A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment
ConclusionRenal impairment had no effect on the metabolism of CBD after a single oral 200  mg dose. CBD was generally well tolerated in subjects with varying degrees of renal function.RegistrationEuropean Union Clinical Trials Register (EudraCT) no. 2015-002122-39. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - December 5, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of mandibular cortical bone among obese, overweight, and normal weight adolescents using panoramic mandibular index and mental index
The objective of this study is to evaluate the mental index (MI) and panoramic mandibular index (PMI) of a group of adolescent patients in different body mass index (BMI) percentile.Material and methodsSubjects were divided into three different groups in accordance to their BMI percentile status: normal weight (35 subjects; mean age, 14.81 ± 2.12 years), overweight (32 subjects; mean age, 14.77 ± 2.56 years), and obese (33 subjects; mean age, 14.06 ± 2.59 years) groups. Mental index (MI) and panoramic mandibular index (PMI) were assessed on panoramic radiographs.ResultsThere were statistically signific...
Source: Clinical Oral Investigations - December 5, 2019 Category: Dentistry Source Type: research

Parental Perception of Children ’s Weight Status: Love Overpasses Scientific Evidence! A Cross-Sectional Observational Study
ConclusionsA high percentage of children is overweight or obese and almost half of parents classified their weight status incorrectly. Increasing children ’s body mass index percentiles decreases the probability to be correctly classified. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - December 5, 2019 Category: Cardiology Source Type: research

Cancers, Vol. 11, Pages 1950: Efficacy and Adverse Events in Metastatic Melanoma Patients Treated with Combination BRAF Plus MEK Inhibitors Versus BRAF Inhibitors: A Systematic Review
ef Zakharia We reviewed the literature to assess the efficacy and risk of constitutional, cardiac, gastrointestinal, and dermatological toxicities of combined BRAF plus MEK inhibitors versus BRAF inhibitors alone in patients with metastatic melanoma with BRAF mutations. Searches were conducted in PubMed, Cochrane Database of Systematic Reviews, Google scholar, ASCO, Scopus, and EMBASE for reports published from January 2010 through March 2019. Efficacy, including progression-free survival (PFS) and overall survival (OS) rates, were assessed by hazard ratio (HR); objective response rates (ORR) were assessed by odds rati...
Source: Cancers - December 5, 2019 Category: Cancer & Oncology Authors: Austin Greco Danish Safi Umang Swami Tim Ginader Mohammed Milhem Yousef Zakharia Tags: Review Source Type: research

Biān stone hot compress combined with acupuncture at cervical Jiājĭ acupoint for axial pain after cervical LIF operation: A randomized controlled trial
Publication date: Available online 4 December 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): De-sheng ZHANG, Pei-rong ZHOU, Shui-chun LIU, Shao-qiu SUNABSTRACTObjectiveTo compare the clinical effect differences of biān (砭) stone hot compress combined with acupuncture at cervical Jiājĭ (夹脊EX-B2) acupoint and simple acupuncture at cervical EX-B2 for axial pain after cervical laminectomy with implant fixation (LIF) operation.MethodsA total of 80 patients with axial pain after cervical LIF operation were randomly assigned into the biān (砭) stone hot compress combined with acupuncture at cervical E...
Source: World Journal of Acupuncture Moxibustion - December 4, 2019 Category: Complementary Medicine Source Type: research

Regular acupuncture at combined with join valley needling at ashi point for scapulohumeral periarthritis: a randomized controlled trial
Publication date: Available online 4 December 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Miao ZHANG, Cheng-xin FAN, Peng-yu ZHU, Wen-ting NIE, Hai QINABSTRACTObjectiveTo observe clinical efficacy differences of regular acupuncture at empirical acupoints combined with join valley needling at ashi point compared with simple join valley needling at ashi point for scapulohumeral periarthritis.MethodsSixty-four patients of scapulohumeral periarthritis were randomly divided into an observation group and a control group, 32 cases in each one. Both groups underwent basic rehabilitation training. Patients in t...
Source: World Journal of Acupuncture Moxibustion - December 4, 2019 Category: Complementary Medicine Source Type: research

Wrist-ankle acupuncture combined with pinching along the spine for children allergic rhinitis: A randomized controlled trial
Publication date: Available online 4 December 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Yu LIU, Yi-huang GU, Ying XIONGAbstractObjectiveTo investigate the clinical effect of wrist-ankle acupuncture combined with pinching along the spine on allergic rhinitis (AR) in children.MethodsA total of 65 children with AR were collected from February 2017 through to December 2018 and they were randomly divided into a combined treatment group with wrist-ankle acupuncture, pinching along the spine and western medication (combined treatment group, 32 cases) and a western medication group (33 cases). In the western...
Source: World Journal of Acupuncture Moxibustion - December 4, 2019 Category: Complementary Medicine Source Type: research

Difference in the anti-fatigue effect of moxibustion at different acupoints in one-off exhausted rats
Publication date: Available online 4 December 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Xin Wang, Ya-hui Zhang, Zhi-fang Zhang, Shi-ling Lǚ, Yu-lei Liang, Dong-yun Sun, Tian-yuan LǚAbstractObjectiveTo explore the difference in the anti-fatigue effect of moxibustion at different acupoints through observing the impacts of moxibustion at “Shènshù (肾俞BL23)”, “Zúsānlĭ (足三里ST36)”, “Guānyuán (关元CV4)” and “Shénquè (神阙CV8)” on energy metabolic indexes in the one-off exhausted rats.MethodsA total of...
Source: World Journal of Acupuncture Moxibustion - December 4, 2019 Category: Complementary Medicine Source Type: research

Perioperative complications and mortality in elderly patients following surgery for femoral fracture: prospective observational study
ConclusionsIncreasing age and number of preoperative complications, in addition to ASA classification III or IV, were independent factors of increased risk of death in the population studied. The mortality rate was 30.8%, and infection followed by septic shock was the leading cause of death.ResumoJustificativa e objetivosO manejo perioperatório das fraturas de fêmur em pacientes idosos tem sido estudado com o intuito de determinar causas modificáveis de complicações e óbito. Este estudo tem por objetivo avaliar taxa de mortalidade e suas causas na população idosa com F...
Source: Brazilian Journal of Anesthesiology - December 4, 2019 Category: Anesthesiology Source Type: research

Associations and community health workers: analysis and time trends over ten years of training-action.
CONCLUSIONS: The results of the CHW training-action course improve over time given that a significant increase in participation by associations and women can be seen, along with a greater number of activities completed during the training. One effect of this is that CHWs are contracted or carry out voluntary activities in the associations. PMID: 31787404 [PubMed - as supplied by publisher] (Source: Gaceta Sanitaria)
Source: Gaceta Sanitaria - December 4, 2019 Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research

Guaruman fiber: another possible reinforcement in composites
Publication date: Available online 3 December 2019Source: Journal of Materials Research and TechnologyAuthor(s): Raphael Henrique Morais Reis, Larissa Fernandes Nunes, Michelle Souza Oliveira, Valdir Florêncio de Veiga, Fabio Da Costa Garcia Filho, Miriane Alexandrino Pinheiro, Alisson Clay Rios da Silva, Verônica Scarpini Candido, Sergio Neves MonteiroAbstractNatural lignocellulosic fibers (NLFs) have been investigated, especially in the past decades, as promising reinforcement in composite materials for engineering applications. The interest regarding the use of NLFs is associated with advantages such as low ...
Source: Journal of Materials Research and Technology - December 4, 2019 Category: Materials Science Source Type: research

Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a “Digital” Multi-spectral Lineage Tracing System
This study demonstrates nBitbow as an efficient tool for in situ lineage mapping, and the complete lineage relationship among larval PNS neurons opens new possibilities for studying how neurons gain specific features and circuit connectivity.Graphical Abstract (Source: Cell Reports)
Source: Cell Reports - December 4, 2019 Category: Cytology Source Type: research

Therapeutic Hypothermia: Comparing Surface vs Intravascular Cooling.
DISCUSSION: This review found no difference between intravascular and surface cooling and effects on survival and neurological outcome. More research needs to be performed on the best type of cooling method as well as the best product within each category. PMID: 31789981 [PubMed - in process] (Source: Dimensions in Critical Care Nursing)
Source: Dimensions in Critical Care Nursing - December 4, 2019 Category: Nursing Tags: Dimens Crit Care Nurs Source Type: research

Bridging the Communication Gap: A Quality Improvement Project of a Ventricular Assist Device Program.
CONCLUSION: Implementation of the LVAD Emergency Line has improved communication between patients in the outpatient setting. This increased patient safety by allowing patients to speak to LVAD-trained first responders and VAD coordinator personnel immediately without ever being put on hold. This communication process can be applied to other clinical programs. PMID: 31789980 [PubMed - in process] (Source: Dimensions in Critical Care Nursing)
Source: Dimensions in Critical Care Nursing - December 4, 2019 Category: Nursing Tags: Dimens Crit Care Nurs Source Type: research

Improving Compliance With Protocol-Driven Care in Adult Traumatic Brain Injury Patients by Implementing an Electronic Clinical Compliance Monitoring Tool.
CONCLUSIONS: Traumatic brain injury-specific education and frequent assessments improved compliance between TBI-2012 and TBI-2017, resulting in a higher percentage in overall survivors in the latter group. PMID: 31789987 [PubMed - in process] (Source: Dimensions in Critical Care Nursing)
Source: Dimensions in Critical Care Nursing - December 4, 2019 Category: Nursing Tags: Dimens Crit Care Nurs Source Type: research

Effects of anakinra on the small intestine mucositis induced by methotrexate in rats.
Authors: Ozcicek F, Kara AV, Akbas EM, Kurt N, Yazici GN, Cankaya M, Mammadov R, Ozcicek A, Suleyman H Abstract Intestinal mucositis is an important problem in the patients receiving cancer treatment. We aimed to investigate the effect of anakinra, which is a well known anti-oxidant and anti-inflammatory agent, on methotrexate-induced small intestine mucositis in rats. Forty rats were divided into 4 groups with 10 in each group. The healthy group (HG) and the methotrexate group (MTXG) were given distilled water, while the methotrexate+anakinra 50 (MTX+ANA50) and the methotrexate+anakinra 100 (MTX+ANA100) groups wer...
Source: Experimental Animals - December 4, 2019 Category: Research Tags: Exp Anim Source Type: research

Laterally Placed Expandable Interbody Spacers Improve Radiographic and Clinical Outcomes: A 1-Year Follow-up Study
This study describes the clinical and radiographic outcomes of patients treated with expandable interbody spacers for MIS LLIF.MethodsA retrospective, single surgeon, clinical and radiographic study was performed on 37 consecutive patients who underwent MIS LLIF at 1–2 contiguous level(s) using expandable spacers. Radiographic and clinical functional outcomes were collected and compared at preoperative and postoperative time points up to 12 months. Parametric and nonparametric tests were used when appropriate with p value
Source: Interdisciplinary Neurosurgery - December 4, 2019 Category: Neurosurgery Source Type: research

Analysis of volatile compound change in tuna oil during storage using a laser irradiation based HS-SPME-GC/MS
Publication date: Available online 4 December 2019Source: LWTAuthor(s): Mengna Zhang, Linqiu Li, Gongshuai Song, Honghai Wang, Haixing Wang, Qing ShenAbstractTuna oil (TO) is susceptible to oxidation thus induce unpleasant flavor during storage. Herein, a novel and efficient laser irradiation desorption headspace solid-phase microextraction coupling gas chromatography-mass spectrometry method was developed for fast analysis of flavor change in TO at different storage periods. The data were statistically analyzed by multivariate statistical analyses, including principle component analysis (PCA) and orthogonal partial least-...
Source: LWT Food Science and Technology - December 4, 2019 Category: Food Science Source Type: research

Investigation of ram effect and eCG usage in progesterone based oestrous synchronization protocols on fertility of ewes following fixed time artificial insemination
In conclusion, the 4 protocols investigated were effective in synchronizing oestrus with similar response to synchronization of oestrus and fertility among treatment groups. Of the 4 protocols, the Ramlong protocol offers the benefit of being less costly because of reduced hormonal use in addition to the adequate fertility obtained. (Source: Small Ruminant Research)
Source: Small Ruminant Research - December 4, 2019 Category: Zoology Source Type: research

Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs
Publication date: Available online 4 December 2019Source: Genomics, Proteomics & BioinformaticsAuthor(s): Nicole Ludwig, Tobias Fehlmann, Fabian Kern, Manfred Gogol, Walter Maetzler, Stephanie Deutscher, Simone Gurlit, Claudia Schulte, Anna-Katharina von Thaler, Christian Deuschle, Florian Metzger, Daniela Berg, Ulrike Suenkel, Verena Keller, Christina Backes, Hans-Peter Lenhof, Eckart Meese, Andreas KellerAbstractBlood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures. These have to be val...
Source: Genomics, Proteomics and Bioinformatics - December 4, 2019 Category: Bioinformatics Source Type: research

Neutral competition in a deterministically changing environment: revisiting continuum approaches
Publication date: Available online 3 December 2019Source: Journal of Theoretical BiologyAuthor(s): Ryan Murray, Glenn YoungAbstractEnvironmental variation can play an important role in ecological competition by influencing the relative advantage between competing species. Here, we consider such effects by extending a classical, competitive Moran model to incorporate an environment that fluctuates periodically in time. We adapt methods from work on these classical models to investigate the effects of the magnitude and frequency of environmental fluctuations on two important population statistics: the probability of fixation...
Source: Journal of Theoretical Biology - December 4, 2019 Category: Biology Source Type: research

Resident Attitudes Towards Caesarean Delivery in Canadian Obstetrics and Gynaecology Residency Programs.
CONCLUSION: Obstetrics and gynaecology residents in Canada have favourable attitudes towards interventions that support vaginal and assisted delivery. There was variability in observed attitudes across programs, although this was not statistically significant. PMID: 31787548 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - December 4, 2019 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Thermodynamic study of selected monoterpenes IV
Publication date: Available online 3 December 2019Source: The Journal of Chemical ThermodynamicsAuthor(s): Vojtěch Štejfa, Michal Fulem, Květoslav RůžičkaAbstractAn extensive thermodynamic study of three monoterpenes, (−)-menthone, (+)-pulegone, and (−)-isopulegol, is presented in this work. Phase behaviour was investigated by a heat-flux differential scanning calorimetry (DSC) from 183 K resulting in detection of polymorphic behaviour of (−)-isopulegol and a noticeably slow crystallization of (+)-pulegone. Two static apparatus were employed for the vapour pressure measurements over a wide tem...
Source: The Journal of Chemical Thermodynamics - December 4, 2019 Category: Chemistry Source Type: research

Microfluidic paper-based analytical device for convenient use in measurement of iodate in table salt and irrigation water
We report a convenient microfluidic paper-based analytical device (µPAD) for the determination of iodate. The µPAD was fabricated using an ink-stamp with a simple circle design. Colorimetric detection of iodate employs the oxidation of hydroxylamine by the iodate to generate nitrite which reacts with the Griess reagent producing an intense magenta color. The images were recorded by a digital camera, and converted to a green scale color intensity by ImageJ. Calibration of iodate was linear in the range of 50–400 mg L−1 with a detection limit of 38.1 mg L−1. With such a wide ...
Source: Microchemical Journal - December 4, 2019 Category: Chemistry Source Type: research

Phase and microstructural study of urinary stones
Publication date: January 2020Source: Microchemical Journal, Volume 152Author(s): Miljana Mirković, Anja Dosen, Suzana Erić, Predrag Vulić, Branko Matović, Aleksandra RosićAbstractIn this paper we present the phase and morphological characteristics of urinary stones from Serbian patients. The study included for the first time the determination of the phase composition and a statistical analysis of the presence of different types of urinary stones in both men and women in Serbia. The main goal of study was representation of collected data for the first time. For past three years, more than 600 samples were collected fr...
Source: Microchemical Journal - December 4, 2019 Category: Chemistry Source Type: research

Metabolomics analysis reveals the mechanisms of the effect of Sijunzi decoction on spleen deficiency syndrome in a rat model
This study revealed the mechanism of Sijunzi decoction for the treatment of spleen deficiency syndrome and provided a theoretical basis for the clinical application of Sijunzi decoction. (Source: Microchemical Journal)
Source: Microchemical Journal - December 4, 2019 Category: Chemistry Source Type: research

Human Navigational Strategy for Intercepting an Erratically Moving Target in Chase and Escape Interactions.
Authors: Tsutsui K, Shinya M, Kudo K Abstract Pursuit and interception of moving targets are fundamental skills of many animal species. Although previous studies in human interception behaviors have proposed several navigational strategies for intercepting a moving target, it is still unknown which navigational strategy humans use in chase-and-escape interactions. In the present experimental study, by using two one-on-one tasks as seen in ball sports, we showed that human interception behaviors were statistically consistent with a time-optimal model. Our results provide the insight about the navigational strategy f...
Source: Journal of Motor Behavior - December 4, 2019 Category: Neurology Tags: J Mot Behav Source Type: research

Frequency of iron deficiency anemia in pregnant and non-pregnant women suffering from restless legs syndrome.
This study also included a control group of 231 age-compatible non-pregnant women. Women who met the international criteria for diagnosing the syndrome filled in a sociodemographic questionnaire.Results. A statistically significant association between the existence of iron deficiency anemia and RLS in the sample of the examined women was proven (p 
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Disordered bone metabolism in hereditary spherocytosis patients.
Conclusion: Hereditary spherocytosis patients should be followed closely in terms of development, puberty, bone health as they are in other hemolytic anemias. Nutritional recommendations, vitamin D supplementation, physical activity should be advised to protect bone health. PMID: 31793406 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Multivariate logistic analysis of predictors of response to immunosuppressive therapy in children with aplastic anemia: a double-center study.
CONCLUSION: Duration of AA, ANC and decreased ALC rate after IST might predict the response to IST, among which the rate of decreased ALC after IST is the most important predictive factor. PMID: 31793407 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Associations of childhood adiposity and changes in adiposity status from childhood to adulthood with pregnancy hypertension
Conclusion(s)Childhood adiposity was associated with increased risk of pregnancy hypertension, with the association of childhood abdominal obesity independent of adult abdominal obesity. Women who were persistently overweight/obese or abdominally obese since childhood had the highest risk of pregnancy hypertension. (Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health)
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 4, 2019 Category: OBGYN Source Type: research

Music Therapy for Surgical Patients: Approach for Managing Pain and Anxiety
Music therapy (MT) in the inpatient setting has demonstrated positive outcomes worldwide. There was no protocol to utilize MT at this organization. The purpose of this project was to incorporate and evaluate MT as an adjunct intervention to address pain and anxiety in adult surgical step-down patients. Evidence-based practice change using the 8A's method integrated individualized MT provided by a board-certified music therapist to hospitalized patients over a 3-month period. Training was provided to 35 nurses and unit-assigned social worker on the utilization of MT for patients exhibiting pain or anxiety symptoms. The clin...
Source: Critical Care Nursing Quarterly - December 4, 2019 Category: Nursing Tags: Original Articles Source Type: research

Dexmedetomidine's Relationship to Delirium in Patients Undergoing Cardiac Surgery: A Systematic Review
This systematic review aims to determine the relationship between postoperative delirium and the use of dexmedetomidine in comparison with commonly used sedatives/analgesics in the postoperative cardiac surgery patient. A systematic literature search of PubMed plus, CINAHL, Scopus, and Ovid, and limited to the English language in the last 10 years, was performed. Randomized controlled trials, observational and retrospective studies, and meta-analyses with at least 1 delirium assessment tool were included. The search found 196 potential articles; however, only 12 met the criteria outlined. The systematic review revealed a d...
Source: Critical Care Nursing Quarterly - December 4, 2019 Category: Nursing Tags: Original Articles Source Type: research

A randomised controlled trial evaluating the effectiveness of Facebook compared to leaflets in raising awareness of melanoma and harmful sun-related behaviour among young adults
This study describes a randomised control trial investigating whether printed leaflets or social media are more effective in increasing knowledge of the risks of sun exposure and melanoma in people aged 18–29. The study participants were 18–29-year-old university students or graduates, recruited in London. A baseline level of knowledge was measured using the Skin Cancer and Sun Knowledge questionnaire. Study participants were then randomised into either a leaflet arm or Facebook arm. Identical information was delivered through a SunSafe campaign via either posted leaflets or Facebook during a 10-day exposure wi...
Source: European Journal of Cancer Prevention - December 4, 2019 Category: Cancer & Oncology Tags: Skin Cancer Source Type: research

Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians
Intake of heterocyclic amines (HCAs) and other mutagenic compounds formed during cooking has been hypothesized to be responsible for the positive association observed between red meat and colorectal cancer. We evaluated whether well-done/very well-done preferences for various meat and fish items, higher intakes of meat and fish, and meat-derived and fish-derived HCA are associated with the risk of colorectal adenoma (CRA) in a Japanese–Brazilian population. We selected 302 patients with adenoma and 403 control individuals who underwent total colonoscopy between 2007 and 2013, and collected information on aspects of m...
Source: European Journal of Cancer Prevention - December 4, 2019 Category: Cancer & Oncology Tags: Gastrointestinal Cancer Source Type: research

Effect of metformin on the risk of prostate cancer in patients with type 2 diabetes by considering different confounding factors: a meta-analysis of observational studies
Preclinical studies have suggested the antitumorigenic properties of metformin on prostate cancer; results from epidemiological studies remain contradictory. We aim to investigate the evidence of metformin and the risk of prostate cancer. PubMed, Embase, Cochrane Library, and Web of Science databases were searched for eligible studies. Meta-analyses were carried out using the most fully adjusted hazard ratios and the corresponding 95% confidence intervals. Eighteen cohort studies and six case–control studies representing 2 009 504 male patients with type 2 diabetes mellitus were identified. The pooled HR of prostate ...
Source: European Journal of Cancer Prevention - December 4, 2019 Category: Cancer & Oncology Tags: Prostate Cancer Source Type: research

The inner temperature of the olives (cv. Leccino) before processing affects the volatile profile and the composition of the oil
Publication date: Available online 2 December 2019Source: Food Research InternationalAuthor(s): Athanasia-Maria Dourou, Stefano Brizzolara, Gaia Meoni, Leonardo Tenori, Franco Famiani, Claudio Luchinat, Pietro TonuttiAbstractThe effects of pre-processing decreasing temperature (19, 15 and 10 °C) of olive fruit (cv. Leccino) harvested at three developmental stages (semi-ripe, ripe, advanced ripening) have been evaluated on oil in terms of basic quality parameters, composition, organoleptic traits, and aroma profiles. A total of 40 metabolites (volatiles and non-volatiles) were identified by 1H-NMR and GC/MS analyses. Mu...
Source: Food Research International - December 4, 2019 Category: Food Science Source Type: research

Targeted healthy compounds in small and large-scale brewed beers
Publication date: Available online 3 December 2019Source: Food ChemistryAuthor(s): T. Bertuzzi, A. Mulazzi, S. Rastelli, G. Donadini, F. Rossi, G. SpignoAbstractThe determination of targeted healthy compounds in the most popular small and large-scale brewed beer sold in Italy was carried out. Nitrogen compounds, fermentable sugars, total phenolic content and antioxidant capacity, β-glucans, pyridoxine, folates and silicon were quantified. Further, amine content was determined since raw materials and brewing technology can affect their level. Significantly higher values for total phenolic content, antioxidant activity,...
Source: Food Chemistry - December 4, 2019 Category: Food Science Source Type: research

GSE131379 Hypoxia effects on the transcriptome of HeLa cells
In this study, the transcriptome-wide response of human HeLa cervical cancer cells to hypoxia was investigated. The circRNA signatures as well as differential gene expression and alternative splicing were analyzed by integrating available tools with custom approaches for quantification and statistical analysis. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 4, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Retrospective survey of parasitism identified in feces of client-owned cats in North America from 2007 through 2018
Publication date: Available online 3 December 2019Source: Veterinary ParasitologyAuthor(s): Yoko Nagamori, Mark E. Payton, Emily Looper, Hadley Apple, Eileen M. JohnsonAbstractOwnership of domestic cats in North America has been on the increase; however, there are only a few surveys conducted on the prevalence of parasitism in client-owned cats over years. Our study objective was to evaluate parasite prevalence through statistical analysis of fecal examination results for client-owned cats on samples submitted to the veterinary parasitology diagnostic laboratory of Oklahoma State University over a 12-year period. All resul...
Source: Veterinary Parasitology - December 4, 2019 Category: Veterinary Research Source Type: research

Response statistics prediction for structures with uncertain attachments using a Krylov approach
Publication date: Available online 2 December 2019Source: Journal of Sound and VibrationAuthor(s): Shuo Li, Brian R. Mace, Jaspreet S. DhupiaAbstractThis paper presents an approach to calculate the response statistics of a structure comprising a main, host structure with an attachment whose coupling location is not exactly known. The proposed approach is based on a Krylov model order reduction method, which reduces the order of a finite element model of the structure enabling an efficient way to estimate the statistics of the structural response. The multi-point constraint method is used to connect the finite element model...
Source: Journal of Sound and Vibration - December 4, 2019 Category: Physics Source Type: research

Codon Use and Aversion is Largely Phylogenetically Conserved Across the Tree of Life
We examined each codon within each ortholog to determine the codon usage for each species. In total, 890 814 codons were parsimony informative. Next, we compared species that used a codon with species that did not use the codon. We assessed each codon's congruence with species relationships provided in the Open Tree of Life (OTL) and determined the statistical probability of observing these results by random chance. We determined that 25 771 codons had no parallelisms or reversals when mapped to the OTL. Codon usages from orthologous genes spanning many species were 1 109x more likely to be congruent with species relations...
Source: Molecular Phylogenetics and Evolution - December 4, 2019 Category: Molecular Biology Source Type: research

Methylone determination in oral fluid using microextraction by packed sorbent coupled to ion mobility spectrometry
Publication date: Available online 3 December 2019Source: Microchemical JournalAuthor(s): A. Sorribes-Soriano, S. Sánchez-Martínez, R. Arráez-González, F.A. Esteve-Turrillas, S. ArmentaAbstractA methodology based on microextraction by packed sorbent (MEPS) followed by ion mobility spectrometry (IMS) has been developed for the simple and automated determination of methylone in oral fluids. MEPS was carried out using a 100 µL eVol® XR hand-held automated analytical syringe filled with octadecyl silica sorbent. The effect of main experimental parameters of MEPS such as sample pH and ionic...
Source: Microchemical Journal - December 4, 2019 Category: Chemistry Source Type: research

An integrated strategy for rapid discovery and prediction of nucleobases, nucleosides and amino acids as quality markers in different flowering stages of Flos Chrysanthemi using UPLC–MS/MS and FT-NIR coupled with multivariate statistical analysis
Publication date: Available online 3 December 2019Source: Microchemical JournalAuthor(s): Xiangwei Chang, Dandan Wei, Shulan Su, Sheng Guo, Sien Qian, Hui Yan, Ming Zhao, Erxin Shang, Dawei Qian, Xiaodong Sun, Jin-ao DuanAbstractNucleobases, nucleosides, nucleotides and amino acids are important nutritional compounds, and some of them are positively correlated with the umami taste in scented tea. Taking these nutrients of Flos Chrysanthemi from three different flowering stages as the research object, an integrated strategy of ultra high-performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem...
Source: Microchemical Journal - December 4, 2019 Category: Chemistry Source Type: research

Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics
Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are c... (Source: BMC Medicine)
Source: BMC Medicine - December 4, 2019 Category: Internal Medicine Authors: Ping Zeng, Ting Wang, Junnian Zheng and Xiang Zhou Tags: Research article Source Type: research

Use of ecological momentary assessment to detect variability in mood, sleep and stress in bipolar disorder
Our aim was to study within-person variability in mood, cognition, energy, and impulsivity measured in an Ecological Momentary Assessment paradigm in bipolar disorder by using modern statistical techniques. Ex... (Source: BMC Research Notes)
Source: BMC Research Notes - December 4, 2019 Category: Research Authors: Han Li, Dahlia Mukherjee, Venkatesh Basappa Krishnamurthy, Caitlin Millett, Kelly A. Ryan, Lijun Zhang, Erika F. H. Saunders and Ming Wang Tags: Research note Source Type: research

Does self-rated health status influence receipt of an annual flu vaccination?
Publication date: Available online 2 December 2019Source: Preventive MedicineAuthor(s): Ian Watson, S. Cristina OanceaAbstractDespite 79,400 deaths due to the influenza (flu) virus during the 2017–18 season,
Source: Preventive Medicine - December 4, 2019 Category: International Medicine & Public Health Source Type: research

Disease burden of echinococcosis in Tibetan communities-a significant public health issue in an underdeveloped region of western China.
Abstract Echinococcosis is considered by the World Health Organization (WHO) to be a neglected zoonotic disease in the world. Some Tibetan communities were found to be highly endemic for echinococcosis just 20 years ago. Until recently, we were able to understand the overall disease burden of echinococcosis in Tibetan communities after prevalence data being available from nationwide investigations from 2012 to 2016. Data were abstracted from 9 publications regarding to echinococcosis prevalence between 2016-2018; from 10 data bases on echinococcosis prevalence for 151 Tibetan counties; and statistics of population...
Source: Acta Tropica - December 4, 2019 Category: Infectious Diseases Authors: Wang Q, Yang L, Wang Y, Zhang GJ, Zhong B, Wu WP, Zheng CJ, Liao S, Yu WJ, He W, Wang Q, Chen F, Li RR, Huang Y, Yao R, Zhou XN Tags: Acta Trop Source Type: research

Linking childhood emotional abuse and adult depressive symptoms: The role of mentalizing incapacity.
CONCLUSIONS: This study provided preliminary evidence for hypermentalizing and hypomentalizing as mechanisms whereby early emotional abuse can lead to later depression. A normal to high level of mentalizing capacity might serve as a protective factor to suspend the pathway from childhood maltreatment to subsequent depression and become a promising target in psychological treatments. As cross-sectional data does not allow conclusions to be drawn on causal relationships, longitudinal data in a more representative sample is needed to capture relevant context and further examine our findings. PMID: 31812024 [PubMed - as s...
Source: Child Abuse and Neglect - December 4, 2019 Category: Child Development Authors: Li ET, Carracher E, Bird T Tags: Child Abuse Negl Source Type: research

Cardioinformatics: the nexus of bioinformatics and precision cardiology.
Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17 million deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, most bioinformatics and computational biology research and funding to date has been concentrated predominantly on cancer research, with a relatively modest footprint in CVD. In this paper, we review the existing literary landscape and critically assess the unmet need to further develop an emerging field at the multidisciplinary interface of bioinformatics and precision cardiovascular medicine, which we refer to as 'c...
Source: Briefings in Bioinformatics - December 4, 2019 Category: Bioinformatics Authors: Khomtchouk BB, Tran DT, Vand KA, Might M, Gozani O, Assimes TL Tags: Brief Bioinform Source Type: research