pSTAT3-mediated pathway. PMID: 31901912 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Effects of prolonged isolation in a confined space on status of oxidative stress and prothrombogenesis: In preparation for possible future manned space expedition to Mars.
CONCLUSION: Long-term confinement decreased the risk of prothrombogenesis and this could be attributed to the exercise and diet regime which includes omega-3 fatty acids supplementation given to the crew members during their confinement period. However, oxidative damage could not be excluded and may be attributed to the influence of psychological stress during this prolonged confinement. PMID: 31901913 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

The diagnostic utility of cytokeratin 19 in differentiating malignant from benign thyroid lesions.
This study evaluated the usefulness of Cytokeratin 19 (CK 19) as an immunohistochemical marker to differentiate the different histological types of malignant thyroid neoplasms, particularly papillary thyroid carcinoma (PTC) from benign thyroid lesions. MATERIALS AND METHODS: We collected 54 malignant and 65 benign thyroid lesions diagnosed by histology in Universiti Kebangsaan Malaysia Medical Centre between January 2010 and December 2015. All cases were immunohistochemically stained with CK 19 and evaluated by 3 independent observers. The immunostaining patterns were scored based on the intensity and proportion of sta...
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Parenchyma-stromal interleukin-1 alpha and interleukin-6 overexpressions in ameloblastoma correlate with the aggressive phenotype.
CONCLUSIONS: Overexpression of IL-1α in SMA suggests that this growth factor might play a role in promoting bone resorption and local invasiveness in this subtype. The expression levels of IL-1α and IL-6 in three cellular localizations indicate that parenchymal-stromal components of ameloblastoma interact reciprocally via IL-1α and IL-6 to create a microenvironment conducive for tumour progression. PMID: 31901915 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Selection of reference genes for quantitative studies in acute myeloid leukaemia.
CONCLUSIONS: The selection of best reference gene in qPCR must consider all sample sets. Model-based approaches are important in large candidate gene analysis. This study showed combination of RG SRP14+B2M was the most suitable normalisation factor for qPCR analysis of AML and healthy individuals. PMID: 31901916 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

A radiological and histological comparison of two unusual adrenal incidentalomas.
We describe two unusual and diverse incidental adrenal gland lesions, an adenomatoid nodule and a mature ganglioneuroma. Both are deemed 'indeterminate' on radiological assessment. On histology, an adenomatoid nodule is composed of variably-dilated thin-walled cysts lined by bland flattened cells and solid areas of tubules lined by eosinophilic cells with plump nuclei and prominent nucleoli. The lining cells are immunoreactive for calretinin and WT1 while negative for CK5/6, ERG and CD31. Mature ganglioneuroma features fascicles of bland spindle cells with intermixed mature ganglion cells disposed within a background myxoi...
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

A new complex translocation (8;22;21)(q22;q12;q22) in RUNX1/RUNX1T1 acute myeloid leukaemia.
DISCUSSION: Although the clinical significance of variant t(8;21) is not well delineated, the evaluation of 31 such cases suggests patients with variant t(8;21) have similar prognosis to those with classical t(8;21). PMID: 31901918 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Cytohistology of morule in cribriform-morular variant of papillary thyroid carcinoma.
DISCUSSION: In this case, we performed morule analysis through correlative light and electron microscopy (CLEM), and revealed its ultrastructure. Although CMV is a rare form of thyroid carcinoma, it should be considered along with its distinct clinicopathological characteristics. PMID: 31901919 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Salivary gland anlage tumour of the nasopharynx: A case report and review for histopathological characteristics.
We present a 8-year-old boy complaining from difficulty in breathing and breastfeeding in the neonatal period due to an adenoid-like nasopharyngeal mass. Histological examination revealed solid and cystic squamous nests and numerous duct-like structures within collagenised stroma. Both epithelial and myoepithelial differentiation were noted in the tubular component. DISCUSSION: A review of the clinical and histopathological features of published cases revealed that ancient lesions showed more prominent and complex epithelial component and more collagen rich stroma. We would like to suggest the possibility of salivary g...
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Cellulitis: An unusual manifestation of Neisseria meningitidis infection.
This report provides additional evidence in support of N. meningitidis as a cause of cellulitis. PMID: 31901921 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Thyroid storm: Is there a role for thyroid function test?
DISCUSSION: Plasmapheresis is considered in TS if there is no clinical improvement within 24-48 hours of initial treatment. The improvement in patient's TFT post plasmapheresis signifies its role in treating TS. Unfortunately, there was a delay in commencing plasmapheresis due to haemodynamic instability in this patient. PMID: 31901922 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Cellulitis in human brucellosis: An atypical presentation.
DISCUSSION: This is a case of human brucellosis with atypical cutaneous involvement. PMID: 31901923 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Multiple umbilical cord strictures in a case of intrauterine foetal demise.
We report a case of intrauterine death in a fetus with multiple umbilical cord strictures and vascular thrombosis. CASE REPORT: A 35-year-old woman delivered a stillborn female fetus at 33 weeks of gestation. No fetal anomaly was detected. Examination of the umbilical cord showed multiple strictures, located 4.5 cm and 20 cm from the placental insertion site. Microscopically, the stricture site showed Wharton's jelly being replaced by fibrosis with presence of vascular thrombosis. DISCUSSION: Umbilical cord stricture is uncommon and has been described to be associated with intrauterine fetal death and a possibility...
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Acute Intermittent Porphyria: A rare cause of hyponatraemia.
CONCLUSION: Although rare, AIP should be considered as a cause of hyponatraemia in a patient who presents with signs and/or symptoms that are characteristic of this disease. PMID: 31901925 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Abstracts of the Annual Scientific Meeting of the College of Pathologists, Academy of Medicine: Opportunities and Challenges in Laboratory Medicine 2019.
Authors: Abstract No abstract available. PMID: 31901926 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Abstracts of the 6th Annual Scientific Meeting of International Academy of Pathology Malaysian Division (IAPMD) 2019: Liver and Pancreas Pathology.
Authors: Abstract No abstract available. PMID: 31901927 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Abstracts of the 2nd Biennial Medical & Health Sciences Conference, Universiti Tunku Abdul Rahman 2019.
Abstracts of the 2nd Biennial Medical & Health Sciences Conference, Universiti Tunku Abdul Rahman 2019. Malays J Pathol. 2019 Dec;41(3):431-457 Authors: Abstract No abstract available. PMID: 31901928 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - January 8, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Stature estimation in the South-East Asian population: A systematic review.
CONCLUSION: The most widely used regression equations for stature estimation in South-East Asian population were from the Thailand population. Further research is recommended to develop regression equations for other South-East Asian countries. PMID: 31427544 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - August 21, 2019 Category: Pathology Tags: Malays J Pathol Source Type: research

Screening for microsatellite instability in colorectal carcinoma: Practical utility of immunohistochemistry and PCR with fragment analysis in a diagnostic histopathology setting.
Authors: Cheah PL, Li J, Looi LM, Koh CC, Lau TP, Chang SW, Teoh KH, Mun KS, Nazarina AR Abstract Since 2014, the National Comprehensive Cancer Network (NCCN) has recommended that colorectal carcinoma (CRC) be universally tested for high microsatellite instability (MSI-H) which is present in 15% of such cancers. Fidelity of resultant microsatellites during DNA replication is contingent upon an intact mismatch repair (MMR) system and lack of fidelity can result in tumourigenesis. Prior to commencing routine screening for MSI-H, we assessed two commonly used methods, immunohistochemical (IHC) determination of loss of...
Source: Malaysian Journal of Pathology - August 21, 2019 Category: Pathology Tags: Malays J Pathol Source Type: research

Characterisation of immunogenotypes of diffuse large B-cell lymphoma.
Authors: Phang KC, Hussin NH, Abdul Rahman F, Tizen NMS, Mansoor A, Masir N Abstract INTRODUCTION: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive type of non-Hodgkin lymphoma with variable clinical outcomes. The immunogenotypic features of this heterogeneous disease in Malaysia were not well characterized. MATERIALS & METHODS: In total 141 local series of DLBCL cases from UKM Medical Centre were retrospectively studied. RESULTS: Of these cases, we classified our patients into two subtypes: 32.7% (37/113) GCB and non-GCB 67.3% (76/113) by Hans algorithm and the results showed strong ...
Source: Malaysian Journal of Pathology - August 21, 2019 Category: Pathology Tags: Malays J Pathol Source Type: research

Androgen receptor expression in triple negative breast carcinoma and its association with the clinicopathological parameters.
CONCLUSION: AR is expressed in about one-third of TNBC and loss of AR immunoexpression does not predict adverse clinical outcomes. Larger cohorts for better characterisation of the role of AR immunoexpression in TNBC are warranted. PMID: 31427547 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - August 21, 2019 Category: Pathology Tags: Malays J Pathol Source Type: research

A comparison study of HER2 protein overexpression and its gene status in breast cancer.
Authors: Md Pauzi SH, Saari HN, Roslan MR, Syed Khair Azman Jamalulil SNS, Tauan IS, Mohd Rusli FA, Aizuddin AN Abstract INTRODUCTION: Evaluation of HER2 status in breast cancer using immunohistochemistry (IHC) and in-situ-hybridisation (ISH) study is important to establish prognosis and to select patient for targeted therapy. OBJECTIVE: The study aims to determine the concordance between HER2 protein IHC score and its gene status by dual-colour dual-hapten in-situ-hybridization (DDISH) study. MATERIALS AND METHODS: Retrospective study was performed on 767 referred breast cancer cases over a period of five ...
Source: Malaysian Journal of Pathology - August 21, 2019 Category: Pathology Tags: Malays J Pathol Source Type: research

Molecular detection of Enterobacteriaceae isolates producing blaOXA-48 and blaOXA-181 genes: A single centre study.
CONCLUSIONS: The prevalence of OXA-48 and OXA-181 CRE among all Enterobacteriaceae isolates in our institution is 0.069% and 0.008%, respectively. Nevertheless, our findings suggest that OXA-48 and OXA-181 carbapenemases appear to be important and possibly under-recognised causes of carbapenem resistance in Malaysia. PMID: 31427549 [PubMed - in process] (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - August 21, 2019 Category: Pathology Tags: Malays J Pathol Source Type: research