Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population.
Conclusion: In Thai population, our study showed no evidence of association between RAAS-related genes and hypertension. While our study is the first and largest study to investigate the role of RAAS-related genes in hypertension in Thai population, restricted statistical power due to limited sample size is a limitation. PMID: 31511791 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - September 13, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension.
Authors: Azegami T, Itoh H Abstract Hypertension is a global public health issue and the most important preventable cause of cardiovascular diseases. Despite the clinical availability of many antihypertensive drugs, many hypertensive patients have poor medication adherence and blood pressure control due, at least partially, to the asymptomatic and chronic characteristics of hypertension. Immunotherapeutic approaches have the potential to improve medication adherence in hypertension because they induce prolonged therapeutic effects and need a low frequency of administration. The first attempts to reduce blood pressu...
Source: International Journal of Hypertension - September 7, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure.
This study is registered at ClinicalTrials.gov NCT01974570. PMID: 31467699 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - August 31, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Impact of Patient Beliefs on Blood Pressure Control in the General Population: Findings from the Population-Based STAAB Cohort Study.
Conclusion. Beliefs regarding the necessity of prescribed medication did not affect hypertension control. An inverse association between concerns about medication and inappropriately controlled hypertension was found for women only. Our findings highlight that medication-related beliefs constitute a serious barrier of successful implementation of treatment guidelines and underline the role of educational interventions taking into account sex-related differences. PMID: 31467700 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - August 31, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Feasibility of Screening Primary Aldosteronism by Aldosterone-to-Direct Renin Concentration Ratio Derived from Chemiluminescent Immunoassay Measurement: Diagnostic Accuracy and Cutoff Value.
Authors: Li T, Ma Y, Zhang Y, Liu Y, Fu T, Zhang R, Kang K, Yang Y, Wang L, Jiang Y, Lu Y Abstract Objectives: Aldosterone-to-plasma renin activity ratio (ARR) derived from traditional radioimmunoassay (RIA) is widely used to detect primary aldosteronism (PA). Recently, aldosterone-to-direct renin concentration ratio (ADRR), which is calculated by direct renin concentration (DRC) measured by chemiluminescent immunoassay (CLIA), is proposed to replace ARR as the screening test method for PA. The purpose of the present study was to estimate the diagnostic accuracy and cutoff value of ADRR as screening test for PA. ...
Source: International Journal of Hypertension - July 31, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Gender Difference of the Relationship between Arterial Stiffness and Blood Pressure Variability in Participants in Prehypertension.
Authors: Lan Y, Liu H, Liu J, Zhao H, Wang H Abstract Aim. The association of pressure load with elasticity in vascular system has not been studied fully. We proposed a hypothesis whether gender could modify the association of blood pressure variability (BPV) and arterial stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) in prehypertensive patients. Methods. 24h ambulatory blood pressure monitoring (24h-ABPM) and CF-PWV were measured in 723 participants with prehypertension. Univariate and multivariate regression analyses of these clinical and biological parameters were performed in total populatio...
Source: International Journal of Hypertension - July 27, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

The Additive Interaction between Body Mass Index and Hypertension Family History in Han and Yugur: The China National Health Survey (CNHS).
Conclusions: BMI and FHH were associated with hypertension, and the interaction of BMI and FHH on hypertension was significant in Han but not in Yugur people. Behavioural risk factors had little influence on the associations and interactions. The exacerbation of hypertension risks by overweight or obesity in hypertension families deserves attention in weight control and community care. PMID: 31316827 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - July 20, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Predictors of Hypertension among Adult Female Population in Kpone-Katamanso District, Ghana.
The objective of this study was to estimate the prevalence of the problem and other factors related to hypertension among women who are 25 years and above. Methods. A community-based cross-sectional study was conducted from September and November 2017. A multistage cluster sampling technique was used to select the study participants. The data was collected using a structured questionnaire and physical measurements adapted from "WHO STEPwise approach to chronic disease risk factor surveillance (STEPS)." Data were examined using the SPSS program IBM version 20. Descriptive statistics, including proportions, frequen...
Source: International Journal of Hypertension - July 18, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Prevalence and Challenges of Hypertensive Heart Diseases in the Real World.
Authors: Hu K, Shen C, Yu Q PMID: 31281672 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - July 11, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Prevalence of Hypertension and Associated Factors in Dire Dawa City, Eastern Ethiopia: A Community-Based Cross-Sectional Study.
This study was aimed at assessing the prevalence and factors associated with hypertension. Methods: Community-based cross-sectional study was conducted among 903 adults aged 25 to 64 years in Dire Dawa City, East Ethiopia. Data were collected using World Health Organization (WHO) STEPwise approach to Surveillance (STEPS) for non-communicable disease (NCD) standard survey tool. Multivariate logistic regression models were used to identify relative effects of distal, proximal, and immediate risk factors of hypertension, and all statistical tests were declared significantly at P-value
Source: International Journal of Hypertension - June 22, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

A Comparison on Prevalence of Hypertension and Related Risk Factors between Island and Rural Residents of Dalian City, China.
This study aimed to compare the prevalence of hypertension between the island and rural residents in Dalian, China, and to explore associated risk factors of hypertension in order to provide evidence for the establishment of targeted strategy of hypertension prevention and treatment for island and rural residents. The modified MONICA questionnaire survey was performed on 7764 island and rural residents aged ≥40 years (including 2652 island residents and 5112 rural residents). Our data showed that totally weighted prevalence of hypertension was significantly higher in rural residents than in island residents (61.9% vs. 55.2%, P
Source: International Journal of Hypertension - June 21, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Selective Blood Pressure Screening in the Young: Quantification of Population Wide Underestimation of Elevated Blood Pressure.
In conclusion our results show a large screening gap that would result from selective BP screening only in those with overweight, obesity, or parental hypertension. PMID: 31186951 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - June 14, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker?
Authors: Tanase DM, Gosav EM, Radu S, Ouatu A, Rezus C, Ciocoiu M, Costea CF, Floria M Abstract Hypertension as a multifactorial pathology is one of the most important cardiovascular risk factors, affecting up to 30-40% of the general population. Complex immune responses are involved in the inflammatory mechanism of hypertension, with evidence pointing to increased inflammatory mediators even in prehypertensive patients. Increased vascular permeability, thrombogenesis, and fibrosis, effects that are associated with sustained hypertension, could be attributed to chronic inflammation. Chronic inflammation triggers en...
Source: International Journal of Hypertension - June 14, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Hypertension in Jordan: Prevalence, Awareness, Control, and Its Associated Factors.
This study included a total of 1193 men and 2863 women aged ranged from 18 to 90 year with a mean (SD) of 43.8 (14.2) year. The age-standardized prevalence was 33.8% among men and 29.4% among women. Of those with hypertnsion, 57.7% of men and 62.5% of women were aware of hypertension. Only 30.7% of men and 35.1% of women who were on antihypertensive medications had their blood pressure controlled. From 2009 to 2017, there was nonsignificant decrease in hypertension prevalence of 2.7% among men and 1.1% among women. However, the rate of hypertension awareness increased significantly among men and among women. Discussion...
Source: International Journal of Hypertension - June 14, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Comment on "Pulmonary Function Tests in Hypertensive Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia".
Comment on "Pulmonary Function Tests in Hypertensive Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia". Int J Hypertens. 2019;2019:5167018 Authors: Şener YZ, Hekimsoy V, Okşul M PMID: 31080669 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - May 15, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Mobile Phone-Based Intervention in Hypertension Management.
Authors: Andre N, Wibawanti R, Siswanto BB Abstract Hypertension is known as the major risk factor for cardiovascular mortality and morbidity. Antihypertensive agents are directed to prevent many of the harmful effects of elevated blood pressure, yet medication nonadherence hinders the effectiveness of these therapies. Nowadays the use of mobile phone has vastly spread among communities. The rapid adoption of smartphone technology creates a promising and interesting platform to overcome medication nonadherence. This review aimed to critically appraise whether mobile phone-based interventions are effective in increa...
Source: International Journal of Hypertension - May 15, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

PPAR δ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension.
PPARδ: A Potential Therapeutic Target for the Treatment of Metabolic Hypertension. Int J Hypertens. 2019;2019:7809216 Authors: Jiang Y, Li Q, Jia M, Yan Z Abstract High blood pressure and its associated cardiovascular diseases have been major risks for public health. Multiple metabolic risk factors can cause the vascular dysfunction and vascular lesion, and the hypertension due to metabolic disturbances was defined as metabolic hypertension. The members of a subfamily of the nuclear receptors, peroxisome proliferator-activated receptors (PPARs), were found to be key regulators of metabolism and v...
Source: International Journal of Hypertension - May 12, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

The Investigation of Sex Differences in the Effect of Body Mass Index.
Authors: Xiao X, Wang W, Sa R, Qiu L, Liu F Abstract Although many researches regarding risk factors for hypertension have been reported, little information is known about the effect of BMI on the prevalence of hypertension considering sex differences. The aim of this study was to examine the sex difference in the prevalence of hypertension with the predicting indicator BMI. A total number of 6330 subjects in Shaanxi were examined using multivariable logistic regression to study the relationship between genders in different levels of BMI and prevalence of hypertension. Overall, females had a higher prevalence of hy...
Source: International Journal of Hypertension - May 8, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Arterial Hemodynamics in Prehypertensives.
Authors: Ting CT, Chen JW, Chang MS, Yin FC Abstract Compared to age-matched normotensive adults, those with essential hypertension have been shown to have distinct arterial hemodynamic abnormalities consisting of increased peripheral resistance, pulse wave velocity, and wave reflection magnitude as well as decreased wave reflection time and aortic compliance. These abnormalities are further exacerbated by beta-adrenergic blockade. To see if there are similar hemodynamic abnormalities that antedate the onset of fixed hypertension, we compared age-matched normotensives with prehypertensives selected from patients un...
Source: International Journal of Hypertension - May 8, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials.
In conclusion, we confirm that NO restriction associated with hypertension induces a severe pathological phenotype and shows that L-NAME induced stiffening is more pronounced in AA than in TA as a result of greater fibrosis. PMID: 31016040 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 26, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Nonpharmacologic Interventions in Prevention and Treatment of Hypertension.
Authors: Erejuwa OO, Gan SH, Romani AMP, Kamal MA, Nammi S PMID: 31001431 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 21, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review.
This article reviews the research from 2000 to 2018 regarding the mechanism of acupuncture for hypertension, and we summarize the current knowledge about using acupuncture for hypertension. We found that the mechanism whereby acupuncture lowers blood pressure is related to the regulation of renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, neuroendocrine system, and so on. Besides, there may be cross-talk between multiple systems and multiple targets. We also investigate the influence factors of acupuncture for hypertension. These results may provide evidence and research ideas for the treatment...
Source: International Journal of Hypertension - April 16, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Database Analysis of Eplerenone Use in Japanese Hypertensive Patients in Clinical Practice.
Authors: Takahashi S, Ii Y, Yamamoto Y, Ikeda A, Fujimoto Y Abstract Eplerenone, a mineralocorticoid receptor antagonist (MRA), is available in Japan, but details of its use in clinical settings have not been thoroughly investigated. Thus, this study was aimed at examining the characteristics of eplerenone-prescribed hypertensive patients in Japan, describing the combination patterns of antihypertensive medications, and comparing eplerenone's mean doses with respect to concomitant diseases. Data of 160,992 hypertensive patients who used the same drugs for six months or more were collected from an insurance database...
Source: International Journal of Hypertension - April 5, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Arterial Destiffening Starts Early after Renal Artery Denervation.
Conclusions: Early and sustained effects on AoPWV observed in our study suggest that RDN may have additional effects on reducing arterial stiffness and cardiovascular risk. PMID: 30941209 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - April 5, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Heart Rate in Hypertension: Review and Expert Opinion.
Authors: Dalal J, Dasbiswas A, Sathyamurthy I, Maddury SR, Kerkar P, Bansal S, Thomas J, Mandal SC, Mookerjee S, Natarajan S, Kumar V, Chandra N, Khan A, Vijayakumar R, Sawhney JPS Abstract Heart rate (HR) is strongly associated with both peripheral and central blood pressures. This association has implications in hypertension (HTN) prognosis and management. Elevated HR in HTN further elevates the risk of adverse outcomes. Evidence suggests that HR is an independent risk factor for cardiovascular (CV) and total mortality in patients with HTN. With objective to engage physicians and researchers in India to identify ...
Source: International Journal of Hypertension - March 29, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study.
We examined the associations of E158K, along with rare and low frequency exonic variants (minor allele frequency [MAF]
Source: International Journal of Hypertension - March 26, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Safety and Efficacy of a New Renal Denervation Catheter in Hypertensive Patients in the Absent of Antihypertensive Medications: A Pilot Study.
Authors: Li Y, Nawabi AQ, Feng Y, Dai Q, Ma G, Liu N Abstract Aim: The aim of present study was to determine the safety and efficacy of a new renal artery denervation system for treatment of hypertensive patients. Methods: Hypertensive patients with mean office systolic blood pressure ≥150mmHg and ≤180mmHg or an average of 24-hour ambulatory systolic blood pressure ≥145mmHg and ≤170mmHg after stopping hypertensive medications for 2 weeks or more were enrolled to undergo renal denervation (RDN) using a new RDN system. Changes in office blood pressure and mean 24-hour ambulatory blood pressure and saf...
Source: International Journal of Hypertension - March 26, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Chronic Kidney Disease and Pulse Wave Velocity: A Narrative Review.
Authors: Lioufas N, Hawley CM, Cameron JD, Toussaint ND Abstract Chronic kidney disease (CKD) is associated with excess cardiovascular mortality, resulting from both traditional and nontraditional, CKD-specific, cardiovascular risk factors. Nontraditional risk factors include the entity Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) which is characterised by disorders of bone and mineral metabolism, including biochemical abnormalities of hyperphosphatemia and hyperparathyroidism, renal osteodystrophy, and vascular calcification. Increased arterial stiffness in the CKD population can be attributed amongs...
Source: International Journal of Hypertension - March 26, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Blood Pressure Variability Is Associated with Hearing and Hearing Loss: A Population-Based Study in Males.
Authors: Bao M, Song Y, Cai J, Wu S, Yang X Abstract Blood pressure (BP) has been well documented to be associated with hearing loss previously. However, the role of blood pressure variability (BPV, representing BP fluctuation over a time period) on hearing remains unknown. We aimed to evaluate the relationship between BPV and hearing in Chinese population. We included 8646 male subjects from a population-based study (the Kailuan study). BP was measured every two years at routine physical examinations from 2006 to 2015. Based on five annual BP measurements, BPV was estimated by standard deviation of BP (SD), coeffi...
Source: International Journal of Hypertension - March 15, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease.
Conclusion: Severe hyperuricemia in patients with AVRD may have a negative impact on outcomes of renal revascularization. PMID: 30838132 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - March 7, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Qualitative Study of Barriers to Adherence to Antihypertensive Medication among Rural Women in India.
Conclusions: Socioeconomic barriers for low adherence to antihypertensive medication in women in India are low awareness of hypertension and complications, poor access to care, out-of-pocket payments, borrowing money, lack of insurance, and cost of medicines. PMID: 30809390 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - March 1, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Blood Pressure Classification Using the Method of the Modular Neural Networks.
Authors: Pulido M, Melin P, Prado-Arechiga G Abstract In this paper, we present a new model based on modular neural networks (MNN) to classify a patient's blood pressure level (systolic and diastolic pressure and pulse). Tests are performed with the Levenberg-Marquardt (trainlm) and scaled conjugate gradient backpropagation (traincsg) training methods. The modular neural network architecture is formed by three modules. In the first module we consider the diastolic pressure data; in the second module we use details of the systolic pressure; in the third module, pulse data is used and the response integration is perf...
Source: International Journal of Hypertension - March 1, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Prevalence, Awareness, and Control of Hypertension in Greater Beirut Area, Lebanon.
Conclusion: The trend in the prevalence of HTN in Greater Beirut Area is found to be consistent and relatively high, yet there was an observed improvement in the awareness and control of the disease. Public health measures on a national level are urgently needed to curb the increasing prevalence of HTN, achieve primary prevention, and better control the disease. PMID: 30729041 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - February 9, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Personality Traits, Clinical Characteristics, and Health-Related Quality of Life of Patients with Hypertension in a Primary Hospital in Ghana.
Conclusion: This study has demonstrated that clinical characteristics and patients' perception of their personality are relevant to their health-related quality of life outcomes. The findings suggest that when intervention efforts to improve the quality of life of patients with hypertension are being considered, a biopsychosocial approach should be employed. The implication is that treatment of hypertension in Ghana should be broadened to include the expertise of mental health professionals. PMID: 30719339 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - February 7, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

How May Coexisting Frailty Influence Adherence to Treatment in Elderly Hypertensive Patients?
Authors: Uchmanowicz B, Chudiak A, Uchmanowicz I, Mazur G Abstract Background: Hypertension is considered to be the most common condition in the general population. It is the most important risk factor for premature deaths in the world. Treatment compliance at every stage is a condition for successful antihypertensive therapy, and improving the effectiveness of treatment is a major goal in preventing cardiovascular incidents. Treatment noncompliance and lack of cooperation stem from numerous problems of older age, including frailty syndrome. Objective: To evaluate the effect of frailty syndrome on treatment com...
Source: International Journal of Hypertension - February 7, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Effect of BMI and Its Optimal Cut-Off Value in Identifying Hypertension in Uyghur and Han Chinese: A Biethnic Study from the China National Health Survey (CNHS).
Conclusions: Adiposity had strong effect on hypertension, but this effect was less strong in Uyghur female than in Han female. PMID: 30643642 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - January 17, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Association of Urinary Sodium Excretion with Vascular Damage: A Local Kidney Effect, Rather Than a Marker of Generalized Vascular Impairment.
Authors: Triantafyllou A, Anyfanti P, Gkaliagkousi E, Zabulis X, Vamvakis A, Gkolias V, Petidis K, Aslanidis S, Douma S Abstract Evidence suggests that increased salt consumption induces blood pressure- (BP) mediated organ damage, yet it remains unclear whether it reflects a generalized micro- and macrovascular malfunction independent of BP. We studied 197 newly diagnosed and never-treated individuals with hypertension, intermediate hypertensive phenotypes, and normal BP, classified by use of 24-hour ambulatory BP monitoring. Sodium excretion and microalbuminuria were estimated in 24-hour urine samples, dermal capi...
Source: International Journal of Hypertension - January 17, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Blood Pressure in relation to 24-Hour Urinary Sodium and Potassium Excretion in a Uruguayan Population Sample.
Authors: Moliterno P, Álvarez-Vaz R, Pécora M, Luzardo L, Borgarello L, Olascoaga A, Marino C, Noboa O, Staessen JA, Boggia J Abstract Many public health policies in Latin America target an optimized sodium and potassium intake. The aims of this study were to assess the sodium and potassium intake using 24-hour urinary analysis and to study their association with blood pressure in a Uruguayan population cohort using cluster analysis. A total of 149 participants (aged 20-85 years) were included in the study, and office blood pressure, anthropometric measurements, biochemical parameters in the blood, an...
Source: International Journal of Hypertension - January 13, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

The Association of Vitamin A and Vitamin D with Hypertension in Children: A Case-Control Study.
Authors: Liang X, Chen M, Qu P, Hao G, Huang Y, Chen J, Li T Abstract Background: The prevalence of hypertension in children increases rapidly. This paper is to investigate the association of vitamin A and serum 25(OH)D level with hypertension and to explore the risk factors of hypertension in children. Methods: 164 children (age: 6-12 years, females: 49.39%) were included in this case-control study. The serum vitamin A and serum 25(OH)D level, the transcription level of RARs and RXRs, 25(OH)D receptor, and the retinol acyltransferase (LRAT), an indicator of vitamin A storage function, were measured. Result...
Source: International Journal of Hypertension - January 13, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

A Fortified Method to Screen and Detect Left Ventricular Hypertrophy in Asymptomatic Hypertensive Adults: A Korean Retrospective, Cross-Sectional Study.
Authors: Park HE, Chon SB, Na SH, Lee H, Choi SY Abstract Purpose: Left ventricular (LV) mass is determined by the wall thickness and diameter. LV hypertrophy (LVH), the increase in LV mass, is usually screened with electrocardiography but is often insensitive. We tried to fortify the rule to detect LVH using cardiothoracic ratio (CTR) in chest X-ray and well-known risk factors besides electrocardiography. Materials and Methods: This retrospective cross-sectional study included asymptomatic hypertensive individuals aged ≥40 y who underwent voluntary checkups including echocardiography. Independent var...
Source: International Journal of Hypertension - January 1, 2019 Category: Cardiology Tags: Int J Hypertens Source Type: research

Oral Fludrocortisone Test for Salt-Sensitive Screening in Hypertensive Patients: A Randomized Crossover Trial.
Authors: Pio-Abreu A, de Castro I, da Silva GV, Ortega KC, Mion D Abstract Background: Salt sensitivity is associated with an increased cardiovascular risk, but the gold standard method (diet cycles) requires 24-h urine samples and has poor patient compliance. Objectives: Test the hypothesis that oral fludrocortisone (0.4 mg per day for 7 days) is a good alternative in identifying salt-sensitive patients. Methodology: We conducted a randomized crossover study with 30 hypertensive individuals comprising the following steps: (1) washout; (2) phase A (low- and high-sodium diet cycles); (3) washout 2; (4) phase...
Source: International Journal of Hypertension - December 26, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Pulmonary Function Tests in Hypertensive Patients Attending Zewditu Memorial Hospital, Addis Ababa, Ethiopia.
Authors: Birhan MM, Abebe Y Abstract Background: Hypertension imposes stresses on many organs like heart and kidney. However, studies that show the effect of hypertension on the lungs are limited. Objective: To assess pulmonary function status of hypertensive patients aged 30-64 years at Zewditu Memorial Hospital, 2017. Methods: Hospital based comparative cross-sectional study was conducted on 61 hypertensive patients (cases) and 61 nonhypertensive clients (controls) aged 30-64 years. Computerized spirometry was done in all cases and controls which were selected by systematic sampling technique. The study w...
Source: International Journal of Hypertension - December 14, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Hypertension Is an Independent Predictor of Multivessel Coronary Artery Disease in Young Adults with Acute Coronary Syndrome.
Authors: Ge J, Li J, Yu H, Hou B Abstract Background: Risk factors of multivessel coronary artery disease (CAD) among young acute coronary syndrome (ACS) patients remain elusive now. Methods: This retrospective study analyzed data from 187 consecutive young (age ≤45 years) ACS patients (75 STEMI, 30 NSTEMI, and 72 unstable angina) hospitalized in our hospital from January 2012 to December 2016. Thirty-six young male patients with normal coronary angiography (CAG) findings (no-CAD), who underwent CAG due to suspected chest pain in this period, served as control group. There were 83 patients with single-vessel...
Source: International Journal of Hypertension - December 14, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi-South District: A Cross-Sectional Descriptive Study at the St. Elizabeth Hospital, Hwidiem.
Conclusion: Renal dysfunction is common among people living with hypertension in the Asutifi-South District of the Brong Ahafo Region. Femininity, older age, disease comorbidity with diabetes, Thiazide diuretic and AR Blocker usage, and increasing duration of medication accounted for higher kidney dysfunction. Regular screening and management are therefore recommended to avert progression to end-stage renal failure (ESRD). PMID: 30519488 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - December 8, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Brief Report: Exercise and Blood Pressure in Older Adults-An Updated Look.
Conclusions: Exclusive of changes in DBP congruent with resistance training, exercise (aerobic, resistance, and combined aerobic and resistance) reduces resting SBP and DBP in older adults. These findings have practical implications when considering exercise for the prevention and treatment of raised blood pressure in older adults. PMID: 30510795 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - December 6, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Pulse Pressure Relationships with Demographics and Kidney Function in Ashanti, Ghana.
Authors: Banerjee D, Plange-Rhule J, Chitalia N, Kumi K, Micah FB, Cappuccio FP, Eastwood JB Abstract Introduction: Hypertension, particularly pulse pressure [PP] is a major risk factor for end-stage renal disease. However, the effect of individual components of hypertension namely PP, systolic [SBP] and diastolic blood pressure [DBP] on kidney function, in the general African population is unknown. Methods: Data were collected on 944 participants [aged 40-75 y], living in villages in the area around the city of Kumasi, Ghana, on demographics, medications, height, weight, BP and 24-hour creatinine clearance (Cr...
Source: International Journal of Hypertension - November 9, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Value of Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Hypertensive Patients.
Conclusions: This study indicates impaired autonomic nervous function in hypertensive patients, especially in hypertensive patients with uncontrolled blood pressure despite guideline recommended antihypertensive medications. PMID: 30405909 [PubMed] (Source: International Journal of Hypertension)
Source: International Journal of Hypertension - November 9, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Tracking of Blood Pressure in Children and Adolescents in Germany in the Context of Risk Factors for Hypertension.
This study investigates BP tracking in children and adolescents in Germany in the context of hypertension risk factors. BP was measured and analyzed in 2542 participants of the German Health Examination Survey for Children and Adolescents (t0 2003-2006; 3 to 17-year olds) and of a six year follow-up "Motorik Modul" (t1 2009-2012; 9 to 24-year olds). BP tracking coefficients were calculated from Spearman's rank-order correlations. Predictive values and logistic regression models were used to forecast t1-BP above the hypertension threshold from t0-BP as well as from baseline and follow-up hypertension risk factors....
Source: International Journal of Hypertension - October 26, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

Heart Rate Variability and Cardiovascular Reflex Tests for Assessment of Autonomic Functions in Preeclampsia.
Authors: Chaswal M, Kapoor R, Batra A, Verma S, Yadav BS Abstract Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. The present study was designed to evaluate autonomic functions in preeclamptic pregnant women and compare the values with normotensive pregnant and healthy nonpregnant controls. Assessment of autonomic functions was done by cardiovascular reflex tests and by analysis of heart rate variability (HRV). Cardiovascular reflex tests included deep breathing test (DBT) and lying to standing test (LST). HRV was analyzed in both time an...
Source: International Journal of Hypertension - October 16, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research

The Relationship between Inter-Arm Blood Pressure Difference and Coronary Artery Disease Severity Calculated by the SYNTAX Score.
Authors: Durmuş G, Belen E, Bayyigit A, Kalyoncuoğlu M, Can MM Abstract Objectives: The inter-arm systolic blood pressure difference (IASBPD) is closely related to cardiovascular mortality and morbidity. The SYNTAX score indicates the extent and complexity of coronary artery disease, which are determined by coronary angiography. The aim of our study is to examine the relationship between the IASBPD (which is easily calculated in routine practice) and the SYNTAX score. Methods: 104 patients were included in this cross-sectional study. The IASBPD was calculated by blood pressure measurements obtained simultaneo...
Source: International Journal of Hypertension - October 13, 2018 Category: Cardiology Tags: Int J Hypertens Source Type: research