Effects of Xiaoyaosan on the Hippocampal Gene Expression Profile in Rats Subjected to Chronic Immobilization Stress

Conclusion: XYS may have the ability of resistance to stress, enhancement immunity and promotion nerve cell regeneration by regulating the expression of multiple genes in numerous pathways and repaired the stress-induced impairments in hippocampal structure and function by inducing cytoskeletal reorganization. These results may provide the possible target spots in the treatment of stress in rats with XYS. Introduction Xiaoyaosan (XYS) which was first recorded in the Prescriptions of the Bureau of Taiping People's Welfare Pharmacy contains Radix Bupleuri, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Poria, Radix Angelicae Sinensis, Herba Menthae, Rhizoma Zingiberis Recens, and Radix Glycyrrhizae. The long-term studies of our research group have confirmed that XYS has reliable effectiveness in preventing and curing chronic stress. XYS increases the appetite and weight of stressed rats (1) and improves the learning and memory of stressed rats (2). XYS exerts an obvious anti-depressant effect (3). At early stage, the research group studied multiple brain regions including the central hippocampus, the hypothalamus (1), the amygdala (4), the cortex and the pituitary (5), etc., in stressed rats; in particular, the hippocampus was studies using multiple research methods. XYS increases the levels of the post-synaptic density protein 95 (PSD−95) and synaptophysin (SYP) proteins in the hippocampus (2). XYS also increases the hippocampal expression of ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research