Drugs to Avoid in Patients on DOACs Drugs to Avoid in Patients on DOACs
DOACs overall have substantially fewer drug-drug interactions than warfarin, but there are still a few to watch out for.Medscape Internal Medicine (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - July 23, 2020 Category: Cardiology Tags: Cardiology Clinical Case Source Type: news

DOACs Linked to Lower Fracture Risk vs Warfarin in AFib Patients DOACs Linked to Lower Fracture Risk vs Warfarin in AFib Patients
A recent population-based cohort study is one of the latest reports to suggest direct oral anticoagulants could have an edge over warfarin for preventing fractures.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - May 22, 2020 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Osteoporotic Fracture Risk Lower for DOAC Than Warfarin in A-Fib
MONDAY, May 18, 2020 -- For patients with atrial fibrillation (AF), the risk for osteoporotic fracture appears to be lower with direct oral anticoagulant (DOAC) use compared with warfarin use, according to a study published online May 19 in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 18, 2020 Category: Pharmaceuticals Source Type: news

AMP recommends minimum set of pharmacogenetic alleles to help standardize clinical genotyping testing for warfarin response
(Association for Molecular Pathology) AMP has published consensus, evidence-based recommendations to aid in the design, validation and interpretation of clinical genotyping tests for the prediction of warfarin response. The manuscript, 'Recommendations for Clinical Warfarin Sensitivity Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists,' was released online ahead of publication in The Journal of Molecular Diagnostics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 5, 2020 Category: International Medicine & Public Health Source Type: news

Costs in warfarin-sensitive versus warfarin-insensitive patients
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - May 1, 2020 Category: Drugs & Pharmacology Source Type: news

Cautions Raised Against Off-Label DOACs to Clear LV Thrombi Cautions Raised Against Off-Label DOACs to Clear LV Thrombi
Oral anticoagulation rules for left ventricular thrombus, but trial guidance is in short supply. Tempting as they may be for the indication, the newer agents may not protect as well as warfarin.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - April 29, 2020 Category: Cardiology Tags: Cardiology News Source Type: news

Vitamin K Antagonists and Osteoporotic Fractures Vitamin K Antagonists and Osteoporotic Fractures
A new study compared the fracture risks associated with NOACs vs. warfarin among AF patients on anticoagulant therapy. Which presents a better safety profile as it relates to bone health?European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 13, 2020 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Edoxaban Noninferior to Warfarin After Valve Surgery? Edoxaban Noninferior to Warfarin After Valve Surgery?
The first randomized trial comparing a DOAC with warfarin after bioprosthetic valve replacement surgery has been reported, but the question remains whether anticoagulation is needed at all.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - April 7, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Landmark Phase 3 VOYAGER PAD Study of XARELTO ® (rivaroxaban) Plus Aspirin Shows Significant Benefit in Patients with Symptomatic Peripheral Artery Disease (PAD) after Lower-Extremity Revascularization
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI[1] major bleeding. VOYAGER PAD is the only study to show a significant benefi...
Source: Johnson and Johnson - March 28, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Highlights Continued Commitment to Cardiovascular & Metabolic Healthcare Solutions with Late-Breaking Data at the First Fully Virtual American College of Cardiology Scientific Session
RARITAN, N.J., March 20, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that it will unveil late-breaking data from its leading cardiovascular and metabolism portfolio during the virtual American College of Cardiology’s 69th Annual Scientific Session together with the World Congress of Cardiology (ACC.20/WCC) on March 28-30, 2020. Notably, four late-breaking abstracts for XARELTO® (rivaroxaban) will be presented, including data from the Phase 3 VOYAGER PAD study in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization.Click to...
Source: Johnson and Johnson - March 20, 2020 Category: Pharmaceuticals Source Type: news

Stroke Risk in AF Patients on Rivaroxaban or Warfarin Stroke Risk in AF Patients on Rivaroxaban or Warfarin
This study compared the risk of stroke and all-cause mortality in patients taking rivaroxaban or warfarin for nonvalvular atrial fibrillation.Stroke (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 17, 2020 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

AUGUSTUS: Apixaban Bests Warfarin Despite Prior Stroke AUGUSTUS: Apixaban Bests Warfarin Despite Prior Stroke
In a prespecified secondary analysis of patients with a history of stroke, TIA, or thromboembolism, apixaban maintained an advantage over warfarin.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - March 10, 2020 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Minorities With ESRD and Afib Less Likely to Fill Prescriptions for Warfarin Minorities With ESRD and Afib Less Likely to Fill Prescriptions for Warfarin
Minority patients with end-stage renal disease (ESRD) and atrial fibrillation were less likely than whites to fill warfarin prescriptions, even though they were more likely to experience a stroke, researchers say.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 27, 2020 Category: Intensive Care Tags: Nephrology News Source Type: news

Secondary analysis confirms safety of blood thinning agent
(American Heart Association) The blood thinner apixaban, which treats and prevents blood clots in some people with irregular heart rhythm, is safe and effective in stroke patients. Apixaban is associated with less bleeding, death and hospitalization than warfarin. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 21, 2020 Category: International Medicine & Public Health Source Type: news

Warfarin Administration Time and Anticoagulation Stability Warfarin Administration Time and Anticoagulation Stability
Does it really matter if warfarin is taken in the evening or the morning?Annals of Family Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 11, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Compared With Warfarin, Non-Vitamin K Antagonist Oral Anticoagulants May Better Limit Risks to Bone Health
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - January 25, 2020 Category: Orthopaedics Tags: Trends and Innovations Source Type: news

Time of Day for Taking Warfarin Does Not Matter
WEDNESDAY, Jan. 22, 2020 -- Time of day for taking warfarin makes no difference on the drug's effectiveness, according to a study published in the January/February issue of the Annals of Family Medicine. Scott R. Garrison, M.D., Ph.D., from... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 22, 2020 Category: Pharmaceuticals Source Type: news

Do You Take Warfarin? Time of Day Might Not Matter
FRIDAY, Jan. 17, 2020 -- Patients taking the blood thinner warfarin have been told that it should be taken at night, but a new study found the time of day doesn't matter. " Whether warfarin is taken in the morning, or the evening, its therapeutic... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 17, 2020 Category: General Medicine Source Type: news

Fracture Risk Higher With Warfarin Vs DOACs Fracture Risk Higher With Warfarin Vs DOACs
Warfarin is associated with an increased risk of fractures compared with a direct oral anticoagulant (DOAC), a large real-world analysis has found.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - November 28, 2019 Category: Orthopaedics Tags: Cardiology News Source Type: news

Delayed intracranial hemorrhage in anticoagulated geriatric patients after ground level falls - Cocca AT, Privette A, Leon SM, Crookes BA, Hall G, Lena J, Eriksson EA.
BACKGROUND: The reported risk of delayed intracranial hemorrhage (ICH) in a trauma patient on warfarin is estimated to be between 0.6% and 6%. The risk of delayed ICH in trauma patients taking novel oral anticoagulants (NOACs) is not well-defined. ... (Source: SafetyLit)
Source: SafetyLit - November 23, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Risks After GI Bleeding in Anticoagulant, Antiplatelet Users Risks After GI Bleeding in Anticoagulant, Antiplatelet Users
When is it safe to resume aspirin or warfarin therapy after a major GI bleed?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 13, 2019 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Low-Intensity Warfarin Not Noninferior in Hip, Knee Surgery
TUESDAY, Nov. 5, 2019 -- Among older patients undergoing hip or knee replacement, low-intensity compared with standard-intensity warfarin prophylaxis did not meet the noninferiority criterion for the composite outcome of risk of venous... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 5, 2019 Category: Pharmaceuticals Source Type: news

DOACs Tied to Lower Fracture Risk vs Warfarin in AF DOACs Tied to Lower Fracture Risk vs Warfarin in AF
An observational study suggests all oral anticoagulants are not created equal: treatment with DOACs was associated with a lower risk for osteoporotic fractures than warfarin.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 22, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Rivaroxaban Misfires in Antiphospholipid Syndrome Rivaroxaban Misfires in Antiphospholipid Syndrome
Rivaroxaban not only failed to show noninferiority to warfarin, but trended toward higher thrombosis risk in patients with APS.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - October 17, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Rivaroxaban Cuts Recurrent Blood Clots in Obese Patients
Patients on rivaroxaban also have lower health care resource utilization than those on warfarin (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 30, 2019 Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Internal Medicine, Oncology, Pharmacy, Journal, Source Type: news

Rivaroxaban Cuts Recurrent Blood Clots in Obese Patients
MONDAY, Sept. 30, 2019 -- Real-world evidence shows that rivaroxaban reduces the risk for recurrent venous thromboembolism (VTE) in morbidly obese patients, with similar safety and efficacy as warfarin, according to a study published in the October... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 30, 2019 Category: Pharmaceuticals Source Type: news

Dying to be ill: Munchausen meets warfarin overdose - Akella P, Jindal V, Maradana S, Siddiqui AD.
Patients with severe coagulopathy related to vitamin K deficient proteins can be associated with surreptitious ingestion of vitamin K antagonists. Our patient presented acutely with extensive ecchymosis, gingival bleeding and hematuria. Her initial PT and ... (Source: SafetyLit)
Source: SafetyLit - September 28, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

XARELTO ® (rivaroxaban) Reduces Recurrent Blood Clots and Total Medical Costs in Morbidly Obese Patients
New real-world study of patients with venous thromboembolism (VTE) and morbid obesity shows safety and effectiveness of XARELTO ® were similar to warfarin, with significantly less healthcare resource utilization (HRU) and total medical costs (Source: Johnson and Johnson)
Source: Johnson and Johnson - September 20, 2019 Category: Pharmaceuticals Source Type: news

Comparisons Between OACs Among Older Nonvalvular AF Patients Comparisons Between OACs Among Older Nonvalvular AF Patients
This study compared the risk of stroke and major bleeding with NOACs vs. warfarin among patients 80 years of age and older with nonvalvular atrial fibrillation.Journal of the American Geriatrics Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 13, 2019 Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news

For Men, Living Alone May Mean Poorer Control of Blood-Thinning Meds
MONDAY, Sept. 2, 2019 -- Men who are on the blood-thinning drug warfarin have more difficulty taking the medication if they live alone, but the same is not true for women, a new study finds. Warfarin (brand-name Coumadin) is a common anti-clotting... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 2, 2019 Category: General Medicine Source Type: news

Anniversary of the pivotal RE-LY ® trial marks a decade of innovation for stroke prevention in AF patients
Boehringer Ingelheim today announces the ten-year anniversary of the RE-LY® trial publication(1-3) recognising the contribution made in the decade since by patients, healthcare professionals (HCPs) and researchers. In the fifty years prior, warfarin had been the standard of care for stroke prevention in atrial fibrillation (SPAF). (Source: World Pharma News)
Source: World Pharma News - August 30, 2019 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

Docs Still in Dark on Anticoagulant Choice in Severe Kidney Disease Docs Still in Dark on Anticoagulant Choice in Severe Kidney Disease
Although NOACs offer"similar or greater benefit" over warfarin-like drugs in early chronic kidney disease, lack of evidence in severe disease makes anticoagulant choice a judgment call, say experts.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - July 16, 2019 Category: Neurology Tags: Nephrology News Source Type: news

History of Liver Disease Does Not Impact Efficacy of Edoxaban
TUESDAY, July 9, 2019 -- For patients with atrial fibrillation (AF), the efficacy and safety of edoxaban versus warfarin is not altered with a history of liver disease, according to a study published in the July 16 issue of the Journal of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 9, 2019 Category: Pharmaceuticals Source Type: news

Antithrombotic agents and traumatic brain injury in the elderly population: hemorrhage patterns and outcomes - Scotti P, S éguin C, Lo BWY, De Guise E, Troquet JM, Marcoux J.
OBJECTIVE: Among the elderly, use of antithrombotics (ATs), antiplatelets (APs; aspirin, clopidogrel), and/or anticoagulants (ACs; warfarin, direct oral ACs [DOACs; dabigatran, rivaroxaban, apixaban]) to prevent thromboembolic events must be carefully weig... (Source: SafetyLit)
Source: SafetyLit - July 8, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

DAPT for Preventing Thrombosis in Antiphospholipid Syndrome DAPT for Preventing Thrombosis in Antiphospholipid Syndrome
Can dual antiplatelet therapy effectively prevent thrombosis recurrence in patients with antiphospholipid syndrome? How does it compare to warfarin?Rheumatology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 4, 2019 Category: Allergy & Immunology Tags: Rheumatology Journal Article Source Type: news

Saving the Brain From Catheter Ablation of AF Saving the Brain From Catheter Ablation of AF
A new study examines when is it appropriate to stop DOACs before catheter ablation of AF. Does discontinuation hold the same peri-procedural risk of stroke as was seen with warfarin discontinuation?European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 26, 2019 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Plavix (clopidogrel) vs. Coumadin (warfarin)
Title: Plavix (clopidogrel) vs. Coumadin (warfarin)Category: MedicationsCreated: 6/25/2019 12:00:00 AMLast Editorial Review: 6/25/2019 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - June 25, 2019 Category: Cardiology Source Type: news

Study Refutes Notion That People on Warfarin Shouldn't Eat Leafy Greens
Title: Study Refutes Notion That People on Warfarin Shouldn't Eat Leafy GreensCategory: Health NewsCreated: 6/11/2019 12:00:00 AMLast Editorial Review: 6/12/2019 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - June 12, 2019 Category: Cardiology Source Type: news

Study: Leafy Greens OK For People on Warfarin
The results of the small study suggest that taking in more vitamin K, not less, might help patients on warfarin (Coumadin). (Source: WebMD Health)
Source: WebMD Health - June 11, 2019 Category: Consumer Health News Source Type: news

Vitamin K Can Up Anticoagulation Stability in Patients on Warfarin
TUESDAY, June 11, 2019 -- Increasing vitamin K (VK) intake through dietary strategies improves the anticoagulation stability of warfarin-treated patients, according to a study presented during Nutrition 2019, the annual meeting of the American... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 11, 2019 Category: Pharmaceuticals Source Type: news

Study Refutes Notion That People on Warfarin Shouldn't Eat Leafy Greens
TUESDAY, June 11, 2019 -- Spinach-loving seniors, rejoice. A new study suggests that -- despite doctor warnings to the contrary -- you can eat leafy greens rich in vitamin K if you are taking the blood thinner warfarin. In fact, " I think all... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 11, 2019 Category: General Medicine Source Type: news

Boston Sci Initiates New Watchman FLX Study
Boston Scientific has initiated a study that will compare the Watchman FLX left atrial appendage (LAA) closure device’s safety and effectiveness to that of anticoagulants for reducing stroke risk in atrial fibrillation patients in a new trial. The randomized, controlled OPTION trial will enroll 1,600 patients with non-valvular AFib who are suitable for oral anticoagulants (OAC) therapy and have recently had or will have an ablation. Patients at as many as 130 global sites will be randomized to receive the newest-generation Watchman FLX device or an OAC, inclusive of commonly prescribed direct oral anticoa...
Source: MDDI - May 24, 2019 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Business Source Type: news

Clinically Relevant Drug-Drug Interactions in Primary Care Clinically Relevant Drug-Drug Interactions in Primary Care
Review common and predictable drug interactions associated with antimicrobials, warfarin, amiodarone, antihypertensives, and opioids.American Family Physician (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2019 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Low-Dose Aspirin Linked To Bleeding In The Skull, New Report Says
(CNN) — Taking low-dose aspirin to prevent heart disease and stroke is associated with an increased risk of bleeding in the skull in people without a history of those conditions, according to a new report. Researchers analyzed data from 13 previous studies in which over 130,000 people ages 42 to 74, who didn’t have a history of heart disease or stroke, were given either aspirin or a placebo for the prevention of these conditions. All the trials reported on the risk of head bleeding. People who took the placebo had a 0.46% risk of having a head bleed during the combined trial periods. For those who took aspirin,...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 13, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News aspirin CNN Source Type: news

Independent large real-world study comparing NOACs in AF-patients
The results from an independent retrospective comparative study, published in January 2019 in the American Journal of Medicine, showed that dabigatran was associated with a more favourable benefit-harm profile than both warfarin and rivaroxaban. (Source: World Pharma News)
Source: World Pharma News - April 16, 2019 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

Real-world-study-comparing-NOACs-in-AF-patients
Independent large real-world study comparing NOACs in AF-patientsA recently published large retrospective comparative study investigated stroke, bleeding and mortality risks in older US Medicare patients treated with commonly marketed oral anticoagulants for non-valvular atrial fibrillation1  Results of the real-world study showed that Pradaxa ® (dabigatran etexilate) was associated with a more favourable benefit-risk profile in comparison to both warfarin and rivaroxaban1Data from an earlier FDA-funded Medicare study published in 2015, which investigated cardiovascular, bleeding and mortality risks among patients...
Source: Boehringer Ingelheim Corporate News - April 15, 2019 Category: Research Source Type: news

FDA warns about risks of using home use test strips that are pre-owned or not authorized for sale in U.S., including those for glucose, warfarin
(Source: Food and Drug Administration)
Source: Food and Drug Administration - April 8, 2019 Category: American Health Source Type: news

Daily Aspirin No Longer Recommended To Prevent Heart Attacks In Older Adults
(CNN) — If you’re a healthy older adult looking for ways to reduce your risk of heart attack and stroke, don’t turn to that age-old standby: daily low-dose aspirin. It’s no longer recommended as a preventative for older adults who don’t have a high risk or existing heart disease, according to guidelines announced Sunday by the American College of Cardiology and the American Heart Association. “For the most part, we are now much better at treating risk factors such as hypertension, diabetes and especially high cholesterol,” said North Carolina cardiologist Dr. Kevin Campbell, who wa...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 18, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News aspirin CNN Source Type: news

XARELTO ® (rivaroxaban) Significantly Reduced the Risk of Overall Strokes and the Most Severe Strokes and Was Associated with Fewer Stroke-Related Deaths in the Real World Versus Warfarin in Patients with Nonvalvular Atrial Fibrillation
(Source: Johnson and Johnson)
Source: Johnson and Johnson - March 18, 2019 Category: Pharmaceuticals Source Type: news

Direct Oral Anticoagulants of Benefit in Afib With Mitral Stenosis (CME/CE)
(MedPage Today) -- DOACs linked with lower rates of thromboembolism than warfarin and just as effective in preventing hemorrhagic strokes (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - March 17, 2019 Category: Urology & Nephrology Source Type: news