Prognostic Impact of Lymphoid Enhancer Factor 1 Expression and Serum Galectin.3 in Egyptian AML Patients.
Conclusion: We conclude that high LEF1 expression was a favorable prognostic marker which can define AML patient risk and outcome independent from assessing the serum galectin.3 level. PMID: 31929803 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - January 15, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience.
Authors: Bouchla A, Thomopoulos T, Papageorgiou S, Tsirigotis P, Bazani E, Gkirkas K, Vasilatou D, Glezou E, Stavroulaki G, Gkontopoulos K, Dimitriadis G, Pappa V Abstract The coexistence of a myeloid and a lymphoid neoplasm in the same patient is a rare finding. We retrospectively searched the records of the Hematology Division of the Second Department of Internal Medicine and Research Institute at Attikon University General Hospital of Athens from 2003 to 2018. Nine cases have been identified in a total of 244 BCR-/ABL1- negative MPN and 25 MDS/MPN patients and 1062 LPD patients referred to our institution betwee...
Source: Advances in Hematology - November 30, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine.
Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization. PMID: 31781225 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - November 30, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence of Anemia and Associated Factors among Newly Diagnosed Patients with Solid Malignancy at Tikur Anbessa Specialized Hospital, Radiotherapy Center, Addis Ababa, Ethiopia.
Authors: Kifle E, Hussein M, Alemu J, Tigeneh W Abstract Background: Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients, worsens disease status and impairs treatment outcome; however, little is known about the prevalence of anemia and associated factors among cancer patients during diagnosis in developing countries like Ethiopia. In response to this, we have conducted research with the aim of assessing the prevalence of anemia and associated factors among newly diagnosed patients with solid malignancy at Tikur Anbessa Specialized Hospital (TASH...
Source: Advances in Hematology - November 30, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Management of Adult Patients with Primary Immune Thrombocytopenia (ITP) in Clinical Practice: A Consensus Approach of the Spanish ITP Expert Group.
Authors: Mingot-Castellano ME, Román MTÁ, Fernández Fuertes LF, González-López TJ, Guinea de Castro JM, Jarque I, López-Fernández MF, Lozano ML, Sánchez González B, Ferreiras DV, González Porras JR Abstract Background and Objective: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP. Ma...
Source: Advances in Hematology - September 21, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Corrigendum to "Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update".
Corrigendum to "Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update". Adv Hematol. 2019;2019:4120631 Authors: Villafuerte-Gutierrez P, Villalon L, Losa JE, Henriquez-Camacho C Abstract [This corrects the article DOI: 10.1155/2014/986938.]. PMID: 31379947 [PubMed - in process] (Source: Advances in Hematology)
Source: Advances in Hematology - August 7, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Quantifying the Levels of Knowledge, Attitude, and Practice Associated with Sickle Cell Disease and Premarital Genetic Counseling in 350 Saudi Adults.
Authors: Al-Qattan HM, Amlih DF, Sirajuddin FS, Alhuzaimi DI, Alageel MS, Bin Tuwaim RM, Al Qahtani FH Abstract Our study aims to observe the levels of knowledge, attitude, and practice (KAP) associated with sickle cell disease (SCD) and premarital genetic counseling (PMGC) in 351 Saudi adults. The relationships between KAP levels and sociodemographic characteristics (age, gender, marital status, and educational level) were observed. The study was conducted in King Khalid University Hospital between February 21, 2017, and March 7, 2018. A total of 351 Saudi participants attending the primary care clinic were select...
Source: Advances in Hematology - June 13, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Lung Function Abnormalities in Sickle Cell Anaemia.
Authors: Dei-Adomakoh YA, Afriyie-Mensah JS, Forson A, Adadey M, Ndanu TA, Acquaye JK Abstract Background: Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sickle cell cohort. There is generally little information available on risk factors associated with the lung function abnormalities and its relevance in patient care. Method: This was an analytical cross-sectional study involv...
Source: Advances in Hematology - May 7, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Loxoscelism: Cutaneous and Hematologic Manifestations.
Conclusion: Treatment of systemic loxoscelism involves aggressive supportive care including appropriate wound management, blood transfusions, intravenous fluid replacement, and appropriate antibiotic coverage. It is unclear at this time if glucocorticoids or IVIg has any beneficial impact on the treatment of severe loxoscelism. PMID: 31015839 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 26, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Factors Associated with Anemia among People Living with HIV/AIDS Taking ART in Ethiopia.
Conclusions: About one in three patients was found to be anemic. Intervention aimed at diagnosing and treating anemia among people living with HIV/AIDS should be considered. PMID: 30941180 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 5, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia.
Authors: Eleutério RMN, Nascimento FO, Araújo TG, Castro MF, Filho TPA, Filho PAM, Eleutério J, Elias DBD, Lemes RPG Abstract Background: Sickle cell anaemia (SCA) is the most prevalent monogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, which modifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) synthesis. SCA treatment uses hydroxyurea (HU) to maintain h...
Source: Advances in Hematology - March 13, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Real-World Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Relapsed or Refractory Multiple Myeloma: Evidence from a Medical Record Review in France.
Conclusions: The prognostic importance of cytogenetic risk in RRMM was apparent, whereby high (versus standard) risk patients had decidedly shorter PFS and OS. Frequent hospitalizations indicated potentially high costs associated with RRMM, particularly for high risk patients. These findings may inform economic evaluations of RRMM therapies. PMID: 30838045 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - March 8, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Effect of Imatinib on Bone Marrow Morphology and Angiogenesis in Chronic Myeloid Leukemia.
This study was done to assess the effect of imatinib on bone marrow morphology and angiogenesis in CML. Methods: 31 newly diagnosed CML patients were evaluated before and after 3 months of imatinib therapy. A marrow morphological response (MMR) score was used to assess marrow cytological and histological features including grade of fibrosis. Mean microvessel density (MVD) was also assessed. Hematological parameters and BCR-ABL transcript levels were assessed in the peripheral blood. Results: 86.21% of patients showed decrease in marrow cellularity with normalization of M:E ratio. 72.42% of patients had decrease in ...
Source: Advances in Hematology - February 5, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Traceability of Blood Transfusions and Reporting of Adverse Reactions in Developing Countries: A Six-Year Postpilot Phase Experience in Burkina Faso.
Authors: Sawadogo S, Nebie K, Millogo T, Sontie S, Nana A, Dahourou H, Yonli DY, Tapko JB, Faber JC, Kafando E, Deneys V Abstract Traceability is an essential tool for haemovigilance and transfusion safety. In Burkina Faso, the implementation of haemovigilance has been achieved as part of a pilot project from 2005 to 2009. Our study aims to evaluate the traceability of blood transfusions and reporting of adverse reactions over the 6-year postpilot phase. A cross-sectional study including all blood units ordered between 2010 and 2015 has been conducted in public and private health care facilities supplied with blood...
Source: Advances in Hematology - January 25, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Burden of Sickle Cell Disease in Ghana: The Korle-Bu Experience.
Authors: Asare EV, Wilson I, Benneh-Akwasi Kuma AA, Dei-Adomakoh Y, Sey F, Olayemi E Abstract In Africa, sickle cell disease (SCD) is a major public health problem with over 200,000 babies born per year. In Ghana, approximately 15,000 (2%) of Ghanaian newborns are diagnosed with SCD annually. A retrospective review of medical records of all SCD patients aged 13 years and above, who presented to the sickle cell clinic at Ghana Institute of Clinical Genetics (GICG), Korle-Bu, from 1st January 2013 to 31st December 2014, was carried out, using a data abstraction instrument to document their phenotypes, demographics, a...
Source: Advances in Hematology - January 12, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

A Novel Approach for Objective Assessment of White Blood Cells Using Computational Vision Algorithms.
Authors: Rodríguez Barrero CM, Romero Gabalan LA, Roa Guerrero EE Abstract In the field of medicine, the analysis of blood is one of the most important exams to determine the physiological state of a patient. In the analysis of the blood sample, an important process is the counting and classification of white blood cells, which is done manually, being an exhaustive, subjective, and error-prone activity due to the physical fatigue that generates the professional because it is a method that consumes long laxes of time. The purpose of the research was to develop a system to identify and classify blood cells, by...
Source: Advances in Hematology - December 13, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes.
Authors: Chokr N, Patel R, Wattamwar K, Chokr S Abstract Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and a wide spectrum of manifestations ranging from indolent and asymptomatic cytopenias to acute myeloid leukemia (AML). MDS result from genetic and epigenetic derangements in clonal cells and their surrounding microenvironments. Studies have shown associations between MDS and other autoimmune diseases. Several immune mechanisms have been identified in MDS, suggesting that immune dysregulation might be at least partially implicated in its pathogene...
Source: Advances in Hematology - December 7, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes.
Authors: Dudina GA, Donetskova AD, Litvina MM, Mitin AN, Mitina TA, Polyakov SA Abstract We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking ...
Source: Advances in Hematology - November 10, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients.
Authors: Hamdy M, Salama N, Maher G, Elrefaee A Abstract Lower levels of vitamin D have been documented in many patients with sickle cell disease (SCD), but data are still inconclusive regarding the association between vitamin D deficiency (VDD) and the occurrence or the severity of various SCD complications. Our study aimed to detect the prevalence of vitamin D deficiency among Egyptian patients with SCD and to associate it with the clinical course of the disease. We measured the level of 25-hydroxy vitamin D in 140 children (age from 4.3 to 15.5years), 80 patients with SCD and 60 controls using enzyme-linked immu...
Source: Advances in Hematology - October 13, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence and Factors Associated with Anemia among Pregnant Women Attending Antenatal Clinic at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Conclusion: In this study the prevalence of anemia in pregnancy was low compared to the findings of others. Gestational age (trimester) and iron/folic acid supplementation were statistically associated with anemia. Therefore, iron supplementation and health education to create awareness about the importance of early booking for antenatal care are recommended to reduce anemia. PMID: 30245724 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - September 26, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests.
Conclusion: Despite statistically significant changes in RBC parameters such as MCV, RDW, and MCHC and platelet count, these changes were clinically insignificant. Hence, blood samples for CBC and coagulation assay can safely be transported via our hospital's PTS. However, further studies on platelet count are warranted to ensure safe transport and accuracy of the results. PMID: 30079089 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - August 8, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine.
Conclusions: RBC alloimmunization rate among Palestinian SCD patients is low compared to neighboring countries and countries all over the world but still warrants more attention. Phenotyping of donors/recipients' RBC for Rh antigens and K1 (partial phenotype matching) before their first transfusion may reduce the incidence of alloimmunization. PMID: 29977298 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - July 8, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence of Bleeding Symptoms among Adolescents and Young Adults in the Capital City of Saudi Arabia.
Conclusion: In this study, we report for the first time the prevalence of bleeding symptoms in a representative sample of Saudi adolescents and young adults. PMID: 29853900 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 2, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma.
Conclusion: Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup. PMID: 29692812 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 26, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Impact of Age on Outcomes in Hospitalized Patients with Hereditary Hemorrhagic Telangiectasia.
Conclusion: Aging has significant adverse impacts on rates of hospitalization, complications, and outcomes amongst HHT patients in the United States. Except for neurologic complications, the vast majority of this disease burden is borne by patients older than 50 years. PMID: 29610574 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 5, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis.
Authors: Makis A, Gkoutsias A, Palianopoulos T, Pappa E, Papapetrou E, Tsaousi C, Hatzimichael E, Chaliasos N Abstract Immune thrombocytopenia (ITP) in children has a varied course and according to duration is distinguished as newly diagnosed (12) types. Several studies have evaluated the prognostic factors for the progression of the disease, but similar works have yet to be performed in Greece. We aimed to identify prognostic markers for the three forms of the disease in 57 Greek children during a 13-year period. Information regarding age, gender, preceding infection, bleeding type, duration of symptoms and platel...
Source: Advances in Hematology - January 26, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy.
Authors: Farhan S, Bazydlo M, Neme K, Mikulandric N, Peres E, Janakiraman N Abstract In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu pharmacokinetics (Bu PK) and those who received busulfan with cyclophosphamide (BuCy). Fifty-five patients received FluBu4, of whom 21 had Bu PK measured, and 23 patients received BuCy. Total donor cell chimerism showed that the percentage of patients maintaining 100% donor chimerism on ...
Source: Advances in Hematology - December 20, 2017 Category: Hematology Tags: Adv Hematol Source Type: research

Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients.
Authors: Ait-Tahar K, Anderson AP, Barnardo M, Collins GP, Hatton CSR, Banham AH, Pulford K Abstract Improved therapies are urgently needed for patients with diffuse large B cell lymphoma (DLBCL). Success using immune checkpoint inhibitors and chimeric antigen receptor T cell technology has fuelled demand for validated cancer epitopes. Immunogenic cancer testis antigens (CTAs), with their widespread expression in many tumours but highly restricted normal tissue distribution, represent attractive immunotherapeutic targets that may improve treatment options for DLBCL and other malignancies. Sperm protein 17 (Sp17), a...
Source: Advances in Hematology - December 7, 2017 Category: Hematology Tags: Adv Hematol Source Type: research

Study of Erythrocyte Indices, Erythrocyte Morphometric Indicators, and Oxygen-Binding Properties of Hemoglobin Hematoporphyrin Patients with Cardiovascular Diseases.
Authors: Revin VV, Ushakova AA, Gromova NV, Balykova LA, Revina ES, Stolyarova VV, Stolbova TA, Solomadin IN, Tychkov AY, Revina NV, Imarova OG Abstract The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting disorders are observed. Standard therapy does not result in the restoration of the structu...
Source: Advances in Hematology - August 12, 2017 Category: Hematology Tags: Adv Hematol Source Type: research

Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia.
We present a retrospective review of 26 consecutive patients with RR-AML receiving single agent cytarabine 3 g/m(2) intravenously every 12 hours on days 1, 3, and 5 for a total of six doses (HiDAC-6). Median follow-up for surviving patients was 10.4 months (range 1.6-112.2 months). Complete remission was obtained in 62% (54% CR and 8% CRi) of the patients. The median relapse-free survival (RFS) was 22.3 months (range 0.7-112 months), event-free survival (EFS) was 4.7 months (range 0.5-112 months), and the overall survival (OS) was 9.6 months (range 1-112 months). Thirty-five percent of patients were able to subseque...
Source: Advances in Hematology - June 9, 2017 Category: Hematology Tags: Adv Hematol Source Type: research

Efficacy and Safety of Manual Partial Red Cell Exchange in the Management of Severe Complications of Sickle Cell Disease in a Developing Country.
CONCLUSION: This work shows the feasibility of manual partial RCE in a low-resource setting and its efficacy and safety during complications of SCD outside of acute priapism. PMID: 28584527 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 8, 2017 Category: Hematology Tags: Adv Hematol Source Type: research

The Evolution of Prognostic Factors in Multiple Myeloma.
We present this comprehensive review to summarize the current standard prognostic markers used in MM along with novel techniques that are still in development and highlight their implications in current clinical practice. PMID: 28321258 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - March 24, 2017 Category: Hematology Tags: Adv Hematol Source Type: research

Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana.
Conclusion. Screening for red cell pathologies must be incorporated into existing protocols for populations with high incidence of haemoglobinopathies to protect high-risk recipients. PMID: 27703480 [PubMed - in process] (Source: Advances in Hematology)
Source: Advances in Hematology - October 7, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Autologous Graft-versus-Tumor Effect: Reality or Fiction?
Authors: Porrata LF Abstract In contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell transplantation only relies on the high-dose chemotherapy to improve clinical outcomes. However, recent studies argue in favor of the existence of an autologous graft-versus-tumor without the detrimental complications of graft-versus-host disease due to the nonspecific immune response from the infused donor alloreactive immune effector cells i...
Source: Advances in Hematology - September 19, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Haploidentical Family Donor Transplantation: At the Crossroads of a Changing Paradigm.
Authors: Chakrabarti S, Aversa F, Reisner Y, O'Donnell P PMID: 27340406 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 26, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies.
Authors: Parmesar K, Raj K Abstract Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis. This ...
Source: Advances in Hematology - June 18, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Clinical Scenarios for Discordant Anti-Xa.
Conclusions and Relevance. To our knowledge this is the first paper that summarizes the most common causes in which this assay can be affected, several "day to day" clinical scenarios can modify the outcomes, and we concur that these rarely recognized scenarios can be affected by negative outcomes in the daily practice. PMID: 27293440 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 15, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Combined Bone Marrow and Kidney Transplantation for the Induction of Specific Tolerance.
Authors: Chen YB, Kawai T, Spitzer TR Abstract The induction of specific tolerance, in order to avoid the detrimental effects of lifelong systemic immunosuppressive therapy after organ transplantation, has been considered the "Holy Grail" of transplantation. Experimentally, tolerance has been achieved through clonal deletion, through costimulatory blockade, through the induction or infusion of regulatory T-cells, and through the establishment of hematopoietic chimerism following donor bone marrow transplantation. The focus of this review is how tolerance has been achieved following combined bone marrow an...
Source: Advances in Hematology - May 31, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

HLA Haplotype Mismatch Transplants and Posttransplant Cyclophosphamide.
Authors: Bacigalupo A, Sica S Abstract The use of high dose posttransplant cyclophosphamide (PT-CY) introduced by the Baltimore group approximately 10 years ago has been rapidly adopted worldwide and is becoming a standard for patients undergoing unmanipulated haploidentical (HAPLO) transplants. PT-CY has been used following nonmyeloablative as well as myeloablative conditioning regimens, for bone marrow or peripheral blood grafts, for patients with malignant and nonmalignant disorders. Retrospective comparisons of HAPLO grafts with conventional sibling and unrelated donor grafts have been published and suggest com...
Source: Advances in Hematology - May 6, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Choice of Unmanipulated T Cell Replete Graft for Haploidentical Stem Cell Transplant and Posttransplant Cyclophosphamide in Hematologic Malignancies in Adults: Peripheral Blood or Bone Marrow-Review of Published Literature.
Authors: Farhan S, Peres E, Janakiraman N Abstract Allogeneic hematopoietic stem cell transplantation (SCT) is often the only curative option for many patients with malignant and benign hematological stem cell disorders. However, some issues are still of concern regarding finding a donor like shrinking family sizes in many societies, underrepresentation of the ethnic minorities in the registries, genetic variability for some races, and significant delays in obtaining stem cells after starting the search. So there is a considerable need to develop alternate donor stem cell sources. The rapid and near universal avail...
Source: Advances in Hematology - April 28, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues.
Authors: Jaiswal SR, Chakrabarti S Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia. Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched umbilical cord blood (UCB) are viable options, they fail to meet the global need. Haploidentical family donor is almost universally available and is emerging as the alternate donor of choice in adult patients. However, the same is not true in the case of children. The studies of haploidentical HSCT in children are largely limite...
Source: Advances in Hematology - April 27, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Retracted: Plasmablastic Lymphoma: A Review of Current Knowledge and Future Directions.
Authors: In Hematology A Abstract [This retracts the article DOI: 10.1155/2015/315289.]. PMID: 27110244 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 27, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Review on Haploidentical Hematopoietic Cell Transplantation in Patients with Hematologic Malignancies.
We present here a summary and review of the latest results of these studies as well as a brief discussion on the advantages and challenges of haploidentical HSCT. PMID: 27034676 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 3, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Biochemical Markers of Bone Turnover in Patients with ╬▓-Thalassemia Major: A Single Center Study from Southern Pakistan.
Conclusions. Biochemical profile is significantly altered in patients with β-thalassemia major and bone associated biochemical abnormalities like hypocalcaemia, 25-OH vitamin D deficiency, and hypophosphatemia are not uncommon in Pakistani patients with thalassemia major. PMID: 27006658 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - March 25, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph.
Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph. Adv Hematol. 2016;2016:7678901 Authors: Monroe DM, Jenny RJ, Van Cott KE, Buhay S, Saward LL Abstract The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dichroism, and gel filtration were used to determine purity and confirm structure. Chromatographic and mass spectrom...
Source: Advances in Hematology - March 23, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt.
Conclusion. The frequency of TTIs, especially HCV, is considerably high among Egyptian children with thalassemia major. It is therefore important to implement measures to improve blood transfusion screening, such as polymerase chain reaction, in order to reduce TTIs from blood donor units. PMID: 26989417 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - March 20, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana.
Authors: Afoakwah R, Aubyn E, Prah J, Nwaefuna EK, Boampong JN Abstract The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group "A" have been found to be highly susceptible to falciparum malaria whereas blood group "O" is said to confer protection against complicated cases. We analyzed samples from 293 young children less than six years old with malaria in th...
Source: Advances in Hematology - March 17, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Haploidentical Hematopoietic Stem Cell Transplantation: Expanding the Horizon for Hematologic Disorders.
Authors: Zahid MF, Rizzieri DA Abstract Despite the advent of targeted therapies and novel agents, allogeneic hematopoietic stem cell transplantation remains the only curative modality in the management of hematologic disorders. The necessity to find an HLA-matched related donor is a major obstacle that compromises the widespread application and development of this field. Matched unrelated donors and umbilical cord blood have emerged as alternative sources of donor stem cells; however, the cost of maintaining donor registries and cord blood banks is very high and even impractical in developing countries. Almost eve...
Source: Advances in Hematology - March 8, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Influence of Oxidative Stress on Stored Platelets.
Authors: Manasa K, Vani R Abstract Platelet storage and its availability for transfusion are limited to 5-6 days. Oxidative stress (OS) is one of the causes for reduced efficacy and shelf-life of platelets. The studies on platelet storage have focused on improving the storage conditions by altering platelet storage solutions, temperature, and materials. Nevertheless, the role of OS on platelet survival during storage is still unclear. Hence, this study was conducted to investigate the influence of storage on platelets. Platelets were stored for 12 days at 22°C. OS markers such as aggregation, superoxides, react...
Source: Advances in Hematology - March 8, 2016 Category: Hematology Tags: Adv Hematol Source Type: research

Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation.
Authors: Kongtim P, Cao K, Ciurea SO Abstract Outcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA-half matched related donors (haploidentical) have recently improved due to better control of alloreactive reactions in both graft-versus-host and host-versus-graft directions. The recognition of the role of humoral rejection in the development of primary graft failure in this setting has broadened our understanding about causes of engraftment failure in these patients, helped us better select donors for patients in need of AHSCT, and developed rational therapeutic measures for HLA sensitize...
Source: Advances in Hematology - February 25, 2016 Category: Hematology Tags: Adv Hematol Source Type: research