The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population.
Conclusion: These findings cannot support contribution of rs1042522 polymorphism to breast cancer risk in an Iranian population. Future larger studies may help confirm this finding with a greater power. PMID: 31721533 [PubMed] (Source: Cancer Control)
Source: Cancer Control - November 15, 2019 Category: Cancer & Oncology Authors: Afzaljavan F, Chaeichi Tehrani N, Rivandi M, Zarif Ghasemian S, Vahednia E, Khayami R, Abavisani M, Pasdar A Tags: Cell J Source Type: research

[Tonsil surgery in the federal states of Germany: similarities and differences. German version].
CONCLUSION: The change of trends in tonsil surgery started long before relevant national guidelines were published. The national trend was associated with considerably less surgical activity overall, a significant decrease in ATE/TE, and a significant increase in TT. Regional differences to the national trend were identified and found to be significant in at least in 7 of 16 federal states. PMID: 31720695 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 15, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Factors Predicting Operative Difficulty of Laparoscopic Total Mesorectal Excision
CONCLUSION: Patient, tumor, and bony pelvic anatomical characteristics are not seen to influence laparoscopic total mesorectal excision operative difficulty. Mesorectal area is identified as a risk factor for intraoperative and postoperative morbidity. See Video Abstract at FACTORES QUE PREDICEN LA DIFICULTAD OPERATIVA DE LA ESCISIÓN MESORRECTAL TOTAL LAPAROSCÓPICA ANTECEDENTES: La escisión mesorrectal total laparoscópica es un procedimiento desafiante. Para obtener resultados óptimos, se requiere cirugía de alta calidad. Se cree que, factores co...
Source: Diseases of the Colon and Rectum - November 15, 2019 Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research

Long-term Outcomes of Balloon Dilation for Persistent Eustachian Tube Dysfunction
Objective: To gather long-term follow-up data on the efficacy of balloon dilation for treating patients with persistent Eustachian tube dysfunction (ETD). Study Design: Extended follow-up study of the treatment arm of a prospective, multicenter, randomized controlled trial. Setting: Tertiary care academic center and private practice. Patients: Patients diagnosed with medically refractory persistent ETD. Interventions: Balloon dilation of the Eustachian tube. Main Outcome Measures: The endpoints were the mean change from baseline in the 7-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7) score, revisi...
Source: Otology and Neurotology - November 15, 2019 Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research

Long-term Outcomes in Down Syndrome Children After Cochlear Implantation: Particular Issues and Considerations
Objective: The aim of the study was to analyze the long-term outcomes after cochlear implantation in deaf children with Down syndrome (DS) regarding age at the first implantation and refer the results to preoperative radiological findings as well as postoperative auditory and speech performance. Additionally, the influence of the age at implantation and duration of CI use on postoperative hearing and language skills were closely analyzed in children with DS. Study Design: Retrospective analysis. Setting: Referral center (Cochlear Implant Center). Materials and Methods: Nine children with Down syndrome were compa...
Source: Otology and Neurotology - November 15, 2019 Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research

Modelling driver propensity for traffic accidents: a comparison of multiple regression analysis and fuzzy approach.
Authors: Čubranić-Dobrodolac M, Švadlenka L, Čičević S, Dobrodolac M Abstract This research proposes an assessment and decision support model to use when a driver should be examined about their propensity for traffic accidents, based on an estimation of the driver's psychological traits. The proposed model was tested on a sample of 305 drivers. Each participant completed four psychological tests: the Barratt Impulsiveness Scale (BIS-11), the Aggressive Driving Behaviour Questionnaire (ADBQ), the Manchester Driver Attitude Questionnaire (DAQ) and the Questionnaire for Self-assessment of Driving Ability. ...
Source: International Journal of Injury Control and Safety Promotion - November 15, 2019 Category: Accident Prevention Tags: Int J Inj Contr Saf Promot Source Type: research

[Turning point in skin cancer mortality : An analysis of the trend in Germany from 1998 to 2017].
The objective of this study is to investigate current trends of skin cancer mortality in Germany. Data of the death statistics from 1998 to 2017 were analyzed using joinpoint regression models. Age standardized skin cancer mortality declined since 2013 (annual percentage change -2.1% [95% CI: -4.0 to -0.2%]), while in previous years an increase of +3.4% (95% CI: 1.3 to 5.4%) was observed. The development is mainly driven by a decreasing melanoma mortality. Possible causes of the trend change are especially the nationwide skin cancer screening which was introduced in 2008 and the growing availability of new system...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - November 15, 2019 Category: Dermatology Tags: Hautarzt Source Type: research

Optimal prediction of process parameters by GWO-KNN in stirring-squeeze casting of AA2219 reinforced metal matrix composites
Publication date: Available online 13 November 2019Source: Materials Today: ProceedingsAuthor(s): T. Adithiyaa, D. Chandramohan, T. SathishAbstractRapid globalization and demand for the advanced material, hybrid materials are possessing an up marketed strategy in the field of material research. Due to the demand for lightweight and strong nature of materials, aluminium is considered as largely utilized material for manufacturing components in industrial and other manufacturing sectors. However, aluminium materials are being researched through the decades for improvising the mechanical properties. Therefore, hybrid matrix c...
Source: Materials Today: Proceedings - November 15, 2019 Category: Materials Science Source Type: research

A Non-invasive Method for Determining Biomechanical Properties of the Internal Carotid Artery
Publication date: Available online 14 November 2019Source: IRBMAuthor(s): A. Ayadi, W. Sahtout, O. BalédentAbstractObjectivesMechanical properties of the carotid artery play an important role in the progression of arterial disease such as atherosclerosis. An early change in the mechanical properties of the arteries can be introduced as a novel risk factor for cardiovascular events. The aim of this study is to estimate, in vivo, the elastic biomechanical properties of the internal carotid wall (ICA), from the noninvasive determination of the local arterial wave speed (c).Material and methodsTo achieve this objective,...
Source: IRBM - November 15, 2019 Category: Biomedical Engineering Source Type: research

Measurements of volumetric bone mineral density in the mandible do not predict spinal osteoporosis.
The objective of this study was to determine whether the trabecular volumetric Bone Mineral Density (vBMD) of the middle, body and angle of the mandible correlates with vBMD of the cervical and lumbar vertebrae in a Chinese population. METHODS AND MATERIALS: Six hundred and sixty one subjects (270 males, 391 females), ranging from 20 to 59 years of age, were recruited for vBMD measurements by quantitative computed tomography (QCT). Basic information (age, height and weight), vBMD of the mandible (middle, body and angle sites), and vBMD of the cervical and lumbar vertebrae were recorded. Spearman's rank correlation test...
Source: Dentomaxillofacial Radiology - November 15, 2019 Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research

Evaluation of functional disability after Chikungunya infection
CONCLUSIONS Patients in the chronic phase of CHIK present functional disability, thus alerting healthcare professionals to the importance of implementing actions aimed at an adequate treatment in all phases of the disease, mainly related to pain treatment and motor rehabilitation. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - November 15, 2019 Category: Tropical Medicine Source Type: research

Factors that negatively influence the Glasgow Outcome Scale in patients with chronic subdural hematomas. An analytical and retrospective study in a tertiary center
ConclusionsChronic neurosurgical pathologies are chronic subdural hematomas, in a high percentage they are subsidiary of surgical treatment. There are several factors that negatively influence the prognosis in patients and that should be considered for both the surgical decision and patient / family agreement and for the medium / long-term follow-up of them. (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - November 15, 2019 Category: Neurosurgery Source Type: research

Prevalence and Alternative Treatment of Head-Lice Infestation in Rural Thailand: A Community-Based Study.
In conclusion, behavior-change communication should be implemented to reduce the observed high prevalence of headlice infestation. Ivermectin may be an alternative choice for head-lice treatment, especially in remote areas. PMID: 31715690 [PubMed - in process] (Source: Korean Journal of Parasitology)
Source: Korean Journal of Parasitology - November 15, 2019 Category: Parasitology Tags: Korean J Parasitol Source Type: research

Technology Assisted Behavior Intervention to Extend Sleep Among Adults With Short Sleep Duration and Prehypertension/Stage 1 Hypertension: A Randomized Pilot Feasibility Study
Study Objectives:Short sleep duration contributes to hypertension, yet few behavioral sleep extension interventions have been developed. The goal of our study was to evaluate the feasibility and preliminary efficacy of a technology assisted sleep extension intervention among individuals with prehypertension/stage 1 hypertension on sleep, blood pressure and patient reported outcomes.Methods:Adults aged 30–65 with 24h ambulatory blood pressure (ABP)> 120/80 mmHg and average weekday sleep duration
Source: Journal of Clinical Sleep Medicine : JCSM - November 15, 2019 Category: Sleep Medicine Source Type: research

Validation of Fitbit Charge 2 and Fitbit Alta HR Against Polysomnography for Assessing Sleep in Adults With Obstructive Sleep Apnea
Conclusions:Fitbit wearable devices showed an acceptable sensitivity but poor specificity. Consumer sleep trackers still have insufficient accuracy for clinical settings, especially in clinical populations. Solving technical issues and optimizing clinically-oriented features could make them apt for their use in clinical practice in a nondistant future.Citation:Moreno-Pino F, Porras-Segovia A, López-Esteban P, Artés A, Baca-García E. Validation of Fitbit Charge 2 and Fitbit Alta HR against polysomnography for assessing sleep in adults with obstructive sleep apnea.J Clin Sleep Med. 2019;15(11):1645&ndash...
Source: Journal of Clinical Sleep Medicine : JCSM - November 15, 2019 Category: Sleep Medicine Source Type: research

Intention-behaviour gap and perceived behavioural control-behaviour gap in theory of planned behaviour: moderating roles of communication, satisfaction and trust in organic food consumption
This study examines the moderating effects of perceived communication, satisfaction and trust on the intention-behaviour gap and the perceived behavioural control (PBC)-behaviour gap in the theory of planned behaviour (TPB) model, using a quantitative research method. A nationwide panel-only online survey was conducted, resulting in 1011 usable responses from organic food consumers in Australia. Data were analysed statistically using SPSS v.25 and SmartPLS 3 software, and the hypotheses were tested using the partial least squares-based structural equation modelling (PLS-SEM) technique. The findings confirm that perceived c...
Source: Food Quality and Preference - November 15, 2019 Category: Food Science Source Type: research

Is it possible to shorten serum bactericidal testing?
Publication date: Available online 13 November 2019Source: Journal of Microbiological MethodsAuthor(s): Paterova Pavla, Radocha Jakub, Buchta Vladimir, Zavrelova Alzbeta, Malakova Jana, Zak Pavel, Zemlickova HelenaAbstractSerum bactericidal test represents an alternative possibility for optimization of antibiotic treatment. The paper aimed to confirm non-inferiority of bactericidal testing using the broth dilution method according to the CLSI method (M21A) in comparison with turbidimetric and colorimetric modifications. We tested human blood sera (n = 76) of ten hematological patients, their blood was withdrawn prior t...
Source: Journal of Microbiological Methods - November 15, 2019 Category: Microbiology Source Type: research

Bayesian inference for damage identification based on analytical probabilistic model of scattering coefficient estimators and ultrafast wave scattering simulation scheme
This study presents a generic framework for probabilistic damage characterization within complex structures, based on physics-rich information on ultrasound wave interaction with existent damage. To this end, the probabilistic model of wave scattering properties estimated from measured GWs is inferred based on absolute complex-valued ratio statistics. Based on the probabilistic model, the likelihood function connecting the scattering properties predicted by a computational model containing the damage parametric description and the scattering estimates is formulated within a Bayesian system identification framework to accou...
Source: Journal of Sound and Vibration - November 15, 2019 Category: Physics Source Type: research

Investigating Structural Requirements of Some Pyrimidine-linked Benzimidazole Derivatives as Anticancer Agents Against MCF-7 Cancerous Cell Line Through the use of 2D and 3D QSARs
Conclusion: These 2D and 3D models were found to give dependable indications which helped to optimize the pyrimidine-benzimidazole derivatives of the data set. The data yielded by 2D- QSAR and 3D-QSAR models will aid in giving better perceptions about structural requirements for developing newer anticancer agents. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research

Specific Enzymatic Activity of Ceruloplasmin as a Potential Indicator of Copper Status
Conclusion: The study revealed that clinical group was significantly different in specific enzymatic activity of Cp as compared to control group. Besides this, the specific enzymatic activity of Cp was moderately but significantly correlated with serum Cu level in control group but did not reveal conclusive evidence in clinical population. (Source: Current Chemical Biology)
Source: Current Chemical Biology - November 15, 2019 Category: Biochemistry Source Type: research

SEQdata-BEACON: a comprehensive database of sequencing performance and statistical tools for performance evaluation and yield simulation in BGISEQ-500
The sequencing platform BGISEQ-500 is based on DNBSEQ technology and provides high throughput with low costs. This sequencer has been widely used in various areas of scientific and clinical research. A better ... (Source: BioData Mining)
Source: BioData Mining - November 15, 2019 Category: Bioinformatics Authors: Yanqiu Zhou, Chen Liu, Rongfang Zhou, Anzhi Lu, Biao Huang, Liling Liu, Ling Chen, Bei Luo, Jin Huang and Zhijian Tian Tags: Research Source Type: research

Following the legacy of professors Barbara Starfield and Leiyu Shi in Brazil as health policy: the National Health Survey (PNS), led by the Brazilian National Institute of Geography and Statistics (IBGE) and the Primary Care Assessment Tool (PCAT)
We present to the scientific community the pioneering of Brazilian National Institute of Geography and Statistics (IBGE, the Brazilian Census Bureau) in partnership with the Ministry of Health, the largest fie... (Source: International Journal for Equity in Health)
Source: International Journal for Equity in Health - November 15, 2019 Category: International Medicine & Public Health Authors: Erno Harzheim, Luiz Felipe Pinto, Otavio Pereira D ’Avila and Lisiane Hauser Tags: Letter to the Editor Source Type: research

Validity of Maternal Report of Birthweight in a Cohort Study and Its Implication on Low Birthweight Rate Using Simulations.
Abstract OBJECTIVE: Maternal recall of birthweight is a convenient and cost-effective way to obtain birthweight measurements when official records are unavailable. It is important to assess the validity of maternal recall of birthweight before using these measurements to draw conclusions about a population. METHODS: This is secondary analysis of data from a previous cohort study. We analyzed actual and reported birthweights of 200 mother-and-child pairs from Southern India. We validated maternal report of birthweight by generating correlation coefficients, summary statistics, and Bland-Altman plots. We ran si...
Source: Indian Pediatrics - November 15, 2019 Category: Pediatrics Authors: Swaminathan A, Thomas T, Corsi DJ, Dwarkanath P, Subramanian SV, Kurpad AV Tags: Indian Pediatr Source Type: research

Effect of Different Doses of Inhaled Corticosteroids on the Isolation of Nasopharyngeal Flora in Children with Asthma.
CONCLUSIONS: Inhaled corticosteroids are safe in the treatment of asthma and there is no association between different doses of Inhaled corticosteroids and isolation of the pathogenic organism. PMID: 31729320 [PubMed - in process] (Source: Indian Pediatrics)
Source: Indian Pediatrics - November 15, 2019 Category: Pediatrics Authors: Nirmal G, Awasthi S, Gupta S, Aggarwal J Tags: Indian Pediatr Source Type: research

Validation by CT scan of quadriceps muscle thickness measurement by ultrasound in acute kidney injury.
CONCLUSION: In critically ill patients with AKI, quadriceps muscle thickness assessment based on US is unbiased, although it occurs with a minor loss of precision compared to CT. PMID: 31729699 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - November 15, 2019 Category: Urology & Nephrology Authors: Sabatino A, Regolisti G, di Mario F, Ciuni A, Palumbo A, Peyronel F, Maggiore U, Fiaccadori E Tags: J Nephrol Source Type: research

Role of human papillomavirus in laryngeal squamous cell carcinoma: A meta ‐analysis of cohort study
ConclusionThis study evaluated the survival impact of HPV infection in LSCC patients. The OS of the HPV ‐positive group was better than that of the HPV‐negative group in terms of short‐term survival. Compared with the HPV‐negative group, the HPV‐positive group had a better trend of DFS, suggesting that a larger sample size and further exploration of the pathology and local control of HPV‐p ositive tumors are needed. (Source: Cancer Medicine)
Source: Cancer Medicine - November 15, 2019 Category: Cancer & Oncology Authors: Huanhuan Wang, Jinlong Wei, Bin Wang, Lingbin Meng, Ying Xin, Lihua Dong, Xin Jiang Tags: ORIGINAL ARTICLE Source Type: research

Extranodal marginal zone B ‐cell lymphoma of mucosa‐associated lymphoid tissue in the oromaxillofacial head and neck region: A retrospective analysis of 105 patients
ConclusionsThis study suggests that the outcome after initial treatment of MALT lymphomas in the oromaxillofacial head and neck region is satisfactory and that this disease progresses slowly. The CR rate and PFS of localized lymphoma patients are better than those of disseminated lymphoma patients. Systemic treatment (chemotherapy or rituximab) may improve PFS in disseminated disease patients. MALT ‐IPI and Ann Arbor staging are independent prognostic factors. (Source: Cancer Medicine)
Source: Cancer Medicine - November 15, 2019 Category: Cancer & Oncology Authors: Tian Zhang, Yunteng Wu, Houyu Ju, Jian Meng, Wei Guo, Guoxin Ren Tags: ORIGINAL RESEARCH Source Type: research

Temperature dependence of NMR chemical shifts: tracking and statistical analysis
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - November 15, 2019 Category: Biochemistry Authors: Kyle Trainor, Jeffrey A. Palumbo, Duncan W.S. MacKenzie, Elizabeth M. Meiering Tags: Tools for Protein Science Source Type: research

Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning.
Abstract Carbon monoxide poisoning (COP) may increase the risk of myocardial infarction. We conducted a study to investigate the effects of hyperbaric oxygen therapy (HBOT) on the risk. We used the Nationwide Poisoning Database in Taiwan to identify COP patients diagnosed between 1999 and 2012. We compared the risk for myocardial infarction between patients with and without HBOT by following up through 2013 and identified the independent predictors of myocardial infarction. The risk of myocardial infarction in the 7278 patients with HBOT was lower than in the 18,459 patients without HBOT, but this difference did n...
Source: Cardiovascular Toxicology - November 15, 2019 Category: Cardiology Authors: Huang CC, Ho CH, Chen YC, Hsu CC, Lin HJ, Wang JJ, Su SB, Guo HR Tags: Cardiovasc Toxicol Source Type: research

Penalized regression models to select biomarkers of environmental enteric dysfunction associated with linear growth acquisition in a Peruvian birth cohort
by Josh M. Colston, Pablo Pe ñataro Yori, Lawrence H. Moulton, Maribel Paredes Olortegui, Peter S. Kosek, Dixner Rengifo Trigoso, Mery Siguas Salas, Francesca Schiaffino, Ruthly François, Fahmina Fardus-Reid, Jonathan R. Swann, Margaret N. Kosek Environmental enteric dysfunction (EED) is associated with chronic undernutrition. Efforts to identify minimally invasive biomarkers of EED reveal an expanding number of candidate analytes. An analytic strategy is reported to select among candidate biomarkers and systematically express the strengt h of each marker’s association with linear growth in infancy and...
Source: PLoS Neglected Tropical Diseases - November 15, 2019 Category: Tropical Medicine Authors: Josh M. Colston Source Type: research

Risk stratification for nonagenarians undergoing transcatheter aortic valve replacement
ConclusionIntermediate ‐risk nonagenarians undergoing TAVR have similar postoperative outcomes compared to intermediate‐risk octogenarians. However, high‐risk nonagenarian patients undergoing TAVR experience significantly poorer outcomes compared to their octogenarian counterparts. Judicious patient selection for TA VR in this subgroup of patients is therefore warranted. (Source: Journal of Cardiac Surgery)
Source: Journal of Cardiac Surgery - November 15, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Pey ‐Jen Yu, Michael Catalano, Robert Palazzo, Hugh Cassiere, Nina Kohn, Bruce Rutkin, Greg Maurer, Jacinda A. Berg, Alan Hartman Tags: ORIGINAL ARTICLE Source Type: research

Analysis of 55 Kidd Ancestry SNP of Qatari population using Structure & ForenSeq Universal Software
SNPs are good predictors of ethnicity and serval panels have been published [1]. The ForenSeq Signature kit (Illumina) offers coverage of 230 different markers including 55 ancestry SNPs (AISNPS). The ForenSeq Universal Analysis Software (UAS) brings the capability to analyse the sequencing data, represent results and accomplish statistical estimates of biogeographic ancestry. The ancestry prediction results in UAS are based on Principal Component Analysis (PCA) collected on several reference populations comprised in the 1000 Genomes project. (Source: Forensic Science International: Genetics Supplement Series)
Source: Forensic Science International: Genetics Supplement Series - November 15, 2019 Category: Forensic Medicine Authors: E. Almohammed, S. Hadi Source Type: research

Multiple event times in the presence of informative censoring: modeling and analysis by copulas
AbstractMotivated by a breast cancer research program, this paper is concerned with the joint survivor function of multiple event times when their observations are subject to informative censoring caused by a terminating event. We formulate the correlation of the multiple event times together with the time to the terminating event by an Archimedean copula to account for the informative censoring. Adapting the widely used two-stage procedure under a copula model, we propose an easy-to-implement pseudo-likelihood based procedure for estimating the model parameters. The approach yields a new estimator for the marginal distrib...
Source: Lifetime Data Analysis - November 15, 2019 Category: Statistics Source Type: research

Frequent inappropriate use of unweighted summary statistics in systematic reviews of pathogen genotypes or genogroups
Our study aims to systematically assess and report the methodological quality used in epidemiological systematic reviews (SRs) and meta-analysis (MA) of pathogen genotypes/genogroups. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - November 15, 2019 Category: Epidemiology Authors: Linh Tran, Mai Nhu Y, Thai Le Ba Nghia, Abdulrahman Hendam, Nguyen Lam Vuong, Ebrahim Alzalal, Ahmed M. Sayed, Mustafa Mushtaq Hussain, Akash Sharma, Thuan Tieu, Peterson Gitonga Mathenge, Kenji Hirayama, Neal Alexander, Nguyen Tien Huy Tags: Review Source Type: research

Genome-Wide Study Updates in the International Genetics and Translational Research in Transplantation Network (iGeneTRAiN)
The prevalence of end-stage renal disease (ESRD) and the number of kidney transplants performed continues to rise every year, straining the procurement of deceased and living kidney allografts and health systems. Genome-wide genotyping and sequencing of diseased populations have uncovered genetic contributors in substantial proportions of ESRD patients. A number of these discoveries are beginning to be utilized in risk stratification and clinical management of patients. Specifically, genetics can provide insight into the primary cause of chronic kidney disease (CKD), the risk of progression to ESRD, and post-transplant out...
Source: Frontiers in Genetics - November 15, 2019 Category: Genetics & Stem Cells Source Type: research

AIDE: annotation-assisted isoform discovery with high precision [METHOD]
Genome-wide accurate identification and quantification of full-length mRNA isoforms is crucial for investigating transcriptional and posttranscriptional regulatory mechanisms of biological phenomena. Despite continuing efforts in developing effective computational tools to identify or assemble full-length mRNA isoforms from second-generation RNA-seq data, it remains a challenge to accurately identify mRNA isoforms from short sequence reads owing to the substantial information loss in RNA-seq experiments. Here, we introduce a novel statistical method, annotation-assisted isoform discovery (AIDE), the first approach that dir...
Source: Genome Research - November 15, 2019 Category: Genetics & Stem Cells Authors: Li, W. V., Li, S., Tong, X., Deng, L., Shi, H., Li, J. J. Tags: METHOD Source Type: research

Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies
by Andrew Schlafly, Ruth M. Pfeiffer, Eduardo Nagore, Susana Puig, Donato Calista, Paola Ghiorzo, Chiara Menin, Maria Concetta Fargnoli, Ketty Peris, Lei Song, Tongwu Zhang, Jianxin Shi, Maria Teresa Landi, Joshua Neil Sampson Despite genetics being accepted as the primary cause of familial aggregation for most diseases, it is still unclear whether afflicted families are likely to share a single highly penetrant rare variant, many minimally penetrant common variants, or a combination of the two types of variants. We the refore use recent estimates of SNP heritability and the liability threshold model to estimate the propo...
Source: PLoS Genetics - November 15, 2019 Category: Genetics & Stem Cells Authors: Andrew Schlafly Source Type: research

Short-term  outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy used as treatment of colo-rectal carcinomatosis: a multicentric study
AbstractThe aim of this study is to assess the morbidity and mortality related to cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colo-rectal carcinomatosis. A retrospective multi-institutional study from seven Italian Centers was performed. One hundred and seventy-two patients, submitted to cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) to treat carcinomatosis of colorectal origin, were recorded. Postoperative morbidity was evaluated in accordance with the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (...
Source: Updates in Surgery - November 15, 2019 Category: Surgery Source Type: research

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: protocol and statistical considerations
Kidney disease caused by type 1 diabetes can progress to end stage renal disease and can increase mortality risk. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) plays a major role in producing oxidative stress in the kidney in diabetes, and its activity is attenuated by GKT137831, an oral Nox inhibitor with predominant inhibitory action on Nox-1 and Nox  − 4. Previous studies have demonstrated renoprotective effects with GKT137831 in various experimental models of type 1 diabetes-related kidney disease. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - November 15, 2019 Category: Radiology Authors: Anne T. Reutens, Karin Jandeleit-Dahm, Merlin Thomas, Leon A. Bach, Peter G. Colman, Timothy M.E. Davis, Michael D'Emden, Elif I. Ekinci, Greg Fulcher, Peter Shane Hamblin, Mark A. Kotowicz, Richard J. MacIsaac, Claire Morbey, David Simmons, Georgia Solda Source Type: research

Potential impact of diabetes prevention on mortality and future burden of dementia and disability: a modelling study
Conclusions/interpretationReducing the burden of diabetes could result in substantial reductions in the incidence of dementia and disability over the medium to long term. (Source: Diabetologia)
Source: Diabetologia - November 15, 2019 Category: Endocrinology Source Type: research

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study
This study assessed the impact of older age on docetaxel PK, also considering the effect of indication on docetaxel PK.MethodsProspectively collected docetaxel PK data from patients aged ≥70 was pooled with PK data from an earlier published multicenter study. A 3-compartment population PK model, including multiple covariates, was used to describe docetaxel plasma concentration-time data. We added the effect of prostate cancer (mCRPC and metastatic hormone-sensitive prostate cancer (mHSPC)) on clearance to this model. Hereafter, we evaluated the additional impact of older age on docetaxel clearance, using a significance ...
Source: Pharmaceutical Research - November 15, 2019 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 11, Pages 1798: Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
In conclusion, TMB may be an effective biomarker to predict survival in patients undergoing ICI treatment. The role of TMB in identifying patient groups who may benefit from ICIs should be determined in future randomized controlled trials. (Source: Cancers)
Source: Cancers - November 15, 2019 Category: Cancer & Oncology Authors: Jong Yeob Kim Andreas Kronbichler Michael Eisenhut Sung Hwi Hong Hans J. van der Vliet Jeonghyun Kang Jae Il Shin Gabriele Gamerith Tags: Article Source Type: research

Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors.
This study examined the incidence of teicoplanin ADRs and risk factors for cross-reactivity between vancomycin and teicoplanin. Methods: We analyzed the incidence of teicoplanin ADRs in a retrospective study of 304 newly teicoplanin-exposed, immunocompetent, hospitalized patients at a single Korean Medical Center between January 1, 2006 and December 31, 2015. Results: Among 304 patients, 238 (78.3%) experienced vancomycin-associated ADRs prior to their teicoplanin exposure and 58 (19.1%) experienced teicoplanin- associated ADRs, which were mostly hypersensitivity reactions without acute kidney injury. The inciden...
Source: The Korean Journal of Internal Medicine - November 15, 2019 Category: Internal Medicine Authors: Kim BK, Kim JH, Sohn KH, Kim JY, Chang YS, Kim SH Tags: Korean J Intern Med Source Type: research

Automatic delineation algorithm of reference region for amyloid imaging based on kinetics
ConclusionsAutoRef presents the same performance as the manual definition of the reference region. Further, since AutoRef is more algorithmic than the ordinary manual definition of the reference region, there are few operator-oriented uncertainties in AutoRef. We thus conclude that AutoRef can be applied as an automatic delineating algorithm for the reference region in amyloid imaging. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - November 15, 2019 Category: Nuclear Medicine Source Type: research

Group sequential tests for treatment effect on survival and cumulative incidence at a fixed time point
AbstractMedical research frequently involves comparing an event time of interest between treatment groups. Rather than comparing the entire survival or cumulative incidence curves, it is sometimes preferable to evaluate these probabilities at a fixed point in time. Performing a covariate adjusted analysis can improve efficiency, even in randomized clinical trials, but no currently available group sequential test for fixed point analysis provides this adjustment. This paper introduces covariate adjusted group sequential pointwise comparisons of survival and cumulative incidence probabilities. Their test statistics have an a...
Source: Lifetime Data Analysis - November 15, 2019 Category: Statistics Source Type: research

An alternative to confidence intervals constructed after a Hausman pretest in panel data
SummaryConsider panel data modelled by a linear random intercept model that includes a time ‐varying covariate. Suppose that our aim is to construct a confidence interval for the slope parameter. Commonly, a Hausman pretest is used to decide whether this confidence interval is constructed using therandom effects model or thefixed effects model. This post ‐model‐selection confidence interval has the attractive features that it (a) is relatively short when therandom effects model is correct and (b) reduces to the confidence interval based on thefixed effects model when the data and therandom effects model are highly di...
Source: Australian and New Zealand Journal of Statistics - November 15, 2019 Category: Statistics Authors: Paul Kabaila, Rheanna Mainzer Tags: Original Article Source Type: research

Molecules, Vol. 24, Pages 4131: The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of Stizolophus balsamita
This study aimed to evaluate the ability of natural parthenolide derivatives to inhibit serotonin release from platelets. Izospiciformin, stizolin and stizolicin were analysed along with the standardised alcohol extract of S. balsamita leaves, which also contained four other parthenolide derivatives. All the analysed substances were found to inhibit serotonin release from platelets as compared with the control sample, which had 100% of serotonin released. Izospiciformin had the most significant impact (97.98% serotonin release inhibition). The effect of the methanol extract of S. balsamita on the serotonin release inhibiti...
Source: Molecules - November 15, 2019 Category: Chemistry Authors: Joanna Nawrot Marta Napiera ła Kinga Kaczerowska-Pietrzak Ewa Florek Justyna Gornowicz-Porowska Ewa Pelant Gerard Nowak Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 4511: The Associations between the Duration of Folic Acid Supplementation, Gestational Diabetes Mellitus, and Adverse Birth Outcomes based on a Birth Cohort
This study aimed to examine the associations between the duration of folic acid (FA) supplementation, gestational diabetes mellitus (GDM), and adverse birth outcomes. A total of 950 mother-offspring pairs participated in the cohort study during 2015 in Changsha, China. The data were collected through home visits and perfected by maternal and child healthcare handbooks. Generalized linear models and stratified analyses were used for statistical analyses. The incidence of GDM in our cohort was 10.2%. FA supplementation for ≥3 months before pregnancy was associated with an increased risk of GDM (adjusted relative r...
Source: International Journal of Environmental Research and Public Health - November 15, 2019 Category: Environmental Health Authors: Gang Cheng Tingting Sha Xiao Gao Qiong He Xialing Wu Qianling Tian Fan Yang Cai Tang Xihong Wu Qunhui Xie Yan Yan Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 4519: An Empirical Study of Applying Statistical Disclosure Control Methods to Public Health Research
. P. So Patient data or information collected from public health and health care surveys are of great research value. Usually, the data contain sensitive personal information. Doctors, nurses, or researchers in the public health and health care sector do not analyze the available datasets or survey data on their own, and may outsource the tasks to third parties. Even though all identifiers such as names and ID card numbers are removed, there may still be some occasions in which an individual can be re-identified via the demographic or particular information provided in the datasets. Such data privacy issues can become ...
Source: International Journal of Environmental Research and Public Health - November 15, 2019 Category: Environmental Health Authors: Amanda M. Y. Chu Benson S. Y. Lam Agnes Tiwari Mike K. P. So Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 4524: Anthropometric, Cardiopulmonary and Metabolic Benefits of the High-Intensity Interval Training Versus Moderate, Low-Intensity or Control for Type 2 Diabetes: Systematic Review and Meta-Analysis
This study aims to evaluate the effectiveness of high-intensity interval training compared with no intervention and other types of training interventions for people with Type 2 Diabetes. A systematic review and meta-analysis of randomized controlled trials that used high-interval intensity training to improve anthropometric, cardiopulmonary and metabolic conditions were conducted. The search was performed during October–December 2017 using the databases PubMed, Web of Science and Physiotherapy Evidence Database (PEDro). The methodological quality of the studies was evaluated using the PEDro scale. A total of ...
Source: International Journal of Environmental Research and Public Health - November 15, 2019 Category: Environmental Health Authors: Lora-Pozo Lucena-Anton Salazar Gal án-Mercant Moral-Munoz Tags: Review Source Type: research