Clinical outcomes of endoscopic vs retromandibular approach for the treatment of condylar fractures—a randomized clinical trial
This study, therefore, aims to compare the retromandibular (extraoral) approach and EAORIF for the treatment of condylar fractures.Study DesignA prospective analysis of 32 cases of condylar fractures that reported to the SDM Craniofacial Centre (Dharwad, India) was carried out. Sixteen patients had been treated with the retromandibular (RM) approach, and 16 had undergone EAORIF in the period from 2012–2017. Patients were evaluated for clinical parameters, such as fracture site, displacement, and surgical duration, as well as for functional parameters, such as occlusion, maximum interincisal opening, deviation of mout...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - November 10, 2019 Category: ENT & OMF Source Type: research

Role of wastewater treatment plants on environmental abundance of Antimicrobial Resistance Genes in Chilean rivers.
Abstract BACKGROUND: Point sources such as wastewater treatment plants (WWTPs) commonly discharge their effluent into rivers. Their waste may include antibiotic residues, disinfectants, antibiotic resistant bacteria (ARB), and Antimicrobial Resistance Genes (ARG). There is evidence that ARG can be found in the natural environment, but attribution to specific point sources is lacking. OBJECTIVES: The goal of this study was to assess the release and dissemination of ARG from three WWTPs in southern Chile via two pathways: through the river systems, and through wild birds. METHODS: A longitudinal study was ...
Source: International Journal of Hygiene and Environmental health - November 10, 2019 Category: Environmental Health Authors: Bueno I, Verdugo C, Jimenez-Lopez O, Alvarez PP, Gonzalez-Rocha G, Lima CA, Travis DA, Wass B, Zhang Q, Ishii S, Singer RS Tags: Int J Hyg Environ Health Source Type: research

Population pharmacokinetics of ipilimumab in combination with nivolumab in patients with advanced solid tumors
AbstractIpilimumab is a fully human monoclonal antibody approved for the treatment of melanoma as monotherapy and for the treatment of melanoma, renal cell carcinoma, and colorectal cancer in combination with nivolumab. Ipilimumab time ‐varying clearance (CL) was assessed by a population pharmacokinetics (PPK) model developed using statistically significant covariates identified in a previous PPK analysis plus additional covariates. Data from 3,411 patients who received ipilimumab 0.3–10 mg/kg alone or in combination with niv olumab in 16 clinical trials were analyzed. Ipilimumab CL decreased over time; the ch...
Source: CPT: Pharmacometrics and Systems Pharmacology - November 10, 2019 Category: Drugs & Pharmacology Authors: Kinjal Sanghavi, Jason Zhang, Xiaochen Zhao, Yan Feng, Paul Statkevich, Jennifer Sheng, Amit Roy, Heather E. Vezina Tags: ARTICLE Source Type: research

A hierarchical latent response model for inferences about examinee engagement in terms of guessing and item-level non-response.
Abstract In low-stakes assessments, test performance has few or no consequences for examinees themselves, so that examinees may not be fully engaged when answering the items. Instead of engaging in solution behaviour, disengaged examinees might randomly guess or generate no response at all. When ignored, examinee disengagement poses a severe threat to the validity of results obtained from low-stakes assessments. Statistical modelling approaches in educational measurement have been proposed that account for non-response or for guessing, but do not consider both types of disengaged behaviour simultaneously. We bring...
Source: The British Journal of Mathematical and Statistical Psychology - November 10, 2019 Category: Statistics Authors: Ulitzsch E, von Davier M, Pohl S Tags: Br J Math Stat Psychol Source Type: research

Effect of cycling and functional electrical stimulation with linear and interval patterns of timing on gait parameters in patients after stroke: a randomized clinical trial.
Abstract Objective: Patients in the chronic phase after a stroke are an underrepresented group in the literature. Therefore, the aim of this study was to compare the effects of cycling and functional electrical stimulation with linear versus interval patterns of timing on gait parameters in patients after stroke.Design: A double blinded, parallel, randomized clinical trial.Setting: Neuroscience Institute.Participants: Patients with lower limb disability due to stroke (N = 30) with a stroke onset>6 months and
Source: Disability and Rehabilitation - November 10, 2019 Category: Rehabilitation Authors: Shariat A, Nakhostin Ansari N, Honarpishe R, Moradi V, Hakakzadeh A, Cleland JA, Kordi R Tags: Disabil Rehabil Source Type: research

Population pharmacokinetics of ipilimumab in combination with nivolumab in patients with advanced solid tumors
AbstractIpilimumab is a fully human monoclonal antibody approved for the treatment of melanoma as monotherapy and for the treatment of melanoma, renal cell carcinoma, and colorectal cancer in combination with nivolumab. Ipilimumab time ‐varying clearance (CL) was assessed by a population pharmacokinetics (PPK) model developed using statistically significant covariates identified in a previous PPK analysis plus additional covariates. Data from 3,411 patients who received ipilimumab 0.3–10 mg/kg alone or in combination with niv olumab in 16 clinical trials were analyzed. Ipilimumab CL decreased over time; the ch...
Source: CPT: Pharmacometrics and Systems Pharmacology - November 10, 2019 Category: Drugs & Pharmacology Authors: Kinjal Sanghavi, Jason Zhang, Xiaochen Zhao, Yan Feng, Paul Statkevich, Jennifer Sheng, Amit Roy, Heather E. Vezina Tags: ARTICLE Source Type: research

Review of Prediabetes and Hypertensive Disorders of Pregnancy
Am J Perinatol DOI: 10.1055/s-0039-1698831Obesity and diabetes increase hypertensive disorders of pregnancy (HDP) risk, thus preventive interventions are heavily studied. How pregestational prediabetes and related interventions impact HDP risk is less characterized. Therefore, we searched and reviewed the literature to assess the impact on HDP risk of prediabetes and varied interventions. We identified 297 citations related to pregnancy, prediabetes, and early pregnancy interventions. We also reviewed the references and citations of included articles. We included five studies assessing HDP outcomes in women with first trim...
Source: American Journal of Perinatology - November 10, 2019 Category: Perinatology & Neonatology Authors: Carris, Nicholas W. Nwabuobi, Chinedu K. He, Weiwei Bullers, Krystal Wilson, Rone é E. Louis, Judette M. Magness, Ronald R. Tags: Review Article Source Type: research

Effect of Photobiomodulation on Repairing Pressure Ulcers in Adult and Elderly  Patients: A Systematic Review
Pressure ulcers are highly prevalent among adult and elderly patients where risk factors vary. In addition to guidelines to the conventional treatment, some auxiliary therapies such as photobiomodulation have shown promising results in wound healing. In this systematic review, only 5 papers were selected according to the eligibility criteria of this research. It was observed that PBMT red wavelength, similar to standard care, promoted tissue repair with a reduced lesion area. AbstractEvaluation of photobiomodulation therapy (PBMT) in the treatment of pressure ulcers in adults and the elderly. Systematic review, based on th...
Source: Photochemistry and Photobiology - November 10, 2019 Category: Science Authors: Francislene de Fatima Cordeiro Petz, Jorge Vinicius Cestari F élix, Hellen Roehrs, Franciele Soares Pott, Janislei Giseli Dorociaki Stocco, Rodrigo Labat Marcos, Marineli Joaquim Meier Tags: Research Article Source Type: research

Potential Benefits of Laparoscopic Repair of Duodenal Atresia: Insights from a Retrospective Comparative Study
Conclusion Patients undergoing laparoscopic CDO repair at our institution benefited from shorter time to full enteral feeds, and reduced the need for PN as well as postoperative pain medication. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - November 10, 2019 Category: Surgery Authors: Sidler, Martin Djendov, Florin Curry, Joe I. Blackburn, Simon Giuliani, Stefano Eaton, Simon Mullassery, Dhanya Cross, Kate M. De Coppi, Paolo Tags: Original Article Source Type: research

Sinomenine hydrochloride exerts antitumor outcome in ovarian cancer cells by inhibition of long non-coding RNA HOST2 expression.
Conclusion: Our findings recommended that SH exerted the antitumor effect in ovarian cancer cells by hindering expression of HOST2. PMID: 31701766 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - November 9, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Automated high-throughput tensile testing reveals stochastic process parameter sensitivity
This study seeks to understand how automated high throughput testing can be utilized to understand the variable nature of additively manufactured metals at different print conditions, and to allow for statistically meaningful analysis. This is demonstrated by analyzing how different processing parameters, including laser power, scan velocity, and scan pattern, influence the tensile behavior of additively manufactured stainless steel 316L utilizing a newly developed automated test methodology. Microstructural characterization through computed tomography and electron backscatter diffraction is used to understand some of the ...
Source: Materials Science and Engineering: A - November 9, 2019 Category: Materials Science Source Type: research

Effect of coke rate and basicity on computed tomography-measured pore parameters and effective thermal conductivity of iron ore sinter
This study aimed to compare differences in X-ray computed tomography (XCT) measured pore parameters, and examine relationships between pore parameters and sinter effective thermal conductivity based on actual structure. Nine sinter samples (three coke rates multiply three basicity levels) were carefully prepared from pilot-scale sinter pot tests and scanned by XCT with the resolution ratio of 40 μm. The results demonstrate that higher coke rate and basicity promote melt formation during sintering, transforming sinter from particulate structure to melt-bonded structure. Under the tested conditions, sinter porosity i...
Source: Journal of Materials Research and Technology - November 9, 2019 Category: Materials Science Source Type: research

Bayesian approach and time series dimensionality reduction to LSTM-based model-building for fault diagnosis of a reciprocating compressor
Publication date: Available online 8 November 2019Source: NeurocomputingAuthor(s): Diego Cabrera, Adriana Guamán, Shaohui Zhang, Mariela Cerrada, René-Vinicio Sánchez, Juan Cevallos, Jianyu Long, Chuan LiAbstractReciprocating compression machinery is the primary source of compressed air in the industry. Undiagnosed faults in the machinery’s components produce a high rate of unplanned stoppage of production processes that can even result in catastrophic consequences. Fault diagnosis in reciprocating compressors requires complex and time-consuming feature-extraction processes because typical fault ...
Source: Neurocomputing - November 9, 2019 Category: Neuroscience Source Type: research

Redox state of adipose tissue for patients with gastric cancer and its connection with the body mass index and distance from the tumor
Publication date: Available online 9 November 2019Source: Obesity Research & Clinical PracticeAuthor(s): A.P. Burlaka, I.I. Ganusevich, A.V. Vovk, A.A. Burlaka, M.R. Gafurov, S.N. LukinAbstractExcess body weight has been causally linked to an increased risk of different cancer types, including gastric cancer but the mechanisms underlying this relationship are not well understood. Superoxide generation rate, activity of complex I in electron transport chain of mitochondria, activity of matrix metalloproteinase (MMP-2 and 9) of adipose tissues (AT) of patients with gastric cancer in AT located adjacent to tumor (ATAT) an...
Source: Obesity Research and Clinical Practice - November 9, 2019 Category: Eating Disorders & Weight Management Source Type: research

Predictors of 30-day Mortality in ST-Elevation Myocardial Infarction (STEMI) Patients.
CONCLUSION: There are two new score variables that can be used as predictors of 30-day mortality risks for STEMI patients, i.e. the Killip class and GFR with satisfactory calibration and discrimination rate. PMID: 31699947 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Tadalafil Once a Day for Men with Erectile Dysfunction: Is It Superior than On-Demand Administration?
CONCLUSION: administration of tadalafil OAD leads to a better improvement of EF compared to PRN administration. PMID: 31699953 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - November 9, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

[How do renal function and dilation change after pieloplasty surgery in children?]
Authors: Carrillo-Arroyo I, Tordable-Ojeda C, Cabezalí-Barbancho D, Morante-Valverde R, Gómez-Fraile A Abstract OBJECTIVE: The effects of pyeloplasty on renal function are not fully well defined. Our objective is to determine if renal function and renal dilation change after pyeloplasty and the risk factors that may influence in both parameters. METHODS: Retrospective study of patients who underwent pyeloplasty. The parameters analyzed included: age, differential renal function, renal dilation, infection and complications. We compared ultrasound findings with measurement of the anterior-posterior ...
Source: Archivos Espanoles de Urologia - November 9, 2019 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

[Second-line treatment in recurrent urinary incontinence after the use of mid-urethral tapes. Systematic review and metaanalysis of proportions.]
CONCLUSION: The evidence found shows that there may be superiority of the adjustable tapes versus the mid urethral tapes and other included treatments. However, a comparison to statistically corroborate this difference could not be made. These results should be confirmed with multicenter collaborative randomized clinical trials. PMID: 31697249 [PubMed - in process] (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - November 9, 2019 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

The analgesic efficacy of ultrasound guided unilateral transversus abdominis plane block in the pain management of shock wave lithotripsy.
CONCLUSION: Pain relief during SWL operations is still a challenging issue for many clinicians. Our study demonstrates that, among many other anesthetic/analgesic agents and techniques described, unilateral US guided TAP block and diclofenac combination is a feasible option for pain relief during SWL procedures. PMID: 31697254 [PubMed - in process] (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - November 9, 2019 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Understanding the characteristics of sequence-based single-source DNA profiles
Publication date: Available online 9 November 2019Source: Forensic Science International: GeneticsAuthor(s): Sarah Riman, Hari Iyer, Lisa A. Borsuk, Peter M. ValloneAbstractThe sequencing of STR markers provides additional information present in the underlying sequence variation that is typically masked by traditional fragment-based genotyping. However, the interpretation of STR profiles generated by targeted sequencing methods are susceptible to the same factors encountered in profiles processed through capillary gel electrophoresis. These factors include stochastic variation, noise, stutter artifacts, heterozygote imbala...
Source: Forensic Science International: Genetics - November 9, 2019 Category: Forensic Medicine Source Type: research

Analysis of a DNAmixture case involving Romani reference populations
Publication date: Available online 9 November 2019Source: Forensic Science International: GeneticsAuthor(s): Francesco Dotto, Julia Mortera, Laura Baldassarri, Vincenzo PascaliAbstractHere we present an Italian criminal case that shows how statistical methods can be used to extract information from a series of mixed DNA profiles. The case involves several different individuals and a set of different DNA traces. The case possibly involves persons of interest of a small population of Romani origin. First, a brief description of the case is provided. Secondly, we introduce some heuristic tools that can be used to evaluate the...
Source: Forensic Science International: Genetics - November 9, 2019 Category: Forensic Medicine Source Type: research

Epidemiological investigations of Crimean-Congo haemorrhagic fever virus infection in sheep and goats in Balochistan, Pakistan
Publication date: Available online 9 November 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Khushal Khan Kasi, Miriam Andrada Sas, Carola Sauter-Louis, Felicitas von Arnim, Jörn Martin Gethmann, Ansgar Schulz, Kerstin Wernike, Martin H. Groschup, Franz J. ConrathsAbstractCrimean-Congo haemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by the arbovirus Crimean-Congo haemorrhagic fever virus (CCHFV). Livestock serve as a transient reservoir for CCHFV, but do not show clinical signs. In this cross-sectional study, sheep and goats in Balochistan, Pakistan, were examined to determine the CCHFV seroprev...
Source: Ticks and Tick borne Diseases - November 9, 2019 Category: Zoology Source Type: research

Effect of the nutritional status of Creole goats on the density-dependent prolificacy of Haemonchus contortus
In conclusion, this reduced establishment rate was associated with an increased production of eggs by the female parasites and suggested a phenomenon of density-dependent prolificacy of H. contortus probably inherent to the fitness of the parasite population. (Source: Veterinary Parasitology)
Source: Veterinary Parasitology - November 9, 2019 Category: Veterinary Research Source Type: research

3_D surface stereometry of Ag/DLC nanocomposite prepared by RF-PECVD
In this study, a stereometric analysis of the three-dimensional (3-D) surfaces of the Ag/diamond-like carbon (DLC) nanocomposite films was done. The nanocomposite thin films were fabricated by Radio Frequency Plasma-Enhanced Chemical Vapour Deposition (RF-PECVD). The 3-D surface microtexture was studied by high-resolution Atomic Force Microscopy (AFM) records combined with statistical analyses. More detailed information about surface statistical parameters and topographic features of analyzed samples were performed. The statistical parameters relating to the segmented motifs consistent with ISO 25178-2: 2012 have been gene...
Source: Results in Physics - November 9, 2019 Category: Physics Source Type: research

Unfolding pathway and its identifiability in heterogeneous chains of bistable units
Publication date: Available online 9 November 2019Source: Physics Letters AAuthor(s): Manon Benedito, Stefano GiordanoAbstractWe investigate the behavior of a chain of bistable units with an heterogeneous distribution of energy jumps between the folded and unfolded states. For homogeneous chains, loaded by soft or hard devices, all units at each switching occurrence have the same probability to unfold and it is therefore impossible to identify an unfolding pathway. Conversely, the heterogeneity represents a quenched disorder from the statistical mechanics point of view, and is able to break the symmetry eventually generati...
Source: Physics Letters A - November 9, 2019 Category: Physics Source Type: research

Reasons for Abortion: Religion, Religiosity/Spirituality and Attitudes of Male Secondary School Youth in South Africa
This study focused on the relationship between religion, religiosity/spirituality (R/S), and attitudes of a sample of South African male secondary school youth toward women ’s rights to legal abortion in different situations. We distributed 400 self-administered questionnaires assessing the main variables (attitudes toward reasons for abortion and R/S) to the target sample in six different secondary schools in KwaZulu-Natal, South Africa. The responses of a final sam ple of 327 learners were then analyzed using the Statistical Package for the Social Sciences (SPSS) software. The findings revealed that religion and R/...
Source: Journal of Religion and Health - November 9, 2019 Category: Medical Ethics Source Type: research

Tracing life at the dry limit using phospholipid fatty acids – does sampling matter?
Publication date: Available online 8 November 2019Source: Soil Biology and BiochemistryAuthor(s): Stephanie Kusch, Andrea Jaeschke, Ramona Mörchen, Janet RethemeyerAbstractPhospholipid fatty acids (PLFAs) have been used to trace bacterial life in extremely carbon-poor soils of the hyperarid Atacama Desert. However, the low abundances of bacteria and, thus, PLFAs increases the risk of contamination by exogenous PLFAs. Here, we assess whether field sampling strategies (super-clean, clean, and regular sampling protocols) have an effect on PLFA diversity and abundance in hyperarid Atacama soils or whether laboratory proce...
Source: Soil Biology and Biochemistry - November 9, 2019 Category: Biology Source Type: research

Low concentrations of acetylcarvacrol induce drastic morphological damages in ovaries of surviving Rhipicephalus sanguineus sensu lato ticks (Acari: Ixodidae)
Publication date: Available online 8 November 2019Source: MicronAuthor(s): Isaac Filipe Moreira Konig, Marcos Vinícius Silva de Oliveira, Raquel Romano Palmeira Gonçalves, Ana Paula Peconick, Sérgio Scherrer Thomasi, Luís Adriano Anholeto, José Ribamar Lima-de-Souza, Maria Izabel Camargo-Mathias, Rafael Neodini RemedioAbstractRhipicephalus sanguineus sensu lato (s. l.) ticks are targets of acaricidal treatments due to their great veterinary and medical importance. Acetylcarvacrol stands out as a promising acaricidal substance for its increased biocidal activity and stability. Additionally...
Source: Micron - November 9, 2019 Category: Biology Source Type: research

Consistency and identifiability of the polymorphism-aware phylogenetic models
Publication date: Available online 8 November 2019Source: Journal of Theoretical BiologyAuthor(s): Rui Borges, Carolin KosiolAbstractPolymorphism-aware phylogenetic models (PoMo) constitute an alternative approach for species tree estimation from genome-wide data. PoMo builds on the standard substitution models of DNA evolution but expands the classic alphabet of the four nucleotide bases to include polymorphic states. By doing so, PoMo accounts for ancestral and current intra-population variation, while also accommodating population-level processes ruling the substitution process (e.g. genetic drift, mutations, allelic se...
Source: Journal of Theoretical Biology - November 9, 2019 Category: Biology Source Type: research

Robust extended Kalman filter based state estimation for nonlinear dynamic processes with measurements corrupted by gross errors
Publication date: Available online 9 November 2019Source: Journal of the Taiwan Institute of Chemical EngineersAuthor(s): Guiting Hu, Zhengjiang Zhang, Antonios Armaou, Zhengbing YanAbstractThe quality of on-line measurement data usually cannot meet the demands of practical process monitoring and control due to the influence of measurement noise. Although extended Kalman filter (EKF) is able to improve the quality by reconciling the measurement data to fit the dynamic process model describing nonlinear and Gaussian processes, it rarely considers the presence of different types of gross errors, such as outliers, bias and dr...
Source: Journal of the Taiwan Institute of Chemical Engineers - November 9, 2019 Category: Chemistry Source Type: research

Analysis of spatio-temporal rainfall trends across southern African biomes between 1981 and 2016
In this study, we simultaneously examined spatial and temporal rainfall trends based on the space-time rainfall cube derived from 1981 to 2016 CHIRPS satellite rainfall data. The space time rainfall trend analysis revealed a significant (P 
Source: Physics and Chemistry of the Earth, Parts ABC - November 9, 2019 Category: Science Source Type: research

Row over tactical voting site
Publication date: 9 November 2019Source: New Scientist, Volume 244, Issue 3255Author(s): James BallCampaigners under fire for their statistical model for tactical voting (Source: New Scientist)
Source: New Scientist - November 9, 2019 Category: Science Source Type: research

Image-stitching artefacts and distortion in CCD-based cephalograms and their association with sensor type and head movement: ex vivo study.
CONCLUSION: Sensor type, movement type, distance, and pattern affected presence and severity of image-stitching artefacts and distortion in CCD-based cephalograms. PMID: 31697180 [PubMed - as supplied by publisher] (Source: Dentomaxillofacial Radiology)
Source: Dentomaxillofacial Radiology - November 9, 2019 Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research

Development and Testing of a Brief Play Space Audit Tool.
CONCLUSIONS: This brief instrument allows reliable assessment of playground features and their conditions. The scoring method generates a summary of playground conditions and features, which facilitates comparison of playgrounds. This tool has the potential to assist communities in evaluating their play spaces and identifying where to focus resources for improvements. PMID: 31698335 [PubMed - as supplied by publisher] (Source: Journal of Physical Activity and Health)
Source: Journal of Physical Activity and Health - November 9, 2019 Category: Sports Medicine Tags: J Phys Act Health Source Type: research

Warm-Up With Dynamic Stretching: Positive Effects on Match-Measured Change of Direction Performance in Young Elite Volleyball Players.
Authors: Turki O, Dhahbi W, Padulo J, Khalifa R, Ridène S, Alamri K, Milić M, Gueid S, Chamari K Abstract PURPOSE: To explore the immediate (15-s post-warm-up) and the delayed (after 20 and 40 min of simulated volleyball play) effects of 2 different warm-up protocols-a stretching-free volleyball warm-up (NS) and a warm-up incorporating dynamic stretching (DS)-on subsequent change of direction (COD) performance in young elite volleyball players. METHODS: Sixteen male players (age 16.88 [0.34] y, body mass 75.81 [5.41] kg, body height 1.91 [0.05] m, body mass index 20.84 [1.79] kg...
Source: International Journal of Sports Physiology and Performance - November 9, 2019 Category: Sports Medicine Tags: Int J Sports Physiol Perform Source Type: research

Efficacy of monoclonal anti-tumour necrosis factor- α antibodies in uveitic macular oedema.
Efficacy of monoclonal anti-tumour necrosis factor-α antibodies in uveitic macular oedema. Clin Exp Rheumatol. 2019 Oct 17; Authors: Tosi GM, Vitale A, Rigante D, Sota J, Emmi G, Lopalco G, Guerriero S, Iannone F, Vannozzi L, Bitossi A, Frediani B, Cantarini L, Fabiani C Abstract OBJECTIVES: To assess the efficacy of anti-tumour necrosis factor (TNF)-α agents in the treatment of refractory uveitic macular oedema (UME). METHODS: Patients with refractory UME treated with TNF-α blockers were retrospectively enrolled. Central macular thickness (CMT) was assessed at optical coherence t...
Source: Clinical and Experimental Rheumatology - November 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association of apolipoprotein B/apolipoprotein A1 ratio and cardiovascular events in rheumatoid arthritis: results of the CARMA study.
CONCLUSIONS: No association between ApoB/apoA1 ratio and CVE was found at the baseline visit of patients with RA from the CARMA study. PMID: 31694752 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - November 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Long-term survival of lung transplantation for interstitial lung disease associated with connective tissue diseases: a study of 26 cases from a referral centre.
CONCLUSIONS: Long-term post-transplant survival in Northern Spanish patients with CTD-ILD is reduced compared with IPF. PMID: 31694743 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - November 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The Effects of Space Microgravity on Hip and Knee Cartilage: A New Frontier in Orthopaedics.
CONCLUSIONS: Space and associated microgravity conditions adversely impact articular cartilage as demonstrated in murine and human studies. The pathogenetic process occurs due to the mechanically responsive nature of cartilage, with an increase in cartilage metabolism in microgravity. There remains a marked paucity of literature regarding the gravitational force necessary for adequate cartilage survival and the impact of space-related radiation on cartilage repair. Additionally, further studies should assess pharmacologic interventions, such as recombinant human fibroblast growth factor to stimulate cartilaginous growth. ...
Source: Surgical Technology International - November 9, 2019 Category: Surgery Tags: Surg Technol Int Source Type: research

Different exercises for pregnant women with gestational diabetes: a meta-analysis of randomized controlled trials.
CONCLUSIONS: Different types of exercise have different intervention effects on the outcome of patients with gestational diabetes. However, we do not have enough data to determine whether infants benefit from this exercise, and it is still necessary to conduct large-scale, high-quality and long-term intervention studies for verification. PMID: 31684704 [PubMed - as supplied by publisher] (Source: Journal of Sports Medicine and Physical Fitness)
Source: Journal of Sports Medicine and Physical Fitness - November 9, 2019 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

Ankle and Midfoot Power During Single-Limb Heel Rise in Healthy Adults.
Authors: DiLiberto FE, Nawoczenski DA Abstract Although the midfoot is recognized to have an important role in the successful performance of a single-limb heel rise, healthy heel rise performance remains primarily characterized by ankle function. The purpose of this study was to examine the contribution of midfoot region power to single-limb heel rise in healthy adults. Participants (N = 12) performed 20 single-limb heel rises. An electromagnetic motion capture system and a force plate were used to record 3-segment foot motion and ground reaction forces. Inverse dynamic calculations were performed to obtain ankle a...
Source: Journal of Applied Biomechanics - November 9, 2019 Category: Sports Medicine Tags: J Appl Biomech Source Type: research

Complications of Arthroscopic Versus Open Biceps Tenodesis in the Setting of Arthroscopic Rotator Cuff Repairs: An Analysis of the American Board of Orthopaedic Surgery Database.
Authors: Yeung M, Shin JJ, Lesniak BP, Lin A Abstract INTRODUCTION: The purpose of this study was to compare complication rates between arthroscopic versus open biceps tenodesis in the setting of arthroscopic rotator cuff repair and to determine the effect of fellowship training on complication rates. METHODS: The American Board of Orthopaedic Surgery database was used to identify cases of arthroscopic and open biceps tenodesis in the setting of rotator cuff repair between 2012 and 2016. Surgical, medical, and anesthetic complications, location, fellowship training, surgery year, and patient demographic data we...
Source: The Journal of the American Academy of Orthopaedic Surgeons - November 9, 2019 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Statistical effects of optical parametric noise on signal pulses in a synchronously pumped optical parametric oscillator
We report on an experimental study of the statistical effects of optical parametric noise on the signal pulses in a synchronously pumped ... (Source: Journal of the Optical Society of America B)
Source: Journal of the Optical Society of America B - November 9, 2019 Category: Physics Authors: Keisuke Nagashima Yoshihiro Ochi Ryuji Itakura Source Type: research

Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men.
CONCLUSIONS: GAHT modestly reduces both TFV and FTC plasma concentrations. In TGW taking GAHT, it is unknown if this reduction will impact the HIV protective efficacy of a daily PrEP regimen. However, the combination of an on demand (2 + 1 + 1) PrEP regimen and GAHT may result in concentrations too low for reliable prevention of HIV infection. PMID: 31692269 [PubMed - in process] (Source: Journal of the International AIDS Society)
Source: Journal of the International AIDS Society - November 9, 2019 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

Sparse infomax based on hoyer projection and its application to simulated structural mri and snp data.
SPARSE INFOMAX BASED ON HOYER PROJECTION AND ITS APPLICATION TO SIMULATED STRUCTURAL MRI AND SNP DATA. Proc IEEE Int Symp Biomed Imaging. 2019 Apr;2019:418-421 Authors: Duan K, Silva RF, Chen J, Lin D, Calhoun VD, Liu J Abstract Independent component analysis has been widely applied to brain imaging and genetic data analyses for its ability to identify interpretable latent sources. Nevertheless, leveraging source sparsity in a more granular way may further improve its ability to optimize the solution for certain data types. For this purpose, we propose a sparse infomax algorithm based on nonlinear Hoye...
Source: Proceedings - International Symposium on Biomedical Imaging - November 9, 2019 Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research

Statistical inference on the number of cycles in brain networks.
In this study, we present a new scalable algorithm for enumerating the number of cycles in the network. We show that the number of cycles is monotonically decreasing with respect to the filtration values during graph filtration. We further develop a new statistical inference framework for determining the significance of the number of cycles. The methods are applied in determining if the number of cycles is a statistically significant heritable network feature in the functional human brain network. PMID: 31687091 [PubMed] (Source: Proceedings - International Symposium on Biomedical Imaging)
Source: Proceedings - International Symposium on Biomedical Imaging - November 9, 2019 Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research

Direct aspiration for thrombectomy in ischemic stroke: Impact of dwell time.
CONCLUSION: Although statistical significance was not reached, our retrospective analysis exhibited a strong trend toward modified Thrombolysis in Cerebral Infarction first pass improvement when dwell time was increased from 2 to 5 min. PMID: 31696769 [PubMed - as supplied by publisher] (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - November 9, 2019 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Active Appearance Model Induced Generative Adversarial Network for Controlled Data Augmentation.
Authors: Liu J, Shen C, Liu T, Aguilera N, Tam J Abstract Data augmentation is an important strategy for enlarging training datasets in deep learning-based medical image analysis. This is because large, annotated medical datasets are not only difficult and costly to generate, but also quickly become obsolete due to rapid advances in imaging technology. Image-to-image conditional generative adversarial networks (C-GAN) provide a potential solution for data augmentation. However, annotations used as inputs to C-GAN are typically based only on shape information, which can result in undesirable intensity distributions ...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - November 9, 2019 Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research

Prevalence and risk factors of smell dysfunction - a comparison between five German population-based studies.
CONCLUSION: Four factors, well known to describe population composition, contribute to explain differences in the prevalence of olfactory function between studies when the same test system is used. Our results indicate that comorbidities and educational level should always be considered when test systems based on smell recognition are used in population-based studies. PMID: 31693018 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 9, 2019 Category: ENT & OMF Tags: Rhinology Source Type: research

A web-based adolescent depression support system: feedback and implications for the future.
Authors: Anttila K, Anttila M, Välimäki M Abstract The aim is to describe feedback from the adolescents on their use of a web-based depression support system. Web-based support systems can serve as an alternative to conventional treatment or to complement the current services. Mixed methods were used to approach the topic from multiple perspectives. Feedback was collected from adolescents with symptoms of depression or anxiety. Adolescents (n = 46) responded to a questionnaire after participating on the support system, and 24 adolescents did not provide feedback. The data were analyzed with quan...
Source: Informatics for Health and Social Care - November 9, 2019 Category: Information Technology Tags: Inform Health Soc Care Source Type: research