A syndrome-based approach to antimicrobial stewardship in an Arizona skilled nursing facilityMoving the needle through quality improvement. American journal of infection control 48(12): 1537-1539
In 2015, an intervention to reduce unnecessary antibiotic prescribing for suspect urinary tract infection (UTI) was implemented in an Arizona skilled nursing facility. • Intervention included use of a 48[HYPHEN]hour enhanced observation protocol instead of urine culturing in low infection likelihood scenarios (eg, confusion without localizing signs of infection) and monthly feedback to providers on culturing and prescribing patterns. • In the 2 years following implementation of the intervention, antibiotic prescribing for suspect UTIs decreased by 85%, and C. difficile incidence by 86%, with no associated uroseps...
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

There is no association between weekend admissions and delays in antibiotic administration for patients admitted to the emergency department with suspicion of sepsis: A retrospective cohort study. Medicine 99(47): e23256.
This study was conducted to evaluate whether weekend admissions to the ED increases the time to antibiotic administration in septic patients.A retrospective cohort study of adult patients who were included in the sepsis protocol at a tertiary ED between January 2015 and December 2017 was performed. The sepsis protocol was activated for all patients with suspected severe infection.A total of 831 patients with a mean age of 59 ± 21 years were evaluated, of whom 217 (26.1%) were admitted on weekends. In addition, 391 (47.1%) patients were male, and 84 (10.1%) died in the hospital. Overall, the mean sequential organ fai...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Resistant Infections in Emergency Department Patients with Suspected Sepsis. The American journal of the medical sciences 360(6): 650-655.
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Empiric Antibiotic Prescribing for Suspected Sepsis: A Stewardship Balancing Act. The American journal of the medical sciences 360(6): 613-614.
The optimal approach to empiric antibiotic prescribing for suspected sepsis in the emergency department (ED), specifically timing and spectrum of therapy, is a matter of significant ongoing controversy.1 −3 The debate hinges on interpretation of the ratio between benefit from prompt, active antibiotic therapy for patients with bacterial sepsis and the established societal (e.g. selective pressure towards bacterial resistance) and patient level harms associated with unnecessary antibiotic therapy ( e.g. adverse drug reactions, Clostridiodes difficile infection). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Updates in Sepsis Resuscitation
Sepsis care has evolved significantly since the initial early goal-directed therapy (EGDT) trials. Early fluid resuscitation, source control, and antibiotic therapy remain cornerstones of care but overall understanding is more nuanced, particularly regarding fluid selection, vasopressors, and inotropic support. Timely nutrition therapy and ventilatory support tend to receive less attention but also are important. Recent research has explored immunomodulation, β-blockade, and vitamin supplementation. A renewed emphasis on early, aggressive resuscitation reaffirms the importance of emergency medicine providers knowledge...
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

Recent updates on antimicrobial therapy
(Bentham Science Publishers) This book provides updates on the most recent studies about anti-infective agents, their mechanism of action, the relevant molecular targets and their implication in the development of novel antibiotics that have properties similar to their corresponding compounds of natural origin. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 30, 2020 Category: Infectious Diseases Source Type: news

Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?
On initial presentation, differentiation between earlystage coronavirus disease 2019 COVID-19) and classical bacterial community-acquired pneumonia can be challenging. Furthermore, COVID-19 patients may develop a hyperinflammatory phase later in their disease process, which is particularly difficult to distinguish from a secondary bacterial infection. As a consequence, 72% of COVID-19 patients receive empirical antibiotic therapy during hospital stay. Antibiotic overuse undoubtedly leads to an exacerbation of another —slowly progressive—pandemic: antimicrobial resistance. Procalcitonin (PCT) has proven useful i...
Source: Current Awareness Service for Health (CASH) - November 18, 2020 Category: Consumer Health News Source Type: news

Antibiotic Therapy Before Age 2 May Affect Child Health
TUESDAY, Nov. 17, 2020 -- Exposure to antibiotics in the first two years of life is associated with an increased risk for several health conditions during childhood, according to a study published online Nov. 15 in the Mayo Clinic... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 17, 2020 Category: Pharmaceuticals Source Type: news

Coronavirus Disease 2019 Sepsis: A Nudge Toward Antibiotic Stewardship
COVID-19 is sepsis caused by SARS-CoV-2, a virus for which there is little in the way of antimicrobial therapy. Because it is sepsis, known tenets of sepsis care and organ support must be our guiding principles. Surprisingly, a key lesson that we must take from the war on this viral sepsis is that we must redouble our efforts to be stewards of antimicrobials and ensure that we have adequate means to control bacterial and fungal infection. Moreover, it is critical that high priority be given to randomized controlled trials that are testing drugs to treat SARS-CoV-2 and the ensuing sepsis. As we face subsequent waves of this...
Source: Current Awareness Service for Health (CASH) - November 13, 2020 Category: Consumer Health News Source Type: news

Infectious Disease PICC Approval Tied to Fewer Complications Infectious Disease PICC Approval Tied to Fewer Complications
When peripherally inserted central catheters (PICCs) are placed for antimicrobial therapy, infectious disease physician approval is associated with more appropriate device use and a lower risk of complications, a new study found.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - November 10, 2020 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis
Conclusion(s): Use of an IV push strategy may safely facilitate more rapid administration of beta-lactam antibiotics and may allow for better compliance with sepsis management guidelines. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Antibiotics in the first hour: is there new evidence?
International guidelines have recommended for many years to start antimicrobials as early as possible in sepsis and shock. This concept has been challenged by the controversial results of experimental studies and clinical cohorts and resulted in intense debate in the literature. This review aims to summarize the available knowledge on early antimicrobial therapy and to consider perspectives. Areas covered: First, after a research using MEDLINE, we reviewed the studies that advocated the implementation of early antimicrobial therapy. We then discussed the drawbacks of these studies. Finally, we suggested possible explanatio...
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Discontinuation of glycopeptides in patients with culture negative severe sepsis or septic shock: A propensity-matched retrospective cohort study
Implementation of antibiotic stewardship is difficult in patients with sepsis because of severity of disease. We evaluated the impact of glycopeptide discontinuation (GD) in patients with culture negative severe sepsis or septic shock who received glycopeptides as initial empiric antibiotic therapy at admission. We conducted a single center retrospective cohort study between January 2010 and March 2018. GD was defined as discontinuation of initial empiric glycopeptides on availability of culture results, revealing the absence of identified pathogens. In 92 included patients, the leading causes of sepsis were pneumonia (34....
Source: Current Awareness Service for Health (CASH) - July 1, 2020 Category: Consumer Health News Source Type: news

Duration of antibiotic therapy in critically ill patients: A randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers
Conclusion(s): Daily monitoring of CRP levels may allow early interruption of antibiotic therapy in a higher proportion of patients, without an effect on total antibiotic consumption. The clinical and microbiological relevance of this finding remains to be demonstrated. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 1, 2020 Category: Consumer Health News Source Type: news

Benefits of prolonged infusion of beta-lactam antibiotics in patients with sepsis: personal perspectives
INTRODUCTION: In the current era of relatively scarce antibiotic production and significant levels of antimicrobial resistance, optimization of pharmacokinetics and pharmacodynamics of antibiotic therapy is mandatory. Prolonged infusion of beta-lactam antibiotics in comparison to the intermittent infusion has the theoretical advantage of better patient outcomes. Apparently, conflicting data in the literature possibly underestimate the benefits of prolonged infusion of antibiotic treatment. AREAS COVERED: We provide our perspective on the subject based on our experience and by critically evaluating literature data. EXPERT O...
Source: Current Awareness Service for Health (CASH) - July 1, 2020 Category: Consumer Health News Source Type: news

Pharmacokinetic and pharmacodynamic considerations in antimicrobial therapy for sepsis
Introduction: Antimicrobial dose optimization for the treatment of sepsis remains challenging because of dynamic pharmacokinetic alterations and physiological/pathological responses of the host. Subtherapeutic plasma levels of antimicrobials are commonly observed in patients with sepsis, which potentially leads to both treatment failure and emergence of antimicrobial resistance. The knowledge of antimicrobial pharmacokinetics and pharmacodynamics is helpful in order to tailor antimicrobial dosing strategies. Areas covered: This narrative review summarizes pharmacokinetic alterations of antimicrobial agents and provides use...
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Prevalence ofAntibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use
Conclusions and Relevance: In this study, most patients with community-onset sepsis did not have resistant pathogens, yet broad-spectrum antibiotics were frequently administered. Both inadequate and unnecessarily broad empiric antibiotics were associated with higher mortality. These findings underscore the need for better tests to rapidly identify patients with resistant pathogens and for more judicious use of broad-spectrum antibiotics for empiric sepsis treatment. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Analysis to determine cost-effectiveness of procalcitonin-guided antibiotic use in adult patients with suspected bacterial infection and sepsis
Conclusion(s): Real-world implementation of PCT-guided antibiotic use may have improved patients'quality of life while decreasing hospital costs in MICU patients with undifferentiated sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Bacterial and fungal etiology of sepsis in children in the United States: Reconsidering empiric therapy
Conclusion(s): In this nationally representative administrative database, the most common identified pathogen was S. aureus in previously healthy and chronically ill children. In addition, a high proportion of children with sepsis and select chronic diseases had infections with methicillin-resistant S. aureus, fungal infections, Pseudomonas infections, and C. difficile. Clinicians caring for pediatric patients should consider coverage of these organisms when administering empiric antimicrobials for sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Reduced antibiotic exposure by serial physical examinations in term neonates at risk of early-onset sepsis
Background: Suspected early-onset sepsis (EOS) results in antibiotic treatment of a substantial number of neonates who are uninfected. We evaluated if an approach using serial physical examinations (SPEs) can reduce antibiotic exposure for suspected EOS in term neonates during the first 3 days of life, without affecting safety. Method(s): Within a quality-improvement framework, SPEs for 24-48 hours for neonates with suspected EOS was implemented in the neonatal intensive care unit, Stavanger, Norway. The proportion of neonates>=37 weeks gestation exposed to antibiotics, antibiotic therapy-days and the safety outcome tim...
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Long-lasting, low toxicity antimicrobial peptide fights 'superbug' lung infections
(University of Pittsburgh) Through serendipity, researchers considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections. The new antibiotic -- administered via the windpipe to target lung infections -- proved more effective than its experimental predecessor and traditional last-resort antibiotic therapies in fighting drug-resistant bacteria in laboratory cell cultures and mice. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 1, 2020 Category: Infectious Diseases Source Type: news

Antibiotic Prophylaxis in Open Fractures Antibiotic Prophylaxis in Open Fractures
Prophylactic antibiotic therapy plays a key role in the management of open fractures by reducing the risk of infection. Which regimens are most effective?Journal of the American Academy of Orthopaedic Surgeons (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 28, 2020 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news

The History of Biomarkers: How Far Have We Come?
Sepsis is one of the oldest and most elusive syndromes in medicine that is still incompletely understood. Biomarkers may help to transform sepsis from a physiologic syndrome to a group of distinct biochemical disorders. This will help to differentiate between systemic inflammation of infectious and noninfectious origin and aid therapeutic decision making, hence improve the prognosis for patients, guide antimicrobial therapy, and foster the development of novel adjunctive sepsis therapies. To reach this goal requires increased systematic investigation that includes twenty-first century scientific approaches and technologies...
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news

Increased Mortality Seen With Empirical Anti-MRSA Treatment for Pneumonia Increased Mortality Seen With Empirical Anti-MRSA Treatment for Pneumonia
Empirical anti-MRSA treatment is associated with an increased risk of 30-day mortality in patients hospitalized for pneumonia, compared with standard antibiotic therapy, according to a retrospective study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 22, 2020 Category: Pathology Tags: Pulmonary Medicine News Source Type: news

QOL Similar After Surgery, Antibiotics for Uncomplicated Appendicitis
FRIDAY, Feb. 21, 2020 -- For patients being treated for uncomplicated acute appendicitis, quality of life (QOL) is similar at seven years after appendectomy or antibiotic therapy, according to a study published online Feb. 19 in JAMA Surgery. Suvi... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 21, 2020 Category: Pharmaceuticals Source Type: news

Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia
US-based cohort study of 88,605 hospitalisations for pneumonia did not find a mortality benefit for treatment with empirical anti –methicillin-resistant S aureus (MRSA) therapy vs standard antibiotics for any group of patients examined, even those with risk factors for MRSA. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 20, 2020 Category: Consumer Health News Source Type: news

Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial
RCT (n=352) found no significant difference in the primary composite end point of mortality, persistent bacteremia, relapse, or treatment failure for addition of an antistaphylococcal β-lactam to standard antibiotic therapy (vancomycin or daptomycin) vs standard therapy alone. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 13, 2020 Category: Consumer Health News Source Type: news

Partnership Seeks to Address Gaps in Diagnosing Sepsis
Sepsis continues to be a serious threat to patients globally. Recent studies estimate that more than 30 million people are impacted worldwide every year and may be implicated in 6 million deaths,1 David Dolinger, VP Product Realisation at QuantuMDx Group Limited, told MD+DI. Infection and drug resistance contribute significantly to sepsis risks. In neonatal care alone, it is estimated that one million newborn deaths each year are associated with maternal infection, such as maternal sepsis,2 pointed out Dolinger. And three out of every ten deaths because of neonatal sepsis are thought to be caused by resistant p...
Source: MDDI - February 1, 2020 Category: Medical Devices Authors: Daphne Allen Tags: IVD Source Type: news

Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia.
Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news

Journal Highlights From the January and February Issues of JAMDA
Antibiograms, created by a facility ’s contracted microbiology laboratory, can help hospitals and nursing homes identify trends in antibiotic resistance and create protocols for empiric antimicrobial therapy. In a recent study conducted in Providence, RI, Maria-Stephanie A. Hughes, PharmD, a fellow at the Providence Veterans Affairs Medical Center, and colleagues found a lack of agreement between antibiograms of Veterans Affairs (VA) nursing homes and their affiliated acute-care facilities. (Source: Caring for the Ages)
Source: Caring for the Ages - December 25, 2019 Category: Health Management Tags: Journal Highlights Source Type: news

Pleural Effusion: An Atypical Presentation of Kawasaki Disease Pleural Effusion: An Atypical Presentation of Kawasaki Disease
This case of a 7-year-old patient highlights the need to consider the diagnosis of Kawasaki disease in the presence of pneumonia and pleural effusion that is nonresponsive to antibiotic therapy.Journal of Medical Case Reports (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 24, 2019 Category: Intensive Care Tags: Family Medicine/Primary Care Journal Article Source Type: news

Antimicrobial prescribing: ceftolozane with tazobactam for treating hospital-acquired pneumonia, including ventilator-associated pneumonia
The manufacturer of ceftolozane with tazobactam anticipates that it will be used in line with good antimicrobial stewardship, on the advice of a microbiologist, to treat critically ill ventilated adults with HAP and VAP, who are deteriorating or not responding to initial antibiotic therapy, and who have confirmed or highly suspected Pseudomonas aeruginosa. Specialists involved in producing this evidence summary consider that ceftolozane with tazobactam provides a potentially useful alternative for treating some adults with HAP and VAP who have limited treatment options because they have infections suspected or proven to be...
Source: Current Awareness Service for Health (CASH) - December 19, 2019 Category: Consumer Health News Source Type: news

Ruth Bader Ginsburg Released From Hospital After Health Scare
The 86-year-old was first evaluated on Friday at a hospital in Washington, D.C., after feeling unwell. She was then transferred to The Johns Hopkins Hospital in Baltimore. By Saturday, her fever and chills had lessened after receiving intravenous antibiotic therapy and fluids, the spokeswoman said. (Source: WebMD Health)
Source: WebMD Health - November 25, 2019 Category: Consumer Health News Source Type: news

Every 15 Minutes, Someone In The US Dies Of A Drug-Resistant Superbug
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention. That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report. The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance. Genetic research shows germs have become especially adep...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Featured Health Antibiotics Bacteria CNN Superbugs Source Type: news

Antibiotic-Resistant ‘ Superbugs ’ A Growing Health Crisis, New Report Finds
By Elizabeth Cohen and Nadia Kounang, CNN (CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention. That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report. The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance. Gene...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston Antibiotics CNN Source Type: news

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin–specific TH17 cells imprinted in the intestine by a commensal Bacteroides species peptide mimic. Both the successful prevention of lethal disease in mice by antibiotic therapy and the significantly elevated Bac...
Source: ScienceNOW - November 13, 2019 Category: Science Authors: Gil-Cruz, C., Perez-Shibayama, C., De Martin, A., Ronchi, F., van der Borght, K., Niederer, R., Onder, L., Lütge, M., Novkovic, M., Nindl, V., Ramos, G., Arnoldini, M., Slack, E. M. C., Boivin-Jahns, V., Jahns, R., Wyss, M., Mooser, C., Lambrecht, Tags: Immunology, Medicine, Diseases reports Source Type: news

Oral Vancomycin Prevents C Diff Infection in High-Risk Inpatients Oral Vancomycin Prevents C Diff Infection in High-Risk Inpatients
Oral vancomycin prophylaxis can prevent healthcare-facility-onset C. difficile infection (HCFO-CDI) in high-risk patients receiving systemic antibiotic therapy, according to results from an open-label randomized study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 31, 2019 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity. We wanted to determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis. Among patients with severe manifestations of sepsis, initiation of empirical antimicrobial therapy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news

Procalcitonin and MR-proAdrenomedullin combination in the etiological diagnosis and prognosis of sepsis and septic shock
Procalcitonin and Mid-regional pro Adrenomedullin have been proposed for sepsis diagnosis, antibiotic therapy guidance and prognosis. . A retrospective analysis of PCT and MR-proADM on 571 consecutive patients with sepsis diagnosis was performed. PCT and MR-proADM combination represents an advantage for sepsis diagnosis and for 90-days mortality risk stratification. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news

Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study
Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity. We looked to determine the sensitivity of blood cultures obtained shortly after initiation of antimicrobial therapy in patients with severe manifestations of sepsis. Among patients with severe manifestations of sepsis, initiation of empirical antimicrobial therapy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis
Use of the neonatal EOS calculator is associated with a substantial reduction in the use of empirical antibiotics for suspected EOS. Available evidence regarding safety of the use of the EOS calculator is limited, but shows no indication of inferiority compared with conventional management strategies. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news

Antibiotic treatment for spontaneous bacterial peritonitis in people with decompensated liver cirrhosis: a network metaanalysis
This review (12 trials, n=1278; 13 antibiotics) found short ‐term mortality after spontaneous bacterial peritonitis (SBP) is approx. 25%. However, authors report significant uncertainty about which antibiotic therapy is better in people with SBP. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 25, 2019 Category: Consumer Health News Source Type: news

Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity
12 percent difference seen in proportion of positive blood cultures before and after antimicrobial therapy (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 17, 2019 Category: Cancer & Oncology Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Oncology, Pathology, Pharmacy, Journal, Source Type: news

Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity
TUESDAY, Sept. 17, 2019 -- When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced, according to a study published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2019 Category: Pharmaceuticals Source Type: news

Can Antibiotic Therapy for Cancer Improve Treatment Response to Immune Checkpoint Inhibitors?
A new study looked at median overall survival for patients with prior antibiotic therapy compared with patients with no prior antibiotic therapy. (Source: CancerNetwork)
Source: CancerNetwork - September 16, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Sepsis in 2018: a review
This article provides a summary of the most recent clinical evidence and professional guidelines for the diagnosis and treatment of the sepsis in the critical care setting. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news

Challenges and opportunities for antibiotic stewardship among preterm infants
Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the emergence of resistance species and protect patients from the side effects of unnecessary medication. The high incidence of systemic infection and associated mortality from these infections leads neonatal providers to frequently initiate antibiotic therapy and make empiric antibiotic courses one of the main contributors of antibiotic use in the neonatal units. Yet, premature infants are also at risk for acute life-threatening complications associated with antibiotic use such as necrotising enterocolitis and for long-term morbidities such as ...
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news

Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT
RCT (n=1054) found oral antibiotic therapy non-inferior to IV therapy when used during first 6 weeks in treatment for bone/joint infection, as assessed by definitive treatment failure within 1 year of randomisation (14.62% IV vs 13.16% oral), challenging current standard of care (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 27, 2019 Category: Consumer Health News Source Type: news

Antibiotic therapy for chronic infection with Burkholderia cepacia complex in people with cystic fibrosis
Review located one suitable RCT (n=100) which found that inhaled aztreonam lysine did not improve FEV1 and time to next exacerbation vs placebo. Authors therefore conclude that there is insufficient evidence to determine an effective antibiotic strategy for this infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 8, 2019 Category: Consumer Health News Source Type: news

Practical Tips for Diagnosing and Treating Bacterial Pneumonia in the Nursing Home
A clinical diagnosis of bacterial pneumonia in nursing home residents most often can be treated with a single oral course of antibiotic therapy targeted toward community-acquired pneumonia pathogens, Ghinwa Dumyati, MD, said at the AMDA — The Society for Post-Acute and Long-Term Care Medicine’s annual conference. (Source: Caring for the Ages)
Source: Caring for the Ages - July 30, 2019 Category: Health Management Authors: Christine Kilgore Source Type: news