Diagnostic utility of capnography in emergency department triage for screening acidemia: a pilot study
ConclusionsCapnography is a quantitative method of screening acidemia in patients and can be implemented feasibly in Emergency Department triage as an adjunct to vital signs. While it was shown to have only modest ability to predict acidemia, triage capnography has wide generalizability to screen other life-threatening disease processes such as sepsis or can serve as an early indicator of clinical deterioration. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - April 22, 2024 Category: Emergency Medicine Source Type: research
Sustained Improvements in Clinical and Patient-Reported Outcomes and Quality of Life Through 5 Years Among Ixekizumab-Treated Patients with Complete Clearance of Scalp Psoriasis by Week 60
ConclusionsContinued treatment with ixekizumab provided long-term sustained scalp clearance over 5 years to patients with moderate-to-severe plaque psoriasis and baseline scalp involvement, and holistic improvements occurred across clinical outcomes, patient-reported outcomes, and quality of life.Clinical Trial NumbersNCT01474512 (UNCOVER-1), NCT01597245 (UNCOVER-2), and NCT01646177 (UNCOVER-3). (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 22, 2024 Category: Dermatology Source Type: research
Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates
AbstractMerkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine differentiation. Its carcinogenesis is based either on the integration of the Merkel cell polyomavirus or on ultraviolet (UV) mutagenesis, both of which lead to high immunogenicity either through the expression of viral proteins or neoantigens. Despite this immunogenicity resulting from viral or UV-associated carcinogenesis, it exhibits highly aggressive behavior. However, owing to the rarity of MCC and the lack of epidemiologic registries with detailed clinical data, there is some uncertainty regarding the spontaneous course of the d...
Source: American Journal of Clinical Dermatology - April 22, 2024 Category: Dermatology Source Type: research
Plasma neurological biomarkers as a measure of neurotoxicity in pediatric dental general anesthesia: a prospective observational feasibility study
ConclusionCaspase-3 reduced significantly in the short time frames during day-care DGA; this might be due to the relatively short anesthesia duration associated with dental treatment as compared with more extensive medical-related treatments. Therefore, further studies on Caspase-3 as a potential biomarker in pediatric DGA neurotoxicity are required to further ascertain results of this study. (Source: European Archives of Paediatric Dentistry)
Source: European Archives of Paediatric Dentistry - April 22, 2024 Category: Dentistry Source Type: research
Screening and surveillance recommendations for central nervous system hemangioblastomas in pediatric patients with Von Hippel-Lindau disease
ConclusionWe recommend starting MRI imaging at the age of 12 years with examination intervals every (1-) 2 years depending on CNS involvement. Special attention should be paid to patients with truncating variants. Affected families should be educated regularly on potential tumor-associated symptoms to enable timely MRI imaging and eventually intervention, as CNS hemangioblastoma may develop before screening begins.German clinical trials Register registration numberDRKS00029553, date of registration 08/16/2022, retrospectively registered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Focus on Understanding Statistics
(Source: Academic Psychiatry)
Source: Academic Psychiatry - April 22, 2024 Category: Psychiatry Source Type: research
Social characteristics and social benefit use among premenopausal breast cancer survivors in Denmark: a population-based cohort study
ConclusionsUse of social benefits reflecting lost ability to work was highest in less educated women and in women living alone.Implications for Cancer Survivors.Awareness of these groups is crucial when tailoring efforts to support work participation in cancer survivors. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - April 22, 2024 Category: Cancer & Oncology Source Type: research
Off- to in-season body composition adaptations in elite male and female endurance and power event athletics competitors: an observational study
ConclusionsThe present study found that male athletes gained more BM, LM and trunk LM than females. Within-group increases in regional and whole-body LM and BMC were predominantly found among power event competitors. Incorporating individual meaningful changes alongside traditional statistics provided additional insights into sex and event-group differences. Future research on elite athletic event groups should include DXA measurements closer to major outdoor-season competitions, coupled with site-specific measures (ultrasound, MRI) for better detection of subtle changes in LM and FM. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 22, 2024 Category: Sports Medicine Source Type: research
Tunneled Paranasal Augmentation Using Diced Autologous Costal Cartilage in Asian Rhinoplasty: A Comparative Study
This study affirmed that paranasal augmentation using diced costal cartilage in rhinoplasty is a safe procedure effective in remedying paranasal concavity and improving facial satisfaction.
Level of Evidence: IV [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Facial Plastic Surgery)
Source: Facial Plastic Surgery - April 22, 2024 Category: Cosmetic Surgery Authors: Lin, Guangxian Yihao, Xu Zhang, Xulong You, Jianjun Wang, Huan Zheng, Ruobing Tian, Le Guo, Junsheng Song, Zhen Fan, Fei Tags: Original Research Source Type: research
Experimental Investigation of Brain Contusion Characteristics and Dynamic Response in Low-age Children Using an Animal Model
Traumatic brain injury (TBI) has emerged as a significant contributor to both disability and mortality in pediatric populations, primarily resulting from falls, blows and traffic accidents [1]. In cases of TBI among low-age children, the mortality rate can reach as high as 50% [2]. Notably, brain contusion stands out as the predominant form of TBI in this demographic, with an incidence rate reaching 39% [3]. Given these alarming statistics, it is imperative to investigate the characteristics of brain contusion and the dynamic responses of brain to diverse impact conditions. (Source: Injury)
Source: Injury - April 22, 2024 Category: Orthopaedics Authors: Rui Li, Zhongqing Su, Zhigang Li, Dapeng Li, Rutao Luo, Jinlong Qiu, Huiqing Lan Source Type: research
Analysis of the efficacy of separation surgery for severe neurological compression in multiple myeloma: a retrospective analysis of 35 cases
ConclusionsSeparation surgery effectively alleviates pain, improves neurological function, and enhances the quality of life in patients with ESCC graded ≥ 2 due to MM. (Source: European Spine Journal)
Source: European Spine Journal - April 22, 2024 Category: Orthopaedics Source Type: research
Trends in the mortality of intra-abdominal infections in adults over 25 years in the USA, 1999-2021
We examined intra-abdominal infection-related mortality trends from 1999 to 2021, which encompasses the COVID-19 pandemic. Using the National Vital Statistics System (NVSS) database (1999–2021), which registers more than 99% of deaths in the USA, we obtained decedents with intra-abdominal infection, defined as deaths related to acute cholecystitis, acute appendicitis, Clostridioides difficile colitis, diverticulitis or pyelonephritis (multiple causes were possible). Age-standardised mortality rates (ASMR) per 100 000 population were calculated using the 2010 US Census as the standard population. Joinpoint Regression ...
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Liu, Y., Samaan, J. S., Essanaa, Y. M., Lv, F., Ji, F., Samakar, K., Yeo, Y. H. Tags: COVID-19 Research letter Source Type: research
Opportunistic screening in the emergency department
Smoking cessation is currently topical with recent government announcements regarding restricting the sale of disposable vapes and a consultation on raising the legal age of buying tobacco from 18 years, so that anyone born after a certain year will never be able to buy cigarettes legally. This edition of the EMJ contains a randomised controlled multicentre trial of smoking cessation initiated in the emergency department (ED).1 The intervention group received brief smoking cessation advice as well as provision of an e-cigarette starter kit and referral to the local stop smoking services, while the control group received ad...
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: France, J. Tags: Commentary Source Type: research
Using an artificial intelligence software improves emergency medicine physician intracranial haemorrhage detection to radiologist levels
Conclusion
The Caire ICH software significantly improved the accuracy and sensitivity of detecting an ICH by the EP to a level comparable to general radiologists. Further prospective research with larger numbers will be needed to understand the impact of Caire ICH on ED logistics and patient outcomes. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - April 22, 2024 Category: Emergency Medicine Authors: Warman, P., Warman, A., Warman, R., Degnan, A., Blickman, J., Smith, D., McHale, P., Coburn, Z., McCormick, S., Chowdhary, V., Dash, D., Sangal, R., Vadhan, J., Bueso, T., Windisch, T., Neves, G. Tags: Original research Source Type: research
Inconclusiveness of psychometric testing of medication adherence questionnaires
ConclusionResults show that assessing the validity and reliability of adherence questionnaires with standard procedures including statistical tests is inconclusive. Refinement of the constructs of non-adherence is needed in pharmacy and medical practice. We suggest a distinction between the (i)extent of missed doses over the past 2 weeks, (ii)modifiable reasons for non-adherence behavior, and (iii)unmodifiable factors of non-adherence. Validation procedures and corresponding statistical methods should be selected according to the specific single constructs. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
