Latest Phase 3 Data for First-in-Class TREMFYA ® (guselkumab) Demonstrates Significant and Durable Improvement in Signs and Symptoms of Active Psoriatic Arthritis while Maintaining its Safety Profile in Patients with Inadequate Response to Tumor Necrosis Factor Inhibition (TNFi-IR)

SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus placebo at week 24 in this documented TNFi-IRa patient population, which is often more difficult to treat.1 Furthermore, improvements in signs and symptoms of PsA were maintained or numerically increased through one year (week 48) among TREMFYA-randomized patients.1“Active psoriatic arthritis is a heterogenous disease and a significant number of patients do not respond adequately to TNF inhibition,” said lead author Laura Coates, M.D., Ph.D., Associate Professor, University of Oxford, UK.b “The COSMOS data demonstrate that TREMFYA significantly improved signs and symptoms of active psoriatic arthritis across multiple clinical disease domains, including patient reported outcomes, with treatment effects observed by week four. These findings reinforce the utility of this alternative mechanism of action as a therapeutic option for adults with a...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news

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... persistent on multiple attempts Thanks!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Today a couple of therapists were talking about what they would do if they were fired for not being vaccinated. Despite the mandate being held up by the supreme court, they still aren't going to get it. Our leadership hasn't issued any plans yet. I was just curious what other departments/groups are doing about it. Hopefully without the thread devolving into a political dumpster fire discussion. People being fired? Testing weekly?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
In 2020, the property was selected to be the site of a large facility meant to produce injection devices for the mass delivery of vaccines. But that project remains in limbo.
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsRegardless of a patient ’s baseline symptom severity, CBT and ADM-c both prevent depressive relapse substantially better than medication discontinuation. Given the shorter duration of treatment and equivalent longer-term outcomes, treatment with CBT might be considered a first choice for adults with depression.
Source: Cognitive Therapy and Research - Category: Psychiatry & Psychology Source Type: research
European Journal of Human Genetics, Published online: 15 January 2022; doi:10.1038/s41431-021-01017-2Where is genetic medicine headed? Exploring the perspectives of Canadian genetic professionals on future trends using the Delphi method
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractA recent article entitled “Full‑endoscopic (bi‑portal or uni‑portal) versus microscopic lumbar decompression laminectomy in patients with spinal stenosis: systematic review and meta‑analysis” written by Pairuchvej et al. (Eur J Orthop Surg Traumatol 30(4):595–611, 2019) published in “European Journal of Ortho paedic Surgery&Traumatology ” has aroused our great interest. The authors concluded that compared with minimally invasive decompression surgery, full endoscopic spinal surgery had better pain relief (back pain and leg pain) in the treatment of lumbar spinal stenosis an...
Source: European Journal of Orthopaedic Surgery and Traumatology - Category: Orthopaedics Source Type: research
ConclusionThe pooled mean difference indicates improvement in HRQoL after cholecystectomy but with high heterogeneity. Further high-quality studies from Asian countries are required for globally representative quantification and precise estimates of HRQoL among gallstone diseases.PROSPERO Registration ID.CRD42021234467.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionCusp bending was the most frequent etiology of AR in the elderly. Preoperative detection of cusp bending by TEE would expand the therapeutic strategy for AR, including aortic valvuloplasty.
Source: Journal of Medical Ultrasonics - Category: Radiology Source Type: research
The objective of this study is to evaluate the life course effects of racism on depressive symptoms in young Black women and to identify particularly sensitive periods. Guided by life-course theory and using logistic regression, we analyzed baseline data on racism frequency and stress from racism at two time periods (before age 20 and during the 20s) and follow-up data (at approximate 20-month intervals) on depressive symptoms (using a modified 11-item Center for Epidemiologic Studies Depression Scale, CES-D) among 1612 Black women participants aged 23 –34 years living in Detroit, MI. Of the 1612 women, 65% repo...
Source: Journal of Urban Health - Category: Health Management Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
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