Hemodynamic Effects of Propofol and Dexmedetomidine in Septic Patients Without Shock
Conclusions and Relevance: A minority of patients with sepsis who received either propofol or dexmedetomidine experienced an event. Patients with sepsis without shock receiving continuous infusions of propofol and dexmedetomidine experienced a negative hemodynamic event at similar frequencies, though the degree of hypotension seen with propofol was greater. The clinical significance of these adverse effects requires cautious use in sepsis and further investigation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Charles City Nurse Anesthetist Sentenced to Nearly Three Years in Federal Prison for Drug Tampering and Diversion Scheme
FDA OCI, Charles City IA, nurse, anesthetist, federal prison, drug tampering, drug diversion, fentanyl, sufentanytl, saline, Christopher West, vials, Propofol, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - June 2, 2020 Category: Medical Law Authors: DOJ Source Type: news

Postpropofol Driving Poses Low Risk to Endoscopy Patients Postpropofol Driving Poses Low Risk to Endoscopy Patients
The 24-hour prohibition on driving recommended after propofol sedation might not be necessary, as driving skills are similar before and after elective outpatient endoscopy, a new study shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 22, 2020 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Key Drugs Join PPEs on List of Front-Line Shortages
Orders shot up exponentially in March for sedatives such as fentanyl, propofol, and midazolam — and order fill rates are dropping. (Source: WebMD Health)
Source: WebMD Health - April 3, 2020 Category: Consumer Health News Source Type: news

Key Drugs Join PPEs on List of Front-Line Shortages Key Drugs Join PPEs on List of Front-Line Shortages
Orders shot up exponentially in March for sedatives such as fentanyl, propofol, and midazolam — and order fill rates are dropping.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - April 3, 2020 Category: Drugs & Pharmacology Tags: Critical Care News Source Type: news

Can science cure a broken heart?
New treatments involving anaesthesia drugs and neurofeedback could soon be used for getting over a breakupNothing is quite as shattering as a broken heart. A bad breakup has been known to trigger a range of psychological and physical symptoms, from nausea and insomnia to clinical depression. In more extreme scenarios,broken heart syndrome– when a person’s heart stops pumping blood properly after an emotional shock – can lead to death.Fortunately, recent breakthroughs suggest we may soon be able to beat it. In March, aSpanish study found propofol, a sedative used for anaesthesia, may also be able to mute t...
Source: Guardian Unlimited Science - February 22, 2020 Category: Science Authors: Dominique Sisley Tags: Neuroscience Relationships Psychology Life and style UK news World news Source Type: news

Doxapram for Low SpO2 During Gastrointestinal Endoscopy Doxapram for Low SpO2 During Gastrointestinal Endoscopy
IV propofol anesthesia is widely used for painless GI endoscopy, but low oxygen saturation may result. Can doxapram alleviate low SpO2 in this scenario?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 16, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Letter to the Editor: Propofol for Migraines Really Works
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - August 1, 2019 Category: Emergency Medicine Tags: Letter to the Editor Source Type: news

Colonoscopy Discharge Readiness After Propofol With DXM Colonoscopy Discharge Readiness After Propofol With DXM
Might a combination of propofol and low-dose dexmedetomidine, compared with propofol alone, decrease the propofol requirement for colonoscopies and improve discharge readiness?Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 1, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Anesthesia Tied to Neurocognitive Impairment in Childhood ALL Survivors
Survivors experience impairment with exposure to propofol, fluranes, longer anesthesia duration (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 25, 2019 Category: Cancer & Oncology Tags: Neurology, Oncology, Pediatrics, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news

Ketofol vs Propofol as an Induction Agent in Pediatrics Ketofol vs Propofol as an Induction Agent in Pediatrics
How does a ketamine-propofol mixture compare with propofol alone in terms of ease of laryngeal mask airway insertion and hemodynamic stability in pediatric patients?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 24, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Marijuana Users May Need More Sedation For Medical Procedures
(CNN) — People who regularly use cannabis may need two times the level of sedation required by nonusers when undergoing medical procedures, a small-scale study finds. Fentanyl, midazolam and propofol, three sedation drugs commonly used during endoscopic procedures, were compared in the research. With “continued increase in legalization and use of cannabis, the field of anesthesia and sedation needs further studies with greater depth,” wrote the authors of the study, published Monday in The Journal of the American Osteopathic Association. Wider use follows legalization Marijuana has gained popularity aroun...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Marijuana Source Type: news

Cannabis users needed up to twice the sedation for medical procedures, small study says
People who regularly use cannabis may need two times the level of sedation required by nonusers when undergoing medical procedures, a small-scale study finds. Fentanyl, midazolam and propofol, three sedation drugs commonly used during endoscopic procedures, were compared in the research. (Source: CNN.com - Health)
Source: CNN.com - Health - April 15, 2019 Category: Consumer Health News Source Type: news

A cure for PTSD? Anesthetic wipes emotional trauma from memory, study finds
Scientists at Universidad Politécnica de Madrid in Spain found that propofol specifically targets emotional memory and disrupts recall for trauma - but not 'emotionally neutral' memories. (Source: the Mail online | Health)
Source: the Mail online | Health - March 20, 2019 Category: Consumer Health News Source Type: news

Propofol vs. Inhalational Agents to Maintain Anesthesia Propofol vs. Inhalational Agents to Maintain Anesthesia
Is anesthesia maintenance with propofol advantageous or beneficial over maintenance with inhalational agents?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 26, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Propofol Tolerance in Children Undergoing Radiation Therapy Propofol Tolerance in Children Undergoing Radiation Therapy
Do children undergoing repeated deep sedation with propofol during proton radiation therapy develop a significant tolerance?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 7, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Patient-Controlled vs Clinician-Controlled Propofol Sedation Patient-Controlled vs Clinician-Controlled Propofol Sedation
How does patient-controlled sedation with propofol compare with clinician-controlled sedation in terms of risks and benefits?Anesthesia & Analgesia (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 2, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Zebrafish research highlights role of locus coeruleus in anesthesia
(Chinese Academy of Sciences Headquarters) Recently, researchers from the Institute of Neuroscience and Zunyi Medical College, by using a larval zebrafish model, revealed that two commonly used intravenous anesthetic drugs, propofol and etomidate, suppress the excitability of locus coeruleus neurons via synergic mechanisms -- thus inhibiting presynaptic excitatory inputs and inducing membrane hyperpolarization of these cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2018 Category: International Medicine & Public Health Source Type: news

Propofol May Decrease Delay in Neurocognitive Recovery
WEDNESDAY, Sept. 12, 2018 -- For older cancer patients undergoing major cancer surgery, propofol-based general anesthesia may reduce the incidence of delayed neurocognitive recovery versus sevoflurane-based general anesthesia, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 12, 2018 Category: Pharmaceuticals Source Type: news

Lasker Awards Honor Development of Propofol, Genetic Research Lasker Awards Honor Development of Propofol, Genetic Research
A third award recognizes pioneering discoveries in RNA biology and passionate support and mentorship of women in science.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 12, 2018 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

British vet wins top research award for breakthrough anaesthetic
John Glen given 2018 Lasker award for discovery of propofol, now used in 90 countries, enabling millions of surgical operations every yearA British veterinarian has won America ’s top biomedical research prize for his discovery of a new way to knock people out.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 11, 2018 Category: Science Authors: Ian Sample Science editor Tags: Medical research Science Source Type: news

Propofol, Breast Cancer Cells, the Immune System, and Outcome Propofol, Breast Cancer Cells, the Immune System, and Outcome
This study reviews the effects of propofol on breast cancer cell biology, the immune system, and post-op pain.BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 23, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Propofol (Diprivan) Safety
Title: Propofol (Diprivan) SafetyCategory: Doctor's& Expert's views on SymptomsCreated: 8/26/2009 12:00:00 AMLast Editorial Review: 6/13/2018 2:55:08 PM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 13, 2018 Category: Drugs & Pharmacology Source Type: news

Using Propofol for Difficult-to-Treat Headaches in the ED Using Propofol for Difficult-to-Treat Headaches in the ED
Find out when and how to use this drug effectively in the emergency department.Medscape Emergency Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 22, 2018 Category: Consumer Health News Tags: Emergency Medicine Commentary Source Type: news

Patients could soon use propofol while undergoing surgery
EXCLUSIVE: Developed by researchers at Nottingham University Hospitals Trust and Nottingham Trent University, it allows patients to control their own doses of propofol. (Source: the Mail online | Health)
Source: the Mail online | Health - February 22, 2018 Category: Consumer Health News Source Type: news

What to D.O.: Low-Dose Propofol Safe for Headache (Yes, Headache)
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - February 1, 2018 Category: Emergency Medicine Tags: What to D.O Source Type: news

Can RNs Bolus Propofol? Can RNs Bolus Propofol?
Nurses often titrate deep sedation, but can they push these drugs if ordered to do so?Medscape Nurses (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 9, 2018 Category: Consumer Health News Tags: Nursing Ask the Expert Source Type: news

Ketamine vs Ketamine and Propofol for Procedural Sedation Ketamine vs Ketamine and Propofol for Procedural Sedation
Might the co-administration of ketamine and propofol for pediatric procedural sedation offer additional benefits over ketamine alone?The Journal of Emergency Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 17, 2017 Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news

We Need to Change Our Approach to Substance Abuse in EMS
Diversion policies may be thought of as the downstream side of a system's approach to controlled substance management. The upstream side, including human resources and occupational health processes for recognizing and testing individuals at risk, may be worth some attention, too. Long-term Consequences Discovering and reporting drug diversions may result in career-ending consequences for our friends and colleagues. However, closing our eyes to this problem may result in even more devastating consequences, including loss of life. It may also lead to potential injury and death of partners, patients, and bystanders, when emer...
Source: JEMS Operations - October 4, 2017 Category: Emergency Medicine Authors: Neal Richmond, MD Tags: Columns Operations Source Type: news

Safe driving after propofol sedation - Summerlin-Grady L, Austin PN, Gabaldon DA.
PURPOSE: Propofol is a short-acting medication with fast cognitive and psychomotor recovery. However, patients are usually instructed not to drive a motor vehicle for 24  hours after receiving propofol. The purpose of this article was to review the evidenc... (Source: SafetyLit)
Source: SafetyLit - September 30, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Ketamine Alone Is Best Sedative for Children's Emergencies Ketamine Alone Is Best Sedative for Children's Emergencies
Ketamine alone was associated with fewer serious adverse events and interventions in children compared with propofol alone or ketamine combined with propofol or fentanyl, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 21, 2017 Category: Consumer Health News Tags: Emergency Medicine News Source Type: news

Dexmedetomidine and Propofol in Monitored Anesthesia Care Dexmedetomidine and Propofol in Monitored Anesthesia Care
Does the combined use of propofol and dexmedetomidine provide cardiovascular stability with a safer profile than either drug used alone?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 31, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Protective Effect of Sevoflurane vs Propofol in HVR Surgery Protective Effect of Sevoflurane vs Propofol in HVR Surgery
This study compared the cardioprotective effect of anesthesia with intravenous propofol versus inhaled sevoflurane in patients undergoing mitral, aortic or tricuspid valve replacement surgery.BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 24, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Sedation After Cardiac Surgery: Is One Drug Preferable? Sedation After Cardiac Surgery: Is One Drug Preferable?
This review compares the use of propofol and dexmedetomidine as adjuncts to fast track the recovery of patients undergoing cardiac surgery. What are their respective advantages and disadvantages?Anesthesia & Analgesia (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 19, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Propofol as suicidal agent or drug of abuse - Hantson P, Bonbled F.
Propofol is a sedative-hypnotic drug that is now widely prescribed for general anaesthesia, long-term sedation, and conscious sedation. Among its main advantages, propofol is a short-acting drug, with predictable pharmacokinetics, and is particularly safe ... (Source: SafetyLit)
Source: SafetyLit - April 21, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Ivaoes Animal Health Launches New Anesthetic Product, Rapanofal(TM) (Propofol Emulsion Injection), the only FDA-approved Propofol Product Formulation Indicated for Use in Cats and Dogs
Rapanofal™ (Propofol Emulsion Injection, 10mg/ml) is the first product of many to come in the Ivaoes Animal Health pipeline of companion animal specialty products, to be launched in the US veterinary healthcare market MIAMI, April 17, 2017 -- (Healthcar... Biopharmaceuticals, Product Launch Ivaoes Animal Health, Tri-Source Pharma, Rapanofal, Propofol (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 17, 2017 Category: Pharmaceuticals Source Type: news

Is Propofol Injection Pain Really Important to Patients? Is Propofol Injection Pain Really Important to Patients?
Pain on injection of propofol is a common occurrence, but do patients generally recall it, and does it negatively impact their experience?BMC Anesthesiology (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 5, 2017 Category: Surgery Tags: Anesthesiology Journal Article Source Type: news

Anesthesia Impact on Arterial O2 During Thoracoscopic Surgery Anesthesia Impact on Arterial O2 During Thoracoscopic Surgery
Is either desflurane-remifentanil or propofol-remifentanil anesthesia preferable in terms of oxygenation during one-lung ventilation for thoracoscopic surgery?BMC Anesthesiology (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - March 15, 2017 Category: Surgery Tags: Anesthesiology Journal Article Source Type: news

Do We Need New Targets for Developing I.V. Anaesthetics? Do We Need New Targets for Developing I.V. Anaesthetics?
Development of new I.V. anesthetic agents has been stagnant since propofol was introduced. In this commentary, the author highlights the need for a renewed focus on novel, tailored I.V. anesthetics.British Journal of Anaesthesia (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 10, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Deaths from propofol abuse : survey of institutes of forensic medicine in Germany, Austria and Switzerland - Maier C, Iwunna J, Tsokos M, Mu ßhoff F.
Previous references suggesting a  high mortality of propofol addiction in medical personnel were mostly based on surveys of the heads of medical departments or case reports; therefore, a questionnaire was sent to 48 forensic medicine departments in German... (Source: SafetyLit)
Source: SafetyLit - January 19, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Diprivan (Propofol) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 18, 2017 Category: Drugs & Pharmacology Source Type: news

Propofol (Propofol Injectable Emulsion) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 18, 2017 Category: Drugs & Pharmacology Source Type: news

Flight Shift
This article does not represent the views or opinions of the USAF, DoD, or the US Government. They are wholly the opinion of the author. Dr. Novak is a former F-15C pilot and current emergency physician in Ohio. Have questions about how combat aviation training could be used in the ED? Email editor@epmonthly.com. The post Flight Shift appeared first on Emergency Physicians Monthly. (Source: EPMonthly.com)
Source: EPMonthly.com - December 31, 2016 Category: Emergency Medicine Authors: Logan Plaster Tags: Uncategorized Source Type: news

Flight Shift
This article does not represent the views or opinions of the USAF, DoD, or the US Government. They are wholly the opinion of the author. Dr. Novak is a former F-15C pilot and current emergency physician in Ohio. Have questions about how combat aviation training could be used in the ED? Email editor@epmonthly.com. The post Flight Shift appeared first on Emergency Physicians Monthly. (Source: EPMonthly.com)
Source: EPMonthly.com - November 21, 2016 Category: Emergency Medicine Authors: Logan Plaster Tags: Uncategorized Source Type: news

Measuring The Cardiovascular Effects of Propofol Anaesthesia Measuring The Cardiovascular Effects of Propofol Anaesthesia
What is the effect of increasing doses of propofol during surgery on global hemodynamics?British Journal of Anaesthesia (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - September 30, 2016 Category: Surgery Tags: Anesthesiology Journal Article Source Type: news

Flight Shift
This article does not represent the views or opinions of the USAF, DoD, or the US Government. They are wholly the opinion of the author. Dr. Novak is a former F-15C pilot and current emergency physician in Ohio. Have questions about how combat aviation training could be used in the ED? Email editor@epmonthly.com. The post Flight Shift appeared first on Emergency Physicians Monthly. (Source: EPMonthly.com)
Source: EPMonthly.com - September 27, 2016 Category: Emergency Medicine Authors: Matt McGahen Tags: Uncategorized Source Type: news

Propofol and Fentanyl Dosing During Colonoscopy in the ElderlyPropofol and Fentanyl Dosing During Colonoscopy in the Elderly
This study examines the pharmacodynamic interaction between fentanyl and propofol when used in combination for colonoscopy in elderly patients. What is the optimal dosing regimen? BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 15, 2016 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Propofol (Propofol Injectable Emulsion) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 13, 2016 Category: Drugs & Pharmacology Source Type: news

AstraZeneca enters commercialisation agreement with Aspen for anaesthetic medicines portfolio
AstraZeneca today announced it has entered into a commercialisation agreement with Aspen Global Incorporated (AGI), part of the Aspen Group, for rights to its global anaesthetics portfolio outside the US. The agreement covers seven established medicines - Diprivan (general anaesthesia), EMLA (topical anaesthetic) and five local anaesthetics (Xylocaine/Xylocard/Xyloproct, Marcaine, Naropin, Carbocaine and Citanest). (Source: World Pharma News)
Source: World Pharma News - June 9, 2016 Category: Pharmaceuticals Tags: Featured AstraZeneca Business and Industry Source Type: news