Thymoquinone protects DRG neurons from axotomy-induced cell death.
CONCLUSION: TQ exhibits a regenerative potential for the treatment of damaged peripheral nerves. PMID: 30088803 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 11, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Effect of swimming training on nerve morphological recovery after compressive injury.
This study aims to investigate morphological alterations caused by partial sciatic nerve ligation (PNL) and the efficacy of a moderate-intensity swimming training as therapeutic strategy for nerve regeneration. METHODS: A number of 30 male adult mice were equally divided in control, 14 days after PNL (PNL 14 days), 42 days after PNL (PNL 42 days), 70 days after PNL (PNL 70 days) and 5-week exercise training after 7 days post-lesion (PNL trained 35 days) groups. PNL trained 35 days group began with a 10-min session for 3 days and this time was gradually increased by 10&n...
Source: Neurological Research - August 11, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Activation of TRPV1 receptors affects memory function and hippocampal TRPV1 and CREB mRNA expression in a rat model of biliary cirrhosis.
This study set out to determine whether activation of transient receptor potential vanilloid type 1 (TRPV1) in the CA1 area of the hippocampus in rats improve memory impairment induced by biliary cirrhosis. METHODS: To assess learning and memory, passive avoidance task was carried out using a shuttle box. The mRNA expression of TRPV1 and cAMP response element binding (CREB) protein in the hippocampus were also evaluated by qT-PCR. RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocam...
Source: Neurological Research - August 8, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Identification of key target genes and biological pathways in multiple sclerosis brains using microarray data obtained from the Gene Expression Omnibus database.
CONCLUSION: Several key target genes and their GO and KEGG pathway enrichment identified in the present study may serve as feasible targets for MS therapies. PMID: 30074468 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 5, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Preoperative neutrophil-lymphocyte ratio correlated with glioma grading and glioblastoma survival.
This study aimed to investigate the relationship between preoperative NLR and glioma grading and also the correlation between NLR and glioblastoma survival. METHODS: The preoperative NLR was analyzed retrospectively in 239 gliomas of different grades, and receiver operating characteristic (ROC) curve analysis was adopted to investigate the prediction of glioma grading. Univariate and multivariate analyses were performed to analyze the variables of overall survival (OS) of glioblastoma patients. RESULTS: There were significant differences in the preoperative NLR values among the four glioma groups, with the highest ...
Source: Neurological Research - August 5, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The effect of dexmedetomidine on inflammatory inhibition and microglial polarization in BV-2 cells.
Authors: Sun Z, Lin Y, Li Y, Ren T, Du G, Wang J, Jin X, Yang LC Abstract OBJECTIVE: Microglia have different phenotypic and functional states: M1 is associated with inflammatory responses, whereas M2 results in anti-inflammatory effects. The cellular state of microglia plays an important role in brain inflammation associating with many neuroinflammatory diseases. The purpose of this study was to detect the effect of dexmedetomidine (Dex) on inflammatory inhibition and microglial polarization in BV-2 cells. MATERIALS AND METHODS: Dex exerts anti-inflammatory effects in various experimental models. The BV-2 micr...
Source: Neurological Research - August 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Benign paroxysmal positional vertigo in spontaneous intracranial hypotension.
CONCLUSION: BPPV is common in SIH patients. SIH patients with low CSF pressure may be prone to develop BPPV. PMID: 30052143 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 30, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Argatroban plus aspirin versus aspirin in acute ischemic stroke.
Authors: Chen L, Cao S, Yang J Abstract OBJECTIVES: Anticoagulant therapy in the acute phase of AIS remains controversial. The aim of this study was to investigate whether argatroban benefited early stroke outcomes compared with antiplatelet treatment. METHODS: We reviewed data from 1,485 patients with AIS hospitalized at Tianjin Union Medical Center (TUMC) between 1 January 2013 and 31 December 2015 from the TUMC registry database. Patients were divided into two groups: an antiplatelet group (aspirin 300 mg daily) and an argatroban group (argatroban 60 mg for 2 days followed by 20 mg daily;...
Source: Neurological Research - July 30, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Heart rate variability after endovascular coiling is associated with short-term outcomes in patients with subarachnoid hemorrhage.
Authors: Cai K, Ni Y, Zhang Y, Shen L, Ji Q, Cao M Abstract OBJECTIVE: to evaluate whether postoperative heart rate variability (HRV) predicts short-term outcomes in patients undergoing coil embolization of ruptured aneurysms. METHODS: Consecutive patients receiving endovascular coiling to treat aneurysmal subarachnoid hemorrhage (SAH) were retrospectively reviewed between November 2011 and December 2014 in the authors' institution. Heart rate (HR) and blood pressure (BP) recorded in the initial 24 h after endovascular treatment were extracted along with other clinical data. HR variability (HRV) and BP var...
Source: Neurological Research - July 28, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effect of lovastatin through down-regulation of pro-apoptotic Mst1 gene expression in rat model pilocarpine epilepsy.
CONCLUSION: Overall, the results of this study showed that lovastatin attenuates hippocampal cell death in Pilocarpine-induced status epilepticus rat model through downregulation of the pro-apoptotic Mst1 gene. ABBREVIATIONS: Mst1: Mammalian sterile 20-like kinase 1; Nrf2: nuclear factor erythroid 2-related factor 2; Bcl-2: B-cell lymphoma 2; HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A; RT-PCR: reverse transcription-polymerase chain reaction; TLE: Temporal Lobe Epilepsy; SE: status epilepticus. PMID: 30048231 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 28, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association of circulating blood HMGB1 levels with ischemic stroke: a systematic review and meta-analysis.
Authors: Le K, Mo S, Lu X, Idriss Ali A, Yu D, Guo Y Abstract OBJECTIVES: Inflammation plays a key role in the pathogenesis and progression of ischemic stroke (IS). The high mobility group box 1 (HMGB1) nucleoprotein is involved in the amplification of inflammatory responses during acute ischemic injury. HMGB1 levels in patients with active disease are higher than those in healthy controls. We performed a meta-analysis to assess currently published data pertaining to circulating blood HMGB1 levels in IS and the relationship with stroke severity. METHODS: We systematically searched for studies investigating the ...
Source: Neurological Research - July 19, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Involvement of prelimbic 5-HT7 receptors in the regulation of anxiety-like behaviors in hemiparkinsonian rats.
DISCUSSION: 5-HT7 receptors in the PrL are involved in the regulation of anxiety-like behaviors, which is attributable to changes in dopamine, 5-HT and NA levels in the limbic and limbic-related brain regions after activation and blockade of 5-HT7 receptors. ABBREVIATIONS: 6-OHDA: 6-hydroxydopamine; DMSO: dimethyl sulfoxide; DA: dopamine; EPM: elevated plus maze; MFB: medial forebrain bundlem; PFC: medial prefrontal cortex; NA: noradrenaline; PD: Pakinson's disease; PrL: prelimbic; 5-HT: serotonin; vHip: ventral hippocampus. PMID: 29989483 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 12, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Freezing of gait in Parkinson's disease: functional neuroimaging studies of the frontal lobe.
CONCLUSIONS: Our study revealed greater hypometabolism in FDG PET studies, predominantly in right-sided-specific motor regions of the frontal lobe in FOG patients and greater frontal disfunction in neuropsychological tests in PD patients with FOG. These data suggest that FOG may be related to functional impairment of the circuits connecting the frontal lobe and the basal ganglia. PMID: 29985119 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 10, 2018 Category: Neurology Tags: Neurol Res Source Type: research

MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
CONCLUSION: MiR-125b exerts protective effects on CIR injury through inhibition of Bax/Cytochrome C/Caspase-3signaling pathway via targeting p53, which is likely to be a promising treatment for CIR. ABBREVIATIONS: 3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween. TTC staining: Triphenyl tetrazolinm chloride staining; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. PMID: 29956588 [PubMed - as supplied by publishe...
Source: Neurological Research - June 30, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Investigation of subdural electrode displacement in invasive epilepsy surgery workup using neuronavigation and intraoperative MRI.
CONCLUSION: Comparison of pre-explantation and post-implantation iopMRI scans with CT/MRI data using the volume-rendering technique resulted in an accurate placement of electrodes. In one patient with a considerable electrode dislocation, the surgical approach and extent was changed due to the detected electrode shift. ABBREVIATIONS: ECoG: electrocorticography; EZ: epileptogenic zone; iEEG: invasive EEG; iopMRI: intraoperative MRI; MEG: magnetoencephalography; PET: positron emission tomography; SPECT: single photon emission computed tomography; 3D: three-dimensional. PMID: 29916770 [PubMed - as supplied by publishe...
Source: Neurological Research - June 20, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Neurological impairments in hypoxic neonates and lactate levels.
Authors: Jovandaric MZ, Milenkovic SJ Abstract INTRODUCTION: Metabolic acidosis with increasing lactate concentration develops due to the lack of oxygen in the tissues. OBJECTIVES: The effect of lactic acidosis on neurological development in the first year of life. MATERIALS AND METHODS: Our study included 50 newborns with perinatal hypoxia requiring oxygen therapy and 50 healthy newborns. pH, pCO2, pO2, base excess (BE) and lactates from arterialized capillary blood were determined in both groups of newborns, in the first and second hours after birth, and neurological development in the first year of life ...
Source: Neurological Research - June 19, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Silencing of LncRNA BDNF-AS attenuates A β25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress.
CONCLUSION: Silencing BDNF-AS exerts protective functions to increase the viability, inhibit the apoptosis and oxidative stress of Aβ25-35-induced PC12 cells by negative regulation of BDNF. ABBREVIATIONS: Aβ25-35: amyloid beta peptide 25-35; AD: Alzheimer's disease; LncRNA BDNF-AS: long non-coding RNA brain-derived neurotrophic factor anti-sense; OS: Oxidative stress. PMID: 29902125 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - June 16, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Shear wave elastography of the brachial plexus roots at the interscalene groove.
CONCLUSION: The elastic modulus of the C5-C7 nerve roots has been determined in asymptomatic individuals and can serve as a reference when studying pathological conditions of these structures. ABBREVIATIONS: BMI: body mass index; SWE: shear wave elastography. PMID: 29873619 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - June 8, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Postural sway in patients with early Parkinson's disease performing cognitive tasks while standing.
CONCLUSION: Our results indicate that patients with early PD have subtle signs of postural instability when their attention is diverted or reduced. In addition, deficits of stereopsis may be common in early PD patients. St Abbreviations: ACC: Accelerometers; ANOVA: Analysis of variance; AP: Antero-posterior; COP: Center of pressure; EC: Eyes closed; ECDT: eyes closed with dual task; EO: Eyes open; EODT: Eyes open with dual task; GDS: Geriatric depression scale; JERK: Jerkiness of sway; ML: Medio-lateral; MMSE: Mini mental state examination; MoCA: Montreal cognitive assessment; PD: Parkinson's disease; PDAbS: PD Patients wi...
Source: Neurological Research - June 6, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The CD40/CD40L system regulates rat cerebral microvasculature after focal ischemia/reperfusion via the mTOR/S6K signaling pathway.
CONCLUSIONS: Our findings indicate that CD40/CD40L system contributes to microvascular thrombosis and brain infarction induced by MCAO and reperfusion. The mTOR/S6K signaling pathway is involved in the regulation of cerebral microvasculature after focal I/R by CD40/CD40L. ABBREVIATIONS: AKT: protein kinase B; CD40L: CD40 ligand; CSF: cerebrospinal fluid; FITC: fluorescein isothiocyanate; I/R: ischemia/reperfusion; MCAO: middle cerebral artery occlusion; mTOR: mechanistic target of rapamycin; PE: P-phycoerythrin; sCD40L: soluble form of CD40L; TNF-a: tumor necrosis factor-alpha; WT: wild type. PMID: 29843579 [PubMed...
Source: Neurological Research - June 2, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Radioprotective activity of glutathione on cognitive ability in X-ray radiated tumor-bearing mice.
Authors: Lu L, Li Z, Zuo Y, Zhao L, Liu B Abstract OBJECTIVES: The use of X-ray for therapeutics always raises the problem of radiation hazards to living beings. In this research, we explored the radioprotective activity of glutathione (GSH) on cognitive ability of X-ray radiated tumor-bearing mice. METHODS: Forty C57BL/6 mice were chosen to establish the GL261 glioma model and randomly divided into four groups: Model group, X-ray group, Pre-GSH group and Pos-GSH group. Morris water maze test was used to test cognitive ability. Moreover, histopathological observation of hippocampus was observed by hematoxylin a...
Source: Neurological Research - June 2, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association of higher waist circumference with milder stroke severity in acute ischaemic stroke.
DISCUSSION: Higher WC at admission is associated with milder baseline stroke severity among patients with acute ischaemic stroke. ABBREVIATIONS: BMI: body mass index; CE: cardioembolism; CI: confidence interval; LAA: large-artery atherosclerosis; NIHSS: National Institutes of Health Stroke Scale; OR: odds ratio; SAO: small-artery occlusion; WC: waist circumference. PMID: 29856277 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - June 2, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Sonographic assessment of optic nerve and ophthalmic vessels in patients with idiopathic intracranial hypertension.
The objective was to explore and monitor reflection of raised ICP in IIH on optic nerve sheath diameter (ONSD), papillary height and ophthalmic vessels hemodynamics, using transorbital sonography (TOS). METHODS: The study included 24 IIH patients and 30 controls. Patients were compared to controls (phase I) then reassessed twice; 1 week and 4 weeks later (phase II). Both groups underwent clinical evaluation and TOS to measure ONSD, papillary elevation, and color Doppler indices of the ophthalmic vessels. Patients underwent lumbar puncture (LP) to measure cerebrospinal fluid (CSF) pressure. RESULTS: ONSD was signifi...
Source: Neurological Research - May 30, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas.
CONCLUSION: The prognostic effect of CHEK1 was validated based on the expression profile data of 615 low-grade glioma and glioblastoma samples. We proposed CHEK1 as prognostic biomarker for HGA. Our work might provide the candidate target for HGA therapy. PMID: 29781781 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Sitagliptin rescues memory deficits in Parkinsonian rats via upregulating BDNF to prevent neuron and dendritic spine loss.
DISCUSSION: Sitagliptin rescued the memory deficits, which was achieved by upregulating BDNF to prevent neuronal death and dendritic spine loss. Our findings indicate that sitagliptin might be a promising potential drug for PD treatment in the future. PMID: 29781786 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between repetitive finger movement and quality of life in Parkinson's disease.
DISCUSSION: Repetitive finger movement is associated with QOL, but more research is needed to better understand the relationship between repetitive finger movement variables and each specific QOL domain. PMID: 29785882 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Hypoxic preconditioning reduces propofol-induced neuroapoptosis via regulation of Bcl-2 and Bax and downregulation of activated caspase-3 in the hippocampus of neonatal rats.
Conclusion: Our results indicate that pretreatment with hypoxic preconditioning prevents propofol-induced neuroapoptosis by increasing the levels of Bcl-2 and decreasing the levels of Bax and cleaved-caspase-3. PMID: 29790425 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Resveratrol prevents high-calorie diet-induced learning and memory dysfunction in juvenile C57BL/6J mice.
Authors: Xu BL, Zhang H, Ma LN, Dong W, Zhao ZW, Zhang JS, Wang YL, Zhang X, Wang R Abstract OBJECTIVE: Because resveratrol (RSV) has been shown to improve learning and memory, so we investigated the potential benefit of RSV on learning and memory deficits in juvenile mice fed with a HC diet and explored the molecular mechanisms underlying this process. METHODS: Six-week-old C57BL/6J mice were divided into three different diet groups: control, HC diet, and HC + RSV diet. Serum insulin and insulin-like growth factor 1 (IGF-1) levels were measured using enzyme-linked immunosorbent assays. Protein expression was e...
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Cerebral ischaemia/reperfusion injury could be managed by using tramadol.
DISCUSSION: Tramadol can ameliorate the histopathological structure of ischaemic tissue in both periods of I/R injury in rat. We suggest further research investigating various dosages with different administration methods of tramadol in stroke should be conducted by adopting different explorative techniques. PMID: 29792388 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Therapist-assisted vision therapy improves outcome for stroke patients with homonymous hemianopia alone or combined with oculomotor dysfunction.
CONCLUSION: Therapist-assisted vision therapy increased peripheral visual awareness. Furthermore patients felt safer in the traffic and in outdoor activities. Reading speed significantly increased, and the ability to keep a moving object in focus improved. PMID: 29792389 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Efficacy of neuromuscular electrical stimulation in improving the negative psychological state in patients with cerebral infarction and dysphagia.
Authors: Zeng Y, Yip J, Cui H, Guan L, Zhu H, Zhang W, Du H, Geng X Abstract Objective To observe the improvement of negative affect disorders in patients with cerebral infarction and dysphagia by neuromuscular electrical stimulation. Methods One hundred and twelve patients with cerebral infarction and dysphagia were selected and randomized into treatment (n = 59) and control (n = 53) groups. Similar swallowing function was found in both groups before treatment: (1) Water-drinking test in the treatment group proved swallowing function Level III in 24 cases, Level IV in 22 cases and Level V in 13...
Source: Neurological Research - May 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of the antiparkinsonism and neuroprotective effects of hydrogen sulfide in acute 6-hydroxydopamine-induced animal model of Parkinson's disease: behavioral, histological and biochemical studies.
CONCLUSION: Our results show that H2S produces significant antiparkinsonism and neuroprotective effects against 6-OHDA neurotoxicity. Since injection of 6-OHDA into MFB produces severe lesion in SN dopaminergic neurons similar to this lesion in the onset of PD in human being, our data recommend H2S as potential therapeutic target for treatment of this disease. PMID: 29726751 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

High thiamine diphosphate level as a protective factor for Alzheimer's disease.
Conclusions TDP is a protective factor for AD and its protective efficacy may be independent of other metabolic factors. The difference of TDP levels between genders may be another possible explanation for the higher prevalence of AD in females. PMID: 29718773 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 3, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats.
In this study, ovariectomized rats were treated with genistein (10 mg/kg) or vehicle daily for two weeks before they received middle cerebral artery occlusion (MCAO) and reperfusion. After 72 hours of reperfusion, the neurological function was evaluated by Garcia test, infarct volume was detected by 2,3,5-triphenyltetrazolium chloride staining, and neuronal damage was detected by Nissl staining. In addition, ROS production and the expression of Nrf2, NQO1 and cleaved-Caspase3 in the ischemic penumbra were detected. RESULTS: The results showed that genistein treatment significantly improved the neurological outcome, red...
Source: Neurological Research - April 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPAR γ after experimental subarachnoid hemorrhage.
Discussion The present study demonstrats that bexarotene administration protects against EBI after SAH, inhibiting cell death, attenuating microglia activation, and alleviating neuroinflammation. The underlying mechanism may partially involve the activation of PPARγ. PMID: 29688151 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Pathogenesis of epileptic seizures and epilepsy after stroke.
Authors: Yang H, Rajah G, Guo A, Wang Y, Wang Q Abstract Stroke is an important cause of seizures and epilepsy in adults, particularly among the elderly. The incidence of stroke increases yearly as life expectancy increases and the number of patients with post-stroke seizures and epilepsy is also rising. Post-stroke epilepsy accounts for nearly 50% of newly diagnosed epilepsy among patients over 60 years of age. With increasing stroke awareness and advanced treatments, increased attention is paid to post-stroke seizures and epilepsy including its diagnosis and treatment. There has been a plethora of research o...
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Antidepressant-like effects of embelin and its possible mechanisms of action in chronic unpredictable stress-induced mice.
Discussion These results indicated that embelin can effectively suppress CUS-induced depressive-like behaviors through increasing BDNF expression, preventing brain from oxidative stress and neuronal inflammation, and normalizing the HPA activity. PMID: 29681219 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Paracellular tightness and the functional expression of efflux transporters P-gp and BCRP in bEnd3 cells.
Conclusions The bEnd3 cell line represents a useful in vitro tool for studying BBB characteristics and drug transport mechanisms at the BBB. PMID: 29683403 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

225 intracranial aneurysms treated with the Low-profile Visualized Intraluminal Support (LVIS) stent: a single-center retrospective study.
Conclusions Our single-center retrospective experience is one of the larger studies to date assessing the LVIS device. Compared with many laser-cut stent studies, the LVIS device had a higher aneurysm complete occlusion rate at follow-up coupled with low complication rates. However, this study was our initial experience with LVIS, larger patient numbers, and longer follow-up will be needed to fully assess the long-term efficacy of LVIS in treating intracranial aneurysms. PMID: 29683412 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association study of CACNA1C polymorphisms with large artery atherosclerotic stroke in Chinese Han population.
Conclusion The results suggested that there was a potential association between CNCNA1C gene and the risk factor of LAA stroke in Chinese Han population. PMID: 29683785 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Real-world treatment of large vessel occlusions: combined outcomes of directly presenting and transferred-in patients to a stroke center.
Conclusion High rates of favorable angiographic and clinical outcomes were found among AIS patients receiving ET in our single-center experience, particularly among transferred in patients. The establishment of a stroke network may help in the efficient transfer and assembly of appropriate resources for eligible patients that are transferred in for ET. PMID: 29683786 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of the association between sexual dysfunction and demyelinating plaque location and number in female multiple sclerosis patients.
Conclusion In our cohort, this difference in SD appears unrelated to the location and number of demyelinating lesions. These findings highlight the importance of the assessment and treatment of psychiatric comorbidities, such as depression and anxiety, in MS patients reporting SD. PMID: 29663848 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 19, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Decreased sleep quality in Parkinson's patients is associated with higher anxiety and depression prevalence and severity, and correlates with pain intensity and quality.
The objective of the present study is to explore the relationship between sleep quality in PD to pain and other NMS that affect quality of life. METHODS: The study included 100 PD patients and 100 age and gender-matched controls assessed for pain severity and pain interference using the Brief Pain Inventory and sleep quality using the Pittsburgh Sleep Quality Index. Participants were also evaluated for their subjective levels of anxiety and depression using the Hospital Anxiety and Depression Scale. RESULTS: PD patients with poor sleep quality had greater pain severity and pain interference than controls and PD pat...
Source: Neurological Research - April 19, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice.
Conclusions Hypothermia is protective following ischemic stroke and can reduce brain tissue loss. Moreover, hypothermia shifts the polarization of microglia from the M1 to the M2 phenotype in the ischemic mice brain. This observed biological phenomenon may partially explain the protective effects seen due to hypothermia in acute ischemic stroke. PMID: 29619889 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Dynamics of Evans blue clearance from cerebrospinal fluid into meningeal lymphatic vessels and deep cervical lymph nodes.
Conclusion Our results demonstrate the dynamic changes of EB in meningeal lymphatic vessels and in deep cervical lymph nodes, thus recapitulating the downstream outflow of intracisternally injected tracer during 3 hours-12 days via dura mater lymphatic vessels towards corresponding extracranial draining system, particularly the deep cervical lymph nodes. PMID: 29619904 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Involvement of dopamine system in the regulation of the brain corticotropin-releasing hormone in paraventricular nucleus in a rat model of chronic visceral pain.
Conclusion These data demonstrated that the VTA played a functional role in chronic visceral pain and depression, and the CRH-containing neurons in hypothalamic PVN may be implicated in the onset and maintenance of the chronic visceral pain and depression via the activation of dopamine in the VTA. PMID: 29623778 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Sildenafil protective effects on high glucose-induced neurotoxicity in PC12 cells: the role of oxidative stress, apoptosis, and inflammation pathways in an in vitro cellular model for diabetic neuropathy.
Conclusion All these data together led us to propose neuroprotective effect of sildenafil is probably through its antioxidant, antiapoptotic, and anti-inflammatory activities. Of course, further studies are required to explain the underlying mechanism of the sildenafil effects. PMID: 29623781 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Restless legs syndrome in patients infected with Helicobacter pylori.
Conclusions Results of the present study indicated that infection with H. pylori is related with the occurrence of RLS. It seems that releasing inflammatory factors, iron deficiency, and small intestinal bacterial overgrowth are some of the involved mechanisms in this pathogenesis. PMID: 29623817 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Brain and disease: an insight into new developments in the pathogenesis and novel therapies for neurological disorders.
Authors: Chandra A, Geng X, Ding Y PMID: 29607735 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 3, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of cardiac autonomic functions in myasthenia gravis.
DISCUSSION: These results suggest that sympathovagal balance has been disturbed in favour of sympathetic tone and that parasympathetic insufficiency has become more prominent. The current findings support the presence of cardiac autonomic involvement in patients with MG. The determination of cardiac autonomic function via noninvasive methods among patients with MG has high predictive value. The identification of autonomic dysfunction at an early stage and the early treatment of cardiovascular diseases can reduce morbidity and mortality. PMID: 29607742 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 3, 2018 Category: Neurology Tags: Neurol Res Source Type: research