Short-Term Classification Learning Promotes Rapid Global Improvements of Information Processing in Human Brain Functional Connectome
Classification learning is a preeminent human ability within the animal kingdom but the key mechanisms of brain networks regulating learning remain mostly elusive. Recent neuroimaging advancements have depicted human brain as a complex graph machinery where brain regions are nodes and coherent activities among them represent the functional connections. While long-term motor memories have been found to alter functional connectivity in the resting human brain, a graph topological investigation of the short-time effects of learning are still not widely investigated. For instance, classification learning is known to orchestrat...
Source: Frontiers in Human Neuroscience - January 14, 2020 Category: Neuroscience Source Type: research

Cross-Situational Statistical Learning of New Words Despite Bilateral Hippocampal Damage and Severe Amnesia
Word learning requires learners to bind together arbitrarily-related phonological, visual, and conceptual information. Prior work suggests that this binding can be robustly achieved via incidental cross-situational statistical exposure to words and referents. When cross-situational statistical learning (CSSL) is tested in the laboratory, there is no information on any given trial to identify the referent of a novel word. However, by tracking which objects co-occur with each word across trials, learners may acquire mappings through statistical association. While CSSL behavior is well-characterized, its brain correlates are ...
Source: Frontiers in Human Neuroscience - January 14, 2020 Category: Neuroscience Source Type: research

Low-dose CT angiography using ASiR-V for potential living renal donors: a prospective analysis of image quality and diagnostic accuracy
ConclusionLow-dose CT angiography using ASiR-V is useful to evaluate renal vasculature for potential living renal donors.Key Points• In this prospective study, adaptive statistical iterative reconstruction V (ASiR-V) allowed 58.2% dose reduction while maintaining diagnostic image quality for renal vessels.• As compared with the standard protocol, the dose with ASiR-V was significantly lower (9.5 ± 0.8 mGy) than with standard computed tomography (CT) angiography (22.7 ± 4.1 mGy).• Low-dose CT using ASiR-V is useful for living donor evaluation before nephrect...
Source: European Radiology - January 13, 2020 Category: Radiology Source Type: research

Translation and cultural adaptation of the mediterranean diet quality index in children and adolescents
Conclusions: The KIDMED questionnaire was translated into Brazilian Portuguese and culturally adapted, pr esenting high reproducibility. This questionnaire can, therefore, be included and used in Brazilian studies that aim at evaluating the adherence to the Mediterranean diet among children and adolescents.RESUMO Objetivo: Traduzir e adaptar culturalmente a escala do Mediterranean Diet Quality Index in Children and Adolescent (KIDMED) para a popula ção brasileira. Métodos: Os processos de tradução e adaptação cultural seguiram normas metodológicas padronizadas interna...
Source: Revista Paulista de Pediatria - January 13, 2020 Category: Pediatrics Source Type: research

The impact of small intestinal bacterial overgrowth on the growth of children and adolescents
Conclusions: Children and adolescents with SBIO associated with diseases of the gastrointestinal tract have lower weight and height values.RESUMO Objetivo: Avaliar a exist ência de associação entre sobrecrescimento bacteriano no intestino delgado (SBID) e comprometimento de peso e estatura em crianças e adolescentes com doenças do aparelho digestivo. Métodos: Estudo observacional e retrospectivo em ambulatório de gastroenterologia pediátrica. Foram incluídos todos os 162 pacientes com idade inferior a 19 anos que realizaram teste respiratório para pesquis...
Source: Revista Paulista de Pediatria - January 13, 2020 Category: Pediatrics Source Type: research

Quality of life evaluation and associated factorsin asthmatic children and adolescents attended in a specialized outpatient clinic
ABSTRACT Objective: To evaluate the quality of life and its association with disease control, severity, allergic comorbidities and adherence to treatment in children and adolescents with asthma. Methods: A cross-sectional study that included children and adolescents aged seven to 17. The Paediatric Asthma Quality of Life Questionnaire (PAQLQ) was used to assess their quality of life. Sociodemographic and clinical data were obtained from the chart and from a questionnaire. Descriptive statistics were performed and chi-square or Fisher ’ s exact tests were used to verify the existence of associations between quality of...
Source: Revista Paulista de Pediatria - January 13, 2020 Category: Pediatrics Source Type: research

How can new technologies help reduce absenteeism in pediatric consultation?
Conclusions: Using new tools, such as WhatsApp, to remind guardians of appointments reduces absenteeism. Consequently, it may lead to a reduction in abandoning treatment and it may improvetreatment outcome of children with a tuberculosis infection or disease.RESUMO Objetivo: Identificar a forma mais efetiva de contato, como possibilidade de interven ção, para diminuir o absenteísmo em consultas de crianças com suspeita ou com tuberculose pulmonar. Métodos: Ensaio clínico randomizado com coleta de dados prospectiva, entre março de 2017 e fevereiro de 2018. Os pacientes foram ...
Source: Revista Paulista de Pediatria - January 13, 2020 Category: Pediatrics Source Type: research

Baby-led weaning, an overview of the new approach to food introduction: integrative literature review
Conclusions: Despite the benefits found, the risks still deserve attention and should be investigated with longitudinal randomized controlled studies to ensure the safety of the method when practiced exclusively.RESUMO Objetivo: Analisar a literatura cient ífica referente ao desmame guiado pelo bebê (Baby-Led Weaning) por meio de revisão integrativa de literatura a fim de identificar riscos e benefícios. Fonte de dados: As bases de dados utilizadas foram: National Library of Medicine (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), US National Library...
Source: Revista Paulista de Pediatria - January 13, 2020 Category: Pediatrics Source Type: research

Is TKA with computer-assisted navigation associated with less blood loss? A comparative study between computer-navigated and conventional method.
Publication date: Available online 13 January 2020Source: Journal of OrthopaedicsAuthor(s): Diamantis Mitsiou, Emilios E. Pakos, Dimitrios V. Papadopoulos, Giorgos Georgiadis, Ioannis D. Gelalis, Andreas G. Tsantes, Ioannis Gkiatas, Nikos Kalos, Theodoros A. XenakisAbstractThe aim of this study is to evaluate whether computer-assisted navigated TKA reduces perioperative blood loss. Patients were randomly divided into 2 groups and underwent either a conventional TKA (n=40) or a TKA with computer-assisted navigation (n=40). Perioperative blood loss was evaluated by laboratory parameters, postoperative drain output and number...
Source: Journal of Orthopaedics - January 13, 2020 Category: Orthopaedics Source Type: research

Mineral Composition of Connarus (Connarus perrottetii var. angustifolius) and Mansoa (Mansoa alliacea) Species
Conclusion: Connarus perrottetii var. angustifolius and Mansoa alliacea showed low concentrations of metals that may be toxic above specific concentrations (Cr, Ni, As, Pb, Cd and Hg). Accordingly, a regular consumption of these species cannot cause intoxication. On the other hand, we should consider the mineral contribution of other foods on the daily diet. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - January 13, 2020 Category: Nutrition Source Type: research

Folic Acid and Vitamin B12 Supplementation on Male Patients with Schizophrenia Predominant Negative Symptoms
This study is a quasi experimental pre-test and post-test designs that are divided into two groups, they are group receiving risperidone with the addition of folic acid and vitamin B12 and the group receiving only risperidone. Diagnosis of schizophrenia according to the International Classification of Diseases (ICD-10) criteria and negative symptoms assessed by using negative subscale of PANSS Scores are observed. Statistical analysis is conducted using Statistical Package for the Social Sciences (SPSS) software. Results: There was a significant difference in the mean score of negative-scale PANSS scores at the end of week...
Source: Current Nutrition and Food Science - January 13, 2020 Category: Nutrition Source Type: research

The role of diabetes mellitus on the thrombus composition in patients with acute ischemic stroke.
CONCLUSION: Clots in diabetic patients had more fibrin and fewer erythrocyte components compared with patients without diabetes mellitus, while hyperglycemia on admission did not show association with clot composition. Further studies are needed to confirm these results. PMID: 31924102 [PubMed - as supplied by publisher] (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - January 13, 2020 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Emission Stations Location Selection Based on Conditional Measurement GAN Data
Publication date: Available online 13 January 2020Source: NeurocomputingAuthor(s): Zhenyi Xu, Yu Kang, Yang CaoAbstractUrban vehicle emission monitoring can help make suggestions for the pollution emission control, and can protect public health. However, it is hard to get an overview of the vehicle emission in the city scale due to the sparse emission remote sensing stations in city, and selecting the appropriate stations locations which can reflect the emission variation in the given region mostly is another challenge. The existing methods solve the problem by spatial interpolation based on geographical statistics methods...
Source: Neurocomputing - January 13, 2020 Category: Neuroscience Source Type: research

The effect of Lean Six Sigma practices on food industry performance: Implications of the Sector's experience and typical characteristics
Publication date: Available online 13 January 2020Source: Food ControlAuthor(s): Luana Bonome Message Costa, Moacir Godinho Filho, Lawrence D. Fredendall, Gilberto Miller Devós GangaAbstractLean, Six Sigma and Lean Six Sigma initiatives (L&SSi) have been adopted by different industry and service sectors to improve companies' performance and competitiveness; however, adoption in the food industry is still very low. The sector lacks familiarity with the L&SSi initiatives; it views “quality” as a safety and hygiene factor, which is one characteristic that differentiates it from other sectors. The pu...
Source: Food Control - January 13, 2020 Category: Food Science Source Type: research

Perineal outcomes and its associated variables of water births versus non-water births: a cross-sectional study
Conclusions: the results of the study suggest that childbirth in water has a protective effect against severe third or fourth degree perineal tears , during fetal expulsion in water.Resumo Objetivos: descrever os resultados perineais de mulheres que tiveram parto na água e fora da água. Métodos: estudo transversal e quantitativo desenvolvido em um hospital público de Setúbal, Portugal. A população foi de mulheres que participaram do "Projeto Parto na Água", no período de 2011 a 2014, que deram à luz na água e fora da água. Foram s...
Source: Revista Brasileira de Saude Materno Infantil - January 13, 2020 Category: Midwifery Source Type: research

Low birth weight in a subnormal urban cluster under Family Health Strategy’s care
Abstract Objectives: to identify the prevalence and to analyze the factors associated with low birth weight in a subnormal urban cluster in Pernambuco under Family Health Strategy ’ s care. Methods: a cross-sectional study with a census sample carried out between July and October in 2015. The variables studied were age and years of maternal schooling, social status, housing, water supply, waste disposal, prenatal care, alcohol consumption and cigarette smoking during pregnancy, along with gender, birth weight and prematurity. Stata 12.1 was utilized in order to understand the factors associated with low birth weight ...
Source: Revista Brasileira de Saude Materno Infantil - January 13, 2020 Category: Midwifery Source Type: research

Prenatal and puerperal care and indicators of severity: a study about the information available on pregnant women’s card
Conclusions: it was possible to conclude that the more adequate prenatal care, the lower the chances of unfavorable outcomes and incidence of risks.Resumo Objetivos: identificar e discutir a frequ ência da assistência pré-natal e puerperal de gestantes da zona leste de São Paulo - SP, categorizando-a de acordo com o Índice de Kessner modificado em 1993 por Takeda, com base nos dados disponíveis no cartão da gestante e no resumo de alta, correlacionando os resultados com os indicadores de gravidade no parto. Métodos: trata-se de um estudo descritivo, transversal de car&a...
Source: Revista Brasileira de Saude Materno Infantil - January 13, 2020 Category: Midwifery Source Type: research

Risk of being granted disability pension among incident cancer patients before and after a structural pension reform: A Danish population-based, matched cohort study
Conclusion The 2013 reform of the Disability Pensio n Act reduced the risk of cancer patients being granted DP. The impact on a personal level should be further explored.byPedersen P, Aagesen M, Tang LH, Bruun NH, Zwisler A-D, Stapelfeldt CM. doi:10.5271/sjweh.3879 (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - January 13, 2020 Category: Occupational Health Tags: Original article Source Type: research

Study of precipitation and growth processes of Ti-bearing inclusions in tire cord steel
Publication date: Available online 13 January 2020Source: Results in PhysicsAuthor(s): Ning Li, Lu Wang, Zheng-Liang Xue, Cheng-Zhi Li, Ao Huang, Fang-Fang WangAbstractPrecipitation behavior and growth kinetics of Ti-bearing inclusions in SWRH 92A tire cord steel were analyzed in the present work. The calculated results showed that higher cooling rate would lead to a higher precipitation ratio of solution elements and make the precipitation time of inclusions earlier. However, both TiCyN1-y (a continuous solid solution between TiC and TiN, y denotes the molar ratio of TiC in TiCyN1-y) and TiN could only precipitate in the ...
Source: Results in Physics - January 13, 2020 Category: Physics Source Type: research

GSE111434 Genome wide gene expression analysis of acutely injured primary mouse neurons
Contributors : Alex Schulz ; Marco GrothSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe aimed at identifying a common transcriptional response of neurons to acute injury by conducting a RNA-Seq analysis on primary mouse neurons. We performed parallel damaging of cultured neurons by applying oxygen-glucose deprivation (OGD) as model for cerebral ischemia as well as excitotoxicity induced by the glutamate receptor agonist kainic acid (KA) as an in vitro model amyotrophic lateral sclerosis and epilepsy. For each of the assays, we determined the experimental conditions in which 20% of ...
Source: GEO: Gene Expression Omnibus - January 13, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

A three-level Multiple-Kernel Learning approach for soil spectral analysis
Publication date: Available online 11 January 2020Source: NeurocomputingAuthor(s): Nikolaos L. Tsakiridis, Christos G. Chadoulos, John B. Theocharis, Eyal Ben-Dor, George C. ZalidisAbstractTo ensure the sustainability of the soil ecosystem, which is the basis for food production, efficient large-scale baseline predictions and trend assessments of key soil properties are necessary. In that regard, visible, near-infrared, and shortwave infrared (VNIR–SWIR) spectroscopy can provide an alternative for the expensive wet chemistry. In this paper, we examined the application of the Multiple-Kernel Learning (MKL) approach to...
Source: Neurocomputing - January 13, 2020 Category: Neuroscience Source Type: research

Pernicious azotaemia? A case series of subacute combined degeneration of the cord secondary to nitrous oxide abuse
We report four cases of females aged 18–24 years presenting with clinical symptoms of subacute combined degeneration of the spinal cord. MRI during admission demonstrated the classic findings of T2 hyperintensity, predominantly within the dorsal columns of the spinal cord, with variable involvement of the lateral corticospinal tracts. These cases highlight the ready availability of nitrous oxide and the fact that heavy prolonged recreational use is occurring in the community. It is important that clinicians in emergency and community settings are alerted to this unusual cause of subacute combined degeneration of...
Source: Journal of Clinical Neuroscience - January 13, 2020 Category: Neuroscience Source Type: research

Reference-mean-centered statistical quality control
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - January 13, 2020 Category: Laboratory Medicine Source Type: research

Correction to: An individualised versus a conventional pneumoperitoneum pressure strategy during colorectal laparoscopic surgery: rationale and study protocol for a multicentre randomised clinical study
After publication of our article [1] the authors have notified us that there are changes in the primary outcome and the statistical analysis plan of the study. (Source: Trials)
Source: Trials - January 13, 2020 Category: General Medicine Authors: O. Diaz-Cambronero, G. Mazzinari, C. L. Errando, M. J. Schultz, B. Flor Lorente, N. Garc ía-Gregorio, M. Vila Montañés, Daniel Robles-Hernández, L. E. Olmedilla Arnal, A. Martín-De-Pablos, A. Marqués Marí and M. P. Argente Navarro Tags: Correction Source Type: research

Emission inventories of rice straw open burning in the Red River Delta of Vietnam: Evaluation of the potential of satellite data.
Abstract Although rice straw open burning is one of the main sources of air pollution in Asian countries, problems remain in collecting the activity data needed to calculate emission inventories. In Vietnam, the results from traditional data collection methods, which are reported by the Vietnam General Statistics Office high levels of uncertainty. This is largely due to a lack of human and financial resources. To improve upon this, this study critically assessed the benefits of incorporating cultivation area data obtained by the Sentinel-1 Synthetic Aperture Radar (SAR) satellite in combination with crop productio...
Source: Environmental Pollution - January 13, 2020 Category: Environmental Health Authors: Le HA, Phuong DM, Linh LT Tags: Environ Pollut Source Type: research

Feature selection for OPLS discriminant analysis of cancer tissue lipidomics data
AbstractThe mass spectrometry ‐based molecular profiling can be used for better differentiation between normal and cancer tissues and for the detection of neoplastic transformation, which is of great importance for diagnostics of a pathology, prognosis of its evolution trend, and development of a treatment strategy. The aim of the present study is the evaluation of tissue classification approaches based on various data sets derived from the molecular profile of the organic solvent extracts of a tissue. A set of possibilities are considered for the orthogonal projections to latent structures discriminant analysis: all mas...
Source: Journal of Mass Spectrometry - January 13, 2020 Category: Chemistry Authors: Alisa O. Tokareva, Vitaliy V. Chagovets, Natalia L. Starodubtseva, Niso M. Nazarova, Maria E. Nekrasova, Alexey S. Kononikhin, Vladimir E. Frankevich, Evgeny N. Nikolaev, Gennady T. Sukhikh Tags: APPLICATION NOTE Source Type: research

Statistical analysis of the crystallinity index of nanocellulose produced from Kraft pulp via controlled enzymatic hydrolysis
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - January 13, 2020 Category: Biochemistry Authors: Ruan Stevan Almeida Ribeiro, Ninoska Bojorge, Nei Pereira Junior Tags: Original Article Source Type: research

Visualization of endometriosis with laparoscopy and near ‐infrared optics with indocyanine green
ConclusionsThe diagnostic value of NIR ‐ICG imaging in identifying endometriosis appears to be minimal. ICG exposure time over 20 minutes, no previous abdominal surgery, and low rASRM stages have a significant positive effect on the ICG detection rate. NIR fluorescence imaging with ICG was helpful in the resection of deep infiltrating nodules by providing a better visualization of endometriosis. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 13, 2020 Category: OBGYN Authors: Franziska Siegenthaler, Laura Knabben, Stefan Mohr, Konstantinos Nirgianakis, Sara Imboden, Michael D. Mueller Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Sixto Obrador SENEC prize 2019: Utility of diffusion tensor imaging as a prognostic tool in moderate to severe traumatic brain injury. Part I. Analysis of DTI metrics performed during the early subacute stage.
CONCLUSIONS: We conclude that DTI is a useful tool to characterize TAI and the detection of FA reduction in the subacute stage after TBI is associated with long-term unfavorable outcome. PMID: 31948842 [PubMed - as supplied by publisher] (Source: Neurocirugia)
Source: Neurocirugia - January 13, 2020 Category: Neurosurgery Authors: Castaño-Leon AM, Cicuendez M, Navarro-Main B, Munarriz PM, Paredes I, Cepeda S, Hilario A, Ramos A, Gómez PA, Lagares A Tags: Neurocirugia (Astur) Source Type: research

Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.
In conclusion, ROS in the SGNs were activated by increased S100B expression in ApoE KO-WD male mice, and this resulted in an increased apoptosis rate. Thus, hearing loss began at 16 weeks in ApoE KO-WD male mice. Our results suggest that the ApoE KO-WD male mice are a suitable animal model for studying ARHL associated with exacerbated atherosclerosis. PMID: 31948760 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - January 13, 2020 Category: Biochemistry Authors: Kim YY, Chao JR, Kim C, Kim B, Thi-Thanh Nguyen P, Jung H, Chang J, Lee JH, Suh JG Tags: Biochem Biophys Res Commun Source Type: research

Outcomes of surgery in eyes with familial exudative vitreoretinopathyassociated retinal detachment.
CONCLUSIONS: Favourable outcomes can be achieved, though multiple surgical interventions may, however, be necessary for the ultimate success in some cases. PMID: 31941588 [PubMed - as supplied by publisher] (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - January 13, 2020 Category: Opthalmology Authors: Sen P, Singh N, Rishi E, Bhende P, Rao C, Rishi P, Bhende M, Sharma T, Gopal L Tags: Can J Ophthalmol Source Type: research

MicroRNAs expressed in neuronal differentiation and their associated pathways: systematic review and bioinformatics analysis.
In this study a panel of altered miRNAs in neuronal differentiation was created with their related pathways, which could be a step towards understanding the complex network of miRNAs in neuronal differentiation. PMID: 31945407 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - January 13, 2020 Category: Neurology Authors: Giorgi Silveira R, Perelló Ferrúa C, do Amaral CC, Fernandez Garcia T, de Souza KB, Nedel F Tags: Brain Res Bull Source Type: research

Null hypothesis significance testing and effect sizes: can we 'effect' everything … or … anything?
Null hypothesis significance testing and effect sizes: can we 'effect' everything … or … anything? Curr Opin Pharmacol. 2020 Jan 13;: Authors: Lovell DP Abstract The Null Hypothesis Significance Testing (NHST) paradigm is increasingly criticized. Estimation approaches such as point estimates and confidence intervals, while having limitations, provide better descriptions of results than P-values and statements about significance levels. Their use is supported by many statisticians. The effect size approach is an important part of power and sample size calculations at the experimental desi...
Source: Current Opinion in Pharmacology - January 13, 2020 Category: Drugs & Pharmacology Authors: Lovell DP Tags: Curr Opin Pharmacol Source Type: research

Predictive Impact of Mucinous Tumors on the Clinical Outcome in Patients with Poorly Differentiated, Stage II Colon Cancer: A TOSCA Subgroup Analysis.
CONCLUSION: Patients with MUC, grade 3, stage II CC require special attention and may need 6 months of oxaliplatin-based chemotherapy. Larger studies are required to assess the combined use of histology and other prognostic/predictive factors to define the administration of chemotherapy in patients with stage II CC and to improve their prognosis. IMPLICATIONS FOR PRACTICE: Although ASCO and ESMO guidelines define the prognostic factors for patients with stage II colon cancer to establish the use of adjuvant chemotherapy, the influence of histological subtypes is controversial in this population. This study underscores...
Source: The Oncologist - January 13, 2020 Category: Cancer & Oncology Authors: Rosati G, Galli F, Cantore M, Bergamo F, Banzi M, Zampino MG, Mattioli R, Cardellino GG, Ronzoni M, Di Bartolomeo M, Tamberi S, Marchetti P, Rimassa L, Corsi D, Bochicchio AM, Artioli F, Labianca R, Galli F, Rulli E, Bilancia D, Bregni G, TOSCA (Three or Tags: Oncologist Source Type: research

Ocular toxoplasmosis associated with up-regulation of miR-155-5p/miR-29c-3p and down-regulation of miR-21-5p/miR-125b-5p.
This study evaluated gene expression of miR-155-5p, miR-146a-5p, miR-21-5p, miR-29c-3p and miR-125b-5p in plasma of 51 patients with ocular toxoplasmosis (OT Group), 26 individuals with asymptomatic toxoplasmosis (AT Group), and 25 healthy individuals seronegative for toxoplasmosis (NC Group). Peripherical blood samples were collected in tube with EDTA for plasma isolation, laboratorial diagnosis for toxoplasmosis and RNA extraction. miRNA expression of each sample was performed by qPCR and values were expressed in Relative Quantification (RQ). Results showed that miR-155-5p and miR-29c-3p were up-expressed in OT patients ...
Source: Cytokine - January 13, 2020 Category: Molecular Biology Authors: Meira-Strejevitch CS, Pereira IS, Hippólito DDC, Maia MM, Cruz AB, Gava R, Brandão de Mattos CC, Frederico FB, Siqueira RC, Mattos LC, Pereira-Chioccola VL Tags: Cytokine Source Type: research

Modelling monotonic effects of ordinal predictors in Bayesian regression models.
r E Abstract Ordinal predictors are commonly used in regression models. They are often incorrectly treated as either nominal or metric, thus under- or overestimating the information contained. Such practices may lead to worse inference and predictions compared to methods which are specifically designed for this purpose. We propose a new method for modelling ordinal predictors that applies in situations in which it is reasonable to assume their effects to be monotonic. The parameterization of such monotonic effects is realized in terms of a scale parameter b representing the direction and size of the effect and a s...
Source: The British Journal of Mathematical and Statistical Psychology - January 13, 2020 Category: Statistics Authors: Bürkner PC, Charpentier E Tags: Br J Math Stat Psychol Source Type: research

Statistical tools for seed bank detection.
We present tractable formulas for Wright's FST and the expected site frequency spectrum for these models, and show that they can distinguish between some models for certain ranges of parameters. We then use pseudo-marginal MCMC to show that the full likelihood can reliably distinguish between all models in the presence of parameter uncertainty under moderate stratification, and point out statistical pitfalls arising from stratification that is either too strong or too weak. We further show that it is possible to infer parameters, and in particular determine whether mutation is taking place in the (strong) seed bank. P...
Source: Theoretical Population Biology - January 13, 2020 Category: Biology Authors: Blath J, Buzzoni E, Koskela J, Berenguer MW Tags: Theor Popul Biol Source Type: research

A single-injection targeted metabolomics profiling method for determination of biomarkers to reflect tripterygium glycosides efficacy and toxicity.
In this study, we proposed a single-injection targeted metabolomics method to identify reliable tripterygium glycosides efficacy and toxicity related biomarkers based on ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Through careful optimization of the UHPLC-MS/MS conditions, a total of 289 metabolites can be quantified in single-injection of 27 min using both positive and negative scanning modes with rapid polarity switching. Tripterygium glycosides is widely used in clinical for its excellent anti-inflammatory and immunosuppressive functions. However, it is the most common drug tha...
Source: Toxicology and Applied Pharmacology - January 13, 2020 Category: Toxicology Authors: Hu T, Shi C, Liu L, Li P, Sun Y, An Z Tags: Toxicol Appl Pharmacol Source Type: research

Investigating the environmental Kuznets curve for Annex I countries using heterogeneous panel data analysis.
Abstract Our paper examines the environmental Kuznets curve (EKC) relationship through a heterogeneous panel analysis of 34 Annex I countries for the 1990 to 2016 period. We confirm the long-run equilibrium relationship between carbon emissions, trade openness, fossil fuel usage, and GDP through the panel cointegration tests that is robust to cross-sectional dependence. Overall, our finding is that the empirical results show no consistent evidence of the EKC hypothesis in Annex I countries via mean group and long-run estimation. Country-specific estimation shows that only 5 of the 34 countries support the EKC hypo...
Source: Environmental Science and Pollution Research International - January 13, 2020 Category: Environmental Health Authors: Jin T, Kim J Tags: Environ Sci Pollut Res Int Source Type: research

Sugar-alcohol industry: quality of its biotreated washing water for reuse in fertigation.
z AMQ Abstract All processes in agro-industries consume water and generate large volumes of nutrient-rich effluents. To recycle effluents from a sugar-alcohol industry in the Northeastern Brazil (Coruripe, Alagoas), the effect of a daily application of a microbial formulation (containing five indigenous bacteria and two fungi), at the entrance of the two first facultative ponds (D, E) of its treatment plant formed by seven ponds (A-G), was evaluated in the sugarcane harvests of 2014/2015 and 2015/2016. Fortnightly, the values of 11 physicochemical parameters were checked and statistically compared (one and two-way...
Source: Environmental Science and Pollution Research International - January 13, 2020 Category: Environmental Health Authors: Dos Santos Silva AL, Dos Santos ECL, López AMQ Tags: Environ Sci Pollut Res Int Source Type: research

Transcriptional and biochemical biomarker responses in a freshwater mussel (Anodonta anatina) under environmentally relevant Cu exposure.
d O Abstract Molecular biomarkers, like gene transcripts or enzyme activities, are potentially powerful tools for early warning assessment of pollution. However, a thorough understanding of response and baseline variation is required to distinguish actual effects from pollution. Here, we assess the freshwater mussel Anodonta anatina as a biomarker model species for freshwater ecosystems, by testing responses of six transcriptional (cat, gst, hsp70, hsp90, mt, and sod) and two biochemical (AChE and GST) biomarkers to environmentally relevant Cu water concentrations. Mussels (n = 20), collected from a st...
Source: Environmental Science and Pollution Research International - January 13, 2020 Category: Environmental Health Authors: Ekelund Ugge GMO, Jonsson A, Olsson B, Sjöback R, Berglund O Tags: Environ Sci Pollut Res Int Source Type: research

Voice in Digital Education: The Impact of Instructor's Perceived Age and Gender on Student Learning and Evaluation
In this study, undergraduate and graduate students were randomly exposed to one of five digital tutorials; four experimental tutorials presenting identical anatomy content with narrators of different gender and age, and a control tutori al featuring origami (paper folding) instructions without audio. Learning outcomes were measured by pre‐quiz vs. post‐quiz comparisons using repeated measures MANOVA. Implicit bias was analyzed by evaluation response comparisons using repeated measures MANOVA and three‐way MANOVA. Post‐quiz scores increased significantly in the four experimental groups (P   0.26), suggesti...
Source: Anatomical Sciences Education - January 13, 2020 Category: Anatomy Authors: Laura J. Weinkle, Jennifer M. Stratford, Lisa M. J. Lee Tags: Research Report Source Type: research

Optimized cutoff maternal age for adverse obstetrical outcomes: a multicenter retrospective cohort study in Urban China during 2011 to 2012.
This study aimed to identify the clinically cutoff maternal age for adverse obstetric outcomes in China. METHODS: This secondary analysis of a multicenter retrospective cohort study included data of childbearing women from 39 hospitals collected in urban China during 2011 to 2012. Logistic regression was used to assess the adjusted odds ratios (aOR) of adverse outcomes in different age groups in comparison to women aged 20 to 24 years. The adjustments included the location of the hospital, educational level, and residence status. Clinically cutoff age was defined as the age above which the aOR continuously become both...
Source: Chinese Medical Journal - January 13, 2020 Category: General Medicine Authors: Zhang XL, Liang H, Zhao HQ, Wu SW, Zhou QJ, Li XT Tags: Chin Med J (Engl) Source Type: research

A Comparison of the Autologous Platelet-Rich Plasma Gel Fat Graft Myringoplasty and the Fat Graft Myringoplasty for the Closure of Different Sizes of Tympanic Membrane Perforations.
CONCLUSIONS: This study demonstrated that autologous PRPG application during FGM allows for a higher success rate than FGM alone. Furthermore, the use of PRPG with FGM for large perforations increases the success rate. Further studies are needed to investigate the PRPG healing effect on other tympanic membrane perforation closure techniques. PMID: 31928083 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - January 13, 2020 Category: ENT & OMF Authors: Ersözlü T, Gultekin E Tags: Ear Nose Throat J Source Type: research

Scandcleft Project Trial 3: Comparison of Speech Outcomes in Relation to Sequence in 2-Stage Palatal Repair Procedures in 5-Year-Olds With Unilateral Cleft Lip and Palate.
er A Abstract OBJECTIVE: To compare speech outcome following different sequencing of hard and soft palate closure between arms and centers within trial 3 and compare results to peers without cleft palate. DESIGN: A prospective randomized clinical trial. SETTING: Two Norwegian and 2 British centers. PARTICIPANTS: One hundred thirty-six 5-year-olds with unilateral cleft lip and palate were randomized to either lip and soft palate closure at 3 to 4 months and hard palate closure at 12 months (arm A) or lip and hard palate closure at 3 to 4 months and soft palate closure at 12 months (arm D). MAIN ...
Source: The Cleft Palate-Craniofacial Journal - January 13, 2020 Category: ENT & OMF Authors: Persson C, Pedersen NH, Hayden C, Bowden M, Aukner R, Vindenes HA, Åbyholm F, Withby D, Willadsen E, Lohmander A Tags: Cleft Palate Craniofac J Source Type: research

Is there an association between the parameters of arterial stifness and tinnitus?
kcay M, Terzi O Abstract Background: Increasing arterial stiffness is associated with atherosclerosis and there is an association between atherosclerosis and tinnitus may occur.Objectives: The aim of this study was to investigate the relationship between arterial stiffness and tinnitus using the central pulse-wave analysis method.Methods: This prospective, single center study included 98 participants, comprising 49 patients diagnosed with subjective idiopathic tinnitus (Group 1) and a control group of 49 healthy subjects (Group 2). The Mobil-O-Graph 24 h Pulse wave analysis (PWA) Monitor (I.E.M. GmbH, Stolb...
Source: Acta Oto-Laryngologica - January 13, 2020 Category: ENT & OMF Authors: Gedikli Ö, Kemal O, Yıldırım U, Çeçen AB, Karabulut H, Akcay M, Terzi O Tags: Acta Otolaryngol Source Type: research

The number of FoxP3-positive tumor-infiltrating lymphocytes in patients with synchronous bilateral breast cancer.
CONCLUSIONS: There was no relationship between FoxP3+ TIL numbers and cancer progression as reflected in tumor size and axillary lymph node in patients with SBBC. Aggressive biological factors, especially high NG, were significantly related to enhanced recruitment of FoxP3+ TILs. PMID: 31933123 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - January 13, 2020 Category: Cancer & Oncology Authors: Goto R, Hirota Y, Aruga T, Horiguchi S, Miura S, Nakamura S, Takimoto M Tags: Breast Cancer Source Type: research

Fat necrosis in level I oncoplastic breast-conserving surgery focusing on a modified round block technique.
Abstract The modified round block technique (MRBT) is a level I oncoplastic breast-conserving surgery (OBCS), which contains a very wide glandular flap created by extensive dual-plane undermining that is achieved by entire subcutaneous dissection and approximately 50% dissection of the breast parenchyma from the pectoralis muscle. A retrospective analysis was performed for 100 patients who underwent OBCS using MRBT from February 2009 to October 2017. The incidence of positive margin was 7.0% (seven cases), and there has been no local recurrence during a median follow-up period of 68 months. Short- and long-te...
Source: Breast Cancer - January 13, 2020 Category: Cancer & Oncology Authors: Zaha H, Motonari T, Abe N, Unesoko M Tags: Breast Cancer Source Type: research

Correlating cognitive functions to symptom domains and insight in Egyptian patients with schizophrenia.
CONCLUSION: Cognitive impairment in patients with schizophrenia is most likely to underlie negative symptoms, general psychopathology symptoms and poor insight, suggesting that treatment strategies minimizing these symptoms would improve cognitive impairment. PMID: 31928181 [PubMed - as supplied by publisher] (Source: The International Journal of Social Psychiatry)
Source: The International Journal of Social Psychiatry - January 13, 2020 Category: Psychiatry Authors: Khalil AH, El-Meguid MA, Bastawy M, Rabei S, Ali R, Abd Elmoneam MHE Tags: Int J Soc Psychiatry Source Type: research

Visualization of endometriosis with laparoscopy and near ‐infrared optics with indocyanine green
ConclusionsThe diagnostic value of NIR ‐ICG imaging in identifying endometriosis appears to be minimal. ICG exposure time over 20 minutes, no previous abdominal surgery, and low rASRM stages have a significant positive effect on the ICG detection rate. NIR fluorescence imaging with ICG was helpful in the resection of deep infiltrating nodules by providing a better visualization of endometriosis. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 13, 2020 Category: OBGYN Authors: Franziska Siegenthaler, Laura Knabben, Stefan Mohr, Konstantinos Nirgianakis, Sara Imboden, Michael D. Mueller Tags: ORIGINAL RESEARCH ARTICLE Source Type: research