An old drug represents a new hope for treating the toughest cancers
Imipramine, an antidepressant used for more than 60 years, showed anticancer activity in a pilot clinical trial conducted at the Mays Cancer Center at UT Health San Antonio.(PRWeb December 20, 2022)Read the full story at (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - December 20, 2022 Category: Pharmaceuticals Source Type: news

The rise and fall and rise of benzodiazepines: a return of the stigmatized and repressed - Balon R, Starcevic V, Silberman E, Cosci F, Dubovsky S, Fava GA, Nardi AE, Rickels K, Salzman C, Shader RI, Sonino N.
The path of discovery has varied for various psychotropic medications, at times beginning with serendipitous findings by keen observers (e.g., the discovery of imipramine ’s antidepressant properties by Roland Kuhn), followed by more targeted research... (Source: SafetyLit)
Source: SafetyLit - March 16, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

imipramine (Tofranil)
Title: imipramine (Tofranil)Category: MedicationsCreated: 7/23/1998 12:00:00 AMLast Editorial Review: 3/15/2019 12:00:00 AM (Source: MedicineNet Depression General)
Source: MedicineNet Depression General - March 15, 2019 Category: Psychiatry Source Type: news

Tofranil (Imipramine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 18, 2017 Category: Drugs & Pharmacology Source Type: news

Tofranil-PM (Imipramine Pamoate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 18, 2017 Category: Drugs & Pharmacology Source Type: news

Book Review: Ordinarily Well: The Case for Antidepressants
For those in the field of mental health, the debate about the efficacy of pharmaceutical medications has been an enduring and uncertain one, and this debate can sometimes end up complicating treatment, outcomes, and even attitudes toward what it means to be well. In his extraordinary new book, Ordinarily Well: The Case for Antidepressants, Peter D. Kramer delves into this debate, taking a rare and unbiased look at the question: Do antidepressants work? Kramer, the author of the widely popular Listening to Prozac, uses his impressive clarity and insight to study the science that has influenced antidepressants. The question ...
Source: Psych Central - September 6, 2016 Category: Psychiatry Authors: Claire Nana Tags: Book Reviews Clinical Trials Disorders General Medications Policy and Advocacy Psychology Psychotherapy Treatment Antidepressant Antipsychotic Bipolar Disorder books on antidepressant efficacy books on antidepressants books on Source Type: news

Antidepressants Work, But Only For Really Depressed People
The biggest mistake in DSM III was introducing the very broad and heterogeneous category 'Major Depressive Disorder'. This combined under one rubric what had previously been two seperate and quite different presentations: 1) severe, melancholic, delusional, or incapacitating depressions, and 2) reactive to stress, mild, and often transient depressions. The result is that many people get the label Major Depressive Disorder, even though their presentation isn't really 'Major', isn't really 'Depressive', isn't really 'Disorder'. Mild sadness in reaction to stress and disappointment is lumped together with the most severe suff...
Source: Science - The Huffington Post - May 7, 2016 Category: Science Source Type: news

Anti-depressants for teens: A second look
This study highlights the importance of talking to your trusted doctor about the things you hear before just accepting the version of results presented to you. As a doctor, I look forward to more studies that re-examine our current understanding of research data. I hope they will help provide the important information I need to best guide my patients. Related Post:Teen suicide tries increased after FDA toughened…Teens with upbeat friends may have better emotional healthAntidepressants cause minimal weight gainThe placebo effect: Amazing and realHeads up, parents: New study with important information…The post ...
Source: New Harvard Health Information - January 22, 2016 Category: Consumer Health News Authors: Nandini Mani, MD Tags: Anxiety and Depression Behavioral Health Children's Health Parenting antidepressants teens Source Type: news

Rehash of 2001 Study Finds Paroxetine, Imipramine Ineffective, Unsafe for Teens
Both paroxetine and imipramine are ineffective and unsafe for treating adolescents with depression, according to a reanalysis of a 2001 study that was recently published online. (Source: AAFP News)
Source: AAFP News - September 30, 2015 Category: Primary Care Source Type: news

Reanalysis: Paroxetine Ineffective and Harmful for Treating Depression in Adolescents (FREE)
By Kelly Young Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS The antidepressants paroxetine and imipramine are ineffective — and even harmful — for treating major depression in adolescents, according to a reanalysis of study data published in The BMJ.In 2001, researchers published results of the industry-funded Study 329. Briefly, nearly 300 adolescents … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 18, 2015 Category: Primary Care Source Type: news

Antidepressant paroxetine study 'under-reported data on harms'
ConclusionThis study stands as a warning about how supposedly neutral scientific research papers may mislead readers by presenting findings in a certain way.The differences between the independent analysis published in the BMJ and the 2001 research paper are stark. They cannot both be right. The "authors" of the 2001 paper appear to have picked outcome measures to suit their results, in the way they present evidence of effectiveness. It has subsequently come to light that the first draft paper was not actually written by the 22 academics named on the paper, but by a "ghostwriter" paid by GSK.The study ...
Source: NHS News Feed - September 17, 2015 Category: Consumer Health News Tags: Medical practice Medication Mental health Pregnancy/child Source Type: news

Medical News Today: Trial review confirms common antidepressant is 'unsafe and ineffective' for teens
From a reanalysis of original trial data from 2001, researchers find the antidepressant paroxetine and the higher dosage drug imipramine are no better than a placebo. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 17, 2015 Category: Consumer Health News Tags: Depression Source Type: news

Why Depression Is Underreported In Men
By Mary Elizabeth Dallas Depression is often seen as a problem mainly affecting women. Ironically, that’s one of the reasons why the condition is underreported among men, according to Amit Anand, M.D., a professor of medicine at the Cleveland Clinic's Lerner College of Medicine and vice-chair of research at its Center for Behavioral Health. Although women are 70 percent more likely than men to have depression, more than 6 million men in the United States struggle with the condition each year, according to the National Institute of Mental Health. However, several obstacles prevent many of them from seeking treatment, A...
Source: Healthy Living - The Huffington Post - December 27, 2014 Category: Consumer Health News Source Type: news

New Sleep Articles Available from February
This month's articles include some important pieces on children's sleep and related testing. Review how a standard sleep study, called a polysomnogram, differs in children. On a related topic, also find out how multiple sleep latency testing (MSLT) is done in children and why. Consider 10 signs that your child may have a sleep problem. Learn how imipramine may be used to treat bedwetting in children. If you use CPAP to treat your sleep apnea, you may want to know some ways you can talk while wearing your mask. Reflect on some of the most important consequences of insomnia, a condition that plagues millions. Finally, learn ...
Source: About Sleep Disorders - February 23, 2014 Category: Sleep Medicine Source Type: news

Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine - Dean B, Tawadros N, Seo MS, Jeon WJ, Everall I, Scarr E, Gibbons A.
We have attempted to replicate studies showing higher levels of serotonin 2A receptors (HTR2A) in the cortex of people with mood disorders and to determine the effects of treating rats with antidepressant drugs on levels of that receptor. In situ [3H]ketan... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 7, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news