Multicenter PET image harmonization using generative adversarial networks
CONCLUSIONS: GANs are capable of performing image harmonization and increase reproducibility and predictive performance of radiomic features derived from different centers and scanners.PMID:38696130 | DOI:10.1007/s00259-024-06708-8 (Source: Molecular Medicine)
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: David Haberl Clemens P Spielvogel Zewen Jiang Fanny Orlhac David Iommi Ignasi Carri ó Ir ène Buvat Alexander R Haug Laszlo Papp Source Type: research
Prognostic Factors and Treatment Effect Modifiers for Physical Health, Opioid Prescription, and Health Care Utilization in Patients With Musculoskeletal Disorders in Primary Care: Exploratory Secondary Analysis of the STEMS Randomized Trial of Direct Access to Physical Therapist-Led Care
CONCLUSIONS: Patients with musculoskeletal conditions with lower levels of pain self-efficacy, higher pain severity, and presenting with low back pain have less favorable clinical and health care outcomes in primary care. Prespecified characteristics did not modify the treatment effect of the offer of a direct-access physical therapist-led pathway compared to GP-led care.IMPACT: Patients with musculoskeletal conditions receiving primary care in the form of direct-access physical therapist-led or GP-led care who have lower levels of self-efficacy, higher pain severity, and low back pain are likely to have a less favorable p...
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: James Zouch Nazim Bhimani Andr é Bussières Manuela Ferreira Nadine E Foster Paulo Ferreira Source Type: research
Kinesiophysiological analysis associated with changes in subjective intensities in belt electrode-skeletal muscle electrical stimulation: a prospective exploratory study
Conclusion] These findings show that objective intensities of >3 METs, as recommended in rehabilitation prescriptions, can be achieved when the subjective intensity is set at strong or maximum tolerated. Treatment with B-SES may provide a viable alternative to therapeutic exercise.PMID:38694009 | PMC:PMC11060770 | DOI:10.1589/jpts.36.284 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Norikazu Hishikawa Koshiro Sawada Motonori Kubo Mari Kakita Takashi Kawasaki Suzuyo Ohashi Yasuo Mikami Source Type: research
Real-world environmental enrichment rehabilitation paradigm in people with severe traumatic brain injury: a pilot feasibility study
CONCLUSION: The Café was a comprehensive EE-based intervention that was feasible, safe, and has the potential to enhance motor and cognitive function in individuals with brain injury.PMID:38695288 | DOI:10.1080/02699052.2024.2347551 (Source: Brain Injury)
Source: Brain Injury - May 2, 2024 Category: Neurology Authors: Devina S Kumar Barry A Bodt James C Galloway Source Type: research
Predictive DNA damage signaling for low ‑dose ionizing radiation
Int J Mol Med. 2024 Jun;53(6):56. doi: 10.3892/ijmm.2024.5380. Epub 2024 May 2.ABSTRACTNumerous studies have attempted to develop biological markers for the response to radiation for broad and straightforward application in the field of radiation. Based on a public database, the present study selected several molecules involved in the DNA damage repair response, cell cycle regulation and cytokine signaling as promising candidates for low‑dose radiation‑sensitive markers. The HuT 78 and IM‑9 cell lines were irradiated in a concentration‑dependent manner, and the expression of these molecules was analyzed using weste...
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Jeong-In Park Seung-Youn Jung Kyung-Hee Song Dong-Hyeon Lee Jiyeon Ahn Sang-Gu Hwang In-Su Jung Dae-Seog Lim Jie-Young Song Source Type: research
Prolonged Opioid Use Is Associated With Poor Pain Alleviation After Orthopaedic Surgery
CONCLUSION: Our findings demonstrated an overall high rate of COU. The known risk factors of COU were evident in our study population, particularly the modifiable risk factor of acute postsurgical PPA. Better management of postsurgical pain in orthopaedic patients may lead to a decrease in the rates of COU in this group.PMID:38696825 | DOI:10.5435/JAAOS-D-24-00044 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - May 2, 2024 Category: Orthopaedics Authors: Meir T Marmor Stephanie Hu Varun Mahadevan Alexander Floren Belen Perez Solans Rada Savic Source Type: research
Effectiveness of autologous fibrin glue in preventing post-thoracotomy air leaks: a randomized controlled trial
CONCLUSIONS: The application of autologous fibrin glue during thoracotomy procedures significantly reduces postoperative air leaks and hospitalization duration without increasing complication rates. This finding suggests a beneficial role of fibrin glue in thoracic procedures requiring lung resection or decortication.PMID:38693984 | PMC:PMC11059015 | DOI:10.5114/kitp.2024.138579 (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Fariba Zabihi Ali Mehri Ghazale Ahmadi Daryoush Hamidi Alamdari Mona Kabiri Azam Amirianfar Reza Rezaei Source Type: research
Premorbid functional status in patients requiring veno-arterial extracorporeal membrane oxygenation after cardiac surgery
Int J Artif Organs. 2024 May 1:3913988241247652. doi: 10.1177/03913988241247652. Online ahead of print.ABSTRACTAssessment of a patient's functional status prior to undergoing cardiac surgery may be a useful marker for predicting outcomes when postoperative veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is required. In this short communication, we present retrospective data on 83 patients at a single center who required V-A ECMO after cardiac surgery. Our results did not show a statistically significant association between premorbid functional status and mortality, though age was predictive of mortality. Futur...
Source: The International Journal of Artificial Organs - May 2, 2024 Category: Transplant Surgery Authors: AlleaBelle Bradshaw Jessica Briscoe Kavya Sanghavi Blake Taurone Nidhi Vantair Jacob Gilbreth Akram M Zaaqoq Source Type: research
Bicycling for Rehabilitation of Persons With Parkinson Disease: A Scoping Review
CONCLUSIONS: The literature on bicycling for PwPD has evolved from speed to aerobic studies. The terminology describing types of bicycling was simplified. Of all the outcomes reported, reduction of disease severity achieved the highest frequency of clinical meaningful improvements. Bicycling was comparable with other forms of aerobic training for walking speed and endurance. Opportunities for translation to practice and research are presented.VIDEO ABSTRACT AVAILABLE: for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A462).PMID:38693613 | DOI:10.1097/N...
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: John L Palmieri Lesley Jones Margaret Schenkman Judith E Deutsch Source Type: research
Genetic variations in immune mediators and prostate cancer risk: A field synopsis with Bayesian calculations
CONCLUSION: In conclusion, this current Bayesian revaluation showed that the rs1143627 and the rs1946518 polymorphisms in the IL1B and IL18 genes, respectively, were noteworthy biomarker candidates for PCa risk.PMID:38696882 | DOI:10.1016/j.cyto.2024.156630 (Source: Cytokine)
Source: Cytokine - May 2, 2024 Category: Molecular Biology Authors: Matheus Santos Freire Andr é Victor de Oliveira Monteiro Tayane Moura Martins M árcia Socorro Silva Lima Duarte Antonio Carlos Lima Alessandro Luiz Ara újo Bentes Leal Felipe Rodolfo Pereira da Silva Jos é Fernando Marques Barcellos Source Type: research
Estimating genomic relationships of metafounders across and within breeds using maximum likelihood, pseudo-expectation-maximization maximum likelihood and increase of relationships
CONCLUSIONS: We derived ML, pseudo-EM and pseudo-EM+ Δ F methods to estimate Γ in many realistic settings. Estimates are accurate in real and simulated data and have a low computational cost.PMID:38698347 | DOI:10.1186/s12711-024-00892-9 (Source: Genet Sel Evol)
Source: Genet Sel Evol - May 2, 2024 Category: Genetics & Stem Cells Authors: Andres Legarra Matias Bermann Quanshun Mei Ole F Christensen Source Type: research
The possible causal relationship between COVID-19 and imaging markers of cerebral small vessel disease: a Mendelian randomization study
This study aims to explore the causal correlation between COVID-19 and the imaging markers of CSVD using Mendelian randomization (MR) methods.METHODS: Summary-level genome-wide association study (GWAS) statistics for COVID-19 susceptibility, hospitalization, and severity were utilized as proxies for exposure. Large-scale meta-analysis GWAS data on three neuroimaging markers of white matter hyperintensity, lacunar stroke, and brain microbleeds, were employed as outcomes. Our primary MR analysis employed the inverse variance weighted (IVW) approach, supplemented by MR-Egger, weighted median, and MR-PRESSO methods. We also co...
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Jiahao Song Da Zhou Lina Jia Mengqi Wang Duo Lan Jingrun Li Fatime Zara Hassan Hamit Yuchuan Ding Xunming Ji Ran Meng Source Type: research
Neighborhood physical environments and change in cardiometabolic risk factors over 14 years in the study of Women's health across the nation
CONCLUSION: Neighborhood walkability may have a meaningful influence on trajectories of blood pressure outcomes in women from midlife to early older adulthood, suggesting the need to better understand how individuals interact with their neighborhood environments in pursuit of cardiometabolic health.PMID:38696876 | DOI:10.1016/j.healthplace.2024.103257 (Source: Health and Place)
Source: Health and Place - May 2, 2024 Category: Environmental Health Authors: Bradley M Appelhans Brittney S Lange-Maia Chen Yeh Elizabeth A Jackson Mary D Schiff Emma Barinas-Mitchell Carol A Derby Carrie A Karvonen-Gutierrez Imke Janssen Source Type: research
Standardized multi-institutional data analysis of fixed and removable prosthesis: estimation of life expectancy with regards to variable risk factors
CONCLUSION: Life expectancy of a prosthesis differed significantly by factors mostly controllable either by dentist or a patient. Overall life expectancy was shown to be longer than previous research.PMID:38694192 | PMC:PMC11058353 | DOI:10.4047/jap.2024.16.2.67 (Source: Adv Data)
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Hae-In Jeon Joon-Ho Yoon Jeong Hoon Kim Dong-Wook Kim Namsik Oh Young-Bum Park Source Type: research
Assessment of serum inflammatory parameters in RRMS and SPMS patients
DISCUSSION: Significant differences were found in BAFF, gp130, MMP-2 and osteopontin levels between RRMS and SPMS patients. Serum IL-32 levels were statistically lower in RRMS patients treated with disease-modifying therapy than in treatment-naïve patients.PMID:38697017 | DOI:10.1080/01616412.2024.2337503 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Maria Nowak-Kiczmer Natalia Niedziela Zenon P Czuba Pawe ł Sowa Krzysztof Wierzbicki Micha ł Lubczyński Monika Adamczyk-Sowa Source Type: research
