Interleukin-6: A neuro-active cytokine contributing to cognitive impairment in Duchenne muscular dystrophy?
Abstract Interleukin-6 (IL-6) is a pro-inflammatory cytokine, classically associated with orchestrating an immune response to invading pathogens. However, IL-6 can also directly or indirectly modify central nervous system function, and thereby alter higher-order functions, such as learning and the consolidation of memories. IL-6 is chronically elevated in Duchenne Muscular Dystrophy (DMD), a neuromuscular disorder arising when a mutation causes the loss of the structural protein, dystrophin. Absence of dystrophin leads to progressive immobility, chronic inflammation and premature death. However, the role of dystro...
Source: Cytokine - May 23, 2020 Category: Molecular Biology Authors: Stephenson KA, Rae MG, O'Malley D Tags: Cytokine Source Type: research

The utility of serum C-C chemokine ligand 1 in sarcoidosis: A comparison to IgG4-related disease.
In this study, we sought to decipher the correlation between serum levels of CCL1 and clinical characteristics of sarcoidosis. Serum samples were obtained from 44 patients with clinically confirmed sarcoidosis, 14 patients with IgG4-RD, and 14 healthy controls. The clinical and radiological findings were retrospectively evaluated. Serum levels of CCL1 were measured using a sandwich enzyme-linked immunosorbent assay. Serum levels of other 17 cytokines and chemokines were measured using a MILLIPLEX® MAP KIT and Luminex® magnetic beads. Serum levels of CCL1 were significantly higher in patients with sarcoidosis than i...
Source: Cytokine - May 21, 2020 Category: Molecular Biology Authors: Komatsu M, Yamamoto H, Yasuo M, Ushiki A, Nakajima T, Uehara T, Kawakami S, Hanaoka M Tags: Cytokine Source Type: research

Pyrrolidine dithiocarbamate and dexamethasone are novel treatments of Acute Exogenous Lipoid Pneumonia.
CONCLUSIONS: Individual or combined use of PDTC and DXM can ameliorate pulmonary inflammation induced by inhalation of sewing machine oil by inhibiting the NF-κB pathway in young rats. These findings provide novel insights that will greatly contribute in treatment of AELP. PMID: 32446224 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 20, 2020 Category: Molecular Biology Authors: Liang DS, Huang AR, Lin MM, Xia XJ, Jin YM Tags: Cytokine Source Type: research

Gastric banding-associated weight loss diminishes hepatic Tsukushi expression.
In conclusion, LAGB-induced weight loss reduces hepatic TSK expression. Inhibiting TSK might represent a promising target for treating NAFLD in the future. PMID: 32442908 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 19, 2020 Category: Molecular Biology Authors: Grander C, Jaschke N, Enrich B, Grabherr F, Mayr L, Schwärzler J, Effenberger M, Adolph TE, Tilg H Tags: Cytokine Source Type: research

Activin and inhibin signaling: From regulation of physiology to involvement in the pathology of the female reproductive system.
Abstract Activins and inhibins - comprising activin A, B, AB, C and E, and inhibin A and B isoforms - belong to the transforming growth factor beta (TGFβ) superfamily. They regulate several biological processes, including cellular proliferation, differentiation and invasiveness, to enhance the formation and functioning of many human tissues and organs. In this review, we have discussed the role of activin and inhibin signaling in the physiological and female-specific pathological events that occur in the female reproductive system. The up-to-date evidence indicates that these cytokines regulate germ cell deve...
Source: Cytokine - May 18, 2020 Category: Molecular Biology Authors: Appiah Adu-Gyamfi E, Tanam Djankpa F, Nelson W, Czika A, Kumar Sah S, Lamptey J, Ding YB, Wang YX Tags: Cytokine Source Type: research

Vascular endothelial growth factor and transforming growth factor β in hypertrophic adenoids in children suffering from otitis media with effusion.
Vascular endothelial growth factor and transforming growth factor β in hypertrophic adenoids in children suffering from otitis media with effusion. Cytokine. 2020 May 18;133:155125 Authors: Zelazowska-Rutkowska B, Skotnicka B, Cylwik B Abstract OBJECTIVES: The study objective was to assess the levels of VEGF-A and TGF-β cytokines in the children with adenoid hypertrophy concomitant with exudative otitis media (OME) and in children with adenoid hypertrophy (HA) alone. METHODS: The study material consisted of hypertrophic adenoids removed during adenoidectomy from 39 children (20 girls an...
Source: Cytokine - May 18, 2020 Category: Molecular Biology Authors: Zelazowska-Rutkowska B, Skotnicka B, Cylwik B Tags: Cytokine Source Type: research

Peptidomic analysis on synovial tissue reveals galectin-1 derived peptide as a potential bioactive molecule against rheumatoid arthritis.
Abstract BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease that leads to small joints irreversible destruction. Despite intense efforts, the pathophysiology of RA currently remains unclear. We aimed to gain insight into the pathophysiology process in peptidomic perspective and to identify bioactive peptides for RA treatment. METHODS: The endogenous peptides in synovial tissue between control and rheumatoid arthritis group were identified by liquid chromatography-mass spectrometry (LC-MS/MS). Since the biological function of peptides were always associated with precursor proteins, the potential fu...
Source: Cytokine - May 12, 2020 Category: Molecular Biology Authors: Hu J, Lu J, Zhang X, Wang C, Ren K, Chang Q, Ji M, Pan W, Ma B, Fan W Tags: Cytokine Source Type: research

Comment on: Increased IL-35 producing Tregs and CD19+IL-35+ cells are associated with disease progression in leprosy patients.
PMID: 32402527 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 10, 2020 Category: Molecular Biology Authors: Chen Y, Liu J Tags: Cytokine Source Type: research

Corrigendum to "Adenosine augments the production of IL-10 in cervical cancer cells through interaction with the A2B adenosine receptor, resulting in protection against the activity of cytotoxic T cells" [Cytokine 130 (2020) 155082].
Corrigendum to "Adenosine augments the production of IL-10 in cervical cancer cells through interaction with the A2B adenosine receptor, resulting in protection against the activity of cytotoxic T cells" [Cytokine 130 (2020) 155082]. Cytokine. 2020 May 08;:155110 Authors: Torres-Pineda DB, de Lourdes Mora-García M, García-Rocha R, Hernández-Montes J, Weiss-Steider B, Montesinos-Montesinos JJ, Don-López CA, Marín-Aquino LA, Muñóz-Godínez R, Ibarra LRÁ, Romero RL, Monroy-García A PMID: 32402526 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 8, 2020 Category: Molecular Biology Authors: Torres-Pineda DB, de Lourdes Mora-García M, García-Rocha R, Hernández-Montes J, Weiss-Steider B, Montesinos-Montesinos JJ, Don-López CA, Marín-Aquino LA, Muñóz-Godínez R, Ibarra LRÁ, Romero RL, Monroy-García A Tags: Cytokine Source Type: research

Analysis of interleukins 6, 8, 10 and 17 in the lungs of premature neonates with bronchopulmonary dysplasia.
This study showed that the involvement of interleukins 6, 8, and 10 might not be significantly different between the two types of BPD. We speculated that IL-17A could be a protective factor in this disease. PMID: 32403004 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 8, 2020 Category: Molecular Biology Authors: Witkowski SM, de Castro EM, Nagashima S, Martins APC, Okamoto CT, Nakata GTM, Collete M, Machado-Souza C, de Noronha L Tags: Cytokine Source Type: research

Upregulation of circulating inflammatory biomarkers under the influence of periodontal disease in rheumatoid arthritis patients.
CONCLUSION: Periodontal disease augments systemic inflammation in RA. A profound influence exists independent of autoimmune status. PMID: 32403006 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 8, 2020 Category: Molecular Biology Authors: Panezai J, Ali A, Ghaffar A, Benchimol D, Altamash M, Klinge B, Engström PE, Larsson A Tags: Cytokine Source Type: research

Longifolioside A inhibits TLR4-mediated inflammatory responses by blocking PKC δ activation in LPS-stimulated THP-1 macrophages.
Longifolioside A inhibits TLR4-mediated inflammatory responses by blocking PKCδ activation in LPS-stimulated THP-1 macrophages. Cytokine. 2020 May 07;131:155116 Authors: Lee SU, Oh ES, Ryu HW, Kim MO, Kang MJ, Song YN, Lee RW, Kim DY, Ro H, Jung S, Hong ST, Oh SR Abstract Longifolioside A is an iridoid glucoside compound isolated from Pseudolysimachion rotundum var. subintegrum, which has been used in traditional herbal medicines to treat respiratory inflammatory diseases. Logifolioside A is a potent antioxidant; however, its underlying pharmacological mechanisms of action in inflammatory diseas...
Source: Cytokine - May 7, 2020 Category: Molecular Biology Authors: Lee SU, Oh ES, Ryu HW, Kim MO, Kang MJ, Song YN, Lee RW, Kim DY, Ro H, Jung S, Hong ST, Oh SR Tags: Cytokine Source Type: research

A C-terminal fragment of adhesion protein Fibulin7 regulates neutrophil migration and functions and improves survival in LPS induced systemic inflammation.
In conclusion, our results show that Fbln7-C could bind to the integrin β1 on the neutrophil surface and regulate their inflammatory functions. PMID: 32388247 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 6, 2020 Category: Molecular Biology Authors: Chakraborty P, Dalpati N, Bhan C, Dash SP, Kumar P, Sarangi PP Tags: Cytokine Source Type: research

Corrigendum to "Bulk and single cell transcriptomic data indicate that a dichotomy between inflammatory pathways in peripheral blood and arthritic joints complicates biomarker discovery" [Cytokine 127 (2020) 154960].
Corrigendum to "Bulk and single cell transcriptomic data indicate that a dichotomy between inflammatory pathways in peripheral blood and arthritic joints complicates biomarker discovery" [Cytokine 127 (2020) 154960]. Cytokine. 2020 May 04;:155087 Authors: Lee EJ, Lilja S, Li X, Schäfer S, Zhang H, Benson M PMID: 32381371 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 4, 2020 Category: Molecular Biology Authors: Lee EJ, Lilja S, Li X, Schäfer S, Zhang H, Benson M Tags: Cytokine Source Type: research

The effects of acetyl-11-keto- β-boswellic acid on brain cytokines and memory impairment induced by lipopolysaccharide in rats.
The effects of acetyl-11-keto-β-boswellic acid on brain cytokines and memory impairment induced by lipopolysaccharide in rats. Cytokine. 2020 May 04;131:155107 Authors: Marefati N, Beheshti F, Memarpour S, Bayat R, Naser Shafei M, Sadeghnia HR, Ghazavi H, Hosseini M Abstract The therapeutic effects of the olibanum, the resin of Boswellia serrata on inflammatory diseases have been reported. There are more than 200 active ingredients in this resin including acetyl-11-keto-β-boswellic acid (AKBA). We proposed that AKBA can improve memory impairment induced by cerebral inflammation following the...
Source: Cytokine - May 4, 2020 Category: Molecular Biology Authors: Marefati N, Beheshti F, Memarpour S, Bayat R, Naser Shafei M, Sadeghnia HR, Ghazavi H, Hosseini M Tags: Cytokine Source Type: research

Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy.
This study aims to investigate the effects of non-intensive interdisciplinary therapy on cardiometabolic parameters including leptin, adiponectin and adiponectin/leptin ratio as a dependent manner on its magnitude of weight loss reduction. METHODS AND RESULTS: Thirty-eight adolescents (14-19 y.o) were enrolled in an interdisciplinary therapy for 20 weeks. Body composition, biochemical parameters, leptin and adiponectin were measured at baseline and after therapy. The adolescents were divided into two groups according to the magnitude of total weight loss, less than 5% (
Source: Cytokine - May 1, 2020 Category: Molecular Biology Authors: Alaby Martins Ferreira Y, Claudia Pelissari Kravchychyn A, de Castro Ferreira Vicente S, Munhoz da Silveira Campos R, Tock L, Missae Oyama L, Tadeu Boldarine V, Cristina Landi Masquio D, Dâmaso AR Tags: Cytokine Source Type: research

The LncRNA H19/miR-1-3p/CCL2 axis modulates lipopolysaccharide (LPS) stimulation-induced normal human astrocyte proliferation and activation.
In conclusion, lncRNA H19, miR-1-3p, and CCL2 form a lncRNA-miRNA-mRNA axis that modulates NHA proliferation and activation in vitro. PMID: 32371379 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - May 1, 2020 Category: Molecular Biology Authors: Li P, Li Y, Dai Y, Wang B, Li L, Jiang B, Wu P, Xu J Tags: Cytokine Source Type: research

Retraction notice to "Aberrant frequency of IL-35 producing B cells in colorectal cancer patients" [Cytokine 102 (2018) 206-210].
Retraction notice to "Aberrant frequency of IL-35 producing B cells in colorectal cancer patients" [Cytokine 102 (2018) 206-210]. Cytokine. 2020 May;129:154982 Authors: Wang K, Gong H, Chai R, Yuan H, Chen Y, Liu J PMID: 32200949 [PubMed - in process] (Source: Cytokine)
Source: Cytokine - March 25, 2020 Category: Molecular Biology Authors: Wang K, Gong H, Chai R, Yuan H, Chen Y, Liu J Tags: Cytokine Source Type: research

Macrophages represent the major pool of IL-7R α expressing cells in patients with myocarditis.
Macrophages represent the major pool of IL-7Rα expressing cells in patients with myocarditis. Cytokine. 2020 Mar 20;130:155053 Authors: Kubin N, Richter M, Sen-Hild B, Akintürk H, Schönburg M, Kubin T, Cetinkaya A Abstract Myocarditis is characterized by infiltration and activation of cytokine as well as chemokine receptors frequently producing heart failure. Causes are often infections triggering inflammatory and immune responses but these initial lines of defense might be finally disastrous. To identify mediators we screened various receptors by confocal microscopy and identified car...
Source: Cytokine - March 20, 2020 Category: Molecular Biology Authors: Kubin N, Richter M, Sen-Hild B, Akintürk H, Schönburg M, Kubin T, Cetinkaya A Tags: Cytokine Source Type: research

Pinitol suppresses TNF- α-induced chondrocyte senescence.
Pinitol suppresses TNF-α-induced chondrocyte senescence. Cytokine. 2020 Mar 19;130:155047 Authors: Lou C, Deng A, Zheng H, Sun G, Zhao H, Li A, Liu Q, Li Y, Lv Z Abstract Osteoarthritis (OA) is a highly prevalent joint disorder that is tightly correlated with age. As the body ages, cell replication and function decline until homeostasis can no longer be maintained. This process involves cellular senescence as well as replicative senescence. Telomere length, cell cycle arrest, expression of p16 and p53, and the release of senescence-associated β-galactosidase (SA-β-Gal) are all markers ...
Source: Cytokine - March 19, 2020 Category: Molecular Biology Authors: Lou C, Deng A, Zheng H, Sun G, Zhao H, Li A, Liu Q, Li Y, Lv Z Tags: Cytokine Source Type: research

STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation.
Abstract Deregulated activation of the latent transcription factor STAT3 has been implicated in the pathogenesis of myeloproliferative and lymphoproliferative hematologic disorders. The uncontrolled activation of STAT3 has traditionally been assigned to its elevated phosphorylation at tyrosine 705 (pY705) and associated nuclear transcriptional activity. By contrast, a transcriptional role for serine 727 phosphorylation (pS727) of STAT3 has recently emerged, suggesting that pS727 may account for the pathological activity of STAT3 in certain disease settings. Here, by coupling pS727-STAT3-deficient Stat3SA/SA mice w...
Source: Cytokine - March 19, 2020 Category: Molecular Biology Authors: Balic JJ, White CL, Dawson R, Gough D, McCormack MP, Jenkins BJ Tags: Cytokine Source Type: research

Cerebrospinal fluid cytokines and chemokines in children with Lyme neuroborreliosis; pattern and diagnostic utility.
CONCLUSIONS: The intrathecal immune reaction in LNB is characterized by B cell associated chemokines. Whether the combination CXCL13/CCL19 further improves discrimination between LNB and NLAM beyond the diagnostic improvements by CXCL13 alone needs to be tested in new studies. PMID: 32199247 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - March 18, 2020 Category: Molecular Biology Authors: Barstad B, Henningsson AJ, Tveitnes D, Ushakova A, Noraas S, Ask IS, Bosse FJ, Øymar K Tags: Cytokine Source Type: research

Profiling inflammatory response in lesions of cutaneous leishmaniasis patients using a non-invasive sampling method combined with a high-throughput protein detection assay.
CONCLUSION: We herein report a novel approach based on a non-invasive sampling method combined with the high-throughput protein assay for profiling inflammatory proteins in CL lesions. Using this approach, we could profile inflammatory proteins in the lesions from CL patients. This new non-invasive approach may have implications for studying skin inflammatory mediators in CL and other skin disorders. PMID: 32199248 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - March 17, 2020 Category: Molecular Biology Authors: Taslimi Y, Agbajogu C, Brynjolfsson SF, Masoudzadeh N, Mashayekhi V, Gharibzadeh S, Östensson M, Nakka SS, Mizbani A, Rafati S, Harandi AM Tags: Cytokine Source Type: research

Immunohistochemical localization of TNF- α and IL-4 in granulomas of immunocompetent and immunosuppressed New Zealand white rabbits infected with Encephalitozoon cuniculi.
The objective of the current study was to detect the distribution of TNF-α- and IL-4-positive cells using immunohistochemistry within these granulomas in both infected immunocompetent (group A) and immunosuppressed (group B) New Zealand white rabbits. In the brain, labeled TNF-α immune cells were mainly located in the granuloma peripheries in group B. Granulomas examined in the kidneys of groups A and B were TNF-α positive, but were significantly different (p  0.05), was observed. IL-4 positive cells were more numerous in brain sections of group B and differed significantly (p 
Source: Cytokine - March 14, 2020 Category: Molecular Biology Authors: Dávila-Martínez C, Castillo-Velázquez U, Soto-Domínguez A, Nevárez-Garza AM, Arce-Mendoza AY, Hernandez-Vidal G, Zamora-Avila DE, Rodriguez-Tovar LE Tags: Cytokine Source Type: research

Stability of 40 cytokines/chemokines in chronically ill patients under different storage conditions.
This study identified several clinically important cytokines that are remarkably stable in blood and plasma, and some that stored poorly. To our knowledge, this is the first cytokine storage study to use medically unwell patient samples and equivalence testing to evaluate the stability of measured cytokine values after storage. PMID: 32182456 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - March 14, 2020 Category: Molecular Biology Authors: Binnington B, Sakac D, Yi Q, Tong TN, Parmar N, Duong TT, Yeung RSM, Pendergrast J, Branch DR Tags: Cytokine Source Type: research

Combination of genetic polymorphisms in TLR influence cytokine profile in HCV patients treated with DAAs in the State of Amazonas.
ia F, Malheiro A Abstract Hepatitis C is a public health problem and affects approximately 3% of the world's population. HCV infections have a wide spectrum of clinical manifestations, and several single nucleotide polymorphisms (SNPs) in the genes of the toll-like receptors are cited to influence the clinical outcomes. A cross-sectional study was conducted in the Amazonas State, Brazil in which SNPs in TLR4 and TLR9 genes were genotyped by PCR-RFLP in 151 HCV chronic liver disease patients and 206 healthy donors. The circulating cytokines IL-6, TNF, IL-10, IL-2, IFN-γ, IL-4 and IL-17A were measured by cytom...
Source: Cytokine - March 13, 2020 Category: Molecular Biology Authors: Tarragô AM, da Silva Neto PV, Ramasawmy R, Pereira GL, Toro DM, de Amorim Xabregas L, Costa AG, Victória MB, da Silva Victória F, Malheiro A Tags: Cytokine Source Type: research

Associations of polymorphisms in interleukins with susceptibility to breast cancer: Evidence from a meta-analysis.
CONCLUSIONS: Collectively, this meta-analysis demonstrated that IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800896, IL-18 rs1946518 and rs187238 polymorphisms may confer susceptibility to BC for East Asians from China. PMID: 32163880 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - March 9, 2020 Category: Molecular Biology Authors: Xu G, Wang F Tags: Cytokine Source Type: research

Discriminative expression of CD39 and CD73 in Cerebrospinal fluid of patients with Multiple Sclerosis and Neuro-Beh çet's disease.
Discriminative expression of CD39 and CD73 in Cerebrospinal fluid of patients with Multiple Sclerosis and Neuro-Behçet's disease. Cytokine. 2020 Mar 06;130:155054 Authors: Bahrini K, Belghith M, Maghrebi O, Bekir J, Kchaou M, Jeridi C, Amouri R, Hentati F, Belal S, Ben Sassi S, Barbouche MR Abstract Treg-mediated immune suppression involves many molecular mechanisms including the cleavage of inflammatory extracellular ATP to adenosine by CD39 ectoenzyme. In the peripheral blood of Multiple Sclerosis (MS) patients, it has been suggested that CD39+ Treg cells have the potential to suppress pro-in...
Source: Cytokine - March 6, 2020 Category: Molecular Biology Authors: Bahrini K, Belghith M, Maghrebi O, Bekir J, Kchaou M, Jeridi C, Amouri R, Hentati F, Belal S, Ben Sassi S, Barbouche MR Tags: Cytokine Source Type: research

Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study.
This study aimed to reveal a new dimension of allergy profiles in the general population by using machine learning to explore complex relationships among various cytokines/chemokines and allergic diseases (asthma and atopic dermatitis; AD). We examined the symptoms related to asthma and AD and the plasma levels of 72 cytokines/chemokines obtained from a general population of 161 children at 6 years of age who participated in a pilot birth cohort study of the Japan Environment and Children's Study (JECS). The children whose signs and symptoms fulfilled the criteria of AD, which are mostly based on questionnaire includi...
Source: Cytokine - March 6, 2020 Category: Molecular Biology Authors: Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y Tags: Cytokine Source Type: research

Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function.
Abstract Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasmic reticulum (ER) has been implicated as a potentially crucial site in regulating CD4+ T cell function. Secretory and transmembrane proteins are shuttled into the ER via the Sec61 translocon, where they undergo appropriate folding; misfolded proteins are retro-translocated from the ER i...
Source: Cytokine - March 5, 2020 Category: Molecular Biology Authors: Pradeep Yeola A, Akbar I, Baillargeon J, Mercy Ignatius Arokia Doss P, Paavilainen VO, Rangachari M Tags: Cytokine Source Type: research

Pre-treatment serum IL-10 predicts the risk of secondary central nervous system involvement in patients with diffuse large B-cell lymphoma.
Abstract BACKGROUND: As diffuse large B-cell lymphoma (DLBCL) is a very heterogeneous group of lymphomas, much effort has gone in trying to identify patients with increased risk for early death or secondary central nervous system (CNS) involvement. To better predict their outcomes, we measured the levels of various cytokines in serum samples of patients with DLBCL and analyzed their clinical outcomes. METHODS: We measured the levels of seven serum cytokines at diagnosis in 313 DLBCL patients who were treated with R-CHOP. Their impact on clinical outcomes, including time to secondary CNS involvement and the 3-...
Source: Cytokine - March 2, 2020 Category: Molecular Biology Authors: Yi JH, Yoon SE, Ryu KJ, Ko YH, Kim WS, Kim SJ Tags: Cytokine Source Type: research

Pretreatment of nafithromycin attenuates inflammatory response in murine lipopolysaccharide induced acute lung injury.
Abstract Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI wherein the bacterial cell components play a crucial role. Macrolide/ketolide antibiotics are reported to possess immunomodulatory activity; as a result improved survival has been noted in pneumonia patients. Hence immunomodulatory activity of nafithromycin, a novel lactone ketolide antibacter...
Source: Cytokine - February 29, 2020 Category: Molecular Biology Authors: Trivedi J, Shaikh J, Chavan N, Thorve D, Chaudhary B, Karade A, Gupta S, Patel A, Bhagwat S Tags: Cytokine Source Type: research

PI3K mediates tumor necrosis factor induced-necroptosis through initiating RIP1-RIP3-MLKL signaling pathway activation.
In this study, we found that TNF-induced necroptosis was inhibited by chemical inhibition or genetic deletion of PI3K. Moreover, knockdown of p110α, the catalytic subunit of PI3K, significantly suppressed the phosphorylation of PI3K substrate protein AKT, and TNF-induced necroptosis was blocked by AKT inhibitors. Furthermore, we found that p110α knockdown also suppressed the phosphorylation and oligomerization of RIP1, RIP3 and MLKL in response to TNF stimulation. In addition to the critical role in mediating TNF-induced necrosome formation, p110α was also essential for the spontaneous phosphorylation of ...
Source: Cytokine - February 27, 2020 Category: Molecular Biology Authors: Hu S, Chang X, Zhu H, Wang D, Chen G Tags: Cytokine Source Type: research

The effect of vitamin d-calcium co-supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.
Abstract Data on the effect of vitamin d-calcium co-supplementation on inflammatory biomarkers, compared to placebo or intake of calcium and vitamin D supplements alone, are conflicting. The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize available findings on the effect of vitamin d-calcium co-supplementation on inflammatory biomarkers in adults. Online databases including PubMed, Scopus, ISI Web of Science and Google Scholar were searched using relevant keywords up to June 2019. We included RCTs investigating the effect of vitamin d-calcium co-supplem...
Source: Cytokine - February 26, 2020 Category: Molecular Biology Authors: Asbaghi O, Sadeghian M, Mozaffari-Khosravi H, Maleki V, Shokri A, Hajizadeh-Sharafabad F, Alizadeh M, Sadeghi O Tags: Cytokine Source Type: research

Macrophage profile and homing into breast milk in response to ongoing respiratory infections in the nursing infant.
This study investigated CD16+ and CD16- macrophage homing into breast milk in response to ongoing infections in nursing infants. Peripheral blood and mature milk were collected from 33 healthy mothers of nursing infants with respiratory infections (Group I) and from 26 healthy mothers of healthy nursing infants (Group H). Blood and milk total, CD16- and CD16+ monocyte (Mo)/macrophage (Mφ) subsets, respectively, and CCR2 and CX3CR1 expression and cytokine levels were analyzed by flow cytometry. CCL2 and CX3CL1 were quantified by ELISA and cytokines by flow cytometry in serum and milk. There was an increase of total and ...
Source: Cytokine - February 25, 2020 Category: Molecular Biology Authors: Zheng Y, Corrêa-Silva S, de Souza EC, Maria Rodrigues R, da Fonseca FAM, Gilio AE, Carneiro-Sampaio M, Palmeira P Tags: Cytokine Source Type: research

Stability of 12 T-helper cell-associated cytokines in human serum under different pre-analytical conditions.
Abstract Cytokines are soluble and readily analyzed signaling molecules which reveal vital cues about the state of the immune system. As such, they serve in diagnosis and monitoring of immune-related disorders, where strictly controlled handling of the samples including storage and freeze/thawing procedures are required. In basic research and clinical trials, human serum samples can be left for long-term storage before processing. Storage space is commonly limited in scientific laboratories, which require storage of fewer but larger aliquots of patient serum samples. There are also practical limitations to the num...
Source: Cytokine - February 25, 2020 Category: Molecular Biology Authors: Stervbo U, Bajda S, Wehler P, Rohn BJ, Streichhahn M, Temizsoy S, Kohut E, Roch T, Viebahn R, Westhoff TH, Babel N Tags: Cytokine Source Type: research

Retraction notice to "Alterations in cytokine gene expression profile in colon mucosa of inflammatory bowel disease patients on different therapeutic regimens" [Cytokine 92 (2017) 12-19].
Retraction notice to "Alterations in cytokine gene expression profile in colon mucosa of inflammatory bowel disease patients on different therapeutic regimens" [Cytokine 92 (2017) 12-19]. Cytokine. 2020 Feb 20;:155018 Authors: Velikova T, Kyurkchiev D, Spassova Z, Karakolev I, Ivanova-Todorova E, Altankova I, Stanilova S PMID: 32089404 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - February 20, 2020 Category: Molecular Biology Authors: Velikova T, Kyurkchiev D, Spassova Z, Karakolev I, Ivanova-Todorova E, Altankova I, Stanilova S Tags: Cytokine Source Type: research

Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy.
inen A, Purhonen AK Abstract In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN ...
Source: Cytokine - February 19, 2020 Category: Molecular Biology Authors: Korpelainen S, Hämäläinen S, Vänskä M, Koivula I, Pulkki K, Jantunen E, Juutilainen A, Purhonen AK Tags: Cytokine Source Type: research

An update on the association between metabolic syndrome and osteoarthritis and on the potential role of leptin in osteoarthritis.
This study aimed to provide an update on the association between MetS and OA and on the potential role of leptin in OA. In this review, we summarized the current knowledge of the association between MetS and OA and updated the evidence on the potential role of leptin in OA. Clinical studies have investigated the epidemiologic association between MetS or its components and OA. Results suggested strong epidemiologic associations between MetS and OA, especially in the Asian population. Animal studies also indicated that metabolic dysregulation may lead to OA pathogenesis. The systemic role of MetS in OA pathophysiology is ass...
Source: Cytokine - February 17, 2020 Category: Molecular Biology Authors: Gao YH, Zhao CW, Liu B, Dong N, Ding L, Li YR, Liu JG, Feng W, Qi X, Jin XH Tags: Cytokine Source Type: research

Leishmania infantum amastin protein incorporated in distinct adjuvant systems induces protection against visceral leishmaniasis.
In conclusion, the present study shows the first case of an L. infantum amastin protein associated with distinct delivery systems inducing protection against L. infantum infection and demonstrates an immunogenic effect of this protein in human cells. PMID: 32062145 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - February 12, 2020 Category: Molecular Biology Authors: Ribeiro PAF, Vale DL, Dias DS, Lage DP, Mendonça DVC, Ramos FF, Carvalho LM, Carvalho AMRS, Steiner BT, Roque MC, Oliveira-da-Silva JA, Oliveira JS, Tavares GSV, Galvani NC, Martins VT, Chávez-Fumagalli MA, Roatt BM, Moreira RLF, Menezes-Souza D, Olivei Tags: Cytokine Source Type: research

The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis.
CONCLUSIONS: Plasma Angpt-2 was related to cytokines, but Angpt-2/1 ratio was a good predictor of 28-day mortality in patients with sepsis. PMID: 32059166 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - February 11, 2020 Category: Molecular Biology Authors: Seol CH, Yong SH, Shin JH, Lee SH, Leem AY, Park SM, Kim YS, Chung KS Tags: Cytokine Source Type: research

ROR- α-1 inhibits the proliferation, invasion, and migration of hepatocellular carcinoma MHCC97H via downregulation of chemokine CXCL5.
In conclusion, we demonstrate the tumor-suppressive role of ROR-α-1 in MHCC97H cells and that ROR-α-1 might play a tumor-suppressive role via regulation of chemokine CXCL5. PMID: 32058275 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - February 10, 2020 Category: Molecular Biology Authors: Liu G, Yang ZF, Zhou PY, Zhou C, Guan RY, Sun BY, Fan J, Zhou J, Yi Y, Qiu SJ Tags: Cytokine Source Type: research

Pathogenic and protective roles of cytokines in pemphigus: A systematic review.
In conclusion, cytokines are deeply involved in PV and PF pathogenesis, and targeting specific cytokines may lead to development of more promising treatments for pemphigus. PMID: 32058276 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - February 10, 2020 Category: Molecular Biology Authors: Tavakolpour S, Mahmoudi H, Mirzazadeh A, Balighi K, Darabi-Monadi S, Hatami S, GhasemiAdl M, Daneshpazhooh M Tags: Cytokine Source Type: research

An inflammatory stimulus sensitizes TRPA1 channel to increase cytokine release in human lung fibroblasts.
This study utilized human lung fibroblast cell lines, Medical Research Council cell strain 5 (MRC-5) and HF19 cells frequently used on experimental studies regarding allergic and respiratory disorders. The human lung fibroblasts were stimulated with house dust mite (Der p1) or tumor necrosis factor alpha (TNF-α) for 24 h, and we quantified TRPA1 mRNA and protein by qRT-PCR and western blot analysis, respectively. TRPA1 mRNA expressions were upregulated after TNF-α treatment. Calcium imaging analysis revealed that TNF-α treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist all...
Source: Cytokine - February 9, 2020 Category: Molecular Biology Authors: Yap JMG, Ueda T, Takeda N, Fukumitsu K, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Kanemitsu Y, Niimi A Tags: Cytokine Source Type: research

Identification of TNFA influencing MDD risk and clinical features in Han Chinese.
In this study, we hypothesized that TNFA is risk factor to MDD, and TNFA rs1799724 polymorphism may be a susceptibility locus for this disorder and its clinical features. METHODS: We enrolled 807 MDD samples and 822 healthy volunteers in Eastern China. There were 104 drug-naïve first episode MDD patients recruited. The Hamilton Rating Scale for Depression -17 (HRSD-17) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were performed to evaluate the severity of depressive symptoms and cognitive function, respectively. RESULTS: Patients with MDD have higher levels of TNFA than heal...
Source: Cytokine - February 8, 2020 Category: Molecular Biology Authors: Zhao J, Hua S, Wang W, Fan W, Tang W, Zhang Y, Zhang C Tags: Cytokine Source Type: research

Bevacizumab has bidirectional regulatory effects on the secretion of basic fibroblast growth factor in glioma cells.
This study reported that anti-VEGF treatment regulated bFGF secretion in a double-edged manner. That is, moderate VEGF neutralization reduced bFGF production, whereas VEGF overblocking enhanced bFGF secretion in glioma cells. Our data provide a new perspective on the treatment of glioma with anti-VEGF, and the underlying mechanism is worthy of further study. PMID: 32044668 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - February 7, 2020 Category: Molecular Biology Authors: Wei P, Zhang Z, Lin M, Zhou B, Wang Z Tags: Cytokine Source Type: research

Pro-inflammatory cytokines, oxidative stress and diffuse coronary reocclusions in elderly patients after coronary stenting.
Abstract BACKGROUND: The inflammation responses and oxidative stress were closely associated with coronary heart disease. We tried to evaluate the effects of multiple stents, long stents and small-diameter stents on inflammation responses and oxidative stress in the elderly patients with long diffuse reocclusions. METHODS: The blood samples were obtained after an overnight fast and we evaluated the expression levels of soluble ST2 (sST2), acrolein (ACR), aldosterone (ALD), angiotensin II (Ang II), toll-like receptor 4 (TLR4), tumour necrosis factor-α (TNF-α), malondialdehyde (MDA) and high sensiti...
Source: Cytokine - February 7, 2020 Category: Molecular Biology Authors: Li X, Guo D, Zhou H, Hu Y, Fang X, Chen Y, Zhang F Tags: Cytokine Source Type: research

Cross-talk between SUMOylation and ISGylation in response to interferon.
Abstract Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to profile global changes in protein abundance in SUMO3-expressing cells stimulated by IFNα. These analyses revealed the stabilization of several ISG factors including SAMHD1, MxB, GBP1, GBP5, Tetherin/BST2 and members of IFITM, IFIT and IFI families. This process was correlated with enhan...
Source: Cytokine - February 7, 2020 Category: Molecular Biology Authors: El-Asmi F, McManus FP, Brantis-de-Carvalho CE, Valle-Casuso JC, Thibault P, Chelbi-Alix MK Tags: Cytokine Source Type: research

Neutrophilic granule protein (NGP) attenuates lipopolysaccharide-induced inflammatory responses and enhances phagocytosis of bacteria by macrophages.
In this study, we observed a significant increase of NGP in peritoneal macrophages (PMs) isolated from mice challenged with E. coli or lipopolysaccharide (LPS), as judged by NGP mRNA microarray. We also found changes in NGP to be mainly Toll-like receptor 4 (TLR4)-dependent. By western blot and electrophoretic mobility shift assay, we demonstrated NGP overexpression to reduce TNF-α and IL-1β production by LPS-induced RAW264.7 cells (RAW) via suppression of the NF-κB (p65 and p50) signalling pathway, rather than the JNK1/AP-1 (fos and jun) signalling pathway. NGP overexpression by LPS-induced RAW also induc...
Source: Cytokine - February 5, 2020 Category: Molecular Biology Authors: Liu K, Tian LX, Tang X, Wang J, Tang WQ, Ma ZF, Chen T, Liang HP Tags: Cytokine Source Type: research

Tissue Transglutaminase contributes to myelin phagocytosis in interleukin-4-treated human monocyte-derived macrophages.
am AM Abstract Macrophages exert either a detrimental or beneficial role in Multiple Sclerosis (MS) pathology, depending on their inflammatory environment. Tissue Transglutaminase (TG2), a calcium-dependent cross-linking enzyme, has been described as a novel marker for anti-inflammatory, interleukin-4 (IL-4) polarized macrophages (M(IL-4)), which represent a subpopulation of macrophages with phagocytic abilities. Since TG2 is expressed in macrophages in active human MS lesions, we questioned whether TG2 drives the differentiation of M(IL-4) into an anti-inflammatory phenotype and whether it plays a role in the pha...
Source: Cytokine - February 4, 2020 Category: Molecular Biology Authors: Sestito C, Brevé JJP, Bol JGJM, Wilhelmus MMM, Drukarch B, van Dam AM Tags: Cytokine Source Type: research