MicroRNA profiling in complete and partial hydatidiform moles
DISCUSSION: miR-518 was consistently observed to be downregulated in CM versus PM, and CM versus NMA. Further bioinformatic analysis to provide insight into the possible role of these miRNAs in the pathogenesis of HMs, progression of disease and as potential diagnostic biomarkers as well as therapeutic targets for HMs is needed.PMID:38155377 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: W K Chia H X Y Yeoh M Mustangin T Y Khong Y P Wong G C Tan Source Type: research
Epithelial-mesenchymal transition profiles in triple negative breast carcinoma may explain its aggressive nature
Malays J Pathol. 2023 Dec;45(3):363-374.ABSTRACTEpithelial-mesenchymal transition (EMT) is increasingly explored in cancer progression. Considering that triple negative (TN) breast cancer has the poorest survival among molecular subtypes, we investigated 49 TN, 45 luminal and 25 HER2-enriched female breast carcinomas for EMT expression (using E-cadherin and vimentin immunohistochemistry) against lymphovascular and/or lymph node invasion. E-cadherin and vimentin expressions were semi-quantitated for positive- cancer cells (0=0-<1%, 1=1-10%, 2 =11-50%, 3=>50%) and staining intensity (0=negative, 1=weak, 2=moderate, 3=s...
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S F Chiew L M Looi P L Cheah K H Teoh S W Chang S F Abdul Sani Source Type: research
A mutation panel comprising BRAF < sup > V600E < /sup > , NRAS < sup > Q61R < /sup > , and NRAS < sup > Q61H < /sup > replicated retrospective histopathological examination findings in differentiating benign goitre from malignant papillary thyroid cancer in a cohort of Malaysian patients
In conclusion, mutation panel comprising BRAFV600E, NRASQ61R, and NRASQ61H did not discriminate the two PTC subtypes but replicated the retrospective HPE findings in differentiating BTG from PTC. The application of this mutation panel in pre-operative diagnosis of thyroid nodules requires further validation in a larger sample size, preferably incorporating fineneedle aspirate biopsies.PMID:38155379 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: Z H Eng M M Ahmad Jefry K L Ng A Abdul Aziz S Mat Junit Source Type: research
Reference intervals for CTX and P1NP in a multi-ethnic Malaysian cohort
CONCLUSION: The reference intervals for plasma CTX and serum PINP for older Malaysian men and post-menopausal women are somewhat different to other published studies from the region, emphasising the importance of establishing specific reference intervals for each population.PMID:38155380 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: R Z Tan S C Thambiah T P Loh S Vasikaran S S Yeap Source Type: research
Species-specific PCR primers for simultaneous detection of Aspergillus fumigatus, Aspergillus terreus, Candida albicans and Candida glabrata in invasive fungal infections
In conclusion, this quadruplex PCR assay is specific, rapid and reliable to detect A. fumigatus, A. terreus, C. albicans and C. glabrata simultaneously.PMID:38155381 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: Y K M Ismadi S Mohamad A Harun Source Type: research
Clinicopathological characteristics of myelodysplastic syndromes with del(5q) in Taiwan
CONCLUSION: The bone marrow morphology, clinical features, and prognosis of Taiwanese MDS patients with del(5q) were different from those associated with MDS with isolated del(5q) as defined in the current WHO classification. Researchers should compare different geographic regions and racial populations to determine whether geographic and racial differences exist with respect to MDS with del(5q).PMID:38155382 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: C F Yang C Y Hsu L T Hsiao S W Chen S S Chuang Source Type: research
Antifungal susceptibility profile and biofilm-producing capability of Candida tropicalis isolates in a tertiary medical centre
CONCLUSION: The C. tropicalis isolates from our centre were resistant only to triazole agents, with the highest resistance rate being recorded for fluconazole and the lowest for posaconazole. While this is not by itself alarming, the fact that our isolates were prolific biofilm producers means that even azole-susceptible isolates can be paradoxically refractory to antifungal therapy.PMID:38155383 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S D Navarathinam H M Neoh T L Tan A A Wahab M N Mohd Nizam Tzar C H Ding Source Type: research
Placenta microRNA profile of patient with Obstetric Antiphospholipid Syndrome
In this study, we aimed to profile miRNA expressions from placenta tissue of patients with APS. Differentially expressed miRNAs were determined for its targeted genes and pathways. Agilent microarray platform was used to measure placental microRNA expressions between normal placental tissue and those obtained from patients with APS. Differentially expressed miRNAs were detected using GeneSpring GX software 14.2 and sequences were mapped using TargetScan software to generate the predicted target genes. Pathway analysis for the genes was then performed on PANTHER and REACTOME software. Selected miRNAs and their associated ge...
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: M A Mohamad A W Ahmad Asnawi M S Suhiman J Sathar A R Hayati N S Abdul Rahim M A Masri N Abdul Hamid S Nurul Farihah N Mohamad Nor M M Nur Fariha Source Type: research
Epidemiology of neonatal pneumothorax developed spontaneously and during respiratory supports in neonatal intensive care units
CONCLUSIONS: The most common type of pneumothorax was spontaneous in-onset. Neonates on HFV had the highest and those on nCPAPt the lowest rate of pneumothorax. Improving training of resuscitation techniques at birth and strategies of use of invasive modes of respiratory support may reduce incidences of all types of pneumothorax.PMID:38155385 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: N Y Boo E L Lee Ang None The Malaysian National Neonatal Registry Source Type: research
Suction rectal biopsy (SRB) in Hirschsprung's Disease: Is a single macroscopically adequate sample sufficient?
In conclusion, single sample SRBs can be adequately diagnostic and cost-effective in low-resource settings, providing valuable insights for healthcare facilities in Malaysia and other developing countries. The use of adjunctive techniques such as calretinin staining may improve diagnostic accuracy while maintaining cost-effectiveness. Further prospective studies with larger sample sizes are needed to validate these findings.PMID:38155386 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: P K Bal S A Nah W M R Wan Mohamad Noor M T Md Nor S Singaravel W S Tan Y W Tan A Sanmugam Source Type: research
CD47 and CD36 expressions in the placenta of mothers with chorioamnionitis
DISCUSSION: Our study showed CD47 was expressed in the neutrophils and it was associated with poorer perinatal outcomes and it may have a role in the pathogenesis of chorioamnionitis.PMID:38155387 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: B S Hanim R A Rahim M F Mohd Salleh H Zakaria N Abd Shukor Source Type: research
Gastrointestinal stromal tumour in a jejunal diverticulum: The eighth reported case worldwide with a brief review of the literature
Malays J Pathol. 2023 Dec;45(3):473-478.ABSTRACTJejunal diverticulosis is uncommon and so are gastrointestinal stromal tumours (GIST) arising in the jejunum. GIST arising in a jejunal diverticulum is a rarity and to date there are only 7 cases in the English literature. Our case of GIST occurring in a jejunal diverticulum of a 48-year-old lady would be the first reported in Malaysia and the 8th in the world. As in most cases, the clinical presentation and radiological findings of this patient were non-specific. With a history of acute abdominal pain, vomiting and fever, the patient was provisionally diagnosed as a case of ...
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S F Chiew Y F Toh L M Looi P L Cheah Source Type: research
The circulating cells with blast-like morphology in transient abnormal myelopoiesis of Down syndrome are unique and deserve a specific name: Would the term "megakaryogones" serve this purpose?
Malays J Pathol. 2023 Dec;45(3):479-480.ABSTRACTNo abstract available.PMID:38155389 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S B Kahwash K Nicol Source Type: research
Abstracts of the International Congress of Pathology & amp; Laboratory Medicine 2023: Precision Medicine: Revolutionizing Pathology in Genomic Era, organised by the College of Pathologists, Academy of Medicine of Malaysia and at World Trade Centre Kuala Lumpur on 20-22 September 2023
Malays J Pathol. 2023 Dec;45(3):481-566.ABSTRACTNo abstract available.PMID:38155390 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Source Type: research
Abstracts of the National Pathology Conference 2023 by Perak Pathology Services held at Hotel Casuarina Ipoh Perak on 2nd and 3rd August 2023
Malays J Pathol. 2023 Dec;45(3):567-591.ABSTRACTNo abstract available.PMID:38155391 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Source Type: research
