Stroke Rounds: Fewer Strokes in High-Risk Patients
(MedPage Today) -- Ischemic stroke rates dropped as warfarin use increased among Medicare beneficiaries over a 19-year period -- even among groups that have not been well represented in clinical trials, including the elderly, women, and blacks, researchers found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 24, 2014 Category: Cardiology Source Type: news

Aspirin 'is wrong drug for 200k heart patients' say NHS guidelines
Experts say aspirin being prescribed for strokes caused by an irregular heartbeat can be more harmful than anti-clotting agents or the drug warfarin. (Source: the Mail online | Health)
Source: the Mail online | Health - June 19, 2014 Category: Consumer Health News Source Type: news

Nice: Aspirin has all of the risks but few of the benefits
Dr Campbell Cowan, chair of Nice's Guideline Development Group, says that aspirin has never been as effective as warfarin in preventing strokes (Source: Telegraph Health)
Source: Telegraph Health - June 18, 2014 Category: Consumer Health News Tags: heart conditions strokes atrial fibrillation anticoagulatio health drugs health service aspirin heart disease NHS anticoagulant AF warfarin Source Type: news

Stroke Rounds: No Help From Genotype-Guided Warfarin Dosing
(MedPage Today) -- Using a patient?s genotype to guide the initial dosing of warfarin or its analogues does not appear to be better than dosing based on clinical characteristics, a meta-analysis showed. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - June 17, 2014 Category: Primary Care Source Type: news

Cardio Notes: Xarelto for Seniors, Carotid Stenting Death (CME/CE)
(MedPage Today) -- Rivaroxaban (Xarelto) matched warfarin in both older and younger patients. Also, the risk of dying in the month after carotid artery stenting varied to a large extent across U.S. hospitals. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - June 9, 2014 Category: Endocrinology Source Type: news

Anticoagulants could have reduced stroke risk
A hospital doctor was shocked that a woman with AF was not prescribed warfarin, says Charlotte MacNeil (Source: Telegraph Health)
Source: Telegraph Health - June 9, 2014 Category: Consumer Health News Source Type: news

Age 75+ No Bar to Rivaroxaban Benefit vs Warfarin: ROCKET-AFAge 75+ No Bar to Rivaroxaban Benefit vs Warfarin: ROCKET-AF
The trial's very elderly had more clinical events and bleeding issues than younger patients, but their relative benefit from the new oral anticoagulant was similar. Heartwire (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 7, 2014 Category: Cardiology Tags: Cardiology News Source Type: news

Episode #4: Poisoning and the diagnosis of brain death
Conclusion: unclear how long to wait before pronouncing brain death as many factors such as pharmacogenetics can alter normal metabolism   Summary Drug overdose can mimic brain death Be especially cautious in overdose involving the scary B’s: baclofen, barbiturate, benzodiazepine The 3-5 half life rule for drug clearance cannot be applied in the cases of overdose Half lives are measured at therapeutic levels Multiple other factors can alter metabolism in overdoses, such as pharmacogenetics, and cross reactivity with other ingestants Consult a toxicologist if there is any question regarding possible overdose...
Source: The Poison Review - May 21, 2014 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

Life coach: is honey healthier than sugar?
Our health experts answer your questions. This week: honey, triathlon training and green veg alternatives (Source: Telegraph Health)
Source: Telegraph Health - May 20, 2014 Category: Consumer Health News Tags: health green veg alternatives health experts sugar health advice honey green vegetables triathlon training warfarin Source Type: news

Life coach: is honey healthier than sugar?
Our health experts answer your questions. This week: honey, triathlon training and green veg alternatives (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - May 20, 2014 Category: Consumer Health News Tags: health green veg alternatives health experts sugar health advice honey green vegetables triathlon training warfarin Source Type: news

FDA releases safety data on dabigatran bleeding risks relative to warfarin
Read the full story on MD Consult: FDA releases safety data on dabigatran bleeding risks relative to warfarin (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - May 16, 2014 Category: Journals (General) Source Type: news

Warfarin for Long-term Psychosis Remission?Warfarin for Long-term Psychosis Remission?
Patients with schizophrenia treated with warfarin for deep venous thrombosis attained remission of psychotic symptoms and remained free of psychotropics for up to 11 years. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - May 15, 2014 Category: Psychiatry Tags: Psychiatry News Source Type: news

Class I Medical Device Recall: Alere INRatio2 PT/INR Professional Test Strips - Results Disagree with the Confirmed PT/INR Reference Test Results Performed by Central Laboratory
The Alere lNRatio2 PT/INR Monitoring System (Professional Use) is used for quantitative determination of international normalized ratio (INR) in fresh, capillary whole blood to monitor the effect of warfarin on clotting time (prothrombin time)... (Source: Food and Drug Adminstration (FDA): CDRHNew)
Source: Food and Drug Adminstration (FDA): CDRHNew - May 15, 2014 Category: Medical Equipment Source Type: news

FDA Review Finds No Increased Risk of MI With Dabigatran (Pradaxa)FDA Review Finds No Increased Risk of MI With Dabigatran (Pradaxa)
The latest FDA study to tackle dabigatran's risk/benefit profile also found fewer ischemic strokes, intracranial bleeds, and deaths with dabigatran but fewer major GI bleeds with warfarin. News Alerts (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - May 14, 2014 Category: Cardiology Tags: Cardiology News Alert Source Type: news

Pradaxa (dabigatran): Drug Safety Communication - Lower Risk for Stroke and Death, but Higher Risk for GI Bleeding Compared to Warfarin
Study finds lower risk of clot-related strokes, bleeding in brain, and death for Pradaxia versus warfarin, but increased risk of major GI bleeding. (Source: FDA MedWatch)
Source: FDA MedWatch - May 13, 2014 Category: American Health Source Type: news

FDA Study Offers Reassurance About Boehringer Ingelheim's Pradaxa
In the latest development in its ongoing review of the new oral anticoagulant dabigatran (Pradaxa, Boehringer Ingelheim), the FDA today offered largely reassuring news about the sometimes controversial drug. The FDA study of 134,000 Medicare patients found that dabigatran was associated with a reduced risk for ischemic stroke, bleeding in the brain, and death, compared to warfarin. But the study also found that, dabigatran was associated with an increased risk for major gastrointestinal bleeding. There was no difference between the drugs in the risk of MI. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - May 13, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

HRS2014: Devices combat drugs for treatment of AF stroke-risk patients
Researchers say that devices used to close off the heart's left atrial appendage appear as good as anti-coagulation drugs for treating certain patients with an increased risk of having a stroke. New clinical data continues to suggest that left atrial appendage occlusion devices may pose an improvement over warfarin drug regimens for treating patients at increased risk of stroke, researchers reported today. Boston Scientific, Coherex Medical, Heart Rhythm Society, St. Jude MedicalNews Well, Cardiac Assist Devices, Cardiac Rhythm Management, Conference coverage, HRS 2014, Strokeread more (Source: Mass Device)
Source: Mass Device - May 8, 2014 Category: Medical Equipment Authors: Arezu Sarvestani Source Type: news

Dr Le Fanu's online health clinic, Friday 2nd May 2014
Concerned about aches and pains? Worried about a medical condition? You can email your questions confidentially to Dr Le Fanu at drjames@telegraph.co.uk. Answers will be published in the health section of the Telegraph website every Friday. Today: difficulty reading on wakening, chocolate and sneezing, blocked nose connection to a possible nickel allergy, e-cigarettes, thyroid problems and Warfarin side effects. (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - May 2, 2014 Category: Consumer Health News Source Type: news

Edible flowers not proven to prevent cancer
Conclusion The current study has identified the levels of phenolic compounds in certain edible flowers. These compounds have antioxidant compounds, and antioxidants have been suggested to have various health benefits, including fighting cancer and heart disease. However, the current study has not assessed whether eating these flowers could have effects on human health, or at what levels they would need to be consumed to have any effects. A Cochrane systematic review pooled data on the effects of antioxidant supplements tested in clinical trials and found no evidence of beneficial effects on survival in healthy people or p...
Source: NHS News Feed - April 23, 2014 Category: Consumer Health News Tags: Cancer Food/diet Source Type: news

Taking Blood Thinners with Certain Painkillers May Raise Bleeding Risk
People using warfarin or Xarelto should avoid aspirin, ibuprofen and other NSAIDs, study finds Source: HealthDay Related MedlinePlus Pages: Bleeding, Blood Thinners, Pain Relievers (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - April 14, 2014 Category: Consumer Health News Source Type: news

Dr Le Fanu's online health clinic, Friday 11th April 2014
Concerned about aches and pains? Worried about a medical condition? You can email your questions confidentially to Dr Le Fanu at drjames@telegraph.co.uk. Answers will be published in the health section of the Telegraph website every Friday. Today: Warfarin, statins, migraine, sweating and phantom socks! (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - April 11, 2014 Category: Consumer Health News Source Type: news

Hot Topics: New Blood Thinners to Prevent Stroke
(MedPage Today) -- Does the lack of a blood-monitoring recommendation for new oral anticoagulants create a barrier to their wider adoption in place of warfarin for stroke prevention? Three well-known specialists addressed the question. (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - April 7, 2014 Category: Neurology Source Type: news

Daiichi Sankyo Begins Phase 3 Study For Edoxaban
Daiichi Sankyo announced that it has initiated enrollment of patients into the multinational Phase III study ENSURE-AF evaluating the safety and efficacy of edoxaban against enoxaparin and warfarin. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - April 4, 2014 Category: Pharmaceuticals Source Type: news

Aspirin linked to better colon cancer survival
Low-dose aspirin improves survival in some types of colon cancerRelated items from OnMedicaAspirin could also treat cancer, research suggestsAspirin as effective as warfarin for heart patientsAspirin to fight cancer is safe after screeningNICE says far more people should take statinsNICE recommends Herceptin for gastric cancer (Source: OnMedica Latest News)
Source: OnMedica Latest News - April 1, 2014 Category: UK Health Source Type: news

Patient Outcomes Using the European Label for DabigatranPatient Outcomes Using the European Label for Dabigatran
Is ''EU label simulated dabigatran treatment'' associated with superior efficacy and safety compared to warfarin? (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - March 28, 2014 Category: Cardiology Tags: Cardiology Journal Article Source Type: news

American Journal of Managed Care Highlights STABLE Study on Warfarin
Lead Investigator Discusses Findings With AJMC, Says Results Show Importance of Self-Testing(PRWeb March 26, 2014)Read the full story at http://www.prweb.com/releases/2014/03/prweb11703272.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 27, 2014 Category: Pharmaceuticals Source Type: news

Stroke Rounds: Warfarin No Help for Dialysis Patients
(MedPage Today) -- The risk-benefit balance did not appear to be favorable for warfarin in patients with atrial fibrillation who were undergoing dialysis, a retrospective study showed. (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - March 25, 2014 Category: Neurology Source Type: news

Pharmacogenetics-Based Warfarin Dosing in ChildrenPharmacogenetics-Based Warfarin Dosing in Children
This review describes the two main types of pharmacogenetic-based warfarin dose prediction models and their applicability to children. What are their respective advantages and limitations? Pharmacogenomics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 20, 2014 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Atrial Fibrillation Treated With Vitamin K AntagonismAtrial Fibrillation Treated With Vitamin K Antagonism
How does rivaroxaban compare with warfarin for reductions in cardiovascular events -- in patients with atrial fibrillation and a prior MI? European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2014 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Apixaban vs. Warfarin and Aspirin in Atrial FibrillationApixaban vs. Warfarin and Aspirin in Atrial Fibrillation
Compare the impact of two regimens on stroke and major bleeding -- in patients with atrial fibrillation. European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 11, 2014 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Genotype-Guided Drug Therapy in CardiologyGenotype-Guided Drug Therapy in Cardiology
From clopidogrel to warfarin and statins, genotyping can affect drug metabolism but should genetics guide pharmacotherapy? Drs. Harrington, Ohman, Mega, and Robinson have a spirited discussion. theheart.org on Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - March 6, 2014 Category: Cardiology Tags: Cardiology Roundtable Source Type: news

Warfarin Good Even With Kidney Disease
(MedPage Today) -- Among patients with atrial fibrillation and a recent heart attack, warfarin use was associated with improved outcomes -- without excess bleeding -- regardless of the level of kidney function, a Swedish study showed. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 5, 2014 Category: Cardiology Source Type: news

Warfarin May Be Good Even With Kidney Disease
(MedPage Today) -- Among patients with atrial fibrillation and a recent heart attack, warfarin use was associated with improved outcomes -- without excess bleeding -- regardless of the level of kidney function, a Swedish study showed. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 5, 2014 Category: Primary Care Source Type: news

Warfarin Safe for Kidney Patients With Irregular Heartbeat: Study
Title: Warfarin Safe for Kidney Patients With Irregular Heartbeat: StudyCategory: Health NewsCreated: 3/4/2014 4:36:00 PMLast Editorial Review: 3/5/2014 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - March 5, 2014 Category: Cardiology Source Type: news

AFib Patients with Chronic Kidney Disease Also Benefit from Warfarin (FREE)
By Larry Husten A large observational study, published in JAMA, offers some reassurance that anticoagulation in atrial fibrillation patients who also have chronic kidney disease may be beneficial.Researchers in Sweden analyzed data from … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 5, 2014 Category: Primary Care Source Type: news

Even With CKD, Warfarin Safely Cuts Events in Post-MI AFEven With CKD, Warfarin Safely Cuts Events in Post-MI AF
Data from the venerable SWEDEHEART registry suggest that, contrary to some evidence in the literature, it's safe to give warfarin for AF in the setting of advanced renal disease. Heartwire (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - March 5, 2014 Category: Cardiology Tags: Cardiology News Source Type: news

Warfarin Benefits Extended To Patients with Chronic Kidney Disease
Anticoagulation is a cornerstone of therapy for atrial fibrillation because it lowers the heightened risk for stroke in this population. People with chronic kidney disease are also at increased risk for stroke, but the benefits of anticoagulation are less clear in this group, and anticoagulation is used less often in AF patients who have CKD. Now, a large observational study offers some reassurance that anticoagulation in AF patients with CKD may be beneficial. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 4, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Anti-coagulant treatment for atrial fibrillation does not worsen outcomes for patients with kidney disease
Although some research has suggested that the use of the anticoagulant warfarin for atrial fibrillation among patients with chronic kidney disease would increase the risk of death or stroke, a study that included more than 24,000 patients found a lower l-year risk of the combined outcomes of death, heart attack or stroke without a higher risk of bleeding, according to a study in JAMA. Juan Jesus Carrero, Ph.D. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 4, 2014 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Warfarin Safe for Kidney Patients with Irregular Heartbeat
Use of the blood thinner may safely ease stroke risk linked to atrial fibrillation, Swedish research finds Source: HealthDay Related MedlinePlus Pages: Blood Thinners, Chronic Kidney Disease (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 4, 2014 Category: Consumer Health News Source Type: news

In a Subanalysis, Eliquis(R) (apixaban) Reduced the Risk of Stroke and Demonstrated Fewer Major Bleeding Events versus Warfarin Consistently across Age Groups, Including Older Patients with Nonvalvular Atrial Fibrillation
Data from Phase 3 ARISTOTLE trial pre-specified subanalysis published in the European Heart Journal PRINCETON, N.J. & NEW YORK--(Healthcare Sales & Marketing Network)--Bristol-Myers Squibb Company (BMY) and Pfizer Inc. (PFE) today announced results of a... Biopharmaceuticals, CardiologyBristol-Myers Squibb, Pfizer, Eliquis, apixaban, atrial fibrillation, stroke (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 21, 2014 Category: Pharmaceuticals Source Type: news

Maybe Pradaxa (dabigatran) does need blood monitoring after all
2.5 out of 5 stars The Effect of Dabigatran Plasma Concentrations and Patient Characteristics on the Frequency of Ischemic Stroke and Major Bleeding in Atrial Fibrillation Patients. Reilly PA et al. J Am Coll Cardiol 2014 Feb 4;63:321-8. Abstract A must-read article in yesterday’s New York Times described the internal battle at Boehringer Ingelheim, the maker of Pradaxa (dabiagtran etexilate), concerning the publication of this study. A major marketing point posited in favor of dabigatran over warfarin for the prevention of stroke in patients with atrial fibrillation was that it did not require monitor...
Source: The Poison Review - February 7, 2014 Category: Toxicology Authors: Leon Tags: Medical bleeding blood testing boehringer ingelheim dabigatran pradaxa stroke Source Type: news

Novel Anticoagulants vs Warfarin: Latest AnalysesNovel Anticoagulants vs Warfarin: Latest Analyses
For patients with atrial fibrillation, 4 novel anticoagulants appear to be slightly more effective and safer than warfarin for preventing ischemic stroke. Medscape Neurology (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - January 30, 2014 Category: Drugs & Pharmacology Tags: Neurology & Neurosurgery Commentary Source Type: news

Aspirin still overprescribed for stroke prevention in AF
Data from the EORP Atrial Fibrillation General Pilot Registry of more than 3 100 patients in nine countries provides the most up-to-date picture of European cardiologists’ prescribing of antithrombotic treatment, which includes oral anticoagulation therapy (warfarin and the novel oral anticoagulants) and antiplatelet drugs (mainly aspirin). Topics: Atrial Fibrillation (Source: ESC News and Press)
Source: ESC News and Press - January 29, 2014 Category: Cardiology Source Type: news

Problems Persist Despite Gains In Oral Anticoagulant Use
Although significant progress has been made in recent years, a new survey from the European Society of Cardiology finds that there are still too many atrial fibrillation patients who are not taking the best medications to reduce their elevated risk of stroke. Many elderly patients are not receiving oral anticoagulants-- either traditional warfarin or one of the newer anticoagulants (Pradaxa, Boehringer Ingelheim, Xarelto, Johnson & Johnson; and Eliquis (Pfizer and BristolMyers Squibb)-- and overall too many patients are still taking aspirin, despite the fact that it is not recommended for this group of patients. (Sourc...
Source: Forbes.com Healthcare News - January 28, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Warfarin Reversal: Time for a Change?Warfarin Reversal: Time for a Change?
A recent study compares frozen plasma with prothrombin complex concentrate for warfarin reversal. Medscape Neurology (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - January 23, 2014 Category: Internal Medicine Tags: Neurology & Neurosurgery Commentary Source Type: news

URIs, Antibiotics Affect Warfarin (CME/CE)
(MedPage Today) -- Having an acute upper respiratory tract infection -- with or without treatment with an antibiotic -- may be associated with excessive anti-coagulation in patients taking warfarin, a retrospective study showed. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 20, 2014 Category: Cardiology Source Type: news

Cardio Notes: New Blood Test for Heart Attack?
(MedPage Today) -- A blood test might eventually help detect the early stages of a heart attack, and another challenger to warfarin takes its case to the FDA. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 13, 2014 Category: Primary Care Source Type: news

Pradaxa Being Reevaluated By FDA
Pradaxa (dabigatran), a relatively new anticoagulant used to treat non-valvular atrial fibrillation is being reassessed for safety by the FDA. Pradaxa is a fixed dose medication that is given twice daily and competes with Coumadin (warfarin), a more commonly used anticoagulant. Patients on Coumadin must have their blood monitored regularly, whereas Pradaxa does not require therapeutic monitoring. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - January 8, 2014 Category: Pharmaceuticals Source Type: news

GI Injury: Common With New Antiplatelets and Anticoagulants?GI Injury: Common With New Antiplatelets and Anticoagulants?
How does the risk for gastrointestinal bleeding with newer anticoagulants compare with that of warfarin or aspirin? Medscape Pharmacists (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 26, 2013 Category: Consumer Health News Tags: Gastroenterology Ask the Expert Source Type: news

In the first 30 days of warfarin use, risk of stroke increases among atrial fibrillation patients
Patients with atrial fibrillation - an irregular and often abnormally fast heartbeat- have nearly double the risk of suffering a stroke in the first 30 days after starting to take the anti-clotting drug warfarin compared to non-users, according to a study of over 70,000 patients.The study, published online in the European Heart Journal [1], found that the risk was particularly high in the first week after patients started to take the drug. In contrast, once the first 30 days had elapsed, the risk of a stroke was halved in patients taking warfarin compared to non-users. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 24, 2013 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news