Study Backs Recommended Antibiotic Approach for Aspiration Pneumonia
(MedPage Today) -- Antibiotic therapy with extended anaerobic coverage (EAC) was not associated with a survival benefit in patients with community-acquired aspiration pneumonia, according to results from a retrospective cohort study that support... (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - February 21, 2024 Category: Infectious Diseases Source Type: news

Oral Switch Noninferior for Low-Risk S. Aureus Bloodstream Infection
FRIDAY, Jan. 26, 2024 -- For patients with low-risk Staphylococcus aureus (S. aureus) bloodstream infection, early switch to oral antimicrobial therapy is noninferior to intravenous standard therapy, according to a study published online Jan. 17 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 26, 2024 Category: Pharmaceuticals Source Type: news

6 Stories Show the Human Toll of Poland ’ s Strict Abortion Laws
This project was supported by the Pulitzer Center [time-brightcove not-tgx=”true”] Krzysztof Sowinski has cried every day since his wife Marta, who was five months pregnant, died of sepsis in 2022; he believes doctors put Marta’s life in danger by not giving them the option to terminate the pregnancy while the fetus’ heart was still beating. Janusz Kucharski also lost his partner Justyna to sepsis in the fifth month of a pregnancy. She left behind two boys. It is likely, reproductive-rights advocates say, that these women would be alive if not for Poland’s increasingly restrictive abort...
Source: TIME: Health - October 13, 2023 Category: Consumer Health News Authors: Anna Pamula Tags: Uncategorized abortion Source Type: news

Effect of subgingival periodontal therapy on glycaemic control in type 2 diabetes patients: Meta-analysis and meta-regression of 6-month follow-up randomized clinical trials
Discussion: None of the 12 studies were assessed as having low risk of bias. The percentage of females and the time of diabetes diagnosis significantly explained the high level of heterogeneity. Subgingival periodontal therapy results in a significant and clinically relevant improvement in glycaemic control over 6 months in patients with T2DM and periodontitis. The grade of evidence was moderate.  (Source: Dental Technology Blog)
Source: Dental Technology Blog - June 19, 2023 Category: Dentistry Source Type: news

Sepsis and antibiotics: When should we deploy a parachute?
In sepsis and septic shock, guidelines recommend administering antimicrobial therapy within the first hour following diagnosis. This recommendation is based on observational studies suggesting that early antimicrobial therapy was associated with improved outcomes. Consequently, physicians working at the front line are under pressure to decide in a short time the need for antibiotics in patients in whom the diagnosis of sepsis remains uncertain. On the other hand, overuse of antibiotics is associated with emergence of multidrug resistant bacteria, which constitutes worldwide a major health issue. Physicians at the front lin...
Source: Current Awareness Service for Health (CASH) - March 14, 2023 Category: Consumer Health News Source Type: news

University of Washington Researchers Use Genomic Analysis to Track Shigella Infections as Decreased Cost of Gene Sequencing Aids Public Health Research
Another study in the United Kingdom that also used genomic analysis to understand drug-resistant Shigella produced findings that may be useful for microbiologists and medical laboratory scientists From the onset of an infectious disease outbreak, public health officials, microbiologists, and clinical laboratory managers find it valuable to trace the origin of the spread back to […] The post <strong>University of Washington Researchers Use Genomic Analysis to Track Shigella Infections as Decreased Cost of Gene Sequencing Aids Public Health Research</strong> appeared first on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - March 1, 2023 Category: Laboratory Medicine Authors: Jillia Schlingman Tags: International Laboratory News Laboratory Pathology Laboratory Testing Molecular Diagnostics, Genetic Testing, Whole Gene Sequencing anatomic pathology antimicrobial therapy CDC Center for Infectious Disease Research and Policy centers for Source Type: news

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians.
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated host response or response to treatment and/or aid clinicians to prognosticate patient risk. More than 250 biomarkers have been identified and evaluated over the last few decades, but no biomarker accurately differentiates between sepsis and sepsis-like syndrome. Published data support the use of biomarkers for pathogen identification, clinical diagnosis, and optimization of antibiotic treatment. In this narrative revi...
Source: Current Awareness Service for Health (CASH) - January 11, 2023 Category: Consumer Health News Source Type: news

Antimicrobial Therapy of CAP During Stewardship Efforts Antimicrobial Therapy of CAP During Stewardship Efforts
Guideline recommendations for the treatment of community acquired pneumonia reflect efforts to improve antibiotic stewardship, but are these guidelines being followed?BMC Pulmonary Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 15, 2022 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Current sepsis therapeutics
Management of the patient with sepsis comprises three key branches: control of the underlying infection, haemodynamic stabilization, and modulation of the host response. Each aspect should be considered in all patients and, when relevant, managed at the same time. Infection control is applicable to all patients with sepsis and will include antibiotic therapy and often surgical intervention to remove an infectious source. Haemodynamic support involves fluid administration in all patients and vasoactive agents in patients with associated circulatory shock. Noradrenaline is the first choice vasopressor agent; inotropic agents...
Source: Current Awareness Service for Health (CASH) - December 13, 2022 Category: Consumer Health News Source Type: news

Cost-minimisation analysis of oritavancin for the treatment of acute bacterial skin and skin structure infections from a United Kingdom perspective.
Conclusion: Oritavancin, used to support ED, is associated with lower costs compared with dalbavancin and reduced treatment duration relative to all comparators. Its use would support an ED approach in MRSA ABSSSI management. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 15, 2022 Category: Consumer Health News Source Type: news

Targeted Antibiotic Therapy Helpful for Sinusitis Management Targeted Antibiotic Therapy Helpful for Sinusitis Management
Empiric rhinosinusitis treatment is rife with antibiotic overuse. Are there ways to improve antibiotic stewardship for this common diagnosis?Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 2, 2022 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting.
In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and its association to mortality. Methods: A retrospective cohort study model was undertaken to outline BSI in an intensive care, single centre, and low antimicrobial resistance prevalence setting. We used descriptive statistics to delineate proportions of patients that received discordant empirical antimicrobial therapy, and a correlation model and a logistic regression model to calculate the association with mortality and predictors of receiving discordant therapy, respectively. Results: From 2014 to 2...
Source: Current Awareness Service for Health (CASH) - November 2, 2022 Category: Consumer Health News Source Type: news

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial.
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news