The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence

Conclusions:
Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577

Received: 01 June 2016
Revised: 26 February 2017
Accepted: 27 February 2017
Published: 01 August 2017
Address correspondence to C.C. Kuo, Kidney Institute and Div. of Nephrology, Dept. of Internal Medicine, and Big Data Center, China Medical University Hospital and College of Medicine, China Medical University, 2 Yude Rd., North Dist., Taichung City 404, Taiwan. Telephone: [phone]-2913. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP577).
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research