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First CPAnet symposium identifies four key research areas for chronic pulmonary aspergillosis
Thu, 11/16/2017 - 15:40News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 16, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

ImmunoPET: the future of lung scans in aspergillosis?
Wed, 11/15/2017 - 11:48News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 15, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

11th Healthcare Infection Society International Conference
Date: Tuesday, November 14, 2017Year: 2018Location: Arena and Convention Centre, LiverpoolContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 14, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

45th Annual Meeting of the European Society for Blood and Marrow Transplantation
Date: Monday, November 13, 2017Year: 2019Location: Frankfurt, GermanyContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Unravelling the pharmacokinetics of triazole antifungals in snakes
Thu, 11/09/2017 - 15:50News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 9, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

First case of echinocandin resistance caused by fks1 mutation found in Aspergillus
Tue, 11/07/2017 - 15:10News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 7, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Vitamin D deficiency and aspergillosis
Mon, 11/06/2017 - 17:31News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 6, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

A. terreus conidia use dendritic cells to their advantage
Thu, 11/02/2017 - 08:35News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 2, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Preclinical Evaluation of the Stability, Safety and Efficacy of CD101, a Novel Echinocandin
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 1, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Postdoctoral research positions
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 1, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Postdoctoral Research Associate I
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 1, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Jekyll-and-Hyde yeast makes chocolate taste great but also causes opportunistic infections
Tue, 10/31/2017 - 16:43News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 31, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

MRC PhD studentship: Definition of the key fungal components that trigger dendritic cells to mediate allergic inflammation
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 30, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Could gamers help tackle aflatoxins?
Fri, 10/27/2017 - 13:57News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 27, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Did Ötzi the Iceman have aspergillosis?
Did Ötzi the Iceman have aspergillosis?Wed, 10/25/2017 - 12:46News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 25, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

59th American Society of Hematology Annual Meeting and Exposition
Date: Tuesday, October 24, 2017Year: 2017Location: Atlanta, USAContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 24, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

North American Cystic Fibrosis Conference 2017
Date: Tuesday, October 24, 2017Year: 2017Location: Indianapolis, USAContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 24, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

British Thoracic Society Summer Meeting 2018
Date: Tuesday, October 24, 2017Year: 2018Location: Manchester, UKContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 24, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

41st European Cystic Fibrosis Conference
Date: Tuesday, October 24, 2017Year: 2018Location: Belgrade, SerbiaContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 24, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

44th Annual Meeting of the European Society for Blood and Marrow Transplantation
Date: Tuesday, October 24, 2017Year: 2018Location: Lisbon, PortugalContent-type: current_conferences (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 24, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

New and emerging treatments for fungal infections.
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Biafungin (CD101), a Novel Echinocandin, Displays a Long Half-life in the Chimpanzee, Suggesting a Once-Weekly IV Dosing Option
Background: The echinocandins are an important class of antifungal agents, but are administered oncedaily by intravenous (IV) infusion. An echinocandin that could be administered once weekly couldfacilitate earlier hospital discharges and could expand usage to indications where daily infusions areimpractical. Biafungin is a highly stable echinocandin for once-weekly IV administration. The compoundwas found to have a spectrum of activity and potency comparable to other echinocandins. In (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Biafungin (CD101), a Novel Echinocandin, Displays an Uncommonly Long Half-life in Multiple Species
Background: The echinocandins are an important class of antifungal agents, but areadministered once daily by intravenous (IV) infusion. An echinocandin that offers a convenientand more economic dosing schedule is desired.Biafungin is a highly stable echinocandin for intermittent IV administration. The compound wasfound to have a long half-life (T1/2), which may greatly reduce costs even as an IV therapythrough less frequent dosing, allowing earlier discharges for patients with negative fungal (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

C101 (biafungin) entry on BIOCENTURY
: http://bciq.biocentury.com/products/biafungin (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species
Novelmacrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agentsagainstwild-type and fluconazoleresistantCandidaspecies. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Latest information on SCY-078 (MK-3118; enfumafungin) from Scynexis
From Scynexis website (as of 20/10/2017): (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates.
MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3)-glucan. We evaluated the invitro activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the FKS gene(s) of Candida spp. and Aspergillus spp.MK-3118 demonstrated enhanced efficacy for most C. albicans and C. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Clone of Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Discovery of Plant Sterol-Derived Gamma-Secretase Modulators by Molecular Editing of a Triterpenoid Glycoside
Excerpt: (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
A series of alpha-asarone-based analogues was designed by conducting docking experiments with published crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a highly hypocholesterolemic in vivo activity in a murine model, as predicted by previous docking studies. In agreement with this model, the polar groups attached to the benzene ring could play a key role in the enzyme binding and probably also in its biological activity, mimicking the HMG-moiety of the natural substrate. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Diagnosis of invasive mould infection in haematology patients: the role of (1,3)-B-D-glucan
Friday, October 20, 2017 - 09:05Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

SCY-078 (Scynexis)
Friday, October 20, 2017 - 09:03Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

‘Fishing rod’ made of DNA for monitoring antifungal concentrations in blood
‘Fishing rod’ made of DNA for monitoring antifungal concentrations in bloodThu, 10/19/2017 - 16:39News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 19, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Postdoctoral Research Associate, Fungal Redox Mechanisms and Biomedical Pathogenesis - USA
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 18, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Killer Fungus to take over Manchester Science Festival
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 17, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Preventing the spread of fungal disease between ʻōhiʻa trees in Hawaiʻi
Tue, 10/17/2017 - 10:41News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 17, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis IV
Monday, October 16, 2017 - 08:36Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis III
Monday, October 16, 2017 - 08:35Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis II
Monday, October 16, 2017 - 08:34Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis I
Monday, October 16, 2017 - 08:32Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Goldilocks and the three azoles
Friday, October 13, 2017 - 15:56Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Resistance epidemiology
Friday, October 13, 2017 - 15:54Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

News from the lab
Friday, October 13, 2017 - 15:51Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

New categories of hematological malignancies at risk for invasive fungal infections
Friday, October 13, 2017 - 15:46Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

New Preparation of Itraconazole (Pulmazole) Gets FDA Approval
Fri, 10/13/2017 - 09:59News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Voriconazole
Friday, October 13, 2017 - 09:48Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Isavuconazole
Friday, October 13, 2017 - 09:46Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news