Is air pollution a potential cause of neuronal injury?
CONCLUSION: Gluconeogenesis was induced in human neural cells exposed to fine particles (DEP), in association with cell damage and oxidative stress. These findings suggest that the pathogenesis of cerebrovascular injury due to fine particle pollutant exposure may proceed through derangements in gluconeogenic metabolism. ABBREVIATIONS: DEP: diesel exhaust particles, ICA: intracranial atherosclerosis, ROS: reactive oxygen species. PMID: 31099309 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 19, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Insights into sleep-related hyper-motor epilepsy: an Egyptian case series.
CONCLUSIONS: Our data show relatively poor prognosis of SHE on medical therapy. Its outcome is significantly related to disease duration at the time of diagnosis. Abbreviation: SHE = Sleep related hypermotor epilepsy. PMID: 31084342 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Upregulated protein O-GlcNAcylation promoted functional and structural recovery of the contused spinal cord injury in rats by Thiamet-G treatment.
Discussion-We conclude that Thiamet-G induced elevated protein O-GlcNAcylation to ameliorate acute SCI, which could provide a potential novel therapeutic approach for SCI treatment. PMID: 31092134 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Application of functional near-infrared spectroscopy to explore the neural mechanism of transcranial direct current stimulation for post-stroke depression.
Authors: Li H, Zhu N, Klomparens EA, Xu S, Wang M, Wang Q, Wang J, Song L Abstract OBJECTIVES: We investigated the neural mechanism of transcranial direct current stimulation (tDCS) in the treatment of post-stroke depression (PSD) using functional near-infrared spectroscopy (fNIRS). METHODS: Twenty-six patients with PSD were randomly divided into an experimental group receiving tDCS and a control group receiving sham stimulation. The anode and cathode were placed on the left and right dorsolateral prefrontal cortex (PFC). Patients underwent fNIRS before and after treatment, combined with an emotional face sex j...
Source: Neurological Research - May 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Neuroinflammation caused by mental stress: the effect of chronic restraint stress and acute repeated social defeat stress in mice.
CONCLUSIONS: RSDS and CRS are two effective models of depressive behavior, and both models cause neuroinflammation, which may be responsible for the increased risk of CVD seen in patients with depression. PMID: 31092145 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Genetic analysis of ring finger protein 213 (RNF213) c.14576G > A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease.
CONCLUSIONS: In contrast to MMD patients, the prevalence of RNF213 c.14576G>A polymorphism was significantly lower in patients with intracranial VAD. The RNF213 gene polymorphism may preferentially affect the cerebrovascular lesion in the anterior circulation, which is originated from the primitive internal carotid arteries. The genetic background underlying intracranial VAD should be elucidated in future studies. ABBREVIATIONS: VAD: vertebral artery dissection; MMD: moyamoya disease; RNF213: ring finger protein 213; CAD: carotid artery dissection. PMID: 31064275 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 10, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Activation and blockade of dorsal hippocampal Serotonin6 receptors regulate anxiety-like behaviors in a unilateral 6-hydroxydopamine rat model of Parkinson's disease.
This study aimed to investigate the effect of serotonin6 (5-HT6) receptors in the dorsal hippocampus (dHip) on the regulation of Parkinson's disease (PD)-associated anxiety. METHODS: We examined whether intra-dHip injection of both 5-HT6 receptor agonist and antagonist was involved in the regulation of anxiety-like behaviors in sham-operated rats and rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle by the open-field and elevated plus maze (EPM) tests. Four weeks after injection of 6-OHDA, the concentrations of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) in rela...
Source: Neurological Research - May 7, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Saccular or dissecting aneurysms involving the basilar trunk: Endovascular treatment and clinical outcome.
CONCLUSION: In the treatment of BTAs, reconstructive EVT may provide a feasible and safe option to microsurgery. PMID: 31044652 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 4, 2019 Category: Neurology Tags: Neurol Res Source Type: research

In vitro and in vivo experiments of a novel intra-arterial neurovascular decompressor for treating neurovascular compression syndromes: a brief report.
DISCUSSION: An IA-NVD was created and tested to demonstrate its functionality and biocompatibility in the present experiments. The device may be safely applied to intracranial arteries, providing us a chance to test the efficacy of an upgrade version of the device on changing the course of an artery that compresses a cranial nerve. ABBREVIATIONS: CN = cranial nerve; EVT = endovascular treatment; H&E = hematoxylin and eosin; HFS = hemifacial spasm; IA-NVD = intra-arterial neurovascular decompressor; MVD = microvascular decompression; NVCS = neurovascular compression syndrome; REZ = root entry zone; SEM = scanning el...
Source: Neurological Research - May 4, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Balloon-mounted versus self-expanding stents for symptomatic intracranial vertebrobasilar artery stenosis combined with poor collaterals.
CONCLUSIONS: Stenting for patients with severe symptomatic intracranial vertebrobasilar arterial stenosis with poor collaterals can be performed safely with efficacy. Patients treated with balloon-mounted stents appear to have shorter operative times and lower re-stenosis rates than treated with self-expanding stents. PMID: 31030623 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Parkinson's disease with orthostatic hypotension: analyses of clinical characteristics and influencing factors.
This study was designed to investigate clinical symptoms and blood pressure (BP) characteristics in Parkinson's disease (PD) with orthostatic hypotension (OH), and to figure out the influencing factors of PD with OH (PD-OH). METHODS: Total 150 PD patients were divided into PD-OH and PD with no OH (PD-NOH) groups based on BP value. Series of scales were used to evaluate clinical symptoms. Twenty-four-hour ambulatory BP monitoring was adopted. RESULTS: Total 49 PD patients (32.67%) were with OH. PD-OH group had significantly older age, longer disease duration, more diabetes cases, higher levels of fasting blood gluco...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Brain ultrasound for diagnosis and prognosis in the neurological intensive care unit: a mini review for current development.
CONCLUSION: This review examines the current use of TCD monitoring in the NICU. Through review and continued development of similar non invasive technologies NICU care continues to innovate and evolve. Abbreviation: TCD: Transcranial Doppler. PMID: 31030634 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Clinical potential of pre-reperfusion hypothermia in ischemic injury.
Authors: Han Y, Rajah GB, Hussain M, Geng X Abstract The damage caused by ischemic stroke is mostly refractory to medical therapies and amounts to a substantial degree of mortality and morbidity in the world. The core tenet of treatment for acute ischemic stroke (AIS) is to save 'reversible' ischemic tissue (ischemic penumbra) as quickly as possible within a limited therapeutic time window. The neuroprotective effect of hypothermia has been proven previously in a large number of animal experiments and clinical trials. Some of these animal and human studies have shown that pre-reperfusion hypothermia can reduce myoc...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

A new physical-cognitive scale for assessment of frailty in Chinese Han elderly.
CONCLUSIONS: Our study revealed a significantly worse status in frail participants with CI than without. Our new scale shows a stronger correlation between frailty and complications than the classic phenotype. PMID: 31030646 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Predictive analytics and machine learning in stroke and neurovascular medicine.
Authors: Saber H, Somai M, Rajah GB, Scalzo F, Liebeskind DS Abstract Advances in predictive analytics and machine learning supported by an ever-increasing wealth of data and processing power are transforming almost every industry. Accuracy and precision of predictive analytics have significantly increased over the past few years and are evolving at an exponential pace. There have been significant breakthroughs in using Predictive Analytics in healthcare where it is held as the foundation of precision medicine. Yet, although the research in the field is expanding with the profuse volume of papers applying machine l...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

C-Fos mapping and EEG characteristics of multiple mice brain regions in pentylenetetrazol-induced seizure mice model.
CONCLUSIONS: These findings validated PTZ-induced seizure as a seizure model with a specific spatial-temporal profile. Neuronal activity was enhanced and then subsequently inhibited during seizure evolution. ABBREVIATIONS: AEDs: anti-epileptic drugs; AF: Alexa Fluor; CA1: Cornu Ammonis area 1; CA3: Cornu Ammonis area 3; DAB, 3: 3P-diaminobenzidine; DAPI: 4',6-diamidino-2-phenylindole; DG: dentate gyrus; EEG: electroencephalogram; GABA: gamma-aminobutyric acid; IEG: immediate early gene; mPFC: medial prefrontal cortex; NAc: nucleus accumbens; PB: phosphate buffer; PBS: phosphate buffered saline; PBST: phosphate buffered...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Rosuvastatin improves neurite extension in cortical neurons through the Notch 1/BDNF pathway.
DISCUSSION: These findings indicate that RSV mediates neurite outgrowth in primary cortical neurons. The RSV-induced neuritogenic effect is mediated at least partly via the Notch1/BDNF pathway. PMID: 31023175 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 27, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Cognitive and physical disability in Egyptian patients with multiple sclerosis: genetic and optical coherence tomography study.
DISCUSSION: Deficit in information processing speed measured by SDMT is a predictor of early progressive disability in MS patients. Thinning of RNFL and GCC is a potential biomarker for cognitive and physical disability in MS. The CC genotype of glutamate NMDAR gene has a divergent effect on visual and cognitive functions. PMID: 31025605 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 27, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Benzyl alcohol suppresses seizures in two different animal models.
CONCLUSION: BnOH is not an inert solvent. It has clear-cut anti-seizure effects against both focal and generalized seizures. PMID: 31025607 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 27, 2019 Category: Neurology Tags: Neurol Res Source Type: research

The long-non-coding RNA NEAT1 is a novel target for Alzheimer's disease progression via miR-124/BACE1 axis.
DISCUSSION: The present study showed that NEAT1 worked as a regulating factor to promote the development of AD via modulating miR-124/BACE1 axis, which might be considered as a novel target in AD treatment. PMID: 31014193 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 26, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Age and sex-mediated differences in six-month outcomes after mild traumatic brain injury in young adults: a TRACK-TBI study.
CONCLUSIONS: Following mTBI, young adults aged 18-29y and 30-39y may have different risks for impairment. Sex may interact with age for PTSD symptomatology, with females 30-39y at highest risk. These results may be attributable to cortical maturation, biological response, social modifiers, and/or differential self-report. Confirmation in larger samples is needed; however, prevention and rehabilitation/counseling strategies after mTBI should likely be tailored for age and sex. PMID: 31007155 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 24, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Dynamic expression of glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 in the mouse spinal cord dorsal horn under pathological pain states.
DISCUSSION: Under distinct pain conditions, GFAP and Iba-1 expression is dependent on the origin of the stimulus, disease progression and tissue affected. Moreover, their expression and is not necessarily associated to the behavior manifestation of pain. PMID: 31002029 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 20, 2019 Category: Neurology Tags: Neurol Res Source Type: research

From big data to battling disease: notes from the frontiers of cerebrovascular science.
Authors: Stone CR, Geng X, Ding Y PMID: 30983560 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.
This study aimed to investigate if rutin hydrate (RH), a well-reported neuroprotective and an antioxidant flavonoid, can ameliorate cadmium chloride (CdCl2)-induced neurotoxicity by inhibiting the resultant ER stress. Rats were divided into 4 groups (n = 16/group) of control, control + RH (100 mg/kg), CdCl2 (5 mg/kg), and CdCl2 + RH. All treatments were administered orally for 30 days, on daily basis. Brain homogenates from CdCl2-treated rats showed increased oxidative stress and induced activation of ER stress characterized by increasing mRNA and protein levels of GRP78, ATF-6, CHOP and Xbp-1 and prote...
Source: Neurological Research - April 13, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Low-dose ethanol ameliorates amnesia induced by a brief seizure model: the role of NMDA signaling.
Authors: Alinaghipour A, Mazoochi T, Ardjmand A Abstract OBJECTIVE: The present study aimed to evaluate the ameliorative effect of low-dose ethanol (Eth) on amnesia induced by a brief seizure model and the role of N-methyl D-aspartate (NMDA) signaling in this event. MATERIALS AND METHODS: Four groups of rats (total number = 36; n = 9, each group) were used: control, Eth (0.5 g/kg/i.p.), pentylenetetrazole (PTZ) (60 mg/kg/i.p.), and Eth+PTZ. Eth was administered for 6 days before the single injection of PTZ, at minute dose that cannot induce memory impairment. The consequences of Eth pretreatment, coadministered...
Source: Neurological Research - April 11, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Activation and blockade of serotonin4 receptors in the lateral habenula improve working memory in unilateral 6-hydroxydopamine-lesioned Parkinson's rats.
CONCLUSION: These findings suggested that unilateral lesions of the SNc induced working memory impairment and up-regulation of 5-HT4 receptors in the LHb. Activation and blockade of LHb 5-HT4 receptors improved working memory, that were related to the change of monoamines levels. Abbreviation: 6-OHDA: 6-hydroxydopamine; serotonin:5-HT; LHb: lateral habenula; PD: Parkinson's disease; SNc: substantia nigra pars compacta; DA: dopamine; NA: noradrenaline. PMID: 30929589 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 3, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Microalbuminuria in patients with acute ischemic stroke.
CONCLUSIONS: MAU was found in approximately one-third of patients with acute ischemic stroke. It was correlated with the severity of cerebral infarction at admission and clinical outcomes at 3 months after onset and could be used as a potential indicator of poor prognosis in ischemic stroke patients. PMID: 30931822 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - April 3, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Effect of inhibiting mitochondrial fission on energy metabolism in rat hippocampal neurons during ischemia/reperfusion injury.
CONCLUSION: Inhibition of mitochondrial fission significantly improved mitochondrial function and suppressed apoptotic signaling induced by I/R. PMID: 30919739 [PubMed] (Source: Neurological Research)
Source: Neurological Research - March 31, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Preparation and characterization of a novel acellular swim bladder as dura mater substitute.
DISCUSSION: The ASBs prepared via 'freezing-thawing and DNase-I' method had the ideal physical and biological properties as a dura mater substitute for clinical application. PMID: 30912483 [PubMed - in process] (Source: Neurological Research)
Source: Neurological Research - March 28, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis.
Conclusion The LZC can be used as one of the diagnostic indexes meanwhile the trend and degree of its change can be used as the reference index of curative effect to neurosyphilis. PMID: 30912484 [PubMed - in process] (Source: Neurological Research)
Source: Neurological Research - March 28, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Characteristics of patients with vitamin B12-responsive neuropathy: a case series with systematic repeated electrophysiological assessment.
CONCLUSION: B12-responsive neuropathy is a more heterogeneous group of neuropathy than previously described. B12 deficiency is a cause of peripheral neuropathy and should systematically be ruled out in the clinical setting of idiopathic neuropathy or sensory neuronopathy because of potential reversibility. ABBREVIATIONS: B12: vitamin B12; CMAP: compound muscle action potentials; DRG: dorsal root ganglia; ENMG: electroneuromyography; MCCT: motor central conduction time; MEP: motor evoked potentials; MMA: methylmalonic acid; MMCoAM: L-methylmalonyl-CoenzymeA mutase; ONLS: overall neuropathy limitations scale; SCV: sensor...
Source: Neurological Research - March 21, 2019 Category: Neurology Tags: Neurol Res Source Type: research

The effect of harmaline on seizures induced by amygdala kindling in rats.
Authors: Alenajaf A, Mohebi E, Moghimi A, Fereidooni M, Mohammad-Zadeh M Abstract OBJECTIVE: Harmaline and other beta-carbolines act as an inverse agonist for GABA-A receptors and cause central nervous system stimulation and anxiety; thus, it may act hypothetically as a potential seizure augmenter. To examine the hypothesis, the effect of harmaline during the seizures induced by amygdala kindling is investigated here. METHODS: Seven groups of male rats were kindled by daily electrical stimulation of the amygdala. After being kindled, Groups I-III, respectively, received 5, 15 and 50 mg/kg harmaline through...
Source: Neurological Research - March 21, 2019 Category: Neurology Tags: Neurol Res Source Type: research

The effect of lithium chloride on BDNF, NT3, and their receptor mRNA levels in the spinal contusion rat models.
CONCLUSION: Our findings suggest that LiCl protects neural cells and effectively enhances locomotor function, which was done through up-regulation of endogenous BDNF expression in rats with SCI. ABBREVIATIONS: SCI: spinal cord injury; LiCl: lithium chloride; BDNF: Brain-derived neurotrophic factor; NT3: Neurotrophin-3; BBB: Basso, Beattie, Bresnahan; TrkB: Tropomyosin receptor kinase B; TUNEL: Terminal deoxynucleotidyl transferase dUTP nick end labeling. PMID: 30879425 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 20, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Microarray gene expression profiling and bioinformatics analysis reveal key differentially expressed genes in clival and sacral chordoma cell lines.
CONCLUSION: This study helps to further understand the molecular characteristics of classic chordomas of two distinct sites. Hub genes FYN, ITGB3, ACTN2, and IGF1, as well as focal adhesion signaling pathway, would be new targets for future treatment options of chordomas. PMID: 30821656 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Forward deployed coil embolization with multiple overlapping stents for ruptured blood blister-like aneurysms: technical considerations and outcomes.
CONCLUSIONS: Forward deployed coil embolization with multiple overlapping stents offers a safe and effective reconstructive endovascular technique for the treatment of the BBAs. PMID: 30821662 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment.
CONCLUSIONS: The multimodal action of this molecule could mediate the memory protection here observed and suggest that it may modulate different pathological aspects of memory deficits associated with AD in humans. PMID: 30821663 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
DISCUSSION: Our findings suggested that three times or more per week of high-intensity preconditioning exercise exert neuroprotective effects through the downregulation of the Bax/Bcl-2 ratio and caspase-3 activation after stroke. ABBREVIATIONS: TUNEL: terminal deoxynucleotidyl transferase-mediated biotinylated dUTP nick and labeling; MCAO:middle cerebral artery occlusion; BAX:Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; TTC: 2,3,5-triphenyltetrazorlium chloride. PMID: 30822224 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
DISCUSSION: These data show, for the first time, that MRT has beneficial effects against diabetes-induced hyperalgesia, and that suppressive effect of this drug on TRPV1 and ASIC1 levels, which are increased in diabetic rats, may be some of the pharmacological mechanisms underlying the exhibited antihyperalgesic effect of MRT. PMID: 30822229 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Low-dose rt-PA may not decrease the incidence of symptomatic intracranial haemorrhage in patients with high risk of symptomatic intracranial haemorrhage.
CONCLUSIONS: Our study suggests that low-dose intravenous rt-PA for high-risk sICH stroke in Chinese patients may not decrease the incidence of sICH, and concomitant with a poor outcome compared to standard-dose rt-PA. ABBREVIATIONS: rt-PA: recombinant tissue plasminogen activator; AIS: acute ischemic stroke; sICH: symptomatic intracranial haemorrhage. PMID: 30822264 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Family history of stroke and death or vascular events within one year after ischemic stroke.
Authors: Zheng X, Zeng N, Wang A, Zhu Z, Peng H, Zhong C, Xu T, Xu T, Peng Y, Li Q, Ju Z, Geng D, Zhang Y, He J Abstract BACKGROUND AND AIMS: The association between family history of stroke and clinical outcomes after ischemic stroke remains unclear. METHODS: A total of 3878 acute ischemic stroke patients from CATIS were included. The participants with ischemic stroke were divided into groups according to types of family history of stroke, stroke onset age and stroke subtypes. The primary outcome was a composite outcome of death and vascular events within 1 year after stroke. Multivariable Cox proportional haz...
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Exposure to female estrous is beneficial for male mice against transient ischemic stroke.
CONCLUSION: Exposure to female estrous reduces mortality and improves functional recovery in MCAO male mice. The study provides the first evidence to support the importance of female interaction to male stroke rehabilitation. ABBREVIATIONS: GAP-43: growth-associated protein-43; SYP: Synaptophysin; MCAO: middle cerebral artery occlusion; OVXs: ovariectomies; CCA: common carotid artery; ECA: external carotid artery; EFE: estrous female exposure; TTC: 2,3,5-triphenyltetrazolium chloride; PAGE: polyacrylamide gel electrophoresis; PVDF: polyvinylidene difluoride; ANOVA: analysis of variance; LSD: least significant differenc...
Source: Neurological Research - March 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Cilostazol may improve cognition better than clopidogrel in non-surgical adult patients with ischemic moyamoya disease: subanalysis of a prospective cohort.
Authors: Ando S, Tsutsui S, Miyoshi K, Sato S, Yanagihara W, Setta K, Chiba T, Fujiwara S, Kobayashi M, Yoshida K, Kubo Y, Ogasawara K Abstract OBJECTIVE: Adult patients with ischemic moyamoya disease (MMD) who receive treatment with antiplatelet drugs reportedly show improvements in neuropsychological test scores after around 2 years. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, results in better improvement of cognitive function among non-surgical adult patients showing ischemic MMD without ...
Source: Neurological Research - February 19, 2019 Category: Neurology Tags: Neurol Res Source Type: research

COX-2 contributed to the remifentanil-induced hyperalgesia related to ephrinB/EphB signaling.
Conclusions: Our findings confirmed that COX-2 is involved in remifentanil-induced hyperalgesia related to ephrinB/EphB signaling. EphrinB/EphB signaling might be the upstream of COX-2. PMID: 30759061 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

ECAS progression score: a web-based model to predict progression of extracranial carotid artery stenosis.
CONCLUSION: The ECAS progression score is a valid model for predicting the risk of ECAS progression. Further validation of the ECAS-PS in different populations and larger samples is warranted. PMID: 30759062 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model.
CONCLUSIONS: Observed results suggested that paeoniflorin could ameliorate the symptoms and improve the functional capability of PSD rats, similar to the effect of fluoxetine. ABBREVIATIONS: PSD: post-stroke depression; CUMS: chronic unpredictable mild stress stimulation; MCAO: middle cerebral artery occlusion; OFT: open field test; SPT: sucrose preference test, NDS: neurological deficit score, BBT: beam balance test; BDNF: brain-derived neurotrophic factor protein; p-CREB: phosphorylated Cyclic-AMP responsive element binding protein. PMID: 30759063 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.
The objective of this study was to investigate the expression of serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) and their correlation with clinicopathological features. METHODS: Fifty AD subjects and 50 healthy controls were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of TRF1 and TRF2 in the peripheral blood plasma. Correlation analysis was used to evaluate the correlation between the protein expression and AD clinical parameters. RESULTS: The expression of TRF1 in peripheral blood serum of AD patients was s...
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Progesterone treatment in rats after severe global cerebral ischemia promotes hippocampal dentate gyrus neurogenesis and functional recovery.
CONCLUSION: These findings show that post-ischemia P4 treatment, following an episode of severe global cerebral ischemia, promotes the survival of newly generated hippocampal neurons in the DG, which may be one of the mechanisms of cerebral plasticity induced by the hormone, that underlie a successful functional performance in learning and memory tests. PMID: 30762490 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.
Authors: Fu CY, Chen SJ, Cai NH, Liu ZH, Zhang M, Wang PC, Zhao JN Abstract OBJECTIVES: We attempted to determine whether a functional polymorphism of TRPM6 (rs2274924) is associated with susceptibility to epilepsy following ischemic stroke, and to further explore the effect of this polymorphism on serum levels of Mg2+ in post-stroke patients. METHODS: We carried out a case-control study on 378 post-stroke epilepsy patients and 420 controls (stroke patients without secondary epilepsy). We used DNA sequencing to determine the genotypes of the TRPM6 rs2274924 polymorphism, and used the ion selective electrode met...
Source: Neurological Research - February 12, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression.
CONCLUSIONS:  These results suggest that hypofunctional BDNF-TrkB signaling may contribute to depression in epilepsy. ABBREVIATIONS: BDNF: Brain-derived neurotrophic factor; TrkB: tyrosine kinase B; UCMS: unpredicted chronic mild stress; PBS: phosphate-buffered saline; HS: Hippocampal sclerosis. PMID: 30741614 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - February 12, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Effect of folic acid supplementation on nerve conduction velocity in diabetic polyneuropathy patients.
The objective of this study was to determine the effect of folic acid supplementation on NCV in DPN patients. METHODS: Patients were randomized to receive either 1 mg of folic acid (n = 40) or placebo (n = 40) for 16 weeks. Blood samples were collected to assess serum folic acid and homocysteine concentrations, and NCV was performed for assessment of diabetic neuropathy. RESULTS: At 16 weeks, in the supplemented group, serum levels of folic acid (p 
Source: Neurological Research - February 9, 2019 Category: Neurology Tags: Neurol Res Source Type: research