Rapid Test May Help Avoid Aminoglycoside-Induced Hearing Loss in Newborns Rapid Test May Help Avoid Aminoglycoside-Induced Hearing Loss in Newborns
Researchers have developed a rapid genetic point-of-care test to help guide antibiotic therapy and avoid aminoglycoside-induced ototoxicity in babies in the neonatal intensive care unit.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 22, 2022 Category: Pathology Tags: Pediatrics News Source Type: news

Treatment Strategy Studied for Drug Use-Linked Infective Endocarditis
MONDAY, March 14, 2022 -- A modeling study suggests that incorporating outpatient parenteral antimicrobial therapy (OPAT) or partial oral antibiotic approaches along with addiction care services in the treatment of patients with injection drug... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 14, 2022 Category: Pharmaceuticals Source Type: news

Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial.
Conclusions: Our findings suggest that management of sepsis is time critical both for antimicrobial therapy and source control. Also patients, who are not yet in septic shock, profit fro m early anti-infective treatment since it can prevent further deterioration. Trial registration ClinicalTrials.gov ( NCT01187134 ). Registered 23 August 2010, NCT01187134. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 10, 2022 Category: Consumer Health News Source Type: news

Take-home antibiotic therapies may improve health outcomes, lower costs, for patients with drug use-associated infective endocarditis
Often fatal, endocarditis remains a dangerous but largely unknown health threat for people who inject drugs. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 28, 2022 Category: American Health Source Type: news

Take-home antibiotic therapies may improve health outcomes, lower costs, for patients with drug use-associated infective endocarditis
Often fatal, endocarditis remains a dangerous but largely unknown health threat for people who inject drugs (Source: NIDA News)
Source: NIDA News - February 28, 2022 Category: Addiction Tags: News Release, Evidence-Based Practices, Harm Reduction, Treatment Source Type: news

Analysis of Missed Sepsis Patients in a Pediatric Emergency Department With a Vital Sign-Based Electronic Sepsis Alert
Conclusions: In an ED with an electronic sepsis alert, missed patients often had positive sepsis alerts but were not treated for sepsis. Missed patients were more likely than sepsis pathway patients to require escalation of care after admission and less likely to receive timely antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Risk for Early-Onset Sepsis Low for Infants With Low-Risk Delivery
WEDNESDAY, Jan. 26, 2022 -- Infants born at all gestational ages with low-risk delivery characteristics have a low risk for early-onset sepsis (EOS) and may not require initiation of empiric antibiotic therapy immediately following birth, according... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 26, 2022 Category: Pharmaceuticals Source Type: news

Gastrointestinal PCR Panel Enables Faster, Better Antibiotic Therapy in Kids With Infectious Diarrhea Gastrointestinal PCR Panel Enables Faster, Better Antibiotic Therapy in Kids With Infectious Diarrhea
Using a multiplex gastrointestinal PCR (GI-PCR) panel in children with infectious diarrhea can speed up appropriate prescription of antibiotics, a new study suggests.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - January 19, 2022 Category: Gastroenterology Tags: Pediatrics News Source Type: news

Sepsis Definitions: I Know It When I See It*
Over the past 3 –4 decades, efforts have been made to define sepsis, severe sepsis, and septic shock more objectively. For purposes of this editorial, “sepsis” will include the full spectrum of sepsis, severe sepsis, and septic shock. Why is sepsis so difficult to define? There are many signs, symptoms, and l aboratory abnormalities that commonly occur in patients with sepsis, but there is not a single “gold standard” definition or criterion that clinicians can all agree on and that facilitates the prompt recognition of the syndrome. The manifestations of sepsis are highly variable, and an infecting organism is n...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

Widening the net: a literature review of antimicrobial agents with potential suitability for outpatient parenteral antimicrobial therapy servicesthe importance of storage and stability
Review of 18 stability studies found aminopenicillins (e.g. ampicillin and amoxicillin) appear too unstable for continuous infusion (CI). Cephalosporins vary in their stability and CI periods of 24 hours may not be achievable, and meropenem is unsuitable for CI. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 7, 2021 Category: Consumer Health News Source Type: news

Timing of Antibiotic Therapy in the ICU Timing of Antibiotic Therapy in the ICU
Infections among ICU patients require timely and appropriate antibiotic therapy while also considering the risk of antibiotic resistance.Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 7, 2021 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Latest Phase 3 Data for First-in-Class TREMFYA ® (guselkumab) Demonstrates Significant and Durable Improvement in Signs and Symptoms of Active Psoriatic Arthritis while Maintaining its Safety Profile in Patients with Inadequate Response to Tumor Necrosis Factor Inhibition (TNFi-IR)
SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus placeb...
Source: Johnson and Johnson - December 3, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Potential impact of national recommendations to use short course antibiotic therapy on antibiotic use in the emergency department of a UK hospital: retrospective observational study
Study of 1215 days of antibiotic therapy in 365 patients in the emergency department found 16% of days were excess prescribing owing to inappropriate protracted prescribing. 79% of defined daily doses of antibiotics for treatment of upper RTI were classed as excess prescribing. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 16, 2021 Category: Consumer Health News Source Type: news

Impact of Pharmacist-Directed Simplified Procalcitonin Algorithm on Antibiotic Therapy in Critically Ill Patients With Sepsis
Conclusion: Use of a simplified PCT algorithm with pharmacist-guided recommendations significantly reduced the duration of antibiotic therapy in critically ill patients with sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 10, 2021 Category: Consumer Health News Source Type: news

Surgery Needed in Nearly Half of Appendicitis Patients Treated With Antibiotics Surgery Needed in Nearly Half of Appendicitis Patients Treated With Antibiotics
Antibiotic therapy can prevent or delay the need for an appendectomy, but ultimately nearly half of the patients will eventually require the surgery, according to the largest, long-term comparison of immediate surgery versus antibiotic treatment.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - October 27, 2021 Category: Surgery Tags: General Surgery News Source Type: news