A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration

The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the brain is to serve as the integrative center for anticipatory regulation, to orchestrate operations across systems, and thereby support behavioral optimality for successful interaction with the environment at large. Because ensuing usage of the term “allostasis” by other investigators has sometimes not recognized the full significance of the brain-centric and cross-system perspective first put forth by Sterling, this article refers to the paradigm of allostatic orchestration (PAO), to point toward his original ideas and to extend them. The essay reviews the origins and principles of homeostasis and allostasis and illustrates their differences by considering how they approach the phenomena of blood pressure regulation and posttraumatic stress disorder (PTSD). It contends that the Sterling principle of allostasis is sufficiently different that it w...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research

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This article attempts to aid clinicians in using diabetes devices in their clinical practice. It reviews device selection, initiation, and follow-up. It discusses work flow in an office and provides tips on billing. It stresses the need for patient choice, education, and on-going support through downloading and interpretation of data to optimize care. PMID: 31980122 [PubMed - in process]
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Endocrinol Metab Clin North Am Source Type: research
Authors: Fournier E Abstract Carpal tunnel syndrome (CTS) is too common a condition not to daily interact with the practitioner, if only because of its entanglement to other pathologies, causal or chance association. The typical symptomatology, with hand paresthesia and morning pain upon waking, is related to a median nerve injury in the confined space of the carpal tunnel, more often by local inflammation and tenosynovitis of the finger flexors (repetitive activity of the hands). SCC may be secondary to situations (pregnancy) or conditions (edema, hypothyroidism…), which exaggerate the ordinary pathophysiol...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Hosimin Selvaraj, Priyadharshini Aravind, Hema Sindhuja George, Maruthamuthu SundaramAbstractInvestigation and optimization of photoassisted electro-oxidation process for removal of high concentration of sulfide and COD from tannery lime wastewater was done. Electro oxidation process with UV-light were evaluated with different current densities such as 15, 20, 25 mA/cm2 with cylindrical electrodes (MMO and Ti sheet). 100% sulfide, 92% of COD and 70% total organic carbon (TOC) were effectively reduced by the curr...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Oneeb ul Haq, Da-Seul Choi, Jae-Hwan Choi, Youn-Sik LeeAbstractCapacitive deionization (CDI) has proved to be a clean and green technology; however, the charge leakage in the electrode pores during the adsorption-desorption cycles lowers the desalination efficiency. In this work, commercially available activated carbon was chemically treated to give the activated carbon surface either immobilized amino groups or sulfonic acid groups. The amino group-containing and sulfonic group-containing carbon materials were used ...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Kyeong Woo Chung, Ho-Sung Yoon, Chul-Joo Kim, Jin-Young Lee, Rajesh Kumar JyothiAbstractThe technology for extraction and recovery of the thorium from its source is one of the significant areas of research Present investigation deals on development of a process for extraction of thorium and its separation from the uranium and rare earths contained Korean monazite leach liquor. In the preliminary study, sulfuric acid treatment of monazite concentrate followed by water leaching was carried out. Furthermore double salt ...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
In conclusion, the prepared fly ash-based geopolymer provided favorable results for the removal of Basic Yellow 2 from aqueous solutions.Graphical abstract
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Malin Ly, Tizazu H. MekonnenAbstractCellulose nanocrystals (CNCs), a robust renewable and green nanomaterial, has potential as an excellent reinforcing and multifunctional filler for polymers used in coating and other applications. However, the high polarity of CNCs limits its interfacial interaction and dispersibility with several non-polar polymers. These limitations severely constrain it from transferring its functional attributes to polymeric materials. In this paper, three differentiated cationic surfactants: ce...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
In this study, sustainable fabrication method: 3D printing was utilized, and a bio-mimetically inspired a novel support composed of honeycombs that has full contact with the membrane surface and creates a shear web to enhance shear distribution in order to decrease fouling and reverse the solute flux of a forward osmosis system is introduced. The results showed that well-distributed shear highly reduced foulant adhesion on the membrane surface and reverse solute diffusion. As the orientations of hexagons also affect shear distribution, they were oriented both vertically and horizontally, and compared with the support of co...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Vaikundamoorthy Ramalingam, Inho HwangAbstractIn the present study, we investigated the effect of monodispersed zinc oxide (ZnO) nanoparticles on the proliferation, myogenic differentiation and regulation of associated myogenic marker genes. The as-prepared ZnO nanoparticles had the hexagonal wurtzite structure with maximum absorption at 355 nm and the band gap energy was found to be 3.21 eV. The electron microscopy analysis showed that the ZnO nanoparticles are spherical in shape with an average size range...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 25 January 2020Source: Aquatic ToxicologyAuthor(s): Christine Dépatie, Magali Houde, Jonathan VerreaultAbstractLipids play important roles in growth, reproduction, locomotion, and migration of fish. Municipal effluents, which are complex mixtures of biological and chemical compounds including flame retardants, have been shown to alter lipid metabletabolism in environmentally and experimentally exposed fish. Down-regulation of several genes coding for fatty acid metabolism enzymes has previously been reported in male northern pike (Esox lucius) collected in the St. Lawrence River (Q...
Source: Aquatic Toxicology - Category: Toxicology Source Type: research
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