The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury model
Discussion covers the apparatus, the test steps, the evaluation indexes, data collection and analysis, animal performance and applications, advantages and disadvantages as well as precautions to eliminate bias wherever possible. We discussed recent studies on TBI-related preconditioning, biomarkers, and optimized behavioral protocols. The neuropsychologic tests employed in clinics were correlated with those used in mouse TBI models. In summary, this review provides a comprehensive, up-to-date reference for TBI researchers to choose the right neurobehavioral protocol according to the research objectives of their translation...
Source: Neurological Research - July 26, 2021 Category: Neurology Authors: Ruoyu Zhang Junming Wang Leo Huang Tom J Wang Yinrou Huang Zefu Li Jinxin He Chen Sun Jing Wang Xuemei Chen Jian Wang Source Type: research

Network meta-analysis on efficacy and safety of different anti-CGRP monoclonal antibody regimens for prophylaxis and treatment of episodic migraine
CONCLUSION: Fremanezumab (225 mg) and Galcanezumab (120 mg) may be the best clinical protocol after a comprehensive assessment.PMID:34281473 | DOI:10.1080/01616412.2021.1940672 (Source: Neurological Research)
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Min Shi Jun Guo Zhaoying Li Honghui Sun Xuhong Yang Dongdong Yang Huan Zhao Source Type: research

(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Neurol Res. 2021 Jul 19:1-13. doi: 10.1080/01616412.2021.1949684. Online ahead of print.ABSTRACTClinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of α7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective α7-nA...
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Deniz Bagdas Gulce Sevdar Zulfiye Gul Rabha Younis Sinan Cavun Han-Shen Tae Marcelo O Ortells Hugo R Arias Mine Sibel Gurun Source Type: research

Network meta-analysis on efficacy and safety of different anti-CGRP monoclonal antibody regimens for prophylaxis and treatment of episodic migraine
CONCLUSION: Fremanezumab (225 mg) and Galcanezumab (120 mg) may be the best clinical protocol after a comprehensive assessment.PMID:34281473 | DOI:10.1080/01616412.2021.1940672 (Source: Neurological Research)
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Min Shi Jun Guo Zhaoying Li Honghui Sun Xuhong Yang Dongdong Yang Huan Zhao Source Type: research

(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Neurol Res. 2021 Jul 19:1-13. doi: 10.1080/01616412.2021.1949684. Online ahead of print.ABSTRACTClinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of α7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective α7-nA...
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Deniz Bagdas Gulce Sevdar Zulfiye Gul Rabha Younis Sinan Cavun Han-Shen Tae Marcelo O Ortells Hugo R Arias Mine Sibel Gurun Source Type: research

Network meta-analysis on efficacy and safety of different anti-CGRP monoclonal antibody regimens for prophylaxis and treatment of episodic migraine
CONCLUSION: Fremanezumab (225 mg) and Galcanezumab (120 mg) may be the best clinical protocol after a comprehensive assessment.PMID:34281473 | DOI:10.1080/01616412.2021.1940672 (Source: Neurological Research)
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Min Shi Jun Guo Zhaoying Li Honghui Sun Xuhong Yang Dongdong Yang Huan Zhao Source Type: research

(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Neurol Res. 2021 Jul 19:1-13. doi: 10.1080/01616412.2021.1949684. Online ahead of print.ABSTRACTClinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of α7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective α7-nA...
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Deniz Bagdas Gulce Sevdar Zulfiye Gul Rabha Younis Sinan Cavun Han-Shen Tae Marcelo O Ortells Hugo R Arias Mine Sibel Gurun Source Type: research

Network meta-analysis on efficacy and safety of different anti-CGRP monoclonal antibody regimens for prophylaxis and treatment of episodic migraine
CONCLUSION: Fremanezumab (225 mg) and Galcanezumab (120 mg) may be the best clinical protocol after a comprehensive assessment.PMID:34281473 | DOI:10.1080/01616412.2021.1940672 (Source: Neurological Research)
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Min Shi Jun Guo Zhaoying Li Honghui Sun Xuhong Yang Dongdong Yang Huan Zhao Source Type: research

(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Neurol Res. 2021 Jul 19:1-13. doi: 10.1080/01616412.2021.1949684. Online ahead of print.ABSTRACTClinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of α7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective α7-nA...
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Deniz Bagdas Gulce Sevdar Zulfiye Gul Rabha Younis Sinan Cavun Han-Shen Tae Marcelo O Ortells Hugo R Arias Mine Sibel Gurun Source Type: research

Network meta-analysis on efficacy and safety of different anti-CGRP monoclonal antibody regimens for prophylaxis and treatment of episodic migraine
CONCLUSION: Fremanezumab (225 mg) and Galcanezumab (120 mg) may be the best clinical protocol after a comprehensive assessment.PMID:34281473 | DOI:10.1080/01616412.2021.1940672 (Source: Neurological Research)
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Min Shi Jun Guo Zhaoying Li Honghui Sun Xuhong Yang Dongdong Yang Huan Zhao Source Type: research

(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Neurol Res. 2021 Jul 19:1-13. doi: 10.1080/01616412.2021.1949684. Online ahead of print.ABSTRACTClinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of α7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective α7-nA...
Source: Neurological Research - July 20, 2021 Category: Neurology Authors: Deniz Bagdas Gulce Sevdar Zulfiye Gul Rabha Younis Sinan Cavun Han-Shen Tae Marcelo O Ortells Hugo R Arias Mine Sibel Gurun Source Type: research

Overlapping stent-assisted coil embolization for vertebrobasilar dissecting aneurysms: a single-center study
Neurol Res. 2021 Jul 18:1-7. doi: 10.1080/01616412.2021.1922172. Online ahead of print.ABSTRACTEffective treatment strategies for vertebrobasilar dissecting aneurysms (VBDAs) remain controversial due to their high morbidity and mortality. The aim of the present study was to evaluate the efficacy of overlapping stent-assisted coil embolization (OSCE) in VBDA patients. A total of 42 patients with VBDA were retrospectively examined by OSCE from May 2015 to August 2019. Patients' clinical and radiological parameters were assessed at discharge and during interim follow-up. Safety, technical feasibility and follow-up clinical an...
Source: Neurological Research - July 19, 2021 Category: Neurology Authors: Guangyao Shi Shancai Xu Ilgiz Gareev Zhiyong Ji Wu Pei Guang Zhang Jingtao Qi Rui Chen Shaodong Liang Yan Gu Chunlei Wang Source Type: research

The effect of dexketoprofen trometamol on WAG/Rij rats with absence epilepsy (dexketoprofen in absence epilepsy)
Neurol Res. 2021 Jul 18:1-10. doi: 10.1080/01616412.2021.1952510. Online ahead of print.ABSTRACTAIM: Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present study aimed to assess the efficiency of DEX on WAG/Rij rats by electrophysiologically and behaviorally.MATERIAL AND METHODS: Twenty-eight male WAG/Rij rats were used. The effects of acute treatment with DEX (5, 25, and 50 mg/kg, i.p) on absence-like seizures, and related psychiatric comorbidity were assessed. The ECoG recording was taken for 180 min bef...
Source: Neurological Research - July 19, 2021 Category: Neurology Authors: Aras Erdil Mustafa Sami Demirsoy Sefa Çolak Esra Duman Orhan S ümbül Hatice Aygun Source Type: research

Overlapping stent-assisted coil embolization for vertebrobasilar dissecting aneurysms: a single-center study
Neurol Res. 2021 Jul 18:1-7. doi: 10.1080/01616412.2021.1922172. Online ahead of print.ABSTRACTEffective treatment strategies for vertebrobasilar dissecting aneurysms (VBDAs) remain controversial due to their high morbidity and mortality. The aim of the present study was to evaluate the efficacy of overlapping stent-assisted coil embolization (OSCE) in VBDA patients. A total of 42 patients with VBDA were retrospectively examined by OSCE from May 2015 to August 2019. Patients' clinical and radiological parameters were assessed at discharge and during interim follow-up. Safety, technical feasibility and follow-up clinical an...
Source: Neurological Research - July 19, 2021 Category: Neurology Authors: Guangyao Shi Shancai Xu Ilgiz Gareev Zhiyong Ji Wu Pei Guang Zhang Jingtao Qi Rui Chen Shaodong Liang Yan Gu Chunlei Wang Source Type: research

The effect of dexketoprofen trometamol on WAG/Rij rats with absence epilepsy (dexketoprofen in absence epilepsy)
Neurol Res. 2021 Jul 18:1-10. doi: 10.1080/01616412.2021.1952510. Online ahead of print.ABSTRACTAIM: Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present study aimed to assess the efficiency of DEX on WAG/Rij rats by electrophysiologically and behaviorally.MATERIAL AND METHODS: Twenty-eight male WAG/Rij rats were used. The effects of acute treatment with DEX (5, 25, and 50 mg/kg, i.p) on absence-like seizures, and related psychiatric comorbidity were assessed. The ECoG recording was taken for 180 min bef...
Source: Neurological Research - July 19, 2021 Category: Neurology Authors: Aras Erdil Mustafa Sami Demirsoy Sefa Çolak Esra Duman Orhan S ümbül Hatice Aygun Source Type: research

Neurological symptoms and findings in COVID-19: a prospective clinical study
This study was designed as a prospective study. Hospitalized COVID-19 rRt-PCR positive patients in the ward and ICU were included in the study. A 54-item questionnaire was used to evaluate the patients. Patients were examined within 3 hours of hospitalization.RESULTS: A total of 379 patients were included in the study. The mean age of the patients was 56.1 ± 17.8. 89 of the patients were in intensive care. At least one general symptom was recorded in 95.5% of patients. The most common neurologic symptoms were myalgia (48.5%), headache (39.6%), anosmia (34.8%), and dysgeusia (34%). Neurological symptoms in ICU patien...
Source: Neurological Research - July 16, 2021 Category: Neurology Authors: Cansu K öseoğlu Toksoy Tunzala Yavuz Semiha Orhan Petek Şarlak Konya Derya Korkmaz Havva T ünay Erhan Bozkurt İbrahim Güven Coşğun Ne şe Demirtürk İsmet Doğan Ülkü Türk Börü Source Type: research

Incidence and prevalence of neuromyelitis optica spectrum disorders in Slovakia
CONCLUSION: : The NMOSD epidemiological situation in Slovakia is comparable to those reported from other Caucasian populations.PMID:34261427 | DOI:10.1080/01616412.2021.1952741 (Source: Neurological Research)
Source: Neurological Research - July 15, 2021 Category: Neurology Authors: Jarmila Szilasiov á Jakub Gazda Andrea Cimprichov á Anna Cvengro šová Vladim ír Donáth Miriam Fedi čová Ladislav Gur čík Viera Han činová Franti šek Jurčaga Edita Kahancov á Ema Kantorov á Martin Karl ík Eleon óra Klímová Slavom íra K Source Type: research

Macrophage Migration Inhibitory Factor - 173 G/C Polymorphism is Associated With The Age of Onset and Insight in Schizophrenia in the Turkish Population
CONCLUSIONS: MIF -173 G/C polymorphism may be associated with the age of illness onset and impairment of insight in SCZ.PMID:34264160 | DOI:10.1080/01616412.2021.1948748 (Source: Neurological Research)
Source: Neurological Research - July 15, 2021 Category: Neurology Authors: Hasan Mervan Aytac Yasemin Oyaci Menekse Sila Yazar Sacide Pehlivan Source Type: research

Incidence and prevalence of neuromyelitis optica spectrum disorders in Slovakia
CONCLUSION: : The NMOSD epidemiological situation in Slovakia is comparable to those reported from other Caucasian populations.PMID:34261427 | DOI:10.1080/01616412.2021.1952741 (Source: Neurological Research)
Source: Neurological Research - July 15, 2021 Category: Neurology Authors: Jarmila Szilasiov á Jakub Gazda Andrea Cimprichov á Anna Cvengro šová Vladim ír Donáth Miriam Fedi čová Ladislav Gur čík Viera Han činová Franti šek Jurčaga Edita Kahancov á Ema Kantorov á Martin Karl ík Eleon óra Klímová Slavom íra K Source Type: research

Macrophage Migration Inhibitory Factor - 173 G/C Polymorphism is Associated With The Age of Onset and Insight in Schizophrenia in the Turkish Population
CONCLUSIONS: MIF -173 G/C polymorphism may be associated with the age of illness onset and impairment of insight in SCZ.PMID:34264160 | DOI:10.1080/01616412.2021.1948748 (Source: Neurological Research)
Source: Neurological Research - July 15, 2021 Category: Neurology Authors: Hasan Mervan Aytac Yasemin Oyaci Menekse Sila Yazar Sacide Pehlivan Source Type: research

The effects of neuronal cell differentiation on TRPM7, TRPM8 and TRPV1 channels in the model of Parkinson's disease
Neurol Res. 2021 Jul 14:1-14. doi: 10.1080/01616412.2021.1952512. Online ahead of print.ABSTRACTTransient Receptor Potential Melastatin-like 7 (TRPM7), Transient Receptor Potential Melastatin-like 8 (TRPM8) and Transient Receptor Potential Vanilloid-like 1 (TRPV1) channels are expressed in neurological tissues such as brain cortex, dorsal root ganglion and hippocampal neurons and involved in several neurological diseases. The SH-SY5Y neuronal cell line is frequently used as a cellular model of neurodegenerative diseases including Parkinson's disease. The differentiated SH-SY5Y cells have much neuronal structure, function a...
Source: Neurological Research - July 14, 2021 Category: Neurology Authors: Ahmi Öz Ömer Çelik Source Type: research

21st Century Early Adult (55-74) Deaths from Brain-Disease-Deaths Compared to All Other Cause Mortality in the Major Western Countries - Exposing a Hidden Epidemic
DISCUSSION: Positive news is that AOC are down across all investigated countries in the 21st century. However, the extent of the EAD rises in just 16 years indicates that these BDD conditions are starting earlier suggesting multiple interactive environmental factors impacting upon brain related diseases.PMID:34253141 | DOI:10.1080/01616412.2021.1943121 (Source: Neurological Research)
Source: Neurological Research - July 13, 2021 Category: Neurology Authors: Colin Pritchard Lars Hansen Anne Silk Emily Rosenorn-Lanng Source Type: research

Circulating granulocyte colony-stimulating factor and functional outcome after ischemic stroke: an observational study
Neurol Res. 2021 Jul 13:1-10. doi: 10.1080/01616412.2021.1948766. Online ahead of print.ABSTRACTObjectives: While granulocyte colony-stimulating factor (G-CSF) has shown beneficial effects in experimental ischemic stroke (IS), these effects have not been reproduced clinically. Small-to-medium-sized observational studies have reported varying associations for G-CSF with stroke severity and post-stroke functional outcome, prompting their investigation in a larger study.Methods: Endogenous serum G-CSF (S-GCSF) was measured in the acute phase and after 3 months in patients with IS (N = 435; 36% females; mean age, 57 years) fro...
Source: Neurological Research - July 13, 2021 Category: Neurology Authors: Alexander Wall Olof Anger Katarina Jood Christian Blomstrand Ulf Andreasson Kaj Blennow Henrik Zetterberg J örgen Isgaard Christina Jern N David Åberg Johan Svensson Source Type: research

Safety and efficacy of intravascular therapy in patients with progressive stroke caused by intracranial large vascular occlusion exceeding the time window of 24 hours
CONCLUSION: In patients with progressive stroke caused by large intracranial vascular occlusion exceeding 24 hours, endovascular therapy probably results in improved efficacy at 90 days compared with drug therapy, without increasing the rates of adverse effects.PMID:34252005 | DOI:10.1080/01616412.2021.1948768 (Source: Neurological Research)
Source: Neurological Research - July 12, 2021 Category: Neurology Authors: Yukang Zhang Yang He Shuang Chen Wenjie Zhao Yongmin Chen Yan Liu Huijuan Liu Yi Cai Lin Ma Qifu Li Source Type: research

ASPECT scores of patients with focal intracerebral hemorrhage were correlated with their short- and medium-term functional outcomes
CONCLUSIONS: A low ASPECTS-H was an indicator of poor short-term and long-term functional outcomes of ICH.PMID:34240679 | DOI:10.1080/01616412.2021.1948747 (Source: Neurological Research)
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Qiuyue Zheng Xiaojie Liu Ke Yan Liang He Yingzhu Chen Source Type: research

Calcium-phosphate homeostasis in secondary progressive multiple sclerosis patients during mitoxantrone therapy
Neurol Res. 2021 Jul 9:1-6. doi: 10.1080/01616412.2021.1949683. Online ahead of print.ABSTRACTOBJECTIVES: To assess calcium-phosphate parameters in SPMS patients treated with mitoxantrone (MTX).METHODS: Thirty eight SPMS patients eligible for MTX therapy in the Department of Neurology in Zabrze, Poland were enrolled in a prospective study from March 2016 to November 2019. The parameters of serum calcium-phosphate metabolism and the neurological status according to the Expanded Disability Status Scale (EDSS) were assessed. In patients with hypovitaminosis D, vitamin D (VitD) supplementation was introduced (4000 IU/day for 1...
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Martyna Lis Natalia Niedziela Maria Nowak-Kiczmer Katarzyna Kubicka-B ączyk Monika Adamczyk-Sowa Source Type: research

Multiple sclerosis and neuromyelitis optica spectrum disorder testing and treatment availability in Latin America
CONCLUSION: The present study allows an understanding of the delivery of care for MS and NMOSD in the region.PMID:34240685 | DOI:10.1080/01616412.2021.1949686 (Source: Neurological Research)
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Juan I Rojas Fernando Gracia Liliana Patrucco Ricardo Alonso Edgar Carnero Contentti Edgardo Cristiano Source Type: research

ASPECT scores of patients with focal intracerebral hemorrhage were correlated with their short- and medium-term functional outcomes
CONCLUSIONS: A low ASPECTS-H was an indicator of poor short-term and long-term functional outcomes of ICH.PMID:34240679 | DOI:10.1080/01616412.2021.1948747 (Source: Neurological Research)
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Qiuyue Zheng Xiaojie Liu Ke Yan Liang He Yingzhu Chen Source Type: research

Calcium-phosphate homeostasis in secondary progressive multiple sclerosis patients during mitoxantrone therapy
Neurol Res. 2021 Jul 9:1-6. doi: 10.1080/01616412.2021.1949683. Online ahead of print.ABSTRACTOBJECTIVES: To assess calcium-phosphate parameters in SPMS patients treated with mitoxantrone (MTX).METHODS: Thirty eight SPMS patients eligible for MTX therapy in the Department of Neurology in Zabrze, Poland were enrolled in a prospective study from March 2016 to November 2019. The parameters of serum calcium-phosphate metabolism and the neurological status according to the Expanded Disability Status Scale (EDSS) were assessed. In patients with hypovitaminosis D, vitamin D (VitD) supplementation was introduced (4000 IU/day for 1...
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Martyna Lis Natalia Niedziela Maria Nowak-Kiczmer Katarzyna Kubicka-B ączyk Monika Adamczyk-Sowa Source Type: research

Multiple sclerosis and neuromyelitis optica spectrum disorder testing and treatment availability in Latin America
CONCLUSION: The present study allows an understanding of the delivery of care for MS and NMOSD in the region.PMID:34240685 | DOI:10.1080/01616412.2021.1949686 (Source: Neurological Research)
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Juan I Rojas Fernando Gracia Liliana Patrucco Ricardo Alonso Edgar Carnero Contentti Edgardo Cristiano Source Type: research

ASPECT scores of patients with focal intracerebral hemorrhage were correlated with their short- and medium-term functional outcomes
CONCLUSIONS: A low ASPECTS-H was an indicator of poor short-term and long-term functional outcomes of ICH.PMID:34240679 | DOI:10.1080/01616412.2021.1948747 (Source: Neurological Research)
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Qiuyue Zheng Xiaojie Liu Ke Yan Liang He Yingzhu Chen Source Type: research

Calcium-phosphate homeostasis in secondary progressive multiple sclerosis patients during mitoxantrone therapy
Neurol Res. 2021 Jul 9:1-6. doi: 10.1080/01616412.2021.1949683. Online ahead of print.ABSTRACTOBJECTIVES: To assess calcium-phosphate parameters in SPMS patients treated with mitoxantrone (MTX).METHODS: Thirty eight SPMS patients eligible for MTX therapy in the Department of Neurology in Zabrze, Poland were enrolled in a prospective study from March 2016 to November 2019. The parameters of serum calcium-phosphate metabolism and the neurological status according to the Expanded Disability Status Scale (EDSS) were assessed. In patients with hypovitaminosis D, vitamin D (VitD) supplementation was introduced (4000 IU/day for 1...
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Martyna Lis Natalia Niedziela Maria Nowak-Kiczmer Katarzyna Kubicka-B ączyk Monika Adamczyk-Sowa Source Type: research

Multiple sclerosis and neuromyelitis optica spectrum disorder testing and treatment availability in Latin America
CONCLUSION: The present study allows an understanding of the delivery of care for MS and NMOSD in the region.PMID:34240685 | DOI:10.1080/01616412.2021.1949686 (Source: Neurological Research)
Source: Neurological Research - July 9, 2021 Category: Neurology Authors: Juan I Rojas Fernando Gracia Liliana Patrucco Ricardo Alonso Edgar Carnero Contentti Edgardo Cristiano Source Type: research

Activation of SK3 channel plays a pivotal role in modulation of trigeminal neuralgia
Conclusion: The SK3 channel may play a pivotal role in the pathogenesis of trigeminal neuralgia, and it may be one of the potential targets for the treatment of trigeminal neuralgia.PMID:34233598 | DOI:10.1080/01616412.2021.1948765 (Source: Neurological Research)
Source: Neurological Research - July 8, 2021 Category: Neurology Authors: Jiaomei Zhao Yue Zhang Xiangbo Liu Yong Rao Jia Fu Lu Hua Cehua Ou Source Type: research

Orexin one receptors within the basolateral amygdala are involved in the modulation of cognitive deficits associated with a migraine-like state in rats
CONCLUSIONS: Overall, the data provided an emerging role for the orexin system within BLA in the modulation of cognitive decline comorbid with migraine in rats.PMID:34233602 | DOI:10.1080/01616412.2021.1949687 (Source: Neurological Research)
Source: Neurological Research - July 8, 2021 Category: Neurology Authors: Khadijeh Askari-Zahabi Mehdi Abbasnejad Razieh Kooshki Saeed Esmaeili-Mahani Source Type: research

Risk factors for potential drug-drug interactions in patients with myasthenia gravis
Neurol Res. 2021 Jul 7:1-8. doi: 10.1080/01616412.2021.1948767. Online ahead of print.ABSTRACTOBJECTIVES: Our aim was to determine risk factors for and frequency of potential drug-drug interactions (pDDIs) among hospitalized patients with myasthenia gravis (MG).METHODS: This was a retrospective cross-sectional study of the-first time hospitalized MG patients or patients hospitalized because of the exacerbation of MG at the Neurology Clinic of the Clinical Center of Serbia, Belgrade. Medical records and discharge summaries of hospitalized MG patients over a 10-year period were reviewed. The pDDIs were identified by means of...
Source: Neurological Research - July 8, 2021 Category: Neurology Authors: Dejan Z Aleksi ć Milo š N Milosavljević Sr đan M Stefanović Andriana Bukonji ć Jovana Z Milosavljevi ć Slobodan M Jankovi ć Ivo Bo žović Stojan Peri ć Dragana Lavrni ć Source Type: research

Activation of SK3 channel plays a pivotal role in modulation of trigeminal neuralgia
Conclusion: The SK3 channel may play a pivotal role in the pathogenesis of trigeminal neuralgia, and it may be one of the potential targets for the treatment of trigeminal neuralgia.PMID:34233598 | DOI:10.1080/01616412.2021.1948765 (Source: Neurological Research)
Source: Neurological Research - July 8, 2021 Category: Neurology Authors: Jiaomei Zhao Yue Zhang Xiangbo Liu Yong Rao Jia Fu Lu Hua Cehua Ou Source Type: research

Orexin one receptors within the basolateral amygdala are involved in the modulation of cognitive deficits associated with a migraine-like state in rats
CONCLUSIONS: Overall, the data provided an emerging role for the orexin system within BLA in the modulation of cognitive decline comorbid with migraine in rats.PMID:34233602 | DOI:10.1080/01616412.2021.1949687 (Source: Neurological Research)
Source: Neurological Research - July 8, 2021 Category: Neurology Authors: Khadijeh Askari-Zahabi Mehdi Abbasnejad Razieh Kooshki Saeed Esmaeili-Mahani Source Type: research

Risk factors for potential drug-drug interactions in patients with myasthenia gravis
Neurol Res. 2021 Jul 7:1-8. doi: 10.1080/01616412.2021.1948767. Online ahead of print.ABSTRACTOBJECTIVES: Our aim was to determine risk factors for and frequency of potential drug-drug interactions (pDDIs) among hospitalized patients with myasthenia gravis (MG).METHODS: This was a retrospective cross-sectional study of the-first time hospitalized MG patients or patients hospitalized because of the exacerbation of MG at the Neurology Clinic of the Clinical Center of Serbia, Belgrade. Medical records and discharge summaries of hospitalized MG patients over a 10-year period were reviewed. The pDDIs were identified by means of...
Source: Neurological Research - July 8, 2021 Category: Neurology Authors: Dejan Z Aleksi ć Milo š N Milosavljević Sr đan M Stefanović Andriana Bukonji ć Jovana Z Milosavljevi ć Slobodan M Jankovi ć Ivo Bo žović Stojan Peri ć Dragana Lavrni ć Source Type: research

Gadolinium enhancement of atherosclerotic plaque in the intracranial artery
Conclusion: Enhanced plaques were more often observed in culprit plaques, and non-enhanced plaques were more often observed in non-culprit plaques. Moreover, significant plaque enhancement and severe ICAS were closely associated with acute ischemic events.PMID:34229565 | DOI:10.1080/01616412.2021.1949682 (Source: Neurological Research)
Source: Neurological Research - July 7, 2021 Category: Neurology Authors: Yue Lu Meng-Fan Ye Jie-Ji Zhao Shan-Shan Diao Tan Li Dong-Xue Ding Lu-Lu Zhang Fei-Rong Yao Yan Kong Zhuan Xu Source Type: research

Clinical features and real-world outcomes of Guillain-Barr é syndrome in the Philippines
CONCLUSION: Our study presented the first comprehensive information regarding the features and outcomes of GBS patients in the Philippines.ABBREVIATIONS: AIDP - Acute inflammatory demyelinating polyneuropathy; AMAN - Acute motor axonal neuropathy; AMSAN - Acute motor and sensory axonal neuropathy; GBS - Guillain-Barré syndrome; GBS-DS - Guillain-Barré syndrome disability scale; ICU - Intensive care unit; IVIg - Intravenous immunoglobulin; MFS - Miller-Fisher syndrome; PGH - Philippine General Hospital; TPE - Therapeutic plasma exchange.PMID:34229572 | DOI:10.1080/01616412.2021.1948750 (Source: Neurological Research)
Source: Neurological Research - July 7, 2021 Category: Neurology Authors: Adrian I Espiritu Karl Josef Ni ño J Separa Francis Jordan C Milla Karen Joy B Adiao Carl Froilan D Leochico Roland Dominic G Jamora Source Type: research

An antihypertensive agent benidipine is an effective neuroprotective and antiepileptic agent: an experimental rat study
Neurol Res. 2021 Jul 5:1-12. doi: 10.1080/01616412.2021.1949685. Online ahead of print.ABSTRACTBACKGROUND: Benidipine is an L, N and T type calcium channel blocker drug that is widely used as an antihypertensive drug.OBJECTIVE: For the first time in the literature, it was aimed to investigate the effectiveness of benidipine in controlling epileptic seizure and preventing the development of neurodegeneration in epilepsy.METHODS: An experimentally epilepsy model was produced with pentylenetetrazole, and rats were divided into seven groups, in different benidipine treatment doses or with valproic acid combinations. The epilep...
Source: Neurological Research - July 6, 2021 Category: Neurology Authors: Mehmet Nuri Ko çak Remzi Arslan Abdulmecit Albayrak Erdal Tekin Mustafa Bayraktar Muhammet Çelik Z ülküf Kaya H üseyin Bekmez Taha Tavaci Source Type: research

Three-dimensional anatomic analysis and navigation templates for C1 pedicle screw placement perpendicular to the coronal plane: a retrospective study
CONCLUSION: A pedicle screw trajectory perpendicular to the coronal plane can be quickly obtained based on the perspective of 3D models. The technique of screw placement perpendicular to the coronal plane assisted by navigation templates has a shorter operative time, lessintraoperative fluoroscopy and a higher safety of screw placement than traditional surgery.PMID:34227928 | DOI:10.1080/01616412.2021.1948741 (Source: Neurological Research)
Source: Neurological Research - July 6, 2021 Category: Neurology Authors: Chao Wu Jiayan Deng Bofang Zeng Yuan Fang Zhu Tao Li Source Type: research

An antihypertensive agent benidipine is an effective neuroprotective and antiepileptic agent: an experimental rat study
Neurol Res. 2021 Jul 5:1-12. doi: 10.1080/01616412.2021.1949685. Online ahead of print.ABSTRACTBACKGROUND: Benidipine is an L, N and T type calcium channel blocker drug that is widely used as an antihypertensive drug.OBJECTIVE: For the first time in the literature, it was aimed to investigate the effectiveness of benidipine in controlling epileptic seizure and preventing the development of neurodegeneration in epilepsy.METHODS: An experimentally epilepsy model was produced with pentylenetetrazole, and rats were divided into seven groups, in different benidipine treatment doses or with valproic acid combinations. The epilep...
Source: Neurological Research - July 6, 2021 Category: Neurology Authors: Mehmet Nuri Ko çak Remzi Arslan Abdulmecit Albayrak Erdal Tekin Mustafa Bayraktar Muhammet Çelik Z ülküf Kaya H üseyin Bekmez Taha Tavaci Source Type: research

Three-dimensional anatomic analysis and navigation templates for C1 pedicle screw placement perpendicular to the coronal plane: a retrospective study
CONCLUSION: A pedicle screw trajectory perpendicular to the coronal plane can be quickly obtained based on the perspective of 3D models. The technique of screw placement perpendicular to the coronal plane assisted by navigation templates has a shorter operative time, lessintraoperative fluoroscopy and a higher safety of screw placement than traditional surgery.PMID:34227928 | DOI:10.1080/01616412.2021.1948741 (Source: Neurological Research)
Source: Neurological Research - July 6, 2021 Category: Neurology Authors: Chao Wu Jiayan Deng Bofang Zeng Yuan Fang Zhu Tao Li Source Type: research

Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets
This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups.Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients.Results: IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8...
Source: Neurological Research - July 2, 2021 Category: Neurology Authors: Secil Ak Aksoy Melis Mutlu Berrin Tunca Hasan Kocaeli Mevlut Ozgur Taskapilioglu Ahmet Bekar Cagla Tekin Omer Gokay Argadal Muhammet Nafi Civan İsmail Seckin Kaya P ınar Eser Ocak Sahsine Tolunay Source Type: research