Using Dental Pulp Stem Cells for Stroke Therapy

Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allowing for safer and more efficient induction of NSC. More closely related cells, such as DPSC, are potential candidates for manipulation along the neural lineage. They have provided encouraging outcomes in stroke models and their neural replacement potential may be enhanced if resembling NSC. With more research, the limitations of cellular reprogramming can be overcome, and efficient, safe and reproducible methods for NSC induction can be developed. Author Contributions MG: research and writing of manuscript. KK, SG, and SK: critical revision of manuscript for important intellectual content. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Funding MG is supported by an Australian Government Research T...
Source: Frontiers in Neurology - Category: Neurology Source Type: research