Impact of anatomical position of the inflow cannula on stroke in patients with left ventricular assist devices.
CONCLUSION: The duct-sep distance to LVDd ratio was associated with the occurrence of stroke, suggesting that inflow cannula position influences the incidence of stroke. PMID: 33472505 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 21, 2021 Category: Transplant Surgery Authors: Takada T, Nishinaka T, Ichihara Y, Saito S, Imamura Y, Kikuchi N, Hattori H, Suzuki A, Ashihara K, Shiga T, Nunoda S, Hagiwara N, Niinami H Tags: Int J Artif Organs Source Type: research

Extracellular vesicles from three dimensional culture of human placental mesenchymal stem cells ameliorated renal ischemia/reperfusion injury.
CONCLUSION: The EVs from 3D culture of hPMSCs have therapeutic potential for I/R-AKI. PMID: 33467948 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 19, 2021 Category: Transplant Surgery Authors: Zhang X, Wang N, Huang Y, Li Y, Li G, Lin Y, Atala AJ, Hou J, Zhao W Tags: Int J Artif Organs Source Type: research

Angiotensin receptor neprilysin inhibitor use in patients with left ventricular assist devices: A single-center experience.
Abstract Though left ventricular assist devices (LVADs) are an increasingly common therapy for ACC/AHA Stage D heart failure, the optimal medical therapy for patients with LVADs is not known. We sought to evaluate the safety and efficacy of angiotensin receptor neprilysin inhibitor (ARNi) therapy in our single center LVAD patient experience. We evaluated patients implanted with LVADs at Columbia University Irving Medical Center between August 2010 and May 2019, and who were treated with an ARNi for at least 3 months. Thirty patients met this criteria. Eighteen (60%) patients transitioned to an ARNi from an ...
Source: The International Journal of Artificial Organs - January 19, 2021 Category: Transplant Surgery Authors: Alishetti S, Braghieri L, Jennings DL, Uriel N, Colombo PC, Yuzefpolskaya M Tags: Int J Artif Organs Source Type: research

Analysis of extracorporeal membrane oxygenation in trauma patients with acute respiratory distress syndrome: A case series.
CONCLUSION: ECMO therapy in polytrauma patients is a safe and effective option, in particular when used early in ARDS treatment. The overall severity of organ failure determined the likelihood of survival rather than the thoracic trauma itself. PMID: 33438507 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 13, 2021 Category: Transplant Surgery Authors: Weidemann F, Decker S, Epping J, Örgel M, Krettek C, Kühn C, Wilhelmi M Tags: Int J Artif Organs Source Type: research

Sequential versus mono double plasma molecular adsorption system in acute-on-chronic liver failures: A propensity-score matched study.
CONCLUSION: For ACLF patients, sequential DPMAS and PE seemed to have a better effect on liver function improvement but provided no survival benefit compared with mono DPMAS. PMID: 33435806 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 12, 2021 Category: Transplant Surgery Authors: Zhang J, Luo H, Han Y, Zhou X Tags: Int J Artif Organs Source Type: research

Feasibility of long-term continuous flow total heart replacement in calves.
CONCLUSION: Biventricular CF VAD implantation permits a viable bovine CFTAH model capable of demonstrating long-term survival. After 30 days of completely nonpulsatile flow, cumulative hemodynamic, clinical, biochemical, and histological analyses were consistent with preserved end-organ function, suggesting previously unreported long-term feasibility of a CFTAH design. PMID: 33423585 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 11, 2021 Category: Transplant Surgery Authors: Baldwin AC, Gemmato CJ, Cohn WE, Frazier OH Tags: Int J Artif Organs Source Type: research

Validation of transcutaneous carbon dioxide monitoring using an artificial lung during adult pulsatile cardiopulmonary bypass.
Abstract Measurements of transcutaneous carbon dioxide (tcCO2) have been used in multiple venues, such as during procedures utilizing jet ventilation, hyperbaric oxygen therapy, as well as both the adult and neo-natal ICUs. However, tcCO2 measurements have not been validated under conditions which utilize an artificial lung, such cardiopulmonary bypass (CPB). The purpose of this study was to (1) validate the use of tcCO2 using an artificial lung during CPB and (2) identify a location for the sensor that would optimize estimation of PaCO2 when compared to the gold standard of blood gas analysis.tcCO2 measurements (...
Source: The International Journal of Artificial Organs - January 9, 2021 Category: Transplant Surgery Authors: Garrison L, Riley JB, Wysocki S, Souai J, Julick H Tags: Int J Artif Organs Source Type: research

Sleep quality and depression in adults with durable left-ventricular assist devices.
This study aimed at describing sleep quality and depression pre and 6 months post LVAD implantation, examining the change in sleep quality and depression over time, and exploring the relationships among sleep quality and depression. An observational research design was used in this study involving 23 patients with LVADs. Patients' demographics, clinical characteristics, subjective and objective sleep data, and depression were collected pre and 6 months post-LVAD implantation hospitalization. Descriptive and inferential statistics were employed in data analysis. We found that poor sleep quality and depression ...
Source: The International Journal of Artificial Organs - December 25, 2020 Category: Transplant Surgery Authors: D'Aoust RF, Antonsdottir I, Budhathoki C, Casida J Tags: Int J Artif Organs Source Type: research

Dynamic motion analysis of impeller for the development of real-time flow rate estimations of a ventricular assist device.
Abstract Implantable ventricular assist devices are used in heart failure therapy. These devices require real-time flow rate estimation for effective mechanical circulatory support. We previously developed a flow rate estimation method using the eccentric position of a magnetically levitated impeller to achieve real-time estimation. However, dynamic motion of the levitated impeller can compromise the method's performance. Therefore, in this study, we investigated the effects of dynamic motion of the levitated impeller on the time resolution and estimation accuracy of the proposed method. The magnetically levitated...
Source: The International Journal of Artificial Organs - December 25, 2020 Category: Transplant Surgery Authors: Shida S, Masuzawa T, Osa M Tags: Int J Artif Organs Source Type: research

Polypropylene oxygenators: Risk of SARS-CoV-2 contamination in the operation theatre?
PMID: 33349093 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 22, 2020 Category: Transplant Surgery Authors: Nigro Neto C, Lineburger EB, Slullitel A Tags: Int J Artif Organs Source Type: research

Interdialytic weight gain of less than 2.5% seems to limit cardiac damage during hemodialysis.
Abstract AIMS: To investigate if a single low-flux HD induces a rise in cardiac biomarkers and if a change in clinical approach may limit such mechanism. MATERIAL AND METHODS: A total of 20 chronic HD patients each underwent three different study-dialyses. Dialyzers (low-flux polysulfone, 1.8 sqm) had been stored either dry or wet (Wet) and the blood level in the venous chamber kept low or high. Laboratory results were measured at baseline, 30 and 180 min, adjusted for the effect of fluid shift. Ultrasound measured microemboli signals (MES) within the return line. RESULTS: Hemodialysis rais...
Source: The International Journal of Artificial Organs - December 18, 2020 Category: Transplant Surgery Authors: Goto J, Forsberg U, Jonsson P, Matsuda K, Nilsson B, Nilsson Ekdahl K, Henein MY, Stegmayr BG Tags: Int J Artif Organs Source Type: research

Postcardiotomy mechanical support in patients with mitral valve prostheses is associated with poor survival.
Abstract AIMS: To elaborate on early survival in patients with mitral valve replacement requiring temporary extracorporeal life support system (ECLS). METHODS: We analyzed survival, significant bleeding, wound infection, and ECLS duration in 421 from 14,400 patients with postoperative need for ECLS from January 2008 to December 2017 at our institution. Finally, patients were stratified according to the type of surgery performed: the mitral group (mitral valve replacement) n = 63 and the control group (any cardiac surgery excluding the mitral valve) n = 358. In order to adjust for p...
Source: The International Journal of Artificial Organs - December 18, 2020 Category: Transplant Surgery Authors: Pingpoh C, Salama A, Diab N, Kreibich M, Puiu P, Martin C, Benk C, Beyersdorf F, Siepe M Tags: Int J Artif Organs Source Type: research

A target-oriented algorithm for maintaining serum calcium stability automatically in regional citrate anticoagulation.
CONCLUSION: We provided a safe algorithm for calculating calcium supplementation doses that could maintain serum calcium stability without additional adjustment during RCA. PMID: 33339480 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 18, 2020 Category: Transplant Surgery Authors: Sheng RM, Zhao WB, Huang LH, Chen JQ, Dai ZJ, Wang XM Tags: Int J Artif Organs Source Type: research

Real-time, non-invasive thrombus detection in an extracorporeal circuit using micro-optical thrombus sensors.
CONCLUSION: Thrombus detection in an extracorporeal circuit using the developed micro-optical sensors was successfully demonstrated in an in vitro test. PMID: 33300399 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 10, 2020 Category: Transplant Surgery Authors: Morita N, Sakota D, Oota-Ishigaki A, Kosaka R, Maruyama O, Nishida M, Kondo K, Takeshita T, Iwasaki W Tags: Int J Artif Organs Source Type: research

Renal replacement therapy in patients on extracorporeal membrane oxygenation support: Who and how.
We describe our experience with both techniques. A total of 68 patients undergoing ECMO support at our institution were retrospectively analyzed. Predictors of renal failure requiring RRT were determined. Patients undergoing RRT via a dialysis catheter were compared with those undergoing RRT via the ECMO circuit. 10 of the 68 patients required RRT support prior to ECMO. Of the remaining 58 patients, 25 (43%) required new RRT support on ECMO. Lower albumin levels and postcardiotomy shock were predictive of new renal failure requiring RRT on ECMO. RRT performed via the ECMO circuit demonstrated similar efficacy as via a dial...
Source: The International Journal of Artificial Organs - December 10, 2020 Category: Transplant Surgery Authors: Worku B, Khin S, Gaudino M, Gambardella I, Iannacone E, Ebrahimi H, Savy S, Voevidko L, Oribabor C, Hadjiangelis N, Desiraju B, Gulkarov I Tags: Int J Artif Organs Source Type: research

Design and numerical simulation for the development of an expandable paediatric heart valve.
Abstract Current paediatric valve replacement options cannot compensate for somatic growth, leading to an obstruction of flow as the child outgrows the prosthesis. This often necessitates an increase in revision surgeries, leading to legacy issues into adulthood. An expandable valve concept was modelled with an inverse relationship between annulus size and height, to retain the leaflet geometry without requiring additional intervention. Parametric design modelling was used to define certain valve parameter aspect ratios in relation to the base radius, Rb, including commissural radius, Rc, valve height, H and coapt...
Source: The International Journal of Artificial Organs - December 10, 2020 Category: Transplant Surgery Authors: Kerr MM, Gourlay T Tags: Int J Artif Organs Source Type: research

Haemoadsorption by CytoSorb ® in patients with acute liver failure: A case series.
Haemoadsorption by CytoSorb® in patients with acute liver failure: A case series. Int J Artif Organs. 2020 Dec 10;:391398820981383 Authors: Tomescu D, Popescu M, David C, Sima R, Dima S Abstract Acute liver failure (ALF) is a life-threatening disease associated with multi-organ failure and increased mortality. Severe inflammation is now considered the main pathophysiological mechanism for organ dysfunction, thus rebalancing pro- and anti- inflammatory cytokines may improve liver function and outcome. The aim of this study was to assess the clinical effects of a haemoadsorption column on biochemica...
Source: The International Journal of Artificial Organs - December 10, 2020 Category: Transplant Surgery Authors: Tomescu D, Popescu M, David C, Sima R, Dima S Tags: Int J Artif Organs Source Type: research

Effectiveness of distal arterial bypass with porcine decellularized vascular graft for treating diabetic lower limb ischemia.
CONCLUSION: Decellularized vascular graft with surface modification for the small-diameter artery reconstruction had good clinical results after 6 months follow-up in three patients with diabetic lower limb ischemia. PMID: 33302779 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 10, 2020 Category: Transplant Surgery Authors: Tong Z, Xu Z, Tong Y, Qi L, Guo L, Guo J, Gu Y Tags: Int J Artif Organs Source Type: research

Improved hand prostheses control for transradial amputees based on hybrid of voice recognition and electromyography.
In this study, a real-time hybrid control system, based on electromyography (EMG) and voice commands (VC) is designed to render the prosthesis more dexterous with the ability to accomplish amputee's daily activities proficiently. The voice and EMG systems were combined in three proposed hybrid strategies, each strategy had different number of movements depending on the combination protocol between voice and EMG control systems. Furthermore, the designed control system might serve a large number of amputees with different amputation levels, and since it has a reasonable cost and be easy to use. The performance of the propos...
Source: The International Journal of Artificial Organs - December 7, 2020 Category: Transplant Surgery Authors: Alkhafaf OS, Wali MK, Al-Timemy AH Tags: Int J Artif Organs Source Type: research

Molecular adsorbent recirculating system (MARS) and continuous veno-venous hemodiafiltration (CVVHDF) for diltiazem removal: An in vitro study.
The objective of the present study was to evaluate the efficacy of the molecular adsorbent recirculating system (MARS) vs continuous veno-venous hemodiafiltration (CVVHDF). Diltiazem poisoning was simulated in a central compartment consisting in a 5L dialysis solute spiked with diltiazem at two different toxic concentrations: 750 and 5000 µg/L. For CVVHDF, mean extraction coefficients (EC = (in concentration - out concentration)/in concentration) were concentration-dependent with a decrease all along the dialysis. At the end of the sessions the mean amounts remaining in the central ...
Source: The International Journal of Artificial Organs - December 1, 2020 Category: Transplant Surgery Authors: Fabresse N, Larabi IA, Lamy E, Mégarbane B, Alvarez JC Tags: Int J Artif Organs Source Type: research

A two-phase flow approach for modeling blood stasis and estimating the thrombosis potential of a ventricular assist device.
This study proposed a novel approach for modeling blood stasis, based on a two-phase flow principle. The locations of blood residual can be tracked over time, so that regions of blood stasis can be identified. The blood stasis in an axial blood pump is simulated under various working conditions, the results agree well with the experimental results. In contrast, conventional hemodynamic metrics such as velocity, time-averaged wall shear stress (TAWSS), and relative residence time (RRT), were contradictory in judging risk of blood stasis and thrombosis, and inconsistent with experimental results. We also found that the pump ...
Source: The International Journal of Artificial Organs - December 1, 2020 Category: Transplant Surgery Authors: Dai WF, Wu P, Liu GM Tags: Int J Artif Organs Source Type: research

Left atrial assist device function at various heart rates using a mock circulation loop.
This study aimed to assess the hemodynamic effects of the LAAD under both normal heart conditions and various diastolic heart failure (DHF) conditions using a mock circulatory loop. A continuous-flow pump that simulates LAAD, was placed between the left atrial (LA) reservoir and a pneumatic ventricle that simulated a native left ventricle on a pulsatile mock loop. Normal heart (NH) and mild, moderate, and severe DHF conditions were simulated by adjusting the diastolic drive pressures of the pneumatic ventricle. With the LAAD running at 3200 rpm, data were collected at 60, 80, and 120 bpm of the pneumatic vent...
Source: The International Journal of Artificial Organs - December 1, 2020 Category: Transplant Surgery Authors: Kado Y, Polakowski AR, Kuban BD, Horvath DJ, Miyamoto T, Karimov JH, Starling RC, Fukamachi K Tags: Int J Artif Organs Source Type: research

Venovenous ECMO treatment, outcomes, and complications in adults according to large case series: A systematic review.
CONCLUSION: This study reveals the characteristics of large case VV ECMO studies. PMID: 33259258 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 1, 2020 Category: Transplant Surgery Authors: Kim JH, Pieri M, Landoni G, Scandroglio AM, Calabrò MG, Fominskiy E, Lembo R, Heo MH, Zangrillo A Tags: Int J Artif Organs Source Type: research

Decellularization of porcine carotid arteries using low-concentration sodium dodecyl sulfate.
CONCLUSION: Low-concentration SDS could be a suitable choice for artery decellularization. Decellularized porcine carotid arteries, prepared using Triton X-100 followed by 0.3% SDS, may be a promising biological scaffold for TEVGs. PMID: 33222583 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 23, 2020 Category: Transplant Surgery Authors: Cheng J, Li J, Cai Z, Xing Y, Wang C, Guo L, Gu Y Tags: Int J Artif Organs Source Type: research

Evaluation of a hospital-wide vancomycin-dosing nomogram in patients with continuous-flow left ventricular assist devices.
Abstract INTRODUCTION: Hemodynamic derangements due to heart failure are associated with alterations in pharmacokinetics. Although use of mechanical circulatory support mitigates such derangements, little evidence is available regarding pharmacokinetics in patients with LVADs. A previous pharmacokinetic analysis of vancomycin among patients with LVADs observed a reduced volume of distribution and clearance compared with estimates based on population kinetics. METHODS: A total of 28 adult patients with LVADs hospitalized between January 2014 and May 2018 who received vancomycin through a pharmacist dosing cons...
Source: The International Journal of Artificial Organs - November 21, 2020 Category: Transplant Surgery Authors: Hall SF, Athans V, Wanek MR, Wang L, Estep JD, Williams B Tags: Int J Artif Organs Source Type: research

Elimination of fluconazole during continuous renal replacement therapy. An in vitro assessment.
CONCLUSION: Neither the ST150®-polyacrylonitrile nor the AV1000®-polysulfone filters result in any significant adsorption of fluconazole. PMID: 33222594 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 21, 2020 Category: Transplant Surgery Authors: Baud FJ, Jullien V, Abarou T, Pilmis B, Raphalen JH, Houzé P, Carli P, Lamhaut L Tags: Int J Artif Organs Source Type: research

An easy disinfection strategy for pipes connecting hemodialysis equipment.
CONCLUSION: A weekly disinfection strategy was more effective than a monthly one, despite the lower hypochlorite concentration. The present study suggests that frequency is the most important factor in the disinfection of pipes in a dialysis room. PMID: 33222595 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 21, 2020 Category: Transplant Surgery Authors: Tagaya M, Oda Y, Kimura A, Irifune R, Okano S, Murataka T, Handa H, Takahashi S Tags: Int J Artif Organs Source Type: research

Finding a proper "Mate": Comparison of left ventricular assist devices using cerebral oximetry.
CONCLUSION: Axial devices resulted in a greater increase in rSO2 than centrifugal pumps after separation from CPB. Further investigation is warranted to evaluate the effect of LVAD selection on long-term end-organ perfusion and subsequent patient outcomes. PMID: 33213260 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 20, 2020 Category: Transplant Surgery Authors: Montgomery ML, Stannard B, Dzedzik S, Lin HM, Anyanwu A, Levin MA, Trinh M Tags: Int J Artif Organs Source Type: research

Circulatory support for prolonged electro-mechanical standstill in fulminant pediatric myocarditis.
We present a case of fulminant myocarditis presenting with dense heart block, no ventricular electrical activity resuscitated with ECMO that developed prolonged cardiac standstill. We present the clinical course, management including ECMO followed by biventricular assist devices, pacing and review supporting literature. We hope that the case will highlight challenges in management and decision making in such patients. PMID: 33183135 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 13, 2020 Category: Transplant Surgery Authors: Deshpande SR, Willett RC, Ramakrishnan K, Peer SM, Sinha P Tags: Int J Artif Organs Source Type: research

Comparison of intra-wound drainage tubes after cardiac surgery: Blake drains versus Multichannel drains.
Abstract BACKGROUND: Blake and Multichannel drains have been used in our department. Although both are made up of silicone, they differ in structure. We investigated the drainage effects of these two types of drains and the factors related to their occlusion. METHODS: We enrolled 100 consecutive cases (50 using Blake drains and 50 using Multichannel drains) of cardiovascular surgery performed in our department from July 2017 to April 2018. The formation of thrombi in the groove and tube of the drains was evaluated in each case. The tube portion was checked for the presence of occlusion, and the groove portion...
Source: The International Journal of Artificial Organs - November 13, 2020 Category: Transplant Surgery Authors: Hirata Y, Tayama E, Ueda T, Uchiyama H, Onzuka T, Furukawa K, Morita S Tags: Int J Artif Organs Source Type: research

Nanocontainers for drug delivery systems: A review of Halloysite nanotubes and their properties.
Abstract Halloysite nanotubes (HNTs) are known as inexpensive and available nanomaterials that are rich in functionality, environmentally benign, and also safe and easy to process. As well, good particle size (i.e. nanoscale) and perfect tubular microstructures of these materials make them to be used extensively as drug carriers. Also, the unique physical and chemical properties of their internal and external surfaces are the greatest priority for the drug encapsulation controlling and releasing. In this review, is tried to emphasis on the main properties of HNTs to manage and develop effective drug delivery tools...
Source: The International Journal of Artificial Organs - November 10, 2020 Category: Transplant Surgery Authors: Hasani M, Abdouss M, Shojaei S Tags: Int J Artif Organs Source Type: research

The effects of age at cochlear implantation on balance in children: A pilot study.
n D Abstract AIM: The evaluation of the effects of age at cochlear implantation on balance in children. RESEARCH DESIGN: Cross-sectional study. STUDY SAMPLE: Twenty children who received their cochlear implants (CI) before the chronologic age of 48 months (Early CI Group), and 20 children who received their CI at 48 months chronologic age or later (Late CI Group). INTERVENTION: All children underwent Tandem Romberg (TR) test, Single-Leg stance (SLS) test, Pediatric Clinical Test of Sensory Interaction for Balance (P-CTSIB), Pediatric Balance scale (PBS) and Timed Up and Go (TUG) test. ...
Source: The International Journal of Artificial Organs - November 3, 2020 Category: Transplant Surgery Authors: Mujdeci B, Önder S, Alluşoğlu S, Boynuegri S, Kum O, Atan D Tags: Int J Artif Organs Source Type: research

Desialylation of platelet surface glycans enhances platelet adhesion to adsorbent polymers for lipoprotein apheresis.
CONCLUSION: Alterations in endogenous neuraminidase activity or exogenous (pathogen-derived) neuraminidase may trigger enhanced platelet adhesion in whole blood lipoprotein apheresis. PMID: 33143534 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 3, 2020 Category: Transplant Surgery Authors: Lauková L, Weiss R, Semak V, Weber V Tags: Int J Artif Organs Source Type: research

Linoleic acid-modified liposomes for the removal of protein-bound toxins: An in vitro study.
CONCLUSION: LA-liposomes were efficient in the clearance of the representative PBUTs and liver failure-related solutes. Moreover, the combination of indirect adsorbent LA-liposomes and competitive displacer suggested a potential application for the extremely highly-bound solutes. PMID: 33135543 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 2, 2020 Category: Transplant Surgery Authors: Shen Y, Shen Y, Bi X, Li J, Chen Y, Zhu Q, Wang Y, Ding F Tags: Int J Artif Organs Source Type: research

More continuous flow, better learning? The effect of aortic valve opening in patients with left ventricular assist device.
CONCLUSION: With continuous-flow LVAD, neurocognitive functions were not impaired. The learning performance was better in cases where there was no AVO and flow was completely device dependent. We may speculate that neurocognitive functions are not worsening with continuous cerebral blood flow and even it may improve learning performance. PMID: 33092432 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 23, 2020 Category: Transplant Surgery Authors: Karahan M, Kocabeyoglu SS, Kervan U, Sert DE, Erdogan Bakar E, Aygun E, Tola M, Demirkan B, Mungan S, Catav Z, Pac M Tags: Int J Artif Organs Source Type: research

Bleeding, thrombosis and transfusion in patients on ECMO: A retrospective study in a tertiary center in Hong Kong.
CONCLUSIONS: Bleeding and thrombosis were common complications in Chinese patients receiving ECMO. Hypofibrinogenemia and bloodstream infection, but not APTT nor platelet counts, were independent risk factors for bleeding events. PMID: 33070679 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 17, 2020 Category: Transplant Surgery Authors: Fong KM, Au SY, Ng GWY, Leung AKH Tags: Int J Artif Organs Source Type: research

Vascular calcification by conventional X-ray and mortality in a cohort of predominantly African descent hemodialysis patients.
CONCLUSION: The present study in an African descent MHD population provides support for the VC score based on conventional radiography as a prediction tool for the clinical practice. As shown, the VC score was monotonically and independently associated with mortality. PMID: 33063583 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 16, 2020 Category: Transplant Surgery Authors: Martins MTS, Matos CM, Lopes MB, Kraychete AC, Lopes GB, Martins MTS, Fernandes JL, Amoedo MK, Neves CL, Lopes AA Tags: Int J Artif Organs Source Type: research

ECCO2R with cytokine filtering in COVID-19 patients: Who wants to go down this road?
PMID: 33063627 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 16, 2020 Category: Transplant Surgery Authors: Condello I, Mastroroberto P, Santarpino G Tags: Int J Artif Organs Source Type: research

Anticoagulation with temporary Impella device in patients with heparin-induced thrombocytopenia: A case series.
Abstract The Impella device is a percutaneous ventricular assist devices that requires administration of heparin via a continuous purge solution. Patients on Impella device support may experience hemolysis with accompanying thrombocytopenia generating suspicion for heparin-induced thrombocytopenia (HIT). However, data and recommendations for use of non-heparin anticoagulants with Impella device are lacking. Therefore, we performed a retrospective cohort analysis of patients requiring bivalirudin during Impella device support to describe the safety and efficacy of bivalirudin as an alternative anticoagulant during ...
Source: The International Journal of Artificial Organs - October 14, 2020 Category: Transplant Surgery Authors: Hohlfelder B, Militello MA, Tong MZ, Soltesz EG, Wanek MR Tags: Int J Artif Organs Source Type: research

Selection of suitable pedicle screw for degenerated cortical and cancellous bone of human lumbar spine: A finite element study.
Abstract Pedicular arthrodesis is the traditional procedure in terms of increase in the biomechanical stability with higher fixation rate. The current work aims to identify the effect of three spinal pedicle screws considering cortical and cancellous degeneracy condition. Lumbar section L2-L3 is utilized and various load and moment conditions were applied to depict the various biomechanical parameters for selection of suitable screw. Three dimensional model is considered in finite element analysis to identify the various responses of pedicle screw at bone screw juncture. Computed tomography (CT) images of a health...
Source: The International Journal of Artificial Organs - October 13, 2020 Category: Transplant Surgery Authors: Jain P, Sing Ngie DC, Lim SF, Lim BH Tags: Int J Artif Organs Source Type: research

Multidisciplinary shock team is associated with improved outcomes in patients undergoing ECPR.
CONCLUSIONS: We demonstrate that adult patients in cardiac arrest initiated on VA ECMO in the cardiac catheterization laboratory and cared for by a multidisciplinary shock team in the critical care unit have superior long-term survival and functionally favorable neurologic recovery when compared to current literature. PMID: 33028139 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 8, 2020 Category: Transplant Surgery Authors: Hryniewicz K, Hart M, Raile D, Wang Y, Mooney M, Mudy K, Eckman PM, Samara MA, Traverse J, Sun B, Williams DM, Wilson KJ, Pavlovec M, Kunz M, Lyon D, Chavez I Tags: Int J Artif Organs Source Type: research

Impacts of age, diabetes, gender, and access type on costs associated with vascular access among Chinese patients on hemodialysis.
CONCLUSION: HD patients aged>75 years had significantly higher annual VA-related costs. However, the annual VA-related costs did not differ across the diabetes groups or the gender groups. AVF was the most cost-effective permanent VA type in China, partly due to the inexpensive materials used compared to AVG or tcCVC. PMID: 33016167 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 3, 2020 Category: Transplant Surgery Authors: Xiong Y, Yu Y, Yang Y, Wang L, Shi P, Deng Y, Li Y, Fu P Tags: Int J Artif Organs Source Type: research

Extracorporeal multiorgan support including CO2-removal with the ADVanced Organ Support (ADVOS) system for COVID-19: A case report.
We report on an 80-year old patient with pulmonary, renal, circulatory, and hepatic failure. We decided against the use of extracorporeal membrane oxygenation (ECMO) due to old age and a SOFA-score of 13. However, the patient was continuously treated with the extracorporeal multi-organ- "ADVanced Organ Support" (ADVOS) device (ADVITOS GmbH, Munich, Germany). During eight 24h-treatment-sessions blood flow (100-300 mL/min), dialysate flow (160-320 mL/min) and dialysate pH (7.6-9.0) were adapted to optimize arterial PaCO2 and pH. Effective CO2 removal and correction of acidosis could be demonstrated by...
Source: The International Journal of Artificial Organs - September 27, 2020 Category: Transplant Surgery Authors: Huber W, Lorenz G, Heilmaier M, Böttcher K, Sahm P, Middelhoff M, Ritzer B, Schulz D, Bekka E, Hesse F, Poszler A, Geisler F, Spinner C, Schmid RM, Lahmer T Tags: Int J Artif Organs Source Type: research

Comparison of small-diameter decellularized scaffolds from the aorta and carotid artery of pigs.
Abstract AIM: Tissue-specific extracellular matrix promotes tissue regeneration and repair. We aimed to identify the optimal decellularized matrices for tissue-engineered vascular graft (TEVG). METHODS: Decellularized aorta of fetal pigs (DAFP, n = 6, group A), decellularized aorta of adult pigs (DAAP, n = 6, group B), and decellularized carotid artery of adult pigs (DCAP, n = 6, group C) were prepared. Scaffolds were compared using histology and ultrastructure. Endothelial cell (EC) and myofibroblast (MFB) infiltration assessments were performed in vitro. Cell infilt...
Source: The International Journal of Artificial Organs - September 27, 2020 Category: Transplant Surgery Authors: He Z, Liu G, Ma X, Yang D, Li Q, Li N Tags: Int J Artif Organs Source Type: research

Enhanced cellular functions of hepatocytes in the hyaluronate-alginate-chitosan microcapsules.
In this study, microcapsules were prepared with hyaluronate (HA)/sodium alginate (SA) as an inner core and an outer chitosan (CS) shell via one-step spraying method. C3A cells were encapsulated in microcapsules to examine the biocompatibility of HA-SA-CS microcapsules. MTT and fluorescence microscopy indicated that C3A cells had high viability in the HA-SA-CS microcapsules. The liver-specific functions, such as urea and albumin synthesis, and CYP1A2 and CYP3A4 activities from encapsulated cells were increased in the HA-SA-CS microcapsules compared to the SA-CS microcapsules. The gene expressions of CYP450 related genes wer...
Source: The International Journal of Artificial Organs - September 23, 2020 Category: Transplant Surgery Authors: Zhang Y, Lu J, Li Z, Zhu D, Yu X, Li L Tags: Int J Artif Organs Source Type: research

The impact of arteriovenous fistulas and tunneled cuffed venous catheters on morbidity and mortality in hemodialysis patients: A single center experience.
This study focuses on the effects of AVFs and tCVCs on morbidity and mortality in hemodialysis patients. METHODS: The records (between January 2015 and January 2017) of 110 patients (55 patients with AVF and 55 patients with tCVC) under hemodialysis therapy for at least 6 months were evaluated retrospectively. The data about blood tests, hospitalizations, and mortality were compared between patients with AVF and tCVC. FINDINGS: Fifty-five patients (25 male, 58 ± 14 years old) were undergoing hemodialysis via AVF. Fifty-five patients (17 male, 63 ± 14 ...
Source: The International Journal of Artificial Organs - September 21, 2020 Category: Transplant Surgery Authors: Celik S, Gok Oguz E, Ulusal Okyay G, Selen T, Ayli MD Tags: Int J Artif Organs Source Type: research

Structural improvement study of streamline design method, conical hub, and auxiliary blades for axial blood pump.
Abstract The blood pump is a medical device used to assist or replace the diseased heart. Research on the structure of blood pumps has been committed to achieving better hemolysis and hydraulic performance. The purpose of this study was to find some effective ways to improve design methods and hydraulic structures. The research contents of improvement include: (1) improved blade streamline design method; (2) conical impeller hub; (3) additional auxiliary blades. Characteristic analysis and parameter design were carried out on the above three aspects. The methods used in this study included Dynamics (CFD) simulatio...
Source: The International Journal of Artificial Organs - September 20, 2020 Category: Transplant Surgery Authors: Yu Z, Tan J, Wang S, Guo B Tags: Int J Artif Organs Source Type: research

Cell-derived decellularized extracellular matrix scaffolds for articular cartilage repair.
Abstract Articular cartilage repair remains a great clinical challenge. Tissue engineering approaches based on decellularized extracellular matrix (dECM) scaffolds show promise for facilitating articular cartilage repair. Traditional regenerative approaches currently used in clinical practice, such as microfracture, mosaicplasty, and autologous chondrocyte implantation, can improve cartilage repair and show therapeutic effect to some degree; however, the long-term curative effect is suboptimal. As dECM prepared by proper decellularization procedures is a biodegradable material, which provides space for regeneratio...
Source: The International Journal of Artificial Organs - September 17, 2020 Category: Transplant Surgery Authors: Zhu W, Cao L, Song C, Pang Z, Jiang H, Guo C Tags: Int J Artif Organs Source Type: research

Association between splenic volume and pulsatility index in patients with left ventricular assist devices.
Abstract The spleen serves as a blood volume reservoir for systemic volume regulation in heart failure (HF) patients. Changes are seen in spleen size in advanced HF patients after left ventricular assist device (LVAD) implantation. The pulsatility index (PI) is an indicator of native heart contractility with hemodynamic changes in patients using LVAD. We hypothesized that the splenic volume was associated with the PI, reflecting the hemodynamics in advanced HF patients with LVADs. Herein, we investigated the relationship between splenic volume and PI in these patients. Forty-four patients with advanced HF underwen...
Source: The International Journal of Artificial Organs - September 11, 2020 Category: Transplant Surgery Authors: Hiraiwa H, Okumura T, Sawamura A, Kondo T, Kazama S, Kimura Y, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Furusawa K, Morimoto R, Fujimoto K, Mutsuga M, Usui A, Murohara T Tags: Int J Artif Organs Source Type: research

Intermittent hemodiafiltration as a down-step transition therapy in patients with acute kidney injury admitted to intensive care unit who initially underwent continuous venovenous hemodiafiltration.
CONCLUSION: Hemodiafiltration was safe and efficient to treat critically ill patients with acute kidney injury during the transition phase from continuous to intermittent dialysis modality. Special attention should be paid regarding the occurrence of electrolytic disturbance, mainly hypophosphatemia. PMID: 32907438 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - September 9, 2020 Category: Transplant Surgery Authors: Scherer PF, Iizuka IJ, Ammirati AL, Doher MP, Matsui TN, Dos Santos BFC, Monte JCM, Batista MC, Pereira VG, Dos Santos OFP, Durão MS Tags: Int J Artif Organs Source Type: research