Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions
MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed.
We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, as to propose an onco-fetal origin of the polarization.
In addition to the well-characterized role in immunosuppression, MDSC possess potent pro-angiogenic capabilities, and actively participate in the resistance to VEGF-targeted therapy. Considering the crucial role of MDSC in inducing and regulating a permissive immune TME, in directly contributing to angiogenesis and tumor invasion, several strategies to therapeutically target these cells are currently being tested in clinic. Several pre-clinical studies show that targeting MDSC through multiple approaches helps to increases NK cells tumor activity augment the efficacy of anti-angiogenic therapy.
A better understanding of the link between MDSC-NK immunosuppressive network in TME and their influence on angiogenesis can be translated to new therapeutic targets.
Author Contributions
DN and AA: design, rev...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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