A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation.
Abstract Cytokines, growth factors or hormones take action through the JAK/STAT5 signaling pathway, which plays a critical role in regulating the intestinal response to infection and inflammation. However, the way in which STAT5 regulates intestinal epithelial compartment is largely ignored due to the lack of genetic tools for proper exploration and because the two STAT5 transcription factors (STAT5A and STAT5B) have some redundant but also distinct functions. In this review article, by focusing on STAT5 functions in the intestinal undifferentiated and differentiated epithelia, we discuss major advances of the gro...
Source: Cytokine - January 19, 2021 Category: Molecular Biology Authors: Surbek M, Tse W, Moriggl R, Han X Tags: Cytokine Source Type: research
Phloridzin attenuates lipopolysaccharide-induced cognitive impairment via antioxidant, anti-inflammatory and neuromodulatory activities.
CONCLUSIONS: Phloridzin may have neuroprotective role against LPS-induced neuroinflammation and memory impairment by virtue of its antioxidant, anti-inflammatory, and enhanced cholinergic signalling activity in the hippocampus and cerebral cortex. PMID: 33476914 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - January 18, 2021 Category: Molecular Biology Authors: Kamdi SP, Raval A, Nakhate KT Tags: Cytokine Source Type: research
Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary.
In conclusion, visfatin inhibits the proliferation and apoptosis without modulating the ovarian steroid biosynthesis and visfatin mediated BCL2 expression could also be mechanism to preserve the good quality follicle in early postnatal period. PMID: 33476980 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - January 18, 2021 Category: Molecular Biology Authors: Annie L, Gurusubramanian G, Kumar Roy V Tags: Cytokine Source Type: research
p53 affects epigenetic signature on SOCS1 promoter in response to TLR4 inhibition.
Abstract Suppressor of cytokine signaling (SOCS1) functions as a negative regulator of toll-like receptor (TLR) induced inflammatory signaling. As silencing of SOCS1 is concomitant with elevated TLR4 levels in glioblastoma, we investigated the effect of TLR4 inhibition on SOCS1 expression. Pharmacological inhibition of TLR4 signaling by TAK242 or its siRNA-mediated knockdown in p53 mutant or wild-type glioma cells resulted in either increased or decreased SOCS1 expression and promoter activity, respectively. Genetic manipulation of p53 indicated that SOCS1 expression upon TLR4 inhibition is dependent on p53 mutati...
Source: Cytokine - January 18, 2021 Category: Molecular Biology Authors: Sheikh T, Sen E Tags: Cytokine Source Type: research
Association of Interleukin-10 -592 C > A gene polymorphism with coronary artery disease: A case-control study and meta-analysis.
CONCLUSION: Although our research findings support a significant association of genetic polymorphism in the IL10 gene with cardiovascular diseases, this finding cannot be confirmed in meta-analysis. Further functional analysis and evaluation of this marker in a multicenter setting are needed to establish its value as a risk stratification marker. PMID: 33472122 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - January 17, 2021 Category: Molecular Biology Authors: Ghalandari M, Jamialahmadi K, Nik MM, Pirhoushiaran M, Mirhafez SR, Rooki H, Avan A, Ghazizadeh H, Moohebati M, Nohtani M, Zaimkohan H, Ferns GA, Pasdar A, Ghayour-Mobarhan M Tags: Cytokine Source Type: research
Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - In vitro and in vivo results.
CONCLUSIONS: GMA may regulate the immune system in patients with an immune-mediated disorder by inducing a biological response of neutrophils with a PICD-like reaction. PMID: 33395614 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - January 1, 2021 Category: Molecular Biology Authors: Kashiwagi N, Saito F, Maegawa H, Kaneda K Tags: Cytokine Source Type: research
Effects of moderate exercise on lipopolysaccharide-induced inflammatory responses in rat's cardiac tissue.
Abstract The effects of moderate exercise on cardiac tissue inflammation, oxidative stress markers and apoptosis in lipopolysaccharide (LPS)-administered rats were evaluated. Wistar rats were divided into three groups (N = 8): (1) control; (2) LPS (1 mg/kg); and (3) LPS + moderate training (LPS + EX: 15 m/min, 30 min/day, for 9 weeks (week 1-9)). LPS was injected intraperitoneally for 5 days during week 9. Finally, the rats' heart were removed for biochemical and expression assessments. LPS increased the levels of tumor necrosis factor α (TNF-α), i...
Source: Cytokine - December 23, 2020 Category: Molecular Biology Authors: Khoshkhouy F, Farshbaf A, Mahmoudabady M, Gholamnezhad Z Tags: Cytokine Source Type: research
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1 α pathway in human IL-8-expressing mice.
In this study, we used hydrodynamic injection to deliver the liver-specific expression vector pLIVE-hIL-8 into mice. We found that hIL-8 can exacerbate alcohol-induced fatty liver disease via the Akt/HIF-1α pathway. Exacerbated liver lipid degeneration in mice, which is characterized by excessive accumulation of triglycerides, and liver damage markers were significantly increased. Moreover, hIL-8 could increase the alcohol-induced release of ROS in fatty liver caused by alcohol and exacerbate fatty liver disease. The expression of liver lipid metabolism-related gene sterol regulatory element-binding protein-1c (SREBP...
Source: Cytokine - December 19, 2020 Category: Molecular Biology Authors: Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y Tags: Cytokine Source Type: research
ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection.
Abstract Bloodstream infection (BSI) is usually accompanied with the changes of varieties of inflammation proteins. In our previous study, we identified that inter-α-trypsin inhibitor heavy chain H4 (ITIH4) was highly expressed in the infection arms than the normal control arm. However, the correlated verification and mechanism remain obscure. Escherichia coli infected mice model and clinical serum samples were used to validate the concentration of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), as well as ITIH4, in ELISA method. Cytokines (IL-6, TNF-α, IL-10 ...
Source: Cytokine - December 18, 2020 Category: Molecular Biology Authors: Ma Y, Li R, Wang J, Jiang W, Yuan X, Cui J, Wang C Tags: Cytokine Source Type: research
Altered plasma levels of βC and γC chain cytokines and post-treatment modulation in tuberculous lymphadenitis.
CONCLUSIONS: Hence, we conclude that altered plasma levels of βC and γC cytokines are the characteristics of immune alteration in TBL disease and certain cytokines were modulated after treatment. PMID: 33341600 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - December 17, 2020 Category: Molecular Biology Authors: Kathamuthu GR, Moideen K, Sridhar R, Baskaran D, Babu S Tags: Cytokine Source Type: research
Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage.
CONCLUSIONS: We investigated the cytokine characteristics of both amniotic fluid and cord blood in gastroschisis, and found that certain cytokines could affect the adverse outcomes, including fetal brain damage. These findings provide important information that could further clarify the pathophysiology of gastroschisis and propose a novel clinical implication of gastroschisis that could be used to predict adverse outcomes, especially neurodevelopmental disorders. PMID: 33341000 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - December 16, 2020 Category: Molecular Biology Authors: Owaki T, Imai K, Miki R, Niwa Y, Kotani T, Nakano-Kobayashi T, Ushida T, Kajiyama H Tags: Cytokine Source Type: research
The IL-33/ST2 pathway is not essential to Th2 stimulation but is key for modulation and survival during chronic infection with Schistosoma mansoni in mice.
êa D Abstract Morbidity during chronic schistosomiasis has been associated with the induction and modulation of type-2 granulomatous inflammatory response induced by antigens secreted by the eggs, which become trapped in capillary venules of the host tissues, especially in the liver and intestines. IL-33, an alarmin released after cell damage, binds to its ST2 (suppressor of tumorigenicity 2) receptor, expressed in an variety of immune cells, including ILC2 and macrophages, and stimulates the early production of IL-5 and IL-13, which leads to eosinophil infiltration and activation of a Th2 response. However,...
Source: Cytokine - December 16, 2020 Category: Molecular Biology Authors: Maggi L, Rocha IC, Camelo GMA, Fernandes VR, Negrão-Corrêa D Tags: Cytokine Source Type: research
Suppression of lncRNA MALAT1 reduces pro-inflammatory cytokines production by regulating miR-150-5p/ZBTB4 axis through JAK/STAT signal pathway in systemic juvenile idiopathic arthritis.
This study aimed to explore the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and its mechanism in sJIA. We found that the expression of MALAT1, the plasma level of pro-inflammatory cytokines (IL-6, IL-17, IL-1β, and TNF-α) as well as MMP-8 and MMP-9 production were significantly elevated in sJIA patients. Moreover, we observed that the production of these cytokines in peripheral blood mononuclear cells (PBMCs) from sJIA patients were reduced after MALAT1 knockdown. Furthermore, bioinformatics analysis predicted that MALAT1 might bind to miR-150-5p and ZBTB4 was a downstream targ...
Source: Cytokine - December 16, 2020 Category: Molecular Biology Authors: Jiang H, Zhu M, Wang H, Liu H Tags: Cytokine Source Type: research
Lisofylline mitigates cardiac inflammation in a mouse model of obesity through improving insulin secretion and activating cardiac AMPK signaling pathway.
Abstract Obesity has emerged as a leading cause of death in the last few decades, mainly due to associated cardiovascular diseases. Obesity, inflammation, and insulin resistance are strongly interlinked. Lisofylline (LSF), an anti-inflammatory agent, demonstrated protection against type 1 diabetes, as well as reduced obesity-induced insulin resistance and adipose tissue inflammation. However, its role in mitigating cardiac inflammation associated with obesity is not well studied. Mice were divided into 4 groups; the first group was fed regular chow diet, the second was fed regular chow diet and treated with LSF, t...
Source: Cytokine - December 16, 2020 Category: Molecular Biology Authors: Ali M, Bakr MH, Abdelzaher LA, Sayed SA, Mali V, Desai AA, Radwan E Tags: Cytokine Source Type: research
Omentin-1 and vaspin serum levels in patients with pre-clinical carotid atherosclerosis and the effect of statin therapy on them.
Abstract BACKGROUND: Omentin-1 and vaspin are novel adipokines, and their association with atherosclerosis is still under investigation. The present study aimed to assess the relationship of those adipokines with preclinical, non-significant carotid atherosclerosis and the impact of statin therapy on their levels, suggesting a link between adiposity and atherosclerosis. METHODS: Eighty-four statin-free subjects with non-significant, preclinical carotid atherosclerosis and elevated LDL- cholesterol levels (>130 mg/dl) were recruited to receive atorvastatin (from 10 to 80 mg per day) (atorvastatin ...
Source: Cytokine - December 15, 2020 Category: Molecular Biology Authors: Kadoglou NPE, Kassimis G, Patsourakos N, Kanonidis I, Valsami G Tags: Cytokine Source Type: research
Cortisol and perceived stress are associated with cytokines levels in patients infected with influenza B virus.
co AG Abstract Influenza B virus (IBV) causes respiratory infectious disease. Cytokines are important immune mediators during infectious diseases. Cortisol and stress have been related to respiratory infection susceptibility and cytokine regulation. Little is known about systemic cytokines, cortisol, and perceived stress in the early stages of IBV infection. We researched the systemic cytokines and cortisol, as well as the perceived stress and blood cell count in patients infected with IBV. The diagnosis was established using the Luminex xTAG RVP kit and confirmed with qRT-PCR for IBV viral load. The perceived str...
Source: Cytokine - December 15, 2020 Category: Molecular Biology Authors: Lopez-Acevo CA, Arrendondo-Loza E, Salinas-Carmona MC, Rendon A, Martinez-Castilla AM, Vázquez-Marmolejo AV, Munoz-Maldonado G, Rosas-Taraco AG Tags: Cytokine Source Type: research
Regulation of macrophage subsets and cytokine production in leishmaniasis.
Abstract Macrophages are host cells for parasites of the genus Leishmania where they multiply inside parasitophorous vacuoles. Paradoxically, macrophages are also the cells responsible for killing or controlling parasite growth, if appropriately activated. In this review, we will cover the patterns of macrophage activation and the mechanisms used by the parasite to circumvent being killed. We will highlight the impacts of the vector bite on macrophage activation. Finally, we will discuss the ontogeny of macrophages that are infected by Leishmania spp. PMID: 33334669 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - December 14, 2020 Category: Molecular Biology Authors: Carneiro MB, Vaz LG, Afonso LCC, Horta MF, Vieira LQ Tags: Cytokine Source Type: research
Experience of using tocilizumab for treatment in Indonesian patients with severe COVID-19.
Abstract COVID-19 is a public health emergency of international concern with millions confirmed cases globally including in Indonesia with more than two hundred thousand confirmed cases to date COVID-19. (1) COVID-19 has wide clinical manifestation ranging from asymptomatic, acute respiratory illness, respiratory failure that necessitates mechanical ventilation and support in an ICU, to MODS. (2) Several comorbidities have been demonstrated to be associated with the development of severe outcomes from COVID-19 infection, such as hypertension, diabetes, cardiovascular disease, dyslipidemia, thyroid disease, and pul...
Source: Cytokine - December 14, 2020 Category: Molecular Biology Authors: Widysanto A, Kurniawan A, Lugito NPH, Yuniarti M, Gunawan C, Angela, Wiryanto J, Levinna, Pradhana TM Tags: Cytokine Source Type: research
Zinc supplementation is associated with a reduction in serum markers of inflammation and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials.
Abstract BACKGROUND: Zinc (Zn) is a trace metal that is considered to have an impact on chronic inflammation. However, findings of clinical trials have been inconsistent. The present systematic review and meta-analysis aimed to provide a more robust examination of the evidence on the effectiveness of Zn supplements on markers of inflammation and oxidative stress. METHODS: A systematic search in PubMed, Scopus, Web of Science and Cochrane Library was undertaken to identify relevant randomized controlled trials (RCTs) assessing the impact of Zn on inflammation and oxidative stress until 17 August 2020. We appli...
Source: Cytokine - December 14, 2020 Category: Molecular Biology Authors: Hosseini R, Ferns GA, Sahebkar A, Mirshekar MA, Jalali M Tags: Cytokine Source Type: research
Carvedilol prevents pancreatic β-cell damage and the development of type 1 diabetes in mice by the inhibition of proinflammatory cytokines, NF-κB, COX-2, iNOS and oxidative stress.
In conclusion, these findings suggest that carvedilol is able to prevent pancreatic β-cell damage and the development of T1D in mice by the inhibition of inflammatory and oxidative mediators. PMID: 33310423 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - December 9, 2020 Category: Molecular Biology Authors: Amirshahrokhi K, Zohouri A Tags: Cytokine Source Type: research
Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis.
This study suggests that TWEAK may have a role in the pathogenesis of PV, PP, and EP via synergy with IL-17A, IFN-γ, or IL-36γ, but not with IL-22. PMID: 33302223 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - December 8, 2020 Category: Molecular Biology Authors: Wang H, Wang S, Li L, Wang X, Liu C, Lu M, Xia Y, Liu Y Tags: Cytokine Source Type: research
Chemokines in Leishmaniasis: Map of cell movements highlights the landscape of infection and pathogenesis.
xeira-Carvalho A Abstract Pathogen interactions with the host immune response components are critical for establishing protective immunity and pathological responses against Leishmania parasites. A predominant proinflammatory profile associated with enhanced phagocytosis trigger a cell-mediated immune response that is relevant to infection control. On the other hand, an anti-inflammatory phenotype, correlated with a predominant modulated/regulatory response, favors intracellular proliferation of Leishmania parasites and disease progression. In this context, chemokines play an important role in determining cellular...
Source: Cytokine - December 7, 2020 Category: Molecular Biology Authors: de Araújo FF, Costa-Silva MF, Pereira AAS, Rêgo FD, Pereira VHS, de Souza JP, Fernandes LOB, Martins-Filho OA, Gontijo CMF, Peruhype-Magalhães V, Teixeira-Carvalho A Tags: Cytokine Source Type: research
Immuno-modulatory effects of methanolic extract of Ferula szowitsiana on isolated human Th1/Th2/Treg cytokines levels, and their genes expression and nitric oxide production.
Abstract BACKGROUND: Anti-inflammatory and anti-oxidants activities of Ferula szowitsiana L. (F. szowitsiana) were shown in ancient texts and assayed by modern studies. However, immunomodulatory properties of the plant are poorly understood. METHODS: The effects of F. szowitsiana extract (10, 40 and 160 µg/ml), dexamethasone and vehicle were investigated on nitric oxide (NO) level, cell proliferation, and cytokines (IL-4, IL10 and IFN-γ) expression at gene and protein levels in non-stimulated and phytohaemagglutinin-stimulated human lymphocytes (n = 15 in each group). RESULTS: ...
Source: Cytokine - December 2, 2020 Category: Molecular Biology Authors: Askari VR, Alavinezhad A, Rahimi VB, Rezaee SA, Boskabady MH Tags: Cytokine Source Type: research
Salivary concentrations of cytokines and other analytes in healthy children.
z-Moreno L, Torre-Bouscoulet L, Vargas MH Abstract BACKGROUND: Blood has been the usual biological fluid for measuring analytes, but there is mounting evidence that saliva may be also useful for detecting cytokines in a noninvasive way. Thus, in this study we aimed to determine concentration of cytokines and other analytes in saliva from a population of healthy children. METHODS: We collected un-stimulated whole saliva samples from clinically healthy children, and concentration of 17 cytokines and 12 other analytes were measured in supernatants. All values were adjusted by albumin content and were log-transfo...
Source: Cytokine - December 1, 2020 Category: Molecular Biology Authors: Chávez-Alderete J, Gochicoa-Rangel L, Del-Río-Hidalgo R, Guerrero-Zúñiga S, Mora-Romero U, Benítez-Pérez R, Rodríguez-Moreno L, Torre-Bouscoulet L, Vargas MH Tags: Cytokine Source Type: research
Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome.
Abstract Chinese tree shrews (Tupaia belangeri chinensis) are increasingly used as an alternative experimental animal to non-human primates in studying viral infections. Guanylate-binding proteins (GBP) belong to interferon (IFN)-inducible GTPases and defend the mammalian cell interior against diverse invasive pathogens. Previously, we identified five tree shrew GBP genes (tGBP1, tGBP2, tGBP4, tGBP5, and tGBP7) and found that tGBP1 showed antiviral activity against vesicular stomatitis virus (VSV) and type 1 herpes simplex virus (HSV-1) infections. Here, we showed that the anti-VSV activity of tGBP1 was independen...
Source: Cytokine - November 30, 2020 Category: Molecular Biology Authors: Gu T, Yu D, Xu L, Yao YL, Zheng X, Yao YG Tags: Cytokine Source Type: research
Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance.
Abstract During obesity adipose tissue abundantly secrete pro-inflammatory adipokines like Tumour Necrosis factor-alpha (TNFα), resistin, leptin, etc. but reduced anti-inflammatory adipokines like adiponectin, interleukin (IL)-10, and IL-4. In our recent clinical study, it was observed that both gene expressions and stored levels of resistin were elevated in adipose tissue of metabolically obese Indians. Resistin profoundly increases obesity, mitigates lipid metabolism, and causes peripheral insulin resistance. It dysregulates the metabolism of human adipocytes but, its effects on human adipose-derived mesen...
Source: Cytokine - November 30, 2020 Category: Molecular Biology Authors: Rawal K, Purohit KM, Patel TP, Karont N, Gupta S Tags: Cytokine Source Type: research
Porphyromonas gingivalis-Lipopolysaccharide induces cytokines and enzymes of the mouse cementoblasts.
Abstract Lipopolysaccharide is a potent virulence factor of Porphyromonas gingivalis and has been implicated predominant pathogen in the development and progression of periodontal diseases. The aim of this study was to determine the effect of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on cementoblasts. Cementoblast (OCCM-30) were evaluated proliferation using real-time cell analyzer. In addition, total RNA was isolated at 8, 16, 24 and 72 h from 1000 ng/mL Pg-LPS treated OCCM-30 cells and mRNA expressions of pro/anti-inflammatory cytokine mediators, extracellular matrix enzymes and their tissue...
Source: Cytokine - November 29, 2020 Category: Molecular Biology Authors: Bozkurt SB, Tuncer Gokdag I, Sezgin Hakki S Tags: Cytokine Source Type: research
Association of leptin receptor expression in placenta and peripheral blood mononuclear cell with maternal weight in birth outcomes.
CONCLUSIONS: LEPR expression level in maternal PBMC correlates with newborn measurements independent from sex. GWG can affect fetal development by increasing fetal birth weight. PMID: 33264748 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 29, 2020 Category: Molecular Biology Authors: Galindo-Cáceres MA, Parra-Unda R, Murillo-Llanes J, Morgan-Ortiz F, Rendón-Maldonado JG, Osuna-Espinoza KY, Osuna-Ramírez I Tags: Cytokine Source Type: research
Potential predictive value of change in inflammatory cytokines levels subsequent to initiation of immune checkpoint inhibitor in patients with advanced non-small cell lung cancer.
Abstract For a definite indication for immunotherapy, finding appropriate biomarkers that are predictive of treatment responses is necessary. Inflammatory cytokines which play critical roles in immunity against infectious sources or cancer cells are suggested to activate immune cells after initiation of immune checkpoint inhibitors (ICI). Through activation of immune cells such as T cells, natural killer cells, macrophages, or tumor infiltrating dendritic cells, inflammatory cytokines usually increase after programmed death (PD)-1/PD-L1 axis blockade. There have been several studies evaluating the predictive value...
Source: Cytokine - November 29, 2020 Category: Molecular Biology Authors: Lim JU, Yoon HK Tags: Cytokine Source Type: research
Macrophage-polarizing stimuli differentially modulate the inflammatory profile induced by the secreted phospholipase A2 group IA in human lung macrophages.
In conclusion, we demonstrated a fine-tuning modulation of svGIA-activated HLMs differentially exerted by the classical macrophage-polarizing cytokines. PMID: 33248911 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 25, 2020 Category: Molecular Biology Authors: Ferrara AL, Galdiero MR, Fiorelli A, Cristinziano L, Granata F, Marone G, Crescenzo RMD, Braile M, Marcella S, Modestino L, Varricchi G, Spadaro G, Santini M, Loffredo S Tags: Cytokine Source Type: research
Moderate aerobic training modulates cytokines and cortisol profiles in older adults with cognitive abilities.
Abstract Excessive expression of cortisol and pro-inflammatory cytokines exerts a negative affect on cognitive functioning and hippocampal structure in older adults. Although the interrelation between cortisol and cytokines was fully elucidated previously, few studies considered how their association with exercise can affect brain structures or play an anti-inflammatory role in preserving cognitive function among older adults. To evaluate both the neuro-protective and anti-inflammatory activities of moderate aerobic exercise in improving cognitive performance among healthy older adults, the serum levels of CRP, TN...
Source: Cytokine - November 25, 2020 Category: Molecular Biology Authors: Alghadir AH, Gabr SA, Al-Momani M, Al-Momani F Tags: Cytokine Source Type: research
Potential emerging roles of the novel adipokines adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis interplay.
CONCLUSIONS: Metrnl, and to a lesser extent adipolin seem to be interrelated with OA. Different in-context regulatory mechanisms for metrnl production from various tissues are strongly suggested. Importantly, the findings of the current study shed lights on metrnl as a potential novel mediator and therapeutic target to consider in obesity-OA interplay. PMID: 33248913 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 25, 2020 Category: Molecular Biology Authors: Sobieh BH, Kassem DH, Zakaria ZM, El-Mesallamy HO Tags: Cytokine Source Type: research
Defective immunosuppressive function of Treg cells in visceral adipose tissue in MIF deficient mice.
In this study we demonstrate that the absence of the pro-inflammatory cytokine MIF led to obesity and inflammation in the visceral AT (VAT) in 6 months old MIF-/- mice. Besides the increment of pro-inflammatory AT macrophages and the enhanced production of TNF and IL-1β, VAT of MIF-/- mice contained increased numbers of Treg cells. In situ proliferation of Treg cells did not differ between MIF-/- and wild type mice, but Treg cells isolated from the VAT of MIF-deficient mice, and not from the cervical lymph nodes, exhibited lower expression and production of IL-10 and TGF-β. Additionally, SVF cells had signif...
Source: Cytokine - November 24, 2020 Category: Molecular Biology Authors: Gajic D, Koprivica I, Stojanovic I, Saksida T Tags: Cytokine Source Type: research
Rapid changes in serum IL-6 levels in preterm newborns with Gram-negative early-onset sepsis.
Abstract Early-onset sepsis (EOS) remains a leading cause of morbidity and mortality for newborns, especially in preterm birth. Serum IL-6 levels are used as an accurate marker for EOS; however, no study has focused on the changes in serum IL-6 levels in newborns with EOS. Here, we investigated 6 preterm newborns (23.4-28.2 wks' gestational age) with birthweights of 570-1080 g who were diagnosed with EOS. All newborns received active treatment, including exchange transfusions and/or polymyxin B-immobilized fiber column direct hemoperfusion for septic shock. In the 3 surviving newborns, serum-IL-6 levels peake...
Source: Cytokine - November 23, 2020 Category: Molecular Biology Authors: Kobayashi T, Iwatani S, Hirata A, Yamamoto M, Yoshimoto S Tags: Cytokine Source Type: research
Wnt3a upregulation is involved in TGF β1-induced cardiac hypertrophy.
Wnt3a upregulation is involved in TGFβ1-induced cardiac hypertrophy. Cytokine. 2020 Nov 23;:155376 Authors: Li T, Weng X, Cheng S, Wang D, Cheng G, Gao H, Li Y Abstract Pathological cardiac hypertrophy, characterized by enlarged cell size and fetal gene reactivation, ultimately leads to cardiac dysfunction and heart failure. The expression of transforming growth factor beta 1 (TGFβ1) is often elevated in experimental models of cardiac hypertrophy. In the present study, we observed the activation of Wnt/β-catenin signaling in TGFβ1-induced cardiac hypertrophy. TGFβ1 stimulation...
Source: Cytokine - November 23, 2020 Category: Molecular Biology Authors: Li T, Weng X, Cheng S, Wang D, Cheng G, Gao H, Li Y Tags: Cytokine Source Type: research
Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4+ T cell subsets.
In this study, alterations in immunomodulatory abilities of MSCs caused by aging were investigated. For this, dental pulp (DP) MSCs and peripheral blood mononuclear cells (PBMCs) of elderly and young donors were co-cultured age-matched and cross. We detected that the effects of DP-MSCs on Th1 and Th2 cells and their specific cytokines IFN-γ and IL-4 are not affected by aging. However, we observed that young and elderly DP-MSCs have different effects on Th17 and Treg cells. Th17 frequencies of young and elderly PBMCs were significantly increased only by young DP-MSCs, in contrast, Treg frequencies were significantly i...
Source: Cytokine - November 19, 2020 Category: Molecular Biology Authors: Özgül Özdemir RB, Özdemir AT, Kırmaz C, Eker Sarıboyacı A, Karaöz E, Erman G, Vatansever HS, Mete Gökmen N Tags: Cytokine Source Type: research
Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches.
This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2...
Source: Cytokine - November 19, 2020 Category: Molecular Biology Authors: da Silva FRP, Pessoa LDS, Shin JI, Alves EHP, Koga RS, Smith CV, Vasconcelos DFP, Pereira ACTDC Tags: Cytokine Source Type: research
Short-term effect of non-surgical periodontal treatment on local and systemic cytokine levels: Role of hyperglycemia.
Abstract BACKGROUND: The effect of non-surgical periodontal treatment on oral and systemic inflammatory mediators in subjects with periodontitis and hyperglycemia remains largely unknown. Therefore, the aim of this clinical study was to compare the short-term effect of non-surgical periodontal treatment on serum, saliva and GCF inflammatory markers levels in GP subjects with or without hyperglycemia. METHODS: Sixty subjects divided into four groups of equal size were selected to participate: type 2 diabetics with generalized periodontitis (T2DM + GP), pre-diabetics with GP (PD + GP), normo...
Source: Cytokine - November 18, 2020 Category: Molecular Biology Authors: Rabelo MS, Gomes GH, Foz AM, Stadler AF, Cutler CW, Susin C, Romito GA Tags: Cytokine Source Type: research
Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus.
CONCLUSION: UP is a complex and multifactorial problem. In patients with UP the high levels of IL-31 indicates a possible role in pathogenesis. IL-13 serum level on the other hand may be related to the severity of itch in these patients. Optimizing dialysis and targeting these cytokines may provide a potential therapeutic option especially in refractory UP. Further studies addressing these cytokines and their levels in response to various treatments may provide additional information on UP. PMID: 33221158 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 18, 2020 Category: Molecular Biology Authors: Oweis AO, Al-Qarqaz F, Bodoor K, Heis L, Alfaqih MA, Almomani R, Obeidat MA, Alshelleh SA Tags: Cytokine Source Type: research
Cytokine profiles in patients with newly diagnosed multiple myeloma: Survival is associated with IL-6 and IL-17A levels.
CONCLUSIONS: Cytokine deregulation, especially that of IL-6 and IL-17A, may be a powerful predictor of clinical prognosis for MM patients. PMID: 33183958 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 10, 2020 Category: Molecular Biology Authors: Gu J, Huang X, Zhang Y, Bao C, Zhou Z, Jin J Tags: Cytokine Source Type: research
Rs-1884444 G/T variant in IL-23 receptor is likely to modify risk of bladder urothelial carcinoma by regulating IL-23/IL-17 inflammatory pathway.
Abstract Bladder urothelial carcinoma (BUC) is a chronic relapsing urological malignancy, which poses a serious threat to human life. Non-resolving chronic-inflammation at the neoplastic site is associated consistently with inducing tumor-progression and poor patient outcomes. Interleukin 23 receptor (IL-23R) is a key element in T-helper 17 cell-mediated inflammatory process, that plays a critical role in orchestrating tumor-promoting inflammation. Therefore, we hypothesized that potentially functional genetic variant rs1884444 G/T of IL-23R may modify BUC risk. To validate this hypothesis, our findings demonstrat...
Source: Cytokine - November 10, 2020 Category: Molecular Biology Authors: El-Gedamy M, El-Khayat Z, Abol-Enein H, El-Said A, El-Nahrery E Tags: Cytokine Source Type: research
Oxycodone attenuates vascular leak and lung inflammation in a clinically relevant two-hit rat model of acute lung injury.
CONCLUSION: Oxycodone pretreatment appears to act via κ- and μ-opioid receptors to ameliorate LPS- and MV-induced lung injury by suppressing inflammation and apoptosis, and this protective effect might be mediated through the inhibition of the TLR4/NF-κB pathways. PMID: 33187816 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 10, 2020 Category: Molecular Biology Authors: Li X, Li R, Fang Q, Jamal M, Wang C, Wang Y, Zhang Z, Wu X, Song X Tags: Cytokine Source Type: research
Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1/2 and PI3K signals.
Abstract Our previous study showed that dizocilpine (MK-801) induced schizophrenia-like behavior in rats, enhanced GFAP expression, and activated primary cultured hippocampal astrocytes. Astrocytes play an essential role in neuroinflammation and contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases. However, the effects of MK-801 treatment on astrocytic neuroinflammatory responses and its mechanism of action have not been studied in detail. To address this issue, IL1β, IL6, TNFα and IL10 expression and secretion levels were evaluated in hippocampal astrocytes in ...
Source: Cytokine - November 10, 2020 Category: Molecular Biology Authors: Zhu H, Yang Y, Zhu M, Shi X, Ye L, Zhang S, Fang H, Yu W Tags: Cytokine Source Type: research
Single nucleotide polymorphisms within NFKBIA are associated with nasopharyngeal carcinoma susceptibility in Chinese Han population.
Abstract Genes involved in latent membrane protein 1 (LMP1) signaling pathways have been suggested to play an important role in nasopharyngeal carcinogenesis. We investigated potentially functional genetic variants associated with the risk of nasopharyngeal carcinoma (NPC) in genes involved in the LMP1 signaling pathway. Altogether, 73 single nucleotide polymorphisms (SNPs) with MAF ≥ 10% were located within the regions of interest of the four genes TRAF3, NFKBIA, CHUK and MAP2K4. From these, 10 SNPs were selected for genotyping based on LD (r2 ≥ 0.80) in a hospital-based case-control stu...
Source: Cytokine - November 5, 2020 Category: Molecular Biology Authors: Zhang H, Deng S, Zhang J, Zhu G, Zhou J, Ye W, Wang Q, Wang Y, Zou B, Zhang P, Zhang S, Lang J, Lu S Tags: Cytokine Source Type: research
In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF- β1-induced collagen gel contraction.
In conclusion, IFN-β through STAT1 and STAT2 shows antifibrotic effects on CF TGF-β1-treated, whereas STAT3 did not participate in such effect. PMID: 33160814 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - November 4, 2020 Category: Molecular Biology Authors: Bolivar S, Espitia-Corredor JA, Olivares-Silva F, Valenzuela P, Humeres C, Anfossi R, Castro E, Vivar R, Salas-Hernández A, Pardo-Jiménez V, Díaz-Araya G Tags: Cytokine Source Type: research
Exploring the extensive crosstalk between the antagonistic cytokines- TGF- β and TNF-α in regulating cancer pathogenesis.
Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis. Cytokine. 2020 Nov 03;:155348 Authors: Dash S, Sahu AK, Srivastava A, Chowdhury R, Mukherjee S Abstract A plethora of cytokines are produced in the tumor microenvironment (TME) those play a vital role in cancer prognosis. Though it is completely contextual, cytokines produced from an inflammatory micro-environment can either modulate cancer progression at early stages of tumor development or in later stages cytokine derived cues can in turn control tumor cell invasion and...
Source: Cytokine - November 3, 2020 Category: Molecular Biology Authors: Dash S, Sahu AK, Srivastava A, Chowdhury R, Mukherjee S Tags: Cytokine Source Type: research
Synergistic induction of IL-23 by TNF α, IL-17A, and EGF in keratinocytes.
In this study, we demonstrated that IL-23 production is induced by a combination of TNFα and IL-17A in human keratinocytes. Additionally, this IL-23 induction by TNFα and IL-17A is further increased in psoriatic keratinocytes and is enhanced by EGFR signaling. Although IL-23 is also robustly induced by toll-like receptor agonists in dendritic cells and macrophages, IL-23 expression in these cell types is not regulated by TNFα, IL-17A, and EGFR signaling. Given that IL-23 is essential for maintaining Th17 activation, IL-23 induction by TNFα, IL-17A, and EGF in keratinocytes could play an important pa...
Source: Cytokine - November 2, 2020 Category: Molecular Biology Authors: Ehst B, Wang Z, Leitenberger J, McClanahan D, De La Torre R, Sawka E, Ortega-Loayza AG, Strunck J, Greiling T, Simpson E, Liu Y Tags: Cytokine Source Type: research
A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis.
Abstract Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that in...
Source: Cytokine - October 31, 2020 Category: Molecular Biology Authors: Medara N, Lenzo JC, Walsh KA, Reynolds EC, Darby IB, O'Brien-Simpson NM Tags: Cytokine Source Type: research
Interplay of pro-inflammatory cytokines, pro-inflammatory microparticles and oxidative stress and recurrent ventricular arrhythmias in elderly patients after coronary stent implantations.
In this study, we included 613 consecutive elderly patients with recurrent ventricular arrhythmias induced by coronary reocclusions after coronary stenting. We measured CD31+ endothelial microparticle (CD31+EMP), CD62E+ endothelial microparticle (CD62E+EMP), high-sensitivity C-reactive protein (hs-CRP), aldosterone (ALD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), soluble tumor necrosis factor receptor-1 (sTNFR-1) and soluble tumor necrosis factor receptor-2 (sTNFR-2) in elderly patients with recurrent VA and assessed impacts of pro-inflammatory microparticles, pro-inflammatory cytokines and oxidat...
Source: Cytokine - October 30, 2020 Category: Molecular Biology Authors: Li X, Guo D, Zhou H, Hu Y, Fang X, Chen Y Tags: Cytokine Source Type: research
Respiratory syncytial virus upregulates IL-33 expression in mouse model of virus-induced inflammation exacerbation in OVA-sensitized mice and in asthmatic subjects.
CONCLUSION: The present study provides additional evidence of the crucial role of the IL-33 in pathogenesis of RSV infection and virus-induced allergic bronchial asthma exacerbations. PMID: 33132030 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - October 29, 2020 Category: Molecular Biology Authors: Nikonova A, Shilovskiy I, Galitskaya M, Sokolova A, Sundukova M, Dmitrieva-Posocco O, Mitin A, Komogorova V, Litvina M, Sharova N, Zhernov Y, Kudlay D, Dvornikov A, Kurbacheva O, Khaitov R, Khaitov M Tags: Cytokine Source Type: research