Development of exercise-related values in heart failure patients supported with a left ventricular assist device.
Abstract Following implantation of a left ventricular assist device, the build-up and long-term maintenance of adequate exercise capacity and functional performance become crucial. The aim of this study was to observe the development of exercise-related values at different times, as well as to detect possible influencing factors. We performed a prospective single-centre study: 10 patients (63 years, 100% male, body mass index = 27.5, 100% HeartWare) underwent the following diagnostic tests during cardiac rehabilitation and during two subsequent ambulatory visits: 6-min walking test, handgrip s...
Source: The International Journal of Artificial Organs - December 6, 2018 Category: Transplant Surgery Authors: Schmidt T, Bjarnason-Wehrens B, Mommertz S, Schulte-Eistrup S, Willemsen D, Sindermann J, Predel HG, Reiss N Tags: Int J Artif Organs Source Type: research

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer.
Abstract OBJECTIVE:: Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter. METHODS:: Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5 min, antithrombin activity every 40 min, and thrombin-antithrombin complex every...
Source: The International Journal of Artificial Organs - November 29, 2018 Category: Transplant Surgery Authors: Tagaya M, Hara K, Takahashi S, Nagoshi S, Handa H, Okano S, Murataka T Tags: Int J Artif Organs Source Type: research

Development of a simvastatin loaded injectable porous scaffold in situ formed by phase inversion method for bone tissue regeneration.
CONCLUSION:: The results demonstrated that release of simvastatin from the injectable scaffolds can have positive effects on osteogenic differentiation of the adipose-derived stem cells. PMID: 30482084 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 28, 2018 Category: Transplant Surgery Authors: Hajihasani Biouki M, Mobedi H, Karkhaneh A, Daliri Joupari M Tags: Int J Artif Organs Source Type: research

Successful decellularization of thick-walled tissue: Highlighting pitfalls and the need for a multifactorial approach.
CONCLUSION:: In this study, we developed a procedure that grants successful decellularization of porcine aortic wall while maintaining the fibrous microstructure. We highlighted the significant effect of DNase and α-galactosidase treatment. In addition, we could show the need for a multifactorial treatment and comprehensive evaluation protocols for thick tissue decellularization. PMID: 30442045 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 16, 2018 Category: Transplant Surgery Authors: Koenig F, Kilzer M, Hagl C, Thierfelder N Tags: Int J Artif Organs Source Type: research

A new dynamic model for in vitro evaluation of intravascular devices.
DISCUSSION:: A dynamic model for intravascular catheter testing mimics better clinical conditions when evaluating blood-material interaction. Catheter position, blood flow around the catheter, and infusion fluid all have a potential impact on the hemocompatibility of a given catheter. PMID: 30394827 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 4, 2018 Category: Transplant Surgery Authors: Baert EJ, Vandersteene J, Dewaele F, Vantilborgh A, Van Roost D, De Somer F Tags: Int J Artif Organs Source Type: research

Impact of setup orientation on blend electrospinning of poly- ε-caprolactone-gelatin scaffolds for vascular tissue engineering.
This article explores the effect of horizontal and vertical setups on blend electrospinning with two polymers having vastly different properties - poly-ε-caprolactone and gelatin, and subsequent effect of the resulting microstructure on viability of seeded cells. METHODS:: Poly-ε-caprolactone and gelatin of varying blend concentrations were electrospun in horizontal and vertical setup orientations. NIH 3T3 fibroblasts were seeded on these scaffolds to assess cell viability changes in accordance with change in microstructure. RESULTS:: Blend electrospinning yielded a heterogeneous microstructure in...
Source: The International Journal of Artificial Organs - November 1, 2018 Category: Transplant Surgery Authors: Suresh S, Gryshkov O, Glasmacher B Tags: Int J Artif Organs Source Type: research

Chondrocytes cultured in silk-based biomaterials maintain function and cell morphology.
CONCLUSION:: Regenerated silk fibroin film was found to be an excellent biomaterial with good cytocompatibility for chondrocytes, because these cells remained functional and maintained normal cell morphology when cultured in silk-based biomaterials. These results suggest that silk-based chondrocyte biomaterial complexes may provide a feasible and functional biomaterial for repairing clinical cartilage defects. PMID: 30376753 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 30, 2018 Category: Transplant Surgery Authors: Ni Y, Jiang Y, Wang K, Shao Z, Chen X, Sun S, Yu H, Li W Tags: Int J Artif Organs Source Type: research

Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis?
CONCLUSION:: We extend the perspective of pump thrombosis secondary to the supraphysiologic shear stress environment of the pump to one of Left Ventricular Assist Device system thrombosis, raising the importance of comprehensive characterization of the different prothrombotic risk factors of the total system as the target to achieve enhanced hemocompatibility and improved clinical outcomes. PMID: 30354870 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 24, 2018 Category: Transplant Surgery Authors: Selmi M, Chiu WC, Chivukula VK, Melisurgo G, Beckman JA, Mahr C, Aliseda A, Votta E, Redaelli A, Slepian MJ, Bluestein D, Pappalardo F, Consolo F Tags: Int J Artif Organs Source Type: research

Characterization and biological properties of a novel synthesized silicon-substituted hydroxyapatite derived from eggshell.
Abstract In the present study, the effect of adding different concentrations of silicon on physical, mechanical and biological properties of a synthesized aqueous precipitated eggshell-derived hydroxyapatite (e-HA) was evaluated. No secondary phases were detected by X-ray diffraction for the specimens e-HA and e-HA containing silicon (Si-e-HAs) before and after heating at 1200°C. A reduction in the crystallite size and a-axis as well as an increase in c-axis was occurred when silicon replacement was happened in the structure of e-HA. The presence of Si-O vibrations and carbonate modes for Si-e-HAs was confirme...
Source: The International Journal of Artificial Organs - October 22, 2018 Category: Transplant Surgery Authors: Asadipour K, Nezafati N, Nourbakhsh MS, Hafezi-Ardakani M, Bohlooli S Tags: Int J Artif Organs Source Type: research

Couette shearing device for the investigation of shear-induced damage of the primary hemostasis by left ventricular assist devices.
DISCUSSION:: With the shearing device, half-sine-wave-shaped shear stress patterns relevant to rotary blood pumps can be achieved with very good repeatability. The proposed damage model could be used to compare and optimize left ventricular assist devices under development. The tests showed a significant decrease in coagulability after only a few repetitions. PMID: 30345868 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 22, 2018 Category: Transplant Surgery Authors: Lommel MA, Goubergrits L, Affeld K, Kertzscher U Tags: Int J Artif Organs Source Type: research

Young ESAO challenges in artificial organs.
PMID: 30278804 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 2, 2018 Category: Transplant Surgery Authors: Molteni A, Mueller M Tags: Int J Artif Organs Source Type: research

Evaluation of pre- and post-dilution continuous veno-venous hemofiltration on leukocyte and platelet function in patients with sepsis.
CONCLUSION: Pre-dilution veno-venous hemofiltration demonstrates superior biocompatibility in terms of decreased leukocyte function and platelet activation in septic shock patients with acute kidney injury. PMID: 30278811 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 2, 2018 Category: Transplant Surgery Authors: Chihara S, Masuda Y, Tatsumi H, Yamakage M Tags: Int J Artif Organs Source Type: research

Does the plasma refilling coefficient change during hemodialysis sessions?
ski J Abstract The filtration coefficient in the Starling equation is an important determinant of plasma refilling during hemodialysis. A method for calculating from clinical data an estimate of the filtration coefficient, called the refilling coefficient, was proposed in the past. The assumption behind this method was that the only drive for refilling is the increase in plasma oncotic pressure, and the remaining Starling forces have negligible effect. The refilling coefficient was observed to decrease during hemodialysis, and this was interpreted as a change in the filtration coefficient. The purpose of our study...
Source: The International Journal of Artificial Organs - October 2, 2018 Category: Transplant Surgery Authors: Pietribiasi M, Wójcik-Załuska A, Załuska W, Waniewski J Tags: Int J Artif Organs Source Type: research

Salvage extracorporeal membrane oxygenation in induction-associated acute respiratory distress syndrome in acute leukemia patients: A case series.
CONCLUSION: Currently, the use of extracorporeal membrane oxygenation in patients with hematologic malignancies who develop severe acute respiratory distress syndrome remains controversial. Although extracorporeal membrane oxygenation in post-allogeneic hematopoietic stem cell transplant is associated with poorer outcomes, our data suggest that salvage extracorporeal membrane oxygenation support is a viable option to manage moderate to severe acute respiratory distress syndrome while completing therapeutic chemotherapy and following in the peri-induction phase of acute leukemia. PMID: 30223700 [PubMed - as supplied by...
Source: The International Journal of Artificial Organs - September 17, 2018 Category: Transplant Surgery Authors: Huprikar NA, Peterson MR, DellaVolpe JD, Sams VG, Lantry JH, Walter RJ, Osswald MB, Chung KK, Mason PE Tags: Int J Artif Organs Source Type: research

Optimal drainage cannula position in dual cannulation for veno-venous extracorporeal membrane oxygenation.
CONCLUSION: With respect to blood oxygenation, the optimal position for the drainage cannula was the upper inferior vena cava. These findings suggested that blood from the superior vena cava, inferior vena cava, and hepatic vein was most efficiently drained in the upper inferior vena cava cannula position. PMID: 30223702 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - September 17, 2018 Category: Transplant Surgery Authors: Togo K, Takewa Y, Katagiri N, Fujii Y, Yamashita AC, Tastumi E Tags: Int J Artif Organs Source Type: research

Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities.
Abstract OBJECTIVE: To investigate associations of sex-age-specific handgrip strength by a dynamometer with all-cause mortality and the percent excess risk explained (%ERE) by comorbidities and nutritional indicators in incident maintenance hemodialysis patients. METHODS: Prospective cohort of 413 adult patients (165 women, 248 men, 299
Source: The International Journal of Artificial Organs - September 11, 2018 Category: Transplant Surgery Authors: Lopes MB, Silva LF, Dantas MA, Matos CM, Lopes GB, Lopes AA Tags: Int J Artif Organs Source Type: research

Tubular vesicopyelostomy for the management of types 2 and 3 (long-segment) ureteric stenosis after kidney transplantation.
In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center. Twenty-eight of these patients underwent tubular vesicopyelostomy operation; 17 male and 11 female patients with a mean age of 45.6 ± 10.5 years. Time to surgical intervention for ur...
Source: The International Journal of Artificial Organs - September 5, 2018 Category: Transplant Surgery Authors: Uslu A, Cayhan VK, Simsek C, Aykas A, Karatas M, Tarcan IC, Okut G, Tatar E Tags: Int J Artif Organs Source Type: research

Normal fluid stresses are prevalent in rotary ventricular assist devices: A computational fluid dynamics analysis.
This study is the first to quantify the fluid stress components in real blood contacting devices. PMID: 30141359 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 24, 2018 Category: Transplant Surgery Authors: Khoo DP, Cookson AN, Gill HS, Fraser KH Tags: Int J Artif Organs Source Type: research

The use of a virtual patient to follow changes in arterial blood gases associated with therapeutic thoracentesis.
CONCLUSION: Therapeutic thoracentesis may cause both an increase and a decrease in PaO2 during the procedure. Pleural pressure decrease, caused by pleural fluid withdrawal, improves the perfusion of atelectatic lung areas. If the rate of recruitment of these areas is low, a lack of ventilation causes the arterial blood oxygen tension to fall. Effective hypoxic pulmonary vasoconstriction may protect against the pulmonary shunt. PMID: 30141367 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 24, 2018 Category: Transplant Surgery Authors: Stecka AM, Gólczewski T, Grabczak EM, Zieliński K, Michnikowski M, Zielińska-Krawczyk M, Korczyński P, Krenke R Tags: Int J Artif Organs Source Type: research

Surface modification of metallic materials designed for a new generation of artificial heart valves.
CONCLUSION: The results indicate that a-C:H-based coatings with the thickness of 110 nm do not induce an immune response and do not influence the origin of platelet microparticle formation; thus, these type of coatings are the most promising for the parts which are planned to withstand blood contact under the high value of shear stress. PMID: 30141371 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 24, 2018 Category: Transplant Surgery Authors: Major R, Gonsior M, Sanak M, Kot M, Kustosz R, Lackner JM Tags: Int J Artif Organs Source Type: research

Visualization of erythrocyte deformation induced by supraphysiological shear stress.
This study clearly showed that the beginning of erythrocytes' morphological abnormality was induced by shear stress. PMID: 30126305 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 21, 2018 Category: Transplant Surgery Authors: Watanabe N, Shimada T, Hakozaki M, Hara R Tags: Int J Artif Organs Source Type: research

Extracorporeal membrane oxygenation in trauma: A single institution experience and review of the literature.
This article identifies a heterogeneous group of trauma patients in extremis who may benefit from extracorporeal membrane oxygenation. METHODS: Data were sourced from the medical records of all patients placed on extracorporeal membrane oxygenation following trauma at a Level I Trauma Center between 1 December 2016 and 1 December 2017. RESULTS: All patients were male (N = 7), mostly with blunt injuries (n = 5), with an average age of 41 years and with an average Injury Severity Scores of 33 (median = 34). Two out of seven patients survived (28.5%). Survivors tended...
Source: The International Journal of Artificial Organs - August 17, 2018 Category: Transplant Surgery Authors: Strumwasser A, Tobin JM, Henry R, Guidry C, Park C, Inaba K, Demetriades D Tags: Int J Artif Organs Source Type: research

Susceptibility of density-fractionated erythrocytes to subhaemolytic mechanical shear stress.
CONCLUSION: Red blood cell populations respond differently to mechanical stimuli: older (more dense) cells are highly susceptible to sublethal mechanical trauma, while cell age (density) does not appear to alter the magnitude of improved cell deformability following low-shear conditioning. PMID: 30073884 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 3, 2018 Category: Transplant Surgery Authors: McNamee AP, Richardson K, Horobin J, Kuck L, Simmonds MJ Tags: Int J Artif Organs Source Type: research

Video capsule endoscopy is safe and effective in suspected small bowel bleeding among left ventricular assist device recipients.
CONCLUSION: Small bowel capsule endoscopy is safe and effective in the investigation of left ventricular assist device associated suspected small bowel bleeding. PMID: 30073890 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 3, 2018 Category: Transplant Surgery Authors: Itskoviz D, Ben Avraham B, Banai H, Avni I, Ben Gal T, Dotan I, Gal E Tags: Int J Artif Organs Source Type: research

Past and future of blood damage modelling in a view of translational research.
Abstract Anatomic pathologies such as stenosed or regurgitating heart valves and artificial organs such as heart assist devices or heart valve prostheses are associated with non-physiological flow. This regime is associated with regions of spatially high-velocity gradients, high-velocity and/or pressure fluctuations as well as neighbouring regions with stagnant flow associated with high residence time. These hemodynamic conditions cause destruction and/or activation of blood components and their accumulation in regions with high residence time. The development of next-generation artificial organs, which allow long...
Source: The International Journal of Artificial Organs - August 3, 2018 Category: Transplant Surgery Authors: Goubergrits L, Kertzscher U, Lommel M Tags: Int J Artif Organs Source Type: research

Methods for determination of stagnation in pneumatic ventricular assist devices.
CONCLUSION: The resulting main vortexes in the central part of the pump chamber and the velocity magnitudes are correlated in both methods, which are complementary and when used together offer better insight into the flow structure inside the ventricular assist device and enable a deeper analysis of the results. PMID: 30073903 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 3, 2018 Category: Transplant Surgery Authors: Obidowski D, Reorowicz P, Witkowski D, Sobczak K, Jóźwik K Tags: Int J Artif Organs Source Type: research

Microhardness and water solubility of expired and non-expired shelf-life composites.
Abstract BACKGROUND: The aim of this study was to determine the Vickers hardness and water solubility of expired and non-expired shelf-life bulk-fill and conventional dental composite material. METHODS: Four different expired (E) (after 6 months) and non-expired (N) shelf-life composite resin materials (Clearfil Majesty ES-2 Enamel, Clearfil Majesty ES-2 Dentin, Tetric N-Ceram Bulk-Fill, and Tetric N-Ceram) were used. For each tested material, seven specimens were prepared and polymerized with a light curing unit. Vickers hardness measurements were made on the top and bottom surfaces. For the water sor...
Source: The International Journal of Artificial Organs - July 30, 2018 Category: Transplant Surgery Authors: Eliguzeloglu Dalkilic E, Donmez N, Kazak M, Duc B, Aslantas A Tags: Int J Artif Organs Source Type: research

Cytotoxicity of long-term denture base materials.
DISCUSSION: Polymerizing acrylic resins under pressure can be an alternative to conventional polymerizing to ensure a faster denture repair while providing similar cell viability values. Heat-cured acrylic resins provide higher cell viability than hard chairside lining materials in a 15-day period. PMID: 30033859 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Çakırbay Tanış M, Akay C, Sevim H Tags: Int J Artif Organs Source Type: research

In vitro study for the evaluation of transluminal aspiration as a novel treatment option for thrombosis in the HeartWare HVAD.
CONCLUSIONS: The aspiration system showed promising results under specific conditions for the treatment of pump thrombosis in an in vitro model. However, further examination, including in vivo experiments, will justify its effectiveness. PMID: 30019601 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Gärtner T, Beropoulis E, Wendl R, Hanke JS, Dogan G, Chatterjee A, Haverich A, Torsello G, Schmitto JD, Bisdas T, Feldmann C Tags: Int J Artif Organs Source Type: research

Experimental investigations of the aerated polymethylmethacrylate-based vertebral cement flow in capillaries.
DISCUSSION: It has been proven that the aeration of the bone cement alters the flow dynamics. Therefore, much more data are required for statistical analysis to validate a mathematical model of the bone cement flow. PMID: 30019610 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Tyfa Z, Witkowski D, Sobczak K, Obidowski D, Jóźwik K Tags: Int J Artif Organs Source Type: research

Toward longitudinal studies of hemodynamically induced vessel wall remodeling.
CONCLUSION: Coupling contrast-free magnetic resonance imaging and high-resolution computational fluid dynamics represents a promising approach to shed more light in the mechanisms of vascular remodeling and can be used for prospective clinical investigations aimed at identifying critical hemodynamic factors contributing to arteriovenous fistula failure. PMID: 29998758 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Bozzetto M, Brambilla P, Rota S, Ene-Iordache B, Sironi S, Remuzzi G, Remuzzi A Tags: Int J Artif Organs Source Type: research

Pressure difference between radial and femoral artery pressure in minimally invasive cardiac surgery using retrograde perfusion.
CONCLUSION: Radial and femoral systolic artery pressure readings can differ significantly in minimally invasive cardiac surgery with retrograde perfusion. Intraoperative arterial pressure management based solely on radial systolic arterial pressure readings should be avoided. PMID: 29998763 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Nakamura Y, Emmanuel S, Shikata F, Shirai C, Ito Y, Kuroda M Tags: Int J Artif Organs Source Type: research

Effect of blade curvature on the hemolytic and hydraulic characteristics of a centrifugal blood pump.
CONCLUSION: Introducing a blade curvature enhanced the hydrodynamic and hemolytic performance compared to the straight-blade configuration for the investigated centrifugal blood pump. The findings of this study provide new insights into centrifugal blood pump design by examining the influence of the blade curvature. PMID: 29998774 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Ozturk C, Aka IB, Lazoglu I Tags: Int J Artif Organs Source Type: research

Predictors of red blood cell transfusion and its association with prognosis in patients undergoing extracorporeal membrane oxygenation.
Abstract PURPOSE: Few data are available on the potential benefits and risks of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation. The aim of this study was to identify the determinants and prognosis of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation, with a special focus on biological parameters during extracorporeal membrane oxygenation treatment. METHODS: We conducted a single-center retrospective cohort study including all consecutive patients who underwent extracorporeal membrane oxygenation between January 2010 and December 2015. ...
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Lo Pinto H, Allyn J, Persichini R, Bouchet B, Brochier G, Martinet O, Brulliard C, Valance D, Delmas B, Braunberger E, Dangers L, Allou N Tags: Int J Artif Organs Source Type: research

One-year experience with ex vivo lung perfusion: Preliminary results from a single center.
CONCLUSION: Ex vivo lung perfusion can safely be used in the evaluation of lungs initially considered not suitable for transplantation. The primary outcome was not negatively affected and normothermic ex vivo lung perfusion is a useful tool to increase the usage of potentially transplantable lungs. PMID: 29976122 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Koch A, Pizanis N, Olbertz C, Abou-Issa O, Taube C, Slama A, Aigner C, Jakob HG, Kamler M Tags: Int J Artif Organs Source Type: research

Ultrastructural changes in red blood cells in aortic dissection patients under extracorporeal circulation: Atomic force microscopy study.
CONCLUSIONS: This study demonstrates that ultrastructural morphological damage occurs to red blood cells membranes due to extracorporeal circulation in aortic dissection patients. In addition, we provided a new parameter (Ra and Rq) to evaluate red blood cell sublethal trauma. PMID: 29976123 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Deng L, Yang H, Meng W, Chen Y, Hu G, Liu H Tags: Int J Artif Organs Source Type: research

Evaluation of the effects of a polyglycolic acid-collagen tube in the regeneration of facial nerve defects in rats.
CONCLUSION: We found that polyglycolic acid-collagen tubes could be applied in facial nerve gap reconstruction. However, further improvements will be necessary to achieve results that are equivalent to those obtained with autografts. PMID: 29976126 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Oatari M, Uehara M, Shimizu F Tags: Int J Artif Organs Source Type: research

Force induced piezoelectric effect of polyvinylidene fluoride and polyvinylidene fluoride-co-trifluoroethylene nanofibrous scaffolds.
This study reports the piezoelectric effect of electrospun polyvinylidene fluoride scaffolds in response to mechanical loading. An impact test machine was used to evaluate the generation of electrical voltage upon application of an impact load. Scaffolds were produced via electrospinning from polyvinylidene fluoride and polyvinylidene fluoride-co-trifluoroethylene with concentrations of 10-20 wt% dissolved in N,N-dimethylformamide (DMF) and acetone (6:4). The structural and thermal properties of scaffolds were analyzed using Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry, respectively....
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Al Halabi F, Gryshkov O, Kuhn AI, Kapralova VM, Glasmacher B Tags: Int J Artif Organs Source Type: research

Development of an automated liver perfusion system: The benefit of a hemofilter.
DISCUSSION: The machine provides the basis of a perfusion system with autonomous controls and the implementation of a hemofilter that enables a more efficient control of hemostasis. Moreover, the developed hardware and software are subjected to further tuning for additional purposes such as pathophysiologic studies, suboptimal grafts recovery, or recellularization of decellularized scaffolds among others. PMID: 29976128 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - July 1, 2018 Category: Transplant Surgery Authors: Gullón L, Gutiérrez-Gutiérrez J, Sánchez Del Arco RT, Rivera A, Fernández I, Del Cañizo JF Tags: Int J Artif Organs Source Type: research

Hemodialysis during cardiopulmonary resuscitation in patients with severe metabolic acidosis.
CONCLUSION: The addition of high-efficiency hemodialysis during cardiopulmonary resuscitation may contribute to the return of spontaneous circulation in patients with severe metabolic acidosis due to intoxication. PMID: 29976124 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - June 1, 2018 Category: Transplant Surgery Authors: Sahutoglu T, Sahutoglu E Tags: Int J Artif Organs Source Type: research

Risk stratification with longitudinal neutrophil to lymphocyte ratio assessment after left ventricular assist device implantation.
Abstract INTRODUCTION: Inflammatory processes are well-characterized risk factors in cardiovascular disease including advanced heart failure. Previous studies have utilized individual white cell subtypes in risk analysis, and a recent study has focused on the efficacy of the neutrophil-to-lymphocyte ratio in evaluating negative outcomes following left ventricular assist device implantation. To investigate the interaction between the left ventricular assist device and white cell counts, we assessed longitudinal changes in neutrophil-to-lymphocyte ratio following left ventricular assist device implantation. MET...
Source: The International Journal of Artificial Organs - June 1, 2018 Category: Transplant Surgery Authors: Bhat G, Yost GL, Ibrahim K, Pappas P, Tatooles A Tags: Int J Artif Organs Source Type: research

Prolonged veno-arterial extracorporeal life support for cardiac failure.
CONCLUSION: Prolonged veno-arterial extracorporeal life support for cardiac failure is feasible with low technical complication rates. Survival rates are acceptable, yet inferior to short-term support. We observed a shift from initial shock-related complications to infections during prolonged support. Since recovery and thus weaning is rather unlikely after a prolonged need for extracorporeal life support, this form of support should be limited to centers offering the full spectrum of interdisciplinary cardiac care including ventricular assist device implantation and transplantation. PMID: 29896993 [PubMed - as suppli...
Source: The International Journal of Artificial Organs - June 1, 2018 Category: Transplant Surgery Authors: Guenther SP, Shudo Y, Hiesinger W, Banerjee D Tags: Int J Artif Organs Source Type: research

Large eddy simulation in a rotary blood pump: Viscous shear stress computation and comparison with unsteady Reynolds-averaged Navier-Stokes simulation.
CONCLUSION: The results show the potential of the large eddy simulation as a high-quality comparative case to check the suitability of a chosen Reynolds-averaged Navier-Stokes setup and turbulence model. Furthermore, the results lead to suggest that large eddy simulations are superior to unsteady Reynolds-averaged Navier-Stokes simulations when instantaneous stresses are applied for the blood damage prediction. PMID: 29898615 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - June 1, 2018 Category: Transplant Surgery Authors: Torner B, Konnigk L, Hallier S, Kumar J, Witte M, Wurm FH Tags: Int J Artif Organs Source Type: research

Hemoadsorption in cardiac shock with biventricular failure and giant-cell myocarditis: A case report.
CONCLUSION: Extracorporeal life support therapy represents a bridging approach to heart transplantation or to cardiac recovery and can be complemented by CytoSorb as an independent therapeutic option. The patient described herein with giant-cell myocarditis and fulminant cardiac failure who received substantial extracorporeal support in combination with CytoSorb hemoadsorption therapy benefited in terms of an improvement of organ function and his inflammatory situation. PMID: 29843541 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Dogan G, Hanke J, Puntigam J, Haverich A, Schmitto JD Tags: Int J Artif Organs Source Type: research

Validation of in vitro assays in three-dimensional human dermal constructs.
Abstract Three-dimensional cell culture systems are urgently needed for cytocompatibility testing of biomaterials. This work aimed at the development of three-dimensional in vitro dermal skin models and their optimization for cytocompatibility evaluation. Initially "murine in vitro dermal construct" based on L929 cells was generated, leading to the development of "human in vitro dermal construct" consisting of normal human dermal fibroblasts in rat tail tendon collagen type I. To assess the viability of the cells, different assays CellTiter-Blue®, RealTime-Glo™ MT, and CellTiter-Glo&r...
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Idrees A, Chiono V, Ciardelli G, Shah S, Viebahn R, Zhang X, Salber J Tags: Int J Artif Organs Source Type: research

Electrospun poly(vinyl) alcohol/collagen nanofibrous scaffold hybridized by graphene oxide for accelerated wound healing.
CONCLUSION: The scaffold with required strength and biocompatibility may be tried as a wound dressing material in large animals after getting necessary approval. PMID: 29843552 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Senthil R, Berly R, Bhargavi Ram T, Gobi N Tags: Int J Artif Organs Source Type: research

Volume status and arterial blood pressures are associated with arterial stiffness in hemodialysis patients.
In this study, we aimed to investigate possible relations of arterial stiffness with volume status determined by bioimpedance analysis and aortic blood pressure parameters. Also, effects of a single hemodialysis session on these parameters were studied. METHODS: A total of 75 hemodialysis patients (M/F: 43/32; mean age: 53 ± 17) were enrolled. Carotid-femoral pulse wave velocity, augmentation index, and aortic pulse pressure were measured by applanation tonometry before and after hemodialysis. Extracellular fluid and total body fluid volumes were determined by bioimpedance analysis. RESULTS: ...
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Erdan A, Ozkok A, Alpay N, Akkaya V, Yildiz A Tags: Int J Artif Organs Source Type: research

Recovery from anthracycline-induced cardiomyopathy with biventricular assist and valve repairs: A case report and literature review.
CONCLUSION: Our case and the literature review highlight potential usefulness of aggressive mechanical biventricular support for cardiac recovery in patients with anthracycline-induced cardiomyopathy. Additional valve surgery and neurohormonal medications may be also promising in such patients with cancer, who are contraindicated for heart transplantation. PMID: 29806528 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Takami Y, Hoshino N, Kato Y, Sakurai Y, Amano K, Higuchi Y, Tochii M, Ishida M, Ishikawa H, Takagi Y, Ozaki Y Tags: Int J Artif Organs Source Type: research

Incorporation of nanoparticles into transplantable decellularized matrices: Applications and challenges.
Abstract Decellularization of tissues can significantly improve regenerative medicine and tissue engineering by producing natural, less immunogenic, three-dimensional, acellular matrices with high biological activity for transplantation. Decellularized matrices retain specific critical components of native tissues such as stem cell niche, various growth factors, and the ability to regenerate in vivo. However, recellularization and functionalization of these matrices remain limited, highlighting the need to improve the characteristics of decellularized matrices. Incorporating nanoparticles into decellularized tissu...
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Saleh TM, Ahmed EA, Yu L, Kwak HH, Hussein KH, Park KM, Kang BJ, Choi KY, Kang KS, Woo HM Tags: Int J Artif Organs Source Type: research

Development and biological validation of a cyclic stretch culture system for the ex vivo engineering of tendons.
CONCLUSION: We designed a pulsatile strain bioreactor for tendon tissue engineering. The in vitro characterization shows a preferential cell alignment at short time points. Prolonged culture time, however, seems to influence negatively on the survival of the cells indicating the need of further optimization concerning the culture conditions and the mechanical stimulation. PMID: 29781355 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - May 1, 2018 Category: Transplant Surgery Authors: Raimondi MT, Laganà M, Conci C, Crestani M, Di Giancamillo A, Gervaso F, Deponti D, Boschetti F, Nava MM, Scandone C, Domeneghini C, Sannino A, Peretti GM Tags: Int J Artif Organs Source Type: research