Local dermal application of a compound lidocaine cream in pain management of cancer wounds.
Authors: Peng L, Zheng HY, Dai Y Abstract The aim of this study was to explore the analgesic effect of local application of compound lidocaine/prilocaine cream on cancer wounds during wound care in order to reduce the amount of morphine intake or completely replace the systemic morphine administration and optimize the protocol for cancer wound pain management. All patients were enrolled with a visual analog scale (VAS) pain score ≥4. Before wound care, 60 patients were randomly divided into 2 groups of 30 each: morphine group (10 mg tablet); topical 5% compound lidocaine cream group (0.2 g/cm2). VAS scores, hear...
Source: Brazilian Journal of Medical and Biological Research - November 14, 2019 Category: Research Tags: Braz J Med Biol Res Source Type: research

A National Survey: Evaluating Current Practice and Risk Assessment in Morcellation Amongst Gynaecologists in the United Kingdom
ConclusionCurrent UK practice does not reflect recommendations from the AAGL or BSGE. Deficiencies were identified in pre-operative evaluation, local governance procedures, and consenting practices regarding use of a power morcellator and risk of occult leiomyosarcoma. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - November 14, 2019 Category: OBGYN Source Type: research

Added Sugars Intake among US Infants and Toddlers
Publication date: Available online 14 November 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Kirsten A. Herrick, Cheryl D. Fryar, Heather C. Hamner, Sohyun Park, Cynthia L. OgdenAbstractBackgroundLimited information is available on added sugars consumption in US infants and toddlers.ObjectivesTo present national estimates of added sugars intake among US infants and toddlers by sociodemographic characteristics, to identify top sources of added sugars, and to examine trends in added sugars intake.DesignCross-sectional analysis of 1 day of 24-hour dietary recall data.Participants/settingA nationally ...
Source: Journal of the Academy of Nutrition and Dietetics - November 14, 2019 Category: Nutrition Source Type: research

The Effect of Laughter Therapy on Anxiety: A Meta-analysis
This meta-analysis was conducted to determine the effect of laughter therapy on anxiety. Randomized controlled clinical trials were reviewed on Google Scholar, PubMed, and ISI Web of Sciences databases. Four randomized controlled trials consisting of 157 participants were included in the meta-analysis. Hedge's g test statistics were used to show the common effect between the laughter therapy and control groups in the meta-analysis. Laughter therapy can decrease anxiety levels (standardized mean difference = −1.144; 95% CI, −1.950 to −0.338). Laughter therapy is an effective complementary method to decreas...
Source: Holistic Nursing Practice - November 14, 2019 Category: Nursing Tags: FEATURES Source Type: research

Combined Baccalaureate/Medical Degree Students Match Into Family Medicine Residencies More Than Similar Peers: A Matched Case-Control Study.
CONCLUSIONS: The University of New Mexico Combined Baccalaureate/Medical Degree students match into family medicine at nearly twice the rate of traditional medical degree students, suggesting that the UNM BA/MD program serves to increase the growth rate of the family medicine workforce. PMID: 31722105 [PubMed - in process] (Source: Family Medicine)
Source: Family Medicine - November 14, 2019 Category: Primary Care Tags: Fam Med Source Type: research

Hospital-acquired Clostridioides difficile infections in Alberta: The validity of laboratory-identified event surveillance versus clinical infection surveillance
ConclusionsUsing a laboratory surveillance method to capture hospital-acquired CDI cases is highly sensitive but not overly specific. Changes to improve the specificity of this method are provided. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - November 14, 2019 Category: Infectious Diseases Source Type: research

Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models
DiscussionDependent on animal model, both histopathological and biochemical end-points differed between sampling sites in the liver. Based on these findings, we recommend that sample site location is highly standardized and properly reported in order to minimize potential sampling variation and to optimize reproducibility and meaningful comparisons of preclinical studies of NAFLD. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Relationship between Religious Support and Major Depressive Episode for Adult Non-Medical Prescription Opioid Users and Non-Users.
Conclusions: Religious support from friends and believing religious beliefs are essential in life appeared to be protective factors against MDE among non-users. Further research is needed to explore protective factors that can effectively address the association between opioid misuse and mental health and be incorporated into health interventions targeting the opioid epidemic. PMID: 31718382 [PubMed - as supplied by publisher] (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - November 14, 2019 Category: Addiction Tags: Subst Use Misuse Source Type: research

Prevalence and correlates of non-tissue prostate cancer diagnosis in the United States
ConclusionsNon-tissue diagnosis of prostate cancer, while rare, is not outside normal clinical practice and is strongly associated with advanced patient age, higher clinical stage, multiple comorbidities, and very high PSA levels. (Source: Journal of Geriatric Oncology)
Source: Journal of Geriatric Oncology - November 14, 2019 Category: Cancer & Oncology Source Type: research

Colombian Physiotherapists' Use of Functional Outcome Measures in Their Practice.
Conclusions: The majority of Colombian physiotherapists surveyed are using outcome measures in their practice, which indicates that they are engaged in evidence-based practice. Study findings may stimulate more sharing of information on patient outcomes among Colombian physiotherapists, promote further research, and contribute to advancing practice in Colombia. PMID: 31719720 [PubMed] (Source: Physiotherapy Canada)
Source: Physiotherapy Canada - November 14, 2019 Category: Physiotherapy Authors: Renteria C, Berg K Tags: Physiother Can Source Type: research

A Comparative Analysis of Physiotherapy for Stress Urinary Incontinence after Open or Robotic-Assisted Radical Prostatectomy.
Conclusions: The self-reported benefits of physiotherapy for SUI symptoms did not differ significantly between the two types of prostatectomy surgery at 2 years post-surgery. PMID: 31719716 [PubMed] (Source: Physiotherapy Canada)
Source: Physiotherapy Canada - November 14, 2019 Category: Physiotherapy Authors: Sehgal A, Baverstock R, Wright I, Frey C, Crump T, Carlson K Tags: Physiother Can Source Type: research

Reliability-based voxel selection
Publication date: Available online 14 November 2019Source: NeuroImageAuthor(s): Leyla Tarhan, Talia KonkleAbstractWhile functional magnetic resonance imaging (fMRI) studies typically measure responses across the whole brain, not all regions are likely to be informative for a given study. Which voxels should be considered? Here we propose a method for voxel selection based on the reliability of the data. This method isolates voxels that respond consistently across imaging runs while maximizing the reliability of multi-voxel patterns across the selected voxels. We estimate that it is suitable for designs with at least 15 con...
Source: NeuroImage - November 14, 2019 Category: Neuroscience Source Type: research

Modeling and Comparison of Two Geomagnetic Storm
Publication date: Available online 12 November 2019Source: Advances in Space ResearchAuthor(s): Samed InyurtAbstractThis paper is on the investigation and comparison of two consecutive geomagnetic storms in the 24th solar cycle. The first storm is a moderate (Dst=-50 nT) storm occurred on 22.04.2017, while the second is an intense (Dst=-125 nT) storm happened on 28.05.2017. The comparison was carried out based on solar wind (Bz, E, P, N, v, T) and zonal geomagnetic indices (Dst, ap, AE). Mathematical analysis is introduced to the reader with a data set of 9 variables obtained from NASA's observations. The descriptive stati...
Source: Advances in Space Research - November 14, 2019 Category: Science Source Type: research

Association Between Canine Impaction and Skeletal Pattern in the Sagittal and Vertical Planes.
Authors: Al Balbeesi HO, Al Kawari HM, Al Tamimi AS, Al Mubarak I, Al Ibrahim KI, Divakar DD Abstract In the present study, the authors evaluated the association of canine impaction with different skeletal discrepancies in two planes of space (sagittal and vertical). Cephalometric and orthopantomographic radiographic images of 45 patients with one or more impacted canines were used in this retrospective study. Five radiographic morphologic parameters-ANB angle, canine angulation, angle between the Frankfort horizontal plane and the mandibular plane (FH-MP), Wits appraisal analysis, and axial inclination of the maxi...
Source: International Journal of Periodontics and Restorative Dentistry - November 14, 2019 Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research

Is Perceived Stigma in Clinical Settings Associated With Poor Health Status Among New York City’s Residents of Color?
Conclusions: We found that perceived stigma in health care settings was a potential barrier to good health. Prior studies have illustrated that negative health outcomes are common for patients who avoid or delay care; thus, the unfortunate conclusion is that even in a diverse, heterogeneous community, stigma persists and may negatively affect well-being. Therefore, eliminating stigma in clinical settings should be a top priority for health care providers and public health professionals seeking to improve health equity. (Source: Medical Care)
Source: Medical Care - November 14, 2019 Category: Health Management Tags: Original Articles Source Type: research

Infectivity of Mycobacterium tuberculosis Genotypes and Outcome of Contact Investigation in Classroom in Guangxi, China.
Conclusion: There was not enough evidence from our data to support that Beijing strains were more infective than non-Beijing strains in TB transmission in school setting. PMID: 31111051 [PubMed - indexed for MEDLINE] (Source: Biomed Res)
Source: Biomed Res - November 14, 2019 Category: Research Authors: Pan D, Palittapongarnpim P, Chaiprasert A, Lin M, Lin D, Long X, Huang L, Qin H, McNeil E, Lan R, Qiu X, Chongsuvivatwong V Tags: Biomed Res Int Source Type: research

Ratios of Food Amounts across Three Portion Size Categories on a Food Frequency Questionnaire in Men and Women
This study was conducted as a cross-sectional design.Participants/settingData were from participants (n=2,360) who completed three 24HDRs and the QFFQ in a calibration study of the Multiethnic Cohort Study in 1994-1997.Main outcome measuresMedian food amounts were calculated from 24HDRs for participants who selected each PS category (A, smallest; B; and C, largest) of items on the QFFQ. A-to-B and C-to-B ratios were computed if reported by five or more people in the 24HDRs: A-to-B ratios for 68 items (men) and 88 items (women); C-to-B ratios for 93 items (men) and 79 items (women).Statistical analyses performedThe t test w...
Source: Journal of the Academy of Nutrition and Dietetics - November 14, 2019 Category: Nutrition Source Type: research

The gut microbiome in epilepsy
In this study, we analyzed and compared the intestinal microbiota composition of patients with idiopathic focal epilepsy (n = 30) and healthy volunteer group (n = 10) by 16s ribosomal DNA sequencing. Proteobacteria phylum was found to be higher in patients with epilepsy (25.4%) than in healthy volunteers group (1.5%). The genera of Campylobacter, Delftia, Haemophilus, Lautropia, Neisseria among Proteobacteria phylum were found to be statistically significantly higher in patients with epilepsy than in healthy volunteers (p 
Source: Microbial Pathogenesis - November 14, 2019 Category: Infectious Diseases Source Type: research

Surgical management of Eagle syndrome: A 17-year experience with open and ransoral robotic styloidectomy
Publication date: Available online 12 November 2019Source: American Journal of OtolaryngologyAuthor(s): Thomas H. Fitzpatrick, Benjamin D. Lovin, Marcus J. Magister, Joshua D. Waltonen, James D. Browne, Christopher A. SullivanAbstractEagle Syndrome (ES) is a rare disorder that can present with symptoms ranging from globus sensation to otalgia that is attributed to an elongated styloid process and/or calcified stylohyoid ligament. No standardized treatment algorithm exists, and although various surgical approaches have been described, data on the use of transoral robotic surgery (TORS) in this population is limited. To inve...
Source: American Journal of Otolaryngology - November 14, 2019 Category: Endocrinology Source Type: research

aQbD as a platform for IVRT method development – A regulatory oriented approach
Publication date: 15 December 2019Source: International Journal of Pharmaceutics, Volume 572Author(s): Margarida Miranda, Alberto A.C.C. Pais, Catarina Cardoso, Carla VitorinoAbstractThe EMA draft guideline on quality and equivalence of topical products and the FDA non-binding product specific guidances release has encouraged the establishment of a regulatory background for in vitro release testing (IVRT). Herein, a novel framework applicable to the development of a discriminatory IVRT method is described, according to analytical quality by design (aQbD) principles. A commercially available diclofenac emulgel formulation w...
Source: International Journal of Pharmaceutics - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Influence of ceramic firing on marginal gap accuracy and metal-ceramic bond strength of 3D-printed Co-Cr frameworks
ConclusionsCeramic firing affected the marginal gap; however, all Co-Cr frameworks had a marginal gap lower than 120 μm, which is reported to be a clinically acceptable limit. Most of the specimens (80%) had a metal-ceramic bond strength value higher than the 25-MPa ISO 9693 requirement. Five of 28 dental laboratory technicians were not able to comply with ceramic firing instructions. (Source: The Journal of Prosthetic Dentistry)
Source: The Journal of Prosthetic Dentistry - November 14, 2019 Category: Dentistry Source Type: research

Effects of massage on vital signs, pain and comfort levels in liver transplant patients
This study aimed to determine the effects of back massage on postoperative vital signs, pain, and comfort levels in liver transplant patients.MethodsA quasi-experimental model with a pretest, a posttest, and a control group was used. The population of the study comprised adult patients who had liver transplantation for the first time. The study sample comprised 84 adult patients who had liver transplantation: 42 experimental (study group) and 42 control group, selected by power analysis and the random sampling method from the population. The data were collected between May and September 2016 using the short-form McGill Pai...
Source: EXPLORE: The Journal of Science and Healing - November 14, 2019 Category: Complementary Medicine Source Type: research

Dual antithrombotic therapy with DOACs after ACS or PCI in Atrial Fibrillation: A meta-analysis of Randomized Controlled Trials
Publication date: Available online 12 November 2019Source: Canadian Journal of CardiologyAuthor(s): Mohammed Shurrab, Asaf Danon, Sami Alnasser, Benedict Glover, Anna Kaoutskaia, Mark Henderson, David Newman, Eugene Crystal, Dennis KoAbstractBackgroundThe choice of antithrombotic therapy for atrial fibrillation (AF) patients who have an acute coronary syndrome (ACS) or have undergone percutaneous coronary intervention (PCI) is challenging. We aimed to assess outcomes between dual antithrombotic therapy with DOACs plus an antiplatelet agent (Dual therapy) in comparison to warfarin plus two antiplatelet agents (Triple therap...
Source: Canadian Journal of Cardiology - November 14, 2019 Category: Cardiology Source Type: research

[Evolving Epidemiology of Home Mechanical Ventilation: A Rapidly Growing Challenge for Patient Care].
CONCLUSIONS:  The rapid development of home mechanical ventilation substantially impacts on the development of the hospital landscape in Germany. The exponential increase of these care-intensive patients is challenging for the health care system and requires a discussion about its limits. PMID: 31715635 [PubMed - in process] (Source: Pneumologie)
Source: Pneumologie - November 14, 2019 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

Electrical modelling of homogeneous and filamentary dielectric barrier discharge at atmospheric pressure
Publication date: Available online 13 November 2019Source: Materials Today: ProceedingsAuthor(s): Abdelhamid Laiadi, Abdellah Chentouf, Youssef LaghmichAbstractAn electrical model of Dielectric Barrier Discharge (DBD) is proposed to model the homogeneous and filamentary discharge. In the first part, for the homogeneous discharge, an equivalent circuit based on the electrical behaviour of DBD is studied. The discharge current and the gap voltage signals are given as a result of model simulation. The analysis of charge transfer has been carried out by means of Lissajous figures, and the dynamic of the discharge is depicted b...
Source: Materials Today: Proceedings - November 14, 2019 Category: Materials Science Source Type: research

Standardised criteria for classifying the International Classification of Activities for Time-use Statistics (ICATUS) activity groups into sleep, sedentary behaviour, and physical activity
Globally, the International Classification of Activities for Time-Use Statistics (ICATUS) is one of the most widely used time-use classifications to identify time spent in various activities. Comprehensive 24-... (Source: International Journal of Behavioral Nutrition and Physical Activity)
Source: International Journal of Behavioral Nutrition and Physical Activity - November 14, 2019 Category: Nutrition Authors: Nucharapon Liangruenrom, Melinda Craike, Dorothea Dumuid, Stuart J. H. Biddle, Catrine Tudor-Locke, Barbara Ainsworth, Chutima Jalayondeja, Theun Pieter van Tienoven, Ugo Lachapelle, Djiwo Weenas, David Berrigan, Timothy Olds and Zeljko Pedisic Tags: Methodology Source Type: research

Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics
Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso& Rubin 2016). Here we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons inDrosophila. NO's effects develop more slowly than those of dopamine and depend on soluble guanylate c...
Source: eLife - November 14, 2019 Category: Biomedical Science Tags: Neuroscience Source Type: research

ADHD desynchronizes brain activity during watching a distracted multi-talker conversation
Publication date: Available online 12 November 2019Source: NeuroImageAuthor(s): Juha Salmi, Mostafa Metwaly, Jussi Tohka, Kimmo Alho, Sami Leppämäki, Pekka Tani, Anniina Koski, Tamara Vanderwal, Matti LaineAbstractIndividuals with attention-deficit/hyperactivity disorder (ADHD) have difficulties navigating dynamic everyday situations that contain multiple sensory inputs that need to either be attended to or ignored. As conventional experimental tasks lack this type of everyday complexity, we administered a film-based multi-talker condition with auditory distractors in the background. ADHD-related aberrant brain r...
Source: NeuroImage - November 14, 2019 Category: Neuroscience Source Type: research

A Novel Statistical Analysis and Autoencoder Driven Intelligent Intrusion Detection Approach
Publication date: Available online 13 November 2019Source: NeurocomputingAuthor(s): Cosimo Ieracitano, Ahsan Adeel, Francesco Carlo Morabito, Amir HussainAbstractIn the current digital era, one of the most critical and challenging issue is ensuring cybersecurity in information technology (IT) infrastructures. Indeed, with the significant improvement of technology, hackers have been developing ever more complex and dangerous malware attacks that make the intrusion recognition a very difficult task. In this context, the existing traditional analytic tools are facing severe challenges to detect and mitigate these threats. In ...
Source: Neurocomputing - November 14, 2019 Category: Neuroscience Source Type: research

The hippocampus as a visual area organized by space and time: A spatiotemporal similarity hypothesis.
Abstract The hippocampus is the canonical memory system in the brain and is not typically considered part of the visual system. Yet, it sits atop the ventral visual stream and has been implicated in certain aspects of vision. Here I review the place of the hippocampal memory system in vision science. After a brief primer on the local circuity, external connectivity, and computational functions of the hippocampus, I explore what can be learned from each field about the other. I first present four areas of vision science (scene perception, imagery, eye movements, attention) that challenge our current understanding o...
Source: Vision Research - November 14, 2019 Category: Opthalmology Authors: Turk-Browne NB Tags: Vision Res Source Type: research

Cardiac Magnetic Resonance Derived Metrics are Predictive of Liver Fibrosis in Fontan Patients.
CONCLUSIONS: TCPC resistance, left pulmonary artery stenosis and increased inferior vena cava flow are positively associated with liver fibrosis after Fontan operation and hold promise as important predictors of hepatic decline. These findings encourage pre-procedural planning and interventional strategies to improve TCPC performance and reduce vessel stenosis. Further investigation is warranted to design the ideal Fontan circulation and optimize flow dynamics to reduce the risk of liver fibrosis. PMID: 31734244 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - November 14, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Trusty PM, Wei ZA, Rychik J, Graham A, Russo PA, Surrey LF, Goldberg DJ, Yoganathan AP, Fogel MA Tags: Ann Thorac Surg Source Type: research

Efficacy and Safety of Twice-daily and Once-daily Olopatadine-Mometasone Combination Nasal Spray for Seasonal Allergic Rhinitis.
Abstract BACKGROUND: GSP301 is an investigational fixed-dose combination nasal spray of olopatadine hydrochloride (antihistamine) and mometasone furoate (corticosteroid). OBJECTIVE: To evaluate efficacy and safety of GSP301 in patients with seasonal AR (SAR). METHODS: In this phase 2, double-blind, parallel-group study, patients (≥12 years of age) with SAR were equally randomized to twice-daily GSP301 (olopatadine 665μg and mometasone 25μg), once-daily GSP301 (olopatadine 665μg and mometasone 50μg), twice-daily or once-daily olopatadine monotherapy (665μg), mometasone monotherapy (twice...
Source: Annals of Allergy, Asthma and Immunology - November 14, 2019 Category: Allergy & Immunology Authors: Andrews CP, Mohar D, Salhi Y, Tantry SK Tags: Ann Allergy Asthma Immunol Source Type: research

Machine learning for target discovery in drug development.
Abstract The discovery of macromolecular targets for bioactive agents is currently a bottleneck for the informed design of chemical probes and drug leads. Typically, activity profiling against genetically manipulated cell lines or chemical proteomics is pursued to shed light on their biology and deconvolute drug-target networks. By taking advantage of the ever-growing wealth of publicly available bioactivity data, learning algorithms now provide an attractive means to generate statistically motivated research hypotheses and thereby prioritize biochemical screens. Here, we highlight recent successes in machine inte...
Source: Current Opinion in Chemical Biology - November 14, 2019 Category: Biochemistry Authors: Rodrigues T, Bernardes GJL Tags: Curr Opin Chem Biol Source Type: research

Direct analysis bromine and iodine of dried serum spots by laser ablation-Inductively coupled plasma mass spectrometry.
CONCLUSIONS: A novel and simple approach for high-throughput screening of bromine and iodine in DSS screening analysis has been established by LA-ICP-MS. Calibration could achieved using aqueous standard solution instead of matrix matching solution. The method allowed analysis of low-volume biological samples without decomposition preparation and decreased the risk of contamination or loss. PMID: 31729085 [PubMed - as supplied by publisher] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - November 14, 2019 Category: Chemistry Authors: He J, Li AF, Han HY, Su S, Zhang P, Zhang EP Tags: Rapid Commun Mass Spectrom Source Type: research

Comparison of serum amylase level between dipeptidyl peptidase-4 inhibitor and GLP-1 analog administration in patients with type 2 diabetes mellitus.
Abstract We monitored serum amylase level in patients with type 2 diabetes mellitus (T2DM) prescribed either dipeptidyl peptidase-4 inhibitor or GLP-1 analog (GLP-1 group) as monotherapy. Patients were treated for a 36-month period. All subjects were non-smoker and did not take any alcoholic beverages. Forty-nine patients were prescribed DPP4is (DPP4i group), and 9 patients were prescribed GLP-1 analogs (GLP-1 group). The median of serum amylase levels in DPP4is group was 73 U/mL and the median of serum amylase levels in GLP-1 analog group was 76. Thus, there was no statistical significance between the two ...
Source: Journal of Health, Population, and Nutrition - November 14, 2019 Category: International Medicine & Public Health Authors: Okada J, Yamada E, Niijima Y, Okada S, Yamada M Tags: J Health Popul Nutr Source Type: research

Five ‐year trend in healthcare access and patient‐reported health outcomes among women veterans
ConclusionFederal policy and Veterans Health Administration expansion have had an impact on improving healthcare access to women Veterans. However, increased healthcare access alone does not translate into improved HRQoL or health outcomes for women Veterans. Future policies should not only focus on increasing healthcare access, but also improving health outcomes, especially HRQoL. The quality of the healthcare accessed must be a focus for future research and policy. (Source: Nursing Forum)
Source: Nursing Forum - November 14, 2019 Category: Nursing Authors: Billie Vance, Khalid Alhussain, Usha Sambamoorthi Tags: ORIGINAL ARTICLE Source Type: research

A randomized comparison of manual pressure versus figure ‐of‐eight suture for hemostasis after cryoballoon ablation for atrial fibrillation
AbstractIntroductionCryoballoon ablation is commonly used to treat atrial fibrillation (AF). Femoral vein hemostasis after cryoballoon ablation for AF is routinely achieved with manual pressure (MP) after reversal of heparin and reassessment of the activated clotting time, or with a figure ‐of‐eight suture (F8). The purpose of this randomized trial was to compare these two techniques for femoral vein hemostasis after cryoballoon ablation for AF in a patient population predominantly on novel anticoagulants (NOAC).Methods and ResultsSeventy consecutive patients who underwent cryoballoon ablation were randomized to either...
Source: Journal of Cardiovascular Electrophysiology - November 14, 2019 Category: Cardiology Authors: Vineet Kumar, Marc Wish, Ganesh Venkataraman, Kevin Bliden, Manila Jindal, Adam Strickberger Tags: ORIGINAL ARTICLE Source Type: research

Enhancement of Purified Human Colon Cancer-Specific Parasporal Toxin from Bacillus thuringiensis-LDC-501.
Abstract Parasporal inclusion protein of Bacillus thuringiensis-LDC-501 (Bt-LDC-501) exhibits selective cytocidal action towards human colon cancer cells. The yield of this parasporal protein was minimum in the normal culture. In order to increase the yield of protein from Bt-LDC-501 various agro-based cost-efficient nutrient sources such as corn steep liquor (CSL), sesame oil cake extract (SOC), groundnut oil cake extract (GOC), neem oil cake extract (NOC), rice bran extract (RB), wheat bran extract (WB), red gram hull extract (RGH), green gram hull extract (GGH), black gram hull extract (BGH), Mysore gram hull e...
Source: Current Microbiology - November 14, 2019 Category: Microbiology Authors: Grace JJ, Ramani G, Shenbagarathai R Tags: Curr Microbiol Source Type: research

Online training improves medical students' ability to recognise when a person is dying: The ORaClES randomised controlled trial.
e P Abstract BACKGROUND: Recognising dying is a key clinical skill for doctors, yet there is little training. AIM: To assess the effectiveness of an online training resource designed to enhance medical students' ability to recognise dying. DESIGN: Online multicentre double-blind randomised controlled trial (NCT03360812). The training resource for the intervention group was developed from a group of expert palliative care doctors' weightings of various signs/symptoms to recognise dying. The control group received no training. SETTING/PARTICIPANTS: Participants were senior UK medical students. They re...
Source: Palliative Medicine - November 14, 2019 Category: Palliative Care Authors: White N, Oostendorp LJ, Tomlinson C, Yardley S, Ricciardi F, Gökalp H, Minton O, Boland JW, Clark B, Harries P, Stone P Tags: Palliat Med Source Type: research

Ancestry Estimation Using Cranial and Postcranial Macromorphoscopic Traits.
The objective of this study was to demonstrate the value of postcranial MMS traits, highlighting a combined cranial/postcranial trait approach to ancestry estimation using quadratic discriminant function and a variety of machine learning classification models including artificial neural networks (aNN), random forest models, and support vector machine. Eight cranial and eleven postcranial MMS traits were collected from the Terry and Bass Skeletal Collections (American Black = 81; American White = 173). Our classification models using cranial and postcranial traits correctly classified 88-92% of the sampl...
Source: Journal of Forensic Sciences - November 14, 2019 Category: Forensic Medicine Authors: Spiros MC, Hefner JT Tags: J Forensic Sci Source Type: research

A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque induced gingivitis.
Abstract AIM: The aim of the present study was to evaluate the effects of a chlorhexidine brush-on gel application on plaque-induced gingivitis. MATERIALS & METHODS: Consecutive patients diagnosed with gingivitis were enrolled. For each patient, full mouth plaque score and gingival index were recorded during the first visit (t0) and after 1 week (t1), 2 weeks (t2) and 3 weeks (t3). Patients were randomly divided into a study group, who received instruction to brush their teeth daily with a chlorhexidine-based gel, and a control group, treated with a placebo gel. The chi-square test was used to compare the...
Source: Current Topics in Medicinal Chemistry - November 14, 2019 Category: Chemistry Authors: Nardi GM, Grassi R, Campus G, Pareti ML, Di Stasio D, Della Vella F Tags: Curr Top Med Chem Source Type: research

Self-perceived evidence-based practice competencies: a survey of faculty and students at a chiropractic institution.
CONCLUSION: This study found variance in the self-perceived EBP skills, utilization, barriers, and facilitators and that these skills are lagging at our doctor of chiropractic program, which does not have a structured EBP program. Faculty members and students identified the importance for EBP. Similar observations have been found at other chiropractic institutions prior to their implementation of a systematic EBP program. Those developing an EBP curriculum might use these findings to better design, implement, and assess a structured program. PMID: 31725326 [PubMed - as supplied by publisher] (Source: The Journal of Ch...
Source: The Journal of Chiropractic Education - November 14, 2019 Category: Complementary Medicine Authors: Odhwani AS, Sarkar PK, Giggleman GF, Holmes MM, Pohlman KA Tags: J Chiropr Educ Source Type: research

Effects of alcohol intoxication goggles (fatal vision goggles) with a concurrent cognitive task on simulated driving performance.
Conclusions: Wearing FVG negatively impacted simulated driving performance. However, effects were isolated to specific performance outcomes and were dependent on complexity of the driving task. Addition of a secondary cognitive task exacerbates the effects of FVG on select driving outcomes (i.e. lane position, SDSP), influences the effect direction on other measures (i.e. distance headway), and has a detrimental effect on reaction time to stimuli embedded in the scenario, that is not observed with FVG alone. Future studies using FVG as a surrogate means to alcohol intoxication should consider these results, informing metho...
Source: Traffic Injury Prevention - November 14, 2019 Category: Accident Prevention Authors: Irwin C, Desbrow B, McCartney D Tags: Traffic Inj Prev Source Type: research

Investigating the effect of personality on left-turn behaviors in various scenarios to understand the dynamics of driving styles.
Conclusions: The driving style is dynamic and influenced by personality and driving conditions. Not only the wrong assessment of driving scenarios may lead to danger, but also the driver's personality characteristics such as self-interest, impulsively, and lack of self-confidence will lead to decision-making mistakes even when the judgment of driving scenarios is correct. PMID: 31725336 [PubMed - as supplied by publisher] (Source: Traffic Injury Prevention)
Source: Traffic Injury Prevention - November 14, 2019 Category: Accident Prevention Authors: Fan X, Pan G, Mao Y, He W Tags: Traffic Inj Prev Source Type: research

[Influence of Local Insufflation of Warm Humidified CO2 on the Wound Surface and Body Core Temperature as well as on Wound Healing in Open Colorectal Surgery].
CONCLUSION: The established measures for prevention of perioperative hypothermia in elective procedures are sufficient. However, the local wound surface temperature is not preserved satisfactorily. Deployment of a device for intraoperative insufflation of W-H-CO2 into open wounds may be suitable for maintaining local normothermia. Further studies are needed to determine the influence of warm and humid CO2 on wound healing. PMID: 31726472 [PubMed - as supplied by publisher] (Source: Zentralblatt fur Chirurgie)
Source: Zentralblatt fur Chirurgie - November 14, 2019 Category: Surgery Authors: Kalev G, Egglseder T, Marquardt C, Schiedeck T Tags: Zentralbl Chir Source Type: research

Post-traumatic enophthalmos secondary to orbital fat atrophy: a volumetric analysis.
Conclusions: In addition to an increase in total orbital volume, orbital fat loss occurs with late post-traumatic enophthalmos due to unrepaired fractures. This suggests correction of bony change alone may be insufficient in some cases, and the use of custom implants may compensate for fat atrophy. PMID: 31726012 [PubMed - as supplied by publisher] (Source: Orbit)
Source: Orbit - November 14, 2019 Category: Opthalmology Authors: Cohen LM, Habib LA, Yoon MK Tags: Orbit Source Type: research

Is Facebook a viable recruitment tool?
CONCLUSION: Successful recruitment strategies must provide access to the population of interest and in sufficient numbers to provide a good representative sample of the population of interest for the study. Facebook provides efficient cost-effective access to target populations. IMPLICATIONS FOR PRACTICE: As communication technology advances, nurse researchers must learn to adapt to the changing avenues of communication to reach potential study participants. Effective recruitment and a good representative sample is the key to reliability, validity and transferability of research findings. PMID: 31724345 [PubMed -...
Source: Nurse Researcher - November 14, 2019 Category: Nursing Authors: Welch TD Tags: Nurse Res Source Type: research

Assessment of the effects of dysphagia therapy in patients in the early post-stroke period: a randomised controlled trial.
CONCLUSIONS: A comprehensive therapy for dysphagia is effective and can reduce serious complications of swallowing disorders in clinical practice. CLINICAL IMPLICATIONS: The results of this study could improve the clinical treatment of dysphagia. PMID: 31724147 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - November 14, 2019 Category: Neurology Authors: Krajczy E, Krajczy M, Luniewski J, Bogacz K, Szczegielniak J Tags: Neurol Neurochir Pol Source Type: research

Influence diagnostics and outlier detection for meta ‐analysis of diagnostic test accuracy
SummaryMeta ‐analyses of diagnostic test accuracy (DTA) studies have been gaining prominence in research in clinical epidemiology and health technology development. In these DTA meta‐analyses, some studies may have markedly different characteristics from the others, and potentially be inappropriate to inclu de. The inclusion of these “outlying” studies might lead to biases, yielding misleading results. In addition, there might be influential studies that have notable impacts on the results. In this article, we propose Bayesian methods for detecting outlying studies and their influence diagnostics i n DTA me...
Source: Research Synthesis Methods - November 14, 2019 Category: Chemistry Authors: Yuki Matsushima, Hisashi Noma, Tomohide Yamada, Toshi A. Furukawa Tags: RESEARCH ARTICLE Source Type: research

No effect of vancomycin powder to prevent infection in primary total knee arthroplasty: a retrospective review of 976 cases
ConclusionIntrawound VP administration doesn ’t change the infection rates in primary TKA. The VP administration for preventing PJI is not recommended in primary TKA.Level of evidenceIII. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 14, 2019 Category: Orthopaedics Source Type: research