Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus: a case report
The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been note... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 4, 2024 Category: Infectious Diseases Authors: Sho Shimada, Tetsuo Yamaguchi, Satsuki Mikoshiba, Kazuaki Sato, Takahiro Mitsumura, Kohji Komori, Takashi Yamana, Yuki Iijima, Rie Sakakibara, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi and Yasunari M Tags: Case Report Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
Poly-l-lysine modified MOF nanoparticles with pH/ROS sensitive CIP release and CUR triggered photodynamic therapy against drug-resistant bacterial infection
Int J Biol Macromol. 2024 Apr 1:131330. doi: 10.1016/j.ijbiomac.2024.131330. Online ahead of print.ABSTRACTThe challenge of drug resistance in bacteria caused by the over use of biotics is increasing during the therapy process, which has attracted great attentions of the clinicians and scientists around the world. Recently, photodynamic therapy (PDT) triggered by photosensitizer (PS) has become a promising treatment method because of its high efficacy, easy operation, and low side effect. Herein, the poly-l-lysine (PLL) modified metal-organic framework (MOF) nanoparticles, ZIF/PLL-CIP/CUR, were synthesized to allow both re...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Ya-Li Xiang De-Yu Tang Ling-Ling Yan Luo-Lin Deng Xing-Han Wang Xin-Yang Liu Qing-Han Zhou Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
CXCR2 perturbation promotes < em > Staphylococcus aureus < /em > implant-associated infection
Conclusion. Our results demonstrate that CXCR2 plays an essential role in regulating the severity of S. aureus implant-associated infections. Interestingly, however, perturbation of CXCR2 expression or signalling both resulted in enhanced Cxcr2 transcription and elevated implant-associated bacterial burdens. Thus, CXCR2 appears finely tuned to efficiently recruit effector cells and mediate control of S. aureus biofilm-mediated infection.PMID:38567642 | DOI:10.1099/jmm.0.001821 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 3, 2024 Category: Microbiology Authors: Mike Akaraphanth Tara M Nordgren Casey M Gries Source Type: research
Factors affecting graft healing in laryngotracheal reconstruction: a retrospective single-center experience
ConclusionOpen surgery, double-stage procedure, pediatric age group, and stent duration were not significant risk factors associated with postoperative graft-related complications during LTR in multivariate analysis. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 2, 2024 Category: ENT & OMF Source Type: research
Evaluation of the Effect of < em > Lactobacillus acidophilus < /em > ATCC 4356 Bacteriocin against < em > Staphylococcus aureus < /em >
CONCLUSION: The growth inhibition of S. aureus in overlay soft agar method may be due to the production of bacteriocin-like substances. The overlay soft agar method is a qualitative test, so there is a need for further study to optimize the conditions for the production of bacteriocin-like substances in the culture supernatant and precise comparison between the inhibitory activity and pheromone secretion of different strains.PMID:38559901 | PMC:PMC10980545 | DOI:10.1155/2024/4119960 (Source: Biomed Res)
Source: Biomed Res - April 1, 2024 Category: Research Authors: Zeinab Fagheei Aghmiyuni Horieh Saderi Parviz Owlia Navid Saidi Source Type: research
Molecules, Vol. 29, Pages 1576: Physicochemical Properties and Biological Activities of Quinoa Polysaccharides
In this study, two crude polysaccharide extracts of quinoa (Q-40 and Q-60) were obtained through sequential precipitation with 40% and 60% ethanol, with purities of 58.29% (HPLC) and 62.15% (HPLC) and a protein content of 8.27% and 9.60%, respectively. Monosaccharide analysis revealed that Q-40 contained glucose (Glc), galacturonic acid (GalA), and arabinose (Ara) in a molar ratio of 0.967:0.027:0.006. Q-60 was composed of xylose (xyl), arabinose (Ara), galactose, and galacturonic acid (GalA) with a molar ratio of 0.889:0.036:0.034:0.020. The average molecular weight of Q-40 ranged from 47,484 to 626,488 Da, while Q-60 sho...
Source: Molecules - April 1, 2024 Category: Chemistry Authors: Xucheng Zhu Guiyan Yang Yingbin Shen Liqiong Niu Yao Peng Haiting Chen Haimei Li Xinquan Yang Tags: Article Source Type: research
Automated detection of methicillin-resistant Staphylococcus aureus with the MRSA CHROM imaging application on BD Kiestra Total Lab Automation System
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 1, 2024 Category: Microbiology Authors: Erin McElvaniaSusan MindelJaap LemstraKarin BrandsParul PatelCaryn E. GoodDidier MorelCedrick OrnyJean-Marc VolleMarc DesjardinsDaniel Rhoads1Northshore University Health System, Evanston, Illinois, USA2Becton, Dickinson and Company – Integrated Diagnos Source Type: research
Two undescribed compounds from < em > Aspergillus Niger < /em > , an endophytic fungus isolated from < em > Camellia flavida < /em >
Nat Prod Res. 2024 Mar 29:1-8. doi: 10.1080/14786419.2024.2334325. Online ahead of print.ABSTRACTA new naphtho-γ-pyrone dimer, asperosperma A, and a new methyl nicotinate derivative, asperosperma B, with 12 known compounds were isolated from the endophytic fungus Aspergillus niger from the stem of Camellia flavida. Their structure was elucidated by NMR, ECD spectrum, and HR-ESI-MS data. Asperosperma A exhibited a highly cytotoxicity against H460 and 4T1 cancer cells with the IC50 values were 0.37 ± 0.06 and 2.04 ± 0.79 μM, respectively. Moreover, it showed a highly sensitive against Staphylococcus aureus, Escherichia c...
Source: Natural Product Research - March 29, 2024 Category: Biochemistry Authors: Siyuan Ma Li Ge Hongyu Lu Jianhua Yan Kedi Yang Source Type: research
Rational molecular design converting fascaplysin derivatives to potent broad-spectrum inhibitors against bacterial pathogens via targeting FtsZ
In this study, a new class of marine-derived fascaplysin derivatives has been designed and synthesized by Suzuki-Miyaura cross-coupling. Some compounds exhibited potent bactericidal activities against a panel of Gram-positive (MIC = 0.024-6.25 μg/mL) and Gram-negative (MIC = 1.56-12.5 μg/mL) bacteria including methicillin-resistant S. aureus (MRSA). They exerted their effects by dual action mechanism via disrupting the integrity of the bacterial cell membrane and targeting FtsZ protein. These compounds stimulated polymerization of FtsZ monomers and bundling of the polymers, and stabilized the resulting polymer network, t...
Source: European Journal of Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Xing Zhao Xuanyu Cao Hongda Qiu Weida Liang Yinli Jiang Qiang Wang Weile Wang Chengxi Li Yang Li Bowen Han Keqi Tang Lingling Zhao Xuan Zhang Xiao Wang Hongze Liang Source Type: research
Two undescribed compounds from < em > Aspergillus Niger < /em > , an endophytic fungus isolated from < em > Camellia flavida < /em >
Nat Prod Res. 2024 Mar 29:1-8. doi: 10.1080/14786419.2024.2334325. Online ahead of print.ABSTRACTA new naphtho-γ-pyrone dimer, asperosperma A, and a new methyl nicotinate derivative, asperosperma B, with 12 known compounds were isolated from the endophytic fungus Aspergillus niger from the stem of Camellia flavida. Their structure was elucidated by NMR, ECD spectrum, and HR-ESI-MS data. Asperosperma A exhibited a highly cytotoxicity against H460 and 4T1 cancer cells with the IC50 values were 0.37 ± 0.06 and 2.04 ± 0.79 μM, respectively. Moreover, it showed a highly sensitive against Staphylococcus aureus, Escherichia c...
Source: Natural Product Research - March 29, 2024 Category: Biochemistry Authors: Siyuan Ma Li Ge Hongyu Lu Jianhua Yan Kedi Yang Source Type: research
