Fight Aging! Newsletter, October 31st 2022
This study used mice to evaluate how their lifestyles - eating fatty foods vs. healthy and exercising vs. not - affected the metabolites of their offspring. Metabolites are substances made or used when the body breaks down food, drugs or chemicals, or its own fat or muscle tissue. "We have previously shown that maternal and paternal exercise improve health of offspring. Tissue and serum metabolites play a fundamental role in the health of an organism, but how parental exercise affects offspring tissue and serum metabolites has not yet been investigated."
Researchers used targeted metabolomics - the study of metabolites - to determine the impact of maternal exercise, paternal exercise, and the combination of maternal and paternal exercise on the metabolite profile in offspring liver, skeletal muscle, and blood serum levels. This study found that all forms of parental exercise improved whole-body glucose metabolism in offspring as adults, and metabolomics profiling of offspring serum, muscle, and liver reveal that parental exercise results in extensive effects across all classes of metabolites in all of these offspring tissues.
Towards Direct Reprogramming of Heart Fibroblasts into Cardiomyocytes
https://www.fightaging.org/archives/2022/10/towards-direct-reprogramming-of-heart-fibroblasts-into-cardiomyocytes/
A promising approach to inducing regeneration from injury and age-related fibrosis in the heart is the reprogramming of fibroblast cells into he...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
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