The effect of high-intensity laser therapy on pain and lower extremity function in patellofemoral pain syndrome: a single-blind randomized controlled trial
This study indicated that high-intensity laser therapy was found to be a more effective method in the treatment of patellofemoral pain syndrome after 3 months of follow-up compared to US-TENS combination and US-interferential current combination treatments. Also, HILT can be used as an effective method in combination with an appropriate exercise program including vastus medialis strengthening to reduce pain and increase functionality in the patients with PFPS. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - April 17, 2024 Category: Laser Surgery Source Type: research
Inborn Errors of Immunity in Jordan: First Report from a Tertiary Referral Center
ConclusionsThe high minimal estimated IEI prevalence at 16.2/100,000 Jordanian children compared to the regional and worldwide data, with the diversities in clinical presentation and distribution of IEI categories in our cohort point to unique features of IEI in Jordanian children, call for national registry establishment, regional and international collaborative networks. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 17, 2024 Category: Allergy & Immunology Source Type: research
Effectiveness of secondary furlow palatoplasty with buccal myomucosal flap in correction of velopharyngeal insufficiency in patients with cleft palate
ConclusionsThe incorporation of a buccal myomucosal flap with Furlow palatoplasty was successful in improving hypernasality, speech intelligibility, and nasopharyngoscopic scores in patients with cleft palate.Trial registrationclinicaltrials.gov (NCT05626933).Clinical relevanceThis technique might be the surgical technique of choice while treating patients who are suffering from VPI after cleft palate repair. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 17, 2024 Category: Dentistry Source Type: research
Endoscopic closure techniques of bariatric surgery complications: a meta-analysis
ConclusionObservational reports show that patients managed with OTSC were more likely to experience healing of their defect than those managed with endoscopic suturing. Larger controlled studies comparing different closure devices for bariatric leaks should be carried out to better understand the ideal endoscopic approach to these complications. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 17, 2024 Category: Surgery Source Type: research
Management of symptomatic, asymptomatic, and recurrent hiatal hernia: a systematic review and meta-analysis
ConclusionsThe evidence for optimal management of symptomatic and recurrent hiatal hernia remains controversial, underpinned by studies with a high risk of bias. Shared decision making between surgeon and patient is essential for optimal outcomes. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 17, 2024 Category: Surgery Source Type: research
Association of the rate of torque development and joint angle with passive muscle stiffness
ConclusionsA greater relative RTD occurs at plantarflexed angles (i.e., the ascending limb of the force –length curve) in the triceps surae, and relative RTD is strongly related to passive MG stiffness at dorsiflexed angles (i.e., longer muscle lengths). (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 17, 2024 Category: Physiology Source Type: research
Perinatal mortality in German dairy cattle: Unveiling the importance of cow-level risk factors and their interactions using a multifaceted modelling approach
This article aims to investigate the factors contributin g to PM in two underexplored breeds, Simmental (SIM) and Brown Swiss (BS), while comparing them to German Holstein on German farms, and to employ various modelling techniques to enhance comparability to other studies, and to determine if different statistical methods yield consistent results. A tota l of 133,942 calving records from 131,657 cows on 721 German farms were analyzed. Amongst these, the proportion of PM (defined as stillbirth or death up to 48 hours of age) was 6.1%. Univariable and multivariable mixed-effects logistic regressions, random forest and multi...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Yury Zablotski Source Type: research
Both religious and secular ethics to achieve both happiness and health: Panel data results based on a dynamic theoretical model
by Fabio Zagonari
This paper evaluates the direct and indirect impacts (and their interactions) of individual and social ethics from (primary, secondary, tertiary) education and religion (Buddhism, Christianity, Hinduism, Islam, Judaism) on health and happiness in alternative religious contexts (majority and minori ty religions) and for alternative education policies (gross enrolment and per-student expenditure). It also specifies the time lag for the short-run indirect impact (and its size) of happiness on health and the long-run equilibria of both happiness and health. The statistical results show that there is no relig...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Fabio Zagonari Source Type: research
Sensors, Vol. 24, Pages 2572: Error Model for the Assimilation of All-Sky FY-4A/AGRI Infrared Radiance Observations
In this study, we introduce two cloud-affected (Ca) indices to quantify the impact of cloud amount and establish dynamic observation error models to address biases between O−B and Gaussian distributions when assimilating all-sky data from FY-4A/AGRI observations. For each Ca index, we evaluate two dynamic observation error models: a two-segment and a three-segment linear model. Our findings indicate that the three-segment linear model we propose better conforms to the statistical characteristics of FY-4A/AGRI observations and improves the Gaussianity of the O−B probability density function. Dyna...
Source: Sensors - April 17, 2024 Category: Biotechnology Authors: Dongchuan Pu Yali Wu Tags: Article Source Type: research
Linking the protease activity to the nematicidal action of edible mushroom
AbstractBiological control using edible mushrooms as natural enemies is a sustainable alternative for pest management. Despite the well-established literature on toxins and secondary metabolites produced by these fungi in the biochemical control of nematodes, the nematicidal activity of proteases from differentPleurotus species is yet to be investigated. Therefore, this study aimed to correlate protease to the nematicidal activity of different mushrooms,Pleurotus sp.,P. ostreatus (SB),P. ostreatus (Pearl), andP. djamor. For such a purpose, we performed motility assays ofPanagrellus sp. at different time intervals, 6, 12, a...
Source: World Journal of Microbiology and Biotechnology - April 17, 2024 Category: Microbiology Source Type: research
Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol
Introduction
Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by alcohol exposure during pregnancy. FASD is associated with neurodevelopmental deviations, and 50%–94% of children with FASD meet the Diagnostic and Statistical Manual of Mental Disorders-fifth edition diagnostic criteria for attention deficit hyperactivity disorder (ADHD). There is a paucity of evidence around medication efficacy for ADHD symptoms in children with FASD. This series of N-of-1 trials aims to provide pilot data on the feasibility of conducting N-of-1 trials in children with FASD and ADHD.
Methods and analysis...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Crichton, A., Harris, K., McGree, J. M., Nikles, J., Anderson, P. J., Williams, K. Tags: Open access, Paediatrics Source Type: research
Short post-injection seizure duration is associated with reduced power of ictal brain perfusion SPECT to lateralize the seizure onset zone
ConclusionsShort post-injection seizure duration is associated with a lower proportion of lateralizing cases in ictal brain perfusion SPECT. (Source: EJNMMI Research)
Source: EJNMMI Research - April 17, 2024 Category: Radiology Source Type: research
Bayesian approach to assessing population differences in genetic risk of disease with application to prostate cancer
by Iain R. Timmins, The PRACTICAL Consortium , Frank Dudbridge
Population differences in risk of disease are common, but the potential genetic basis for these differences is not well understood. A standard approach is to compare genetic risk across populations by testing for mean differences in polygenic scores, but existing studies that use this approach do not account for statistical noise in effect estimates (i.e., the GWAS betas) that arise due to the finite sample size of GWAS training data. Here, we show using Bayesian polygenic score methods that the level of uncertainty in estimates of genetic risk differences acr...
Source: PLoS Genetics - April 17, 2024 Category: Genetics & Stem Cells Authors: Iain R. Timmins Source Type: research
CoVar: A generalizable machine learning approach to identify the coordinated regulators driving variational gene expression
We present CoVar, an ML-based framework that builds upon the properties of existing inference models, to find the central genes driving perturbed gene expression across biological states. Unlike differentially expressed genes (DEGs) that capture changes in individual gene expression across conditions, CoVar focuses on identifyingvariational genes that undergo changes in their expression network interaction profiles, providing insights into changes in the regulatory dynamics, such as in disease pathogenesis. Subsequently, it findscore genes from among the nearest neighbors of these variational genes, which are central to th...
Source: PLoS Computational Biology - April 17, 2024 Category: Biology Authors: Satyaki Roy Source Type: research
Is 3T MR nerve-bone fusion imaging a viable alternative to MRI-CBCT to identify the relationship between the inferior alveolar nerve and mandibular third molar
ConclusionsBoth MR nerve-bone fusion and MRI-CBCT fusion exhibited good consistency in evaluating the spatial relationship between IAN/MC and MTM, fusion effect, and inflammation detection.Clinical relevanceMR nerve-bone fusion imaging can be a preoperative one-stop radiation-free examination for patients at high risk for MTM surgery. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 17, 2024 Category: Dentistry Source Type: research
