Assessment of Eustachian Tube Functioning following surgical intervention of Oral Submucus Fibrosis by using Tympanometry & Audiometry.
This study was conducted to validate the influence of OSMF and its surgical correction on middle ear function and hearing sensitivity. In this study, 20 patients (40 ears) suffering from biopsy proven OSMF (Group 2 & 3) were tested for Middle ear dysfunction and hearing sensitivity using Tympanometry & Audiometry. On Tympanometry, Type A curve was obtained in 29 ears, Type B curve in 11 ears preoperatively. Immediate postoperatively TYPE A curve was obtained in 27 ears, TYPE B curve in 13 ears. After 1 month and 3 month Type B curve was not obtained in any ear. On Audiometry,28 ears showed normal hearing and 12 ear...
Source: Journal of Oral Biology and Craniofacial Research - November 29, 2019 Category: Dentistry Source Type: research

Mortality due to oral and oropharyngeal cancer in Uruguay from 1997 to 2014
Conclusions: Our study described a high mortality rate for oral and oropharyngeal cancer in Uruguay from 1997 to 2014. According to the country's health department, men, tongue cancer, and oral cavity had higher mortality rates, with some variation. Prevention strategies with control of risk factors and early diagnosis are necessary to improve survival in the Uruguayan population. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - November 29, 2019 Category: Dentistry Source Type: research

Effect of passive ultrasonic activation on microorganisms in primary root canal infection: a randomized clinical trial
Abstract Objective: This clinical study sought to evaluate the effectiveness of passive ultrasonic activation (PUA) in eliminating microorganisms in primary endodontic infection (PEI) after instrumentation of root canals using microbiological culture and checkerboard DNA-DNA hybridization. Methodology: Twenty root canals with PEI and apical periodontitis were selected. The root canals were instrumented and then randomly divided into 2 groups, according to the irrigation method: PUA and conventional needle irrigation (CNI). Microbiological samples were collected before instrumentation (S1), after instrumentation (S2) and af...
Source: Journal of Applied Oral Science - November 29, 2019 Category: Dentistry Source Type: research

Optimization of the coating process of minitablets in two different lab-scale fluid bed systems.
Authors: Szczepanska M, Paduszynski P, Kotlowska H, Sznitowska M Abstract The optimization of the coating process for minitablets is extremely important in fluidized bed systems, and allows knowledge acquisition about the process for modern multiparticulate forms. The coating of minitablets allows the development of modified-release pediatric drugs. In our study, 3-mm minitablets with pantoprazole were coated to obtain an enteric product. The experiments were designed to evaluate the quality of the enteric product by efficiency and quality of film coating. Four process parameters at two levels were examined, and 16...
Source: Drug Development and Industrial Pharmacy - November 29, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

CITRIS-ALI: How statistics were used to obfuscate the true findings
Publication date: December 2019Source: Anaesthesia Critical Care & Pain Medicine, Volume 38, Issue 6Author(s): Paul E. Marik, Didier Payen (Source: Anaesthesia, Critical Care and Pain Medicine)
Source: Anaesthesia, Critical Care and Pain Medicine - November 29, 2019 Category: Anesthesiology Source Type: research

Professionals working in operating rooms: A characterization of biological and chemical risks.
This study aims to characterize the OR of a hospital regarding occupational risks, particularly biological and chemical. It was also sought to verify if professionals' training about occupational risks has some influence on their safety behaviors. METHODS: The research method was based on a Questionnaire applied to the 214 professionals working at the operating rooms of a hospital in northern Portugal. RESULTS: The results revealed the occurrence of 39% (95% CI [29.3%, 50.7%]) of accidents involving biological material, and 12% (95% CI [6.1%, 21.0%]) of accidents involving chemical material. Not all professionals...
Source: Work - November 29, 2019 Category: Occupational Health Authors: Carneiro P, Braga AC, Cabuço R Tags: Work Source Type: research

Can negative ureteroscopy be predicted in ureteral stone treatment?
CONCLUSIONS: In this study, the parameters that significantly predicted negative URS were found to be low BMI, no history of stone surgery, distal localization of the stone, small stone area, longer time between the last imaging procedure and URS, and MET applied for the current stone. These parameters should be considered to avoid negative URS and patients should be informed of the possibility of negative URS prior to operation. PMID: 31793863 [PubMed - as supplied by publisher] (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - November 29, 2019 Category: Urology & Nephrology Authors: Sahin MO, Sen V, Irer B, Yildiz G Tags: Can Urol Assoc J Source Type: research

Clinical behavior and outcome of papillary T1 thyroid cancers: South Korea vs. Turkey vs. Colombia. A cohort study analyzing oncological outcomes.
rk CS Abstract BACKGROUND/PURPOSE: There has not been an international multicentric study to examine the relationship between thyroid cancer clinical outcomes and geographic location for South Korea, Colombia, and Turkey, whereas thyroid cancer is amongst the highest three cancer types seen in South Korea and Turkey. The aim of the study was to assess regional differences of T1 papillary thyroid cancer outcomes in Korea, Turkey and Colombia. METHODS: This is an observational non-randomized study. A total of 2720 patients who have been operated for T1 papillary thyroid cancer between 2011 and 2014 and are on r...
Source: Asian Journal of Surgery - November 29, 2019 Category: Surgery Authors: Ozdemir M, Lee YS, Makay O, Dueñas JP, Yazici B, Akgun A, Icoz G, Akyildiz M, Kim SY, Kim SM, Chang H, Chang HS, Park CS Tags: Asian J Surg Source Type: research

Comparison of the efficacy of two surgical procedures on adenoidal hypertrophy in children.
Abstract OBJECTIVE: The aim of this study was to explore the treatment effects of two surgical procedures, performed with nasal endoscopy, on treating adenoidal hypertrophy in children. METHODS: A total of 100 children diagnosed with adenoidal hypertrophy were treated with curettage combined with microwave thermocoagulation and with low-temperature plasma radiofrequency ablation under nasal endoscopic guidance; 6 months after surgery, the effects on snoring, nasal congestion, hearing loss, and gland residue were retrospectively analyzed. RESULTS: Differences in snoring and hearing loss between the two gr...
Source: Archives de Pediatrie - November 29, 2019 Category: Pediatrics Authors: Huang H, Zhang L, Zhang Q, Zhong J, Fu L, Mou Y Tags: Arch Pediatr Source Type: research

A randomized, double-blind, placebo-controlled phase 1b/2 study of ralimetinib, a p38 MAPK inhibitor, plus gemcitabine and carboplatin versus gemcitabine and carboplatin for women with recurrent platinum-sensitive ovarian cancer.
CONCLUSIONS: Addition of ralimetinib to GC resulted in a modest improvement in PFS. PMID: 31791552 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 29, 2019 Category: Cancer & Oncology Authors: Vergote I, Heitz F, Buderath P, Powell M, Sehouli J, Lee CM, Hamilton A, Fiorica J, Moore KN, Teneriello M, Golden L, Zhang W, Pitou C, Bell R, Campbell R, Farrington DL, Bell-McGuinn K, Wenham RM Tags: Gynecol Oncol Source Type: research

Using Cumulative Load to Explain How Body Mass Index and Daily Walking Relate to Worsening Knee Cartilage Damage Over Two Years: The MOST Study
We examined knee overloading and underloading by defining cumulative load as the joint effects of body mass index (BMI) and daily walking, and examined the relation of cumulative load to worsening cartilage damage over two years.MethodsWe used data from the Multicenter Osteoarthritis Study. BMI and steps/day via accelerometry were measured at the 60 ‐month visit. Cartilage damage on magnetic resonance imaging (MRI) was semi‐quantitatively scored using WORMS at the 60‐month and 84‐month visits; worsening damage was defined as increased WORMS between visits. Risk ratios and 95% confidence intervals (RR[95%CI]) were c...
Source: Arthritis and Rheumatology - November 29, 2019 Category: Rheumatology Authors: Dana Voinier, Tuhina Neogi, Joshua J Stefanik, Ali Guermazi, Frank W Roemer, Louise M Thoma, Hiral Master, Michael C Nevitt, Cora E Lewis, James Torner, Daniel K White Tags: FULL LENGTH Source Type: research

GnRH agonists to sustain the luteal phase in antagonist IVF cycles: a randomized prospective trial.
Abstract BACKGROUND: The addition of a GnRH analogue to the luteal phase in in vitro fertilization programs has been seldom proposed due to the presence of GnRH receptors in the endometrium. The aim of the study was to evaluate the effect of triptorelin addition in short antagonist cycles, compared to cycles where the only supplementation was progesterone. METHODS: The primary objective of this study was the study of the effect of Triptorelin addiction during the luteal phase on the live birth rate. Secondary objectives of efficacy were pregnancy rates and implantation rates, as well as safety in terms of OHS...
Source: Reproductive Biology - November 29, 2019 Category: Reproduction Medicine Authors: Fusi FM, Brigante CM, Zanga L, Mignini Renzini M, Bosisio C, Fadini R Tags: Reprod Biol Endocrinol Source Type: research

Time of day difference in postprandial glucose and insulin responses: Systematic review and meta-analysis of acute postprandial studies.
Abstract Current dietary trends show that humans consume up to 40% of their energy intake during the night. Those who habitually eat during the night are observed to have an increased risk of metabolic conditions such as type-2 diabetes and cardiovascular disease. Increasing evidence suggest that a biological consequence of eating during the night is a larger postprandial glucose response, compared to meals eaten earlier in the day. However, findings from individual acute postprandial studies have been inconsistent, due to variations in protocols. Therefore, this review aimed to systematically summarize findings f...
Source: Chronobiology International - November 29, 2019 Category: Biology Authors: Leung GKW, Huggins CE, Ware RS, Bonham MP Tags: Chronobiol Int Source Type: research

Statistical matching for conservation science.
This article is protected by copyright. All rights reserved. PMID: 31782567 [PubMed - as supplied by publisher] (Source: Conservation Biology)
Source: Conservation Biology - November 29, 2019 Category: Biology Authors: Schleicher J, Eklund J, Barnes M, Geldmann J, Oldekop JA, Jones JPG Tags: Conserv Biol Source Type: research

Decomposition of Electron Ionization Mass Spectra for Space Application using a Monte-Carlo approach.
CONCLUSIONS: By removing the solution degeneracy in the decomposition of mass spectra, the method described herein could significantly increase the scientific retrieval from archived space flight mass spectrometry data, where calibration of the ionization source is no longer an option. PMID: 31783433 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 29, 2019 Category: Chemistry Authors: Gautier T, Serigano J, Bourgalais J, Hörst SM, Trainer MG Tags: Rapid Commun Mass Spectrom Source Type: research

Head and Neck Cancer Risk Prediction Models for the US Population from the INHANCE Consortium.
Boffetta P, Hashibe M Abstract Head and neck cancer (HNC) risk prediction models based on risk factor profiles have not yet been developed. We took advantage of the large database including 14 studies (1981-2010) in the US from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium to develop risk prediction models. Seventy percent of the data were used to develop HNC risk prediction models; the remaining 30% were used to validate the models. We used competing risk models to calculate absolute risks. The predictors included age, sex, education, race/ethnicity, alcohol drinking intensity, cigarett...
Source: Am J Epidemiol - November 29, 2019 Category: Epidemiology Authors: Lee YA, Al-Temimi M, Ying J, Muscat J, Olshan AF, Zevallos JP, Winn DM, Li G, Sturgis EM, Morgenstern H, Zhang ZF, Smith E, Kelsey K, McClean M, Vaughan TL, Lazarus P, Chen C, Schwartz SM, Gillison M, Schantz S, Yu GP, D'Souza G, Gross N, Monroe M, Kim J, Tags: Am J Epidemiol Source Type: research

Evaluation of the Normality Assumption in Meta-analyses.
We present a standardization framework for evaluation of the normality assumption and examine its performance in random-effects meta-analyses with simulation studies and real examples. We use both a formal statistical test and a quantile-quantile plot for visualization. Simulation studies show that our normality test has well-controlled type I error rates and reasonable power. We also illustrate the real-world significance of examining the normality assumption with examples. Investigating the normality assumption can provide valuable information for further analysis or clinical application. We recommend routine examination...
Source: Am J Epidemiol - November 29, 2019 Category: Epidemiology Authors: Wang CC, Lee WC Tags: Am J Epidemiol Source Type: research

Regional variation in endovascular treatment rate and in-hospital mortality of abdominal aortic aneurysms in Germany.
Conclusions: This study reveals variations in use of EVAR and in-hospital mortality for iAAA treatment in Germany. This may imply that selection of treatment might not only be influenced by patient characteristics, but also by regional location. These results need to be taken into account when discussing centralization of AAA treatment in Germany. PMID: 31779536 [PubMed - as supplied by publisher] (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - November 29, 2019 Category: Surgery Authors: Trenner M, Salvermoser M, Reutersberg B, Busch A, Schmid V, Eckstein HH, Kuehnl A Tags: Vasa Source Type: research

[Feeding as a source of conflict between patient and family in palliative care].
ares Insa L Abstract INTRODUCTION: conflicts are part of human relationships. Few studies have looked at the conflicts that food can produce at the end of life, the factors that affect its appearance, and the way to manage them. This knowledge would help healthcare teams to improve the care of these patients and their families. AIM: to analyze the existence of a family conflict linked to food in palliative-care oncological patients, its management, and the influence on their appearance of changes in diet, diet control, need to eat, support, adaptation to disease, and the association of feeding with survival, ...
Source: Nutricion Hospitalaria - November 29, 2019 Category: Nutrition Authors: Chisbert Alapont E, Monleón M, García Salvador I, Llinares Insa L Tags: Nutr Hosp Source Type: research

Video feedback for parental sensitivity and attachment security in children under five years.
CONCLUSIONS: There is moderate-certainty evidence that video feedback may improve sensitivity in parents of children who are at risk for poor attachment outcomes due to a range of difficulties. There is currently only little, very low-certainty evidence regarding the impact of video feedback on attachment security, compared with control: results differed based on the type of measure used, and follow-up was limited in duration. There is no evidence that video feedback has an impact on parental stress or anxiety (low- and very low-certainty evidence, respectively). Further evidence is needed regarding the longer-term impact ...
Source: Cochrane Database of Systematic Reviews - November 29, 2019 Category: General Medicine Authors: O'Hara L, Smith ER, Barlow J, Livingstone N, Herath NI, Wei Y, Spreckelsen TF, Macdonald G Tags: Cochrane Database Syst Rev Source Type: research

Older adults incarcerated in state prison: health and quality of life disparities between age cohorts.
Abstract Objectives: This research sought to describe the physical and psychological health and quality of life among older adult men incarcerated in a state prison and to examine the role of age and historical time between age cohorts.Methods: Survey responses from male respondents incarcerated in a medium-security prison (N = 186) were described using frequencies and descriptive statistics; chi-square and analysis of variance analyses were used to examine differences between age cohorts.Results: The average number of chronic health conditions for the sample was higher than those in similar samples;...
Source: Aging and Mental Health - November 29, 2019 Category: Geriatrics Authors: Prost SG, Archuleta AJ, Golder S Tags: Aging Ment Health Source Type: research

Hemostatic Effect of Tranexamic Acid Combined With Factor VIII Concentrate in Prophylactic Setting in Severe Hemophilia A: a preclinical study.
CONCLUSION: Our results suggest a potential benefit of TXA when used in combination with FVIII in prophylactic setting. PMID: 31782901 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - November 29, 2019 Category: Hematology Authors: Janbain M, Enjolras N, Bordet JC, Bolbos R, Brevet M, Leissinger C, Dargaud Y Tags: J Thromb Haemost Source Type: research

Analysis of related factors of recurrence in horizontal semicircular canal benign paroxysmal positional vertigo: a pilot study.
Conclusions: A weak correlation between RD and abnormal C-test is noted. Presence of RD and abnormal C-test in patients with HSC-BPPV predicts a higher recurrence rate. PMID: 31782327 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - November 29, 2019 Category: ENT & OMF Authors: Ding L, Lin T, Zhou X, Han J, Xu A Tags: Acta Otolaryngol Source Type: research

Tooth loss in aggressive periodontitis: results 25 years after active periodontal therapy in a private practice.
Wang Y Abstract AIM: To assess tooth loss in patients with aggressive periodontitis (AgP) 10-35 years after active periodontal therapy (APT) in a private practice and to detect possible factors influencing tooth loss. MATERIAL AND METHODS: In 100 patients with AgP, tooth loss was recorded over a median follow-up period of 25.5 years after APT, retrospectively. Patient- and tooth-level factors were assessed with a Cox frailty regression model. RESULTS: 227 of 2380 teeth were lost during a median follow-up time of 25.5 years (2.3 ± 3.6 teeth/patient, range 0-17 teeth), resulting in a mean tooth los...
Source: Journal of Clinical Periodontology - November 29, 2019 Category: Dentistry Authors: Bäumer A, Weber D, Staufer S, Pretzl B, Körner G, Wang Y Tags: J Clin Periodontol Source Type: research

Impact of Arterial Hypertension on Doxorubicin-Based Chemotherapy-Induced Subclinical Cardiac Damage in Breast Cancer Patients.
Abstract Advances in oncologic therapies have allowed to achieve better outcomes and longer survival in many patients with breast cancer. Anthracyclines are cytotoxic antibiotics widely used in daily oncology practice. However, anthracyclines cause cardiotoxicity which is a limiting factor of its use. Cumulative dose of anthracyclines is the major cause of induced cardiotoxicity. According to previous clinical trials, the major predisposing high-risk factors for anthracycline-based chemotherapy-induced cardiotoxicity are age, body weight, female gender, radiotherapy, and other diseases such as diabetes and hyperte...
Source: Cardiovascular Toxicology - November 29, 2019 Category: Cardiology Authors: Vaitiekus D, Muckiene G, Vaitiekiene A, Maciuliene D, Vaiciuliene D, Ambrazeviciute G, Sereikaite L, Verikas D, Jurkevicius R, Juozaityte E Tags: Cardiovasc Toxicol Source Type: research

Trends in self-reported psychological distress among college and university students from 2010 to 2018.
, Skogen JC Abstract BACKGROUND: An increase in reported psychological distress, particularly among adolescent girls, is observed across a range of countries. Whether a similar trend exists among students in higher education remains unknown. The aim of the current study was to describe trends in self-reported psychological distress among Norwegian college and university students from 2010 to 2018. METHODS: We employed data from the Students' Health and Wellbeing Study (SHoT), a nationwide survey for higher education in Norway including full-time students aged 18-34. Numbers of participants (participation rate...
Source: Psychological Medicine - November 29, 2019 Category: Psychiatry Authors: Knapstad M, Sivertsen B, Knudsen AK, Smith ORF, Aarø LE, Lønning KJ, Skogen JC Tags: Psychol Med Source Type: research

Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study
ConclusionBoth diclofenac and tramadol are equally effective in controlling pain in AP with similar safety profile. (Source: European Journal of Pain)
Source: European Journal of Pain - November 29, 2019 Category: Anesthesiology Authors: Nadipalli S Kumar, Gaurav Muktesh, Tanvir Samra, Phulen Sharma, Jayanta Samanta, Saroj K Sinha, Narendra Dhaka, Thakur D Yadav, Vikas Gupta, Rakesh Kochhar Tags: ORIGINAL ARTICLE Source Type: research

What does “moderate pain” mean? Subgroups holding different conceptions of rating scales evaluate experimental pain differently
ConclusionsIndividuals ’ conceptions of pain labels differ. These conceptions can be quantified and utilized to improve the analysis of ratings of experimental stimuli. Identifying subgroups with different conceptions of pain descriptions could be used to improve predictions of responses to pain in clinical contexts. (Source: European Journal of Pain)
Source: European Journal of Pain - November 29, 2019 Category: Anesthesiology Authors: S Becker, X Fuchs, K Schakib ‐Ektaban, M Schweiker Tags: ORIGINAL ARTICLE Source Type: research

Whole blood levels of S1PR4 mRNA associated with cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
CONCLUSIONS: The results, which are consistent with findings of previous experimental investigations conducted in animal models, support the role of S1PR4 and its ligand, sphingosine-1-phosphate (S1P), in arterial-associated vasoconstriction, which suggests that S1PR4 could be used as a biomarker for cerebral vasospasm in aSAH patients. PMID: 31783362 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 29, 2019 Category: Neurosurgery Authors: Pulcrano-Nicolas AS, Jacquens A, Proust C, Clarençon F, Perret C, Shotar E, Puybasset L, Le Goff W, Degos V, Trégouët DA, Garnier S Tags: J Neurosurg Source Type: research

Depression prevention in adolescents based on Buddhism and Sufficiency Economy Philosophy
Depression among young adolescents can affect the learning performance and quality of life, and increase suicidal risk. Depression prevention (DP) intervention at the early onset is thus important. The participants were 20 adolescents aged between 10 and 14, 5 parents, and 7 teachers who resided in the same province in northern Thailand. Descriptive statistics were employed for data analysis, while qualitative data from four focus group discussions (FGDs) and 17 in-depth interviews (IDIs) were analyzed through content analysis. (Source: Archives of Psychiatric Nursing)
Source: Archives of Psychiatric Nursing - November 29, 2019 Category: Nursing Authors: K. Thummathai, H. Sethabouppha, C. Chanprasit, D. Lasuka Source Type: research

The chances of hepatic resection curing hepatocellular carcinoma
The popular sense of the word “cure” translates into the analytic concept of statistical cure which occurs when a group of patients returns to having similar mortality to a reference population. Data from 2523 resected patients for hepatocellular carcinoma were used to estimate the probability that resection would offer the same life expectancy as patients with chronic hepatitis – cirrhosis, and general population. The cure model suggests that resection can provide the same life-expectancy of patients with chronic hepatitis – cirrhosis in 26.3% of cases, and the same life-expectancy of general popul...
Source: Journal of Hepatology - November 29, 2019 Category: Gastroenterology Authors: Alessandro Cucchetti, Jianhong Zhong, Sarah Berhane, Hidenori Toyoda, KeQing Shi, Toshifumi Tada, Charing C.N. Chong, Bang-De Xiang, Le-Qun Li, Paul B.S. Lai, Giorgio Ercolani, Vincenzo Mazzaferro, Masatoshi Kudo, Matteo Cescon, Antonio Daniele Pinna, Tak Source Type: research

Efficacy of low radioiodine activity versus intermediate-high activity in the ablation of low-risk differentiated thyroid cancer
AbstractPurposeThe aim of our study was to compare the efficacy of thyroid remnant ablation using low (1.1  GBq) and intermediate-high radioiodine (RAI) activity (1.85–3.7 GBq) in low-risk differentiated thyroid carcinoma (DTC) and to evaluate the staging role of the whole body scan (WBS) in detection extrathyroidal disease.Materials and methodsWe retrospectively included 277 patients who underwent total thyroidectomy and RAI for low-risk DTC and divided them in two groups according to RAI activity at ablation: group 1 (n = 174) treated with low activity (1.1 GBq), and group 2 (n&th...
Source: Endocrine - November 29, 2019 Category: Endocrinology Source Type: research

The Effects of a Fixed Combination of Berberis aristata and Silybum marianum on Dyslipidaemia – A Meta-analysis and Systematic Review
Planta Med DOI: 10.1055/a-1063-1649A fixed combination of Berberis aristata and Silybum marianum (Berberol) has been used by patients with dyslipidaemia. The aim of the present meta-analysis was to systematically evaluate the efficacy and safety of a fixed combination of B. aristata and S. marianum (Berberol) on serum lipid levels compared to placebo in a meta-analysis based on randomised, controlled trials. The meta-analysis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, using the PICO (patients, intervention, comparison, outcome) format, and it was registered i...
Source: Planta Medica - November 29, 2019 Category: Drugs & Pharmacology Authors: T óth, Barbara N émeth, Dávid So ós, Alexandra Hegyi, P éter Pham-Dobor, Gr éta Varga, Orsolya Varga, Vikt ória Kiss, Tivadar Sarl ós, Patrícia Er őss, Bálint Csupor, Dezs ő Tags: Original Papers Source Type: research

Age-dependent hemato- and nephrotoxicity in patients with head and neck cancer receiving chemoradiotherapy with weekly cisplatin
AbstractBackground and purposeIn cases of simultaneous chemoradiotherapy (CRT), early recognition of toxic side effects is important, as drug discontinuation may prevent further injury. It appears favorable to undertake further steps to investigate whether patient subgroups behave differently depending on their toxicity profile.MethodsWe retrospectively analyzed 125 consecutive patients with non-metastasized carcinoma of the head and neck who were treated with CRT (cisplatin 40  mg/m2 weekly) in 2013/2014. Patients were planned to receive six cycles of cisplatin. Statistical analyses were performed using the chi2 test, t...
Source: Strahlentherapie und Onkologie - November 29, 2019 Category: Cancer & Oncology Source Type: research

Phenotypical T Cell Differentiation Analysis: A Diagnostic and Predictive Tool in the Study of Primary Immunodeficiencies
In conclusion, PCA applied to T cell MFC data might help the physician to estimate the severity of specific PID and to diversify the clinical and diagnostic approach of the patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 29, 2019 Category: Allergy & Immunology Source Type: research

Periodontal pathogens and clinical parameters in chronic periodontitis
ConclusionIn this specific population, we found that the best model in predicting the mean pocket depth was microbial dybiosis using the dysbiosis ratio taxa formula. While further studies are needed to assess the validity of these results on the general population, such a dysbiosis ratio could be used in the future to monitor the subgingival microbiota. (Source: Molecular Oral Microbiology)
Source: Molecular Oral Microbiology - November 29, 2019 Category: Microbiology Authors: Emile Boyer, B énédicte Martin, Sandrine Le Gall‐David, Shao Bing Fong, Yves Deugnier, Martine Bonnaure‐Mallet, Vincent Meuric Tags: ORIGINAL ARTICLE Source Type: research

Continuous Inking Affects the Biological and Biochemical Responses of Cuttlefish Sepia pharaonis
This study first verified the characteristics of the cuttlefish ink solution, prepared a standard curve of ink solution concentrations, and fitted the relationship function between the release frequency and the released ink weight. Biological statistics indicated that cuttlefish has the ability to continuously release ink (releasing ∼90% of the ink from the ink sac) and that the individuals adapted well during the recovery period. However, re-releasing ink would result in “overexploitation” and high mortality. Hexokinase (HK), pyruvate kinase (PK), and superoxide dismutase (SOD) activities, as well as malon...
Source: Frontiers in Physiology - November 29, 2019 Category: Physiology Source Type: research

Sensors, Vol. 19, Pages 5264: The Effect of Light Source Line Width on the Spectrum Resolution of Dual-Frequency Coherent Detection Signals
Zhao In this paper, the power spectrum resolution problem of dual-frequency coherent mixing signals is analyzed when the Doppler frequency difference is small. The power spectrum function formula of the four optical coherent mixing signals is obtained using statistical theory and the Wiener–Khinchin theorem. The influence of delay time and light source line width on the power spectrum of dual-frequency coherent signals is analyzed using this formula. The results show that delay time only affects the peak of the power spectrum of the coherent signal. An increase in the line width of the light source br...
Source: Sensors - November 29, 2019 Category: Biotechnology Authors: Ren Sun Zhang Zhao Tags: Article Source Type: research

Sensors, Vol. 19, Pages 5256: PSO-LSSVR Assisted GPS/INS Positioning in Occlusion Region
sheng Satellite signals are easily lost in complex observation environments and high dynamic motion states, and the position and posture errors of pure inertial navigation quickly diverges with time. This paper therefore proposes a scheme of occlusion region navigation based on least squares support vector regression (LSSVR), and particle swarm optimization (PSO), used to seek the global optimal parameters. Firstly, the scheme uses the incremental output of GPS (Global Positioning System) and Inertial Navigation System (INS) when the observation is normal as the training output and the training input sample, and then u...
Source: Sensors - November 29, 2019 Category: Biotechnology Authors: Li Xiaoming Tan Xinglong Zhao Changsheng Tags: Article Source Type: research

Molecules, Vol. 24, Pages 4375: Anti-Inflammatory Derivatives with Dual Mechanism of Action from the Metabolomic Screening of Poincianella pluviosa
arisi G. Soares Daniela A. Chagas-Paula Metabolomics approaches have become fundamental strategies for the analysis of complex mixtures, guiding the isolation of target compounds by focusing on unpublished or promising pharmacological properties. The discovery of novel anti-inflammatory agents is important due to several limitations regarding their potency, efficacy, and adverse effects. Thus, novel anti-inflammatory candidates are essential, aiming to find agents with better mechanisms of action. In this context, extracts from Poincianella pluviosa var. peltophoroides demonstrated significant in vivo anti-inflammato...
Source: Molecules - November 29, 2019 Category: Chemistry Authors: Ol ívia da S. Domingos Bianca G. V. Alc ântara M ário F. C. Santos Tatiane C. S. Maiolini Danielle F. Dias Jo ão L. Baldim Jo ão Henrique G. Lago Marisi G. Soares Daniela A. Chagas-Paula Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 4806: Level of Burden and Health-Related Quality of Life in Caregivers of Palliative Care Patients
The objective of this study was to determine the level of burden endured by these primary family caregivers and to identify the variables that predict it in the caregiving relatives of people who require home-based palliative care. A descriptive-correlational cross-sectional study was conducted. Socio-demographic and clinical data were collected from caregivers through a self-administered questionnaire that included questions from the 12-Item Short Form Health Survey (SF-12), Zarit Caregiver Burden Interview (ZBI), Hospital Anxiety and Depression Scale (HADS), Brief Resilient Coping Scale (BRCS), Post Traumatic Growth Inve...
Source: International Journal of Environmental Research and Public Health - November 29, 2019 Category: Environmental Health Authors: Perpi ñá-Galvañ Orts-Beneito Fern ández-Alcántara Garc ía-Sanjuán Garc ía-Caro Caba ñero-Martínez Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 4795: The Impact of Opium Abuse on Lipid Profile in Patients with Diabetes: A Systematic Review and Meta-Analysis
Conclusion: The findings of this systematic review and meta-analysis have shown that opium abuse significantly decreased total cholesterol (P < 0.05) in patients with diabetes. However, the effect of opium abuse on HDL cholesterol, triglycerides, body mass index (BMI) and LDL cholesterol in these patients were not statistically significant (P > 0.05) compared with the control. This result has public health significance in terms of ensuring the promotion of adequate nutritional intake in patients with diabetes who abuse opium. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - November 29, 2019 Category: Environmental Health Authors: Omorogieva Ojo Xiao-Hua Wang Osarhumwese Osaretin Ojo Jude Ibe Tags: Review Source Type: research

Recurrence of infection and hernia following partial versus complete removal of infected hernia mesh: a systematic review and cohort meta-analysis
AbstractBackgroundThe aim of this systematic review and meta-analysis was to determine whether complete removal of infected hernia mesh (CMR) provides better results as compared to partial removal (PMR).MethodsPubMed, EMBASE, Cochrane Library, and MEDLINE via Ovid were systematically searched for records published from 1980 to 2018 by three independent researchers (GM, GS, and GG). Quality assessment, data extraction and analysis were performed according to the Cochrane Handbook for Systematic Reviews of Interventions. Mantel –Haenszel method with odds ratio and 95% confidence interval (OR (95% CI)) as the measure of...
Source: Hernia - November 29, 2019 Category: Sports Medicine Source Type: research

Relationship between polymorphisms in −572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta‐analysis
ConclusionsThe −572G/C IL‐6 gene polymorphism is associated with the risk of RA. The GG genotype may be the main contributor in increasing susceptibility to RA. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 29, 2019 Category: Rheumatology Authors: Chunfang Zhang, Shuang Jiao, Tianyu Li, Lihua Zhao, Huijun Chen Tags: ORIGINAL ARTICLE Source Type: research

Prevalence and clinical significance of incidental findings on multiparametric prostate MRI
ConclusionIFs not related to prostate cancer may be frequently encountered on multiparametric prostate MRI, and they are significantly more common in patients  >  65 years old. (Source: La Radiologia Medica)
Source: La Radiologia Medica - November 29, 2019 Category: Radiology Source Type: research

Frailty Syndromes in Persons With Cerebrovascular Disease: A Systematic Review and Meta-Analysis
Conclusions: Frailty and prefrailty are common in persons with stroke. These results may have clinical implications, as they identify the need to assess frailty in post-stroke survivors and assess how it may affect prognosis. Better quality, longitudinal research that examines the temporal relationship between stroke and frailty are needed, as well as studies on other types of cerebrovascular disease. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 29, 2019 Category: Neurology Source Type: research

Pharmacokinetic Study of a Soft Gelatin Capsule and a Solid-Supersaturatable SMEDDS Tablet of Dutasteride in Beagle Dogs
ConclusionBased on the results of this study, the development of a tablet dosage form of dutasteride using a solid-supersaturatable SMEDDS should be considered for humans. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - November 29, 2019 Category: Drugs & Pharmacology Source Type: research

Elexacaftor/Ivacaftor/Tezacaftor: First Approval
This article summarizes the milestones in the development of elexacaftor/ivacaftor/tezacaftor leading to this first approval for the treatment of cystic fibrosis in patients aged  ≥ 12 years who have ≥ 1F508del mutation in theCFTR gene. (Source: Drugs)
Source: Drugs - November 29, 2019 Category: Drugs & Pharmacology Source Type: research

Large-Scale Beard Extraction Enhances the Cosmetic Results of Scalp Hair Restoration in Advanced Androgenetic Alopecia in East Asian Men: A Retrospective Study
ConclusionLarge-scale beard extraction, when combined with occipital hair extraction, is a safe and effective treatment to enhance the cosmetic appearance of East Asian men with advanced AGA. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 29, 2019 Category: Dermatology Source Type: research

Cancers, Vol. 11, Pages 1902: PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors
In this study, we show that targeting both nicotinamide phosphoribosyltransferase (NAMPT) and p21-activated kinase 4 (PAK4) could become a synthetic lethal strategy for PNET. The expression of PAK4 and NAMPT was found to be higher in PNET tissue compared to normal cells. PAK4-NAMPT dual RNAi suppressed proliferation of PNET cell lines. Treatment with KPT-9274 (currently in a Phase I trial or analogs, PF3758309 (the PAK4 selective inhibitor) or FK866 (the NAMPT inhibitor)) suppressed the growth of PNET cell lines and synergized with the mammalian target of rapamycin (mTOR) inhibitors everolimus and INK-128. Molecular analys...
Source: Cancers - November 29, 2019 Category: Cancer & Oncology Authors: Gabriel Mpilla Amro Aboukameel Irfana Muqbil Steve Kim Rafic Beydoun Philip A. Philip Ramzi M. Mohammad Mandana Kamgar Vinod Shidham William Senapedis Erkan Baloglu Jing Li Gregory Dyson Yue Xue Bassel El-Rayes Asfar S. Azmi Tags: Article Source Type: research