Comparing MicroRNA Profilings of Purified HER-2-Negative and HER-2-Positive Cells Validates miR-362-5p/Sema3A as Characteristic Molecular Change in Triple-Negative Breast Cancers.
Authors: Zhang X, He Q, Sun L, Zhang Y, Qin S, Fan J, Wang J Abstract Background: HER-2 is a key molecule serving as the therapeutic target, prognostic biomarker, and classification marker in breast cancer. Accurate microRNA profilings had not been conducted in purified tumor cells of HER-2-negative and HER-2-positive tissue specimens obtained from breast cancer patients. Methods: (i) Differential expression microRNA discovery using laser capture microdissection- (LCM-) assisted specimen preparation and microRNA array chips on HER-2 overexpressing and triple-negative breast carcinoma (TNBC) subtype tissues, (ii...
Source: Disease Markers - January 15, 2020 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Predictive value of metabolomic biomarkers for cardiovascular disease risk: a systematic review and meta-analysis.
CONCLUSION: This study provides evidence that metabolomic biomarkers, mainly lipid species, have the potential to provide additional prognostic value. Current data are promising, although approaches and results are heterogeneous. PMID: 31928240 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 15, 2020 Category: Research Tags: Biomarkers Source Type: research

A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease.
Conclusion: There was no significant improvement in the patient GERD symptoms increasing the dose of oral esomeprazole during the 6 months of study. N-of-1 trials in chronic pathologies including GERD are recommended due to their potential value as systematic methods that evaluate therapies without strong scientific evidence. PMID: 31929980 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - January 15, 2020 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Downregulation of long noncoding RNA SNHG14 suppresses cell proliferation and invasion by regulating EZH2 in pancreatic ductal adenocarcinoma (PDAC).
CONCLUSIONS: Thus, these results indicated that SNHG14 expression acts as a prognostic maker for PDAC and potential target of PDAC treatment. PMID: 31929143 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - January 15, 2020 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
In this study, we investigated casein kinase 2 alpha 1 (CSNK2A1) gene and protein expression in the liver tissues of mice at different ages (4, 16, and 32 weeks) using real-time quantitative polymerase chain reactions, western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay. Our data paved the way for exploring BKS.Cg- Dock7m +/+ Leprdb/JNarl in the mouse model by demonstrating a significant increase in gene and protein expression in T2DM (+Leprdb/+Leprdb) mouse liver when compared to control (+Dock7m/+Dock7m) mouse liver. We also observed that CSNK2A1 protein level in the serum of T2DM patient group ...
Source: International Journal of Medical Sciences - January 15, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Predictive Impact of Modified-Prognostic Nutritional Index for Acute Kidney Injury within 1-week after Living Donor Liver Transplantation.
Conclusions: The mPNI predicted AKI within 1-week better than other scoring systems in patients who underwent LDLT. The recommended cutoff value of mPNI is 8.7. PMID: 31929741 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - January 15, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.
Authors: Sun L, Qu L, Brigstock DR, Li H, Li Y, Gao R Abstract Human pancreatic stellate cells (PSCs) play a critical role in fibrogenesis during chronic pancreatitis (CP). However, primary PSCs have a short lifespan in vitro, which seriously affects their use in various applications. We have established a stable immortalized human PSC line (HP-1) by RSV promoter/enhancer-driven SV40 T antigen expression in primary activated human PSCs. HP-1 cells express cytoskeleton proteins including glial fibrillary acidic protein (GFAP), α-smooth muscle actin (α-SMA), vimentin and desmin, and are typical of PSCs, w...
Source: International Journal of Medical Sciences - January 15, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Treatment of Severe TRIcuspid Regurgitation in Patients with Advanced Heart Failure with CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL): a controlled prospective randomized trial.
CONCLUSIONS: CAVI did not result in a superior functional outcome compared to OMT. Due to an unexpectedly high rate of valve dislocations, the study was stopped for safety reasons. PMID: 31929100 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - January 15, 2020 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Minimum Meal Frequency Practice and Its Associated Factors among Children Aged 6-23 Months in Amibara District, North East Ethiopia.
Authors: Wagris M, Seid A, Kahssay M, Ahmed O Abstract Background: Minimum meal frequency, a proxy indicator for a child's energy requirements, examines the number of times children received foods other than breast milk. Without adequate diversity and meal frequency, infants and young children are vulnerable to malnutrition, especially stunting and micronutrient deficiencies, and increased morbidity and mortality. In Ethiopia, only 45% of children had fed with an age-appropriate minimum meal frequency. Objective: The study was aimed to assess the minimal meal frequency practice, and its associated factors among...
Source: Journal of Environmental and Public Health - January 15, 2020 Category: Environmental Health Tags: J Environ Public Health Source Type: research

A predictive failure framework for brittle porous materials via machine learning and geometric matching methods
AbstractBrittle porous materials are used in many applications, such as molten metal filter, battery, fuel cell, catalyst, membrane, and insulator. The porous structure of these materials causes variations in their fracture strength that is known as the mechanical reliability problem. Despite the importance of brittle porous materials, the origin of the strength variations is still unclear. The current study presents a machine learning approach to characterize the stochastic fracture of porous ceramics and glasses. A combined finite element modeling and fracture mechanics approach was used to generate a unique empirical da...
Source: European Journal of Applied Physiology - January 15, 2020 Category: Physiology Source Type: research

Comparison of Toxic Metal Concentrations in Antidiabetic Herbal Preparations (ADHPs) Available in Bangladesh Using AAS and XRF Analytical Tools.
Authors: Zamir R, Islam N, Faruque A Abstract Widespread escalation of type 2 diabetes is a concern throughout the world. Developing countries are leading with patients suffering from diabetes-related complications. Plant-based therapeutic, antidiabetic herbal preparations (ADHPs) are being sought for long and the consumption is increasing in in Bangladesh. Plant-based antidiabetic preparations do not go through the screening procedure in terms of safety. Toxic metals in ADHPs have been investigated by two different methods: atomic absorption spectroscopy (AAS) and X-ray fluorescence (XRF). Then, metal concentratio...
Source: The Scientific World Journal - January 15, 2020 Category: Science Tags: ScientificWorldJournal Source Type: research

Prevalence and Management of Hypokalemia in Peritoneal Dialysis Patients in Qatar.
Authors: Hamad A, Hussain ME, Elsanousi S, Ahmed H, Navalta L, Lonappan V, Alali F Abstract Introduction: Hypokalemia is common in patients undergoing peritoneal dialysis (PD). It is associated with increased cardiovascular and all-cause mortality. Treatment usually includes oral potassium supplements, which are poorly tolerated. Our aim was to evaluate the prevalence of hypokalemia in PD patients in Qatar and to improve treatment measures. Methods: All PD patients in Qatar with persistent hypokalemia and on potassium supplement were included. We performed a root cause analysis, and a management pathway was cre...
Source: International Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Statistical Methods and Software for Substance Use and Dependence Genetic Research.
Conclusion: In this article, we review statistical methods and software that are currently available for SUD genetic studies, and discuss their strengths and limitations. PMID: 31929725 [PubMed] (Source: Current Genomics)
Source: Current Genomics - January 15, 2020 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research

Characterizing photon number statistics using conjugate optical homodyne detection
We study the problem of determining the photon number statistics of an unknown quantum state using conjugate optical homodyne detection. We ... (Source: Optics Express)
Source: Optics Express - January 15, 2020 Category: Physics Authors: Bing Qi Pavel Lougovski Brian P. Williams Source Type: research

Tracking the polarisation state of light via Hong-Ou-Mandel interferometry
We provide a statistically robust and accurate framework to measure and track the polarisation state of light employing Hong-Ou-Mandel ... (Source: Optics Express)
Source: Optics Express - January 15, 2020 Category: Physics Authors: Natapon Harnchaiwat Feng Zhu Niclas Westerberg Erik Gauger Jonathan Leach Source Type: research

A two-year prospective study of injuries and illness in an elite national junior tennis program.
CONCLUSION: These findings can inform injury and illness preventative strategies to minimise absence from tennis play and should be prioritised in the under-16 group. Due to the different injury profile between males and females, tailored preventative programs should be developed for males and females individually. PMID: 31928289 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Source: The Physician and Sportsmedicine Online - January 15, 2020 Category: Sports Medicine Tags: Phys Sportsmed Source Type: research

Updated Nutrition Standards Have Significantly Improved the Nutritional Quality of School Lunches and Breakfasts
Publication date: Available online 13 January 2020Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Elizabeth C. Gearan, Mary Kay FoxAbstractBackgroundImplementation of updated nutrition standards for school meals began during school year (SY) 2012-2013. The standards were designed to improve the nutritional quality of the meals and their consistency with the Dietary Guidelines for Americans.ObjectiveTo assess the nutritional quality of school lunches and breakfasts after the updated standards were in place and compare it with the nutritional quality of the meals before the updated standards.DesignSchool ...
Source: Journal of the Academy of Nutrition and Dietetics - January 15, 2020 Category: Nutrition Source Type: research

Can BAI be better than BMI to estimate the increment of lumbar lordosis for Caucasians population?
Authors: Zwierzchowska A, Tuz J, Grabara M Abstract BACKGROUND: One of the complications of obesity is low back pain, frequently associated with postural disorders. Body adiposity index (BAI) can be calculated without weighing, which may be rendered useful in settings where measuring accurate body weight is problematic. OBJECTIVE: The aim of this study was to compare two indices of somatic structure, i.e., BAI and BMI regarding their accuracy (specific and sensitive) in predicting postural aberrations. METHODS: The study group comprised of 1281 participants aged 20-22 years, who were students from univ...
Source: Journal of Back and Musculoskeletal Rehabilitation - January 15, 2020 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

The identification of preliminary prognostic indicators that predict treatment response for exercise therapy in patients with nonspecific chronic low back pain: A multiple-arm cohort study design.
CONCLUSIONS: The most important variables were the prone instability test, pelvic tilt test, straight leg raise, body weight, visual analogue scale and the short form 36 health survey. PMID: 31929137 [PubMed - as supplied by publisher] (Source: Journal of Back and Musculoskeletal Rehabilitation)
Source: Journal of Back and Musculoskeletal Rehabilitation - January 15, 2020 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

Basophilia of the peripheral blood in patients with ulcerative colitis.
Conclusions: Our findings suggest that PBB represents an uncommon and not disease-specific laboratory feature of UC. It is not correlated with the CRP and may not represent a useful biomarker for disease monitoring in UC. PMID: 31928091 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - January 15, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Problems With Clinical Application of Low-Dose Vasopressin for Traumatic Hemorrhagic Shock —Reply
In Reply Thank you for your interest in our article, “Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock.” We believe Gauss et al have misread our statistical approach and are incorrectly interpreting the absolute standardized differences (ASD) as P values . There is a growing momentum to use P value alternatives, such as ASDs, in clinical research. Absolute standardized differences assess the magnitude of differences between groups (specifically, the absolute value of the difference in means, mean ranks, or proportions...
Source: JAMA Surgery - January 15, 2020 Category: Sports Medicine Source Type: research

Prevalence of Impacted Third Molars and The Reason for Extraction in Saudi Arabia
This study aims to record the current pattern of third molar impactions and relevant reasons for extraction in Riyadh, Saudi Arabia. We hypothesized that the principal reason for extraction was elective.Material and MethodsOrthopantomograms (OPG) radiographs and electronic files relating to 4000 patients were retrospectively collected from patients between the ages of 21 and 50 years old. Of these, 1014 were included in this study (514 females, 500 males). The classification was determined according to the Winter, Pell, and Gregory classification. The analysis was done using the chi-square (χ2) test, with SPSS version ...
Source: The Saudi Dental Journal - January 15, 2020 Category: Dentistry Source Type: research

Avoid Cohen's 'Small', 'Medium', and 'Large' for Power Analysis.
Abstract One of the most difficult and important decisions in power analysis involves specifying an effect size. Researchers frequently employ definitions of small, medium, and large that were proposed by Jacob Cohen. These definitions are problematic for two reasons. First, they are arbitrary, based on non-scientific criteria. Second, they are inconsistent, changing dramatically and illogically as a function of the statistical test a researcher plans to use (e.g., t-test versus regression). These problems may be unknown to many researchers, but they have a huge impact on power analyses. Estimates of the required ...
Source: Trends Cogn Sci - January 15, 2020 Category: Neuroscience Authors: Correll J, Mellinger C, McClelland GH, Judd CM Tags: Trends Cogn Sci Source Type: research

Advances in molecular simulations of protein mechanical properties and function.
r F Abstract Single-molecule force spectroscopy and classical molecular dynamics are natural allies. Recent advances in both experiments and simulations have increasingly facilitated a direct comparison of SMFS and MD data, most importantly by closing the gap between time scales, which has been traditionally at least 5 orders of magnitudes wide. In this review, we will explore these advances chiefly on the computational side. We focus on protein dynamics under force and highlight recent studies that showcase how lower loading rates and more statistics help to better interpret previous experiments and to also motiv...
Source: Current Opinion in Structural Biology - January 15, 2020 Category: Biology Authors: Franz F, Daday C, Gräter F Tags: Curr Opin Struct Biol Source Type: research

From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection.
Abstract Methods to detect signals of natural selection from genomic data have traditionally emphasized the use of simple summary statistics. Here, we review a new generation of methods that consider combinations of conventional summary statistics and/or richer features derived from inferred gene trees and ancestral recombination graphs (ARGs). We also review recent advances in methods for population genetic simulation and ARG reconstruction. Finally, we describe opportunities for future work on a variety of related topics, including the genetics of speciation, estimation of selection coefficients, and inference o...
Source: Trends in Genetics : TIG - January 15, 2020 Category: Genetics & Stem Cells Authors: Hejase HA, Dukler N, Siepel A Tags: Trends Genet Source Type: research

Left atrial diameter thresholds and new incident atrial fibrillation in embolic stroke of undetermined source.
Abstract BACKGROUND AND PURPOSE: We analyzed consecutive patients with embolic stroke of undetermined source (ESUS) from three prospective stroke registries to compare the prognostic performance of different LAD thresholds for the prediction of new incident AF. METHODS: We calculated the sensitivity, specificity, positive prognostic value (PPV), negative prognostic value (NPV) and Youden's J-statistic of different LAD thresholds to predict new incident AF. We performed multivariate stepwise regression with forward selection of covariates to assess the association between the LAD threshold with the highest You...
Source: European Journal of Internal Medicine - January 15, 2020 Category: Internal Medicine Authors: Perlepe K, Sirimarco G, Strambo D, Eskandari A, Karagkiozi E, Vemmou A, Koroboki E, Manios E, Makaritsis K, Vemmos K, Michel P, Ntaios G Tags: Eur J Intern Med Source Type: research

Effect of Different Musical Types on Patient's Relaxation, Anxiety and Pain Perception during Shock Wave Lithotripsy: A Randomized Controlled Study.
This study was a prospective single-blinded, paral-lel-group randomized clinical trial with balanced ran-domization [1:1]. A total of 150 patients who underwent first-session SWL were included in the study. The patients were randomly divided in to five groups (30 participants in each group) as follows: headphones were not put on and no music was played in Group 1 (control group); headphones were put on but no music was played in Group 2; Turkish art music was listened to with headphones in Group 3; Western classical music was listened to with headphones in Group 4; thetype of music the patient liked was listened to with he...
Source: Urology Journal - January 15, 2020 Category: Urology & Nephrology Authors: Çift A, Benlioglu C Tags: Urol J Source Type: research

Structural brain changes in young males addicted to video-gaming.
This study thus shows profound changes of brain structure as a function of excessive playing of violent video games. PMID: 31954233 [PubMed - as supplied by publisher] (Source: Brain and Cognition)
Source: Brain and Cognition - January 15, 2020 Category: Neurology Authors: Mohammadi B, Szycik GR, Te Wildt B, Heldmann M, Samii A, Münte TF Tags: Brain Cogn Source Type: research

Environmentally relevant exposures of male mice to carbendazim and thiram cause persistent genotoxicity in male mice.
Abstract Carbendazim and thiram are fungicides used in combination to prevent mold destruction of crops. Studies have demonstrated genotoxicity by these agents, but have not used concentrations below their water solubility limits in drinking water to test for persistence of genotoxicity due to chronic exposure. Ten 8-week old male Swiss-Webster mice were exposed to tap water, or nominal concentrations of 20 μM carbendazim, 20 μM thiram or 20 μM of both fungicides for 90 days (total of 40 mice). Five mice from tap water controls, carbendazim, thiram and combination-treated groups (20 mi...
Source: Environmental Science and Pollution Research International - January 15, 2020 Category: Environmental Health Authors: Rai B, Mercurio SD Tags: Environ Sci Pollut Res Int Source Type: research

Key considerations and challenges in the application of social-network research for environmental decision making.
This article is protected by copyright. All rights reserved. PMID: 31943349 [PubMed - as supplied by publisher] (Source: Conservation Biology)
Source: Conservation Biology - January 15, 2020 Category: Biology Authors: Guerrero AM, Barnes M, Bodin Ö, Chadès I, Davis KJ, Iftekhar MS, Morgans C, Wilson KA Tags: Conserv Biol Source Type: research

Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS.
Abstract Acute lung injury (ALI) is a clinically common and serious disease, underscoring the urgent need for clarification of its pathogenesis. According to traditional Chinese medicine (TCM) theories on the "lung-spleen-intestine axis" and its correlation with ALI, a high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS) metabolomic platform was applied to identify biomarkers from five bio-samples of control and model rats challenged with intratracheally administered lipopolysaccharide (LPS) based on multivariate mathematical statistical analysis. As a result,...
Source: Analytical and Bioanalytical Chemistry - January 15, 2020 Category: Chemistry Authors: Wang T, Lin S, Liu R, Li H, Liu Z, Zhang X, Xu H, Li Q, Bi K Tags: Anal Bioanal Chem Source Type: research

Lipidomic profiling of non-mineralized dental plaque and biofilm by untargeted UHPLC-QTOF-MS/MS and SWATH acquisition.
erhofer M Abstract Dental plaque is a structurally organized biofilm which consists of diverse microbial colonies and extracellular matrix. Its composition may change when pathogenic microorganisms become dominating. Therefore, dental biofilm or plaque has been frequently investigated in the context of oral health and disease. Furthermore, its potential as an alternative matrix for analytical purposes has also been recognized in other disciplines like archeology, food sciences, and forensics. Thus, a careful in-depth characterization of dental plaque is worthwhile. Most of the conducted studies focused on the scre...
Source: Analytical and Bioanalytical Chemistry - January 15, 2020 Category: Chemistry Authors: Drotleff B, Roth SR, Henkel K, Calderón C, Schlotterbeck J, Neukamm MA, Lämmerhofer M Tags: Anal Bioanal Chem Source Type: research

Effectiveness of Tocilizumab in Patients With Rheumatoid Arthritis is Unaffected by Comorbidity Burden or Obesity: Data From a US Registry.
This study evaluated TCZ effectiveness in treating RA patients with high versus low comorbidity burden and obesity versus non-obesity in US clinical practice. METHODS: Patients in the Corrona RA registry who initiated TCZ were stratified by low or high comorbidity burden using a modified Charlson Comorbidity Index (mCCI) and by obese or nonobese status using body mass index (BMI). Improvements in disease activity and functionality after TCZ initiation were compared for the aforementioned strata of patients at 6 and 12 months after adjusting for statistically significant differences in baseline characteristics. RE...
Source: J Rheumatol - January 15, 2020 Category: Rheumatology Authors: Pappas DA, Etzel CJ, Crabtree M, Blachley T, Best J, Zlotnick S, Kremer JM Tags: J Rheumatol Source Type: research

Reporting of Basic Statistical Methods in Biomedical Journals: Improved SAMPL Guidelines.
Abstract Statistical methods have become an essential component of all empirical biomedical research. Science requires that these methods are fully reported with complete accuracy so that the evidence base could be fully appraised for validity, reliability, and generalizability. To meet this objective, Statistical Analyses and Methods in Published Literature (SAMPL) guidelines have been prepared for statistical reporting in biomedical publications. This communication proposes substantial improvement of these guidelines to make them more comprehensive, organized, compact, and easier to adopt. PMID: 31937697 [P...
Source: Indian Pediatrics - January 15, 2020 Category: Pediatrics Authors: Indrayan A Tags: Indian Pediatr Source Type: research

Association of oral estradiol dose/levels with coagulation measures in early/late postmenopausal women.
This study evaluated associations of estradiol (E2) dose and serum E2 levels with coagulation/anti-coagulation measures in early (
Source: Climacteric - January 15, 2020 Category: Geriatrics Authors: Sriprasert I, Hodis HN, Bernick B, Mirkin S, Mack WJ Tags: Climacteric Source Type: research

Palatoscopy and odontometrics' potential role in sex determination among an adult Egyptian population sample: A pilot study.
Conclusions: Palatal rugae pattern, dental arch dimensions, and maxillary canine index can be considered as useful tools for sex determination in the forensic field. PMID: 31939990 [PubMed - as supplied by publisher] (Source: Homo)
Source: Homo - January 15, 2020 Category: Physiology Authors: Elrewieny NM, Ismail MME, Zaghloul HS, Abielhassan MH, Ali MM Tags: Homo Source Type: research

Improving anatomical stature estimation method. The relationship between living stature and intervertebral disc thickness.
Tuukkanen J Abstract Anatomical stature estimation methods reconstruct stature for skeletal specimens by adding up the heights of skeletal elements contributing to stature. In addition, these estimations factor in a certain amount of soft tissue known as "soft tissue correction". Our study focuses on the relationship between living stature and one of the major soft tissue contributors to stature: the intervertebral disc thickness/height. The purpose of this study was to clarify whether intervertebral disc thickness is greater in tall individuals and whether there is a linear correlation between stature a...
Source: Homo - January 15, 2020 Category: Physiology Authors: Junno JA, Oura P, Niskanen M, Väre T, Ruotsalainen M, Pietikäinen R, Niinimäki J, Nurminen N, Karppinen J, Auvinen J, Eriksson T, Tuukkanen J Tags: Homo Source Type: research

A Solution-Focused Coaching Intervention with Children and Youth with Cerebral Palsy to Achieve Participation-Oriented Goals.
Conclusions: SFC-peds may present an effective approach for working with children/youth with CP to achieve self-selected participation-oriented goals in a relatively short time-period. PMID: 31939337 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - January 15, 2020 Category: Physiotherapy Authors: Schwellnus H, King G, Baldwin P, Keenan S, Hartman LR Tags: Phys Occup Ther Pediatr Source Type: research

Dry Needling as a Treatment Modality for Tendinopathy: a Narrative Review
AbstractPurpose of ReviewTendinopathy describes a combination of pain, swelling, and impaired performance of the tendon and around structures. There are various treatment options for tendinopathy with unclear efficacy. Dry needling involves inserting needles into the affected tendon, and it is thought to disrupt the chronic degenerative process and encourage localized bleeding and fibroblastic proliferation. The purpose of this review is to review the use of dry needling as a treatment modality for tendinopathy.Recent FindingsThe effectiveness of dry needling for treatment of tendinopathy has been evaluated in 3 systematic...
Source: Current Reviews in Musculoskeletal Medicine - January 15, 2020 Category: Orthopaedics Source Type: research

Contribution of HLA ‐B*51:01 and ‐A*26:01 to Behçet's disease and their clinical association in Thai patients
ConclusionHLA ‐B*51:01 was a susceptible allele for Thai BD patients, and associated with posterior uveitis and visual impairment. HLA‐A*26:01 was another susceptible allele in HLA‐B*51X non‐carrier patients. The protective effect of HLA‐B*51:01 on arthritis needs further investigation. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - January 15, 2020 Category: Rheumatology Authors: Worawit Louthrenoo, Nuntana Kasitanon, Kessara Pathanapitoon, Suparaporn Wangkaew, Shoji Kuwata, Ai Nishi, Toshikatsu Kaburaki, Rie Tanaka, Fujio Takeuchi Tags: ORIGINAL ARTICLE Source Type: research

Physical Activity Compared to Adiposity and Risk of Liver-Related Mortality: Results from Two Prospective, Nationwide Cohorts
This is the first large, prospective cohort study to simultaneously evaluate the impact of obesity and physical activity on the long-term risk of liver-related mortality, in two nationwide populations of U.S. men and women. The study demonstrated that obesity predicted significantly increased risk of liver-related mortality, while physical activity predicted significantly lower risk of liver-related mortality. Importantly, the excess risk of liver-related mortality observed with obesity was no longer statistically significant among adults who engaged in the equivalent of average-pace walking for 3 hours or more, per week. ...
Source: Journal of Hepatology - January 15, 2020 Category: Gastroenterology Authors: Tracey G. Simon, Mi Na Kim, Xiao Luo, Wanshui Yang, Yanan Ma, Dawn Q. Chong, Charles S. Fuchs, Jeffrey A. Meyerhardt, Kathleen E. Corey, Raymond T. Chung, Meir Stampfer, Xuehong Zhang, Edward L. Giovannucci, Andrew T. Chan Source Type: research

The landscape of microbiota research in Iran; a bibliometric and network analysis
ConclusionsThe qualitative and quantitative information of this study will be a practical guidance for future study planning and policy-decision making. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - January 15, 2020 Category: Endocrinology Source Type: research

De novo variants in exomes of congenital heart disease patients identify risk genes and pathways
ConclusionsUltimately, these findings suggest novel genes that are likely to be contributing to CHD pathogenesis. (Source: Genome Medicine)
Source: Genome Medicine - January 15, 2020 Category: Genetics & Stem Cells Source Type: research

Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review
ConclusionsAlthough a slight tendency towards higher recession formation after SRP in combination with AB could be observed in many studies, quantitative meta-analyses showed no clinically relevant difference in recession formation due to the administration of AB. In general, the description and discussion of recessions in the literature seems not to be a major focus so far.Clinical relevanceSince the preservation of gingival tissues is important by preventive and therapeutic means, e.g., when avoiding postoperative root sensitivity or performing regenerative surgery, these aspects should not be neglected. We thus suggest ...
Source: Clinical Oral Investigations - January 15, 2020 Category: Dentistry Source Type: research

Clinical research tools in pediatric oncology: challenges and opportunities
AbstractSurvival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of c...
Source: Cancer and Metastasis Reviews - January 15, 2020 Category: Cancer & Oncology Source Type: research

Serum Level of HLDF24 Peptide as an Objective Marker of Prehypertension
The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (
Source: Bulletin of Experimental Biology and Medicine - January 15, 2020 Category: Biology Source Type: research

Associations of Intraoperative Radial Arterial Systolic, Diastolic, Mean, and Pulse Pressures with Myocardial and Acute Kidney Injury after Noncardiac Surgery A Retrospective Cohort Analysis
Editor ’s PerspectiveWhat We Already Know about This TopicArterial pressure is a complex signal that is characterized by three primary components — systolic, diastolic, and mean pressure, along with a derived component, pulse pressure (systolic minus diastolic pressure)Each blood pressure component reflects distinct hemodynamic variables, and therefore presumably differently influences perfusion of various organsPrevious work identifies associations between intraoperative systolic and mean hypotension with myocardial and kidney injuryWhat This Article Tells Us That Is NewFor each blood pressure component, the a...
Source: Anesthesiology - January 14, 2020 Category: Anesthesiology Source Type: research

Seroprevalence of cystic echinococcosis in the provinces of Ifrane and El Hajeb in Morocco.
CONCLUSION: Our results indicated a high prevalence and continuous transmission of hydatidosis in the provinces of Ifrane and El Hajeb of the Middle Atlas in Morocco. Mass screening campaigns are useful for evaluating the baseline prevalence, evolution of transmission, and risk factors for hydatidosis in endemic areas. PMID: 31928912 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - January 14, 2020 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

NMR-based metabolic profiling discriminates the geographical origin of raw sesame seeds
This study was performed to establish a discrimination model and investigate potential biomarkers for differentiating the geographical origin of sesame seeds from Korea, China, and other countries (India, Nigeria, and Ethiopia) by nuclear magnetic resonance -spectroscopy based metabolic profiling. A total of 24 polar metabolites in sesame seeds from 10, 6, and 4 samples of Korea, China, and other countries, respectively, were identified, and an orthogonal partial least squares-discriminant analysis model was established applying a total normalization and unit variance scaling method. Leave-one-out cross validation showed a...
Source: Food Control - January 14, 2020 Category: Food Science Source Type: research

Sensitivity analysis for the generalized shared-parameter model framework
(Source: Journal of Biopharmaceutical Statistics)
Source: Journal of Biopharmaceutical Statistics - January 14, 2020 Category: Statistics Authors: Iddrisu Gumedze Source Type: research