CytoSorb ® hemoadsorption and mechanical circulatory support in a newborn with refractory shock after congenital heart surgery.
We report the case of a newborn with cardiogenic and vasoplegic shock secondary to cardiopulmonary bypass for atrioseptostomy and prostaglandin treatment in the context of hypoplastic left heart syndrome, successfully treated with a combination of mechanical circulatory support and cytokine hemoadsorption column (CytoSorb®). Vasopressor support was weaned during the time of treatment without multiple organ failure occurrence. The use of CytoSorb® cartridge inserted in an extra-corporeal circuit even in a newborn is easy and feasible, as long as some precautions are considered. Routine monitoring of drugs levels is ...
Source: The International Journal of Artificial Organs - April 10, 2019 Category: Transplant Surgery Authors: Perez MH, Maitre G, Longchamp D, Amiet V, Natterer J, Ferry T, Schneider A, Plaza Wuthrich S, Di Bernardo S Tags: Int J Artif Organs Source Type: research

Tissue engineering in periodontology: Biological mediators for periodontal regeneration.
Abstract Teeth and the periodontal tissues represent a highly specialized functional system. When periodontal disease occurs, the periodontal complex, composed by alveolar bone, root cementum, periodontal ligament, and gingiva, can be lost. Periodontal regenerative medicine aims at recovering damaged periodontal tissues and their functions by different means, including the interaction of bioactive molecules, cells, and scaffolds. The application of growth factors, in particular, into periodontal defects has shown encouraging effects, driving the wound healing toward the full, multi-tissue periodontal regeneration,...
Source: The International Journal of Artificial Organs - April 2, 2019 Category: Transplant Surgery Authors: Carmagnola D, Pellegrini G, Dellavia C, Rimondini L, Varoni E Tags: Int J Artif Organs Source Type: research

Additional hemoperfusion is associated with improved overall survival and self-reported sleep disturbance in patients on hemodialysis.
In this study, we attempted to explore whether long-term hemoperfusion could improve sleep and increase the overall survival in hemodialysis patients. METHODS:: A total of 158 patients, who underwent routine hemodialysis, were assessed in this study. These patients were computer-matched into two groups, with one group including 80 patients with absolute hemodialysis and the other consisting of 78 cases with hemodialysis in combination with hemoperfusion. Hemoperfusion was performed 1-2 times biweekly, with each session lasting 2 h. Self-reported sleep disturbance was evaluated before and after the observational...
Source: The International Journal of Artificial Organs - March 28, 2019 Category: Transplant Surgery Authors: Gu YH, Yang XH, Pan LH, Zhan XL, Guo LL, Jin HM Tags: Int J Artif Organs Source Type: research

Impact of preoperative extracorporeal life support on left ventricular assist device outcomes: A comparative study.
Abstract BACKGROUND:: To investigate whether preoperative short-term extracorporeal life support therapy in patients undergoing continuous-flow left ventricular assist device implantation has an impact on the outcome regarding survival and adverse events. METHODS:: Between January 2011 and May 2018, 100 consecutive patients received HeartMate II, HeartWare, or HeartMate III for end-stage heart failure. Mean age was 64.2 ± 10.3 years. Three patient groups were identified: without preoperative extracorporeal life support (non-extracorporeal life support group, n = 80), ...
Source: The International Journal of Artificial Organs - March 28, 2019 Category: Transplant Surgery Authors: Zhigalov K, Szczechowicz M, Mashhour A, Mkalaluh S, Safonov D, Enginoev S, Easo J, Ennker J, Eichstaedt HC, Weymann A Tags: Int J Artif Organs Source Type: research

Hemoadsorption in isolated conjugated hyperbilirubinemia after extracorporeal membrane oxygenation support. Cholestasis of sepsis: A case report and review of the literature on differential causes of jaundice in ICU patient.
Abstract Hyperbilirubinemia occurs in up to 40% of critically ill. In ICU, hyperbilirubinemia is an independent factor that influences patients' morbidity and mortality. Jaundice can reflect the course of disease or be caused by treatment (e.g. extracorporeal membrane oxygenation (ECMO)), thus can be difficult to differentiate. Sepsis was also associated with development of jaundice secondary to intrahepatic cholestasis. Prolonged cholestasis should be addressed to avoid liver damage. The patient with diagnosis of septic shock and severe acute respiratory distress syndrome was retrieved to our hospital for ECMO. T...
Source: The International Journal of Artificial Organs - March 28, 2019 Category: Transplant Surgery Authors: Piwowarczyk P, Kutnik P, Potręć-Studzińska B, Sysiak-Sławecka J, Rypulak E, Borys M, Czczuwar M Tags: Int J Artif Organs Source Type: research

Bone repair scaffold coated with bone morphogenetic protein-2 for bone regeneration in murine calvarial defect model: Systematic review and quality evaluation.
Abstract To systematically assess the effects of hydroxyapatite bone repair scaffold coated with bone morphogenetic protein-2 on murine calvarial defect models and to determine the quality of studies according to the Animal Research Reporting in In Vivo Experiments guidelines. Internet search was performed in duplicate using PubMed, MEDLINE, Ovid and Embase databases (without restrictions on publication date). The Animal Research Reporting in In Vivo Experiments guidelines were used to evaluate the quality of selected studies. Following screening, 12 studies were eligible for the review. Studies with average quali...
Source: The International Journal of Artificial Organs - March 25, 2019 Category: Transplant Surgery Authors: Zeng JH, Qiu P, Xiong L, Liu SW, Ding LH, Xiong SL, Li JT, Xiao ZB, Zhang T Tags: Int J Artif Organs Source Type: research

Solutes removal characteristics at various effluent rates during different continuous renal replacement therapy modalities.
This study aims at testing whether the effluent, represented by mL/kg/h, could measure solute clearance and whether increasing effluent increases clearance proportionately in continuous hemodialysis or hemofiltration. METHODS:: Patients treated with continuous renal replacement therapy for various diagnoses were included. The range of dialysate flow rate or substitution fluid flow rate was 1-5 L/h; solutes in the effluent and in the plasma entering the filter were measured, and the ratio of solutes in the effluent and in the plasma entering the filter and the clearance of blood urea nitrogen, creatinine, phosph...
Source: The International Journal of Artificial Organs - March 25, 2019 Category: Transplant Surgery Authors: Yu W, Zhuang F, Ma S, Zhu M, Ding F Tags: Int J Artif Organs Source Type: research

Noninvasive assessment of blood pressure in rotary blood pump recipients using a novel ultrasonic Doppler method.
In this study, a new Doppler blood pressure measurement system was developed and clinically validated. The novel sensor allows easier placement above the radial artery compared to commercial probes. An algorithm was developed which processes the Doppler signal robustly and is able to determine the systolic as well as the mean arterial blood pressure. PMID: 30854909 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - March 11, 2019 Category: Transplant Surgery Authors: Granegger M, Thamsen B, Moscato F, Schlöglhofer T, Gross C, Schneider S, Röhrich M, Kertzscher U, Zimpfer D, Affeld K, Schima H Tags: Int J Artif Organs Source Type: research

Flow rate estimation of a centrifugal blood pump using the passively stabilized eccentric position of a magnetically levitated impeller.
Abstract Flow rate estimation for ventricular assist devices without additional flow sensors can improve the quality of life of patients. In this article, a novel flow estimation method using the passively stabilized displacement of a magnetically levitated impeller is developed to achieve sufficient accuracy and precision of flow estimation for ventricular assist devices in a simple manner. The magnetically levitated impeller used is axially suspended by a magnetic bearing in a centrifugal blood pump that has been developed by our group. The radial displacement of the impeller, which is restricted by passive stab...
Source: The International Journal of Artificial Organs - March 11, 2019 Category: Transplant Surgery Authors: Shida S, Masuzawa T, Osa M Tags: Int J Artif Organs Source Type: research

Tissue-engineered solution containing cells and biomaterials-an in vitro study: A perspective as a novel therapeutic application.
This study tested the efficiency of tissue-engineered solution containing human malignant melanoma cell line (HMV-II) and different biomaterials, including Cellprene®, Membracel®, and poly lactic-co-glycolic acid/epoxidized polyisoprene. The cells adhered better on poly lactic-co-glycolic acid/epoxidized polyisoprene, and it was found that tissue-engineered solution may also contain mesenchymal stem cells cultivated on poly lactic-co-glycolic acid/epoxidized polyisoprene. Histological, immunofluorescence, and scanning electron microscopy analyses were performed. These initial in vitro results suggest that tissue-en...
Source: The International Journal of Artificial Organs - March 6, 2019 Category: Transplant Surgery Authors: Henckes NAC, Festa JCD, Faleiro D, Medeiros HR, Guerra NB, Dos Santos LAL, Terraciano PB, Passos EP, de Oliveira FDS, Cirne-Lima EO Tags: Int J Artif Organs Source Type: research

Propofol-based sedation does not negatively influence oxygenator running time compared to midazolam in patients with extracorporeal membrane oxygenation.
CONCLUSION:: The use of propofol as sedative seems suitable in patients undergoing extracorporeal membrane oxygenation therapy. PMID: 30819020 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - February 28, 2019 Category: Transplant Surgery Authors: Lamm W, Nagler B, Hermann A, Robak O, Schellongowski P, Buchtele N, Bojic A, Schmid M, Zauner C, Heinz G, Ullrich R, Staudinger T Tags: Int J Artif Organs Source Type: research

Clindamycin clearance during Cytosorb ® hemoadsorption: A case report and pharmacokinetic study.
We report the case of a 14-year-old patient with Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus infection and Influenza B pneumonia requiring veno-arterial extra-corporeal membrane oxygenator for refractory shock. In the absence of response to conventional therapy, we have inserted a Cytosorb® cartridge within the extra-corporeal membrane oxygenator circuit. A spectacular decrease in vasopressor requirements followed. Since clindamycin, a key component of Panton-Valentine leucocidin producing methicillin-resistant Staphylococcus aureus treatment, might be removed by Cytosorb® hemo...
Source: The International Journal of Artificial Organs - February 28, 2019 Category: Transplant Surgery Authors: Poli EC, Simoni C, André P, Buclin T, Longchamp D, Perez MH, Ferry T, Schneider AG Tags: Int J Artif Organs Source Type: research

Comparison of intraoperative versus intraoperative plus postoperative hemoadsorption therapy in cardiac surgery patients with endocarditis.
We examined the application of hemoadsorption therapy in 20 endocarditis patients separated into two groups: (1) sole intraoperative versus (2) intraoperative plus postoperative treatment, with regard to inflammatory and hemodynamic status, the postoperative course including development of complications, extent of extracorporeal organ support, and outcome. Despite an obviously more pronounced disease severity in the intraoperative plus postoperatively treated patients as evidenced by a higher initial European System for Cardiac Operative Risk Evaluation score, higher reoperation rate, longer cardiopulmonary bypass times, a...
Source: The International Journal of Artificial Organs - February 25, 2019 Category: Transplant Surgery Authors: Kühne LU, Binczyk R, Rieß FC Tags: Int J Artif Organs Source Type: research

Expansion of mouse hematopoietic stem/progenitor cells in three-dimensional cocultures on growth-suppressed stromal cell layer.
Abstract With the aim of establishing an effective method to expand hematopoietic stem/progenitor cells for application in hematopoietic stem cell transplantation, we performed ex vivo expansion of hematopoietic stem/progenitor cells derived from mouse fetal liver cells in three-dimensional cocultures with stromal cells. In these cocultures, stromal cells were first cultured within three-dimensional scaffolds to form stromal layers and then fetal liver cells containing hematopoietic cells were seeded on these scaffolds to expand the hematopoietic cells over the 2 weeks of coculture in a serum-containing med...
Source: The International Journal of Artificial Organs - February 12, 2019 Category: Transplant Surgery Authors: Miyoshi H, Sato C, Shimizu Y, Morita M Tags: Int J Artif Organs Source Type: research

The positive influence of psychological intervention on the level of anxiety and depression in dialysis patients: A pilot study.
Abstract Medical progress in dialysis therapy made it possible to treat patients with the end-stage renal disease for many years. But at the other side it may lead to profound changes in everyday life and may induce depression and anxiety. The research presented in this article explores the influence of psychological interventions on anxiety and depression levels in patients undergoing dialysis therapy. The experimental design included two experimental groups: cognitive intervention and cognitive/narrative intervention and one control group (standard treatment). In total, 139 participants aged 22-75, including 67 ...
Source: The International Journal of Artificial Organs - January 25, 2019 Category: Transplant Surgery Authors: Bargiel-Matusiewicz K, Łyś A, Stelmachowska P Tags: Int J Artif Organs Source Type: research

Risk factors for adverse outcomes after left ventricular assist device implantation and extracorporeal cardiopulmonary resuscitation.
shuis M Abstract Left ventricular assist device implantation following extracorporeal cardiopulmonary resuscitation has been associated with ambivalent results. In a series of patients who underwent left ventricular assist device implantation after extracorporeal cardiopulmonary resuscitation, we investigated whether the outcome can be predicted by preoperative risk factors or established risk scores. Primary endpoint was a composite of mortality and severe neurological disabling over 1 year of follow-up. To assess predictors of the primary endpoint, we performed univariate and multivariable Cox regression ...
Source: The International Journal of Artificial Organs - January 17, 2019 Category: Transplant Surgery Authors: Ljajikj E, Zittermann A, Koster A, Hata M, Börgermann J, Schönbrodt M, Hakim Meibodi K, Gummert JF, Morshuis M Tags: Int J Artif Organs Source Type: research

Clinical effects of hemoadsorption with CytoSorb ® in patients with severe acute pancreatitis: A case series.
In conclusion, the use of CytoSorb in patients with severe acute pancreatitis was associated with improved hemodynamics and decreased inflammatory markers. PMID: 30638101 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 14, 2019 Category: Transplant Surgery Authors: Tomescu D, Popescu M, David C, Dima S Tags: Int J Artif Organs Source Type: research

A new hydrophilic polysulfone hemodialysis membrane can prevent platelet-neutrophil interactions and successive neutrophil activation.
CONCLUSION:: The ability of polysulfone membranes to activate blood cells is closely related to platelet-neutrophil interaction. Therefore, a biocompatible membrane, like NV-U, can be expected to prevent microaggregate formation during hemodialysis and avoid subsequent cell activation. PMID: 30638104 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 14, 2019 Category: Transplant Surgery Authors: Koga Y, Meguro H, Fujieda H, Ueno Y, Miwa K, Kainoh M Tags: Int J Artif Organs Source Type: research

Antibody-mediated rejection after cardiac transplant: Treatment with immunoadsorption, intravenous immunoglobulin, and anti-thymocyte globulin.
We describe herein a successful treatment for an acute antibody-mediated rejection of cardiac allograft combining immunoadsorption, intravenous immunoglobulins, and anti-thymocyte globulin, which manifested with polymorphic ventricular tachycardia and right ventricular dysfunction. PMID: 30638121 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 14, 2019 Category: Transplant Surgery Authors: Sipahi NF, Saeed D, Makimoto H, Mehdiani A, Akhyari P, Dalyanoglu H, Reinecke P, Lichtenberg A, Boeken U Tags: Int J Artif Organs Source Type: research

A pilot study investigating the effect of pedalling exercise during dialysis on 6-min walking test and hand grip and pinch strength.
Abstract INTRODUCTION:: Haemodialysis patients are at an increased risk of sarcopenia. Physical inactivity is now recognised as a major cause of muscle wasting in haemodialysis patients. It is unclear as to what and how much exercise is required to show benefit. We therefore performed a pilot study of cycling during haemodialysis. METHODS:: Patients underwent a progressive submaximal individualised cycling exercise, 3× a week during haemodialysis for 4 months using bed-cycle ergometers. Body composition was measured by multifrequency segmental bioimpedance and muscle function by 6-min walking tes...
Source: The International Journal of Artificial Organs - January 14, 2019 Category: Transplant Surgery Authors: Desai M, Mohamed A, Davenport A Tags: Int J Artif Organs Source Type: research

Numerical investigation of the influence of a bearing/shaft structure in an axial blood pump on the potential for device thrombosis.
Abstract Adverse events caused by flow-induced thrombus formation around the bearing/shaft of an axial blood pump remain a serious problem for axial blood pumps. Moreover, excessive anticoagulation with thrombosis around the bearing potentially increases the risk of postoperative gastrointestinal bleeding. The purpose of this study is to analyze the influence of the bearing structure on the thrombosis potential of an axial blood pump. The bearing/shaft structure was embedded into an axial blood pump numerical model. The numerical simulation and analysis are focused on the low wall shear stresses, recirculation, an...
Source: The International Journal of Artificial Organs - January 10, 2019 Category: Transplant Surgery Authors: Liu GM, Jin DH, Chen HB, Hou JF, Zhang Y, Sun HS, Zhou JY, Hu SS, Gui XM Tags: Int J Artif Organs Source Type: research

Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis.
Abstract Congenitally corrected transposition of the great arteries and situs inversus totalis are rare congenital anomalies. While congenital heart diseases affect about 0.75%-0.9% of newborns, less than 1% of them have congenitally corrected transposition of the great arteries. Meanwhile, the incidence of situs inversus totalis is about 0.01%. This is a case report of a patient with congenitally corrected transposition of the great arteries and situs inversus totalis who was supported with a ventricular assist device, resulting in a challenging clinical scenario. PMID: 30630389 [PubMed - as supplied by publ...
Source: The International Journal of Artificial Organs - January 10, 2019 Category: Transplant Surgery Authors: Wieloch R, Sipahi NF, Boeken U, Albert A, Akhyari P, Westenfeld R, Lichtenberg A, Saeed D Tags: Int J Artif Organs Source Type: research

Mechanical circulatory support: 60  years of evolving knowledge.
Mechanical circulatory support: 60 years of evolving knowledge. Int J Artif Organs. 2019 Jan 08;:391398818822267 Authors: Terzi A Abstract Since the 1950s when the first devices for mechanical circulatory support were developed, there has been an impressive evolution of their technology. The first pioneering pumps were used to rescue acute complications after cardiac surgery. Advances in technology, increased knowledge of flow dynamics, and a more appropriate selection of the patients who actually need this support have contributed to significantly improve the benefits of this therapy. Today, m...
Source: The International Journal of Artificial Organs - January 8, 2019 Category: Transplant Surgery Authors: Terzi A Tags: Int J Artif Organs Source Type: research

First successful hemoadsorption using CytoSorb ® in a septic pediatric patient in Kazakhstan: A case report.
CONCLUSION:: Treatment using the CytoSorb device was safe and well-tolerated in a pediatric patient and has proven its practical value as an adjuvant therapy for sepsis in pediatric patient populations. PMID: 30614343 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - January 7, 2019 Category: Transplant Surgery Authors: Saparov A, Sazonov V, Tobylbaeva Z, Isakov S, Bekpan A, Autalipov D, Muratbekova B, Manaybekova Z, Anikin V Tags: Int J Artif Organs Source Type: research

Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use.
Abstract Heart failure remains a disease of ever increasing prevalence in the modern world. Patients with end-stage heart failure are being referred increasingly for mechanical circulatory support. Mechanical circulatory support can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. It is also used during cardiopulmonary bypass surgery to maintain circulation while operating on the heart. While mechanical circulatory support can stabilise heart failure and improve quality of life, complications such as infection and thrombosis remain a common risk. Leukocyte...
Source: The International Journal of Artificial Organs - December 26, 2018 Category: Transplant Surgery Authors: Radley G, Ali S, Pieper IL, Thornton CA Tags: Int J Artif Organs Source Type: research

Amnion-derived mesenchymal stem cells improve viability of endothelial cells exposed to shear stress in ePTFE grafts.
CONCLUSION:: hAMSC exerted best survival-enhancing effects on hPEC under exposure to physiological shear stress and modulated endothelial function by paracrine factors. Our data support further studies on the development of grafts functionalized with hAMSC-derived secretomes to enable fast clinical application. PMID: 30585116 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 26, 2018 Category: Transplant Surgery Authors: Pfeiffer D, Wankhammer K, Stefanitsch C, Hingerl K, Huppertz B, Dohr G, Desoye G, Lang I Tags: Int J Artif Organs Source Type: research

It keeps on turning: Effects of prolonged long-term left ventricular assist device support as a bridge to heart transplantation.
Abstract OBJECTIVES:: Increasing incidence of end-stage heart failure has moved the therapy with left ventricular assist devices to the forefront of surgical treatment. Moreover, continuous sophistication in this technology has resulted in increasing proportion of patients on prolonged support. Early and late complications after left ventricular assist device as a bridge to transplantation and present factors associated with long-term support and long-term outcomes of patients supported for at least 1 year were compared. METHODS:: A total of 163 consecutive patients who underwent left ventricular assis...
Source: The International Journal of Artificial Organs - December 24, 2018 Category: Transplant Surgery Authors: Schmack B, Grossekettler L, Zeriouh M, Weymann A, Mohite P, Koch A, Ruhparwar A, Simon AR, Sabashnikov A, Popov AF Tags: Int J Artif Organs Source Type: research

Transient power elevation during iron dextran infusion in a patient with a continuous-flow left ventricular assist device.
In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. We subsequently studied the effects of iron dextran infusion in an in vitro LVAD mock circulatory loop. The observed increase in flow and power was most likely due to drug-patient interaction rather than drug-LVAD interaction. Mock loops and in vivo animal models may be necessary for proactive evaluation of the safety of intravenous (IV) preparations in this patient population. PMID: 30556439 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 16, 2018 Category: Transplant Surgery Authors: Alvarez PA, Byram N, Williams JB, Jacob M, Kreiss M, Fukamachi K, Moazami N Tags: Int J Artif Organs Source Type: research

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.
CONCLUSION:: In these settings, all tested drugs were adsorbed by the cartridge in relevant amounts. The identified maximum adsorptive capacity and the rapid decline in concentration during the first 1.5 h of CytoSorb use suggest that the administration of an additional dose within the first hours of CytoSorb treatment may be reasonable. In addition, early therapeutic drug monitoring should be considered. PMID: 30545255 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 13, 2018 Category: Transplant Surgery Authors: König C, Röhr AC, Frey OR, Brinkmann A, Roberts JA, Wichmann D, Braune S, Kluge S, Nierhaus A Tags: Int J Artif Organs Source Type: research

Patient-specific design process and evaluation of a hip prosthesis femoral stem.
CONCLUSION:: The customized femoral stem presented satisfactory results related to primary stability, but compromising proximo-medial load transfer due to increased stem cross-sectional area increased stem stiffness. PMID: 30537876 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 11, 2018 Category: Transplant Surgery Authors: Abdelaal O, Darwish S, El-Hofy H, Saito Y Tags: Int J Artif Organs Source Type: research

Bloodstream infections during post-cardiotomy extracorporeal membrane oxygenation: Incidence, risk factors, and outcomes.
DISCUSSION:: Infections acquired during veno-arterial extracorporeal membrane oxygenation are common. Identify the risk factors that may improve strategies for treatment and prevention. PMID: 30537880 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - December 11, 2018 Category: Transplant Surgery Authors: Silvetti S, Ranucci M, Pistuddi V, Isgrò G, Ballotta A, Ferraris L, Cotza M Tags: Int J Artif Organs Source Type: research

Development of exercise-related values in heart failure patients supported with a left ventricular assist device.
Abstract Following implantation of a left ventricular assist device, the build-up and long-term maintenance of adequate exercise capacity and functional performance become crucial. The aim of this study was to observe the development of exercise-related values at different times, as well as to detect possible influencing factors. We performed a prospective single-centre study: 10 patients (63 years, 100% male, body mass index = 27.5, 100% HeartWare) underwent the following diagnostic tests during cardiac rehabilitation and during two subsequent ambulatory visits: 6-min walking test, handgrip s...
Source: The International Journal of Artificial Organs - December 6, 2018 Category: Transplant Surgery Authors: Schmidt T, Bjarnason-Wehrens B, Mommertz S, Schulte-Eistrup S, Willemsen D, Sindermann J, Predel HG, Reiss N Tags: Int J Artif Organs Source Type: research

Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer.
Abstract OBJECTIVE:: Extracorporeal circulation devices are coated with a biocompatible polymer coating agent (BPCA) that has a hydrophilic blood-contacting layer, but hemofilters are not. We aimed to investigate the antithrombotic properties of a BPCA-coated hemofilter. METHODS:: Four experiments using BPCA-coated circuits and non-coated hemofilters and four experiments using BPCA-coated circuits and BPCA-coated hemofilters were performed with whole human blood and compared by measuring the circuit pressure every 5 min, antithrombin activity every 40 min, and thrombin-antithrombin complex every...
Source: The International Journal of Artificial Organs - November 29, 2018 Category: Transplant Surgery Authors: Tagaya M, Hara K, Takahashi S, Nagoshi S, Handa H, Okano S, Murataka T Tags: Int J Artif Organs Source Type: research

Development of a simvastatin loaded injectable porous scaffold in situ formed by phase inversion method for bone tissue regeneration.
CONCLUSION:: The results demonstrated that release of simvastatin from the injectable scaffolds can have positive effects on osteogenic differentiation of the adipose-derived stem cells. PMID: 30482084 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 28, 2018 Category: Transplant Surgery Authors: Hajihasani Biouki M, Mobedi H, Karkhaneh A, Daliri Joupari M Tags: Int J Artif Organs Source Type: research

Successful decellularization of thick-walled tissue: Highlighting pitfalls and the need for a multifactorial approach.
CONCLUSION:: In this study, we developed a procedure that grants successful decellularization of porcine aortic wall while maintaining the fibrous microstructure. We highlighted the significant effect of DNase and α-galactosidase treatment. In addition, we could show the need for a multifactorial treatment and comprehensive evaluation protocols for thick tissue decellularization. PMID: 30442045 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 16, 2018 Category: Transplant Surgery Authors: Koenig F, Kilzer M, Hagl C, Thierfelder N Tags: Int J Artif Organs Source Type: research

A new dynamic model for in vitro evaluation of intravascular devices.
DISCUSSION:: A dynamic model for intravascular catheter testing mimics better clinical conditions when evaluating blood-material interaction. Catheter position, blood flow around the catheter, and infusion fluid all have a potential impact on the hemocompatibility of a given catheter. PMID: 30394827 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - November 4, 2018 Category: Transplant Surgery Authors: Baert EJ, Vandersteene J, Dewaele F, Vantilborgh A, Van Roost D, De Somer F Tags: Int J Artif Organs Source Type: research

Impact of setup orientation on blend electrospinning of poly- ε-caprolactone-gelatin scaffolds for vascular tissue engineering.
This article explores the effect of horizontal and vertical setups on blend electrospinning with two polymers having vastly different properties - poly-ε-caprolactone and gelatin, and subsequent effect of the resulting microstructure on viability of seeded cells. METHODS:: Poly-ε-caprolactone and gelatin of varying blend concentrations were electrospun in horizontal and vertical setup orientations. NIH 3T3 fibroblasts were seeded on these scaffolds to assess cell viability changes in accordance with change in microstructure. RESULTS:: Blend electrospinning yielded a heterogeneous microstructure in...
Source: The International Journal of Artificial Organs - November 1, 2018 Category: Transplant Surgery Authors: Suresh S, Gryshkov O, Glasmacher B Tags: Int J Artif Organs Source Type: research

Chondrocytes cultured in silk-based biomaterials maintain function and cell morphology.
CONCLUSION:: Regenerated silk fibroin film was found to be an excellent biomaterial with good cytocompatibility for chondrocytes, because these cells remained functional and maintained normal cell morphology when cultured in silk-based biomaterials. These results suggest that silk-based chondrocyte biomaterial complexes may provide a feasible and functional biomaterial for repairing clinical cartilage defects. PMID: 30376753 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 30, 2018 Category: Transplant Surgery Authors: Ni Y, Jiang Y, Wang K, Shao Z, Chen X, Sun S, Yu H, Li W Tags: Int J Artif Organs Source Type: research

Blood damage in Left Ventricular Assist Devices: Pump thrombosis or system thrombosis?
CONCLUSION:: We extend the perspective of pump thrombosis secondary to the supraphysiologic shear stress environment of the pump to one of Left Ventricular Assist Device system thrombosis, raising the importance of comprehensive characterization of the different prothrombotic risk factors of the total system as the target to achieve enhanced hemocompatibility and improved clinical outcomes. PMID: 30354870 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 24, 2018 Category: Transplant Surgery Authors: Selmi M, Chiu WC, Chivukula VK, Melisurgo G, Beckman JA, Mahr C, Aliseda A, Votta E, Redaelli A, Slepian MJ, Bluestein D, Pappalardo F, Consolo F Tags: Int J Artif Organs Source Type: research

Characterization and biological properties of a novel synthesized silicon-substituted hydroxyapatite derived from eggshell.
Abstract In the present study, the effect of adding different concentrations of silicon on physical, mechanical and biological properties of a synthesized aqueous precipitated eggshell-derived hydroxyapatite (e-HA) was evaluated. No secondary phases were detected by X-ray diffraction for the specimens e-HA and e-HA containing silicon (Si-e-HAs) before and after heating at 1200°C. A reduction in the crystallite size and a-axis as well as an increase in c-axis was occurred when silicon replacement was happened in the structure of e-HA. The presence of Si-O vibrations and carbonate modes for Si-e-HAs was confirme...
Source: The International Journal of Artificial Organs - October 22, 2018 Category: Transplant Surgery Authors: Asadipour K, Nezafati N, Nourbakhsh MS, Hafezi-Ardakani M, Bohlooli S Tags: Int J Artif Organs Source Type: research

Couette shearing device for the investigation of shear-induced damage of the primary hemostasis by left ventricular assist devices.
DISCUSSION:: With the shearing device, half-sine-wave-shaped shear stress patterns relevant to rotary blood pumps can be achieved with very good repeatability. The proposed damage model could be used to compare and optimize left ventricular assist devices under development. The tests showed a significant decrease in coagulability after only a few repetitions. PMID: 30345868 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 22, 2018 Category: Transplant Surgery Authors: Lommel MA, Goubergrits L, Affeld K, Kertzscher U Tags: Int J Artif Organs Source Type: research

Young ESAO challenges in artificial organs.
PMID: 30278804 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 2, 2018 Category: Transplant Surgery Authors: Molteni A, Mueller M Tags: Int J Artif Organs Source Type: research

Evaluation of pre- and post-dilution continuous veno-venous hemofiltration on leukocyte and platelet function in patients with sepsis.
CONCLUSION: Pre-dilution veno-venous hemofiltration demonstrates superior biocompatibility in terms of decreased leukocyte function and platelet activation in septic shock patients with acute kidney injury. PMID: 30278811 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - October 2, 2018 Category: Transplant Surgery Authors: Chihara S, Masuda Y, Tatsumi H, Yamakage M Tags: Int J Artif Organs Source Type: research

Does the plasma refilling coefficient change during hemodialysis sessions?
ski J Abstract The filtration coefficient in the Starling equation is an important determinant of plasma refilling during hemodialysis. A method for calculating from clinical data an estimate of the filtration coefficient, called the refilling coefficient, was proposed in the past. The assumption behind this method was that the only drive for refilling is the increase in plasma oncotic pressure, and the remaining Starling forces have negligible effect. The refilling coefficient was observed to decrease during hemodialysis, and this was interpreted as a change in the filtration coefficient. The purpose of our study...
Source: The International Journal of Artificial Organs - October 2, 2018 Category: Transplant Surgery Authors: Pietribiasi M, Wójcik-Załuska A, Załuska W, Waniewski J Tags: Int J Artif Organs Source Type: research

Salvage extracorporeal membrane oxygenation in induction-associated acute respiratory distress syndrome in acute leukemia patients: A case series.
CONCLUSION: Currently, the use of extracorporeal membrane oxygenation in patients with hematologic malignancies who develop severe acute respiratory distress syndrome remains controversial. Although extracorporeal membrane oxygenation in post-allogeneic hematopoietic stem cell transplant is associated with poorer outcomes, our data suggest that salvage extracorporeal membrane oxygenation support is a viable option to manage moderate to severe acute respiratory distress syndrome while completing therapeutic chemotherapy and following in the peri-induction phase of acute leukemia. PMID: 30223700 [PubMed - as supplied by...
Source: The International Journal of Artificial Organs - September 17, 2018 Category: Transplant Surgery Authors: Huprikar NA, Peterson MR, DellaVolpe JD, Sams VG, Lantry JH, Walter RJ, Osswald MB, Chung KK, Mason PE Tags: Int J Artif Organs Source Type: research

Optimal drainage cannula position in dual cannulation for veno-venous extracorporeal membrane oxygenation.
CONCLUSION: With respect to blood oxygenation, the optimal position for the drainage cannula was the upper inferior vena cava. These findings suggested that blood from the superior vena cava, inferior vena cava, and hepatic vein was most efficiently drained in the upper inferior vena cava cannula position. PMID: 30223702 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - September 17, 2018 Category: Transplant Surgery Authors: Togo K, Takewa Y, Katagiri N, Fujii Y, Yamashita AC, Tastumi E Tags: Int J Artif Organs Source Type: research

Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities.
Abstract OBJECTIVE: To investigate associations of sex-age-specific handgrip strength by a dynamometer with all-cause mortality and the percent excess risk explained (%ERE) by comorbidities and nutritional indicators in incident maintenance hemodialysis patients. METHODS: Prospective cohort of 413 adult patients (165 women, 248 men, 299
Source: The International Journal of Artificial Organs - September 11, 2018 Category: Transplant Surgery Authors: Lopes MB, Silva LF, Dantas MA, Matos CM, Lopes GB, Lopes AA Tags: Int J Artif Organs Source Type: research

Tubular vesicopyelostomy for the management of types 2 and 3 (long-segment) ureteric stenosis after kidney transplantation.
In this study, we present the long-term results of tubular bladder reconfiguration and cystopyelostomy (tubular vesicopyelostomy), an innovative and practical procedure for the management of long-segment ureteric stenosis (types 2 and 3) after transplantation. Between 2002 and 2017, 722 kidney transplant patients were monitored at the University of Medical Sciences, Bozyaka Organ Transplantation and Research Center. Twenty-eight of these patients underwent tubular vesicopyelostomy operation; 17 male and 11 female patients with a mean age of 45.6 ± 10.5 years. Time to surgical intervention for ur...
Source: The International Journal of Artificial Organs - September 5, 2018 Category: Transplant Surgery Authors: Uslu A, Cayhan VK, Simsek C, Aykas A, Karatas M, Tarcan IC, Okut G, Tatar E Tags: Int J Artif Organs Source Type: research

Normal fluid stresses are prevalent in rotary ventricular assist devices: A computational fluid dynamics analysis.
This study is the first to quantify the fluid stress components in real blood contacting devices. PMID: 30141359 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 24, 2018 Category: Transplant Surgery Authors: Khoo DP, Cookson AN, Gill HS, Fraser KH Tags: Int J Artif Organs Source Type: research

The use of a virtual patient to follow changes in arterial blood gases associated with therapeutic thoracentesis.
CONCLUSION: Therapeutic thoracentesis may cause both an increase and a decrease in PaO2 during the procedure. Pleural pressure decrease, caused by pleural fluid withdrawal, improves the perfusion of atelectatic lung areas. If the rate of recruitment of these areas is low, a lack of ventilation causes the arterial blood oxygen tension to fall. Effective hypoxic pulmonary vasoconstriction may protect against the pulmonary shunt. PMID: 30141367 [PubMed - as supplied by publisher] (Source: The International Journal of Artificial Organs)
Source: The International Journal of Artificial Organs - August 24, 2018 Category: Transplant Surgery Authors: Stecka AM, Gólczewski T, Grabczak EM, Zieliński K, Michnikowski M, Zielińska-Krawczyk M, Korczyński P, Krenke R Tags: Int J Artif Organs Source Type: research