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Poor NOAC Adherence in AF Wreaks Havoc on Efficacy vs Warfarin Poor NOAC Adherence in AF Wreaks Havoc on Efficacy vs Warfarin
Benefits of novel oral anticoagulants that wowed in clinical trials may not carry over into clinical practice, when adherence to prescribed therapy usually declines, suggests an observational analysis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 17, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

Low NOAC Adherence Worse Than Taking Warfarin?
(MedPage Today) -- Higher thromboembolic risk seen in observational data (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 14, 2018 Category: Cardiology Source Type: news

Five Things Surgeons Need to Know About NOACs to Minimize Risks Five Things Surgeons Need to Know About NOACs to Minimize Risks
Non-vitamin K oral anticoagulants (NOACs) differ in important ways from warfarin, and surgeons need to appreciate these differences, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 27, 2018 Category: Consumer Health News Tags: General Surgery News Source Type: news

Continuous Apixaban Safe During AF Ablation in At-Risk Patients Continuous Apixaban Safe During AF Ablation in At-Risk Patients
AXAFA-AFNEX 5 trial is the fourth to show similar safety with a novel oral anticoagulant vs warfarin, but some are disappointed with the new data.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 26, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

Apixaban is a safe alternative to warfarin during catheter ablation of atrial fibrillation
(European Society of Cardiology) Apixaban and warfarin are equally safe during catheter ablation of atrial fibrillation, according to results of the AXAFA-AFNET 5 trial presented today in a late-breaking trial session at EHRA 2018, a European Society of Cardiology (ESC) congress.1 There were similar rates of stroke and bleeding, and an improvement in cognitive function was shown for the first time. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 20, 2018 Category: International Medicine & Public Health Source Type: news

Evaluation of a protocol for early detection of delayed brain hemorrhage in head injured patients on warfarin - Huang JL, Woehrle TA, Conway P, McCarty CA, Eyer MM, Eyer SD.
PURPOSE: In 2007, Essentia Health St. Mary's Medical Center (SMMC), a Level II trauma center in northeastern Minnesota, implemented a protocol for patients who presented with blunt head trauma and were receiving warfarin for anticoagulation. The purpose of... (Source: SafetyLit)
Source: SafetyLit - March 19, 2018 Category: International Medicine & Public Health Tags: TBI Source Type: news

Head injury on Warfarin: likelihood of delayed intracranial bleeding in patients with negative initial head CT - Afaneh A, Ford J, Gharzeddine J, Mazar A, Hayward RD, Buck J.
OBJECTIVE: To determine the likelihood that head injured patients on Warfarin with a negative initial head CT will have a positive repeat head CT. A retrospective chart review of our institution's trauma registry was performed for all patients admitted for... (Source: SafetyLit)
Source: SafetyLit - March 19, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Comunicado de la FDA sobre la seguridad de los medicamentos: Estudio de la FDA de pacientes de Medicare encontr ó menor riesgo de derrame cerebral y muerte con Pradaxa (dabigatrán) en comparación con warfarina
[05-13-2014] En su estudio en curso del anticoagulante Pradaxa (dabigatr án), la Administración de Alimentos y Medicamentos de Estados Unidos (FDA por sus sigla en inglés) completó recientemente un nuevo estudio en pacientes de Medicare en el que compara Pradaxa con un anticoagulante antiguo, warfarina (Coumadin, Jantoven y genéricos), para determinar el riesgo de a ccidente isquémico o derrame causado por un coágulo, hemorragia cerebral, hemorragia gastrointestinal severa, infarto de miocardio y muerte. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 26, 2018 Category: Drugs & Pharmacology Source Type: news

FDA Drug Safety Communication: FDA study of Medicare patients finds risks lower for stroke and death but higher for gastrointestinal bleeding with Pradaxa (dabigatran) compared to warfarin
[05-13-2014] In its ongoing review of the blood thinner Pradaxa (dabigatran), the U.S. Food and Drug Administration (FDA) recently completed a new study in Medicare patients comparing Pradaxa to an older blood thinner, warfarin, for risk of ischemic or clot-related stroke, bleeding in the brain, major gastrointestinal (GI) bleeding, myocardial infarction (MI), and death. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 26, 2018 Category: Drugs & Pharmacology Source Type: news

Complications of lower extremity hematomas in patients with pre-injury warfarine use - Bukovcan P, Koller J.
INTRODUCTION: The aim of this paper is to ascertain the number of patients with pre-injury warfarin use who developed lower extremity hematomas treated in our facility, to analyse the data, used treatment methods and outcomes in these patients. PAT... (Source: SafetyLit)
Source: SafetyLit - February 19, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Lower ICH Mortality Rate With NOACs Than Warfarin Lower ICH Mortality Rate With NOACs Than Warfarin
A large real-world study provides some reassurance about the consequences of suffering an intracerebral hemorrhage when taking one of the new oral anticoagulants.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 13, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Intraocular Bleeding Risk Low With NOACs in Real-World Data (CME/CE)
(MedPage Today) -- Newer agents as safe as or safer than warfarin, other traditional agents (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - February 13, 2018 Category: Cardiology Source Type: news

FDA adds new information about warfarin INR test meters to FDA website to help patients, caregivers, and health care providers use these devices safely and effectively. https://go.usa.gov/xnHFk   #MedicalDevice
FDA adds new information about warfarin INR test meters to FDA website to help patients, caregivers, and health care providers use these devices safely and effectively. https://go.usa.gov/xnHFk  #MedicalDevice (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - February 12, 2018 Category: Medical Devices Authors: ( at FDADeviceInfo) Source Type: news

Warfarin Dosing in Cardiac Valve Replacement Warfarin Dosing in Cardiac Valve Replacement
This study identifies genetic polymorphisms which might be helpful for adjusting warfarin dosage to an effective and safe level in patients with cardiac valve replacement.Laboratory Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 12, 2018 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Coumadin vs. Plavix (Differences and Similarities)
Title: Coumadin vs. Plavix (Differences and Similarities)Category: MedicationsCreated: 2/1/2018 12:00:00 AMLast Editorial Review: 2/1/2018 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 1, 2018 Category: Cardiology Source Type: news

Dabigatran vs warfarin in NVAF: ERG risk score predicts cost
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2018 Category: Drugs & Pharmacology Source Type: news

ICH Survival Lower with Prior Anticoagulant Use
(MedPage Today) -- Still, risk lower with NOACS compared with warfarin (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 26, 2018 Category: Cardiology Source Type: news

Herbal Supplements May Be Dangerous When You Take Certain Prescription Drugs
A number of common herbal supplements, including green tea and Ginkgo biloba, can interact with prescription medications, according to a new research review published in the British Journal of Clinical Pharmacology. These interactions can make drugs less effective—and may even be dangerous or deadly. Doctors know that herbs can affect medication regimens, wrote the researchers, from the South African Medical Research Council, in their new paper. But because people often don’t disclose to their healthcare providers what over-the-counter drugs and supplements they’re taking, it’s difficult for scienti...
Source: TIME: Health - January 24, 2018 Category: Consumer Health News Authors: Amanda MacMillan Tags: Uncategorized are herbal supplements safe are supplements safe drug interactions drug side effects green tea healthytime herbal drugs medicine onetime supplement safety warfarin Source Type: news

FDA Mini-Sentinel Assessment Confirms Safety and Effectiveness of XARELTO ® (rivaroxaban) and its Association with a Lower Risk of Ischemic Stroke vs. Warfarin
(Source: Johnson and Johnson)
Source: Johnson and Johnson - January 16, 2018 Category: Pharmaceuticals Source Type: news

FDA report reaffirms safety profile and effectiveness of Bayer's Xarelto ® in routine clinical practice
A report from the U.S. Food and Drug Administration (FDA) published in Pharmacoepidemiology & Drug Safety confirms the safety profile and effectiveness of Xarelto® (rivaroxaban) in people with atrial fibrillation (AF). The study is based on electronic healthcare data within the Mini-Sentinel safety programme in the US, reporting data on a large real-world population of over 115,000 people prescribed rivaroxaban or warfarin. (Source: World Pharma News)
Source: World Pharma News - January 16, 2018 Category: Pharmaceuticals Tags: Featured Bayer Business and Industry Source Type: news

Apixaban cost effective versus warfarin for stroke prevention
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - December 1, 2017 Category: Drugs & Pharmacology Source Type: news

Mayo Clinic Q and A: Understanding and treating fibroelastomas
DEAR MAYO CLINIC:?I am an 83-year-old woman on warfarin because of atrial fibrillation, and I recently was diagnosed with a fibroelastoma.?Could you?give me a little information?on what this is, including the treatment and prognosis? ANSWER: Fibroelastomas are formally known as papillary fibroelastomas, or PFEs, and are sometimes called cardiac papillomas. These small, noncancerous tumors develop [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 28, 2017 Category: Databases & Libraries Source Type: news

Two new, large scale real-world analyses show fewer major bleeds and strokes with Pradaxa ® than with warfarin
Two new, large scale real-world analyses show fewer major bleeds and strokes with Pradaxa ® than with warfarin (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

ESC Congress 2014 Hot Line Session: Favourable effect of Pradaxa ® on kidney function over time compared to warfarin
ESC Congress 2014 Hot Line Session: Favourable effect of Pradaxa ® on kidney function over time compared to warfarin (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

Treatment with Pradaxa ® associated with better patient outcomes after a major bleeding event compared to warfarin
Treatment with Pradaxa ® associated with better patient outcomes after a major bleeding event compared to warfarin (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

Better outcome in case of major bleed for patients taking the anticoagulant Pradaxa ® compared to warfarin
Better outcome in case of major bleed for patients taking the anticoagulant Pradaxa ® compared to warfarin (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

Pradaxa ® (dabigatran etexilate) 150mg bid continues to be the only oral anticoagulant which showed superior ischaemic stroke reduction vs. warfarin in its pivotal study RE-LY® – Results of the ENGAGE AF-TIMI 48 trial published for edoxaban vs. warfarin do
Pradaxa ® (dabigatran etexilate) 150mg bid continues to be the only oral anticoagulant which showed superior ischaemic stroke reduction vs. warfarin in its pivotal study RE-LY® – Results of the ENGAGE AF-TIMI 48 trial published for edoxaban vs. warfarin do (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

NOACs Show Lower Risk of Adverse Renal Outcomes in A - Fib
Compared with warfarin, dabigatran and rivaroxaban linked to lower risk of adverse renal outcomes (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 21, 2017 Category: Cancer & Oncology Tags: Cardiology, Endocrinology, Family Medicine, Geriatrics, Gynecology, Internal Medicine, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Pathology, Pharmacy, Pulmonology, Journal, Source Type: news

Clinical outcomes and history of fall in patients with atrial fibrillation treated with oral anticoagulation: insights from the ARISTOTLE Trial - Rao MP, Vinereanu D, Wojdyla DM, Alexander JH, Atar D, Hylek EM, Hanna M, Wallentin L, Lopes RD, Gersh BJ, Granger CB.
PURPOSE: We assessed outcomes among anticoagulated patients with atrial fibrillation (AF) and a history of falling, and whether the benefits of apixaban versus warfarin are consistent in this population. METHODS: Of the 18,201 patients in ARISTOTLE... (Source: SafetyLit)
Source: SafetyLit - November 13, 2017 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Warfarin Linked to Lower Cancer Risk Warfarin Linked to Lower Cancer Risk
A large observational study finds a lower incidence of cancer in warfarin users, which could have important implications for the selection of medications for patients needing anticoagulation, researchers say.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 10, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Warfarin Use Tied to Lower Cancer Risk
Use of warfarin is associated with reduced incidence of cancer among older adults, according to an observational study in JAMA Internal Medicine. Using Norwegian registries... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 9, 2017 Category: Primary Care Source Type: news

Speed makes a difference when using clot-stabilising drug in severe bleeding
Immediate treatment with clot-stabilising drug can reduce risk of death due to blood loss by 70% Related items fromOnMedica Heavy menstrual bleeding Bleeding risk with long-term aspirin increases substantially with age Direct oral anticoagulants as safe as warfarin after VTE Include pregnant women in studies, urge researchers (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 8, 2017 Category: UK Health Source Type: news

Warfarin Use Tied to Lower Cancer Risk (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Use of warfarin is associated with reduced incidence of cancer among older adults, according to an observational study in JAMA Internal … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 7, 2017 Category: Primary Care Source Type: news

Lower risk of several cancers in people taking warfarin
Lower cancer incidence across a broad range of malignant neoplasms in people older than 50 (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 7, 2017 Category: UK Health Source Type: news

Medical News Today: Warfarin may prevent cancer
The anticoagulant warfarin may do more than prevent blood clots. Researchers have found that the drug may also protect against cancer development. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Blood thinning drugs lower the risk of cancers by 30%
Norwegian researchers have found warfarin was linked with lower risk of any cancer and of three of the most common cancers, prostate, lung, and breast but not bowel cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 6, 2017 Category: Consumer Health News Source Type: news

Cancer news: THIS common blood thinner linked to lower risk of THREE deadly types
CANCER remains a deadly condition globally, but a common medication - warfarin - has been linked to reduced risk of prostate, breast and lung types. (Source: Daily Express - Health)
Source: Daily Express - Health - November 6, 2017 Category: Consumer Health News Source Type: news

Could a Common Blood Thinner Lower Cancer Risk?
MONDAY, Nov. 6, 2017 -- A pill widely taken to prevent heart attack and stroke may also guard against cancer, new research suggests. Warfarin is an inexpensive blood thinner. It's typically prescribed for patients whose leg arteries are prone to... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 6, 2017 Category: General Medicine Source Type: news

Is anticoagulant warfarin associated with lower risk of cancer incidence?
(The JAMA Network Journals) Bottom Line: Use of the blood thinner warfarin was associated with a lower risk of new cancers in people over 50. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 6, 2017 Category: Cancer & Oncology Source Type: news

TCT 2017: Boston Scientific touts lowered hemorrhagic stroke rate, cost for patients in Watchman studies
Boston Scientific (NYSE:BSX) today released combined 5-year outcomes data from both the Prevail and Protect-AF study of its Watchman left atrial appendage closure device, touting it as a safe and effective an alternative to long-term warfarin therapy for patients with non-valvular atrial fibrillation. Five-year data from the Prevail study was published online today in the Journal of the American College of Cardiology. In both trials, the Marlborough, Mass.-based company compared the Watchman device to warfarin treatment for stroke prevention in patients with non-valvular AF with follow-ups out to five years. A combine...
Source: Mass Device - November 2, 2017 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Implants Cardiovascular Clinical Trials Boston Scientific Source Type: news

Blood-thinning drugs may reduce dementia risk in people with irregular heartbeats
Conclusion If you’ve been diagnosed with AF and you have been prescribed anticoagulant treatments such as warfarin or clopidogrel, we already know they protect you against having a stroke. This study suggests they may also help to protect you against dementia. Cutting the risk of dementia for people who have a raised risk because of AF would be an exciting step forward. Unfortunately, we can’t tell from this study whether the protection against dementia was down to the anticoagulants, because of the possible effect of unmeasured confounding factors. Usually, we would want to see a randomised controlled trial (R...
Source: NHS News Feed - October 25, 2017 Category: Consumer Health News Tags: Neurology Source Type: news

Dementia Less Likely With Oral Anticoagulants for Afib
(MedPage Today) -- Similar effect observed with NOACs, warfarin in Swedish registry data (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - October 25, 2017 Category: Psychiatry Source Type: news

Dementia news: Blood thinning drugs like warfarin 'could protect against dementia'
COMMON blood thinning drugs like warfarin have the power to protect against dementia, new research suggests. (Source: Daily Express - Health)
Source: Daily Express - Health - October 25, 2017 Category: Consumer Health News Source Type: news

New Dementia breakthrough: Blood-thinning drugs slash risk of being struck down
COMMON blood thinning drugs like warfarin have the power to protect against dementia, new research suggests. (Source: Daily Express - Health)
Source: Daily Express - Health - October 24, 2017 Category: Consumer Health News Source Type: news

Genetic testing helps determine safest dose of blood thinner for joint surgery patients
(Intermountain Medical Center) A new five-year study of nearly 1,600 patients finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 23, 2017 Category: Biology Source Type: news

Real-World Reassurance on Bleeding Risk With DOACs in VTE Real-World Reassurance on Bleeding Risk With DOACs in VTE
A new observational study found that the new direct oral anticoagulants are not associated with increased risk for major bleeding or all-cause mortality compared with warfarin in the first 3 months of treatment.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 19, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Newer Blood Thinners Don't Raise Bleeding Risk
Risk is similar to warfarin, study reports (Source: WebMD Health)
Source: WebMD Health - October 18, 2017 Category: Consumer Health News Source Type: news

Despite 'bad press,' new blood thinners aren't linked to greater bleeding risk: Study
New anti-clotting drugs -- like Xarelto, Pradaxa and Eliquis -- aren't linked with a higher risk of bleeding than the older drug warfarin, a new study finds (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 18, 2017 Category: Consumer Health News Source Type: news

Newer Blood Thinners May Not Bring Higher Bleeding Risk
Risk is similar to warfarin, study reports Source: HealthDay Related MedlinePlus Pages: Atrial Fibrillation, Blood Thinners, Deep Vein Thrombosis (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 18, 2017 Category: Consumer Health News Source Type: news

Newer Blood Thinners May Not Bring Higher Bleeding Risk
WEDNESDAY, Oct. 18, 2017 -- New anti-clotting drugs -- like Xarelto, Pradaxa and Eliquis -- aren't linked with a higher risk of bleeding than the older drug warfarin, a new study finds. Many patients who suffer from blood clots in their legs --... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 18, 2017 Category: General Medicine Source Type: news