Peripheral Nerve Block May Cut Opioid Use After Amputation
WEDNESDAY, April 10, 2019 -- Peripheral nerve blockade with regular local anesthetic and liposomal bupivacaine is associated with lower oral morphine equivalent (OME) use at 72 hours after major lower extremity amputation (MLEA), according to a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 10, 2019 Category: Pharmaceuticals Source Type: news

TRPV1 promotes opioid analgesia during inflammation
Pain and inflammation are inherently linked responses to injury, infection, or chronic diseases. Given that acute inflammation in humans or mice enhances the analgesic properties of opioids, there is much interest in determining the inflammatory transducers that prime opioid receptor signaling in primary afferent nociceptors. Here, we found that activation of the transient receptor potential vanilloid type 1 (TRPV1) channel stimulated a mitogen-activated protein kinase (MAPK) signaling pathway that was accompanied by the shuttling of the scaffold protein β-arrestin2 to the nucleus. The nuclear translocation of β-...
Source: Signal Transduction Knowledge Environment - April 2, 2019 Category: Science Authors: Basso, L., Aboushousha, R., Fan, C. Y., Iftinca, M., Melo, H., Flynn, R., Agosti, F., Hollenberg, M. D., Thompson, R., Bourinet, E., Trang, T., Altier, C. Tags: STKE Research Articles Source Type: news

Poppy Seed Overdose Prompts Lawsuit
The parents of a Fayetteville man who died of a morphine overdose after drinking tea he made from poppy seeds he ordered from Amazon are suing the online retailer and Sincerely Nuts Inc. of New York, which marketed and sold the 5-pound bag of poppy seeds. (Source: Arkansas Business - Health Care)
Source: Arkansas Business - Health Care - April 1, 2019 Category: American Health Source Type: news

Tanzania: Tanzania Faces Shortage of Pain-Relieving Morphine
[East African] Tanzania is running out of morphine -- a key reliever of severe pain for patients with terminal illnesses. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 27, 2019 Category: African Health Source Type: news

Statex (Morphine Sulfate Drops, Suppositories, Syrup, Tablets) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Standardized Morphine Infusions for Use in Children Standardized Morphine Infusions for Use in Children
This study investigated the feasibility and safety of quality assured, standardized concentrations of pediatric nurse/patient-controlled morphine infusions, supplied as pre-filled syringes.BMC Anesthesiology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - March 19, 2019 Category: Intensive Care Tags: Anesthesiology Journal Article Source Type: news

The Guardian view on opioids in the the UK: poverty and pain | Editorial
These painkillers don ’t work against chronic pain. The UK must find alternatives to help sufferers in deprived areasPeople in Blackpool are twice as likely as the inhabitants of Wokingham to die before they are 70. Arecent paper which measured the distribution of opioids not by the number of prescriptions, but in equivalent units of morphine, found that NHS prescriptions of opioid painkillers have been generally rising in England and Wales, but have risen most in the north of England and more in poorer areas. Blackpool, again,tops the list. In part this is because poverty is correlated with chronic physical pain: bo...
Source: Guardian Unlimited Science - February 28, 2019 Category: Science Authors: Editorial Tags: Opioids Poverty Social exclusion Society Drugs Science Opioids crisis US news NHS Health GPs Doctors Conservatives Politics Austerity Economics Business Source Type: news

Prescription painkillers do more harm than good for back pain
(Natural News) From over-the-counter (OTC) painkillers like ibuprofen, naproxen, and aspirin to prescription drugs like tramadol, morphine, and hydrocodone, these meds are omnipresent in modern American life. They have become more widely used than tobacco, according to a Substance Abuse and Mental Health Services Administration report. In 2015, more than 36 percent of Americans, aged 12... (Source: NaturalNews.com)
Source: NaturalNews.com - February 28, 2019 Category: Consumer Health News Source Type: news

Opiate prescribing practices after common isolated lower extremity injuries - Rodriguez-Buitrago A, Attum B, Enata N, Evans A, Okwumabua E, Gajari V, Obremskey WT, Jahangir A.
OBJECTIVE: This retrospective study aimed at identifying opiate prescribing practices, the number of morphine milligram equivalents (MMEs) prescribed by orthopaedic and nonorthopaedic providers in patients with operatively treated isolated lower extremity ... (Source: SafetyLit)
Source: SafetyLit - February 25, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Allegations Against the Maker of OxyContin Are Piling Up. Here ’s What They Could Mean for the Billionaire Family Behind Purdue Pharma
Executives from Purdue Pharma, the manufacturer of the powerful opioid painkiller OxyContin, admitted in federal court in 2007 that Purdue’s marketing practices and interactions with doctors had understated the strength and addictive potential of the drug — an omission that many experts believe contributed to an opioid epidemic that claimed nearly 50,000 American lives in 2017 alone. But on Thursday, the release of a previously sealed deposition from 2015 showed that Purdue executives knew of OxyContin’s strength long before that $600 million settlement. The deposition, which had been filed in court, reve...
Source: TIME: Health - February 22, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Drugs healthytime onetime Source Type: news

'Alarming' number of people received restricted fentanyl, study says
An "alarming" number of US patients received a highly potent form of opioid that is 100 times more powerful than morphine and that they never should have been prescribed, according to a new study. (Source: CNN.com - Health)
Source: CNN.com - Health - February 19, 2019 Category: Consumer Health News Source Type: news

One size does NOT fit all when it comes to medicine: Genetic study finds wide variation in risk of addiction when opioids are used for chronic pain
(Natural News) Chronic pain often pushes people to use opioid painkillers such as morphine and Vicodin, which may leave sufferers with an increased risk of prescription opioid addiction. Millions of Americans see their doctors for chronic pains, and doctors, in turn, resolve to prescribe these medications for immediate relief. Researchers from Florida Atlantic University (FAU) are... (Source: NaturalNews.com)
Source: NaturalNews.com - February 15, 2019 Category: Consumer Health News Source Type: news

Ibuprofen a'Reasonable' Option for Early Pain Control After Hip Replacement Ibuprofen a'Reasonable' Option for Early Pain Control After Hip Replacement
Combining paracetamol (acetaminophen) with ibuprofen does not cut postoperative use of morphine in a clinically meaningful way relative to ibuprofen alone, in patients undergoing total hip arthroplasty (THA), results of a Danish randomized trial suggest.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 14, 2019 Category: Orthopaedics Tags: Orthopaedics News Source Type: news

Experimental 'nano-painkiller' is more effective and less addictive than morphine
Researchers at the University of Delaware and in France re-engineered naturally occurring compounds to treat pain with longer lasting effects than morphine but minimal addiction risk. (Source: the Mail online | Health)
Source: the Mail online | Health - February 13, 2019 Category: Consumer Health News Source Type: news

Miracle treatment or dangerous drug? Indonesian growers cash in on Kratom as it takes hold in the US
Many have died, suffered extreme reactions and overdoses to the morphine-like substance. It is grown in Indonesia were its use is banned but exports are allowed. (Source: the Mail online | Health)
Source: the Mail online | Health - February 9, 2019 Category: Consumer Health News Source Type: news

Verily Forges Rehabilitation Center to Fight Opioid Crisis
Verily is responding to the opioid crisis through the planned creation of a high-tech rehabilitation center. Dubbed One Fifteen, the proposed rehabilitation center is part of a partnership Verily has with healthcare providers Kettering Health Network and Premier Health, and in partnership with Alexandria Real Estate Equities. One Fifteen will open in Dayton, OH. Verily revealed plans surrounding the center on a blog post dated Feb. 6, 2019. The idea for One Fifteen came from a team of clinicians, engineers, and health systems specialists. The group undertook an assessment of the opioid crisis and uncovered a complex set of...
Source: MDDI - February 8, 2019 Category: Medical Devices Authors: Omar Ford Tags: Digital Health Source Type: news

Carfentanil: a narrative review of its pharmacology and public health concerns - Leen JLS, Juurlink DN.
Carfentanil is a synthetic fentanyl analogue approved for veterinary use. It is a mu-opioid receptor agonist with an estimated analgesic potency approximately 10,000 times that of morphine and 20-30 times that of fentanyl, based on animal studies. Since 20... (Source: SafetyLit)
Source: SafetyLit - January 24, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Buprenorphine May Best Morphine for Treating NAS
(MedPage Today) -- But questions raised about high risk of study bias in meta-analysis (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - January 22, 2019 Category: American Health Source Type: news

Medtronic ‘Embraces’ its Role in the Opioid Crisis Fight
Not many medtech companies have the reach and scale of Medtronic. Yet, the Dublin-based firm is in the same position as any other device firm when it comes to the awareness and acceptance of alternatives to oral opioids. Medtronic is hoping to change this with the help of its newly-launched Embrace Targeted Drug Delivery (TDD)clinical study. The 100-patient trial is a post-market study set to evaluate the use of the SynhroMed II intrathecal drug delivery system for patients with chronic intractable non-malignant primary back pain with or without leg pain. The first patient was enrolled in Embrace TDD last week. â ...
Source: MDDI - January 18, 2019 Category: Medical Devices Authors: Omar Ford Tags: Business Source Type: news

Focusing on usability can limit medical device recalls: Here ’ s how
By Stephanie Van Ness and Rex Palmer of Boston UX Building great software has always been challenging. Building software that safeguards patients while flawlessly controlling sensitive embedded and connected medical devices — from room-sized proton radiation systems to portable automatic external defibrillators (AED) — magnifies the challenge. It should be no surprise that design issues cause many device recalls. So how do you mitigate potential problems when designing a medical device user interface (UI)? Begin with a strong focus on usability. The importance of usability According to ...
Source: Mass Device - January 17, 2019 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog Boston UX Source Type: news

Doctors in poor areas prescribe up to FOUR times as many high-strength opioid painkillers
Researchers from the universities of Nottingham and Manchester found doctors in Blackpool and St Helens prescribe the most opioid painkillers such as codeine, tramadol and morphine. (Source: the Mail online | Health)
Source: the Mail online | Health - January 15, 2019 Category: Consumer Health News Source Type: news

Metabolism and metabolomics of opiates: a long way of forensic implications to unravel - Dinis-Oliveira RJ.
Opium poppy has important medical, socioeconomic, forensic and political implications. More than 80 benzylisoquinoline alkaloids have been described, many of them with relevant therapeutic properties such as morphine, codeine, papaverine and noscapine. Her... (Source: SafetyLit)
Source: SafetyLit - January 11, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Comparison between intravenous morphine versus fentanyl in acute pain relief in drug abusers with acute limb traumatic injury - Vahedi HSM, Hajebi H, Vahidi E, Nejati A, Saeedi M.
BACKGROUND: Rapid and effective pain relief in acute traumatic limb injuries (ATLI) is one of the most important roles of emergency physicians. In these situations, opioid addiction is an important concern because of the dependency on opioids. The study ai... (Source: SafetyLit)
Source: SafetyLit - January 3, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Morphine concentrations in human urine following poppy seed paste consumption - Özbunar E, Aydoğdu M, Döğer R, Bostancı Hİ, Koruyucu M, Akgür SA.
Papaver somniferum (opium poppy) is one of the world's oldest medicinal plants which are widely used for medicinal, nutritive and scientific purposes. Turkey is one of the major legal opium poppy producer countries in the world and the seed paste of the po... (Source: SafetyLit)
Source: SafetyLit - December 26, 2018 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

How tiny implant could help thousands blighted by crippling abdominal pain  
The matchbox box-sized device is being trialled on 30 NHS patients with a common condition of the pancreas and could slash the use of potent painkilling drugs like morphine. (Source: the Mail online | Health)
Source: the Mail online | Health - December 22, 2018 Category: Consumer Health News Source Type: news

Industrially processed fructose is just as addictive as alcohol and even morphine, concludes study
(Natural News) Sweets are well-loved by millions of people across the world, with at least 50 pounds of processed fructose being consumed per year. If you find yourself constantly eating and craving sweets, don’t immediately dismiss this as nothing serious. Studies have shown that industrially processed fructose is just as addictive and damaging as alcohol. Fructose,... (Source: NaturalNews.com)
Source: NaturalNews.com - December 21, 2018 Category: Consumer Health News Source Type: news

The Weaponization of Narcan
Narcan, the trade name of the opiate antidote naloxone, has become a part of the modern lexicon. It can even be found in the Urban Dictionary. Although initially a noun, it is now a widely used verb as in, “I Narcanned that patient,” or, “I Narcanned your Honor Student.” Narcan is so effective that we have even dreamed up imaginary clinical situations to administer it. YouTube is full of videos of police officers giving themselves or colleagues Narcan for suspected “fentanyl exposure.” A popular video shows a police officer giving Narcan to another officer after exposure to what was late...
Source: JEMS Special Topics - December 21, 2018 Category: Emergency Medicine Authors: Bryan Bledsoe, DO, FACEP, FAEMS Tags: Airway & Respiratory Exclusive Articles Columns Source Type: news

MORE DANGEROUS than a nuclear weapon, Fentanyl – the heroin-based prescription painkiller – could be the next WMD
(Natural News) Opioids are the class of pain-relieving drugs made from the illegal and deadly drug heroin. Fentanyl is by far the most dangerous, but you’ve certainly heard of some other popular ones, including oxycodone (a.k.a. Oxycontin), hydrocodone (a.k.a. Vicodin), morphine and codeine. Fentanyl is so strong that just a few too many milligrams can... (Source: NaturalNews.com)
Source: NaturalNews.com - December 19, 2018 Category: Consumer Health News Source Type: news

Vaccine could help address the opioid epidemic
(American College of Neuropsychopharmacology) Synthetic psychoactive drugs have become a serious public health threat in recent years. This is particularly true of the fentanyls, a large family of synthetic opioids, which can be up to 10,000 times more potent than morphine. Synthetic opioids are highly addictive and, because of their potency, often prove fatal: among the roughly 72,000 drug overdose deaths in the US in 2017, some 30,000 were related to synthetic opioids. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 13, 2018 Category: International Medicine & Public Health Source Type: news

Fentanyl Surpasses Heroin As Drug Most Often Involved In Deadly Overdoses
When fentanyl, a synthetic opioid 50 to 100 times more powerful than morphine, infiltrated the drug supply in the U.S. it had an immediate, dramatic effect on the overdose rate. (Image credit: Towfiqu Photography/Getty Images) (Source: NPR Health and Science)
Source: NPR Health and Science - December 13, 2018 Category: Consumer Health News Authors: Laurel Wamsley Source Type: news

Overdose Deaths Involving Fentanyl Doubled Every Year From 2013 to 2016
Drug overdose deaths involving the potent synthetic opioid fentanyl are on the rise, and the number of fentanyl-related deaths roughly doubled each year from 2013 through 2016, according to new federal data. Researchers from the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics (NCHS) reviewed death certificates filed from 2011 to 2016 to find out which drugs were mentioned most frequently each year. During this time period, drug overdose deaths increased from 41,340 in 2011 to 63,632 in 2016. Just as striking as the overall uptick, however, was the sharp increase in deaths invo...
Source: TIME: Health - December 12, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime public health Source Type: news

SAPB for Minimal Invasive Heart Surgery SAPB for Minimal Invasive Heart Surgery
Can serratus anterior plane block reduce morphine consumption and improve management of post-operative pain when compared with continuous wound infiltration following minimal invasive heart surgery?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 7, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

China Has Promised to Crack Down on Fentanyl. Here ’s What That Could Mean for Overdose Deaths in the U.S.
As part of a wide-ranging deal between President Donald Trump and Chinese leader Xi Jinping, China has reportedly pledged to designate the potent synthetic opioid fentanyl and similar drugs as controlled substances, subjecting those who sell them to harsher punishments and potentially slowing their flow into the U.S. Last month, a Congressional commission said China — which it previously called the “largest source of illicit fentanyl and fentanyl-like substances in the United States” — was not doing enough to stop the drug and its related analogs from reaching U.S. borders. The Trump Administration ...
Source: TIME: Health - December 3, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized China healthytime onetime public health Source Type: news

Fentanyl in cocaine: The deadly truth of new drugs cocktail
A surge in cocaine deaths is being blamed on fentanyl, a synthetic opioid far stronger than morphine. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - November 26, 2018 Category: Consumer Health News Source Type: news

Study Shows Cancer Patients Can Benefit from Opioid Switching
Switching from one prescription opioid to another often solves the problem of debilitating side effects or inadequate pain relief, according to a recent study involving a wide range of cancer patients. Opioids are not all the same. And neither are those they are helping. Despite the increasing government restrictions and the frenzy over potential abuse, opioids can be a lifesaver for a mesothelioma patient finding the right fit. “I’ve been through both sides of that switching issue,” said Tim Crisler, a 16-year pleural mesothelioma survivor told The Mesothelioma Center at Asbestos.com. “It worked gr...
Source: Asbestos and Mesothelioma News - November 26, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Zapping the brain can treat chronic pain (and the results kick-in after just one 40 minute session)
Doctors at the University of North Carolina say the therapy could be a cheap alternative to reduce the use of opioids, such as morphine, which can have severe side effects. (Source: the Mail online | Health)
Source: the Mail online | Health - November 9, 2018 Category: Consumer Health News Source Type: news

Amid Deepening Addiction Crisis, FDA Approves Powerful New Opioid
(CNN) — Despite the ongoing opioid crisis plaguing the nation, the US Food and Drug Administration on Friday approved a new opioid medication five to 10 times more powerful than fentanyl. Dsuvia, made by AcelRx Pharmaceuticals Inc., is a tablet in a single-dose, prefilled applicator to be administered under the tongue by health care providers to patients in settings such as hospitals, surgical centers and emergency rooms, according to the company. FDA Commissioner Dr. Scott Gottlieb was quick to defended the approval in a statement Friday: “The agency is taking new steps to more actively confront this crisis, ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 5, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Local TV opioids Source Type: news

WATCH: FDA approved new opioid drug called Dsuvia
The drug is 10 times stronger than fentanyl, which is already up to 1,000 times stronger than morphine. (Source: ABC News: Health)
Source: ABC News: Health - November 3, 2018 Category: Consumer Health News Tags: GMA Source Type: news

FDA approves opioid pill 1,000 times stronger than morphine despite warnings 'it will kill people'
Despite criticism, on Friday, the FDA approved a pill form of sufentanil, a cousin of fentanyl estimated to be as much as 10 times as powerful as the drug that has fueled the opioid epidemic. (Source: the Mail online | Health)
Source: the Mail online | Health - November 3, 2018 Category: Consumer Health News Source Type: news

WATCH: FDA approves powerful, controversial new painkiller
Dsuvia is an opioid taken in pill form that is 10 times stronger than Fentanyl and up to 1,000 times stronger than morphine. (Source: ABC News: Health)
Source: ABC News: Health - November 3, 2018 Category: Consumer Health News Tags: WNT Source Type: news

Rx Switching at the Pharmacy: What would you say?
Should you substitute  Vigamox with Moxeza? How about Oxycontin with MS Contin? Take our quick, 4-question quiz to find out.  (Source: ConsultantLive)
Source: ConsultantLive - November 1, 2018 Category: Internal Medicine Authors: Alex Evans, PharmD, BCGP Source Type: news

Comparison of Oxycodone and Morphine for Cancer Pain Comparison of Oxycodone and Morphine for Cancer Pain
Do oxycodone and morphine differ significantly in their analgesic efficacy or tolerability when used as first-line therapy for patients with moderate to severe cancer pain?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 31, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Fake drugs: The global industry putting your life at risk
In late 2012, 60 people died in two cities in Pakistan after drinking cough syrup to get high. Tests in Pakistan revealed that the medicines seemed to contain the correct amount of active ingredient, but further tests revealed something that was not supposed to be there. Levomethorphan, a chemical five times stronger than morphine, was the contaminant that had caused the deaths. (Source: CNN.com - Health)
Source: CNN.com - Health - October 30, 2018 Category: Consumer Health News Source Type: news

FDA committee votes to approve Opioid tablet 1,000 times stronger than morphine
A Food and Drug Adminstration's advisory committee voted in favor of the approval of a sufentanil tablet, an opioid 10 times stronger than fentanyl. The committee's chair warns doing so will fuel the crisis. (Source: the Mail online | Health)
Source: the Mail online | Health - October 22, 2018 Category: Consumer Health News Source Type: news

FDA mulls approval for opioid 500 times stronger than morphine
An FDA committee has recommended approval of a new synthetic opioid much stronger than other pain killers on the market. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - October 22, 2018 Category: Pharmaceuticals Source Type: news

Heroin vaccine technology advances as researchers are awarded grant for further testing
(The U.S. Military HIV Research Program (MHRP)) Researchers at the U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (WRAIR) and SUNY Upstate Medical University in Syracuse, N.Y., have been awarded a grant to advance an experimental heroin vaccine through Phase I/IIa clinical trials to assess both its safety and its efficacy against a morphine challenge. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2018 Category: International Medicine & Public Health Source Type: news

Ketamine is a safe, effective alternative to opioids in treating acute pain in the ED
(Society for Academic Emergency Medicine) Intravenous, low-dose ketamine (LDK) is as effective as intravenous morphine in the control of acute pain in adults in the emergency department (ED). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 15, 2018 Category: International Medicine & Public Health Source Type: news

GP practices prescribe controlled drugs electronically in NHS Digital pilot
A small number of GP practices have been selected to electronically prescribe controlled drugs (CDs) as part of a pilot scheme, NHS Digital has announced.  A total of 10 practices based in Yorkshire, the North West and London and using the Emis Health and Vision systems, started with the pilot on 2 October.  They are now able to prescribe drugs such as morphine and tramadol that it was previously not possible to send through the electronic prescription service (EPS). Hide related content:  Show related contentread more (Source: Management in Practice)
Source: Management in Practice - October 8, 2018 Category: Practice Management Authors: vfiore Tags: *** Editor ' s Pick Patients Latest News Source Type: news

'I'll keep taking your blue pills'
Jim had been relying on morphine to cope with his back pain - but it turned out a dummy pill worked just as well. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 4, 2018 Category: Consumer Health News Source Type: news