Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination
The leucine zipper–like transcriptional regulator 1 (LZTR1) protein, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, is implicated in human disease, yet its mechanism of action remains unknown. We found that Lztr1 haploinsufficiency in mice recapitulates Noonan syndrome phenotypes, whereas LZTR1 loss in Schwann cells drives dedifferentiation and proliferation. By trapping LZTR1 complexes from intact mammalian cells, we identified the guanosine triphosphatase RAS as a substrate for the LZTR1-CUL3 complex. Ubiquitome analysis showed that loss of Lztr1 abrogated Ras ubiquitination at lysine-170. LZTR1-mediated ...
Source: ScienceNOW - December 6, 2018 Category: Science Authors: Steklov, M., Pandolfi, S., Baietti, M. F., Batiuk, A., Carai, P., Najm, P., Zhang, M., Jang, H., Renzi, F., Cai, Y., Abbasi Asbagh, L., Pastor, T., De Troyer, M., Simicek, M., Radaelli, E., Brems, H., Legius, E., Tavernier, J., Gevaert, K., Impens, F., Me Tags: Medicine, Diseases, Molecular Biology reports Source Type: news
Baltimore biotech WindMIL Therapeutics raises $32.5 million
Baltimore biotechnology firm WindMIL Therapeutics has raised a $32.5 million to support clinical trials and further development for new cancer therapies. The Series B round was led by QiMing USA Venture Partners, the new U.S. entity of China firm QiMing. WindMIL, a cell therapy company, is previously backed by about $11 million in funding. WindMIL was founded out of Johns Hopkins University by researchers Kimberly Noonan and Dr. Ivan Borrello. Th e clinical stage company is working to develop… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 18, 2018 Category: American Health Authors: Morgan Eichensehr Source Type: news
Family income, maternal psychological distress and child socio-emotional behaviour: longitudinal findings from the UK Millennium Cohort Study - Noonan K, Burns R, Violato M.
The association between low family income and socio-emotional behaviour problems in early childhood has been well-documented, and maternal psychological distress is highlighted as central in mediating this relationship. However, whether this relationship h... (Source: SafetyLit)
Source: SafetyLit - June 4, 2018 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Behaviours preceding suicides at railway and underground locations: a multimethodological qualitative approach - Mackenzie JM, Borrill J, Hawkins E, Fields B, Kruger I, Noonan I, Marzano L.
OBJECTIVES: Suicides by train have devastating consequences for families, the rail industry, staff dealing with the aftermath of such incidents and potential witnesses. To reduce suicides and suicide attempts by rail, it is important to learn how safe inte... (Source: SafetyLit)
Source: SafetyLit - April 16, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner
Catalytically activating mutations in Ptpn11, which encodes the protein tyrosine phosphatase SHP2, cause 50% of Noonan syndrome (NS) cases, whereas inactivating mutations in Ptpn11 are responsible for nearly all cases of the similar, but distinct, developmental disorder Noonan syndrome with multiple lentigines (NSML; formerly called LEOPARD syndrome). However, both types of disease mutations are gain-of-function mutations because they cause SHP2 to constitutively adopt an open conformation. We found that the catalytic activity of SHP2 was required for the pathogenic effects of gain-of-function, disease-associated mutations...
Source: Signal Transduction Knowledge Environment - March 20, 2018 Category: Science Authors: Zheng, H., Yu, W.-M., Waclaw, R. R., Kontaridis, M. I., Neel, B. G., Qu, C.-K. Tags: STKE Research Articles Source Type: news
Have we really found Amelia Earhart's bones?
A new study claims that the Nikumaroro Island bones are those of the famous aviator. But some researchers remain skepticalFrom theheadlineslastweek, you would think that the Amelia Earhart mystery has finally been solved. Anew study published in Forensic Anthropology by Richard Jantz claims that a set of human remains found onNikumaroro Island are likely the bones of the pioneering aviator. If true, this is an exciting development. As theidentification of the remains of Richard III illustrated, solving important historical mysteries is extremely satisfying. But unlike the case of Richard III, not all biological anthropolog...
Source: Guardian Unlimited Science - March 16, 2018 Category: Science Authors: Jennifer Raff Tags: Science Amelia Earhart Anthropology Source Type: news
Interventions for eye movement disorders due to acquired brain injury - Rowe FJ, Hanna K, Evans JR, Noonan CP, Garcia-Finana M, Dodridge CS, Howard C, Jarvis KA, MacDiarmid SL, Maan T, North L, Rodgers H.
BACKGROUND: Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties. A wide range of interventions exist that... (Source: SafetyLit)
Source: SafetyLit - March 8, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
We Just Got One More Clue About Amelia Earhart ’s Final Resting Place
The legendary pilot Amelia Earhart famously disappeared during an ill-fated attempt to fly around the world in 1937. Earhart’s last whereabouts remain unknown, but a new study adds weight to one of the most popular theories about her final resting place. Bones found in 1940 on Nikumaroro Island — a western Pacific island near Earhart’s projected flight path — were initially thought to belong to the pilot, as they were found alongside a number of possessions that could have belonged to her, including a shoe; a box designed to hold a navigation device similar to the one used by Earhart’s navigat...
Source: TIME: Science - March 7, 2018 Category: Science Authors: Jamie Ducharme Tags: Uncategorized forensics healthytime onetime Source Type: news
Camden Coalition names new CEO
The Camden Coalition of Healthcare Providers named Kathleen Noonan as its new CEO. Noonan is the co-founder of PolicyLab, a research center at Children ’s Hospital of Philadelphia. “Kathleen emerged as the search committee’s unanimous choice,” said Joan Gray, chairwoman of the board of the Camden Coalition and assistant vice president for ambulatory services at Virtua Health in Camden. “Kathleen has worked closely with the Coalition, hel ping to refine the organization's clinical care model… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 2, 2018 Category: Pharmaceuticals Authors: John George Source Type: news
Infant health and future childhood adversity - Reichman NE, Corman H, Noonan K, Jimenez ME.
OBJECTIVE To investigate the extent to which disabling infant health conditions are associated with adverse childhood experiences at age 5. METHODS We conducted a secondary analysis of data from the Fragile Families and Child Wellbeing Study, a nat... (Source: SafetyLit)
Source: SafetyLit - January 3, 2018 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Quality of life and health utility scores among Canadian traumatic spinal cord injury patients - a national cross-sectional study - Iorio-Morin C, Noonan VK, White B, Noreau L, Leblond J, Dumont FS, Kwon BK, Dvorak MF, Dea N.
STUDY DESIGN: National, multicenter, cross-sectional study. OBJECTIVE: The goal of this study was to provide overall quality of life (QOL) and health utility (HU) values for patients with traumatic spinal cord injury (SCI) stratified by injury leve... (Source: SafetyLit)
Source: SafetyLit - December 4, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Impact of trauma system structure on injury outcomes: a systematic review and meta-analysis - Moore L, Champion H, Tardif PA, Kuimi BL, O'Reilly G, Leppaniemi A, Cameron P, Palmer CS, Abu-Zidan FM, Gabbe B, Gaarder C, Yanchar N, Stelfox HT, Coimbra R, Kortbeek J, Noonan VK, Gunning A, Gordon M, Khajanchi M, Porgo TV, Turgeon AF, Leenen L.
BACKGROUND: The effectiveness of trauma systems in decreasing injury mortality and morbidity has been well demonstrated. However, little is known about which components contribute to their effectiveness. We aimed to systematically review the evidence of th... (Source: SafetyLit)
Source: SafetyLit - October 30, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
WATCH: New documentary 'Heal' explores the power of the mind
Filmmaker Kelly Noonan Gores on her new film, "Heal." (Source: ABC News: Health)
Source: ABC News: Health - October 27, 2017 Category: Consumer Health News Tags: Health Source Type: news
Predicting injury severity and neurologic recovery after acute cervical spinal cord injury - a comparison of cerebrospinal fluid and magnetic resonance imaging biomarkers - Dalkilic T, Fallah N, Noonan VK, Salimi Elizei S, Dong K, Belanger LM, Ritchie L, Tsang A, Bourassa-Moreau E, Heran MKS, Paquette SJ, Ailon T, Dea N, Street J, Fisher CG, Dvorak MF, Kwon BK.
Biomarkers of acute human spinal cord injury (SCI) could provide a more objective measure of spinal cord damage and a better predictor of neurologic outcome than the current functional neurologic assessments. There has been growing interest in establishing... (Source: SafetyLit)
Source: SafetyLit - October 23, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
The prescription drug epidemic in the United States - efforts to improve prescribing (Safety-2016 abstract #377) - Baldwin G, Houry D, Noonan R.
BACKGROUND More than 145,000 people have died from overdoses involving prescription opioid pain relievers in the United States in the last decade and deaths have quadrupled since 1999. The quantity of opioids sold in the United States in 2011 was four time... (Source: SafetyLit)
Source: SafetyLit - September 11, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Fitness, fatness and active school commuting among Liverpool schoolchildren - Noonan RJ, Boddy LM, Knowles ZR, Fairclough SJ.
This study investigated differences in health outcomes between active and passive school commuters, and examined associations between parent perceptions of the neighborhood environment and active school commuting (ASC). One hundred-ninety-four children (10... (Source: SafetyLit)
Source: SafetyLit - September 1, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Feasibility and data quality of the National Spinal Cord Injury Registry of Iran (NSCIR-IR): a pilot study - Naghdi K, Azadmanjir Z, Saadat S, Abedi A, Koohi Habibi S, Derakhshan P, Safdarian M, Abdollah Zadegan S, Amirjamshidi A, Sharif-Alhoseini M, Arab Kheradmand J, Mohammadzadeh M, Zendehdel K, Khazaeipour Z, Hashemi SMR, Saberi H, Karimi Yarandi K, Ketabchi SE, Yousefzadeh-Chabok S, Heidari H, Sotodeh A, Pestei K, Ghodsi Z, Sadeghian F, Noonan V, Benzel EC, Oreilly G, Chapman J, Hagen EM, Fehlings MG, Vaccaro AR, Faghih Jooybari M, Zarei MR, Zafarghandi MR, Salamati P, Nezareh S, Khormali M, Sadeghi-Naini M, Jazayeri SB, Aarabi B, Rahimi-Movaghar V.
BACKGROUND: Spinal cord injury (SCI) is one of the most disabling consequences of trauma with unparalleled economic, social, and personal burden. Any attempt aimed at improving quality of care should be based on comprehensive and reliable data. This pilot ... (Source: SafetyLit)
Source: SafetyLit - August 30, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Fostering reproducibility in industry-academia research
Source: ScienceNOW - August 24, 2017 Category: Science Authors: Jasny, B. R., Wigginton, N., McNutt, M., Bubela, T., Buck, S., Cook-Deegan, R., Gardner, T., Hanson, B., Hustad, C., Kiermer, V., Lazer, D., Lupia, A., Manrai, A., McConnell, L., Noonan, K., Phimister, E., Simon, B., Strandburg, K., Summers, Z., Watts, D. Tags: Scientific Community p-forum Source Type: news
Facilitators and barriers to international collaboration in spinal cord injury: results from a survey of clinicians and researchers - Noonan VK, Chan E, Bassett-Spiers K, Berlowitz DJ, Biering-S ørensen F, Charlifue S, Graco M, Hayes KC, Horsewell J, Joshi P, Markelis D, Smith V, Waheed Z, Brown DJ.
International collaboration in spinal cord injury (SCI) clinical research is necessary to overcome the challenges often encountered by clinicians and researchers including participant recruitment, high cost and the need for highly specialized expertise. Ho... (Source: SafetyLit)
Source: SafetyLit - July 25, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Flood risk management: exploring the impacts of the community rating system program on poverty and income inequality - Noonan DS, Sadiq AA.
Flooding remains a major problem for the United States, causing numerous deaths and damaging countless properties. To reduce the impact of flooding on communities, the U.S. government established the Community Rating System (CRS) in 1990 to reduce flood da... (Source: SafetyLit)
Source: SafetyLit - July 1, 2017 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
Using evidence to inform practice and policy to enhance the quality of care for persons with traumatic spinal cord injury - Fehlings MG, Cheng CL, Chan E, Thorogood NP, Noonan VK, Ahn H, Bailey C, Singh A, Dvorak MF.
In today's economic climate there is a need to demonstrate a return on investment for healthcare spending and for clinical practice and policy to be informed by evidence. Navigating this process is difficult for decision-makers, clinicians and researchers ... (Source: SafetyLit)
Source: SafetyLit - June 10, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Impact of therapy on recovery during rehabilitation in patients with traumatic spinal cord injury - Truchon C, Fallah N, Santos A, Vachon J, Noonan VK, Cheng CL.
Evidence-based planning of rehabilitation interventions is important to improving cost efficiency while maintaining patient and system outcomes. This paper aims to explore the relationship between rehabilitation therapy, functional outcome, bed utilization... (Source: SafetyLit)
Source: SafetyLit - May 19, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Rural and urban living in persons with spinal cord injury and comparing environmental barriers, their health and quality of life outcomes - Glennie RA, Batke J, Fallah N, Cheng CL, Rivers CS, Noonan VK, Dvorak MF, Fisher CG, Kwon BK, Street J.
There is worldwide geographical variation in the epidemiology of traumatic spinal cord injury (tSCI). The aim of this study was to determine whether environment barriers, health status and quality of life outcomes differ between patients with tSCI living i... (Source: SafetyLit)
Source: SafetyLit - May 9, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Does specialized inpatient rehabilitation affect whether or not people with traumatic spinal cord injury return home? - Cheng CL, Plashkes T, Shen T, Fallah N, Humphreys S, O'Connell C, Linassi AG, Ho C, Short C, Ethans K, Charbonneau R, Paquet J, Noonan VK.
Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patie... (Source: SafetyLit)
Source: SafetyLit - May 2, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Brittany Noonan opens up about struggles with body image
Australian fitness blogger and mother-of-one Brittany Noonan, 27, has opened up about a dark moment in her life when she wanted to die because she hated her body. (Source: the Mail online | Health)
Source: the Mail online | Health - May 1, 2017 Category: Consumer Health News Source Type: news
Traumatic spinal cord injury care in Canada: a survey of Canadian centres - Noonan VK, Chan E, Santos A, Soril L, Lewis R, Singh A, Cheng CL, O'Connell C, Truchon C, Paquet J, Christie S, Ethans K, Tsai E, Ford MH, Drew B, Linassi G, Bailey C, Fehlings MG.
The objective of this study was to describe care delivery, with a focus on ... (Source: SafetyLit)
Source: SafetyLit - April 11, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Geomapping of traumatic spinal cord injury in Canada and factors related to triage pattern - Cheng CL, Noonan VK, Shurgold J, Chen J, Rivers CS, Hamedani HK, Humphreys S, Bailey C, Attabib N, Mac-Thiong JM, Goytan M, Paquet J, Fox R, Ahn H, Kwon BK, Fourney DR.
The objectives of this study were to determine the geographic distribution... (Source: SafetyLit)
Source: SafetyLit - March 24, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Methodology of the access to care and timing simulation model for traumatic spinal cord injury care - Santos A, Fallah N, Lewis R, Dvorak MF, Fehlings MG, Burns AS, Noonan VK, Cheng CL, Chan E, Singh A, Belanger LM, Atkins D.
Despite the relatively low incidence, the management and care of persons with traumatic spinal cord injury (tSCI) can be resource intensive and complex, spanning multiple phases of care and disciplines. Using a simulation model built with a system level vi... (Source: SafetyLit)
Source: SafetyLit - March 17, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Noonan Syndrome Diagnosis
Title: Noonan Syndrome DiagnosisCategory: Doctor's& Expert's views on SymptomsCreated: 11/4/2013 12:00:00 AMLast Editorial Review: 3/13/2017 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - March 13, 2017 Category: Pediatrics Source Type: news
Relevance of the international spinal cord injury basic data sets to youth: an Inter-Professional review with recommendations - Carroll A, Vogel LC, Zebracki K, Noonan VK, Biering-S ørensen F, Mulcahey MJ.
STUDY DESIGN: Mixed methods, using the Modified Delphi Technique and Expert Panel Review. OBJECTIVE: To evaluate the utility and relevance of the International Spinal Cord Injury (SCI) Core and Basic Data Sets for children and youth with SCI. SETTI... (Source: SafetyLit)
Source: SafetyLit - March 4, 2017 Category: Global & Universal Tags: Age: Adolescents Source Type: news
Impact of trauma system structure on injury outcomes: a systematic review protocol - Moore L, Champion H, O'Reilly G, Leppaniemi A, Cameron P, Palmer C, Abu-Zidan FM, Gabbe B, Gaarder C, Yanchar N, Stelfox HT, Coimbra R, Kortbeek J, Noonan V, Gunning A, Leenan L, Gordon M, Khajanchi M, Shemilt M, Porgo V, Turgeon AF.
BACKGROUND: Injury represents one of the greatest public health challenges of our time with over 5 million deaths and 100 million people temporarily or permanently disabled every year worldwide. The effectiveness of trauma systems in decreasing injury mort... (Source: SafetyLit)
Source: SafetyLit - January 25, 2017 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
How one pregnant woman fought through antenatal depression and an eating disorder to become a mum
When Gold Coast woman Brittany Noonan found out she was pregnant, she was scared, having suffered from anxiety, depression and an eating disorder in the past. Here she shares her story. (Source: the Mail online | Health)
Source: the Mail online | Health - December 19, 2016 Category: Consumer Health News Source Type: news
Can a cancer drug treat a rare cardiac disease?
About 1 in 2,500 babies born in the United States each year have Noonan syndrome (NS), a genetic disorder that results in severe heart defects, among other symptoms. A gene called PTPN11 causes the condition, for which there is no treatment. To identify a potential target for therapy, a team of Yale researchers studied mouse models of the disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - December 14, 2016 Category: Universities & Medical Training Tags: Yale News Source Type: news
BIDMC: Digital microscope Helping Hearts
Researchers at Harvard University get a better look at heart disease and other ailments with fluorescent microscopy from KEYENCE.The genetic disorder Noonan syndrome (NS) causes a host of problems in humans. Growth and musculoskeletal abnormalities, distinctive facial features, issues with the lymphatic system, bruising and bleeding are all associated characteristics of NS, but the most serious complication is congenital heart disease, which manifests itself through a narrowing of the...This story is related to the following:Vision SystemsVisual Inspection Cameras | (Source: Industrial Newsroom - Health, Medical and Dental Supplies)
Source: Industrial Newsroom - Health, Medical and Dental Supplies - October 26, 2016 Category: Medical Equipment Source Type: news
Technical packages in injury and violence prevention to move evidence into practice: systematic reviews and beyond - Haegerich TM, David-Ferdon C, Noonan RK, Manns BJ, Billie HC.
Injury and violence prevention strategies have greater potential for impact when they are based on scientific evidence. Systematic reviews of the scientific evidence can contribute key information about which policies and programs might have the greatest i... (Source: SafetyLit)
Source: SafetyLit - September 14, 2016 Category: Global & Universal Tags: Commentary Source Type: news
Book Review: When Someone You Know Has Depression
Susan J. Noonan, MD, MPH, starts her new book, When Someone You Know has Depression: Words to Say and Things to Do, with a disturbing scenario: “I just don’t know what to do,” Melinda says. She reaches for her purse and takes out a tissue, dabbing carefully at corners of her eyes. We are sitting in the family room, an alcove barely larger than a closet just outside the psychiatric emergency room. She has come in tonight with her husband who, she has been explain to me, has been slipping farther and farther into a dark depression. “I came home today, and he was sitting at the dining room table with h...
Source: Psych Central - September 10, 2016 Category: Psychiatry Authors: Megan Riddle Tags: Bipolar Book Reviews Caregivers Children and Teens Cognitive-Behavioral Depression Disorders Family General Mindfulness Personal Stories Postpartum Depression Psychology Relationships & Love Self-Help Stress Suicide Treat Source Type: news
Standardization of data for clinical use and research in spinal cord injury - Biering-S ørensen F, Noonan VK.
Increased survival after spinal cord injury (SCI) worldwide has enhanced the need for quality data that can be compared and shared between centers, countries, as well as across research studies, to better understand how best to prevent and treat SCI. Such ... (Source: SafetyLit)
Source: SafetyLit - August 19, 2016 Category: Global & Universal Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Book Review: When Someone You Know Has Depression
We all want to help and support the people we care about in our lives — whether they’re friends, family members, or significant others. After all, they do the same for us. When one of those people is dealing with a mood disorder, however, it’s easy to feel like you’re out of your depth. You might be afraid of saying or doing the wrong thing. You may worry about making the situation worse. In her book, When Someone You Know Has Depression: Words to Say and Things to Do, Susan Noonan offers concrete suggestions for caregivers attempting to support loved ones dealing with depression and bipolar disorde...
Source: Psych Central - July 24, 2016 Category: Psychiatry Authors: Julia Patt Tags: Bipolar Book Reviews Caregivers Depression Disorders Family General Psychology Treatment Bipolar Disorder books on depression Dysthymia helping with depression how to help someone with depression Major Depressive Disorder moo Source Type: news
The hip in ice hockey: a current concepts review - Kuhn AW, Noonan BC, Kelly BT, Larson CM, Bedi A.
Ice hockey is a fast, physical sport with unique associated biomechanical demands often placing the hip in forced and repetitive supraphysiological ranges of motion. Ice hockey players commonly endure and are sidelined by nebulous groin injury or hip pain.... (Source: SafetyLit)
Source: SafetyLit - June 27, 2016 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Harmonization of Databases: a Step for Advancing the Knowledge about Spinal Cord Injury - Charlifue S, Tate D, Biering-Sorensen F, Burns S, Chen Y, Chun S, Jakeman LB, Kowalski RG, Noonan VK, Ullrich P.
The objective of this manuscript is to provide an overview of existing spinal cord injury (SCI) clinical research databases, their purposes, characteristics and accessibility to users, and present a vision for future collaborations required for cross-cutti... (Source: SafetyLit)
Source: SafetyLit - May 7, 2016 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Write, draw, show, and tell: a child-centred dual methodology to explore perceptions of out-of-school physical activity - Noonan RJ, Boddy LM, Fairclough SJ, Knowles ZR.
BACKGROUND: Research to increase children's physical activity and inform intervention design has, to date, largely underrepresented children's voices. Further, research has been limited to singular qualitative methods that overlook children's varied lingui... (Source: SafetyLit)
Source: SafetyLit - April 29, 2016 Category: Global & Universal Tags: Age: Infants and Children Source Type: news
State-level variation in the imprisonment-mortality relationship, 2001−2010 - Wildeman C, Noonan ME, Golinelli D, Carson EA, Emanuel N.
BACKGROUND: Most research on the imprisonment-mortality relationship has focused exclusively on non-Hispanic black males and non-Hispanic white males at the national level in the United States. Objective: To document variation in this relationship acro... (Source: SafetyLit)
Source: SafetyLit - March 2, 2016 Category: Global & Universal Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news
The Prevailing Narrative On Trigger Warnings Is Just Plain Wrong
Despite the media scare stories, trigger warnings are not widely used by college professors across the country, according to a survey released in full on Tuesday. They're not even widely demanded by students. And when they are used, the warnings address both liberal and conservative concerns. The nonscientific survey, conducted by the National Coalition Against Censorship, is the first of its kind to gather data on the actual use of trigger warnings in college classes. The conclusion: While professors are fretting about the possibility, there is "no crisis." Trigger warnings advise rea...
Source: Science - The Huffington Post - December 1, 2015 Category: Science Source Type: news
Suicide prevention for the LGBT community: a policy implementation review - McAllister S, Noonan I.
Preventing Suicide in England identifies increased mental health needs and an increased risk of suicide in the lesbian, gay, bisexual and transgendered (LGBT) community. It promotes interventions and service developments aimed at improving the mental healt... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 21, 2015 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news
Development and validation of a computerized algorithm for International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) - Walden K, Bélanger LM, Biering-Sørensen F, Burns SP, Echeverria E, Kirshblum S, Marino RJ, Noonan VK, Park SE, Reeves RK, Waring W, Dvorak MF.
STUDY DESIGN: Validation study. OBJECTIVES: To describe the development and validation of a computerized application of the international standards for neurological classification of spinal cord injury (ISNCSCI). SETTING: Data from acute and rehabi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 11, 2015 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
FDA clears Eko Devices smartphone-connected stethoscope and app
Berkeley, California-based Eko Devices has received FDA 510(k) clearance for its smartphone-enabled stethoscope, called Eko Core as well as the companion smartphone app. Eko Devices, which describes itself as a “Shazam for heartbeats”, has previously received an investment from two Shazam cofounders, as well as Founder.org, Stanford StartX, former HHS advisor John Noonan. The company has raised at least $2.8 million to date. […] (Source: mobihealthnews)
Source: mobihealthnews - September 2, 2015 Category: Information Technology Authors: Aditi Pai Tags: Government/Regulation Uncategorized Eko Core Eko Devices FDA 510(k) clearance Shazam for heart beats smartphone-connected stethoscope Source Type: news
Film That May Show Amelia Earhart Moments Before Last Flight Revealed
LOS ANGELES (AP) — It was a clear spring day in 1937 when Amelia Earhart, ready to make history by flying around the world, brought her personal photographer to a small Southern California airport to document the journey's beginning. Al Bresnik took dozens of still photos, including a few that have likely been seen by millions. His brother John, who tagged along, made a very dark, grainy 3.5-minute home movie almost nobody saw — until now. The film, "Amelia Earhart's Last Photo Shoot," is being released this month by The Paragon Agency publishing house, along with an 80-page book of the same name th...
Source: Science - The Huffington Post - June 9, 2015 Category: Science Source Type: news
Child maltreatment and adult psychopathology in an Irish context - Fitzhenry M, Harte E, Carr A, Keenleyside M, O'Hanrahan K, White MD, Hayes J, Cahill P, Noonan H, O'Shea H, McCullagh A, McGuinness S, Rodgers C, Whelan N, Sheppard N, Browne S.
One-hundred-ninety-nine adult mental health service users were interviewed with a protocol that included the Childhood Trauma Questionnaire, the Structured Clinical Interviews for Axis I and II DSM-IV disorders, the Global Assessment of Functioning scale, ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - June 5, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news
Mayo Clinic Launches Eight Genetic Testing Panels for Cardiac Disorders
ROCHESTER, Minn. — Mayo Clinic’s launch of eight new next-generation sequencing (NGS) panels is intended to improve the lives of patients and families living with inherited cardiac conditions by aiding in the diagnosis and management of these complex disorders. These disorders include hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, Noonan syndrome, Marfan syndrome, long [...] (Source: Mayo Clinic Rochester News)
Source: Mayo Clinic Rochester News - April 8, 2015 Category: Hospital Management Source Type: news