Calcium-independent phospholipase A2 inhibitor produces an analgesic effect in a rat model of neuropathic pain by reducing central sensitization in the dorsal horn
DISCUSSION: These data suggest that selective iPLA2 inhibitor produce analgesia in neuropathic rats by reducing central sensitization in the dorsal horn.PMID:33866950 | DOI:10.1080/01616412.2021.1915079 (Source: Neurological Research)
Source: Neurological Research - April 19, 2021 Category: Neurology Authors: Young Seob Gwak Guanxing Chen Salahadin Abdi Hee Kee Kim Source Type: research

Myelopathy associated with SARS-COV-2 infection. A systematic review
Conclusions׃ Considering the imminent arrival of new vaccines against COVID-19 pandemic, and their potential risk for postvaccination transverse myelitis, this characterization of COVID-19 related myelopathy is of utmost importance.PMID:33870878 | DOI:10.1080/01616412.2021.1915078 (Source: Neurological Research)
Source: Neurological Research - April 19, 2021 Category: Neurology Authors: Artemios Artemiadis Andreas Liampas Loizos Hadjigeorgiou Panagiotis Zis Source Type: research

Calcium-independent phospholipase A2 inhibitor produces an analgesic effect in a rat model of neuropathic pain by reducing central sensitization in the dorsal horn
DISCUSSION: These data suggest that selective iPLA2 inhibitor produce analgesia in neuropathic rats by reducing central sensitization in the dorsal horn.PMID:33866950 | DOI:10.1080/01616412.2021.1915079 (Source: Neurological Research)
Source: Neurological Research - April 19, 2021 Category: Neurology Authors: Young Seob Gwak Guanxing Chen Salahadin Abdi Hee Kee Kim Source Type: research

Myelopathy associated with SARS-COV-2 infection. A systematic review
Conclusions׃ Considering the imminent arrival of new vaccines against COVID-19 pandemic, and their potential risk for postvaccination transverse myelitis, this characterization of COVID-19 related myelopathy is of utmost importance.PMID:33870878 | DOI:10.1080/01616412.2021.1915078 (Source: Neurological Research)
Source: Neurological Research - April 19, 2021 Category: Neurology Authors: Artemios Artemiadis Andreas Liampas Loizos Hadjigeorgiou Panagiotis Zis Source Type: research

Reduced regulatory T lymphocytes in migraine patients
Conclusions: In this study, the number of Treg cells significantly decreased in new cases of migraine, which suggests that migraine is a result of an impairment in the immunological system or an autoimmune disease. Also, the insignificant difference in the number of Treg cells between the two categories of migraine suggests that there is no link between the reduced number of Treg cells and the emergence of aura symptoms or duration of the disease.PMID:33853506 | DOI:10.1080/01616412.2021.1915077 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Fardin Faraji Mana Shojapour Iman Farahani Ali Ganji Ghasem Mosayebi Source Type: research

Blink reflex monitoring in microvascular decompression for trigeminal neuralgia
Conclusions: Conclusion: The blink reflex may allow monitoring of trigeminal sensory function during microvascular decompression under general anesthesia.PMID:33853513 | DOI:10.1080/01616412.2021.1900705 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Tingting Ying Bei Bao Yan Yuan Wenxiang Zhong Jin Zhu Yinda Tang Shiting Li Source Type: research

Reduced regulatory T lymphocytes in migraine patients
Conclusions: In this study, the number of Treg cells significantly decreased in new cases of migraine, which suggests that migraine is a result of an impairment in the immunological system or an autoimmune disease. Also, the insignificant difference in the number of Treg cells between the two categories of migraine suggests that there is no link between the reduced number of Treg cells and the emergence of aura symptoms or duration of the disease.PMID:33853506 | DOI:10.1080/01616412.2021.1915077 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Fardin Faraji Mana Shojapour Iman Farahani Ali Ganji Ghasem Mosayebi Source Type: research

Blink reflex monitoring in microvascular decompression for trigeminal neuralgia
Conclusions: Conclusion: The blink reflex may allow monitoring of trigeminal sensory function during microvascular decompression under general anesthesia.PMID:33853513 | DOI:10.1080/01616412.2021.1900705 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Tingting Ying Bei Bao Yan Yuan Wenxiang Zhong Jin Zhu Yinda Tang Shiting Li Source Type: research

Reduced regulatory T lymphocytes in migraine patients
Conclusions: In this study, the number of Treg cells significantly decreased in new cases of migraine, which suggests that migraine is a result of an impairment in the immunological system or an autoimmune disease. Also, the insignificant difference in the number of Treg cells between the two categories of migraine suggests that there is no link between the reduced number of Treg cells and the emergence of aura symptoms or duration of the disease.PMID:33853506 | DOI:10.1080/01616412.2021.1915077 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Fardin Faraji Mana Shojapour Iman Farahani Ali Ganji Ghasem Mosayebi Source Type: research

Blink reflex monitoring in microvascular decompression for trigeminal neuralgia
Conclusions: Conclusion: The blink reflex may allow monitoring of trigeminal sensory function during microvascular decompression under general anesthesia.PMID:33853513 | DOI:10.1080/01616412.2021.1900705 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Tingting Ying Bei Bao Yan Yuan Wenxiang Zhong Jin Zhu Yinda Tang Shiting Li Source Type: research

Reduced regulatory T lymphocytes in migraine patients
Conclusions: In this study, the number of Treg cells significantly decreased in new cases of migraine, which suggests that migraine is a result of an impairment in the immunological system or an autoimmune disease. Also, the insignificant difference in the number of Treg cells between the two categories of migraine suggests that there is no link between the reduced number of Treg cells and the emergence of aura symptoms or duration of the disease.PMID:33853506 | DOI:10.1080/01616412.2021.1915077 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Fardin Faraji Mana Shojapour Iman Farahani Ali Ganji Ghasem Mosayebi Source Type: research

Blink reflex monitoring in microvascular decompression for trigeminal neuralgia
Conclusions: Conclusion: The blink reflex may allow monitoring of trigeminal sensory function during microvascular decompression under general anesthesia.PMID:33853513 | DOI:10.1080/01616412.2021.1900705 (Source: Neurological Research)
Source: Neurological Research - April 15, 2021 Category: Neurology Authors: Tingting Ying Bei Bao Yan Yuan Wenxiang Zhong Jin Zhu Yinda Tang Shiting Li Source Type: research

Effect of rt-PA intravenous thrombolysis on the prognosis of patients with minor ischemic stroke
This study aims to investigate the effect of rt-PA intravenous thrombolysis on the prognosis of patients with MIS.Methods:We continuously enrolled and analyzed patients with MIS admitted into our hospital within 24 h after symptom onset between January 2016 and December 2018, including 96 patients received intravenous thrombolysis within 4.5 h after symptom onset and 84 patients not received intravenous thrombolysis. A favorable long-term outcome was a 90-day mRS score of 0-1. Good short-term outcome was a 7-day NIHSS score of 0 or less than NIHSS onset.Results: There were no statistical differences between two groups of p...
Source: Neurological Research - April 13, 2021 Category: Neurology Authors: Yingying Han Gang Li Yueyu Tang Bei Zhang Yiqiang Zhan Chunfang Zhang Lian Zuo Wei Wu Source Type: research

Chlorpromazine and promethazine reduces Brain injury through RIP1-RIP3 regulated activation of NLRP3 inflammasome following ischemic stroke
Conclusion: These findings suggest that the anti-inflammatory effect of C + P may be dependent on drug-induced hypothermia and regulation of the NLRP3 inflammasome via the RIP1/RIP3 complex. Future investigations are needed regarding C + P as potential treatment of ischemic stroke.PMID:33829970 | DOI:10.1080/01616412.2021.1910904 (Source: Neurological Research)
Source: Neurological Research - April 8, 2021 Category: Neurology Authors: Qian Jiang M élissa Wills Xiaokun Geng Yuchuan Ding Source Type: research

Microstructural changes in the cingulate gyrus of patients with mild cognitive impairment induced by cerebral small vessel disease
Neurol Res. 2021 Apr 7:1-9. doi: 10.1080/01616412.2021.1910903. Online ahead of print.ABSTRACTObjective: The purpose of our study was to distinguish the changes in the microstructure of the cingulate cortex in patients with mild cognitive impairment (MCI) induced by cerebral small vessel disease (CSVD).Method: 80 patients were diagnosed with CSVD in this study, including 55 patients with MCI and 25 patients without MCI. Diffusion kurtosis imaging (DKI) and Montreal cognitive assessment (MoCA) were performed in all patients. The anterior cingulate gyrus, posterior cingulate gyrus and middle cingulate gyrus were selected as ...
Source: Neurological Research - April 7, 2021 Category: Neurology Authors: Huilin Liu Dongtao Liu Kun Li Xiaofan Xue Xiangke Ma Qiao Bu Jing Ma Zhenyu Pan Lichun Zhou Source Type: research

A risk prediction model of post-stroke cognitive impairment based on magnetic resonance spectroscopy imaging
Discussion: A PSCI risk prediction model based on MRS serves to assist clinicians in estimating the risk of cognitive impairment after stroke.PMID:33784942 | DOI:10.1080/01616412.2021.1908659 (Source: Neurological Research)
Source: Neurological Research - March 31, 2021 Category: Neurology Authors: Xueling Yuan Lei Zhang Rubo Sui Zhuo Wang Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF- κB signaling pathway in mice
CONCLUSION: Rifampicin protects against LPS-induced neuroinflammation and attenuates cognitive and motor impairments by inhibiting the TLR4/MyD88/NF-κB signaling pathway. Our findings might aid the development of novel therapies to treat progressive neurodegenerative diseases.PMID:33749522 | DOI:10.1080/01616412.2020.1866353 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: Wei Bi Xiaofeng Cheng Zhaohao Zeng Ruiyi Zhou Rixin Luo Jiawei Zhang Lihong Zhu Source Type: research

A Cortical Parcellation Based Analysis of Ventral Premotor Area Connectivity
Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.PMID:33749536 | DOI:10.1080/01616412.2021.1902702 (Source: Neurological Research)
Source: Neurological Research - March 22, 2021 Category: Neurology Authors: John R Sheets Robert G Briggs Nicholas B Dadario Isabella M Young Michael Y Bai Anujan Poologaindran Cordell M Baker Andrew K Conner Michael E Sughrue Source Type: research

Calpain activity in plasma of patients with essential tremor and Parkinson's disease: a pilot study
Conclusions: We observed general increase in the activity of calpains in plasma of both PD and ET patients that hints towards presence of the common steps in the pathogenesis of these diseases.PMID:33729106 | DOI:10.1080/01616412.2020.1854004 (Source: Neurological Research)
Source: Neurological Research - March 17, 2021 Category: Neurology Authors: Zamira M Muruzheva Dmitry S Traktirov Alexander S Zubov Nina S Pestereva Maria S Tikhomirova Marina N Karpenko Source Type: research

Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease
DISCUSSION: Our study in post-mortem human brains and transgenic AD mice provided neuropathological and functional evidence that cerebellar dysfunction may occur at the early stage of AD and likely independent of Aβ plaque.PMID:33688799 | DOI:10.1080/01616412.2021.1893566 (Source: Neurological Research)
Source: Neurological Research - March 10, 2021 Category: Neurology Authors: Kiran Chaudhari Linshu Wang Jonas Kruse Ali Winters Nathalie Sumien Ritu Shetty Jude Prah Ran Liu Jiong Shi Michael Forster Shao-Hua Yang Source Type: research