Brain slice viability determined under normoxic and oxidative stress conditions: involvement of slice quantity in the medium.
Conclusion: These results show that when using brain slices method for investigating the structural and functional features of brain at the molecular and cellular levels, both slice quantity in the medium and incubation volume should be considered first. Increasing slice quantity or decreasing incubation volume probably causes an increase in the concentration of endogenous substance(s) involved in neuroprotection. PMID: 32065058 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 19, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis.
Conclusion: The reductions in vessel density of the retinal or peripapillary area of patients with RRMS shown in this study should be investigated further to determine whether it is a secondary lesion to optic neuritis (ON) or a primary vasculopathic condition of MS. PMID: 32048550 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between exposure to hot/cold weather and the clinical features of headaches in patients with migraine and tension-type headaches.
Conclusions: In obese patients with tension-type headache, it was found that hot weather triggered headache more than cold weather. In patients with migraine and tension-type headaches, no relationship was found between exposure to hot/cold weather as a trigger and the clinical features of headaches. The accurate identification of the factors precipitating headaches by both clinicians and patients can help lower the frequency of headaches. PMID: 32048556 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Flexors activity of affected upper extremity in stroke patients during different standing conditions and their relationships with clinical scales: a cross-sectional study.
Authors: Wang S, Chen X, Zhuang R, Yang Z, Jiang W, Wang T Abstract Purpose: To explore the flexors activity of affected upper extremity in stroke patients during different standing conditions and their relationships with clinical scales.Materials and methods: Sixteen stroke patientswere recruited, all subjects stood on balance equipment with four different standing postures. The electromyogram (EMG) simultaneously recorded the muscle activity of bilateral biceps brachii, triceps brachii, flexor carpi radialis and extensor carpi radialis and their integrated electromyogram were figured out the contraction rate of e...
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The effect of intravenous ginkgolide on clinical improvement of patients with acute ischemic stroke.
Authors: Dong Y, Li H, Dong Q Abstract Aims: To compare the efficacy of ginkgolide in the treatment of Chinese patients with ischemic stroke between pre-marketing and post-marketing studies.Methods: This is a re-analysis of a pre-marketing (phase II/III, multicenter, double-blind, parallel-controlled; February 2005 to September 2005) and post-marketing (phase IV, multicenter, open, single-arm registration; April 2013 to June 2014) studies. The intervention groups received intravenous ginkgolide (10 mL daily, 14 days). Primary outcome was an improvement of National Institute of Health Stroke Scale (NIHSS) and modifi...
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Reduced expression of L-selectin in T-cells correlates with relative lymphocyte increase in patients with RRMS treated with natalizumab - functional implication towards PML risk.
Authors: Boziki MK, Karapanayotides T, Papadopoulos G, Lagoudaki R, Melo P, Bakirtzis C, Nikolaidis I, Gounari E, Tsavdaridou V, Skoura L, Afrantou T, Tatsi T, Grigoriadou E, Polyzoidou E, Mandoras N, Giantzi V, Kalogera-Fountzila A, Ioannidis P, Parissis D, Pelidou SH, Zoidou S, Grigoriadis N Abstract Objectives: Natalizumab (NTZ), a treatment indicated for patients with highly active Relapsing - Remitting Multiple Sclerosis (RRMS), is known to induce increased relative frequency of lymphocytes. Progressive Multifocal Leukoencephalitis (PML) is a rare but serious adverse event related to NTZ. Moreover, r...
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Long-term aneurysm recurrence and de novo aneurysm formation after surgical treatment of unruptured intracranial aneurysms: a cohort study and systematic review.
Discussion: Despite some discrepancy regarding the incidence, both cohorts show a non-negligible long-term risk of aneurysm recurrence and de novo aneurysm formation, which warrants life-long imaging follow-up.Abbreviations: SD: standard deviation; DSA: digital subtraction angiography; CTA: computed tomography angiography; MRA: magnetic resonance angiography; MCA: middle cerebral artery; ACA: anterior cerebral artery; ACommA: anterior communicating artery; ICA: internal carotid artery; ADPKD: autosomal dominant polycystic kidney disease; MeSH: Medical Subject Headings. PMID: 32048571 [PubMed - as supplied by publisher]...
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Use of high-sensitivity digital ELISA improves the diagnostic performance of circulating brain-specific proteins for detection of traumatic brain injury during triage.
Conclusions: The use of digital ELISA over conventional ELISA methods improves the diagnostic performance of circulating brain-specific proteins for detection of TBI during triage. PMID: 32048573 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Anger and impulsiveness in migraine patients with and without aura.
Authors: Tanik N, Akturk T, Saçmaci H, Inan LE Abstract Background and purpose: Migraine is a common primary headache disorder triggered by internal or external stimuli. Impulsitivity and anger are associated with many neurological and psychiatric disorders. The aim of this study was to investigate the anger and impulsivity in migraine patients with or without aura.Methods: A total of 55 patients aged between 18 and 55, who were diagnosed with episodic migraine (31 with aura and 24 without aura) and 40 healthy controls were enrolled in this prospective cross-sectional study.Migraine diagnosis and classificat...
Source: Neurological Research - February 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Low density lipoprotein cholesterol values and outcome of stroke patients: influence of previous aspirin therapy.
Authors: Freitas-Silva M, Medeiros R, Nunes JPL Abstract Background: The link between low-density lipoprotein cholesterol (LDL-C) and stroke risk remains controversial and few studies have evaluated the effect of LDL-C after stroke survival.Aims: We assessed the hypothesis proposing the effect of LDL-C on the outcome of stroke patients under the influence of previous Aspirin Therapy.Methods: Associations between LDL-C and outcomes. The effect of LDL cholesterol on stoke outcome was evaluated using Kaplan-Meier methodology, log-rank test, Cox proportional hazard models and Bootstrap Analysis.Results: In a cohort of ...
Source: Neurological Research - February 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties.
Conclusion: These findings provided evidence for the cancer-promoting effect of miR-188-3p in GBM cells and demonstrated that GPR26 was directly targeted by miR-188-3p, which might contribute to the therapeutic therapy of GBM. PMID: 32024457 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by trans-resveratrol against collagenase-induced neurological and neurobehavioural deficits in rats involves adenosine A1 receptors.
This study aimed to investigate the involvement of the adenosine A1 receptor (A1R) in trans-resveratrol-induced neuroprotection in rats with collagenase-induced ICH.Methods: Sixty male Sprague-Dawley rats weighing 330-380 g were randomly divided into five groups (n = 12): (i) control, (ii) sham-operated rats, (iii) ICH rats pretreated with vehicle (0.1% DMSO saline, i.c.v.), (iv) ICH rats pretreated with trans-resveratrol (0.9 µg, i.c.v.) and (v) ICH rats pretreated with trans-resveratrol (0.9 µg) and the A1R antagonist, DPCPX (2.5 µg, i.c.v.). Thirty minutes after pretreatment, ICH was induced by intrast...
Source: Neurological Research - February 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Cognitive impairment profile differences in patients with psychogenic non-epileptic seizures and epilepsy patients with generalized seizures.
Conclusion: These findings suggest that the epilepsy group showed reduced cognitive scores even though they did not suffer from frequent seizures and were not drug-resistant. PMID: 31971099 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

New MRI lesions and topography at 6 months of treatment initiation and disease activity during follow up in relapsing remitting multiple sclerosis patients.
Conclusion: New lesions at the reference MRI in terms of number and topography increase the risk of radiological disease activity during the follow up. PMID: 31959078 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 23, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Lower limb muscle magnetic resonance imaging in Chinese patients with myotonic dystrophy type 1.
Conclusion: Here, we found fatty infiltration present in most Chinese DM1 patients with a selective involvement pattern. There is a correlation between the total mean score of fatty infiltration and MIRS grading, age and disease duration. PMID: 31951783 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 19, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Comparison of seizure outcomes and safety between anterior temporal lobotomy and lobectomy in patients with temporal lobe epilepsy.
Discussion: ATLo is not inferior to ATLe for patients with drug-resistant temporal epilepsy. There was no significant difference in seizure outcomes or the rate of postoperative complications between the two groups. A large sample randomized control study is needed. PMID: 31939712 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 17, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Effect of NMDAR-NMNAT1/2 pathway on neuronal cell damage and cognitive impairment of sevoflurane-induced aged rats.
Conclusion: Activation of NMDAR-NMNAT1/2 signaling pathway could not only reduce neuronal apoptosis, but also alleviate sevoflurane-induced neuronal inflammation and cognitive impairment in aged rats. PMID: 31941414 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 17, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Increasing trimethylamine N-oxide levels as a predictor of early neurological deterioration in patients with acute ischemic stroke.
In this study, we aimed to investigate whether serum TMAO levels could predict early neurological deterioration (END) after acute ischemic stroke.Methods: We prospectively recruited patients with first-ever ischemic stroke and hospitalized within 24 h of symptoms onset during Mar 2018 to Mar 2019. Plasma TMAO levels were quantified using stable isotope dilution high-performance liquid chromatography with tandem mass spectrometry after admission. END was defined as an increase in the total National Institutes of Health Stroke Scale by 2 or more points within 3 days.Results: Of the 362 patients included, END was diagnosed in...
Source: Neurological Research - January 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Differences in nerve excitability properties between isolated bulbar palsy and bulbar-dominant amyotrophic lateral sclerosis.
This study aimed to identify differences in the excitability properties between them.Methods: We consecutively collected data on 22 ALS patients: 13 with cALS, 5 with PBP, and 4 with IBP. An automated nerve excitability test (NET) was applied to measure the strength-duration time constant, threshold electrotonus (TE), current-threshold relationship, and recovery cycle. The axonal excitability properties were compared between the ALS groups and 25 controls.Results: Compared to controls, the cALS group showed a greater change in the depolarizing phase of TE of 90-100 ms after depolarizing current [TEd(90-100)] (53.3±1...
Source: Neurological Research - January 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Neuroimaging findings in patients with idiopathic intracranial hypertension and cerebral venous thrombosis, and their association with clinical features.
Conclusion: Neuroimaging findings are useful tools with high diagnostic sensitivity in IIH. The most sensitive finding was increased peri-optic CSF. The utility of these neuroimaging correlates and their potential significance as solely diagnostic markers in IIH should be investigated in future large-scale studies. PMID: 31910744 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 10, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Sub-chronic oral cinnamaldehyde treatment prevents scopolamine-induced memory retrieval deficit and hippocampal Akt and MAPK dysregulation in male mice.
Discussion: The results of the present study revealed that oral sub-chronic cinnamaldehyde administration has the capability to prevent memory retrieval deficit induced by cholinergic blockade and restores hippocampal MAPK and Akt dysregulations. PMID: 31910792 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 10, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Cognitive functions in pediatric multiple sclerosis: 2-years follow-up.
Conclusion: Pediatric MS is likely to affect patients' cognition concurrently with their disability levels. This effect is significant in the non-verbal reasoning area in patients with disease onset before age 12 years. A practical method assessing this function should be part of these patients' regular follow-up for optimal treatment, prevention and rehabilitation. PMID: 31913090 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 10, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The effect of Lipopolysaccharide (LPS) pretreatment on hippocampal apoptosis in traumatic rats.
Authors: Eslami M, Alizadeh L, Morteza-Zadeh P, Sayyah M Abstract Objectives: Traumatic brain injury (TBI) is a serious medical problem that affects the quality of life. Apoptosis is a form of programmed cell death that happens after trauma. Effector caspases are responsible for initiating apoptosis.Methods: In the present study, we examined the effect of LPS preconditioning (0.1 and 0.5 mg/kg, ip; 5 days prior controlled cortical injury) on apoptosis, 4 and 12 hours after trauma. We investigated possible mechanisms on the expression of caspase3 and caspase7 in hippocampal CA1 and CA3 areas by using immun...
Source: Neurological Research - January 10, 2020 Category: Neurology Tags: Neurol Res Source Type: research

An analysis of the risk of perioperative ischemic stroke in patients undergoing non-cardiovascular and non-neurological surgeries.
Conclusions: History of stroke and smoking, renal insufficiency, and low HDL-C are independent risk factors for PIS. It is feasible to assess the risk of stroke in preoperative patients using PCE in clinical practice. PMID: 31903867 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 7, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Knockdown of lncRNA SNHG1 alleviates oxygen-glucose deprivation/reperfusion-induced cell death by serving as a ceRNA for miR-424 in SH-SY5Y cells.
Conclusion: Taken together, this research supported the first evidence that lncRNA SNHG1 regulates OGD/R-induced cell death through serving as a ceRNA for miR-424 in SH-SY5Y cells. PMID: 31900069 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

AnvirzelTMregulates cell death through inhibiting GSK-3 activity in human U87 glioma cells.
Authors: Terzioglu-Usak S, Nalli A, Elibol B, Ozek E, Hatiboglu MA Abstract Objectives: Cardiac glycosides are used as potential anti-cancer agents due to their effects on the inhibition of proliferation and induction of apoptosis and/or autophagy in cancer cells. Herein, we aimed to study the potential signaling pathways taken role in differential cell-death properties of AnvirzelTM which is consisted of two toxic cardiac glycosides (oleandrin and oleandrigenin), in U87 human glioblastoma cells.Methods: The anti-proliferative and anti-migratory effects of AnvirzelTM were assessed in U87 cells by WST-1 assay and wo...
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Small damage of brain parenchyma reliably triggers spreading depolarization.
Discussion: The findings indicate that SD may represent a previously unidentified side effect of local parenchymal injury during site-specific microinjections and stereotactic surgery. PMID: 31900075 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Inflammatory biomarkers and risk of ischemic stroke and subtypes: A 2-sample Mendelian randomization study.
Conclusions: Our study did not find convincing evidence to support that inflammatory biomarkers like IL-1Ra, sIL-6R and CRP are causally associated with the risk of ischemic stroke or its subtypes. PMID: 31900081 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Correlation between risk factors of cerebrovascular disease and calcified plaque characteristics in patients with atherosclerotic severe carotid stenosis.
Authors: Xu X, Hua Y, Wang L, Hou W, Xia M Abstract Objectives: The aim of this study was to evaluate the relationship between the risk factors of cerebral vascular diseases (CVD) and the characteristics of calcified plaques in patients with severe carotid arteriosclerosis stenosis (SCAS).Methods: A total of 402 patients with SCAS who were treated in our hospital between January to December 2016 were included in this study. The patients were divided into calcified plaque group and non-calcified plaque group according to the ultrasonography and computerized tomography angiography (CTA) or digital subtraction angiogr...
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Correlations between the monocyte to high-density lipoprotein cholesterol ratio and white matter hyperintensities in migraine.
This study aimed to establish whether there is a relationship between the Monocyte to High-Density Lipoprotein Cholesterol (HDL-C) ratio (MHR) white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI), and whether it can be used as a new marker for predicting disability and severity of attack.Materials and methods: This case-control study included 201 migraine patients (114 without WMHs and 87 with WMHs) and 150 healthy control subjects. Intensity of pain was determined by Visual Analogue Scale (VAS) and disability rates were determined by Migraine Disability Assessment Scale (MIDAS). Blood samples were take...
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Resting-state fMRI reveals increased functional connectivity in the cerebellum but decreased functional connectivity of the caudate nucleus in Parkinson's disease.
Discussion: We found increased functional connectivity among cerebellar structures in PD, which may reflect an adaptive (compensatory) mechanism through activation of additional brain structures to restore gait function. In contrast, a relative disconnection between the precuneus and caudate nucleus in PD patients might indicate an impaired brain network unrelated to the risk of falls. Cerebellar areas might thus be considered as future therapeutic targets for neuromodulatory treatment of postural instability in PD.Abbreviations: DMN: default mode network; FC: functional connectivity; IPL: inferior parietal lobule; MMSE: M...
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis by up-regulated PUMA under hypoxia condition.
Conclusions: the present study revealed that GAS5 aggravated cell apoptosis in hypoxia condition via miR-221/PUMA axis, which may provide potential targets for the treatment of stroke. PMID: 31878844 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 28, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Effect of tadalafil and nitric oxide agonist sodium nitroprusside on penicillin-induced epileptiform activity.
Conclusion: Data from the present study indicate that tadalafil hasan anticonvulsion effect against penicillin-induced epileptiform activity in rats. PMID: 31847728 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 20, 2019 Category: Neurology Tags: Neurol Res Source Type: research

DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-κB signaling and might therefore serve as a potential therapeutic target for SCI. PMID: 31813339 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 11, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.
Conclusion: These findings indicate the neuroprotective effects of HCH on DEACMP, which are related to the activation of Nrf2 signaling pathway. PMID: 31679470 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 6, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Does the nutritional status of acute stroke patients affect the neurological status in the early post-stroke period?
Authors: Wierzbicki K, Horyniecki M, Mamak D, Szopa M, Buchała J, Stawarz G, Florek S, Adamczyk-Sowa M Abstract According to recent reports, malnutrition may be associated with a worse prognosis in stroke patients. The aim of this study was to determine the nutritional status of stroke patients and its impact on neurological and functional status of patients in the early post-stroke period. Our prospective study included a total of 128 patients admitted to the Stroke Unit. The assessment was made in the patients within the first week after the onset of stroke symptoms. Groups of patients with abnormal body mass in...
Source: Neurological Research - November 6, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sj ögren's syndrome.
Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren's syndrome. Neurol Res. 2019 Oct 29;:1-5 Authors: Yasemin E, Neşe Güngör Y, Özişler C Abstract Objectives: Polyneuropathy is the most common neurological complication in primary Sjögren's syndrome (pSS). A ratio of sural nerve and superficial radial nerve sensorial action potential amplitudes (SRARs) of
Source: Neurological Research - October 31, 2019 Category: Neurology Tags: Neurol Res Source Type: research

A multicenter retrospective research of anterior debridement, decompression, bone grafting, and instrumentation for cervical tuberculosis.
Authors: Yang S, Wang D, Xu J, Luo F, Wu W, Zhang Z Abstract Objective: To observe the clinical effect of anterior debridement, decompression, bone grafting, and instrumentation for cervical spinal tuberculosis in four hospitals. Materials and Methods: This research retrospectively analyzed 146 patients with cervical spinal tuberculosis who were treated by anterior debridement, decompression, bone grafting, and instrumentation in four institutions between January 2000 and January 2015. There were 68 males and 78 females with an average age of 31.32 ± 11.69 years. All patients received chemotherapy for 18 mon...
Source: Neurological Research - October 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Neuro-endoscopic management of hemorrhagic moyamoya disease in the acute stage: single institute experience.
Conclusion: Neuro-endoscopic hematoma removal may be the optimal management method for hemorrhagic MMD in the acute stage in terms of the maximum preservation of pre-existing collateral anastomosis without affecting the potential donor vessels used for future revascularization surgery. Abbreviations: MMD: Moyamoya disease; STA: Superficial temporal artery; MCA: Middle cerebral artery; JAM: Japan Adult Moyamoya; ICH: Intracerebral hemorrhage; IVH: Intraventricular hemorrhage; SAH: Subarachnoid hemorrhage; CT: Computed tomography; TE: Total evacuation; PE: Partial evacuation; SMR: Light mass reduction; MR: Magnetic resonance...
Source: Neurological Research - October 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Regulatory role of hippocampal PI3K and mTOR signaling pathway in NMDA-induced infant spasm rats.
Authors: Yang G, Wang J, Wan L, Shi XY, Meng Y, Ren WH, Zou LP Abstract Objectives: To explore the role of mTOR signaling pathway in modulating epileptogenesis in an N-methyl-D-aspartic acid (NMDA)-induced infant spasm (IS) rat model. Methods: After inducing IS successfully, the phosphorylation status of PI3K, Akt, mTOR and S6K of brain and hippocampus tissues was assessed using western blot and immunochemistry analysis, respectively. The possible mechanism of mTOR signaling pathway was evaluated by the, inhibitors for mTOR and PI3K, rapamycin and wortmannin, respectively. The inhibitors were injected into the intr...
Source: Neurological Research - October 10, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice.
Discussion: These results showed that the absence of gut microbiota could influence host behaviors and lipid metabolism. Our findings could provide original and valuable data for future studies to further investigate the microbiota-gut-brain axis. PMID: 31587617 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 8, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people.
Discussion: Yoga-plus improved cognitive, affective, ADL, and physical functions in a local elderly population, particularly among below-baseline individuals, indicating the benefits of dementia prevention among elderly individuals. PMID: 31588880 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 8, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Noncontrast computed tomography markers of outcome in intracerebral hemorrhage patients.
Authors: Quintas-Neves M, Marques L, Silva L, Amorim JM, Ferreira C, Pinho J Abstract Objectives: The characterization of markers capable of predicting clinically significant hematoma growth (HG) in patients with intracerebral hemorrhage (ICH) may be useful for the selection of patients for clinical trials. The use of several noncontrast computed tomography (NCCT) markers has been suggested to stratify the risk of HG. The aim of this study was to analyze HG prediction using different NCCT markers in patients with spontaneous ICH. Methods: Single-hospital retrospective study of patients with spontaneous ICH, who underwent initial NCCT
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice.
Conclusion: These results suggest that NBP ameliorates cognitive deficits induced by type 2 diabetes mellitus through improving CaMKII-mediated LTP and cell ultrastructure in the hippocampus. NBP is a potential therapeutic agent for diabetes-associated cognitive deficits. Abbreviations: NBP: DL-3-n-butylphthalide; LTP: long-term potentiation; CaMKII: calcium/calmodulin-dependent protein kinase II; NR2B: N-methyl-D-aspartic acid receptor subtype 2B; GluR1: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subtype 1. PMID: 31578943 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Thrombolysis with rhPro-UK 3 to 6 hours after embolic stroke in rat.
Conclusions: RhPro-UK had an obvious therapeutic effect on ischemic stroke caused by thrombosis, and could be started within 4.5 h TTW with less side effects of cerebral hemorrhage than that of UK. PMID: 31584350 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study.
Conclusions: Our study showed genetic variants of CRP-related genes were associated with risk of ischemic stroke. Our findings could provide useful data for the etiology of ischemic stroke. PMID: 31584351 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Intrathecal injection of dexmedetomidine ameliorates chronic neuropathic pain via the modulation of MPK3/ERK1/2 in a mouse model of chronic neuropathic pain.
Conclusion: We confirmed that DEX exerts the analgesic effect on chronic neuropathic pain via the regulation of MKP3/ERK1/2 signaling pathway, which may contribute to clarification of the molecular mechanism and novel therapy for chronic neuropathic pain. PMID: 31584354 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Identification of two novel compound heterozygous CLCN1 mutations associated with autosomal recessive myotonia congenita.
Conclusions: Molecular genetics analysis offers an accurate method for diagnosing MC. Our results expand the mutational spectrum of recessive MC. PMID: 31566103 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 2, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Effects of the application of general anesthesia with propofol during the early stage of pregnancy on brain development and function of SD rat offspring and the intervention of DHA.
Conclusions: Application of general anesthesia with propofol during the early stage of pregnancy can negatively affect the brain development of the offspring to reduce the learning and memory ability, while DHA can reverse it. PMID: 31573411 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 2, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Effects of a new magnesium-rich artificial cerebrospinal fluid on contractile 5-hydroxytryptamine and endothelin receptors in rat cerebral arteries.
Conclusion Haemorrhagic CSF induces upregulation of 5-HT1B, ETB and ETA receptors in rat cerebral arteries. However, MACSF can maintain in-vitro rat basilar arteries in good physiological activity and normal expression of contractile 5-HT and ET receptors. PMID: 31559927 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 30, 2019 Category: Neurology Tags: Neurol Res Source Type: research