Cost-minimisation analysis of oritavancin for the treatment of acute bacterial skin and skin structure infections from a United Kingdom perspective.
Conclusion: Oritavancin, used to support ED, is associated with lower costs compared with dalbavancin and reduced treatment duration relative to all comparators. Its use would support an ED approach in MRSA ABSSSI management. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 15, 2022 Category: Consumer Health News Source Type: news

Targeted Antibiotic Therapy Helpful for Sinusitis Management Targeted Antibiotic Therapy Helpful for Sinusitis Management
Empiric rhinosinusitis treatment is rife with antibiotic overuse. Are there ways to improve antibiotic stewardship for this common diagnosis?Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 2, 2022 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting.
In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and its association to mortality. Methods: A retrospective cohort study model was undertaken to outline BSI in an intensive care, single centre, and low antimicrobial resistance prevalence setting. We used descriptive statistics to delineate proportions of patients that received discordant empirical antimicrobial therapy, and a correlation model and a logistic regression model to calculate the association with mortality and predictors of receiving discordant therapy, respectively. Results: From 2014 to 2...
Source: Current Awareness Service for Health (CASH) - November 2, 2022 Category: Consumer Health News Source Type: news

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial.
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news

Evaluation of droplet digital PCR rapid detection method and precise diagnosis and treatment for suspected sepsis (PROGRESS): a study protocol for a multi-center pragmatic randomized controlled trial
In this study, a total of 2292 patients with suspected sepsis will be randomly assigned to two arms: the ddPCR group and the control group with a ratio of 3:1. The primary outcome is the diagnostic efficacy, that is, the sensitivity and specificity of the ddPCR assay compared with the synchronous blood culture. Secondary outcomes include the mortality rates and the mean Sequential Organ Failure Assessment (SOFA) score at follow-up time points, the length of stay in the hospital, the time to directed antimicrobial therapy, duration of broad-spectrum antibiotic use, and the EQ-5D-5L score on day 90. Discussion: It is the fir...
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news

Short-Course or Extended Antibiotics in Febrile Neutropenia? Short-Course or Extended Antibiotics in Febrile Neutropenia?
Short-course carbapenem antibiotic therapy is effective for chemotherapy-induced unexplained febrile neutropenia, although only for patients whose fever resolves after 3 days, say Dutch researchers.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 26, 2022 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

German Researchers Create Non-invasive Lab-on-a-Chip Biosensor That Detects Antibiotic Levels from Breath Samples
Should the device prove effective, it could replace invasive point-of-care blood draws for clinical laboratory testing during patient drug therapy monitoring What if it were possible to perform therapeutic drug monitoring (TDM) without invasive blood draws using breath alone? Patients fighting infections in hospitals certainly would benefit. Traditional TDM can be a painful process for […] The post German Researchers Create Non-invasive Lab-on-a-Chip Biosensor That Detects Antibiotic Levels from Breath Samples appeared first on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - June 22, 2022 Category: Laboratory Medicine Authors: Jillia Schlingman Tags: International Laboratory News Laboratory Instruments & Laboratory Equipment Laboratory Pathology Laboratory Testing Advanced Materials anatomic pathology antibiotic levels antibiotic resistance antibiotic therapy biosensor Can Dincer P Source Type: news

Novel Antibiotic Shows Promise for C diff Infection Novel Antibiotic Shows Promise for C diff Infection
A novel antibiotic therapy for Clostridioides difficile infection, currently dubbed CRS3123, has demonstrated narrower selectivity and reduced bacterial derangement in the gut compared with other antibiotics.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - May 6, 2022 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news

Rapid Test May Help Avoid Aminoglycoside-Induced Hearing Loss in Newborns Rapid Test May Help Avoid Aminoglycoside-Induced Hearing Loss in Newborns
Researchers have developed a rapid genetic point-of-care test to help guide antibiotic therapy and avoid aminoglycoside-induced ototoxicity in babies in the neonatal intensive care unit.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 22, 2022 Category: Pathology Tags: Pediatrics News Source Type: news

Treatment Strategy Studied for Drug Use-Linked Infective Endocarditis
MONDAY, March 14, 2022 -- A modeling study suggests that incorporating outpatient parenteral antimicrobial therapy (OPAT) or partial oral antibiotic approaches along with addiction care services in the treatment of patients with injection drug... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 14, 2022 Category: Pharmaceuticals Source Type: news

Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial.
Conclusions: Our findings suggest that management of sepsis is time critical both for antimicrobial therapy and source control. Also patients, who are not yet in septic shock, profit fro m early anti-infective treatment since it can prevent further deterioration. Trial registration ClinicalTrials.gov ( NCT01187134 ). Registered 23 August 2010, NCT01187134. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 10, 2022 Category: Consumer Health News Source Type: news

Take-home antibiotic therapies may improve health outcomes, lower costs, for patients with drug use-associated infective endocarditis
Often fatal, endocarditis remains a dangerous but largely unknown health threat for people who inject drugs. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 28, 2022 Category: American Health Source Type: news

Take-home antibiotic therapies may improve health outcomes, lower costs, for patients with drug use-associated infective endocarditis
Often fatal, endocarditis remains a dangerous but largely unknown health threat for people who inject drugs (Source: NIDA News)
Source: NIDA News - February 28, 2022 Category: Addiction Tags: News Release, Evidence-Based Practices, Harm Reduction, Treatment Source Type: news