NF- κB 1-induced LINC00665 regulates inflammation and apoptosis of neurons caused by spinal cord injury by targeting miR-34a-5p.
Conclusion: inhibition of LINC00665 improved cell viability, suppressed apoptosis and inflammation in LPS-induced PC12 cells, and the NF-κB1/LINC00665/miR-34a-5ploop might be a useful therapeutic target in SCI treatment. PMID: 33435858 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 15, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Impact of β-range-induced oscillatory activity on human input-output relationship of the corticospinal pathway.
Discussion: β-rhythm tACS conditions only a definite subset of corticospinal elements influencing less than 30% of the entire motoneuronal pool. The fact that β-rhythm tACS mainly affects the most excitable motoneurons could explain the observed antikinetic effect of the tACS at β-rhythm applied in the motor regions. PMID: 33441044 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 15, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Application of the P300 potential in cognitive impairment assessments after transient ischemic attack or minor stroke.
Authors: Zhang Y, Xu H, Zhao Y, Zhang L, Zhang Y Abstract Background The aims of this study were to determine the relationships between changes inlatency and amplitude of the P300 event-related potential component and cognitive impairmentsin patients after a transient ischemic attack (TIA) or a minor stroke and to assess thesuitability of the P300 for screening for cognitive impairments. Material and Method Sixty-five TIA or minor stroke patients diagnosed at the NeurologyDepartment of Beijing Tiantan Hospital, Capital Medical University from June 2015 toDecember 2016 and 30 healthy people evaluated in the same per...
Source: Neurological Research - January 15, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Real world prognosis in MS: does early versus late diagnosis matter?
CONCLUSIONS: Patients in our MS clinic with EP versus LP were more likely to have multiple attacks in the first 2 years after onset and were treated earlier, but did not have a better 10- or 15-year outcome. PMID: 33432877 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 14, 2021 Category: Neurology Tags: Neurol Res Source Type: research

In spontaneous intracerebral hematoma patients, prediction of the hematoma expansion risk and mortality risk using radiological and clinical markers and a newly developed scale.
Conclusion: It was concluded that the GCS score, intraventricular haemorrhage, and BAT score could predict both hematoma expansion risk and mortality risk in the early stage in patients with ICH. Furthermore, it was suggested that the newly produced HEMRICH scale could be a valid and reliable scale for predicting both hematoma expansion and mortality risk. PMID: 33402048 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Impact of shoulder subluxation on peripheral nerve conduction and function of hemiplegic upper extremity in stroke patients: A retrospective, matched-pair study.
Authors: Li X, Yang Z, Wang S, Xu P, Wei T, Zhao X, Li X, Zhang Y, Li Y, Mei N, Wu Q Abstract Purpose: To investigate the impact of shoulder subluxation (SS) on peripheral nerve conduction and function of the hemiplegic upper extremity (HUE) in poststroke patients. Methods: Thirty post-stroke patients were selected (SS group: 15 patients, non-SS group: 15 patients, respectively). Evaluation of nerve conduction in upper limbs: the compound muscle action potential (CMAP) amplitude and latency of suprascapular, axillary, musculocutaneous, radial, median, and ulnar nerves; the motor and sensory conduction velocity and ...
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Down regulation of DNA topoisomerase II β exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase.
Down regulation of DNA topoisomerase IIβ exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson's disease by Down regulating tyrosine hydroxylase. Neurol Res. 2021 Jan 05;:1-10 Authors: Yeman KB, Isik S Abstract Initiating the transcriptional activation of neuronal genes, DNA topoisomerase IIβ (topo IIβ) has a crucial role in neural differentiation and brain development. Inhibition of topo IIβ activity causes shorter axons and deteriorated neuronal connections common in neurodegenerative diseases. We previously reported that topo IIβ silencing c...
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Association of inflammatory and platelet volume markers with clinical outcome in patients with anterior circulation ischaemic stroke after endovascular thrombectomy.
Conclusions: MPV, PDW, and MPV/PC are associated with stroke severity. Higher NLR levels upon admission may predict unfavorable functional outcomes in patients with AIS after undergoing EVT.Abbreviations ACA: anterior cerebral artery; AIS: acute ischemic stroke; ASPECTS: alberta stroke program early CT score; BMI: body mass index; DBP: diastolic blood pressure; END: early neurological deterioration; EVT: endovascular thrombectomy; hs-CRP: high-sensitivity C-reactive protein; HT: hemorrhagic transformation; ICA: internal carotid artery; IL-6: interleukin-6; IS: ischemic progression; LAA: Large-Artery Atherosclerosis; MCA: m...
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Advantages of magnetoencephalography, neuronavigation and intraoperative MRI in epilepsy surgery re-operations.
We report on 27 consecutive patients (13 female/14 male mean age at first surgery 29.4 years) who had operative revision of the first resection after failed epilepsy surgery. An improved seizure outcome postoperatively was observed in 78% of patients (p
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Premutations in the FMR1 gene in Serbian patients with undetermined tremor, ataxia and parkinsonism.
Conclusion: FXTAS was relatively rare among older patients with unexplained ataxia and action tremor, with or without parkinsonism and/or cognitive impairment. Tremor and ataxia were major clinical features in our two patients, although parkinsonism, autonomic dysfunction and psychiatric problems might be an important part of the spectrum. Probable FXTAS should be considered in the differential diagnosis of patients with unexplained action tremor and ataxia, and undetermined parkinsonism, especially when there was a positive family history for involuntary movement disorders in other family members and/or autism spectrum di...
Source: Neurological Research - January 8, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Involuntary, forced or voluntary exercise can ameliorate the cognitive deficits by enhancing levels of hippocampal NMDAR1, pAMPAR1 and pCaMKII in a model of vascular dementia.
Conclusion: Exercise induced by electrical stimulation has beneficial effects comparable to those of other types of exercise for alleviating the cognitive deficits of vascular dementia. PMID: 33393454 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - January 5, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Surround inhibition in patients with juvenile myoclonic epilepsy.
In this study, we aimed to investigate whether there was a decrease in SI of SEP in patients with juvenile myoclonic epilepsy (JME). METHODS: We included 17 patients with JME and 18 healthy subjects. Groups were similar in terms of age and gender. We recorded SEPs after stimulating (i) median nerve (mSEP), (ii) ulnar nerve (uSEP), (iii) median and ulnar nerves simultaneously (muSEP) at wrist. The arithmetic sum (aSEP) of amplitudes of mSEP and uSEP was compared with the amplitudes of muSEP. We also calculated SI%. RESULTS: The amplitudes of SEPs were significantly higher in the JME group than in the healthy subject...
Source: Neurological Research - January 2, 2021 Category: Neurology Tags: Neurol Res Source Type: research

Risk factors for in-hospital mortality among acute ischemic stroke patients in China: a nationwide prospective study.
Conclusions: The findings from this study may help clinicians control the risk of IHM better for patients with AIS. PMID: 33357098 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Posterior Fossa Decompression and superficial durotomy rather than complete durotomy and duraplasty in the management of Chiari 1.
Conclusion: We believe that a minimally invasive surgical method is superior to avoid major complications. We also found PFD and superficial durotomy shorten the duration of the patient's hospital stay Abbreviations: C1: cervical vertebra 1C2: cervical vertebra 2CM: Chiari malformationCM1: Chiari malformation type 1CSF: cerebrospinal fluidCT: computed tomographyMRI: magnetic resonance imagingPFD: posterior fossa decompressionUSG: ultrasonography. PMID: 33357109 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Delayed diagnosis of multiple sclerosis in a low prevalence country.
Conclusions: MS onset before the McDonald diagnostic criteria era is associated with delayed diagnosis. PMID: 33357115 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Prognostic significance of serum translocator protein in patients with spontaneous intracerebral hematoma :preliminary findings.
Prognostic significance of serum translocator protein in patients with spontaneous intracerebral hematoma:preliminary findings. Neurol Res. 2020 Dec 23;:1-6 Authors: Jiang W, Jin P, Bao Q, Wei W, Jiang W Abstract Background: The aim of this study was to measure the level of translocator protein (TSPO) in patients with intracerebral hematoma (ICH) and to determine whether TSPO can predict ICH outcomes. Method: Patients with ICH were recruited at Wujin Hospital Affiliated with Jiangsu University between January 2018 and May 2020. The level of TSPO and inflammatory factors were analyzed by enzyme-linked...
Source: Neurological Research - December 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Brain volume and perfusion asymmetry in temporal lobe epilepsy with and without hippocampal sclerosis.
Authors: Zhang Y, Dou W, Zuo Z, You H, Lv Y, Hou B, Shi L, Feng F Abstract Objectives : To detect and compare the features of interictal perfusion and volume asymmetry between temporal lobe epilepsy (TLE) patients with and without hippocampal sclerosis (HS). Methods : Sixty-one TLE patients (mean age 28.4 ± 9.3 years; 28 female/33 male) with unilateral signs of HS (TLE-HS+) and 25 TLE patients (mean age 29.8 ± 8.0 years; 17 female/8 male) without HS (TLE-HS-) were included. Thirty healthy volunteers served as controls (mean age 26.0 ± 8.7 years;...
Source: Neurological Research - December 16, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Tirofiban combined with heparin's effect and safety in the treatment of mild to moderate acute ischemic stroke.
Authors: Qiu T, Li C, Huang L, Xiao H, Deng X, Dai X, Fu S, Wang J, Gong Q, Luo Q, Wang M, He W, Chen M Abstract Tirofiban can be used to treat patients with acute ischemic stroke (AIS), this study was to evaluate the efficacy and safety of tirofiban combined with heparin in the treatment of mild to moderate AIS. A total of 98 patients with mild to moderate AIS randomly were divided into 2 groups within 48 h: the treatment group treated with tirofiban and, and the control group treated with aspirin + clopidogrel. The treatment group was given the same scheme as the control group after the treatment of tirofiba...
Source: Neurological Research - December 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection.
Conclusion: Emodin could inhibit the inflammatory response in the brain of mice with herpes virus encephalitis. The inhibition of TLR3 expression may play an important role in this process. PMID: 33274693 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - December 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Association of polymorphism -308G/A in tumor necrosis factor-alpha gene (TNF- α) and TNF-α serum levels in patients with relapsing-remitting multiple sclerosis.
Association of polymorphism -308G/A in tumor necrosis factor-alpha gene (TNF-α) and TNF-α serum levels in patients with relapsing-remitting multiple sclerosis. Neurol Res. 2020 Nov 30;:1-8 Authors: Grigorova AA, Trenova AG, Stanilova SA Abstract TNF-α is an important cytokine of the inflammatory response involved in the pathogenesis of relapsing-remitting multiple sclerosis (RRMS). The aim of this study is to explore the association between the promoter polymorphism -308G/A in the TNF-α gene (rs1800629) with genetic susceptibility to RRMS. Methods: A group of 183 RRMS patients a...
Source: Neurological Research - December 2, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Exome sequencing of a Pakistani family with spastic paraplegia identified an 18 bp deletion in the cytochrome B5 domain of FA2H.
Authors: Abbas S, Brugger B, Zubair M, Gul S, Blatterer J, Wenninger J, Rehman K, Tatrai B, Khan MA, Windpassinger C Abstract Hereditary spastic paraplegias (HSPs) are a diverse class of neurodegenerative disorders that mainly affect the corticospinal tract of the body and result in various clinical conditions such as lower limb spasticity and muscle weakness in the lower extremities. Worldwide, more than 70 chromosomal loci/genes have been reported to be associated with HSPs, out of which, six genes viz., ATL1, FA2H, GJC2, AP4E1, ALDH18A1 and ATP13A2 have been mapped in Pakistani families. In the present genetic s...
Source: Neurological Research - November 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

A novel idea for establishing Parkinson's disease mouse model by intranasal administration of paraquat.
Conclusion: This strategy provides a new idea and more convenient operation for the future study of mouse model of PD. PMID: 33213296 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 22, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Application of functional imaging, neuronavigation, and intraoperative MR imaging in the surgical treatment of brain cavernomas.
Conclusion: Neuronavigation together with intraoperative and functional MRI had a significant impact on resection amount, surgical time, and neurological and seizure outcome of supratentorial CM. In addition, iMRI was beneficial in few-selected cases. PMID: 33203321 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 21, 2020 Category: Neurology Tags: Neurol Res Source Type: research

LINC00943 knockdown attenuates MPP+-induced neuronal damage via miR-15b-5p/RAB3IP axis in SK-N-SH cells.
CONCLUSION: LINC00943 inhibition alleviated MPP+-induced neuronal injury via miR-15b-5p/RAB3IP axis, indicating a potential target for treatment of PD. PMID: 33208053 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 21, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Use of BRASS in sedated critically-ill patients as a predictable mortality factor: BRASS-ICU.
Authors: Legros V, Mourvillier B, Floch T, Candelier Q, Rosman J, Lafont B, Farkas JC, Bard M, Kanagaratnam L, Mateu P Abstract Objectives: To demonstrate that a BRASS score≥ 3 at admission of intubated, ventilated and sedated patients is predictive of mortality Methods: we have realized an Observational prospective multicenter study. All Major patients without neurological history, admitted to ICU for a non-neurological cause, sedated and admitted under mechanical ventilation were included. Results: One hundred and ten patients were included, the BRASS score as well as the FOUR and RASS scores were collected. A...
Source: Neurological Research - November 21, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Efficacy of arterial spin labeling magnetic resonance imaging with multiple post-labeling delays to predict postoperative cerebral hyperperfusion in carotid endarterectomy.
Conclusions: The slope index calculated by ASL with multiple PLDs is a useful screening tool to predict postoperative CHP after CEA. PMID: 33190623 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 18, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Can safe and radical resection of all types of parasagittal meningiomas be achievable? -the introduction of a simplified surgical strategy.
Conclusion: Radical and safe resection of all types of PSMs is achievable and not difficult if the simplified surgical strategy mentioned in the article is adopted, no matter to which extent the sinus is invaded. PMID: 33176620 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke.
CONCLUSION: The pretreatment of the transplanted umbilical cord stem cells in the striatum of ischemic rats possibly leads to restorative events, exerting a decreasing effect on cell death. Subsequently, these events may improve the motor ability and reduce ischemic injuries. PMID: 33167823 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 12, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Subarachnoid hemorrhage in C57BL/6J mice increases motor stereotypies and compulsive-like behaviors.
DISCUSSION: The findings suggest that parietal-entorhinal damage from SAH increases stereotyped motor behaviors and 'compulsive-like' behaviors without affecting cognition (learning and memory) or mood (anxiety and depression). This model can be used to better understand the neuropathophysiology following SAH that contributes to behavioral impairments in survivors with no gross sensory-motor deficits. PMID: 33135605 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - November 3, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Early permanent cerebrospinal fluid diversion in aneurysmal subarachnoid hemorrhage: does a lower rate of nosocomial meningitis outweigh the risk of delayed cerebral vasospasm related morbidity?
The objective of this study was to detect any association with symptomatic delayed cerebral vasospasm (DCVS), or delayed cerebral ischemia (DCI) by the time of hospital discharge. METHODS: We used a single-center dataset of aSAH patients who had received a permanent CSF diversion. We compared an 'early group' in which the procedure was performed up to 14 days after the ictus, to a 'late group' in which it was performed from the 15th day onward. RESULTS: Among 274 consecutive aSAH patients, 39 (14%) had a permanent CSF diversion procedure with a silver-coated EVD. While the blood clot burden was similarly distr...
Source: Neurological Research - October 29, 2020 Category: Neurology Tags: Neurol Res Source Type: research

BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice.
Authors: Wang J, Hu W, Feng Z, Feng M Abstract OBJECTIVE: To investigate the beneficial effect of brain-derived neurotrophic factor (BDNF) -overexpressing human umbilical cord mesenchymal stem cell (hUC-MSC)-derived motor neurons in the human Cu, Zn-superoxide dismutase1 (hSOD1)G93A amyotrophic lateral sclerosis (ALS) mice. METHODS: The BDNF gene was transfected into hUC-MSC-derived motor neurons by the lentivirus-mediated method. hSOD1G93A mice were assigned to the ALS, ALS/MN, and ALS/MN-BDNF groups, and intrathecally administrated phosphate-buffered saline (PBS), motor neurons, or motor neurons overexpressin...
Source: Neurological Research - October 22, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Dexmedetomidine improves postoperative neurocognitive disorder after cardiopulmonary bypass in rats.
CONCLUSIONS: Dexmedetomidine plays a neuroprotective role by inhibiting inflammation, apoptosis, and microglia activation in the prefrontal cortex and hippocampal DG region, and attenuates the cognitive deficit identified in the control group. PMID: 33076786 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 22, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Determination of cerebral blood flow velocity and microembolic signals in essential thrombocytosis by transcranial doppler ultrasonography.
This study aimed to evaluate the risk of cerebrovascular microembolism in ET patients due to detection of microembolic signals (MES) and measure cerebral blood flow velocity (CBFV) by Transcranial Doppler (TCD) ultrasonography. MATERIAL AND METHODS: In this prospective case-control study, forty patients with diagnosed ET and age and sex-matched forty healthy controls were examined by the TCD sonography. RESULTS: The ET group had a higher rate of MES (8/40) in the right MCA than that in the control group (none), as measured by TCD. Five patients had MES at the left MCA compared to that in no subjects in the control ...
Source: Neurological Research - October 20, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Prolonged distal latency of the median motor nerve is associated with poor prognosis in amyotrophic lateral sclerosis.
In conclusion, patients with ALS that have prolonged MMDL may have upper limb dysfunction and shorter survival. MMDL can be a useful prognostic marker for patients with ALS. Abbreviations: ADM = abductor digiti minimi; APB = abductor pollicis brevis; ALS = amyotrophic lateral sclerosis; ALSFRS-R = revised ALS Functional Rating Scale; CI = confidence interval; CMAP = compound muscle action potential; CTS = carpal tunnel syndrome; DL = distal latency; ΔFS = disease progression rate; FAB = frontal assessment battery; FVC = forced vital capacity; HR = hazard ratio; MCV = motor nerve conduction velocity; MMDL = median mot...
Source: Neurological Research - October 20, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Anterolateral approach for subaxial vertebral artery decompression in the treatment of rotational occlusion syndrome: results of a personal series and technical note.
DISCUSSION READ: Anterolateral approach allows for an effective and safe treatment of the ROS involving the subaxial portion of the VA. Retro-longus colli and pre-scalenic corridors, developed through a precarotid exposure, have an anatomical rationale in decreasing the risks of complications. Decompression stand-alone is adequate in almost the totality of cases. PMID: 33054694 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 20, 2020 Category: Neurology Tags: Neurol Res Source Type: research

P-Tau as prognostic marker in long term follow up for patients with shunted iNPH.
Conclusions: Low level of P-Tau is a useful CSF biochemical prognostic factor for good clinical outcome at least two years after shunt; meanwhile a lower Aβ1-42 might suggest that the pathophysiology of iNPH could have something in common with other neurodegenerative diseases of the elderly. PMID: 33059546 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 20, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF- κB pathway in glioma.
CONCLUSION: LIFR-AS1 could suppress the proliferation, migration and invasion and promote the apoptosis through modulating miR-4262/NF-κB pathway in glioma. PMID: 33070767 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - October 20, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Coping strategies used by patients with relapsing multiple sclerosis from Argentina: correlation with quality of life and clinical features.
Authors: Carnero Contentti E, López PA, Alonso R, Eizaguirre B, Pettinicchi JP, Tizio S, Tkachuk V, Caride A Abstract BACKGROUND: Multiple sclerosis (MS) is a chronic neurodegenerative and inflammatory disease. The adaptation to MS depends on the effectiveness of coping, which moderates the process of adaptation and psychological well-being. OBJECTIVES: We aimed to analyze the coping strategies of an Argentinean population of patients with MS (PwMS) and their association with clinical variables and health-related quality of life (QoL). METHODS: A nationwide cross-sectional study. Screening instrument...
Source: Neurological Research - October 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Two-dimensional structure analysis of hemifacial spasms and surgical outcomes of microvascular decompression.
Authors: Han S, Li Y, Li Z, Wang X, Gao J Abstract BACKGROUND: Although studies have indicated that the small posterior fossa plays a role in hemifacial spasm (HFS), few studies have denoted the correlations between local measurements of the cerebellopontine angle and the incidence of HFS and surgical outcomes. METHODS: We retrospectively analyzed the demographic and clinical data of HSF patients who underwent microvascular decompression at our institution. Healthy controls were recruited. The divergent prognosis of HFS was defined as an ordinal variable. A multivariable ordinal regression model was generated t...
Source: Neurological Research - October 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Assessments of regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration: a transected sciatic nerve model in rat.
Authors: Ebrahimi-Zadehlou P, Najafpour A, Mohammadi R Abstract PURPOSE: It is compulsory to make a tension-free, end-to-end repair in transected injuries. However, when it comes to longer defects, placement of an autograft or nerve conduits is required. The present study was designed to assess regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration in a transected sciatic nerve model in rat. METHODS: In NML group left sciatic nerve was exposed through a gluteal muscle incision and after careful hemostasis skin was closed. In TSC group left sciatic nerve w...
Source: Neurological Research - October 10, 2020 Category: Neurology Tags: Neurol Res Source Type: research

A Novel Variant in CWF19L1 Gene in a Family with Late-Onset Autosomal Recessive Cerebellar Ataxia 17.
CONCLUSION: In conclusion, we report a novel variant in CWF19L1 as a candidate causal variant in two sisters with autosomal recessive cerebellar ataxia. This is the first report coming from Arab countries. Additional reports in patients with a progressive course and adult-onset are needed, but this could be the first report of this disease diagnosed in adulthood since it is a disease of children and adolescents. In addition, our patients had epileptic seizures, which were not previously documented in patients with CWF19L1 mutations. We postulate that mutations in this gene have widespread functional and structural changes ...
Source: Neurological Research - October 7, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Functional outcome after critical illness in older patients: a population-based study.
We examined consecutive patients enrolled in the population-based Mayo Clinic Olmsted Study of Aging and then admitted to medical or surgical adult ICUs at Mayo Clinic, Rochester between January 1, 2006, and December 31, 2014 to determine one-year functional outcomes. RESULTS: 831cases were included. Mean age was 84 years (IQR 79-88). 569 (68.5%) patients were alive one year after ICU admission. Of them, 546 patients had functional assessment at one year and 367 (67.2%) had good functional outcome. On multivariable analysis, poor one-year functional outcome (death or disability) was more common among women, older ...
Source: Neurological Research - October 7, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Propofol ameliorates neuropathic pain and neuroinflammation through PPAR γ up-regulation to block Wnt/β-catenin pathway.
CONCLUSION: Propofol ameliorates NP and neuroinflammation of rats by up-regulating PPAR γ expression to block the Wnt/β-catenin pathway. PMID: 32985377 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 30, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Can the electrically stimulated manual muscle test differentiate upper from lower motor neuron injury in persons with acute SCI?
CONCLUSION: In our study, 70% of the muscles with a SMMT motor response of zero and 72% of the muscles with a SMMT motor response greater than or equal to one demonstrated SA on EMG. The use of the SMMT as a clinical measure to differentiate LMN from UMN integrity may be limited when applied. PMID: 32972329 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 27, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Screening for cognitive impairment with the montreal cognitive assessment at six months after stroke and transient ischemic attack.
CONCLUSION: The MoCA-Beijing cutoff score for differentiating CI from NCI after stroke and TIA at six months was at 24/25, and it is important for routine clinical practice. PMID: 32967577 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 26, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Systematic review of trauma system regionalization and implementation on outcomes in traumatic brain injury patients.
CONCLUSION: The existing literature on the effects of trauma system implementation or regionalization on outcomes in TBI is sparse but overall seems to convey an improvement in mortality. PMID: 32967585 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 26, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury.
Authors: Afshari K, Dehdashtian A, Haddad NS, Jazaeri SZ, Ursu DC, Khalilzadeh M, Haj-Mirzaian A, Shakiba S, Burns TC, Tavangar SM, Ghasemi M, Dehpour AR Abstract OBJECTIVES: To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this effect. METHODS: Using an aneurysm mini-clip model of contusive SCI, T9-10 laminectomies were performed for 60 male rats. Animals were divided into six experimental groups (n = 10 per group) as follows: a minocycline administered positive control group, a saline-vehicl...
Source: Neurological Research - September 17, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Leisure time physical activity in persons with spinal cord injury across the seasons.
CONCLUSION: LTPA in persons with SCI differs significantly in relation to the seasons throughout a year. The season of the year should be considered in future studies and interventions on LTPA in adults with SCI. PMID: 32912101 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - September 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Peripapillary microperimetry for the diagnosis and follow-up of papilledema in cases treated for idiopathic intracranial hypertension.
This study was a prospective non-comparative observational case series of patients with IIH. All patients underwent full ophthalmological examination, radiological imaging, and lumbar puncture, as well as microperimetric measurements around the optic nerve head. Patients were classified into a medical group, treated by weight reduction and acetazolamide, and a surgical group, treated by optic nerve sheath fenestration. Peripapillary microperimetric examinations were done at presentation and after one-month of treatment. Findings were compared to values obtained from an age-matched healthy control group. RESULTS: The st...
Source: Neurological Research - September 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The impact of botulinum toxin type A in the treatment of drooling in children with cerebral palsy secondary to Congenital Zika Syndrome: an observational study.
Authors: Sales HF, Cerqueira C, Vaz D, Medeiros-Rios D, Armani-Franceschi G, Lucena PH, Sternberg C, Nóbrega AC, Luz C, Fonseca D, Carvalho AL, Monteiro L, Siqueira IC, Bandeira ID, Lucena R Abstract OBJECTIVE: The main aim of this study was to determine the impact of botulinum toxin A (BTX-A) on severity and frequency of drooling in children with Cerebral Palsy (CP) secondary to Congenital Zika Syndrome (CZS). METHODS: This is a prospective longitudinal observational study including 23 children who received bilateral injections of BTX in the parotid and submandibular glands. The Thomas-Stonell & Gre...
Source: Neurological Research - September 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research