Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System

Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be divided into “indirect oral anticoagulants,” like vitamin K antagonists (VKAs; warfarin, or acenocoumarol), which have been the cornerstone of the anticoagulation therapy for decades, and into the more recently approved “direct oral anticoagulants” (DOACs), which are selective inhibitors of single coagulation factors. Belongs to DOACs the reversible direct thrombin inhibitor (dabigatran), and the direct factor Xa inhibitors (rivaroxaban, apixaban, and edoxaban) (Sabir et al., 2014; Monaco et al., 2017). Since their introduction, these more recent drugs have added some advantages to the clinical practice, like the rapid onset of action, the more predictable pharmacokinetics and pharmacodynamics, the potentially reduced risk for drug-drug interactions, and the absence of routine coagulation monitoring (Mekaj et al., 2015; Eikelboom and Me...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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According to a Gallup poll released in 2019, Americans are among the most stressed people in the world. We are connected to our smartphones 24/7, and we seldom take vacations. Can all this stress put you at risk for a stroke? Stress is also personal. Some people can handle high-stress situations, while others may not be able to function under stress. Dr. Andrew J. Ringer, chairman of Mayfield Brain and Spine, says there isn’t an easy answer to that question. “There are no studies that directly…
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Are patients with mental health conditions or lower socioeconomic status more likely to receive long-term opioid therapy?Pain
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
CONCLUSIONS Early detection of SB CD without complications remains difficult even if advanced modalities are introduced. Our hypothesis is that the fecal occult blood test and routine blood test should be administered to patients with abdominal pain or gastrointestinal manifestations. Once the patients are found to have GI bleeding or anemia, they would be further examined according to the guideline and SBCE would be used in the early stage of SB CD. PMID: 31738744 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Li YM, Jiang C, He L, Li XX, Hou XX, Chang SS, Lip GYH, Du X, Dong JZ, Ma CS Abstract BACKGROUND There is a growing recognition of sex-related disparities in atrial fibrillation (AF). However, limited data is available in Chinese AF patients. MATERIAL AND METHODS We compared symptoms, quality of life (QoL), and treatment of AF according to sex from the China AF Registry study. RESULTS We studied 14 723 patients with non-valvular AF, of whom 5645 patients (38.3%) were female. Women were older than men (67.5±10.6 vs. 62.2±12.2). Compared to men, women had more comorbidities and a higher proport...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS Our findings suggest that PLR is a useful parameter to consider when hematologists attempt to assess the risk of recurrence in ITP patients receiving first-line therapy, and the nonlinearity of PLR and ITP recurrence risk must be fully considered when constructing predictive models. PMID: 31735908 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Marques B, Couto J, Lemos MC, Rodrigues F Abstract Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 - 28 ng/dL), renin> 1000 mIU/mL (4.4 - 46.2 mIU/...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Authors: Sobrinho G, Ministro A, Silva A, Pedro L Abstract Renal artery aneurysms are rare. They are most commonly degenerative, congenital or due to medial fibroplasia. Proximal aneurysms can be repaired by endovascular and in-situ surgical techniques. However, aneurysms of the distal renal artery and its branches require ex-vivo surgical repair, also known as auto-transplantation: the kidney is removed, dissected and reconstructed in cold ischemia, and put back in place. A 69-year-old woman, with hypertension, presented with bilateral renal artery aneurysms with a diameter of 3.4 cm on the rig...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
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