Unravelling variations: an examination of entry point selection in proximal femoral cephalomedullary nailing
ConclusionsSignificant variations exist in surgeons ’ selection of entry points for proximal femoral nailing, underscoring the task’s complexity. Experience does not prevent the choice of unfeasible entry points, emphasizing the inadequacy of a universal approach and pointing towards the necessity for a patient-specific strategy for improved outc omes.Trial registration number: DRKS00032465. (Source: Journal of Orthopaedics and Traumatology)
Source: Journal of Orthopaedics and Traumatology - April 23, 2024 Category: Orthopaedics Source Type: research
Postoperative complications after surgery for lumbar spinal stenosis, assessment using two different data sources
ConclusionPostoperative complications occurred in 22% of LSS patients. The frequency of different postoperative complications differed between the two data sources. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 23, 2024 Category: Neurosurgery Source Type: research
Correlation analysis of serum TLR4 protein levels and < i > TLR4 gene < /i > polymorphisms in gouty arthritis patients
by Lu Liu, Shuang He, Lin Jia, Hua Yao, Dan Zhou, Xiaobin Guo, Lei Miao
ObjectiveThe Toll-like receptor (TLR) 4-mediated nuclear factor kappa B (NF- κB) signaling pathway regulates the production of inflammatory factors and plays a key role in the pathogenesis of gouty arthritis. The aim of the present study was to investigate the link amongTLR4 gene polymorphisms at various loci, protein expression, and gouty arthritis susceptibility. MethodsBetween 2016 and 2021, a case-control study was used to collect a total of 1207 study subjects, including 317 male patients with gouty arthritis (gout group) and 890 healthy males (c...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Lu Liu Source Type: research
Comparison of analgesic efficacy of ibuprofen and dexketoprofen in pain management of long bone fractures: a prospective, randomized, double-blind study
ConclusionIbuprofen 800 mg demonstrated superior analgesic efficacy at 60 and 120 min compared to Dex in long bone fractures. These findings suggest ibuprofen ’s potential as an effective pain management option in emergency departments. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - April 23, 2024 Category: Emergency Medicine Source Type: research
Which is Better in Predicting CT Scores in Patients with Chronic Rhinosinusitis after Medical treatment-Baseline Rhinosinusitis Disability Index (RSDI) or Endoscopic Score?
ConclusionStatistically significant (p < 0.001) association was found between baseline Lund-Kennedy endoscopic scores and Mackay-Lund CT scores post medical treatment. No significant association was found between RSDI scores and Mackay-Lund CT scores. ROC analysis indicated that Lund- Kennedy endoscopy score is a more accurate tool than RSDI score to predict a Mackay-Lund CT scores after medical treatment. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
Demand forecasting for platelet usage: From univariate time series to multivariable models
This study is the first to utilize different methods from statistical time series models to data-driven regression and machine learning techniques for platelet transfusion using clinical predictors and with different amounts of data. We find that the multivariable approaches have the highest accuracy in general, however, if sufficient data are available, a simpler time series approach appears to be sufficient. We also comment on the approach to choose predictors for the multivariable models. (Source: PLoS One)
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Maryam Motamedi Source Type: research
Prevalence and implications of bilateral and solely contralateral lymph node metastases in oral squamous cell carcinoma
ConclusionsB/SC LNMs are rare in patients with OSCC, especially in those who present with clinico-radiologically negative ipsilateral necks. Higher rates of B/SC metastases occur in case of advanced tumors and those localized at the upper jaw or floor of the mouth. Ipsilateral LNMs significantly elevate the risk of contralateral LNMs, tripling the associated risk.Clinical relevanceThese findings provide valuable insights for surgeons considering contralateral ND or extended adjuvant treatment for OSCC patients. However, the absence of high-level evidence from randomized controlled trials impedes the establishment of a defi...
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Rebleeding following aneurysmal subarachnoid hemorrhage before 'endovascular first treatment: a retrospective case-control study of published scoring systems
Conclusions
For aSAH patients treated in an ultra-early timeframe matched on size and parent vessel location, WFNS grade was superior to three published models for re-bleed prediction. Future re-bleed prediction models should incorporate the WFNS grade. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Dissanayake, A. S., Burrows, E., Ho, K. M., Phillips, T. J., Honeybul, S., Hankey, G. J. Tags: Hemorrhagic stroke Source Type: research
How well global dietary intake estimates agree: a case of sodium consumption
AbstractGlobal dietary data repositories are key components of nutrition surveillance. The two most comprehensive databases, the Global Dietary Database (GDD) and the Global Burden Disease (GBD), provide national dietary intake estimates but use different data sources and models to generate estimates. To explore the agreement between GDD and GBD estimates, we compared country-specific average daily sodium intakes in 169 countries over a 28-year period using descriptive statistics, the Bland –Altman method, and prevalence exceeding the intake reference level of 2.3 g/day. We detected a staggering 36% difference between G...
Source: Journal of Public Health Policy - April 23, 2024 Category: Health Management Source Type: research
Statewide Survey of Primary Care and Subspecialty Providers on Hepatocellular Carcinoma Risk-Stratification and Surveillance Practices
ConclusionsIn this statewide survey, there were great knowledge gaps in HCC surveillance among PCPs and most respondents expressed interest in strategies to increase appropriate HCC surveillance. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Efficacy of comprehensive structured exercise program on claudication pain and quality of life in type 2 diabetes mellitus with peripheral arterial disease
ConclusionIn the present study we found that comprehensive structured exercise program improves the arterial indices, quality of life, walking ability and reduces claudication pain in type 2 diabetes mellitus with peripheral arterial disease. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
The use of FreeStyle libre improves glycaemic control along with reducing diabetes burden and hospital admissions in a socially deprived Northwest English population
ConclusionThe use of FSL resulted in statistically significant reductions in hospital admissions, HbA1c and reported hypoglycaemic episodes among diabetics in a socially deprived Northwest region of England. These outcomes show a direct association with a higher questionnaire score. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Metabolomic Analysis of Human Cirrhosis and Hepatocellular Carcinoma: A Pilot Study
ConclusionOur findings give promising insides into the metabolic changes during HCC carcinogenesis and provide candidate biomarkers for future studies. Campesterol and furoylglycine in particular were identified as possible biomarkers for HCC progression. Moreover, eight metabolites were detected as predictors for poor overall survival.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Anterior versus posterior component separation technique for advanced abdominal wall reconstruction: a proposed algorithm
ConclusionFollowing a proposed algorithm, the anterior fascial closure rate was high and similar for both techniques. As postoperative wound morbidity is significantly increased after ACST, our findings support recommending TAR for defects up to 14 cm in width, while favoring open ACST for larger defects. (Source: Hernia)
Source: Hernia - April 23, 2024 Category: Sports Medicine Source Type: research
The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review
ConclusionWhite dot syndromes are very rare entities. Our findings highlight a possible association between COVID-19 vaccines and the occurrence of white dot syndromes. However, larger studies with good quality should be implemented to confirm these findings. (Source: International Ophthalmology)
Source: International Ophthalmology - April 23, 2024 Category: Opthalmology Source Type: research
