Face-down positioning or posturing after pars plana vitrectomy for macula-involving rhegmatogenous retinal detachments
CONCLUSIONS: Very low certainty evidence suggests that immediate face-down positioning after PPV and gas tamponade may result in a reduction in postoperative retinal displacement, outer retinal folds, and binocular diplopia, but may increase the chance of postoperative raised intraocular pressure compared with support-the-break positioning at six months. We identified two ongoing trials that compare face-down positioning with face-up positioning following PPV and gas tamponade in participants with primary macula-involving RRDs, whose results may provide relevant evidence for our stated objectives. Future trials should be r...
Source: Cochrane Database of Systematic Reviews - March 15, 2024 Category: General Medicine Authors: Timothy Hm Fung Tsz Wing Yim Noemi Lois David M Wright Su-Hsun Liu Tom Williamson Source Type: research

Antibiotic prophylaxis for leptospirosis
CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | PMC:PMC10938880 | DOI:10.1002/14651858.CD014959.pub2 (So...
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research

Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | PMC:PMC10938876 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research

Antibiotic prophylaxis for leptospirosis
CONCLUSIONS: We do not know if antibiotics versus placebo or another antibiotic has little or have no effect on all-cause mortality or leptospirosis infection because the certainty of evidence is low or very low. We do not know if antibiotics versus placebo may increase the overall risk of non-serious adverse events because of very low-certainty evidence. We lack definitive rigorous data from randomised trials to support the use of antibiotics for the prophylaxis of leptospirosis infection. We lack trials reporting data on clinically relevant outcomes.PMID:38483067 | DOI:10.1002/14651858.CD014959.pub2 (Source: Cochrane Dat...
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Tanaraj Perinpanathan Patrick Mukadi Chris Smith Tansy Edwards Su Myat Han Hsu Thinzar Maung David M Brett-Major Nathaniel Lee Source Type: research

Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse
CONCLUSIONS: While transvaginal permanent mesh is associated with lower rates of awareness of prolapse, repeat surgery for prolapse, and prolapse on examination than native tissue repair, it is also associated with higher rates of total repeat surgery (for prolapse, stress urinary incontinence, or mesh exposure), bladder injury, and de novo stress urinary incontinence. While the direction of effects and effect sizes are relatively unchanged from the 2016 version of this review, the certainty and precision of the findings have all improved with a larger sample size. In addition, the clinical relevance of these data has impr...
Source: Cochrane Database of Systematic Reviews - March 13, 2024 Category: General Medicine Authors: Ellen Yeung Kaven Baessler Corina Christmann-Schmid Nir Haya Zhuoran Chen Sheila A Wallace Alex Mowat Christopher Maher Source Type: research

Transvaginal mesh or grafts or native tissue repair for vaginal prolapse
CONCLUSIONS: While transvaginal permanent mesh is associated with lower rates of awareness of prolapse, repeat surgery for prolapse, and prolapse on examination than native tissue repair, it is also associated with higher rates of total repeat surgery (for prolapse, stress urinary incontinence, or mesh exposure), bladder injury, and de novo stress urinary incontinence. While the direction of effects and effect sizes are relatively unchanged from the 2016 version of this review, the certainty and precision of the findings have all improved with a larger sample size. In addition, the clinical relevance of these data has impr...
Source: Cochrane Database of Systematic Reviews - March 13, 2024 Category: General Medicine Authors: Ellen Yeung Kaven Baessler Corina Christmann-Schmid Nir Haya Zhuoran Chen Sheila A Wallace Alex Mowat Christopher Maher Source Type: research

Therapeutic vaccines for advanced non-small cell lung cancer
CONCLUSIONS: Adding a vaccine resulted in no differences in overall survival, except for racotumomab, which showed some improvement compared to placebo, but the difference in median survival time was very small (1.4 months) and the study only included 176 participants. Regarding progression-free survival, we observed no differences between the compared treatments, except for TG4010, which may increase progression-free survival slightly. There were no differences between the compared treatments in serious treatment-related adverse events, except for SRL172 (killed Mycobacterium vaccae) added to chemotherapy, which was assoc...
Source: Cochrane Database of Systematic Reviews - March 12, 2024 Category: General Medicine Authors: Marcela Cort és-Jofré Mikel Rueda-Etxebarria Emeline Orillard Elena Jimenez Tejero Jos é-Ramón Rueda Source Type: research

Cognitive behavioural therapy added to standard care for first-episode and recent-onset psychosis
CONCLUSIONS: This review synthesised the latest evidence on CBT added to standard care for people with a first-episode or recent-onset psychosis. The evidence identified by this review suggests that people with a first-episode or recent-onset psychosis may benefit from CBT additionally to standard care for multiple outcomes (overall, positive, negative and depressive symptoms of schizophrenia, global state and functioning). Future studies should better define this population, for which often heterogeneous definitions are used.PMID:38470162 | DOI:10.1002/14651858.CD015331.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 12, 2024 Category: General Medicine Authors: Susanna Franziska Mayer Ciaran Corcoran Liam Kennedy Stefan Leucht Irene Bighelli Source Type: research

Purse-string skin closure versus linear skin closure in people undergoing stoma reversal
CONCLUSIONS: PSSC compared with LSC likely reduces the risk of SSI in people undergoing reversal of stoma. People who have PSSC may be more satisfied with the result compared with people who have LSC. There may be little or no difference between the skin closure techniques in terms of incisional hernia and operative time, though the evidence for these two outcomes is very uncertain.PMID:38470607 | DOI:10.1002/14651858.CD014763.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 12, 2024 Category: General Medicine Authors: Shahab Hajibandeh Shahin Hajibandeh Andrew Maw Source Type: research

Compression for preventing recurrence of venous ulcers
CONCLUSIONS: Compression with EU class 3 compression stockings may reduce reulceration compared with no compression over six months. Use of EU class 1 compression stockings compared with EU class 2 compression stockings may result in little or no difference in reulceration and noncompliance over 12 months. UK class 3 compression hosiery may reduce reulceration compared with UK class 2 compression hosiery; however, higher compression may lead to lower compliance. There may be little to no difference between Scholl and Medi UK class 2 compression stockings in terms of reulceration and noncompliance. There was no information ...
Source: Cochrane Database of Systematic Reviews - March 7, 2024 Category: General Medicine Authors: Melissa Andreia de Moraes Silva Andrea Nelson Sally Em Bell-Syer Seleno G de Jesus-Silva Fausto Miranda Source Type: research

Exercise-based cardiac rehabilitation for adults with heart failure
CONCLUSIONS: This updated Cochrane review provides additional randomised evidence (16 trials) to support the conclusions of the previous 2018 version of the review. Compared to no exercise control, whilst there was no evidence of a difference in all-cause mortality in people with heart failure, ExCR participation likely reduces the risk of all-cause hospital admissions and heart failure-related hospital admissions, and may result in important improvements in HRQoL. Importantly, this updated review provides additional evidence supporting the use of alternative modes of ExCR delivery, including home-based and digitally-suppo...
Source: Cochrane Database of Systematic Reviews - March 7, 2024 Category: General Medicine Authors: Cal Molloy Linda Long Ify R Mordi Charlene Bridges Viral A Sagar Edward J Davies Andrew Js Coats Hasnain Dalal Karen Rees Sally J Singh Rod S Taylor Source Type: research

Compression for preventing recurrence of venous ulcers
CONCLUSIONS: Compression with EU class 3 compression stockings may reduce reulceration compared with no compression over six months. Use of EU class 1 compression stockings compared with EU class 2 compression stockings may result in little or no difference in reulceration and noncompliance over 12 months. UK class 3 compression hosiery may reduce reulceration compared with UK class 2 compression hosiery; however, higher compression may lead to lower compliance. There may be little to no difference between Scholl and Medi UK class 2 compression stockings in terms of reulceration and noncompliance. There was no information ...
Source: Cochrane Database of Systematic Reviews - March 7, 2024 Category: General Medicine Authors: Melissa Andreia de Moraes Silva Andrea Nelson Sally Em Bell-Syer Seleno G de Jesus-Silva Fausto Miranda Source Type: research

Exercise-based cardiac rehabilitation for adults with heart failure
CONCLUSIONS: This updated Cochrane review provides additional randomised evidence (16 trials) to support the conclusions of the previous 2018 version of the review. Compared to no exercise control, whilst there was no evidence of a difference in all-cause mortality in people with heart failure, ExCR participation likely reduces the risk of all-cause hospital admissions and heart failure-related hospital admissions, and may result in important improvements in HRQoL. Importantly, this updated review provides additional evidence supporting the use of alternative modes of ExCR delivery, including home-based and digitally-suppo...
Source: Cochrane Database of Systematic Reviews - March 7, 2024 Category: General Medicine Authors: Cal Molloy Linda Long Ify R Mordi Charlene Bridges Viral A Sagar Edward J Davies Andrew Js Coats Hasnain Dalal Karen Rees Sally J Singh Rod S Taylor Source Type: research

Compression for preventing recurrence of venous ulcers
CONCLUSIONS: Compression with EU class 3 compression stockings may reduce reulceration compared with no compression over six months. Use of EU class 1 compression stockings compared with EU class 2 compression stockings may result in little or no difference in reulceration and noncompliance over 12 months. UK class 3 compression hosiery may reduce reulceration compared with UK class 2 compression hosiery; however, higher compression may lead to lower compliance. There may be little to no difference between Scholl and Medi UK class 2 compression stockings in terms of reulceration and noncompliance. There was no information ...
Source: Cochrane Database of Systematic Reviews - March 7, 2024 Category: General Medicine Authors: Melissa Andreia de Moraes Silva Andrea Nelson Sally Em Bell-Syer Seleno G de Jesus-Silva Fausto Miranda Source Type: research