Two undescribed compounds from < em > Aspergillus Niger < /em > , an endophytic fungus isolated from < em > Camellia flavida < /em >

Nat Prod Res. 2024 Mar 29:1-8. doi: 10.1080/14786419.2024.2334325. Online ahead of print.ABSTRACTA new naphtho-γ-pyrone dimer, asperosperma A, and a new methyl nicotinate derivative, asperosperma B, with 12 known compounds were isolated from the endophytic fungus Aspergillus niger from the stem of Camellia flavida. Their structure was elucidated by NMR, ECD spectrum, and HR-ESI-MS data. Asperosperma A exhibited a highly cytotoxicity against H460 and 4T1 cancer cells with the IC50 values were 0.37 ± 0.06 and 2.04 ± 0.79 μM, respectively. Moreover, it showed a highly sensitive against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and methicillin-resistant S. aureus.PMID:38551108 | DOI:10.1080/14786419.2024.2334325
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research