Peptide recovery from chicken feather keratin and their anti-biofilm properties against methicillin-resistant Staphylococcus aureus (MRSA)
In this study, an antibacterial peptide (ABP), with a molecular mass of 3861 Da, was purified from hydrolyzed chicken feathers using a locally isolated keratinolytic bacterium, namelyRhodococcus erythropolis, and its antibacterial and antibiofilm potential were investigated against planktonic and biofilm cells of Methicillin-ResistantStaphylococcus Aureus (MRSA). The results demonstrated that purified ABP showed the growth inhibition of MRSA cells with the minimum inhibitory concentration (MIC) of 45 µg/ml and disrupted MRSA biofilm formation at a concentration of 200 ug/ml, which results were confirmed by scanning elec...
Source: World Journal of Microbiology and Biotechnology - March 5, 2024 Category: Microbiology Source Type: research
Sulfur (S < sup > Ⅵ < /sup > )-containing heterocyclic hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and its SAR
Bioorg Chem. 2024 Feb 25;145:107241. doi: 10.1016/j.bioorg.2024.107241. Online ahead of print.ABSTRACTThe discovery of new small molecule-based inhibitors is an attractive field in medicinal chemistry. Structurally diversified heterocyclic derivatives have been investigated to combat multi-drug resistant bacterial infections and they offers several mechanism of action. Methicillin-resistant Staphylococcus aureus (MRSA) is becoming more and more deadly to humans because of its simple method of transmission, quick development of antibiotic resistance, and ability to cause hard-to-treat skin and filmy diseases. The sulfur (SV...
Source: Bioorganic Chemistry - March 4, 2024 Category: Chemistry Authors: Santosh Kumar Verma Shobith Rangappa Rameshwari Verma Fan Xue Shekhar Verma Kothanahally S Sharath Kumar Kanchugarakoppal S Rangappa Source Type: research
Antimicrobial Resistance and the Prevalence of the Panton-Valentine Leukocidin Gene among Clinical Isolates of < em > Staphylococcus aureus < /em > in Lithuania
This study aimed to determine resistance to antimicrobials of Staphylococcus aureus strains isolated from clinical specimens in Lithuanian hospitals and to identify the genes conferring resistance and virulence. The study was carried out from June 2019 to September 2021. S. aureus strains were isolated from skin, soft tissues, blood, lower respiratory tract, urine and other specimens. Antibiotic susceptibility testing was performed using the disc diffusion method according to EUCAST guidelines. All isolates were analyzed for detection of the ermA, ermC, mecA, mecC, tetK, tetM, and lukF-PV genes by multiplex real-time PCR. ...
Source: Polish Journal of Microbiology - March 4, 2024 Category: Microbiology Authors: Agn ė Kirkliauskienė Jonas Kri ščiūnas Jolanta Miciulevi čienė Daiva Radzi šauskienė Tomas Ka čergius Maksim Bratchikov Lina Kaplerien ė Source Type: research
Sulfur (S < sup > Ⅵ < /sup > )-containing heterocyclic hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and its SAR
Bioorg Chem. 2024 Feb 25;145:107241. doi: 10.1016/j.bioorg.2024.107241. Online ahead of print.ABSTRACTThe discovery of new small molecule-based inhibitors is an attractive field in medicinal chemistry. Structurally diversified heterocyclic derivatives have been investigated to combat multi-drug resistant bacterial infections and they offers several mechanism of action. Methicillin-resistant Staphylococcus aureus (MRSA) is becoming more and more deadly to humans because of its simple method of transmission, quick development of antibiotic resistance, and ability to cause hard-to-treat skin and filmy diseases. The sulfur (SV...
Source: Bioorganic Chemistry - March 4, 2024 Category: Chemistry Authors: Santosh Kumar Verma Shobith Rangappa Rameshwari Verma Fan Xue Shekhar Verma Kothanahally S Sharath Kumar Kanchugarakoppal S Rangappa Source Type: research
Antimicrobial Resistance and the Prevalence of the Panton-Valentine Leukocidin Gene among Clinical Isolates of < em > Staphylococcus aureus < /em > in Lithuania
This study aimed to determine resistance to antimicrobials of Staphylococcus aureus strains isolated from clinical specimens in Lithuanian hospitals and to identify the genes conferring resistance and virulence. The study was carried out from June 2019 to September 2021. S. aureus strains were isolated from skin, soft tissues, blood, lower respiratory tract, urine and other specimens. Antibiotic susceptibility testing was performed using the disc diffusion method according to EUCAST guidelines. All isolates were analyzed for detection of the ermA, ermC, mecA, mecC, tetK, tetM, and lukF-PV genes by multiplex real-time PCR. ...
Source: Polish Journal of Microbiology - March 4, 2024 Category: Microbiology Authors: Agn ė Kirkliauskienė Jonas Kri ščiūnas Jolanta Miciulevi čienė Daiva Radzi šauskienė Tomas Ka čergius Maksim Bratchikov Lina Kaplerien ė Source Type: research
