Researchers develop a yeast-based platform to boost production of rare natural molecules
(Concordia University) Researchers at Concordia University in Montreal and in Berkeley, California outline a method to synthesize complex bioactive molecules much more quickly and efficiently. Using cutting-edge synthetic biology approaches, They were able to produce a large amount of benzylisoquinoline alkaloid (BIA) to synthesize an array of natural and new-to-nature chemical structures in a yeast-based platform. This can provide a blueprint for the large-scale production of thousands of products, including the opioid analgesics morphine and codeine. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 27, 2020 Category: Biology Source Type: news

Morphine Sulfate Tablets (morphone sulfate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 14, 2020 Category: Drugs & Pharmacology Source Type: news

Hypnosis May Relieve Pain, Morphine Use at AFlut Ablation Hypnosis May Relieve Pain, Morphine Use at AFlut Ablation
Standard pain-control methods can pose some risks, so alternatives that curb opiate use during ablation would be welcome, as would larger trials confirming a study hinting at a role for hypnotism.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - July 8, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Eastern Iowa Nurse Sentenced to Federal Prison for Stealing Patient ’s Pain Medication
FDA OCI, ICU nurse, intensive care, pain medications, unconscious patient, IV line, Kelly Postel, Anamosa IA, morphine, fentanyl, hospital pharmacy, Cedar Rapids hospital, syringe, forfeit license, sentence, stealing, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - June 26, 2020 Category: Medical Law Authors: DOJ Source Type: news

Nigeria: Non-Medical Use of Prescription Drugs Among Skilled Workers - a Pilot Study
[The Conversation Africa] More than ever, the world is facing a challenge of non-medical use of prescription drugs among people of all ages, genders and occupations. Evidence shows that pharmaceutical opioids (tramadol, codeine, or morphine), barbiturates such as pentobarbital sodium, benzodiazepines (diazepam and alprazolam), and amphetamines are the most common types of prescription medication used in a non-medical context. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 25, 2020 Category: African Health Source Type: news

Patient-Controlled Subcutaneous Sufentanil Bests Morphine in Advanced Cancer Patient-Controlled Subcutaneous Sufentanil Bests Morphine in Advanced Cancer
In patients with stage III-IV cancer, patient-controlled subcutaneous analgesia (PCSA) with sufentanil led to better pain control and quality of life than morphine in a randomized trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 17, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Registered Nurse Pleads Guilty to Drug Diversion Charge
Haverhill MA, registered nurse, guilty, plea, Brianna Duffy, tampering, Hunt Nursing and Rehabilitation Center, Danvers MA, morphine, patient, diluting, Maplewood Care and Rehabilitation Center, Amesbury MA, diverted, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - June 16, 2020 Category: Medical Law Authors: DOJ Source Type: news

If Prescribed Opioids for Pain, Ask Lots of Questions: FDA
THURSDAY, May 21, 2020 -- If your doctor prescribes opioid painkillers such as hydrocodone, oxycodone, codeine or morphine for you, there are a number of questions you should ask, the U.S. Food and Drug Administration advises. Opioids can be used... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 21, 2020 Category: General Medicine Source Type: news

Heating poppy seeds, but not baking them in muffins, reduces opiate levels
(American Chemical Society) You might have heard the advice to avoid eating a poppy seed bagel or muffin before a drug screen, lest you test positive for opiates. This urban legend is rooted in truth because the tiny black seeds contain small amounts of morphine and codeine that can show up in a drug test. Now, researchers reporting in ACS'   Journal of Agricultural and Food Chemistry have studied how different treatments affect levels of opiates in poppy seeds. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 20, 2020 Category: International Medicine & Public Health Source Type: news

Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway
Morphine and other opioids are commonly used to treat pain despite their numerous adverse side effects. Modulating μ-opioid receptor (MOR) signaling is one way to potentially improve opioid therapy. In mice, the chaperone protein Hsp90 mediates MOR signaling within the brain. Here, we found that inhibiting Hsp90 specifically in the spinal cord enhanced the antinociceptive effects of morphine in mice. Intrathecal, but not systemic, administration of the Hsp90 inhibitors 17-AAG or KU-32 amplified the effects of morphine in suppressing sensitivity to both thermal and mechanical stimuli in mice. Hsp90 inhibition enabled opi...
Source: Signal Transduction Knowledge Environment - May 5, 2020 Category: Science Authors: Duron, D. I., Lei, W., Barker, N. K., Stine, C., Mishra, S., Blagg, B. S. J., Langlais, P. R., Streicher, J. M. Tags: STKE Research Articles Source Type: news

Nurse Given Prison Sentence for Drug Theft and Tampering
nurse, prison, drug theft, tampering, Katie Boll, Manchester IA, morphine, hydrocodone, oxycodone, codeine, tramadol, nursing home, mouthwash, fraud, deception, subterfuge, 48 months prison (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - April 7, 2020 Category: Medical Law Authors: DOJ Source Type: news

Reducing Postop Nausea After Gynecological Laparoscopic Surgery Reducing Postop Nausea After Gynecological Laparoscopic Surgery
This study evaluated the efficacy of adjunctive dexmedetomidine to morphine-based analgesia for postoperative nausea and vomiting prophylaxis in women undergoing gynecological laparoscopic surgery.BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 23, 2020 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Long-term Opioid Use in Men Linked to Hypogonadism Long-term Opioid Use in Men Linked to Hypogonadism
Maximum morphine equivalent daily dose and the odds of developing hypogonadism in men taking long-term opioids.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - March 9, 2020 Category: Endocrinology Tags: Neurology & Neurosurgery News Source Type: news

Kenya: Kemsa Laxity, Red Tape Worsen Patients' Pain
[Nation] A weak healthcare system and systemic bureaucracy in government institutions has led to the suffering of thousands of terminally-ill patients for close to a year now due to shortage of oral morphine. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 18, 2020 Category: African Health Source Type: news

More than half of US opioid prescriptions for dental procedures exceeded 3-day supply recommendations from CDC 2016 guidelines
New largescale study in the American Journal of Preventive Medicine found overprescription of opioids by dentists common, particularly to patients at high risk for substance abuse, and that almost 1/3 of patients received more powerful drugs than neededElsevierIMAGE: In this cross-sectional analysis of 542,958 dental visits by adult patients, between 1 in 4 and 1 in 2 opioid prescriptions exceeded the recommended morphine equivalents and days'supply for...viewmore Credit: Michelle S. Woods Ann Arbor, February 4, 2020 - Dentists are among top prescribers of opioids in the US, however, whether their opioid prescrib...
Source: Dental Technology Blog - February 13, 2020 Category: Dentistry Source Type: news

'Painkillers should be renamed pain relievers to prevent people from taking a higher dose'
Medical experts argue that misconception that pain will be completely 'killed' makes people believe they should increase their dose. This is helping drive Britain's overuse of opioids such as morphine. (Source: the Mail online | Health)
Source: the Mail online | Health - February 6, 2020 Category: Consumer Health News Source Type: news

Duramorph (Morphine Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 5, 2020 Category: Drugs & Pharmacology Source Type: news

Re-engineered plant compound treats opioid addiction in mice
(American Chemical Society) The abuse of prescription and illegal opioids, such as morphine and heroin, is a major problem in the US, with devastating public health, economic and social consequences. That's why scientists are searching for new medicines to help break the cycle of addiction. Now, researchers reporting in ACS' Journal of Medicinal Chemistry have re-engineered the structure of vincamine, a plant-derived compound, so that it reduces morphine-seeking behaviors in mice.   (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 5, 2020 Category: International Medicine & Public Health Source Type: news

German nurse in morphine babies case freed after test mix-up
Prosecutors say a nurse at a German hospital who was arrested on suspicion of administering morphine to five young babies has been released after new tests showed that investigators' initial findings were wrong (Source: ABC News: Health)
Source: ABC News: Health - February 4, 2020 Category: Consumer Health News Tags: Health Source Type: news

Nurse in Germany Charged With Attempted Killing of Five Babies Nurse in Germany Charged With Attempted Killing of Five Babies
Authorities in southwestern Germany detained an intensive care nurse on Wednesday, suspecting that she had attempted to kill five newborn babies in her charge with morphine, police in the city of Ulm said.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 1, 2020 Category: Intensive Care Tags: Pediatrics News Source Type: news

Abuse-deterrent formulation of morphine saves healthcare costs
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2020 Category: Drugs & Pharmacology Source Type: news

Germany: nurse suspected of drugging 5 babies with morphine
Officials say a nurse at a German hospital has been arrested on suspicion that she administered morphine to five young babies shortly before Christmas (Source: ABC News: Health)
Source: ABC News: Health - January 30, 2020 Category: Consumer Health News Tags: Health Source Type: news

More Concern Over Morphine, Clopidogrel Interaction in ACS More Concern Over Morphine, Clopidogrel Interaction in ACS
New data suggest use of morphine delays the absorption of clopidogrel and leads to an increase in short-term cardiac ischemic events.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - January 23, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Former ER Nurse Sentenced to 60 Months in Prison for Fraudulently Obtaining, Tampering with Patient Drugs
Elet Neilson, Layton UT, emergency room, ER, nurse, tampering, personal use, diversion, infect Hep C, McKay-Dee Hospital, Ogden UT, hydromorphone, morphine, intravenous opioid, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - January 14, 2020 Category: Medical Law Authors: DOJ Source Type: news

Fentanyl deaths on rise in UK, drug report warns
The painkiller is said to be up to 100 times stronger than morphine and is entering UK markets. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 4, 2020 Category: Consumer Health News Source Type: news

Rwanda avoids US-style opioids crisis by making own morphine
Rwanda doesn't have access to costly opioids from big pharmaceutical companies, so the African country has come up with a solution (Source: ABC News: Health)
Source: ABC News: Health - December 28, 2019 Category: Consumer Health News Tags: Health Source Type: news

Sustained-Release Morphine Safe in Chronic Breathlessness Sustained-Release Morphine Safe in Chronic Breathlessness
Regular low-dose sustained-release oral morphine appears to be a safe treatment for chronic breathlessness, according to findings from a randomized clinical trial.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 27, 2019 Category: Intensive Care Tags: Family Medicine/Primary Care News Source Type: news

Rwanda makes own morphine while U.S. awash with opioids
As thousands die from opioid addiction in America, millions deal with untreated pain in the world's poorest nations. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 27, 2019 Category: Consumer Health News Source Type: news

Rwanda avoids US-style opioids crisis by making own morphine
Rwanda doesn't have access to costly opioids from big pharmaceutical companies, so the African country has come up with a solution (Source: ABC News: Health)
Source: ABC News: Health - December 25, 2019 Category: Consumer Health News Tags: Health Source Type: news

Haverhill Woman Sentenced for Drug Tampering
Lauren Perrin, Practical Nurse, Haverhill MA, Drug Tampering, Guilty Plea, Schedule II Controlled Substance, Morphine, Pain Relief, Hospice Patient, Maplewood Care and Rehabilitation Center, Amesbury MA, lowered potency (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - December 19, 2019 Category: Medical Law Authors: DOJ Source Type: news

Pharmacist Admits Tampering with Infusion Narcotics
Carl Mancini, Wolcott CT, Guilty Plea, Tampering, Pharmacist, Home Intravenous Infusions, Hospice Care Intravenous Infusions, Intravenous Infusions, Pain Management, Formulating Infusions, Workplace, Vials, Hydromorphone Hydrochloride, Morphine Sulfate Pentahydrate, Syringe, Saline, Crimping, Reseal (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - December 17, 2019 Category: Medical Law Authors: DOJ Source Type: news

Chronic opioid treatment may raise risk of post-traumatic stress disorder, study finds
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD.In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks. After the morphine wore off, the mice were given mild electric foot shocks. These mice showed a substantially longer “freezing response” than a second, control group of 24 mice t...
Source: UCLA Newsroom: Health Sciences - December 3, 2019 Category: Universities & Medical Training Source Type: news

Chronic opioid treatment may increase PTSD risk
(Springer) Long-term (chronic) treatment with opioids, such as morphine, prior to trauma enhances fear learning in mice, according to a study published in Neuropsychopharmacology. The findings, which link chronic opioid treatment before a traumatic event with responses to subsequent stressful events, may suggest a possible mechanism underlying the frequent co-occurrence of post-traumatic stress disorder (PTSD) and opioid dependence. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2019 Category: International Medicine & Public Health Source Type: news

Fighting opioids with an unlikely supplemental painkiller: Anti-itch medicine
(West Virginia University) West Virginia University researcher Shane Kaski is investigating whether an anti-itch medication that targets a specific part of our nerve cells can make morphine -- which targets a different part--more effective. His findings suggest it can. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 21, 2019 Category: International Medicine & Public Health Source Type: news

News: No Reason to Choose Tramadol over Morphine
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - November 1, 2019 Category: Emergency Medicine Tags: News Source Type: news

How the Ban on Medical Advertising Hurt Women Doctors
This article was published on JSTOR Daily, read the original article here. (Source: TIME: Health)
Source: TIME: Health - October 16, 2019 Category: Consumer Health News Authors: Olivia Campbell / JSTOR Daily Tags: Uncategorized health medicine onetime syndication Source Type: news

Registered Nurse Indicted on Drug Diversion Charge
Brianna Duffy, Haverhill MA, Hunt Nursing and Rehab, Danvers MA, morphine sulfate, hospice, patient, Maplewood Care and Rehabilitation Center, Amesbury MA, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 11, 2019 Category: Medical Law Authors: DOJ Source Type: news

Former Dracut Nurse Pleads Guilty to Tampering with Liquid Morphine
Michael Langlois, registered nurse, elderly hospice patients, Lowell MA nursing home, saline, Benadryl, Melrose MA nursing home, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 7, 2019 Category: Medical Law Authors: DOJ Source Type: news

Researchers Develop New Opioid Detection Breath Test
(CBS) – Breathalyzer tests have been around for years to help identify drunk drivers, but soon there could soon be a similar test for opioids. Engineers and physicians at the University of California, Davis have developed a test that can detect opioids in the exhaled breath of patients taking pain medications like morphine and oxycodone. They hope to eventually have a real time test which could help doctors and nurses determine whether patients with chronic pain are taking their medications properly, and also to check for illegal drug use. The team is also working on similar breath-based tests that could screen ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 7, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated Local Confronting The Crisis opioids Source Type: news

New Breath Test Detects Opioid Use
Researchers at the University of California, Davis have developed an interesting way to combat the opioid crisis. The group, comprised of engineers and physicians, have developed a test that can detect opioid drugs in exhaled breath. "There are a few ways we think this could impact society," Professor Cristina Davis, chair of the Department of Mechanical and Aerospace Engineering at UC Davis, who led the research along with Professor Michael Schivo from the UC Davis Medical Center, said in a release. The work is described in a paper published in the Journal of Breath Research Oct. 3. Doctors and nurses treating c...
Source: MDDI - October 5, 2019 Category: Medical Devices Authors: MDDI Staff Tags: IVD Source Type: news

Haverhill Nurse Pleads Guilty to Drug Tampering
Lauren Perrin, morphine, licensed practical nurse, LPN, Maplewood Care and Rehabilitation Center, Amesbury MA, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - October 4, 2019 Category: Medical Law Authors: DOJ Source Type: news

10 people in one Ohio county fatally overdose on drugs likely laced with fentanyl in just 26 HOURS
10 unnamed people in Franklin County, Ohio, overdosed over 26 hours, according to the Coroner's Office. It may be linked to fentanyl, the synthetic opioids 100 times stronger than morphine. (Source: the Mail online | Health)
Source: the Mail online | Health - September 30, 2019 Category: Consumer Health News Source Type: news

Genetic behavioral screen identifies an orphan anti-opioid system
Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management, but their addictive properties can lead to severe abuse. We developed a whole-animal behavioral platform for unbiased discovery of genes influencing opioid responsiveness. Using forward genetics in Caenorhabditis elegans, we identified a conserved orphan receptor, GPR139, with anti-opioid activity. GPR139 is coexpressed with MOR in opioid-sensitive brain circuits, binds to MOR, and inhibits signaling to heterotrimeric guanine nucleotide–binding proteins (G proteins). Deletion of GPR139 in mice enhanced opioid-induced inhibition of neu...
Source: ScienceNOW - September 19, 2019 Category: Science Authors: Wang, D., Stoveken, H. M., Zucca, S., Dao, M., Orlandi, C., Song, C., Masuho, I., Johnston, C., Opperman, K. J., Giles, A. C., Gill, M. S., Lundquist, E. A., Grill, B., Martemyanov, K. A. Tags: Cell Biology, Neuroscience r-articles Source Type: news

Prevention of Nausea, Vomiting After Abdominal Hysterectomy Prevention of Nausea, Vomiting After Abdominal Hysterectomy
Postoperative nausea and vomiting is common with intrathecal morphine use in total abdominal hysterectomy. Which antiemetic is most effective for these patients?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 18, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Dishing out more drugs won ’t stop the pain. Doctors need new tools | Ann Robinson
As a GP, I know opioids have their place. But we shouldn ’t be complacent about a US-style crisis happening in BritainGrowing concern about the prescription of drugs that cause dependence has been backed up by a recent report from Public Health England (PHE). The agencydiscovered that in 2017-18, 13% of adults in England received at least one prescription for opioids such as morphine or oxycodone (although this represented a slight downturn in prescribing after a long upward trend). Other drug classes were implicated too, with 25% of adults prescribed one or more of the following drugs: benzodiazepines (such as Valiu...
Source: Guardian Unlimited Science - September 15, 2019 Category: Science Authors: Ann Robinson Tags: Opioids GPs NHS Doctors Health Society Drugs policy Politics Science UK news Source Type: news

Rx Size Predicts Persistent Opioid Use After Cardiothoracic Surgery
Patients prescribed more than 450 oral morphine equivalents have more new persistent opioid use (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - August 22, 2019 Category: Respiratory Medicine Tags: Cardiology, Pharmacy, Pulmonology, Surgery, Anesthesiology & amp; Pain, Geriatrics, Journal, Source Type: news

Opioid-free Anesthesia and Post-op Period in Cardiac Surgery Opioid-free Anesthesia and Post-op Period in Cardiac Surgery
What impact might an opioid-free anesthesia protocol in cardiac surgery have on post-operative morphine consumption, ICU stay, and outcome?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 16, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Vital signs: Pharmacy-based naloxone dispensing - United States, 2012-2018 - Guy GP, Haegerich TM, Evans ME, Losby JL, Young R, Jones CM.
BACKGROUND: The CDC Guideline for Prescribing Opioids for Chronic Pain recommends considering prescribing naloxone when factors that increase risk for overdose are present (e.g., history of overdose or substance use disorder, opioid dosages ≥50 morphine ... (Source: SafetyLit)
Source: SafetyLit - August 10, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Intranasal Sufentanil Effective for Acute Severe Trauma Pain Intranasal Sufentanil Effective for Acute Severe Trauma Pain
Intranasal sufentanil is as effective as intravenous morphine for treating acute severe trauma pain, according to results from a noninferiority study.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - July 17, 2019 Category: Surgery Tags: Anesthesiology News Source Type: news

Intranasal Sufentanil Cuts Acute Trauma Pain Treated in the ED
WEDNESDAY, July 17, 2019 -- Intranasal sufentanil (INS) is comparable to intravenous morphine (IVM) for acute severe trauma pain treated in the emergency department, according to a study published online July 16 in PLOS Medicine. Marc Blancher,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 17, 2019 Category: Pharmaceuticals Source Type: news