Assessing the Performance of Extended Half-Life Coagulation Factor VIII, FC Fusion Protein by Using Chromogenic and One-Stage Assays in Saudi Hemophilia A Patients.
This study aimed to assess the discrepancy and correlation between the chromogenic and one-stage assays in measuring FVIII : C levels in hemophilia patients receiving Extended Half-Life Elocta® as a recombinant extended half-life coagulation factor. Methods: We performed a study comparing the measurements of FVIII : C levels by the chromogenic versus the one-stage assays at different drug levels. Data of FVIII : C levels, dosage, and the time interval from administration to measurement were retrieved from the hospital records. The correlation, mean differences, and discrepa...
Source: Advances in Hematology - September 25, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Comediation of Erythrocyte Haemolysis by Erythrocyte-Derived Microparticles and Complement during Malaria Infection.
Conclusion. At a fixed volume of 50 μL complement, there were statistically significant (p
Source: Advances in Hematology - September 13, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Demographics of Rhesus Phenotype of Blood Donors in Calabar: A Case Study of University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
Conclusion: This work therefore concludes that the most prevalent rhesus antigen and rhesus phenotype was c and cDe/cDe among blood donors in University of Calabar Teaching Hospital. PMID: 32908516 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - September 13, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome.
Authors: Klouda T, Raybagkar D, Bernstein B, Apollonsky N Abstract Close to half of all patients with sickle cell disease (SCD) will have at least one episode of acute chest syndrome (ACS) during their lifetime. Multiple cells and molecules involved with the inflammatory cascade play a role in the development of ACS. We found that patients with SCD who developed ACS as a complication of a vaso-occlusive crisis (VOC) had a significant increase in leukocytes and decrease in platelets from their steady state when compared with a separate admission for VOC without ACS development. No significant change from steady stat...
Source: Advances in Hematology - September 13, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Alopecia and Iron Deficiency: An Interventional Pilot Study in Primary Care to Improve the Request of Ferritin.
Conclusion: Primary care patients with alopecia and laboratory tests request were mainly young female. Our intervention added ferritin when not requested, detecting iron deficiency in 27.9% of women, potentially avoiding the adverse effects of iron deficiency on hair loss. PMID: 32908518 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - September 13, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Assessment of Confirmed Clinical Hypersensitivity to Rituximab in Patients Affected with B-Cell Neoplasia.
Conclusions. The 12-step desensitization protocol is very effective and assumable within healthcare practice. There is a need to determine the mechanism underlying the infusion reaction in a large proportion of cases due to the risk of future drug exposure. PMID: 32577119 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 25, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Blood Donors' Age, Haemoglobin Type, G6PD Status, and Blood Group Impact Storability of CPDA-1 Banked Whole Blood: A Repeated-Measure Cohort Study in Cape Coast, Ghana.
This study investigated the impact that inherited haemoglobin variants and/or G6PD status have on whole blood banked at 4-6°C for 35 days. Method: This repeated-measure cohort study was undertaken on 103 donor blood units collected into blood bag containing CPDA-1 anticoagulant. On days 0, 7, 14, 21, and 35, full blood count, osmotic-induced haemolysis, and plasma K+ levels were estimated. Also, on day 0, G6PD status, haemoglobin variants, % foetal haemoglobin, and blood group of donor units were determined using methaemoglobin reductase, cellulose acetate electrophoresis, modified Bekte alkali denaturation assay, ...
Source: Advances in Hematology - June 21, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese.
Authors: Doucette K, Latif H, Vakiti A, Tefera E, Patel B, Fitzpatrick K Abstract Obesity plays an essential role in the safety of pharmacologic drugs. There is paucity of data for direct oral anticoagulants (DOACs) in the obese, despite these agents becoming more widely used. The primary and secondary objectives of this study were to assess the safety and efficacy of DOACs in the overweight and obese populations when used for primary prophylaxis in the setting of non-valvular atrial fibrillation (NVAF) and for treatment of venous thromboembolisms (VTE). We conducted a retrospective cohort study in a large tertiary...
Source: Advances in Hematology - June 14, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients.
In conclusion, CD25+/CD123+ positive coexpression is a reliable flow cytometry marker for prediction of the outcome of adult B-ALL patients and could be used as a novel parameter for risk stratification of adult B-ALL cases. PMID: 32518561 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 11, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course.
Conclusion: Monocytopenia, especially anemia, was the most common type of cytopenia. The cytopenia was predominantly grade 2, developed in majority of the patients within 6 months after imatinib initiation, and had resolved by 24-36 months after imatinib initiation. PMID: 32454829 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - May 28, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Blood Management and Risk Assessment for Transfusion in Pediatric Spinal Deformity Surgery.
Authors: Fernandes P, Soares do Brito J, Flores I, Monteiro J Abstract Objectives: Evaluate the impact of a Quality and Safety Program (QSP) on the reduction of blood loss and transfusion needs in pediatric spinal deformity surgery, while defining risk factors for transfusion. Background: Multimodal plan aiming to minimize transfusion needs has been shown to reduce transfusions and index rates in spinal deformity surgery. Anticipating blood loss and transfusion may help direct resources to patient needs or encourage reconsideration of the surgical plan. Methods: This is a single-center retrospective study o...
Source: Advances in Hematology - May 28, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study.
Authors: Schmalz G, Tulani L, Busjan R, Haak R, Kottmann T, Trümper L, Hasenkamp J, Ziebolz D Abstract This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients' records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as...
Source: Advances in Hematology - May 8, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Deletional Alpha-Thalassemia Alleles in Amazon Blood Donors.
In this study, the subjects were screened for -α 3.7/4.2/20.5, -SEA, -FIL, and -MED deletions. Alpha-thalassemia screening was carried out between 2016 and 2017 among 714 (72.1%) male and 275 (27.9%) female donors. The aims of this analysis were to describe the distribution of various alpha-thalassemia alleles by gender, along with their genotypic interactions, and to illustrate the hematological changes associated with each phenotype. Amongst the patients, 5.35% (n = 53) were diagnosed with deletion -α -3.7 and only one donor with α -4.2 deletion. From the individuals with -α -3.7, 85...
Source: Advances in Hematology - May 2, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Thrombophilic Risk of Factor V Leiden, Prothrombin G20210A, MTHFR, and Calreticulin Mutations in Essential Thrombocythemia Egyptian Patients.
Conclusion: There is a significant increase risk of thrombosis in ET patients with CALR mutation, thrombophilic mutations, as well as factor V Leiden and prothrombin gene mutation with a risk of developing leukemic transformation. PMID: 32292481 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 16, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors.
Authors: Mancuso S, Accurso V, Santoro M, Raso S, Contrino AD, Perez A, Di Piazza F, Florena AM, Russo A, Siragusa S Abstract Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong. Different thrombotic risk scores for patients with essential thrombocythemia have been proposed, but only one of them (the IPSET-t scoring system) takes into account the classical cardiovascular risk factors as one of the scoring items. Currently, in clinical practice, the presence of cardiovascular risk factors in patients w...
Source: Advances in Hematology - April 15, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study.
Conclusion: Patients receiving health care at the Ho Teaching Hospital had different hemoglobin variants with HbAS recording the highest prevalence. The high incidence of hemoglobin AS implies the possibility of having an increased population of individuals with sickle cell disease in future if measures are not put in place to improve screening, counseling, and education of the public about the health threat SCD poses. PMID: 32256599 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 9, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon.
Authors: Kubong LN, Nya Biapa PC, Chetcha B, Yanou-Njintang N, Moor Ama VJ, Pieme CA Abstract Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017. After informed co...
Source: Advances in Hematology - April 9, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence of Anemia and Its Associated Factors in Antiretroviral-Treated HIV/AIDS-Positive Adults from 2013 to 2018 at Debre Berhan Referral Hospital, Ethiopia.
Authors: Aynalem YA, Shibabaw Shiferaw W, Woldiye Z Abstract Introduction. Anemia was defined as a hemoglobin level of less than or equal to 13.9 g/dl for male and less than or equal to 12.2 g/dl for female adults. It is one of the most common hematological abnormalities in people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and is a determining factor for disease progression and death. Among the countries in sub-Saharan Africa, Ethiopia is one of the most affected nations by HIV. Therefore, this study aimed to assess the prevalence of anemia and its associate...
Source: Advances in Hematology - April 2, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

An Update on the Reversal of Non-Vitamin K Antagonist Oral Anticoagulants.
Authors: Mujer MTP, Rai MP, Atti V, Dimaandal IL, Chan AS, Shrotriya S, Gundabolu K, Dhakal P Abstract Non-vitamin K antagonist oral anticoagulants (NOACs) include thrombin inhibitor dabigatran and coagulation factor Xa inhibitors rivaroxaban, apixaban, edoxaban, and betrixaban. NOACs have several benefits over warfarin, including faster time to the achieve effect, rapid onset of action, fewer documented food and drug interactions, lack of need for routine INR monitoring, and improved patient satisfaction. Local hemostatic measures, supportive care, and withholding the next NOAC dose are usually sufficient to achie...
Source: Advances in Hematology - April 2, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Laboratory Biomarkers, Cerebral Blood Flow Velocity, and Intellectual Function in Children with Sickle Cell Disease.
Conclusions: In addition to effects of age and maternal education, some vasculopathic markers are associated with cognitive function in young children with SCD, and these relationships do not appear to be mediated through blood flow velocity. Although the lack of association among certain variables was not as predicted, results provide support for further research regarding the influence of vasculopathic markers on cognitive function in children with SCD without stroke, especially intravascular hemolysis and coagulation/endothelial activation, and a possible role for HU treatment in preventing or reversing cognitive declin...
Source: Advances in Hematology - March 13, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar.
Conclusion: About half of Rh-Del subjects were repeated donors, and attention was needed to avoid transfusion of truly Rh-negative patients to prevent alloimmunization. It is recommended to do Rh-Del typing of Rh-negative donors who are C-antigen-positive and consider moving them to the Rh-positive pool. Further study is needed to clarify the alloimmunization status for transfusion of Rh-Del blood to Rh-negative recipients. Molecular markers for RhD-negative and D variants should be established in the Myanmar population to improve selection of antisera for Rh typing and enhance safety of the transfusion services. PMID:...
Source: Advances in Hematology - March 10, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study.
Discussion. Therefore nurse led intervention is effective in improving HRQOL among children with SCD. PMID: 32089692 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - February 26, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Haematological Profile of Adults with Malaria Parasitaemia Visiting the Volta Regional Hospital, Ghana.
This study evaluated the haematological profile of adult individuals infected with the malaria parasite. Methods: A retrospective study was conducted using archived data of malaria positive cases from January 2017 to March 15, 2019. Data retrieved included subjects' demographics, malaria parasite count, malaria parasite species, and full blood count parameters. A total of 236 malaria positive subjects were included in the study. Results: The study showed that more females were infected with the malaria parasite than males (69.07% and 30.93%, respectively). A total of 87.3% of the study population were infected with...
Source: Advances in Hematology - February 26, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Prognostic Impact of Lymphoid Enhancer Factor 1 Expression and Serum Galectin.3 in Egyptian AML Patients.
Conclusion: We conclude that high LEF1 expression was a favorable prognostic marker which can define AML patient risk and outcome independent from assessing the serum galectin.3 level. PMID: 31929803 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - January 15, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience.
Authors: Bouchla A, Thomopoulos T, Papageorgiou S, Tsirigotis P, Bazani E, Gkirkas K, Vasilatou D, Glezou E, Stavroulaki G, Gkontopoulos K, Dimitriadis G, Pappa V Abstract The coexistence of a myeloid and a lymphoid neoplasm in the same patient is a rare finding. We retrospectively searched the records of the Hematology Division of the Second Department of Internal Medicine and Research Institute at Attikon University General Hospital of Athens from 2003 to 2018. Nine cases have been identified in a total of 244 BCR-/ABL1- negative MPN and 25 MDS/MPN patients and 1062 LPD patients referred to our institution betwee...
Source: Advances in Hematology - November 30, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Study of Frequency and Characteristics of Red Blood Cell Alloimmunization in Thalassemic Patients: Multicenter Study from Palestine.
Conclusions. Anti-Rh and anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units, and history of splenectomy could not predict the occurrence of alloimmunization. PMID: 31781225 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - November 30, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence of Anemia and Associated Factors among Newly Diagnosed Patients with Solid Malignancy at Tikur Anbessa Specialized Hospital, Radiotherapy Center, Addis Ababa, Ethiopia.
Authors: Kifle E, Hussein M, Alemu J, Tigeneh W Abstract Background: Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients, worsens disease status and impairs treatment outcome; however, little is known about the prevalence of anemia and associated factors among cancer patients during diagnosis in developing countries like Ethiopia. In response to this, we have conducted research with the aim of assessing the prevalence of anemia and associated factors among newly diagnosed patients with solid malignancy at Tikur Anbessa Specialized Hospital (TASH...
Source: Advances in Hematology - November 30, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Management of Adult Patients with Primary Immune Thrombocytopenia (ITP) in Clinical Practice: A Consensus Approach of the Spanish ITP Expert Group.
Authors: Mingot-Castellano ME, Román MTÁ, Fernández Fuertes LF, González-López TJ, Guinea de Castro JM, Jarque I, López-Fernández MF, Lozano ML, Sánchez González B, Ferreiras DV, González Porras JR Abstract Background and Objective: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP. Ma...
Source: Advances in Hematology - September 21, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Corrigendum to "Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update".
Corrigendum to "Treatment of Febrile Neutropenia and Prophylaxis in Hematologic Malignancies: A Critical Review and Update". Adv Hematol. 2019;2019:4120631 Authors: Villafuerte-Gutierrez P, Villalon L, Losa JE, Henriquez-Camacho C Abstract [This corrects the article DOI: 10.1155/2014/986938.]. PMID: 31379947 [PubMed - in process] (Source: Advances in Hematology)
Source: Advances in Hematology - August 7, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Quantifying the Levels of Knowledge, Attitude, and Practice Associated with Sickle Cell Disease and Premarital Genetic Counseling in 350 Saudi Adults.
Authors: Al-Qattan HM, Amlih DF, Sirajuddin FS, Alhuzaimi DI, Alageel MS, Bin Tuwaim RM, Al Qahtani FH Abstract Our study aims to observe the levels of knowledge, attitude, and practice (KAP) associated with sickle cell disease (SCD) and premarital genetic counseling (PMGC) in 351 Saudi adults. The relationships between KAP levels and sociodemographic characteristics (age, gender, marital status, and educational level) were observed. The study was conducted in King Khalid University Hospital between February 21, 2017, and March 7, 2018. A total of 351 Saudi participants attending the primary care clinic were select...
Source: Advances in Hematology - June 13, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Lung Function Abnormalities in Sickle Cell Anaemia.
Authors: Dei-Adomakoh YA, Afriyie-Mensah JS, Forson A, Adadey M, Ndanu TA, Acquaye JK Abstract Background: Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sickle cell cohort. There is generally little information available on risk factors associated with the lung function abnormalities and its relevance in patient care. Method: This was an analytical cross-sectional study involv...
Source: Advances in Hematology - May 7, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Loxoscelism: Cutaneous and Hematologic Manifestations.
Conclusion: Treatment of systemic loxoscelism involves aggressive supportive care including appropriate wound management, blood transfusions, intravenous fluid replacement, and appropriate antibiotic coverage. It is unclear at this time if glucocorticoids or IVIg has any beneficial impact on the treatment of severe loxoscelism. PMID: 31015839 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 26, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Factors Associated with Anemia among People Living with HIV/AIDS Taking ART in Ethiopia.
Conclusions: About one in three patients was found to be anemic. Intervention aimed at diagnosing and treating anemia among people living with HIV/AIDS should be considered. PMID: 30941180 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 5, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia.
Authors: Eleutério RMN, Nascimento FO, Araújo TG, Castro MF, Filho TPA, Filho PAM, Eleutério J, Elias DBD, Lemes RPG Abstract Background: Sickle cell anaemia (SCA) is the most prevalent monogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, which modifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) synthesis. SCA treatment uses hydroxyurea (HU) to maintain h...
Source: Advances in Hematology - March 13, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Real-World Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Relapsed or Refractory Multiple Myeloma: Evidence from a Medical Record Review in France.
Conclusions: The prognostic importance of cytogenetic risk in RRMM was apparent, whereby high (versus standard) risk patients had decidedly shorter PFS and OS. Frequent hospitalizations indicated potentially high costs associated with RRMM, particularly for high risk patients. These findings may inform economic evaluations of RRMM therapies. PMID: 30838045 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - March 8, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Effect of Imatinib on Bone Marrow Morphology and Angiogenesis in Chronic Myeloid Leukemia.
This study was done to assess the effect of imatinib on bone marrow morphology and angiogenesis in CML. Methods: 31 newly diagnosed CML patients were evaluated before and after 3 months of imatinib therapy. A marrow morphological response (MMR) score was used to assess marrow cytological and histological features including grade of fibrosis. Mean microvessel density (MVD) was also assessed. Hematological parameters and BCR-ABL transcript levels were assessed in the peripheral blood. Results: 86.21% of patients showed decrease in marrow cellularity with normalization of M:E ratio. 72.42% of patients had decrease in ...
Source: Advances in Hematology - February 5, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Traceability of Blood Transfusions and Reporting of Adverse Reactions in Developing Countries: A Six-Year Postpilot Phase Experience in Burkina Faso.
Authors: Sawadogo S, Nebie K, Millogo T, Sontie S, Nana A, Dahourou H, Yonli DY, Tapko JB, Faber JC, Kafando E, Deneys V Abstract Traceability is an essential tool for haemovigilance and transfusion safety. In Burkina Faso, the implementation of haemovigilance has been achieved as part of a pilot project from 2005 to 2009. Our study aims to evaluate the traceability of blood transfusions and reporting of adverse reactions over the 6-year postpilot phase. A cross-sectional study including all blood units ordered between 2010 and 2015 has been conducted in public and private health care facilities supplied with blood...
Source: Advances in Hematology - January 25, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

Burden of Sickle Cell Disease in Ghana: The Korle-Bu Experience.
Authors: Asare EV, Wilson I, Benneh-Akwasi Kuma AA, Dei-Adomakoh Y, Sey F, Olayemi E Abstract In Africa, sickle cell disease (SCD) is a major public health problem with over 200,000 babies born per year. In Ghana, approximately 15,000 (2%) of Ghanaian newborns are diagnosed with SCD annually. A retrospective review of medical records of all SCD patients aged 13 years and above, who presented to the sickle cell clinic at Ghana Institute of Clinical Genetics (GICG), Korle-Bu, from 1st January 2013 to 31st December 2014, was carried out, using a data abstraction instrument to document their phenotypes, demographics, a...
Source: Advances in Hematology - January 12, 2019 Category: Hematology Tags: Adv Hematol Source Type: research

A Novel Approach for Objective Assessment of White Blood Cells Using Computational Vision Algorithms.
Authors: Rodríguez Barrero CM, Romero Gabalan LA, Roa Guerrero EE Abstract In the field of medicine, the analysis of blood is one of the most important exams to determine the physiological state of a patient. In the analysis of the blood sample, an important process is the counting and classification of white blood cells, which is done manually, being an exhaustive, subjective, and error-prone activity due to the physical fatigue that generates the professional because it is a method that consumes long laxes of time. The purpose of the research was to develop a system to identify and classify blood cells, by...
Source: Advances in Hematology - December 13, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

The Rising Era of Immune Checkpoint Inhibitors in Myelodysplastic Syndromes.
Authors: Chokr N, Patel R, Wattamwar K, Chokr S Abstract Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by ineffective hematopoiesis and a wide spectrum of manifestations ranging from indolent and asymptomatic cytopenias to acute myeloid leukemia (AML). MDS result from genetic and epigenetic derangements in clonal cells and their surrounding microenvironments. Studies have shown associations between MDS and other autoimmune diseases. Several immune mechanisms have been identified in MDS, suggesting that immune dysregulation might be at least partially implicated in its pathogene...
Source: Advances in Hematology - December 7, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes.
Authors: Dudina GA, Donetskova AD, Litvina MM, Mitin AN, Mitina TA, Polyakov SA Abstract We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking ...
Source: Advances in Hematology - November 10, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients.
Authors: Hamdy M, Salama N, Maher G, Elrefaee A Abstract Lower levels of vitamin D have been documented in many patients with sickle cell disease (SCD), but data are still inconclusive regarding the association between vitamin D deficiency (VDD) and the occurrence or the severity of various SCD complications. Our study aimed to detect the prevalence of vitamin D deficiency among Egyptian patients with SCD and to associate it with the clinical course of the disease. We measured the level of 25-hydroxy vitamin D in 140 children (age from 4.3 to 15.5years), 80 patients with SCD and 60 controls using enzyme-linked immu...
Source: Advances in Hematology - October 13, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence and Factors Associated with Anemia among Pregnant Women Attending Antenatal Clinic at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Conclusion: In this study the prevalence of anemia in pregnancy was low compared to the findings of others. Gestational age (trimester) and iron/folic acid supplementation were statistically associated with anemia. Therefore, iron supplementation and health education to create awareness about the importance of early booking for antenatal care are recommended to reduce anemia. PMID: 30245724 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - September 26, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests.
Conclusion: Despite statistically significant changes in RBC parameters such as MCV, RDW, and MCHC and platelet count, these changes were clinically insignificant. Hence, blood samples for CBC and coagulation assay can safely be transported via our hospital's PTS. However, further studies on platelet count are warranted to ensure safe transport and accuracy of the results. PMID: 30079089 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - August 8, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine.
Conclusions: RBC alloimmunization rate among Palestinian SCD patients is low compared to neighboring countries and countries all over the world but still warrants more attention. Phenotyping of donors/recipients' RBC for Rh antigens and K1 (partial phenotype matching) before their first transfusion may reduce the incidence of alloimmunization. PMID: 29977298 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - July 8, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Prevalence of Bleeding Symptoms among Adolescents and Young Adults in the Capital City of Saudi Arabia.
Conclusion: In this study, we report for the first time the prevalence of bleeding symptoms in a representative sample of Saudi adolescents and young adults. PMID: 29853900 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - June 2, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Association of Peripheral Monocyte Count with Soluble P-Selectin and Advanced Stages in Nasopharyngeal Carcinoma.
Conclusion: Advanced stages of nasopharyngeal carcinoma had higher levels of monocyte count and sP-selectin compared to earlier stages. Monocyte count was correlated with sP-selectin especially in high monocyte count subgroup. PMID: 29692812 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 26, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Impact of Age on Outcomes in Hospitalized Patients with Hereditary Hemorrhagic Telangiectasia.
Conclusion: Aging has significant adverse impacts on rates of hospitalization, complications, and outcomes amongst HHT patients in the United States. Except for neurologic complications, the vast majority of this disease burden is borne by patients older than 50 years. PMID: 29610574 [PubMed] (Source: Advances in Hematology)
Source: Advances in Hematology - April 5, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis.
Authors: Makis A, Gkoutsias A, Palianopoulos T, Pappa E, Papapetrou E, Tsaousi C, Hatzimichael E, Chaliasos N Abstract Immune thrombocytopenia (ITP) in children has a varied course and according to duration is distinguished as newly diagnosed (12) types. Several studies have evaluated the prognostic factors for the progression of the disease, but similar works have yet to be performed in Greece. We aimed to identify prognostic markers for the three forms of the disease in 57 Greek children during a 13-year period. Information regarding age, gender, preceding infection, bleeding type, duration of symptoms and platel...
Source: Advances in Hematology - January 26, 2018 Category: Hematology Tags: Adv Hematol Source Type: research

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy.
Authors: Farhan S, Bazydlo M, Neme K, Mikulandric N, Peres E, Janakiraman N Abstract In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu pharmacokinetics (Bu PK) and those who received busulfan with cyclophosphamide (BuCy). Fifty-five patients received FluBu4, of whom 21 had Bu PK measured, and 23 patients received BuCy. Total donor cell chimerism showed that the percentage of patients maintaining 100% donor chimerism on ...
Source: Advances in Hematology - December 20, 2017 Category: Hematology Tags: Adv Hematol Source Type: research