Statistical Laws of Protein Motion in Neuronal Dendritic Trees
Publication date: 17 November 2020Source: Cell Reports, Volume 33, Issue 7Author(s): Fabio Sartori, Anne-Sophie Hafner, Ali Karimi, Andreas Nold, Yombe Fonkeu, Erin M. Schuman, Tatjana Tchumatchenko (Source: Cell Reports)
Source: Cell Reports - November 18, 2020 Category: Cytology Source Type: research

Gender, age and comorbidities as the main prognostic factors in patients with COVID-19 pneumonia.
Authors: Mi J, Zhong W, Huang C, Zhang W, Tan L, Ding L Abstract The coronavirus disease 2019 (COVID-19) pandemic has spread to almost all countries. The currently reported epidemiological statistics show that age, gender, and type of comorbidities may be high-risk factors for critically ill patients with COVID-19. However, there is no comprehensive analysis of these risk factors. In the present study, we systematically explored the prognostic value of the clinical factors (gender, age and comorbidities) in 189 COVID-19 patients from Wuhan, China. We discovered that the gender, age and comorbidities were tightly as...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Morphine inhibits the promotion of inflammatory microenvironment on chronic tibial cancer pain through the PI3K-Akt-NF- κB pathway.
CONCLUSIONS: Morphine inhibits the promotion of inflammatory microenvironment on chronic tibial cancer pain via the PI3K/Akt/NF-κB pathway, and the regulation of the PI3K/Akt/NF-κB pathway can improve the therapeutic effect of morphine on chronic tibial cancer pain. PMID: 33194078 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Long non-coding RNA NCK1-AS1 promotes the proliferation, migration and invasion of non-small cell lung cancer cells by acting as a ceRNA of miR-137.
In this study, we mainly investigate the potential influence of lncRNA NCK1 antisense RNA 1 (NCK1-AS1) on the progression of non-small cell lung cancer (NSCLC). RT-PCR was performed to determine the expression of NCK1-AS1 and miR-137 in NSCLC specimens and cell lines. The clinical significance of NCK1-AS1 in 148 patients was analyzed statistically. The receiver operating characteristic (ROC) curve was performed to estimate the diagnostic value of NCK1-AS1 and miR-137. Regulatory effects of NCK1-AS1 on proliferative, colony formation abilities, metastasis and apoptosis of SK-MES-1 and H1299 cells were assessed through a ser...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Osteotomies combined with soft tissue procedures for symptomatic flexible flatfoot deformity in children.
This study aims to evaluate the efficacy of osteotomies combined with soft tissue procedures in children with flexible flatfoot aged 9-14 years. METHODS: Twenty-eight children (47 feet) with flexible flatfoot who underwent osteotomy combined with soft tissue surgery between July 2014 and October 2017 were included in this study. The main observational indexes included the American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, Foot and Ankle Outcome Score (FAOS), talo-navicular coverage angle (TNCA), talar-first metatarsal angle (T1MA) on the foot anteroposterior (AP) view, calcaneal pitch angle and Me...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Point-of-care microcirculation evaluated with sidestream dark field technology: agreement and comparison between sublingual and sublabial mucosa.
Authors: Qu J, Lu M, Yan Y, Zhou Q, Li W, Guan J Abstract To investigate whether sublabial mucosa is more suitable for evaluation of microcirculation than commonly used sublingual mucosa in ICU patients, we enrolled 57 adults (47 critically ill patients and 10 volunteers) at convenience from Oct 2018 to Jan 2019. Videomicroscopy images at both sublingual mucosa and sublabial mucosa were acquired at the same time in each enrollee. Qualified images were recorded for later analysis. Four video clips of the same site were comprehensively evaluated to yield one Point Of carE Microcirculation (POEM) score by blinded inve...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

microRNAs carried by exosomes promote epithelial-mesenchymal transition and metastasis of liver cancer cells.
In this study, transforming growth factor-β1 treatment effectively induced epithelial-mesenchymal transition (EMT) of SMMC-7721 cells, and the expression and function of microRNAs (miRNAs) were determined to understand the processes involved in liver cancer metastasis. Nanoparticle tracking analysis and western blotting were performed to identify exosomes. Transwell and MTS assays were used to assess cell migration and proliferation, respectively. Immunofluorescence microscopy was used to identify the metastasis of exosomes in cells. High-throughput sequencing was used to identify mRNAs and miRNAs in cells and exosome...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Evaluation of the clinicopathologic features of diffuse large B cell lymphoma after CD19-targeted CAR T-cell therapy emphasizing the potential diagnostic pitfalls.
This study first described the pathologic features of DLBCL after CD19-targeted CAR T-cell therapy. Familiarity with these histologic features and combinations of medical history and genetic analyses facilitate avoiding misdiagnoses. Multiple biopsies are potentially helpful to estimate the treatment effects or prognosis, and stable alterations to any type of III to V, but not a single given one, may indicate a good prognosis. PMID: 33194070 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

The Role of Gait Speed in Dementia: A Secondary Analysis from the SABE Colombia Study
Conclusion: Dementia was associated with slow GS. This finding provides evidence to include GS as a complementary parameter in the assessment of Colombian elderly adults.Dement Geriatr Cogn Disord (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 18, 2020 Category: Geriatrics Source Type: research

Nonadherence to Antiepileptic Medications and Its Determinants among Epileptic Patients at the University of Gondar Referral Hospital, Gondar, Ethiopia, 2019: An Institutional-Based Cross-Sectional Study.
Conclusions: Prevalence of nonadherence to antiepileptic medications among epileptic patients at the University of Gondar Referral Hospital was found to be high. Hence, giving health information about epilepsy and its management will help to reduce antiepileptic medications' nonadherence. PMID: 33194230 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - November 18, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography.
CONCLUSION: The values of CCT, LDiaangle and Rf obtained via 2 instruments were not clinically interchangeable and the AQD, ATA, LT and Rb have poor agreement affected by accommodation. We can estimate the real lens diameter by subtracting 0.61 ± 0.43mm when the lens diameter can only be simulated with SS-OCT. PMID: 33196325 [PubMed - as supplied by publisher] (Source: Expert Review of Medical Devices)
Source: Expert Review of Medical Devices - November 18, 2020 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Risk of New Vertebral Fracture and Combination Therapy with Zoledronic Acid and Teriparatide in Diabetic Patients after Percutaneous Kyphoplasty.
Conclusions: Combination therapy with zoledronic acid and teriparatide could improve the clinical outcomes, and BMD and had the potential to reduce NVF in diabetic patients following PKP. PMID: 33189105 [PubMed - as supplied by publisher] (Source: Asian Spine Journal)
Source: Asian Spine Journal - November 18, 2020 Category: Orthopaedics Tags: Asian Spine J Source Type: research

Does the Surgical Reduction of High Grade Spondylolisthesis Restore Spino-Pelvic Alignment? An Analysis of 35 Patients.
This study aimed to analyze how the sagittal spinopelvic alignment is influenced by an attempted surgical reduction of the L5-S1 segment in patients with high-grade spondylolisthesis (HGS). Overview of Literature: Conventional treatment strategies stress the importance of achieving fusion across the lumbosacral junction in patients with HGS. The role of reduction in this subset of patients is controversial. Methods: This is a retrospective case series of 35 patients with Meyerding grades III, IV, or V spondylolisthesis who underwent surgical treatment in our institution. Before and after surgery, we took standing l...
Source: Asian Spine Journal - November 18, 2020 Category: Orthopaedics Tags: Asian Spine J Source Type: research

Transtubular Anterior Cervical Foraminotomy for the Treatment of Compressive Cervical Radiculopathy: Surgical Results and Complications in a Consecutive Series of Cases.
Conclusions: ACF is a feasible and low-cost alternative to ACDF in selected patients with cervical radiculopathy. The use of tubular retractors in ACF may confer an added advantage that creates a safe corridor for direct cervical root decompression yet minimizing surrounding soft tissue retraction and avoiding unnecessary bone removal. PMID: 33189103 [PubMed - as supplied by publisher] (Source: Asian Spine Journal)
Source: Asian Spine Journal - November 18, 2020 Category: Orthopaedics Tags: Asian Spine J Source Type: research

The Use of 5-Aminolevulinic Acid to Assist Gross Total Resection of Paediatric Posterior Fossa Tumours
Conclusion: This case series adds to the growing body of evidence demonstrating the safety of 5-ALA in the paediatric population. 5-ALA guided resection was found to be useful in the majority of cases but this did not correlate with GTR status. Ependymomas reliably fluoresce in 90% of cases, and 5-ALA-guided resection should be considered when a preoperative diagnosis of ependymoma is suspected.Pediatr Neurosurg (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - November 18, 2020 Category: Neurosurgery Source Type: research

The systemic immune-inflammation index (SII) is an independent prognostic parameter of survival in patients with invasive vulvar cancer.
Authors: Bartl T, Bekos C, Postl M, Alexander R, Polterauer S, Stefanie A, Richard S Abstract OBJECTIVE: To assess the prognostic value of the systemic immune-inflammation index (SII) in patients with vulvar cancer. METHODS: Data of 130 consecutive patients who underwent primary surgical resection for vulvar cancer at the Medical University of Vienna between 1999 and 2018 was retrospectively analyzed. The SII was defined as platelets × neutrophils/lymphocytes as previously described. Its prognostic value on disease-specific survival (DSS) and overall survival (OS) was evaluated by univariate log-rank test...
Source: Journal of Gynecologic Oncology - November 18, 2020 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

Unravelling the effect of data augmentation transformations in polyp segmentation
ConclusionDespite being infrequently used, pixel-based transformations show a great potential to improve polyp segmentation in CVC-EndoSceneStill. On the other hand, image-based transformations are more suitable for Kvasir-SEG. Problem-based transformations behave similarly in both datasets. Polyp area, brightness and contrast of the dataset have an influence on these differences. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - November 18, 2020 Category: Intensive Care Source Type: research

A statistical analysis for RF-EMF exposure levels in sensitive land use: A novel study in Greek primary and secondary education schools.
CONCLUSION: In conclusion, the exposure level in the locations tested are both below 60% of the highest limit set by ICNIRP (International Commision on Non-Ionizing Radiation Protection) regarding sensitive land use. PMID: 33181972 [PubMed - in process] (Source: Environmental Research)
Source: Environmental Research - November 18, 2020 Category: Environmental Health Authors: Kiouvrekis Y, Manios G, Tsitsia V, Gourzoulidis G, Kappas C Tags: Environ Res Source Type: research

In Regard to Razavian et al
We congratulate Razavian et  al on their thorough and informative 40-year systematic review of radiation-induced pelvic insufficiency fractures (PIF) after irradiation for gynecologic malignancies.1 The authors estimate that after pelvic radiation therapy, the crude incidence of PIF is a noteworthy 9.4% and the 5-year actuari al incidence is 15.3%. Their analysis quantitatively consolidates the data with appropriate statistical models to account for inherent limitations of a meta-analysis. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 18, 2020 Category: Radiology Authors: Shaakir Hasan, Robert H. Press, J. Isabelle Choi, Arpit M. Chhabra, Charles B. Simone Tags: Comment Source Type: research

The Autoimmune Registry Releases First Complete List of Autoimmune Diseases With Prevalence Statistics, Disease Subtypes, and Disease Profiles
(Source: NIEHS - National Institute of Environmental Health Sciences - News)
Source: NIEHS - National Institute of Environmental Health Sciences - News - November 18, 2020 Category: Environmental Health Source Type: research

[ASAP] Statistical Heuristic Wettability Analysis of Randomly Textured Surfaces
LangmuirDOI: 10.1021/acs.langmuir.0c02703 (Source: Langmuir)
Source: Langmuir - November 18, 2020 Category: Chemistry Authors: Md. Arifur Rahman Khandoker and Kevin Golovin Source Type: research

Management of thyroid cancer: results from a German and French patient survey.
CONCLUSION: This large survey showed that despite various guidelines for the management of thyroid cancer, thyroid cancer survivors' experiences are noticeably different between two big European countries. Lack of information and unmet needs are still tasks to be addressed in order to optimize thyroid cancer care. PMID: 33184762 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 18, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Epidemiological Patterns of Skin Disease in Saudi Arabia: A Systematic Review and Meta-Analysis.
Conclusion: Adnexal disorders and dermatitis are the most common skin disease in Saudi Arabia, followed by skin infection and pigmentary disorders. While skin cancer is more frequent than other countries, awareness campaigns should be initiated to increase knowledge about the harmful effect of long-term sun exposure. PMID: 33193756 [PubMed] (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - November 18, 2020 Category: Dermatology Tags: Dermatol Res Pract Source Type: research

Incidence and Risk of PD-1/PD-L1 Inhibitor-associated Pneumonia in Advance Cancer Patients: A Meta-analysis
Conclusion Compared with chemotherapy, the risk of immune-associated pneumonia is higher in PD-1 and PD-L1 inhibitors, and its occurrence risk is high in the ICI group with NSCLC and the first-line treatment with ICI. This paper provides guidance for clinic treatment of terminal cancers and prevention of complications. 
 DOI: 10.3779/j.issn.1009-3419.2020.103.14 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 18, 2020 Category: Cancer & Oncology Source Type: research

Data Mining and Systematic Pharmacology to Reveal the Mechanisms of Traditional Chinese Medicine in Recurrent Respiratory Tract Infections' Treatment.
This study summarized the prescription rule of TCM in the treatment of RRTI, analyzed the mechanism of supplementing deficiency, and provided a new idea for the treatment of RRTI. PMID: 33193802 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 18, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Outcomes of Primary Bidirectional Glenn in Children with Single Ventricle Physiology and Increased Pulmonary Blood Flow.
CONCLUSION: In our experience, we found that primary BDG could be done safely for patients having SV physiology and increased PBF with acceptable short-term outcomes. It might further reduce the morbidity and mortality for those patients by avoiding the risk of initial pulmonary artery banding or aortopulmonary shunts. PMID: 33234193 [PubMed - in process] (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - November 18, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Dohain AM, Mashat MA, Al-Mojaddidi AMA, Abdelmotaleb ME, Mashat AA, Abdelmohsen G, Abdelsalam MH, Al-Ata J, Attia WA, Faden MS, Zaher ZF, Bahaidarah SA, Alkhushi NA, Al-Radi OO, Elassal AA Tags: Heart Surg Forum Source Type: research

Transcriptome profiling reveals an integrated mRNA-lncRNA signature with predictive value for long-term survival in diffuse large B-cell lymphoma.
In conclusion, we successfully developed an integrated mRNA-lncRNA signature to refine the IPI model for predicting long-term survival of patients with DLBCL. PMID: 33221755 [PubMed - as supplied by publisher] (Source: Aging)
Source: Aging - November 18, 2020 Category: Biomedical Science Authors: Gao Q, Li Z, Meng L, Ma J, Xi Y, Wang T Tags: Aging (Albany NY) Source Type: research

An eleven metabolic gene signature-based prognostic model for clear cell renal cell carcinoma.
In this study, we performed bioinformatics and statistical analyses to investigate the prognostic significance of metabolic genes in clear cell renal cell carcinoma (ccRCC) using the transcriptome data of 539 ccRCC and 72 normal renal tissues from TCGA database. We identified 79 upregulated and 45 downregulated (n=124) metabolic genes in ccRCC tissues. Eleven prognostic metabolic genes (NOS1, ALAD, ALDH3B2, ACADM, ITPKA, IMPDH1, SCD5, FADS2, ACHE, CA4, and HK3) were identified by further analysis. We then constructed an 11-metabolic gene signature-based prognostic risk score model and classified ccRCC patients into high- a...
Source: Aging - November 18, 2020 Category: Biomedical Science Authors: Wu Y, Wei X, Feng H, Hu B, Liu B, Luan Y, Ruan Y, Liu X, Liu Z, Wang S, Liu J, Wang T Tags: Aging (Albany NY) Source Type: research

Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus.
CONCLUSION: UP is a complex and multifactorial problem. In patients with UP the high levels of IL-31 indicates a possible role in pathogenesis. IL-13 serum level on the other hand may be related to the severity of itch in these patients. Optimizing dialysis and targeting these cytokines may provide a potential therapeutic option especially in refractory UP. Further studies addressing these cytokines and their levels in response to various treatments may provide additional information on UP. PMID: 33221158 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 18, 2020 Category: Molecular Biology Authors: Oweis AO, Al-Qarqaz F, Bodoor K, Heis L, Alfaqih MA, Almomani R, Obeidat MA, Alshelleh SA Tags: Cytokine Source Type: research

Part-time positions in Caseload Midwifery Group Practice: Impact on satisfaction and quality of care.
CONCLUSION: Part-time caseload midwifery models offered greater flexibility and work-life-balance for staff compared to full-time models and were well received by women. PMID: 33221289 [PubMed - as supplied by publisher] (Source: Women Birth)
Source: Women Birth - November 18, 2020 Category: Midwifery Authors: Vasilevski V, Sweet L, Smith L, Dell M Tags: Women Birth Source Type: research

Optimizing Treatment Sequencing of Chemotherapy for Patients with Rectal Cancer: the KIR Randomized Phase II Trial.
CONCLUSION: We confirmed improved compliance to neoadjuvant CT in this study. Although there is no statistical difference in ypT0N0 rate, local recurrence, and DFS between the two arms, a trend towards favourable oncological outcomes is observed. BACKGROUND: In patients with locally advanced rectal cancer, the standard of care consists of preoperative pelvic external beam radiotherapy (EBRT) followed by total mesorectal excision (TME); EBRT either consists of long course chemoradiotherapy (LCRT) with 5-FU/ Capecitabine or short course hypofractionated radiotherapy (SCRT)(1-6). Oxaliplatin in combination with fluoropyr...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 18, 2020 Category: Radiology Authors: Garant A, Kavan P, Martin AG, Azoulay L, Vendrely V, Lavoie C, Vasilevsky CA, Boutros M, Faria J, Nghia Nguyen T, Ferland E, Des Groseilliers S, Cloutier AS, Diec H, Drolet S, Richard C, Batist G, Vuon T Tags: Radiother Oncol Source Type: research

Learning vocabulary and grammar from cross-situational statistics.
Abstract Across multiple situations, child and adult learners are sensitive to co-occurrences between individual words and their referents in the environment, which provide a means by which the ambiguity of word-world mappings may be resolved (Monaghan & Mattock, 2012; Scott & Fisher, 2012; Smith & Yu, 2008; Yu & Smith, 2007). In three studies, we tested whether cross-situational learning is sufficiently powerful to support simultaneous learning the referents for words from multiple grammatical categories, a more realistic reflection of more complex natural language learning situations. In Experime...
Source: Cognition - November 18, 2020 Category: Neurology Authors: Rebuschat P, Monaghan P, Schoetensack C Tags: Cognition Source Type: research

Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys.
This study evaluated the effects of opicapone as adjunct to levodopa in reversing a 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) induced Parkinson´s-like syndrome in cynomolgus monkeys in during opicapone preclinical development program. A Parkinson´s-like syndrome was induced in cynomolgus monkeys by daily administrations of MPTP. Evaluation of the animals included scoring with the Primate Parkinsonism Motor Rating Scale (PPMRS) and assessment of locomotor activity. MPTP produced a stable Parkinson's-like behavioural syndrome as evidenced by tremor, postural changes, rigidity, impaired movements and ba...
Source: European Journal of Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Authors: Bonifácio MJ, Sousa F, Soares-da-Silva P Tags: Eur J Pharmacol Source Type: research

Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors.
Abstract Fractionated radiation therapy is believed to reoxygenate and subsequently radiosensitize surviving hypoxic cancer cells. Measuring tumor reoxygenation between radiation fractions could conceivably provide an early biomarker of treatment response. However, the relationship between tumor reoxygenation and local control is not well understood. We used noninvasive optical fiber-based diffuse reflectance spectroscopy to monitor radiation-induced changes in hemoglobin oxygen saturation (sO2) in tumor xenografts grown from two head and neck squamous cell carcinoma cell lines - UM-SCC-22B and UM-SCC-47. Tumors w...
Source: Neoplasia - November 18, 2020 Category: Cancer & Oncology Authors: Dadgar S, Troncoso JR, Siegel ER, Curry NM, Griffin RJ, Dings RPM, Rajaram N Tags: Neoplasia Source Type: research

Atherosclerotic Process in Seroreverter Children and Adolescents Exposed to Fetal Antiretroviral Therapy.
CONCLUSION: In utero exposure to the HIV virus and antiretroviral therapy in uninfected children and adolescents is not correlated to accelerated atherosclerosis. PMID: 33213356 [PubMed - as supplied by publisher] (Source: Current HIV Research)
Source: Current HIV Research - November 18, 2020 Category: Infectious Diseases Authors: Martins P, Pires A, Santos JL, Sena C, Seiça R Tags: Curr HIV Res Source Type: research

Long-Term Impact of Diabetes Mellitus on Initially Conservatively Managed Patients With Severe Aortic Stenosis.
T, Yoshikawa Y, Inoko M, Ikeda T, Ishii K, Hotta K, Higashitani N, Kato Y, Inuzuka Y, Maeda C, Jinnai T, Morikami Y, Minatoya K, Kimura T, CURRENT AS Registry Investigators Abstract BACKGROUND: Although diabetes mellitus (DM) is a common comorbidity of aortic stenosis (AS), clinical evidence about the long-term effect of DM on patients with AS is insufficient.Methods and Results:Data were acquired from CURRENT AS, a large Japanese multicenter registry that enrolled 3,815 patients with severe AS. Patients without initial valve replacement were defined as the conservative group; among them, 621 (23.4%) had DM, w...
Source: Circulation Journal - November 18, 2020 Category: Cardiology Authors: Song X, Saito N, Morimoto T, Taniguchi T, Shiomi H, Ando K, Nagao K, Kanamori N, Murata K, Kitai T, Kawase Y, Izumi C, Miyake M, Mitsuoka H, Kato M, Hirano Y, Matsuda S, Inada T, Murakami T, Takeuchi Y, Yamane K, Toyofuku M, Ishii M, Minamino-Muta E, Kato Tags: Circ J Source Type: research

SARS-CoV-2 Clinical Outcomes in Patients with Cancer in a Large Integrated Health Care System in Northern California.
Abstract The SARS-CoV-2 (COVID-19) pandemic continues to affect many lives globally. Patients with cancer undergoing potentially immunosuppressive therapies appear to be at particular risk for the disease and its complications. Here, we describe the experience of patients with cancer within Kaiser Permanente, a large, integrated health system in Northern California. Between February 25, 2020, and June 8, 2020, 4,627 patients were diagnosed with COVID-19, of whom 33 had active cancer treatment within 180 days and 214 had a history of cancer. Patients with active cancer treatment had a statistically higher ri...
Source: The Oncologist - November 18, 2020 Category: Cancer & Oncology Authors: Anantharaman A, Dusendang JR, Schmittdiel JA, Harzstark AL Tags: Oncologist Source Type: research

Artificial Neural Networks for Noise Removal in Data-Sparse Charged Particle Imaging Experiments.
We present the first demonstration of artificial neural networks (ANNs) for the removal of Poissonian noise in charged particle imaging measurements with very low overall counts. The approach is successfully applied to both simulated and real experimental image data relating to the detection of photoions/photoelectrons in unimolecular photochemical dynamics studies. Specific examples consider the multiphoton ionization of pyrrole and (S)-camphor. Our results reveal an extremely high level of performance, with the ANNs transforming images that are unusable for any form of quantitative analysis into statistically reliable da...
Source: Chemphyschem - November 18, 2020 Category: Chemistry Authors: Sparling C, Ruget A, Kotsina N, Leach J, Townsend D Tags: Chemphyschem Source Type: research

The serological responses to acute exercise in humans reduce cancer cell growth in vitro: A systematic review and meta ‐analysis
This systematic review and meta ‐analysis showed that exercise‐conditioned serum significantly reduces in vitro cancer cell growth. This finding provides preliminary evidence that acute exercise‐induced modulations in serum markers may, at least in part, explain the link between regular physical activity and reduced cancer r isk. AbstractWe systematically reviewed and meta ‐analyzed the effects of acute exercise‐conditioned serum on cancer cell growth in vitro. Five literature databases were systematically searched for studies that measured cancer cell growth after exposure to human sera obtained before and immed...
Source: Physiological Reports - November 18, 2020 Category: Physiology Authors: Samuel T. Orange, Alastair R. Jordan, John M. Saxton Tags: REVIEW Source Type: research

Does foreign direct investments impair the ecological footprint? New evidence from the panel quantile regression.
This study examines the impact of foreign direct investments on ecological footprint along with other explanatory variables of 92 countries from the year 2001 to 2016. Here, we applied the panel quantile regression model to meet the purpose of our study as it considers unobserved country heterogeneity, unlike other statistical methods. The study reveals that foreign direct investment has a positive relationship with the ecological footprint in each quantile except one, which proves the constancy of the pollution haven hypothesis. Moreover, we also tried to detect the impact of economic growth, manufacturing value-added, th...
Source: Environmental Science and Pollution Research International - November 18, 2020 Category: Environmental Health Authors: Chowdhury MAF, Shanto PA, Ahmed A, Rumana RH Tags: Environ Sci Pollut Res Int Source Type: research

Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers : A Randomized Controlled Trial.
CONCLUSION: The recommendation to wear surgical masks to supplement other public health measures did not reduce the SARS-CoV-2 infection rate among wearers by more than 50% in a community with modest infection rates, some degree of social distancing, and uncommon general mask use. The data were compatible with lesser degrees of self-protection. PRIMARY FUNDING SOURCE: The Salling Foundations. PMID: 33205991 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - November 18, 2020 Category: Internal Medicine Authors: Bundgaard H, Bundgaard JS, Raaschou-Pedersen DET, von Buchwald C, Todsen T, Norsk JB, Pries-Heje MM, Vissing CR, Nielsen PB, Winsløw UC, Fogh K, Hasselbalch R, Kristensen JH, Ringgaard A, Porsborg Andersen M, Goecke NB, Trebbien R, Skovgaard K, Benfield Tags: Ann Intern Med Source Type: research

Is emotional exhaustion only the result of work experiences? A diary study on daily hassles and uplifts in different life domains.
CONCLUSION: Although the variance in emotional exhaustion that was explained by private events was small, the present study suggests that burnout symptoms might not be completely independent from individuals' daily lives outside work. PMID: 33205664 [PubMed - as supplied by publisher] (Source: Anxiety, Stress, and Coping)
Source: Anxiety, Stress, and Coping - November 18, 2020 Category: Psychiatry & Psychology Authors: Klusmann U, Aldrup K, Schmidt J, Lüdtke O Tags: Anxiety Stress Coping Source Type: research

Influence of age on small incision lenticule extraction outcomes.
CONCLUSIONS: Post-SMILE refractive outcomes in those patients over 40 years of age, although acceptable, are not as good as those obtained in younger patients, showing a significantly lower efficacy and safety indexes, and poorer astigmatic outcomes, with a tendency towards undercorrection. We hypothetise that the increased corneal stroma stiffness in the aged group modifies the post-SMILE corneal stroma remodelling capacity, thus affecting the SMILE refractive and visual response. PMID: 33208352 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - November 18, 2020 Category: Opthalmology Authors: Primavera L, Canto-Cerdan M, Alio JL, Alio Del Barrio JL Tags: Br J Ophthalmol Source Type: research

Serum pentraxin 3 as a biomarker for prognosis of acute minor stroke due to large artery atherosclerosis
Serum pentraxin 3 (PTX3) levels were significantly increased in minor stroke patients. No significant differences in serum PTX3 levels were obtained among stroke subtypes. Serum PTX3 may serve as a predictor for an unfavorable outcome in the Large Artery Atherosclerosis subtype. AbstractObjectivesPentraxin 3 (PTX3) may reflect local inflammatory status in tissues and thus serve as a potential biomarker of inflammation. Here, we investigated the utility of serum PTX3 as an index for assessing the 90 ‐day prognosis of acute minor stroke patients.Materials& MethodsAcute minor stroke patients (N = 241) and matc...
Source: Brain and Behavior - November 18, 2020 Category: Neurology Authors: Yan Zhang, Haijie Hu, Chong Liu, Juan Wu, Shanshan Zhou, Tingting Zhao Tags: ORIGINAL RESEARCH Source Type: research

A whole ‐brain modeling approach to identify individual and group variations in functional connectivity
This paper introduces a modeling approach that regresses whole ‐brain functional connectivity on covariates. Our approach enables the identification of brain subnetworks, which are composite of spatially independent components discovered by a dimension reduction approach (such as whole‐brain group ICA) and covariate‐related projections determined by the c ovariate‐assisted principal regression, a recently introduced covariance matrix regression method. Applying to the Human Connectome Project data, the results show that the approach enjoys improved statistical power in detecting interaction effects of sex and alcoh...
Source: Brain and Behavior - November 18, 2020 Category: Neurology Authors: Yi Zhao, Brian S. Caffo, Bingkai Wang, Chiang ‐Shan R. Li, Xi Luo Tags: Original Research Source Type: research

The serological responses to acute exercise in humans reduce cancer cell growth in vitro: A systematic review and meta ‐analysis
This systematic review and meta ‐analysis showed that exercise‐conditioned serum significantly reduces in vitro cancer cell growth. This finding provides preliminary evidence that acute exercise‐induced modulations in serum markers may, at least in part, explain the link between regular physical activity and reduced cancer r isk. AbstractWe systematically reviewed and meta ‐analyzed the effects of acute exercise‐conditioned serum on cancer cell growth in vitro. Five literature databases were systematically searched for studies that measured cancer cell growth after exposure to human sera obtained before and immed...
Source: Physiological Reports - November 18, 2020 Category: Physiology Authors: Samuel T. Orange, Alastair R. Jordan, John M. Saxton Tags: REVIEW Source Type: research

Serum pentraxin 3 as a biomarker for prognosis of acute minor stroke due to large artery atherosclerosis
Serum pentraxin 3 (PTX3) levels were significantly increased in minor stroke patients. No significant differences in serum PTX3 levels were obtained among stroke subtypes. Serum PTX3 may serve as a predictor for an unfavorable outcome in the Large Artery Atherosclerosis subtype. AbstractObjectivesPentraxin 3 (PTX3) may reflect local inflammatory status in tissues and thus serve as a potential biomarker of inflammation. Here, we investigated the utility of serum PTX3 as an index for assessing the 90 ‐day prognosis of acute minor stroke patients.Materials& MethodsAcute minor stroke patients (N = 241) and matc...
Source: Brain and Behavior - November 18, 2020 Category: Neurology Authors: Yan Zhang, Haijie Hu, Chong Liu, Juan Wu, Shanshan Zhou, Tingting Zhao Tags: ORIGINAL RESEARCH Source Type: research

A whole ‐brain modeling approach to identify individual and group variations in functional connectivity
This paper introduces a modeling approach that regresses whole ‐brain functional connectivity on covariates. Our approach enables the identification of brain subnetworks, which are composite of spatially independent components discovered by a dimension reduction approach (such as whole‐brain group ICA) and covariate‐related projections determined by the c ovariate‐assisted principal regression, a recently introduced covariance matrix regression method. Applying to the Human Connectome Project data, the results show that the approach enjoys improved statistical power in detecting interaction effects of sex and alcoh...
Source: Brain and Behavior - November 18, 2020 Category: Neurology Authors: Yi Zhao, Brian S. Caffo, Bingkai Wang, Chiang ‐Shan R. Li, Xi Luo Tags: Original Research Source Type: research

Evaluation of spatio-temporal variations in water quality and suitability of an ecologically critical urban river employing water quality index and multivariate statistical approaches: A study on Shitalakhya river, Bangladesh
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Source: Human and Ecological Risk Assessment - November 18, 2020 Category: Environmental Health Authors: Md. Humayun Kabir Tanmoy Roy Tusher Md. Saddam Hossain Md. Sirajul Islam Rifat Shahid Shammi Tapos Kormoker Ram Proshad Maksudul Islam Source Type: research

Comment on: Allogenic Simple Limbal Epithelial Transplantation Versus Amniotic Membrane Grafting in the Early Management of Severe-Grade Ocular Chemical Injuries —A Retrospective Comparative Study
We have read with great interest the paper by Agarwal and associates.1 We agree that the establishment of an adequate approach and management of the acute stage of severe ocular chemical injuries is crucial for ensuring the best possible prognosis for these patients. Because of the nature of this disease, it would be extremely difficult to perform a randomized controlled trial to confirm the results perceived by this recently described technique. The findings and conclusions of their study are very interesting, and we would like to comment on the study design and statistical analysis performed. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - November 18, 2020 Category: Opthalmology Authors: Pedro-Ivan Navarro, Alejandro Lichtinger, Jos é Bareño Tags: Correspondence Source Type: research