Structural and cognitive correlates of fatigue in progressive multiple sclerosis.
CONCLUSION: In this exploratory study of patients with progressive MS, fatigue was related to processing speed. Motor fatigue was also related to the cortical thickness of the primary motor cortex and there was a trend towards a relationship between cognitive fatigue and the thickness of cortical areas involved in attentional processes. Additional studies are needed to further elucidate the relationship between regional cortical atrophy, cognitive functioning and the perception of fatigue. ABBREVIATIONS: FSMC: Motor and Cognitive Functions; MS: Multiple Sclerosis; SDMT: Symbol Digit Modalities Test; MRI: Magnetic Reson...
Source: Neurological Research - December 6, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Both thapsigargin- and tunicamycin-induced endoplasmic reticulum stress increases expression of Hrd1 in IRE1-dependent fashion.
DISCUSSION: Thus, the ER-stress-induced expression of Hrd1 in SH-SY5Y depends on Hrd1 transcription activation, which is a consequence of IRE1 but not of PERK activation. PMID: 30475171 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Early microalbuminuria as a clinical marker for acute cerebral small vessel infarction.
Authors: Zhai Z, Feng J Abstract BACKGROUND: Previous studies have shown the potential interactions between cerebrovascular diseases and microalbuminuria. However, the relationship between urine microalbumin and acute lacunar infarction caused by cerebral small vessel disease (CSVD) remains unknown. METHODS: The clinical data of 148 patients with acute lacunar infarction admitted to the Department of Neurology, Shengjing Hospital of China Medical University between April 2016 and April 2017 were analyzed. They were divided into either a CSVD group (n = 70) or a cerebral large vessel disease (CLVD) group (n...
Source: Neurological Research - November 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Factors related to excessive sleepiness in patients with Parkinson's disease.
CONCLUSION: PD patients present a high prevalence of ES, and some factors, different from those observed in the general population, seem to have a greater impact in this group of patients. ABBREVIATIONS: RLS/ WED: Restless legs syndrome; Willis-Eckbom Disease ES: Excessive sleepiness. PMID: 30462589 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 23, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Active caspase-3 upregulation is augmented in at-risk cerebellar Purkinje cells following inferior olive chemoablation in the shaker mutant rat: an immunofluorescence study.
DISCUSSION: Consequently, it can be deduced that active caspase-3 expression in shaker mutant rats is modifiable suggesting the possibility of targeting it therapeutically in an attempt to rescue PCs from death. Abbreviation PC: Purkinje cell; IO: inferior olive; ADC: Anterior degeneration compartment; PDC: Posterior degeneration compartment; ISC: Intermediate survival compartment; FNSC: Flocculonodular survival compartment. PMID: 30462592 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 23, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Forced FoxO1:S249V expression suppressed glioma cell proliferation through G2/M cell cycle arrests and increased apoptosis.
CONCLUSION: Our findings suggest that the forced FoxO1:S249V suppressed the cell growth through G2/M cell cycle arrests and increased apoptosis in glioma. PMID: 30453847 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 22, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Time-dependent effect of oligomeric amyloid- β (1-42)-induced hippocampal neurodegeneration in rat model of Alzheimer's disease.
CONCLUSION: Acute exposure of oAβ1-42 modulated differential gene expression of glutamatergic and cholinergic receptors in hippocampus of adult rats and is duration dependent reflecting changes in hippocampal circuitry system underlying learning and memory impairments. ABBREVIATIONS: AD: Alzheimer's disease, Aβ: amyloid-β; oAβ1-42: oligomeric amyloid-β 1-42 full length peptide; CAM: calmodulin; CNS: central nervous system; CR: Congo red; DG: dentate gyrus; EC: entorhinal cortex; HFIP: 1,1,1,3,3,3-hexafluoro-2-propanol; IBO: ibotenic acid; N...
Source: Neurological Research - November 22, 2018 Category: Neurology Tags: Neurol Res Source Type: research

A novel cognitive-behavioral stress management method for multiple sclerosis. A brief report of an observational study.
DISCUSSION: PSAI can benefit cognitive function and psychological distress in MS patients. Future studies should expand these results in randomized trials and by using longer follow-up and MS activity-related endpoints. ABBREVIATIONS: BICAMS: Brief International Cognitive Assessment for Multiple Sclerosis BVMT-R: Brief Visuospatial Memory Test Revised CVLT: California Verbal Learning Test DASS: Depression Anxiety Stress Scale EDSS: Expanded Disability Status Scale MS: Multiple Sclerosis NNT: Numbers Needed to Treat PS: Propensity Score PSAI: Pythagorean Self-Awareness Intervention RR: Relapsing Remitting SDMT: Symbol D...
Source: Neurological Research - November 20, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Serum leptin is associated with first-ever ischemic stroke, lesion size and stroke severity in a Chinese cohort.
Authors: Liu G, Dong M, Ma S, Fu L, Xiao Y, Zhong L, Geng J Abstract OBJECTIVE: Leptin may be associated with cardiovascular disease. We tested to determine whether leptin is a marker for first-ever acute ischemic stroke (AIS) in a nested case-referent study. METHODS: Consecutive patients with first-ever AIS from May 2017 to December 2017 were included. Referents were matched for sex, age and body mass index. Serum leptin levels and routine tests were examined in both groups. RESULTS: The median serum level of leptin in the stroke patients was 14.3 (interquartile range [IQR], 7.2-21.7) ng/ml, which was significantly higher (P
Source: Neurological Research - November 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Reversed ophthalmic artery flow following ischemic stroke: a possible predictor of outcomes following carotid artery stenting.
This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group. PMID: 30433861 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Analysis of biochemical laboratory values to determine etiology and prognosis in patients with subarachnoid hemorrhage: a clinical study.
CONCLUSION: NLR, PLR and eosinophil count values could be predictive for etiological factors (traumatic SAH or spontaneous SAH) of patients who were admitted unconscious to the emergency room with SAH detected on radiological imaging. PMID: 30417744 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
CONCLUSION: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding. PMID: 30417762 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy.
DISCUSSION: Several MRI-derived parameters can be used in differentiation of patients with PSP from patients with PD, MSA and control subjects. The cerebral interpeduncular angle and MRPI, which demonstrated higher values in patients with PSP, were more significant for PSP than the other parameters. PMID: 30373485 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Influence of mTOR signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats.
CONCLUSION: Inhibition of mTOR signaling pathway protected rat hippocampal neurons from ketamine-induced injuries via reducing apoptosis, oxidative stress, as well as Ca2+ concentration. ABBREVIATIONS: mTOR: mammalian target of rapamycin; SD: Sprague-Dawley; SPF: Specific-pathogen free; ROS: reactive oxygen species; TUNEL: terminal transferase uridyl nick end labelling; DCFH-DA: Dichloro-dihydro-fluorescein diacetate; Fluo-3A: Fluo-3 acetoxymethyl ester; NMDAR: non-competitive N-methyl-D-aspartame glutamate receptor; 4E-BP1: 4E binding protein 1; p70S6K: p70 S6 Kinase; PCR: Polymerase chain reaction; MDA: malonildialde...
Source: Neurological Research - October 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Hereditary and idiopathic spastic paraparesis: preliminary findings of a single center experience.
We reported the clinical features of HSP from 56 patients in our hospital. Our findings should be helpful for better understanding of clinical features of HSP. PMID: 30352018 [PubMed - in process] (Source: Neurological Research)
Source: Neurological Research - October 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis.
CONCLUSION: The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Han and Hui nationalities. PMID: 30352019 [PubMed - in process] (Source: Neurological Research)
Source: Neurological Research - October 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel.
Authors: Zhang X, Jiang N, Li J, Zhang D, Lv X Abstract BACKGROUND/AIMS: Paclitaxel is largely used as a chemotherapeutic agent for the treatment of several types of cancers. However, one of the significant limiting complications of paclitaxel is painful peripheral neuropathy during its therapy. The purposes of this study were to examine (1) the effects of blocking mammalian target of rapamycin (mTOR) on mechanical and thermal hypersensitivity evoked by paclitaxel; and (2) the underlying mechanisms responsible for the role of mTOR in regulating paclitaxel-induced neuropathic pain. METHODS: Behavioral test was p...
Source: Neurological Research - October 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Seizure forecasting using single robust linear feature as correlation vector of seizure-like events in brain slices preparation in vitro.
Conclusion: It is worth mentioning that the proposed study utilized a single linear feature to predict seizures precisely. Moreover, utilization of single feature encouraged in subsiding system complexity, processing delays, and system latency. PMID: 30332347 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

D-dimer > 2.785  μg/ml and multiple infarcts ≥3 vascular territories are two characteristics of identifying cancer-associated ischemic stroke patients.
CONCLUSIONS: D-dimer>2.785 μg/ml may be an effective cutoff value and a sensitive index for identifying CAIS patients. AMBIs in ≥3 vascular territories and AMBIs in both the anterior and posterior circulations are two imaging characteristics of CAIS. PMID: 30317943 [PubMed - in process] (Source: Neurological Research)
Source: Neurological Research - October 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Diabetes mellitus inhibits complete recanalization in patients with middle cerebral artery occlusion.
CONCLUSION: Diabetes might be a risk factor of incomplete recanalization at 24 h regardless of early recanalization. PMID: 30319049 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Correction.
Authors: PMID: 30311854 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Landscape of pain in Parkinson's disease: impact of gender differences.
Authors: Zella MAS, May C, Müller T, Ahrens M, Tönges L, Gold R, Marcus K, Woitalla D Abstract BACKGROUND/AIMS: Pain is a non-motor symptom of Parkinson's disease (PD). Few systematic studies have been carried out and there are still no guidelines on pain therapy in PD. Additionally, within the studies that do exist, gender-specific differences in pain perception are often the focus, though no consistent results have to date been obtained. The first main aim of our study was therefore to map pain in the largest PD study group to date, with the second being the analysis of the impact of different pain ther...
Source: Neurological Research - October 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Keyhole approaches for surgical treatment of intracranial aneurysms: a short review.
Authors: Rychen J, Croci D, Roethlisberger M, Nossek E, Potts MB, Radovanovic I, Riina HA, Mariani L, Guzman R, Zumofen DW Abstract OBJECTIVE: To clarify the reported experience with keyhole approaches for the treatment of intracranial aneurysms. METHODS: The PubMed and Embase databases were searched up to December 2017 for full-text publications that report the treatment of aneurysms with the eyebrow variant of the supraorbital craniotomy (SOC), the minipterional craniotomy, or the eyelid variant of the SOC. The anatomical distribution of aneurysms, the postoperative aneurysm occlusion rate, and the type and r...
Source: Neurological Research - October 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Clinical differences of early and late-onset myasthenia gravis in 985 patients.
Authors: Fan L, Ma S, Yang Y, Yan Z, Li J, Li Z Abstract OBJECTIVE: The clinical differences of early-onset myasthenia gravis (EOMG) and late-onset MG (LOMG) have not been elucidated in China. In order to clarify this, a retrospective study was conducted in 985 MG patients, whose disease duration was longer than 3 years. METHODS: These patients were separated into EOMG and LOMG according to the onset age of 50 years. The clinical differences including demographics, clinical features, thymus abnormalities and comorbidities of EOMG and LOMG patients were analyzed. RESULTS: Results indicated that 485...
Source: Neurological Research - October 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Effect of regular swimming exercise to duration-intensity on neurocognitive function in cerebral infarction rat model.
CONCLUSIONS: Regular swimming exercise of moderate duration-intensity may be the most effective exercise protocol for the recovery of neurocognitive function in cerebral infarction rat model. PMID: 30311868 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Lp-PLA2 as a risk factor of early neurological deterioration in acute ischemic stroke with TOAST type of large arterial atherosclerosis.
Authors: Wang Y, Hu S, Ren L, Lei Z, Lan T, Cai J, Li C Abstract INTRODUCTION: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well-known risk factor of atherosclerotic vascular diseases. Nevertheless, its role in the acute phase of ischemic stroke is still unclear. The aim of this study is to identify the relationship between Lp-PLA2 levels and early neurological deterioration (END) in acute ischemic stroke patients with Trial of Org 10 172 in Acute Stroke Treatment (TOAST) subtype of large arterial atherosclerosis (LAA). METHODS: We enrolled Chinese patients with first ever acute ischemic stroke admitt...
Source: Neurological Research - October 10, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Mir-206 partially rescues myogenesis deficiency by inhibiting CUGBP1 accumulation in the cell models of myotonic dystrophy.
CONCLUSIONS: Ectopic miR-206 mimicking the endogenous temporal patterns specifically drives a myocyte program that boosts myoblast lineages, likely by promoting the expression of MyoD to rectify the myogenic deficiency by stimulating the accumulation of Celf1. ABBREVIATIONS: DMPK: (dystrophia myotonica protein kinase); 3'-UTR: (3'-untranslated region); MBNL1: (muscleblind-like [Drosophila]); DM1: (myotonic dystrophy type 1); GFP: (green fluorescent protein); RT-PCR: (quantitative reverse transcriptase-polymerase chain reaction); shRNA: (short hairpin RNA). PMID: 30281408 [PubMed - as supplied by publisher] (Source:...
Source: Neurological Research - October 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The changes of systemic immune responses during the neuroprotection induced by remote ischemic postconditioning against focal cerebral ischemia in mice.
CONCLUSIONS: The present study indicates that there were significant changes of inflammatory responses during the neuroprotection induced by RIPostC in stroke mice. PMID: 30281410 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Osteopontin is indispensable for activation of astrocytes in injured mouse brain and primary culture.
DISCUSSION: Our data suggest that OPN is essential for proper astrocytic generation in vitro culture prepared from mouse cerebral cortex. OPN is indispensable for astrocyte activation in the mouse brain injury model and in LPS stimulated primary culture. ABBREVIATIONS: AQP4: aquaporin 4; BBB: blood brain barrier; BrdU: bromo-deoxy uridine; CNS: central nervous system; GFAP: glial fibllirary acidic protein; IgG: immunoglobulin G; LPS: lipopolysaccharide; OPN: osteopontin; OPN/KO: osteopontin-deficient; TN-C: tenascin-C. PMID: 30246619 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of dexamethasone treated mesenchymal stem cells for recovery in neurotmesis model of peripheral nerve injury.
DISCUSSION: Taken together, use of DEX associated with cell and biodegradable membrane could improve functional and histomorphological properties of the sciatic nerve after injury. PMID: 30246623 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Intravascular imaging in neuroendovascular surgery: a brief review.
Authors: Saber H, Rajah GB, Seraji-Bozorgzad N, Nasiriavanaki M Abstract Intravascular imaging has significantly contributed to the advancement of interventional cardiology. Intravascular ultrasound and optical coherence tomography have facilitated decision-making and interventional strategies in management of coronary artery lesions. Yet, applications of these modalities are limited in cerebrovascular practice. With the momentum in advancement of neuroendovascular interventions and techniques for treatment of strokes, cerebrovascular atherosclerotic diseases, aneurysms and vascular malformations, there is a need f...
Source: Neurological Research - September 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Negative impact of severity of pain on mood, social life and general activity in Parkinson's disease.
Authors: Rana AQ, Qureshi ARM, Haris A, Danish MA, Furqan MS, Shaikh O, Sarfraz Z, Rana R Abstract OBJECTIVE: Pain is an important non-motor symptom of Parkinson's disease (PD); however, it remains understudied. The purpose of previous studies on the relationship between PD and pain, has been to explore the cause, origin and types of pain. This case control study is designed for clinicians and rehabilitation specialists to effectively identify pain from the patient's point of view. Pain present in PD patients correlates with significant disruption to their daily lives, which was seen by analysing characteristics, f...
Source: Neurological Research - September 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

A dopamine D1 receptor agonist improved learning and memory in morphine-treated rats.
CONCLUSION: (1) The PAG is involved in the learning and memory changes of the addicted rats; (2) the activation of DA D1 receptor will increase the GAD67, reduce the damage to peripheral neurons, and improve the learning and memory of the addicted rats; and (3) D1 receptor agonists further reduced TrkB expression in morphine-addicted rats, whereas TrkB levels deviated from changes in rat behavior. PMID: 30222083 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Excessive release of endogenous neuropeptide Y into cerebrospinal fluid after treatment of spontaneous subarachnoid haemorrhage and its possible impact on self-reported neuropsychological performance - results of a prospective clinical pilot study on good-grade patients.
DISCUSSION: To the best of our knowledge, this study is the first to correlate the levels of endogenous NPY in supratentorial CSF with cognitive outcome in good-grade sSAH patients. Excessive NPY release into CSF may have a short-term influence on the pathogenesis of neuropsychological deficits. The impact of cerebrovascular manipulation on NPY release has to be further elucidated. ABBREVIATIONS: ANOVA: analysis of variance; aSAH: aneurysmal subarachnoid haemorrhage; AUC: area under the curve; CBF: cerebral blood flow; CSF: cerebrospinal fluid; CT (scan): computed tomography (scan); CV: cerebral vasospasm; DIND: delaye...
Source: Neurological Research - September 15, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective ability of TMV coat protein on rat PC-12 cells and it's in silico study with LRRK2 receptor.
CONCLUSION: From the present study, it was found that TMV coat protein can be utilized as neuroprotective agent and inhibitor of LRRK2 receptor. PMID: 30213244 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 15, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Developmental abnormalities of the brain exposed to childhood maltreatment detected by diffusion tensor imaging.
This study aimed to investigate brain developmental alterations in individuals exposed to childhood maltreatment (CM) with dissociative experiences and motor coordination symptoms using diffusion tensor imaging on a 3Tesla (3T) magnetic resonance (MR) system. METHODS: Five individuals exposed to CM who manifest behavioral and developmental problems with dissociative experiences and motor coordination symptoms (age range: 14-18 years; all female), as well as seven age- and gender-matched normal control individuals, participated in the study using a 3T MR system. Diffusion characteristics, as indexed by fractional a...
Source: Neurological Research - September 15, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
CONCLUSION: Pathogenesis of AF is involved abnormal changes of hemostasis, endothelial dysfunction, antithrombotic state and inflammation. The homeostatic markers, which play role in these pathways, and the presence of BMBs could use to form a prognostic clinic assessment tool to predict bleeding risk. PMID: 30207930 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study.
CONCLUSIONS: Parenchymal contusions in MTBI are often accompanied by extraaxial hemorrhage. TCs may be associated with 6-month functional impairment. Their presence on imaging should alert the clinician to the need for heightened surveillance of sequelae complicating RTBWC, with low threshold for referral to services. PMID: 30175944 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Epilepsy classification using optimized artificial neural network.
In this study, EEG datasets for epilepsy disease detection were taken from a public domain (Bonn University, Germany). These EEG recordings contain 100 single-channel EEG signals with maximum duration of 23.6 seconds. This data set was recorded intra-cranially and extra-cranially with the help of a 128-channel amplifier system using a common reference point. RESULTS: For a unique set of EEG signal features, the Optimized Artificial Neural Network model for classification and validation was developed with optimum neurons in the hidden layer. Results were tested on the basis of accuracy, sensitivity, precision, and speci...
Source: Neurological Research - August 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Resveratrol attenuates brain damage in permanent focal cerebral ischemia via activation of PI3K/Akt signaling pathway in rats.
CONCLUSION: RSV attenuated ischemic brain damage induced by cerebral artery occlusion mainly through PI3K/Akt signaling pathway. Abbreviation: MCAO: Middle cerebral artery occlusion; RSV: resveratrol; PI3K/Akt: phosphatidylinositol 3-kinase/Akt; TNF: tumor necrosis factor; COX2: cyclooxygenase-2; MPO: myeloperoxidase; IL: interleukin. PMID: 30156477 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Influence of hemodynamics on enlarged perivascular spaces in atherosclerotic large vessel disease.
CONCLUSIONS: The number of EPVS was increased in patients with atherosclerotic large vessel disease with hemodynamic compromise and decreased in the presence of a large stroke. EPVS might act as fluid absorbers in a hemodynamically compromised state until the occurrence of an ischemic stroke. PMID: 30156508 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Predictors of mortality and recurrent stroke within five years of intracerebral hemorrhage.
Conclusion Predictors of recurrent stroke were older females, hypertension, diabetes, and brain stem hemorrhage. These findings may help to determine specific treatment strategies and improve quality of health care for such patients. PMID: 30134784 [PubMed - in process] (Source: Neurological Research)
Source: Neurological Research - August 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
In this study, we aim to reveal the alterations (due to seizure) in the serum and brain levels of nesfatin-1, ghrelin and irisin after acute or chronic pentylenetetrazole administrations in rats using sodium valproate. METHODS: 35 Wistar albino rats were randomly divided into five groups: Control, Acute Pentylenetetrazole group (APTZ), Acute Pentylenetetrazole+ Valproate group (AVPA), PTZ kindling group (PTZk) and PTZ kindling+ Valproate group (KVPA). Serum and brain levels of ghrelin, nesfatin-1 and FNDC5/irisin were determined with ELISA. RESULTS: Serum levels of ghrelin were significantly decreased in ...
Source: Neurological Research - August 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Percutaneous mastoid electrical stimulator alleviates autonomic dysfunction in patients with acute ischemic stroke.
CONCLUSIONS: PMES was a safe, effective, and low-cost therapy to alleviate HRV and could significantly reduce mortality in the early recovery phase after acute ischemic stroke. PMID: 30111262 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Kinematic patterns for hindlimb obstacle avoidance during sheep locomotion.
This study aims to get kinematic data to serve as a template for an objective assessment of the ankle joint motion in future studies of common peroneal nerve (CP) injury and repair in the ovine model. Our results show that a moderately high obstacle set to 10% of the sheep's hindlimb length was associated to several spatial and temporal strategies in order to increase hoof height during obstacle negotiating. Sheep efficiently cleared an obstacle by increasing knee, ankle and metatarsophalangeal flexion during swing, whereas the hip joint is not affected. This study establishes the bounds of normal motion in the neurologica...
Source: Neurological Research - August 15, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Thymoquinone protects DRG neurons from axotomy-induced cell death.
CONCLUSION: TQ exhibits a regenerative potential for the treatment of damaged peripheral nerves. PMID: 30088803 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 11, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Effect of swimming training on nerve morphological recovery after compressive injury.
This study aims to investigate morphological alterations caused by partial sciatic nerve ligation (PNL) and the efficacy of a moderate-intensity swimming training as therapeutic strategy for nerve regeneration. METHODS: A number of 30 male adult mice were equally divided in control, 14 days after PNL (PNL 14 days), 42 days after PNL (PNL 42 days), 70 days after PNL (PNL 70 days) and 5-week exercise training after 7 days post-lesion (PNL trained 35 days) groups. PNL trained 35 days group began with a 10-min session for 3 days and this time was gradually increased by 10&n...
Source: Neurological Research - August 11, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Activation of TRPV1 receptors affects memory function and hippocampal TRPV1 and CREB mRNA expression in a rat model of biliary cirrhosis.
This study set out to determine whether activation of transient receptor potential vanilloid type 1 (TRPV1) in the CA1 area of the hippocampus in rats improve memory impairment induced by biliary cirrhosis. METHODS: To assess learning and memory, passive avoidance task was carried out using a shuttle box. The mRNA expression of TRPV1 and cAMP response element binding (CREB) protein in the hippocampus were also evaluated by qT-PCR. RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocam...
Source: Neurological Research - August 8, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Identification of key target genes and biological pathways in multiple sclerosis brains using microarray data obtained from the Gene Expression Omnibus database.
CONCLUSION: Several key target genes and their GO and KEGG pathway enrichment identified in the present study may serve as feasible targets for MS therapies. PMID: 30074468 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - August 5, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Preoperative neutrophil-lymphocyte ratio correlated with glioma grading and glioblastoma survival.
This study aimed to investigate the relationship between preoperative NLR and glioma grading and also the correlation between NLR and glioblastoma survival. METHODS: The preoperative NLR was analyzed retrospectively in 239 gliomas of different grades, and receiver operating characteristic (ROC) curve analysis was adopted to investigate the prediction of glioma grading. Univariate and multivariate analyses were performed to analyze the variables of overall survival (OS) of glioblastoma patients. RESULTS: There were significant differences in the preoperative NLR values among the four glioma groups, with the highest ...
Source: Neurological Research - August 5, 2018 Category: Neurology Tags: Neurol Res Source Type: research