Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury.
Authors: Afshari K, Dehdashtian A, Haddad NS, Jazaeri SZ, Ursu DC, Khalilzadeh M, Haj-Mirzaian A, Shakiba S, Burns TC, Tavangar SM, Ghasemi M, Dehpour AR Abstract OBJECTIVES: To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this effect. METHODS: Using an aneurysm mini-clip model of contusive SCI, T9-10 laminectomies were performed for 60 male rats. Animals were divided into six experimental groups (n = 10 per group) as follows: a minocycline administered positive control group, a saline-vehicl...
Source: Neurological Research - September 17, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Leisure time physical activity in persons with spinal cord injury across the seasons.
CONCLUSION: LTPA in persons with SCI differs significantly in relation to the seasons throughout a year. The season of the year should be considered in future studies and interventions on LTPA in adults with SCI. PMID: 32912101 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Peripapillary microperimetry for the diagnosis and follow-up of papilledema in cases treated for idiopathic intracranial hypertension.
This study was a prospective non-comparative observational case series of patients with IIH. All patients underwent full ophthalmological examination, radiological imaging, and lumbar puncture, as well as microperimetric measurements around the optic nerve head. Patients were classified into a medical group, treated by weight reduction and acetazolamide, and a surgical group, treated by optic nerve sheath fenestration. Peripapillary microperimetric examinations were done at presentation and after one-month of treatment. Findings were compared to values obtained from an age-matched healthy control group. RESULTS: The st...
Source: Neurological Research - September 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The impact of botulinum toxin type A in the treatment of drooling in children with cerebral palsy secondary to Congenital Zika Syndrome: an observational study.
Authors: Sales HF, Cerqueira C, Vaz D, Medeiros-Rios D, Armani-Franceschi G, Lucena PH, Sternberg C, Nóbrega AC, Luz C, Fonseca D, Carvalho AL, Monteiro L, Siqueira IC, Bandeira ID, Lucena R Abstract OBJECTIVE: The main aim of this study was to determine the impact of botulinum toxin A (BTX-A) on severity and frequency of drooling in children with Cerebral Palsy (CP) secondary to Congenital Zika Syndrome (CZS). METHODS: This is a prospective longitudinal observational study including 23 children who received bilateral injections of BTX in the parotid and submandibular glands. The Thomas-Stonell & Gre...
Source: Neurological Research - September 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The role of arm volumes evaluation in the functional outcome and patient satisfaction following surgical repair of the brachial plexus traumatic injuries.
CONCLUSIONS: Previous studies were mainly focused on the functional outcome and quality of life; although related to both, arm volumes in patients with brachial plexus injuries were not analyzed before. Significant differences between the operated arm and the healthy arm volumes, as well as between the various types of palsy, found in the present study should trigger further prospective research in relation to neurophysiology, useful functional recovery and quality of life. PMID: 32900291 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 10, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Impact of surgical treatment on the performance status of patients with high-grade gliomas.
CONCLUSION: According to our study, the first operation has a beneficial effect on the performance status in patients with HGG. The results for the second operation are more ambiguous, but there is no clear evidence for worsening of the KPS score after the second intervention. These results were relevant for all age groups, so we may expect amelioration in the performance status even in older patients. PMID: 32892718 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Biportal endoscopic technique in the treatment of spinal stenosis: early clinical experiences and results.
DISCUSSION: Biportal endoscopic technique was developed to fulfil the requirements of minimally invasive techniques. Our results indicate this method may be highly effective for the treatment of lumbar spinal stenosis and an alternative to conventional microsurgical decompression; however, our study limited by its retrospective manner and small population size. PMID: 32892719 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Microsurgical approach for symptomatic brain AVMs - single center experience.
Authors: Gorgan RM, Petrescu GED, Brehar FM Abstract OBJECTIVES: Brain arteriovenous malformations (AVMs) represent high-flow vascular lesions made up of a complex network of feeding arteries and draining veins interposed by a nidus and without a capillary bed. The management of the AVMs represents a challenge, and the optimal treatment should be considered based on the particularities of each AVM. This paper aims to provide outcome data for the cohort of patients with AVMs that underwent surgical treatment. METHODS: A retrospective review of patients who presented with AVMs between 2001 and 2019 was conducted....
Source: Neurological Research - September 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Endoscopic supracerebellar infratentorial approach to pineal and posterior third ventricle lesions in prone position with head extension: a technical note.
CONCLUSIONS: The endoscopic SCIT approach enables effective and safe removal of pineal and posterior third ventricle lesions, even of moderate dimensions (up to 3 cm). The endoscope guarantees a detailed view and illumination of the deep-seated structures. The tumour resection can be performed with bimanual use of microsurgical instruments. PMID: 32892737 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Comparison of radiological versus clinical cerebral vasospasm after aneurysmal subarachnoid hemorrhage: is vasospasm always present?
CONCLUSIONS: This study confirms that CV always follows aSAH. Future research into pathophysiology of CV is needed in order to determine exact treatment strategies and targets so treatment towards zero mortality can be achieved. PMID: 32893749 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Predictors, causes and outcome of 30-day readmission among acute ischemic stroke.
Authors: Qiu X, Xue X, Xu R, Wang J, Zhang L, Zhang L, Zhao W, He L Abstract BACKGROUND AND PURPOSE: Readmission within 30 days of index acute ischemic stroke (AIS) after hospitalization increases the burden on patients and healthcare expense. The purpose of our study was to investigate predictors and causes of 30-day readmission after AIS and investigate hospitalization expenses, length of stay (LOS) and in-hospital mortality of 30-day readmission. METHODS: This is a multicenter retrospective study. AIS were captured by International Classification of Diseases, Tenth Revision (ICD-10) diagn...
Source: Neurological Research - September 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Cognitive impairment and neuropsychiatric manifestations of neurobrucellosis.
This study aimed to reveal insight into the unclear areas of the diagnosis in neurobrucellosis and to decide the neuropsychiatric manifestations and cognitive impairment among patients with brucellosis. METHODS: 82 patients with serologically confirmed brucellosis were included and divided into two groups according to the neuropsychiatric manifestations, the first group included 18 patients with neurobrucellosis and the second group included 64 patients with non-neurobrucellosis. Both groups were compared regarding the general symptoms and neurological symptoms and signs. Cognitive impairment in both groups was assesse...
Source: Neurological Research - August 30, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Cervical, thoracolumbar, and sacral spine trauma classifications: past, present, and future.
CONCLUSION: For widespread acceptance and adoption in the clinical setting, future spinal trauma scoring classification will need to remain simple, highly reproducible, and impart information with regard to clinical decision-making and prognosis that may be effectively communicated across each medical specialty involved in the care of these patients. PMID: 32758096 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The pursuit of cures for cerebral disease persists, even through a pandemic.
Authors: Stone C, Geng X, Ding Y PMID: 32749947 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 5, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Icariin sustains the proliferation and differentiation of A β25-35-treated hippocampal neural stem cells via the BDNF-TrkB-ERK/Akt signaling pathway.
DISCUSSION: ICA promoted the proliferation and differentiation of Aβ25-35-treated hippocampal neural stem cells through BDNF-TrkB-ERK/Akt signaling pathway. The current findings might contribute to the treatment of AD. PMID: 32727295 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 1, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprosthesis for individuals with spinal cord injury.
CONCLUSION:   The results to date show that implanted neuroprostheses can have a significant impact on the health, function, and quality of life for individuals with SCI. A key focus for the future is to make implanted neuroprostheses broadly available to the SCI population. PMID: 32727296 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 1, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.
Authors: Kumar A, Sharma R, Misra S, Nath M, Kumar P Abstract Studies on relationship between methylenetetrahydrofolate reductase gene (MTHFR) gene A1298C polymorphism with the risk of ischemic as well as hemorrhagic stroke have shown discordant results. Present meta-analysis was aimed to clarify the relationship between MTHFR gene A1298C polymorphism with risk of stroke. A comprehensive literature search for all published articles was performed in electronic database including PubMed, EMbase, Cochrane Library, Trip Databases, Worldwide Science, CINAHL, and Google Scholar up to 31st  December 2019. P...
Source: Neurological Research - August 1, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
CONCLUSIONS: The following literature review focuses on the discoveries made in ascertaining the different implications of miRNAs and candidate gene SNPs in the formation and evolution of brain AVMs, as well as highlighting the possible directions of future research and biological treatment. ABBREVIATIONS: ACVRL1/ALK1: activin receptor-like kinase 1; Akt: protein kinase B; ANGPTL4: angiopoietin-like 4; ANRIL: antisense noncoding RNA in the INK4 locus; AVM: arteriovenous malformation; AVM-BEC: arteriovenous malformation brain endothelial cell; BRCA1: breast cancer type 1 susceptibility protein; CCS: case-control study; ...
Source: Neurological Research - July 31, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Prospective randomized appraisal of the best pain relief option after L4/L5 discectomy.
Authors: Sajko T, Rotim K, Kurtovic B, Rotim C, Rotim A Abstract OBJECTIVES: To determine the efficacy of paracetamol and tramadol analgesia via patient controlled pump and intermittent administration using the Short-Form McGill Pain Questionnaire after L4/L5 discectomy in neurosurgical patients. METHODS: Fourteen months prospective quantitative study with 200 neurosurgical patients' participation who underwent elective discectomy of the L4/L5 intervertebral disc extrusion. The study was conducted due to a patient-controlled analgesia pump and intermittent analgesia application. Pain was assessed using the Shor...
Source: Neurological Research - July 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

TRAIL-conjugated silver nanoparticles sensitize glioblastoma cells to TRAIL by regulating CHK1 in the DNA repair pathway.
CONCLUSION: These results suggest that TRAIL sensitivity of TR cells can be enhanced by conjugation of TRAIL with AgNPs, which would be a novel therapeutic approach to sensitize TRAIL resistance. PMID: 32715947 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Long-term results of Gamma Knife radiosurgery for facial nerve schwannomas.
CONCLUSIONS: Gamma Knife radiosurgery achieves excellent results with respect to tumor control for 7 years on average. In addition, Gamma Knife radiosurgery provides good results in facial nerve and hearing function at long term. Our series demonstrates that Gamma Knife radiosurgery is an effective and safe treatment for patients with either primary or residual facial nerve schwannoma. PMID: 32705956 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Mechanical properties of human glioma.
Authors: Tsitlakidis A, Aifantis EC, Kritis A, Tsingotjidou AS, Cheva A, Selviaridis P, Foroglou N Abstract Brain gliomas represent some of the most aggressive tumors encountered by modern medicine and, despite major efforts to optimize early diagnosis and treatment, the prognosis remains poor. Due to the complex structure of the brain and the unique mechanical properties of the extracellular matrix, gliomas invade and expand into the brain parenchyma, along white matter tracts and within perivascular spaces, usually sparing normal vessels. Different methods have been developed to study the mechanical properties of...
Source: Neurological Research - July 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Agitation after traumatic brain injury: a review of current and future concepts in diagnosis and management.
DISCUSSION: While much progress has been made in understanding post-traumatic agitation, there remain several key areas that require further elucidation to support the care and treatment for people with traumatic brain injury. PMID: 32706643 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Neurological complications of COVID-19: a systematic review.
CONCLUSIONS: Considering the possibility of neurological involvement in patients with SARS-CoV-2 infection can result in earlier diagnosis and treatment; otherwise permanent, irreversible sequelae and even death may follow. More comprehensive studies may indicate that until the end of the present pandemic, young adults with unexplained and unexpected stroke as well as patients with newly diagnosed Guillain-Barré syndrome should be tested for SARS-CoV-2 infection. PMID: 32698732 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Extracellular vesicles isolated from human olfactory ensheathing cells enhance the viability of neural progenitor cells.
DISCUSSION: Our findings reveal a role for hOEC-derived EVs in NPC proliferation and oxidative stress-induced neuronal toxicity model. These results may be useful for developing non-cell therapy OEC-EV-based treatment in acquired nervous system disease. PMID: 32700620 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Relationship between ischemic stroke locations, etiology subtypes, neurological outcomes, and autonomic cardiac function.
This study aimed to investigate the association between HRV and infarct locations, etiology subtypes, and neurological functional outcomes in patients with acute ischemic stroke (AIS). METHODS: In this prospective observational study, 186 consecutive patients were assigned to four major stroke severity categories based on the National Institutes of Health Stroke Scale score (NIHSS) and the modified Rankin Scale score (mRS): mild (NIHSS 0-4) stroke, moderate (NIHSS 5-14) stroke, 'favorable' (mRS 0-2) group, and 'unfavorable' (mRS 3-5) group. HRV time domain parameters were applied to evaluate the autonomic function of p...
Source: Neurological Research - July 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Accuracy of imaging markers on noncontrast computed tomography in predicting intracerebral hemorrhage expansion.
Conclusion The four NCCT markers can predict HE with limited sensitivity, high specificity and good accuracy. This may be useful for prompt identification of patients at high risk of active bleeding, and prevention of over-treatment associated with HE. Abbreviations HE, hematoma expansion; ICH, intracerebral hemorrhage; NCCT, noncontrast computed tomography. PMID: 32693733 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Cervical dystonia: factors deteriorating patient satisfaction of long-term treatment with botulinum toxin.
CONCLUSION: Cervical pain and coexistence of oromandibular dystonia deteriorated long-term treatment satisfaction in CD patients. Higher scores of Tsui and TWSTRS subscales were correlated with worse subjective BoNT treatment response. PMID: 32693754 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

AST to ALT ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke.
CONCLUSIONS: Higher AAR was associated with an increased risk of HT after ischemic stroke. In addition, AAR might be a better biomarker for predicting HT than ALT or AST. PMID: 32697140 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Surgical management and outcome of adult posterior cranial fossa and spinal hemangioblastoma: a 6-case series and literature review.
CONCLUSION: Surgical management of cerebellar and spinal cord hemangioblastoma in adults is highly dependent on its morphological features, as well as on microsurgical technique applied. Since huge differences exist between the cystic/nodular tumor type (Type 1) and the solid type and its two additional variants (Types 2-4), morphology is the most important consideration when deciding surgical approach. Despite significant morphological differences among different subtypes of hemangioblastomas, their histology appears to be relatively similar. Nonetheless, a meticulous and refined surgical technique has to be utilized to a...
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Changes in white matter microstructure related to non-linguistic cognitive impairment in post-stroke aphasia.
Authors: Yao J, Liu X, Lu X, Xu C, Chen H, Zhang Y Abstract OBJECTS: Post-stroke aphasia (PSA) often have non-linguistic cognitive impairment. We aimed to ascertain its characteristics of non-linguistic cognitive impairment and the corresponding changes in white matter microstructures. METHODS: Ten patients with PSA and 17 healthy controls (HCs) were enrolled. Loewenstein occupational therapy cognitive assessment (LOTCA) were used to assess non-linguistic cognitive function. Summary T-test was performed to compare the LOTCA scores between PSA and the Chinese norm. Tract-based spatial st...
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Downregulation of Thbs4 caused by neurogenic niche changes promotes neuronal regeneration after traumatic brain injury.
The objective of this study was to alter the neurogenic niche at the injured cortex and study its impact on neurogenesis. METHODS: We constructed a stromal cell-derived factor 1 (SDF-1) gradient matrix to attract reactive astrocytes to the glial scar core. RESULTS: SDF-1 reacted with the astrocytes in the injured site. By changing the neurogenic niche of the injured part of the brain after traumatic brain injury (TBI), SDF-1 downregulated thrombospondin 4 (Thbs4) promoting neuronal cell regeneration and playing a beneficial role in nerve function recovery after brain injury. DISCUSSION: The matrix we created in...
Source: Neurological Research - July 22, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats.
CONCLUSION: These findings highlight the worsening effects of treadmill exercise for migraine in rats with and without MD stress. However, inflammatory response can further exacerbate in stressed rats. PMID: 32686605 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 22, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Odontoid calcification and crowned dens syndrome: data from a Chinese center.
CONCLUSIONS: Odontoid calcification is a common radiological entity in patients older than 50 years. Lower Hgb, RBC, higher CRP, pain scale score were found in CDS patients comparing with non-CDS. PMID: 32657240 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Alexithymia is a non motornon-motor symptom of essential tremor regardless of the presence of depression and anxiety.
Authors: Sengul Y, Sengul HS, Gokcal E, Ustun I, Ozturk A, Yilmaz O, Yildiz GB, Louis ED Abstract OBJECTIVE: Essential tremor (ET) is one of the most common movement disorders. Aside from tremor, patients may exhibit other motor features as well as non-motor features, including neuropsychiatric symptoms. The cerebellum and cerebellar connections are thought to play a key role in the pathophysiology of ET. Cognitive and affective disturbances can occur in the context of cerebellar disease. Our aim was to study the prevalence and clinical correlates of alexithymia and its relationship to depression and anxi...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Arterial spin labeling-MR may be an alternative to SPECT for evaluating cerebral perfusion in patients with unilateral middle cerebral artery stenosis.
Authors: Ya J, Zhou D, Ding J, Rajah GB, Wu Y, Yang X, Hou Y, Jin K, Pan L, Wu Y, Du J, Ding Y, Ji X, Yang Q, Meng R Abstract OBJECTIVE: Cerebral blood flow (CBF) mapping of single-photon emission tomography (SPECT) is considered a gold standard for evaluating cerebral perfusion. However, invasiveness, high costs and strict technical requirements can limit its clinical use. We aimed to evaluate the concordance of CBF maps obtained from SPECT and pseudo-continuous arterial spin labeling magnetic resonance (PCASL-MR) imaging for evaluating cerebral perfusion. METHODS: PCASL-MR/SPECT-CBF maps were obtained from 16...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF- κB signaling pathway inhibition.
Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition. Neurol Res. 2020 Jul 13;:1-10 Authors: Fan X, Elkin K, Shi Y, Zhang Z, Cheng Y, Gu J, Liang J, Wang C, Ji X Abstract It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted from Schisandra chinensis, has been shown to ...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

In vivo evaluation of bilayer ORC/PCL composites in a rabbit model for using as a dural substitute.
This study aimed to assess the effectiveness and safety of new bilayer ORC/PCL composites in a rabbit model. METHODS: Two formulations of bilayer oxidized regenerated cellulose (ORC)/poly ε-caprolactone (PCL) knitted fabric-reinforced composites and an autologous graft (pericranium) were employed for dural closure in forty-five male rabbits. Systemic reaction and the local reaction of the samples were assessed and compared at one-, three- and six-months post-implantation by blood chemistry and gross, and microscopic assessment using hematoxylin-eosin and Masson's trichrome stains. RESULTS: No signs of CSF l...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Effect of renal function on association between uric acid and prognosis in acute ischemic stroke patients with elevated systolic blood pressure.
Authors: Zheng X, Wang A, Zhu Z, Peng Y, Peng H, Zhong C, Bu X, Guo D, Xu T, Chen J, Xu T, Ju Z, Geng D, Zhang Y, He J Abstract BACKGROUND AND AIMS: The prognostic value of uric acid in ischemic stroke remains controversial, and it is unclear whether renal function status modifies the prognostic value of uric acid in ischemic stroke patients. METHODS: A total of 3284 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) with creatinine and uric acid measurements were included in this analysis. The primary outcome was a composite of death and major disability (modi...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The Prevalence of Trigeminal Neuralgia in Turkey: A Population-Based Study.
This study establishes the prevalence of TN in Turkey for the first time. The prevalence rate is low when compared with other international studies. PMID: 32662754 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between the platelet to leukocyte ratio and mechanical thrombectomy outcomes in acute ischemic stroke patients.
This study aimed to investigate the prognostic value of PNR and PWR in acute ischemic stroke patients treated with EVT. METHODS: Poor functional outcome was defined as Modified Rankin Scale (mRS) of 3-6 at 3 months, Symptomatic intracranial hemorrhage (sICH) was diagnosed based on CT scan and classified according to the criterial of Heidelberg Bleeding Classification. Binary logistical regression was used to analyze the relationship of PWR, PNR with functional outcome and symptomatic intracranial hemorrhage (sICH). RESULTS: Patients with good prognosis had higher PNR and PWR value (29 vs. 24, P=0.002) (22 vs. 19, P...
Source: Neurological Research - July 11, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Tissue oxygenation indices of cerebrovascular autoregulation in healthy volunteers: a comparison of two NIRS devices.
Authors: Peng A, Chua MJ, Chan B, Jaeger M, Aneman A, Chuan A Abstract BACKGROUND: Correlation coefficients between blood pressure and cerebral oxygen saturation measured using near-infrared spectrometry may be used to derive the tissue oximetry index of cerebral autoregulation. Cerebral oxygen saturations demonstrate poor agreement between near-infrared spectrometers however it is unclear if measurements of autoregulation are similarly specific to the equipment used. METHODS: Cerebral oxygen saturation was monitored bilaterally in 74 healthy volunteers using both the FORE-SIGHT and EQUANOX monitors in random o...
Source: Neurological Research - July 11, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Apolipoprotein E polymorphism carriers exhibit objective cognitive deficits: a single center trial.
Authors: Zeng Y, Huang X, Elkin K, Stone C, Rajah GB, Guan L, Du H, Geng X Abstract OBJECTIVE: To assess the correlation between objectively measured cognitive function and apolipoprotein E polymorphism within one geographic region. METHODS: 61 patients, aged 55-90 years old, were enrolled in a memory clinic at the Beijing Luhe Hospital affiliated with Capital Medical University from September 2016 to September 2018. At this center, they were evaluated with neuropsychological scales to assess their memory and other aspects of cognitive function. Specific gene segments were extracted from venous blood by PCR amp...
Source: Neurological Research - July 9, 2020 Category: Neurology Tags: Neurol Res Source Type: research

SLC2A3 rs12842 polymorphism and risk for Alzheimer's disease.
CONCLUSIONS: Our results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD. PMID: 32627711 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Administration of Vitamin D3 and E supplements reduces neuronal loss ‏ and oxidative stress in a model of rats with Alzheimer's disease.
Conclusion: The present study indicated that vitamin D3 and E and their combination can improve memory and learning deficit, and decrease neuronal loss and oxidative stress in Alzheimer's model. PMID: 32627720 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Conditional entropy approach to analyze cognitive dynamics in autism spectrum disorder.
DISCUSSION: The statistical results reflect a significant change in the information flow between different ROIs in ASD. A correlation of CS and behavioral domain suggests that the cognitive decline could be predicted from the connectivity patterns. Thus, CS could be a potential biomarker to identify cognitive status at a higher discrimination rate in ASD. PMID: 32628095 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Late changes in blood-brain barrier permeability in a rat tMCAO model of stroke detected by gadolinium-enhanced MRI.
Authors: Morgan CA, Mesquita M, Ashioti M, Beech JS, Williams SCR, Irving E, Cash D Abstract OBJECTIVES: After cerebral ischaemia the blood-brain barrier (BBB) may be compromised and this has been observed in both clinical and preclinical studies. The timing of BBB disruption after ischaemia has long been considered to be biphasic, however some groups contest this view. Therefore, the purpose of this study was to characterize the BBB permeability timecourse in a rat model at both acute and chronic time points. METHODS: Unilateral transient middle cerebral artery occlusion (tMCAO) was performed in 15 male Spragu...
Source: Neurological Research - July 2, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Is fusion the most suitable treatment option for recurrent lumbar disc herniation? A systematic review.
CONCLUSION: There is significant heterogeneity in clinical outcomes reported for studies after surgical intervention in rLDH patients. Neither discectomy nor fusion's superiority was statistically significant. Despite fusion yielding longer operative times, and length of stay (adding to the expense), it is superior in minimising mechanical instability and recurrence. Finally, we conclude that both approaches are equally efficacious in rLDH cases, and choice should be based on a case by case basis. PMID: 32602420 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 2, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Safely performing neurosurgical procedures during COVID-19 pandemic.
CONCLUSION: Following the proposed guidance, urgent neurosurgical surgeries and procedures can be safely performed for the benefit of critical patients with or suspected for COVID-19. PMID: 32608340 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - July 2, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia.
CONCLUSION: LGSL promoted focal angiogenesis and attenuated ischemia-induced brain injury, suggesting that LGSL is a potential agent that improves angiogenesis and promotes recovery from ischemic stroke. PMID: 32584207 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - June 27, 2020 Category: Neurology Tags: Neurol Res Source Type: research