New bidirectional arterial perfusion device.
PMID: 32031047 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - February 7, 2020 Category: Transplant Surgery Authors: Abdel-Sayed S, Ferrari E, Abdel-Sayed P, Wilhelm M, Halbe M, von Segesser LK, Maisano F, Berdajs D Tags: Int J Artif Organs Source Type: research

Validation of numerically simulated ventricular flow patterns during left ventricular assist device support.
Abstract Intraventricular flow patterns during left ventricular assist device support have been investigated via computational fluid dynamics by several groups. Based on such simulations, specific parameters for thrombus formation risk analysis have been developed. However, computational fluid dynamic simulations of complex flow configurations require proper validation by experiments. To meet this need, a ventricular model with a well-defined inflow section was analyzed by particle image velocimetry and replicated by transient computational fluid dynamic simulations. To cover the laminar, transitional, and turbule...
Source: The International Journal of Artificial Organs - February 5, 2020 Category: Transplant Surgery Authors: Ghodrati M, Khienwad T, Maurer A, Moscato F, Zonta F, Schima H, Aigner P Tags: Int J Artif Organs Source Type: research

Development of a circulatory mock loop for biventricular device testing with various heart conditions.
This study aimed to evaluate a newly designed circulatory mock loop intended to model cardiac and circulatory hemodynamics for mechanical circulatory support device testing. The mock loop was built with dedicated ports suitable for attaching assist devices in various configurations. This biventricular mock loop uses two pneumatic pumps (Abiomed AB5000™, Danvers, MA, USA) driven by a dual-output driver (Thoratec Model 2600, Pleasanton, CA, USA). The drive pressures can be individually modified to simulate a healthy heart and left and/or right heart failure conditions, and variable compliance and fluid volume allow for...
Source: The International Journal of Artificial Organs - February 4, 2020 Category: Transplant Surgery Authors: Kado Y, Miyamoto T, Horvath DJ, Gao S, Fukamachi K, Karimov JH Tags: Int J Artif Organs Source Type: research

Identification and characterisation of fluorescent substances in spent dialysis fluid.
r C Abstract Patients who suffer from end-stage renal disease require renal replacement therapy, including haemodialysis. While applying extracorporeal blood treatment, uraemic toxins accumulated in the patients' blood pass into a physiological solution, the dialysis fluid. Thus, important information about the patient's health status can be obtained by analysing the spent dialysis fluid. To make use of this information, corresponding analysis concepts must be developed. In this context, this article reports the analysis of fluorescence in spent dialysis fluid. Excitation and emission maxima of fluorescence in spe...
Source: The International Journal of Artificial Organs - February 4, 2020 Category: Transplant Surgery Authors: Meibaum J, Krause S, Hillmer H, Marcelli D, Strohhöfer C Tags: Int J Artif Organs Source Type: research

Evaluation of intradialytic sodium shifts during sodium controlled hemodialysis.
Abstract Plasma sodium shifts during hemodialysis treatments can be minimized by application of a sodium control algorithm. The present randomized cross-over trial was designed to apply this option on a large patient cohort and to observe the time course of plasma sodium over the treatment. In one study phase, patients received post-dilution online hemodiafiltration treatments with sodium control over the entire treatment. In the other study phase, patients received isolated ultrafiltration during the first 90 min followed by post-dilution online hemodiafiltration with sodium control for the remainder of th...
Source: The International Journal of Artificial Organs - February 4, 2020 Category: Transplant Surgery Authors: Ponce P, Pinto B, Wojke R, Maierhofer AP, Gauly A Tags: Int J Artif Organs Source Type: research

A novel serum: Electrophoresis method to prepare acellular corneal matrix as an artificial corneal scaffold.
CONCLUSIONS: The transparency and appearance of serum-electrophoresis acellular porcine corneal matrix were better than serum acellular porcine corneal matrix. DNA and α-gal in serum-electrophoresis acellular porcine corneal matrix were more efficiently removed than those in serum acellular porcine corneal matrix (p 
Source: The International Journal of Artificial Organs - February 1, 2020 Category: Transplant Surgery Authors: Li Q, Xie C, Wang H, Zhang F, Mu L Tags: Int J Artif Organs Source Type: research

Hemoperfusion with Cytosorb in pediatric patients with septic shock: A retrospective observational study.
CONCLUSION: The use of Cytosorb in combination with Continuous Renal Replacement Therapy as blood purification strategy in pediatric septic shock is associated with a rapid hemodynamic stabilization in the first 48 h of treatment and a significant reduction of interleukin-6 and interleukin-10. PMID: 32003289 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 31, 2020 Category: Transplant Surgery Authors: Bottari G, Guzzo I, Marano M, Stoppa F, Ravà L, Di Nardo M, Cecchetti C Tags: Int J Artif Organs Source Type: research

Pulmonary artery pressure may be a predictor of closed aortic valve in patients managed by venoarterial extracorporeal membrane oxygenation.
Abstract In the management of venoarterial extracorporeal membrane oxygenation, some patients present persistently closed aortic valve. However, little is known about the variables that contribute to persistently closed aortic valve. We investigated the factors that could predict persistently closed aortic valve at the time of venoarterial extracorporeal membrane oxygenation initiation. We investigated 17 patients who presented closed aortic valve immediately after the introduction of venoarterial extracorporeal membrane oxygenation. Patients who presented closed aortic valve 24 h after introduction of veno...
Source: The International Journal of Artificial Organs - January 31, 2020 Category: Transplant Surgery Authors: Yamaguchi S, Sawamura A, Okumura T, Kato H, Oishi H, Arao Y, Haga T, Kuwayama T, Yokoi T, Hiraiwa H, Kondo T, Morimoto R, Murohara T Tags: Int J Artif Organs Source Type: research

Inflow cannula obstruction in Berlin Heart Excor and novel extracorporeal membrane oxygenation cannulation for rescue.
We describe the diagnosis, intervention, as well as novel rescue using existing cannulae for extracorporeal membrane oxygenation support. PMID: 31996067 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 29, 2020 Category: Transplant Surgery Authors: Deshpande SR, Desai M, Sinha P, Kanter J, Yerebakan C Tags: Int J Artif Organs Source Type: research

Neuropathological findings in comatose patients with venoarterial extracorporeal membrane oxygenation.
Abstract We sought to describe the relation between neuropathology and clinical information including neurological examination and electroencephalogram findings in extracorporeal membrane oxygenation. We reviewed the patients who had undergone brain autopsy from November 2017 through December 2018. Four patients with neuromonitoring had post mortem examination with brain autopsy. The median age was 56, and all had venoarterial extracorporeal membrane oxygenation cannulation. There was no known acute neurologic injury prior to extracorporeal membrane oxygenation. While on extracorporeal membrane oxygenation, all we...
Source: The International Journal of Artificial Organs - January 29, 2020 Category: Transplant Surgery Authors: Cho SM, Geocadin RG, White B, Chen LL Tags: Int J Artif Organs Source Type: research

Left ventricle assist device pulsatility index at the time of implantation is associated with follow-up pulmonary hemodynamics.
Abstract HeartMate II left ventricular assist device controllers provide data including pulsatility index, reflecting the relationship between pump function and hemodynamics. We propose that a higher pulsatility index at hospital discharge following implant may be associated with less vascular congestion and improved clinical outcomes. A retrospective analysis of 40 patients (age 59.2 ± 10.3 years) supported with the HeartMate II devices was conducted. Data revealed moderate Pearson correlations between pulsatility index at discharge and right atrial pressure, pulmonary artery systolic ...
Source: The International Journal of Artificial Organs - January 27, 2020 Category: Transplant Surgery Authors: Schaefer JJ, Sajgalik P, Kushwaha SS, Olson LJ, Stulak JM, Johnson BD, Schirger JA Tags: Int J Artif Organs Source Type: research

Streptococcus pyogenes purpura fulminans and septic shock: A case highlighting the ethical considerations of high-risk extracorporeal membrane oxygenation.
We report a novel case of refractory shock requiring veno-arterial extracorporeal membrane oxygenation and continuous renal replacement therapy due to Streptococcus pyogenes bacteremia with purpura fulminans to highlight the ethical challenges in offering extracorporeal membrane oxygenation to a patient with such a poor likelihood of survival. PMID: 31984828 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 25, 2020 Category: Transplant Surgery Authors: Wheaton T, Menkiti O, Misra A Tags: Int J Artif Organs Source Type: research

Minimum inhibitory concentration changes in relapsed left ventricular assist device driveline infections.
Abstract Driveline infection is the most common infectious complication in patients with left ventricular assist devices. Minimum inhibitory concentration changes are not well described in relapsed driveline infections. This retrospective descriptive epidemiology study of patients with left ventricular assist device implantation between January 1, 2013, and August 1, 2017, who developed driveline infection with positive cultures aimed to describe minimum inhibitory concentration changes. Of the 330 patients underwent left ventricular assist device implantation, 30 (9%) met criteria for driveline infection. Median ...
Source: The International Journal of Artificial Organs - January 22, 2020 Category: Transplant Surgery Authors: Lines TH, Sabato LA, Nesbitt WJ, Moretz JD, Brinkley DM, Satyanarayana G Tags: Int J Artif Organs Source Type: research

Differences in predicting glucose absorption from peritoneal dialysate compared to measured absorption in peritoneal dialysis patients treated by continuous ambulatory peritoneal dialysis and ambulatory peritoneal dialysis cyclers.
CONCLUSION: Although formally measuring peritoneal glucose absorption is time consuming and requires patient co-operation, current predictive equations overestimate glucose absorption and do not provide accurate estimations of glucose absorption particularly for automated peritoneal dialysis patients. PMID: 31960740 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 21, 2020 Category: Transplant Surgery Authors: Tangwonglert T, Davenport A Tags: Int J Artif Organs Source Type: research

Acute effect of one session of hemodiafiltration with endogenous reinfusion on uremic toxins and inflammatory mediators.
CONCLUSION: The hemodiafiltration with endogenous infusion system is a new dialysis technique that combines diffusion, convection, and adsorption processes. It allows for extensive solute removal, including protein-bound uremic toxins and some pro-inflammatory cytokines, but does not cause nutrient loss and inflammatory response during the treatment. Although the effect after a single hemodiafiltration with endogenous infusion session is limited, it may be improved by repeated and long-term treatment. PMID: 31942823 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 16, 2020 Category: Transplant Surgery Authors: Chen X, Shen B, Cao X, Xiang F, Zou J, Ding X Tags: Int J Artif Organs Source Type: research

Inhibition of hyperplasia during the implantation of the puborectalis-like artificial anal sphincter.
CONCLUSION: All methods posted in this study were evaluated to be effective to prolong the implantation lifetime of the puborectalis-like artificial anal sphincter. Among the methods proposed, the most effective was the addition of the outer shell to the puborectalis-like artificial anal sphincter. The least effective method was the improvement of the transmission structure. Medical titanium alloy and polyetheretherketone were good replacements for nylon-12 that managed to extend the implantation lifetime and yield a moderate improvement. PMID: 31928125 [PubMed - as supplied by publisher] (Source: The International Jo...
Source: The International Journal of Artificial Organs - January 13, 2020 Category: Transplant Surgery Authors: Zhou Z, Yan G, Wang Z, Jiang P, Yao S, Ding Z, Hua F Tags: Int J Artif Organs Source Type: research

Development of a prototype anti-pollution filter for volatile anesthetics.
CONCLUSION: The new version of our prototype filter adsorbed most of the volatile anesthetics agents during an ex-vivo simulated conventional cardiopulmonary bypass test. PMID: 31894709 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 2, 2020 Category: Transplant Surgery Authors: Nigro Neto C, Andrade AJP, Leal E, Bezerra FJL, Lomivorotov V, Landoni G Tags: Int J Artif Organs Source Type: research

Effect of the valve design on pressure drop, pressure recovery, and spatial positioning of vena contracta.
CONCLUSION: The design of bioprosthesis affects pressure recovery and the position of the vena contracta. The different patterns of pressure recovery might have clinical impact. PMID: 31894714 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 2, 2020 Category: Transplant Surgery Authors: Tasca G, Lucherini F, Romagnoni C, Jaworek M, Redaelli A, Antona C, Vismara R Tags: Int J Artif Organs Source Type: research

Initial conservative management strategy of HeartWare left ventricular assist device thrombosis with intravenous heparin or bivalirudin.
ler S Abstract INTRODUCTION AND OBJECTIVES: Pump thrombosis is a serious left ventricular assist device complication, though there are no guidelines regarding its treatment. The main aim of this study was to describe a strategy of intravenous anticoagulation as the initial treatment in these patients and then to compare intravenous heparin with bivalirudin. METHODS: All consecutive patients who received a HeartWare left ventricular assist device from July 2009 to March 2019 were retrospectively analysed. Patients developing a pump thrombosis were selected, and treatment, outcomes and complications were record...
Source: The International Journal of Artificial Organs - December 30, 2019 Category: Transplant Surgery Authors: Bouzas-Cruz N, Gonzalez-Fernandez O, Ferrera-Durán C, Woods A, Robinson-Smith N, Tovey S, Jungschleger J, Booth K, Shah A, Parry G, MacGowan GA, Schueler S Tags: Int J Artif Organs Source Type: research

Biocompatibility of a polymer-coated membrane possessing a hydrophilic blood-contacting layer: Adsorption-related assessment.
CONCLUSION: This study suggests that albumin is not adsorbed on either acrylate-based copolymer-coated or non-coated membranes, that lysozyme is not adsorbed on either membrane or is adsorbed at a similar rate on both membranes, and that vancomycin is less adsorbed on acrylate-based copolymer-coated membranes. Thus, acrylate-based copolymer coating could inhibit the adsorption of various peptide compounds. PMID: 31875413 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 25, 2019 Category: Transplant Surgery Authors: Tagaya M, Okano S, Murataka T, Handa H, Ichikawa S, Takahashi S Tags: Int J Artif Organs Source Type: research

Hemoadsorption by extracorporeal cytokine adsorption therapy (CytoSorb ®) in the management of septic shock: A retrospective observational study.
This study was conducted to understand any beneficial effects of CytoSorb® therapy in septic patients. METHODOLOGY: This was a retrospective and observational study, approved by the scientific and ethics committee of Max Super Specialty Hospital, Patparganj, Delhi, India and conducted in compliance with current International Council for Harmonization, Good Clinical Practice, Schedule Y, and Indian Council of Medical Research guidelines. Subjects of either gender (age > 18 year) were included in the study. The data were presented as mean ± standard deviation and categori...
Source: The International Journal of Artificial Organs - December 23, 2019 Category: Transplant Surgery Authors: Singh YP, Chhabra SC, Lashkari K, Taneja A, Garg A, Chandra A, Chhabra M, Singh GP, Jain S Tags: Int J Artif Organs Source Type: research

Hemoadsorption treatment with CytoSorb ® in patients with extracorporeal life support therapy: A case series.
Hemoadsorption treatment with CytoSorb® in patients with extracorporeal life support therapy: A case series. Int J Artif Organs. 2019 Dec 23;:391398819895287 Authors: Träger K, Skrabal C, Fischer G, Schroeder J, Marenski L, Liebold A, Reinelt H, Datzmann T Abstract INTRODUCTION: Extracorporeal life support is an increasingly used technique for respiratory and cardiocirculatory support. Besides primary organ dysfunction, an excessive systemic hyperinflammatory response can be the underlying cause for acute organ failure necessitating extracorporeal life support therapy, or it may be associated...
Source: The International Journal of Artificial Organs - December 23, 2019 Category: Transplant Surgery Authors: Träger K, Skrabal C, Fischer G, Schroeder J, Marenski L, Liebold A, Reinelt H, Datzmann T Tags: Int J Artif Organs Source Type: research

Double purse-string around the inner cuff of the peritoneal catheter: A novel technique for an immediate initiation of continuous peritoneal dialysis.
Abstract International guidelines recommended a delayed start of peritoneal dialysis at least 2 weeks between catheter insertion and continuous peritoneal dialysis therapy initiation (break-in period). Up to now, the optimal duration of the break-in period is still unclear. The aim of our study was to evaluate in patients, with immediate initiation of continuous peritoneal dialysis, the efficacy of a double purse-string around the inner cuff in preventing mechanical and infectious complications either in semi-surgical or surgical catheter implantation. From January 2011 to December 2018, 135 peritoneal dial...
Source: The International Journal of Artificial Organs - December 19, 2019 Category: Transplant Surgery Authors: Scalamogna A, Nardelli L, Zanoni F, Messa P Tags: Int J Artif Organs Source Type: research

Development of a self-pumping extracorporeal blood oxygenation device characterized by a rotating shaft with embedded fiber packages.
CONCLUSION: Although the study did not include animal testing, the novel pump-oxygenator solution is feasible for respiratory support in patients with lung diseases. PMID: 31856633 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 19, 2019 Category: Transplant Surgery Authors: Rinaudo A, Pasta S Tags: Int J Artif Organs Source Type: research

Regional citrate versus systemic heparin anticoagulation for continuous renal replacement therapy in critically ill children.
CONCLUSION: Our study showed that citrate is superior in terms of safety and efficacy, with longer filter life span. Regional citrate should be considered as a better anticoagulation method than heparin for continuous renal replacement therapy in critically ill children. PMID: 31856634 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 19, 2019 Category: Transplant Surgery Authors: Sık G, Demirbuga A, Annayev A, Citak A Tags: Int J Artif Organs Source Type: research

Incomplete Cushing's reflex in extracorporeal membrane oxygenation.
We report a case of intracranial hypertension presenting with bradycardia as the only component of Cushing's triad in a patient on extracorporeal membrane oxygenation. A 41-year-old woman with recurrent driveline infections of HeartMate-II had sternotomy and debridement that was complicated by right ventricular failure requiring veno-arterial extracorporeal membrane oxygenation. Patient was comatose and acute onset of bradycardia occurred without any change in blood pressure or respiration. Computed tomography of brain demonstrated an uncal herniation from diffuse cerebral edema. Acute onset of bradycardia in comatose pati...
Source: The International Journal of Artificial Organs - December 19, 2019 Category: Transplant Surgery Authors: Cho SM, Kilic A, Dodd-O JM Tags: Int J Artif Organs Source Type: research

The possibility of using effluent ionized calcium to assess regional citrate anticoagulation in continuous renal replacement therapy.
CONCLUSION: The effluent ionized calcium could be a considerable substitute for post-filter ionized calcium to monitor the validity of regional citrate anticoagulation in continuous renal replacement therapy with less blood loss. PMID: 31849251 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 18, 2019 Category: Transplant Surgery Authors: Zhang Q, Zhuang F, Fan Q, Yu W, Ding F Tags: Int J Artif Organs Source Type: research

Infrastructural needs and expected benefits of telemonitoring in left ventricular assist device therapy: Results of a qualitative study using expert interviews and focus group discussions with patients.
CONCLUSION: Although positive expectations are associated with the use of telemonitoring in left ventricular assist device therapy, further action is needed. For example, software and infrastructure developers will need to address issues such as variations among patients and may need to find a balance between designing individualised solutions for compliant patients and a safe and easy-to-handle set-up. In addition, proper elucidation of users will contribute to the successful implementation of a left ventricular assist device telemonitoring programme among patients and caregivers. PMID: 31849254 [PubMed - as supplied...
Source: The International Journal of Artificial Organs - December 18, 2019 Category: Transplant Surgery Authors: Walter C, Fischer F, Hanke JS, Dogan G, Schmitto JD, Haverich A, Reiss N, Schmidt T, Hoffmann JD, Feldmann C Tags: Int J Artif Organs Source Type: research

Continuous veno-venous hemofiltration in the treatment of severely burned patients with acute hypernatremia: A retrospective study of 13 cases.
This study aimed to evaluate the clinical effects of continuous veno-venous hemofiltration in the treatment of severely burned patients with acute hypernatremia. METHODS: A total of 13 severely burned patients with acute hypernatremia admitted to Xijing Hospital were included in this study. All patients received continuous veno-venous hemofiltration treatment in addition to conventional treatment. The original sodium level in the replacement fluid was set to be lower than the serum sodium level by 8 mmol/L and subsequently undergoes a reduction rate of 2.16 ± 0.18 mmol/L every 4&thin...
Source: The International Journal of Artificial Organs - December 18, 2019 Category: Transplant Surgery Authors: Huang C, Liu Y, Li L, Liu H, Zhang P Tags: Int J Artif Organs Source Type: research

Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach.
CONCLUSION: Apical right ventricular strain as well as right atrial strain provides complementary information, both critical to predict acute-right ventricular failure and chronic-right ventricular failure, respectively. PMID: 31830841 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 12, 2019 Category: Transplant Surgery Authors: Bellavia D, Iacovoni A, Agnese V, Falletta C, Coronnello C, Pasta S, Novo G, di Gesaro G, Senni M, Maalouf J, Sciacca S, Pilato M, Simon M, Clemenza F, Gorcsan SJ Tags: Int J Artif Organs Source Type: research

A design of brain port with a built-in bi-directional check valve improves the ventriculostomy.
Abstract The increase of intracranial pressure is a life-threatening condition which requires urgent treatment to prevent the further neurologic problem. A design of the brain port is proposed, in which a bi-directional check valve controls the flow of the cerebrospinal fluid depending on the intracranial pressure in accordance with the other devices. Drug administration and cerebrospinal fluid drainage could be performed easily without any additional surgery other than the transplant of a brain port. The intracranial pressure value at which the cerebrospinal fluid should be drained is adjustable by altering the p...
Source: The International Journal of Artificial Organs - December 10, 2019 Category: Transplant Surgery Authors: Chung T, Yoon KC, Kim KG, Lee SH, Yoo H Tags: Int J Artif Organs Source Type: research

Ankle-foot orthosis design between the tradition and the computerized perspectives.
This study focuses on the drop foot case related to hyperthyroidism of the ankle joint resulting in the relaxation of the toes during walking. This condition requires treatment using an ankle-foot orthosis. Traditional orthosis techniques lack precision and depend on the skill of the fabricator. This research aims to make a bias in ankle-foot orthosis design and analysis methods, where a complete methodology of numerical design and testing has been proposed using advanced engineering software. A numerical model of the patient's foot was generated and used to design an ankle-foot orthosis model using SolidWorks. The designe...
Source: The International Journal of Artificial Organs - November 29, 2019 Category: Transplant Surgery Authors: Darwich A, Nazha H, Sliman A, Abbas W Tags: Int J Artif Organs Source Type: research

Effects of long-term aerobic training and detraining on functional capacity and quality of life in hemodialysis patients: A pilot study.
Abstract Although previous studies have shown the benefits of exercise training in hemodialysis patients, little is known about the effects of long-term of exercise program on these patients. We investigated the effects and the safety of long-term aerobic training and the effects of detraining on functional capacity and quality of life in hemodialysis patients. Ten patients were allocated to two groups: training and detraining. The training group completed at least 30 months of aerobic training, and the detraining group completed at least 20 months and then discontinued the training for at least 10&t...
Source: The International Journal of Artificial Organs - November 27, 2019 Category: Transplant Surgery Authors: Gravina EPL, Pinheiro BV, da Silva Jesus LA, da Silva LP, da Silva RN, Silva K, de Paula RB, Reboredo MM Tags: Int J Artif Organs Source Type: research

Exogenous supplementation of antithrombin III in adult and pediatric patients receiving extracorporeal membrane oxygenation.
CONCLUSION: Administration of antithrombin III improved anti-Xa levels in both populations, however, did not significantly reduce heparin rates. Our findings suggest that the use of antithrombin III restores heparin responsiveness in patients with low antithrombin III activity and low anti-Xa activity. PMID: 31750755 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 21, 2019 Category: Transplant Surgery Authors: Sorial MN, Greene RA, Zullo AR, Berard-Collins C, Willis S Tags: Int J Artif Organs Source Type: research

Three-dimensional printing technologies in the fabrication of maxillofacial prosthesis: A case report.
CONCLUSIONS: Three-dimensional printing technology was used for the fabrication of the patient's missing ear. This method eliminated the conventional laboratory steps and reduced the number of stages of the fabrication of a silicone prosthesis. The negative mold of the defect side allowed us a direct fabrication of the silicone prosthesis without a need for waxing or flasking procedures. PMID: 31739725 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 18, 2019 Category: Transplant Surgery Authors: Cevik P, Kocacikli M Tags: Int J Artif Organs Source Type: research

Treatment of patients with cervical and upper thoracic incomplete spinal cord injury using repetitive transcranial magnetic stimulation.
CONCLUSION: Proposed repetitive transcranial magnetic stimulation algorithm reduced the increased muscle tension in upper extremity muscles, improved the function of upper extremity muscle motor units and slightly improved the transmission of efferent neural impulses within spinal pathways. Besides functional recovery in descending spinal pathways, repetitive transcranial magnetic stimulation may also inhibit inevitable pathological changes in nerves. PMID: 31714170 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 12, 2019 Category: Transplant Surgery Authors: Leszczyńska K, Wincek A, Fortuna W, Huber J, Łukaszek J, Okurowski S, Chmielak K, Tabakow P Tags: Int J Artif Organs Source Type: research

Platelet adhesion emulation: A novel method for estimating the device thrombosis potential of a ventricular assist device.
Abstract Device thrombosis inside ventricular assist devices remains a limitation to their long-term clinical use. Thrombosis potential exists in almost all ventricular assist devices because the device-induced high shear stress and vortices can activate platelets, which then aggregate and adhere to the surfaces inside the ventricular assist device. To decrease the device thrombosis potential of long-term use of ventricular assist devices, a methodology entitled platelet adhesion emulation for predicting the thrombosis potential and thrombosis position inside the ventricular assist devices is developed. The platel...
Source: The International Journal of Artificial Organs - November 11, 2019 Category: Transplant Surgery Authors: Liu GM, Chen HB, Hou JF, Zhang Y, Hu SS Tags: Int J Artif Organs Source Type: research

A prolonged and successful heparin-free extracorporeal membrane oxygenation run in isolated thoracic trauma: A case report.
Abstract A 21-year-old patient has been treated in emergency with venovenous extracorporeal membrane oxygenation after severe thoracic trauma causing severe air leak and haemothorax. The extracorporeal assistance was managed without heparin for 10 days till the full recovery of the lung, and no side-effect was recorded. PMID: 31702412 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 8, 2019 Category: Transplant Surgery Authors: Lorini FL, Grazioli L, Manfredi R, Rausa E, Ghitti D, Poli G, Peck M, Cattaneo S Tags: Int J Artif Organs Source Type: research

Clinical outcomes associated with sedation and analgesia in patients supported with venoarterial extracorporeal membrane oxygenation.
Abstract Sedatives and analgesics are frequently used in critically ill adult patients requiring mechanical ventilation in the intensive care unit, but optimal agent selection and dosing in patients supported with venoarterial extracorporeal membrane oxygenation remain poorly defined. This retrospective study evaluated whether sedative and analgesic agent selection and dosing had any impact on clinical outcomes after venoarterial extracorporeal membrane oxygenation decannulation. The primary endpoint of our study was the incidence of delirium within 48 h after venoarterial extracorporeal membrane oxygenatio...
Source: The International Journal of Artificial Organs - November 7, 2019 Category: Transplant Surgery Authors: Skelton PA, Lillyblad MP, Eckman PM, Samara MA, Williams DM, Wilson KJ, Stanberry LI, Hryniewicz KM Tags: Int J Artif Organs Source Type: research

Intrathoracic retention of insoluble hyaluronic acid and its absorption process in rats.
CONCLUSION: This study clarified the time-dependent degradation process and remnants of insoluble hyaluronic acid in the thoracic cavity. A close relationship between the intrathoracic remnant of insoluble hyaluronic acid and its morphological change associated with degradation was demonstrated. PMID: 31692411 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 6, 2019 Category: Transplant Surgery Authors: Uemura A, Ogawa S, Tanaka R Tags: Int J Artif Organs Source Type: research

An experimental model of veno-venous arterial extracorporeal membrane oxygenation.
CONCLUSION: Our computational spreadsheet identifies the suitable cannula pairing set for correctly splitting the outlet blood flow into the arterial and venous return cannulas in a veno-venous arterial extracorporeal membrane oxygenation configuration without the use of external throttles. Several limitations were reported regarding fixed aortic impedance, central venous pressure and the types of cannulas tested; therefore, further studies are mandatory to confirm our findings. PMID: 31692415 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 6, 2019 Category: Transplant Surgery Authors: Belliato M, Caneva L, Aina A, Degani A, Mongodi S, Prahl Wittberg L, Pellegrini C, Broman LM, Iotti GA Tags: Int J Artif Organs Source Type: research

Study on in vitro performance verification protocol for left ventricular assist device.
CONCLUSION: To date, all left ventricular assist devices made in China have been evaluated according this protocol and some of them have entered the clinical trial stage. We are closely observing the clinical data in order to further improve the performance of the platform and encourage more advances in mechanical circulatory assist devices. PMID: 31680606 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 4, 2019 Category: Transplant Surgery Authors: Li S, Hsu PL, Hao Y, Ren H Tags: Int J Artif Organs Source Type: research

Inter-leg systolic blood pressure difference predicts cardiovascular events and mortality in incident hemodialysis patients.
Abstract BACKGROUND: High inter-arm blood pressure difference, a marker of vascular disease, may be difficult to assess in hemodialysis patients with arm arteriovenous fistulae. We investigated if high inter-leg systolic blood pressure difference associates with cardiovascular events and increased mortality in hemodialysis patients. METHODS: Among 118 incident Japanese dialysis patients, bilateral leg blood pressure, arm blood pressure, brachial-ankle pulse wave velocity, and ankle-brachial index were measured, and the relative risk associated with inter-leg systolic blood pressure difference and other indice...
Source: The International Journal of Artificial Organs - November 4, 2019 Category: Transplant Surgery Authors: Kato S, Lindholm B, Qureshi AR, Mukai H, Yuzawa Y, Maruyama S Tags: Int J Artif Organs Source Type: research

Whole blood platelet aggregation kinetics under cardiopulmonary bypass: A pilot study.
This study used multiple electrode impedance aggregometry (Multiplate®) to create a timeline of platelet aggregation changes as induced by cardiopulmonary bypass in antiplatelet-naive patients undergoing elective surgery for mitral valve regurgitation. We performed six consecutive measurements (T1: pre-operatively, T2: after heparinization, T3: 3 min after establishment of cardiopulmonary bypass, T4: immediately after administration of cardioplegia, T5: 5 min after administration of cardioplegia, and T6: 45 min after administration of cardioplegia). Platelet aggregation was determined after stimula...
Source: The International Journal of Artificial Organs - November 1, 2019 Category: Transplant Surgery Authors: Petzold T, Bagaev E, Herzog H, Born F, Hoechter D, Michel S, Rutkowski S, Lüsebrink E, Thienel M, Massberg S, Hagl C, Guenther SP Tags: Int J Artif Organs Source Type: research

Clinical research on individualized hemodialysis preventing unconventional hypotension in diabetic nephropathy patient.
This study aims to evaluate the effectiveness of individualized hemodialysis for unconventional hypotension in diabetic nephropathy patients. METHODS: A total of 60 patients were selected and randomly divided into study group and control group. The control group used the standard dialysis model, while the study group used the individualized hemodialysis scheme, in which the dialysis was performed using an individualized dialysis machine temperature control, pattern of natrium, and pattern of step ultrafiltration in combination with dialysate-containing glucose. RESULTS: The total occurrence rate of hypotension, d...
Source: The International Journal of Artificial Organs - October 30, 2019 Category: Transplant Surgery Authors: Li WH, Yin YM, Chen H, Rui ZR, Yuan Y, Yun H, Wang JW Tags: Int J Artif Organs Source Type: research

A surgical girdle postoperatively may prevent pain and tunnel infections of peritoneal dialysis patients.
This study investigated whether patients benefit from the use of a surgical girdle and specific dressing postoperatively to prevent pain and tunnel infections. MATERIALS AND METHODS: In 85 consecutive patients, the development of tunnel infections was followed. The patients used a surgical girdle when they were in supine position from day 1 to day 3. The peritoneal dialysis catheter was fixed in a curvature avoiding stretch in the exit. A total of 53 patients participated in a retrospective questionnaire to evaluate abdominal pain within the first 3 days after surgery either with or without girdle. A visual ana...
Source: The International Journal of Artificial Organs - October 24, 2019 Category: Transplant Surgery Authors: Nilsson C, Sperker W, Schied C, Isaksson M, Stegmayr BG Tags: Int J Artif Organs Source Type: research

Causes and predictors of 30-day readmissions in patients with cardiogenic shock requiring extracorporeal membrane oxygenation support.
CONCLUSION: Patients with cardiogenic shock who underwent extracorporeal membrane oxygenation had a readmission rate. Identifying patients at high risk of readmissions might help improve outcomes. PMID: 31642373 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 23, 2019 Category: Transplant Surgery Authors: Tashtish N, Al-Kindi SG, Karnib M, Zanath E, Mitchell S, Di Felice C, Zacharias M, Oliveira GH, Medalion B, Lytle F, Elamm C Tags: Int J Artif Organs Source Type: research

Exercise-induced hypoxemia predicts heart failure hospitalization and death in patients supported with left ventricular assist devices.
This study evaluated patients supported by continuous-flow left ventricular assist devices who were invasively monitored during exercise to define parameters that underpin exercise capacity and outcomes. A review of all patients supported by continuous-flow left ventricular assist devices who underwent supine bicycle ergometry exercise testing with measurement of pulmonary gas exchange during right heart catheterization for evaluation of dyspnea at one institution between 2007 and 2018 was performed (n = 22). The primary outcome of this investigation was death or heart failure hospitalization. Although restin...
Source: The International Journal of Artificial Organs - October 19, 2019 Category: Transplant Surgery Authors: Koerber DM, Rosenbaum AN, Olson TP, Kushwaha S, Stulak J, Maltais S, Behfar A Tags: Int J Artif Organs Source Type: research

Endovascular therapy for hemodialysis patients with atrial fibrillation and cerebral thromboembolism: A case series.
CONCLUSION: In this series, endovascular therapy showed good results without complications. More cases should be investigated to obtain more evidence of successful endovascular therapy for hemodialysis patients. PMID: 31623507 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 17, 2019 Category: Transplant Surgery Authors: Kamijo M, Hayashi W, Otsuka E, Obata Y, Sahara N, Takemoto K, Sakamoto S, Ueki Y, Nishino T Tags: Int J Artif Organs Source Type: research

Improved outcomes in neonates who require venoarterial extracorporeal membrane oxygenation after the Norwood procedure.
CONCLUSION: In our cohort of children who received venoarterial extracorporeal membrane oxygenation after the Norwood procedure, hospital survival was improved compared to historical data. In addition, venoarterial extracorporeal membrane oxygenation utilization was not independently associated with worse outcomes. PMID: 31623516 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 17, 2019 Category: Transplant Surgery Authors: De Jesus-Brugman N, Hobson MJ, Herrmann JL, Friedman ML, Cordes T, Mastropietro CW Tags: Int J Artif Organs Source Type: research