Clinical association between pre-treatment levels of plasma fibrinogen and bone metastatic burden in newly diagnosed prostate cancer patients.
In this study, we evaluated the correlation between pre-treatment plasma fibrinogen and the burden of bone metastasis in newly diagnosed PCa patients. METHODS: A single-center retrospective analysis, focusing on prostate biopsies of newly diagnosed PCa patients, was performed. A total of 261 patients were enrolled in this study in a 4-year period. All subjects were submitted to single-photon emission computerized tomography-computed tomography to confirm the status of bone metastasis and, if present, the number of metastatic lesions would then be calculated. Clinical information such as age, prostate-specific antigen ...
Source: Chinese Medical Journal - November 12, 2019 Category: General Medicine Authors: Xie GS, Li G, Li Y, Pu JX, Huang YH, Li JH, Yin HM Tags: Chin Med J (Engl) Source Type: research
Safety of High-Intensity Statins in the Veteran Population: Atorvastatin 40 to 80 mg Compared With Rosuvastatin 20 to 40 mg.
Abstract Background: High-intensity statin therapy is recommended in patients with clinical atherosclerotic cardiovascular disease (ASCVD) or at high risk of ASCVD. Current evidence demonstrates efficacy of high-intensity statin therapy in reducing major adverse cardiovascular events; yet the comparative safety profile between high-intensity statin agents remains unknown. In 2011, when atorvastatin became generic, the Veteran's Health Administration made the formulary switch from rosuvastatin to atorvastatin. Currently, rosuvastatin is generic; however, at the time of this study, it was still under patent. Objecti...
Source: The Annals of Pharmacotherapy - November 12, 2019 Category: Drugs & Pharmacology Authors: Stein B, Ward T, Hale G, Lyver E Tags: Ann Pharmacother Source Type: research
Efficacy of Antidepressants in the Treatment of Obstructive Sleep Apnea Compared to Placebo. A Systematic Review with Meta-Analyses.
Abstract PURPOSE: To establish the efficacy of oral antidepressants compared to placebo in improving obstructive sleep apnea (OSA) as measured on a polysomnography study. Secondary outcomes included self-reported sleepiness. METHODS: Authors identified prospective randomized placebo-controlled studies from MEDLINE through PubMed, Web of Science, the Cochrane Library and EMBASE up to February 2019 in English language. Antidepressants included tricyclic antidepressants (TCA), tetracyclic antidepressants (TeCA), selective serotonin reuptake inhibitors (SSRI), and serotonin receptor modulators (SRM). Studies were...
Source: Sleep and Breathing - November 12, 2019 Category: Sleep Medicine Authors: AbdelFattah MR, Jung SW, Greenspan MA, Padilla M, Enciso R Tags: Sleep Breath Source Type: research
Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections.
This study did not identify any statistically significant trend in the strains of RSV and S. pneumoniae associated with co-infections. Furthermore, almost all isolates (22 of 23) showed significantly increased adherence to RSV-infected cells. The level of adherence did not appear to correlate with pneumococcal strain or sequence type, and isolates obtained from RSV-infected patients displayed a similar level of adherence as those from RSV-negative patients. The absence of particular S. pneumoniae or RSV strains associated with co-infection, together with the near ubiquitous presence of RSV-mediated adhesion throughout the ...
Source: Microbiology - November 12, 2019 Category: Microbiology Authors: Brealey JC, Sly PD, Young PR, Chappell KJ Tags: Microbiology Source Type: research
Palliative Care for Patients With Hematologic Malignancies in a Low-Middle Income Country: Prevalence of Symptoms and the Need for Improving Quality of Attention at the End of Life.
CONCLUSIONS: Palliative care was provided to a minority of patients with hematologic malignancies and considerable improvement is required in its timely use and extension. PMID: 31714147 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)
Source: The American Journal of Hospice and Palliative Care - November 12, 2019 Category: Palliative Care Authors: Jaime-Pérez JC, Turrubiates-Hernández GA, Nava-Obregón T, Coronado-Hernández B, Gutiérrez-Aguirre H, Cantú-Rodríguez OG, Herrera-Garza JL, Gómez-Almaguer D Tags: Am J Hosp Palliat Care Source Type: research
The Dynamic Relationship between Asthma and Obesity in School Children.
In conclusion, childhood asthma drives an increase in the onset of obesity among school children, while the onset of obesity does not necessarily imply the future onset of asthma at least in the short term. PMID: 31712801 [PubMed - as supplied by publisher] (Source: Am J Epidemiol)
Source: Am J Epidemiol - November 12, 2019 Category: Epidemiology Authors: Zhang Y, Chen Z, Berhane K, Urman R, Chatzi VL, Breton C, Gilliland FD Tags: Am J Epidemiol Source Type: research
Predictors of fatal outcomes in pedestrian accidents in Tabriz Metropolis of Iran: Application of PLS-DA method.
Conclusions: The results show that predictors of a fatal outcome in pedestrian accidents in Tabriz can be attributed to the pedestrian characteristics (which notably account for differences in vulnerability in case of an accident), the car and driver features, and weather (which may all notably influence the amount of energy involved in the collision, through the car mass, speed, and conditions delaying the braking response or reducing the braking effectiveness). Regarding the statistical method, the PLS-DA is a powerful method which can be used to analyze high dimension data with multicollinearity issue. PMID: 317141...
Source: Traffic Injury Prevention - November 12, 2019 Category: Accident Prevention Authors: Jamali-Dolatabad M, Sadeghi-Bazargani H, Sarbakhsh P Tags: Traffic Inj Prev Source Type: research
Newly Credentialed Athletic Trainers' Perceptions of Their Transition to Practice.
Abstract CONTEXT: Newly credentialed athletic trainers (ATs) have reported stress and role ambiguity during the transition to practice. Previous researchers focused on their qualitative experiences, yet no investigators have explored how characteristics such as the setting or type of educational program affect the transition to practice. OBJECTIVE: To determine how newly credentialed ATs perceived their transition to practice. DESIGN: Cross-sectional study. SETTING: Online survey. PATIENTS OR OTHER PARTICIPANTS: Of 1835 newly credentialed ATs (18%) certified and employed between January and Sep...
Source: J Athl Train - November 12, 2019 Category: Sports Medicine Authors: Thrasher AB, Walker SE Tags: J Athl Train Source Type: research
Buccal hemineglect: is it useful to evaluate the differences between the two halves of the oral cavity for the multidisciplinary rehabilitative management of right brain stroke survivors? A cross-sectional study.
Buccal hemineglect: is it useful to evaluate the differences between the two halves of the oral cavity for the multidisciplinary rehabilitative management of right brain stroke survivors? A cross-sectional study. Top Stroke Rehabil. 2019 Nov 12;:1-7 Authors: de Sire A, Baricich A, Ferrillo M, Migliario M, Cisari C, Invernizzi M Abstract Background: Unilateral spatial neglect (USN) is the most frequent cognitive impairment after right brain stroke, characterized by inattention to sensory stimuli in the opposite hemispace. It has been recently hypothesized a novel condition defined as "buccal ...
Source: Topics in Stroke Rehabilitation - November 12, 2019 Category: Neurology Authors: de Sire A, Baricich A, Ferrillo M, Migliario M, Cisari C, Invernizzi M Tags: Top Stroke Rehabil Source Type: research
Is 123I-MIBG Scintigraphy Beneficial or Excessive for the Diagnosis of Parkinson's Disease in the Early Phase?
Abstract INTRODUCTION/OBJECTIVE: In most cases, abnormal cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy increases the probability of a diagnosis of Parkinson's disease (PD) in patients with parkinsonian features. In our study, we validated the additional value of 123I-MIBG scintigraphy beyond providing information on neurological findings and response to dopaminergic therapy for the diagnosis of PDin the early phase. METHODS: We investigated 77 cases of PD (Hoehn and Yahr Stages I-III) and 73 cases of atypical parkinsonian disorder (APD), including 35 patients with multiple system atrophy, 19 with ...
Source: Neuro-Degenerative Diseases - November 12, 2019 Category: Neurology Authors: Ikeda T, Ikenoshita S, Sakamoto F, Shiraishi S, Nakahara K, Masuda T, Yamashita S Tags: Neurodegener Dis Source Type: research
Preoperative intervention with long ‐acting bronchodilators for the reduction of postoperative pulmonary complications in untreated patients with obstructive lung disease
ConclusionThere is a limited benefit of preoperative treatment with inhaled LAB for the reduction of PPC in patients with untreated OLD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 12, 2019 Category: Respiratory Medicine Authors: Yu Mikami, Taisuke Jo, Hirotaka Matsuzaki, Taro Ishimori, Minako Saito, Yukiyo Sakamoto, Yasuhiro Yamauchi, Daiya Takai, Yutaka Yatomi, Takahide Nagase Tags: ORIGINAL ARTICLE Source Type: research
Improving risk prediction in heart failure using machine learning
ConclusionsUsing machine learning and readily available variables, we generated and validated a mortality risk score in patients with HF that was more accurate than other risk scores to which it was compared. These results support the use of this machine learning approach for the evaluation of patients with HF and in other settings where predicting risk has been challenging. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - November 12, 2019 Category: Cardiology Authors: Eric D. Adler, Adriaan A. Voors, Liviu Klein, Fima Macheret, Oscar O. Braun, Marcus A. Urey, Wenhong Zhu, Iziah Sama, Matevz Tadel, Claudio Campagnari, Barry Greenberg, Avi Yagil Tags: Research Article Source Type: research
Evaluation of Bio-Rad ® discs for antimicrobial susceptibility testing by disc diffusion and the ADAGIO™ system for the automatic reading and interpretation of results
In this study, the performance of both Bio-Rad ® antibiotic discs (as compared with Oxoid® discs) and the ADAGIO™ automated system for the reading of disc diffusion test results was evaluated with American Type Culture Collection (ATCC) quality control (QC) and wild strains of bacteria. Inhibition zones of both disc brands were read manually and through use of the ADAGIO™ system. Categorized interpretation of the results for each strain and antibiotic combination was summarized according to the Clinical Laboratory Standards Institute MS-100 (2017 update) manual and ADAGIO™ readings. Eight ATCC QC ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - November 12, 2019 Category: Microbiology Source Type: research
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma [Medical Sciences]
Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, however, has not been reported for treating pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest malignancies worldwide. By uncovering the elevated PGAM1 expressions were statistically related... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 12, 2019 Category: Science Authors: Chen-Lei Wen, Ke Huang, Lu-Lu Jiang, Xiong-Xiong Lu, Yu-Ting Dai, Min-Min Shi, Xiao-Mei Tang, Qing-Bing Wang, Xiao-Dan Zhang, Peng-Hui Wang, Hui-Ti Li, Xiao-Xue Ruan, Li-Wen Wang, Xin-Jing Wang, Qian Wang, Wei Lu, Xiao-Qiang Xiang, Xun Sun, Yan-Hui Xu, Lu Tags: Biological Sciences Source Type: research
Inference and uncertainty quantification for noisy matrix completion [Applied Mathematics]
Noisy matrix completion aims at estimating a low-rank matrix given only partial and corrupted entries. Despite remarkable progress in designing efficient estimation algorithms, it remains largely unclear how to assess the uncertainty of the obtained estimates and how to perform efficient statistical inference on the unknown matrix (e.g., constructing a... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 12, 2019 Category: Science Authors: Yuxin Chen, Jianqing Fan, Cong Ma, Yuling Yan Tags: Physical Sciences Source Type: research
Recurrent functional misinterpretation of RNA-seq data caused by sample-specific gene length bias
by Shir Mandelboum, Zohar Manber, Orna Elroy-Stein, Ran Elkon Data normalization is a critical step in RNA sequencing (RNA-seq) analysis, aiming to remove systematic effects from the data to ensure that technical biases have minimal impact on the results. Analyzing numerous RNA-seq datasets, we detected a prevalent sample-specific length effect that leads to a strong association between gene length and fold-change estimates between samples. This stochastic sample-specific effect is not corrected by common normalization methods, including reads per kilobase of transcript length per million reads (RPKM), Trimmed Mean of M v...
Source: PLoS Biology: Archived Table of Contents - November 12, 2019 Category: Biology Authors: Shir Mandelboum Source Type: research
IJERPH, Vol. 16, Pages 4441: Association between the Type of Diabetes Treatment and Depressive Symptoms among Patients with Diabetes: A Cross-Sectional Study of Korea Community Health Surveys Data, 2011 –2016
This study used data from the 2011&ndash;2016 Korea Community Health Survey, which included responses from 50,774 male and 48,978 female participants with diabetes who were receiving pharmacological treatments. Patients aged &ge;30 years were included. Logistic regression analysis was conducted to examine the significance of the association. Male participants treated with insulin injection were more likely to experience depressive symptoms than those taking oral hypoglycemic (oral agents) only (odds ratio (OR) = 1.27; 95% confidence interval (CI): 1.04&ndash;1.56). Male patients treated with both or...
Source: International Journal of Environmental Research and Public Health - November 12, 2019 Category: Environmental Health Authors: Lee Jang Lee Oh Park Tags: Article Source Type: research
The Effect of Advance Care Planning on Heart Failure: a Systematic Review and Meta-analysis
ConclusionsACP improved quality of life, patient satisfaction with end-of-life care and the quality of end-of-life communication for patients suffering from heart failure and could be most effective when the right timing, follow-up and involvement of important others was considered. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - November 12, 2019 Category: Internal Medicine Source Type: research
Efficacy of Antidepressants in the Treatment of Obstructive Sleep Apnea Compared to Placebo. A Systematic Review with Meta-Analyses.
AbstractPurposeTo establish the efficacy of oral antidepressants compared to placebo in improving obstructive sleep apnea (OSA) as measured on a polysomnography study. Secondary outcomes included self-reported sleepiness.MethodsAuthors identified prospective randomized placebo-controlled studies from MEDLINE through PubMed, Web of Science, the Cochrane Library and EMBASE up to February 2019 in English language. Antidepressants included tricyclic antidepressants (TCA), tetracyclic antidepressants (TeCA), selective serotonin reuptake inhibitors (SSRI), and serotonin receptor modulators (SRM). Studies were assessed for inclus...
Source: Sleep and Breathing - November 12, 2019 Category: Respiratory Medicine Source Type: research
Physiotherapy rehabilitation for osteoporotic vertebral fracture —a randomised controlled trial and economic evaluation (PROVE trial)
ConclusionsAdherence was problematic. Benefits at 4 months did not persist and at 12 months, we found no significant differences between treatments. There is inadequate evidence a short physiotherapy intervention of either manual therapy or home exercise provides long-term benefits, but arguably short-term benefits are valuable.Trial registrationISRCTN 49117867. (Source: Osteoporosis International)
Source: Osteoporosis International - November 12, 2019 Category: Orthopaedics Source Type: research
Consequences of altering statistical significance threshold in orthopaedic science
Metascience or “research-on-research” has become an integral part of modern clinical science. (Source: Injury)
Source: Injury - November 12, 2019 Category: Orthopaedics Authors: Aleksi Reito Source Type: research
A Framework for Automatic Morphological Feature Extraction and Analysis of Abdominal Organs in MRI Volumes
AbstractThe accurate 3D reconstruction of organs from radiological scans is an essential tool in computer-aided diagnosis (CADx) and plays a critical role in clinical, biomedical and forensic science research. The structure and shape of the organ, combined with morphological measurements such as volume and curvature, can provide significant guidance towards establishing progression or severity of a condition, and thus support improved diagnosis and therapy planning. Furthermore, the classification and stratification of organ abnormalities aim to explore and investigate organ deformations following injury, trauma and illnes...
Source: Journal of Medical Systems - November 12, 2019 Category: Information Technology Source Type: research
Risk prediction for 30-day mortality among patients with Clostridium difficile infections: a retrospective cohort study
ConclusionsOur model that included novel biomarkers of BUN-to-SCr ratio and glucose have a higher predictive performance of 30-day mortality and prolonged ICU stay following CDI than do the guidelines. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - November 12, 2019 Category: Infectious Diseases Source Type: research
Impact of socioeconomic deprivation on short-term outcomes and long-term overall survival after colorectal resection for cancer
AbstractPurposeThe aim of this study was to assess the effects of socioeconomic deprivation on short-term outcomes and long-term overall survival following major resection of colorectal cancer (CRC) at a tertiary hospital in England.MethodThis was an observational cohort study of patients undergoing resection for colorectal cancer from January 2010 to December 2017. Deprivation was classified into quintiles using the English Indices of Multiple Deprivation 2010. Primary outcome was overall complications (Clavien-Dindo grades 1 to 5). Secondary outcomes were the major complications (Clavien-Dindo 3 to 5), length of hospital...
Source: International Journal of Colorectal Disease - November 12, 2019 Category: Gastroenterology Source Type: research
REFLECT —a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset
ConclusionsThe efficacy and safety of LEN in the Japanese population were similar to those in the overall population of REFLECT. With manageable adverse events, LEN is a new treatment option for Japanese patients with uHCC.Trial registration IDClinicalTrials.gov. No. NCT01761266. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 12, 2019 Category: Gastroenterology Source Type: research
Stapes stabilizing cartilage graft
ConclusionsBetter hearing outcomes were obtained with SSCG than with PPORP. SSCG can be used as an alternative hearing reconstruction technique in cases of type 3 tympanoplasty. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - November 12, 2019 Category: ENT & OMF Source Type: research
Appropriateness of insulin commencement and adequacy of glycemic control among ambulatory patients with type 2 diabetes in Ethiopia
ConclusionsAbout two third of insulin commencements were inappropriate and majority of patients could not stay on optimal glycemic control. Addition of second antidiabetic medication and living in urban areas were found to be associated with poor glycemic control.Impact of findings on practice statements• Initiation of insulin before optimization of oral agents increase cost of care.• Proper titration of the first oral agent is important prior to adding other antidiabetic agents.• Emphasis should be given to improve glycemic control, and hence halt subsequent complications. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - November 12, 2019 Category: Endocrinology Source Type: research
Turkish paediatric dentists ’ knowledge, experiences and attitudes regarding child physical abuse
ObjectivesNumerous studies have shown that the education of health professionals is essential to effectively respond to child abuse. The present study aimed to evaluate Turkish paediatric dentists' knowledge, experiences and attitudes regarding child physical abuse.Materials and methodsAn electronic questionnaire was e ‐mailed to 518 paediatric dentists. Participants’ knowledge of diagnostic indicators of child physical abuse, and their past experiences, attitudes and self‐assessment of educational needs were evaluated.ResultsThe response rate was 40.9% (n = 212). Participants who completed their underg...
Source: International Dental Journal - November 12, 2019 Category: Dentistry Authors: Nermin Özgür, Elif Ballıkaya, H. Cem Güngör, Atilla S. Ataç Tags: Scientific Research Report Source Type: research
Cancer burden attributable to human papillomavirus infection by sex, cancer site, age, and geographical area in China
ConclusionsThe cancer burden attributable to HPV in China is substantial. HPV vaccination and cervical screening should be prioritized. (Source: Cancer Medicine)
Source: Cancer Medicine - November 12, 2019 Category: Cancer & Oncology Authors: Rufei Duan, Youlin Qiao, Gary Clifford, Fanghui Zhao Tags: ORIGINAL RESEARCH Source Type: research
ASCO 2019: highlights in HER2-positive metastatic breast cancer
In this study a clinically meaningful prolongation of PFS by 2.2 months was observed. In addition, the time to intervention for brain metastases was prolonged in the neratinib group and the cumulative incidence of brain metastases was lower as well. On the downside a high rate of grade 2 and 3 diarrhoea was observed. (Source: Memo - Magazine of European Medical Oncology)
Source: Memo - Magazine of European Medical Oncology - November 12, 2019 Category: Cancer & Oncology Source Type: research
Surgery with Radical Intent: Is There an Indication for G3 Neuroendocrine Neoplasms?
ConclusionsSurgery with radical intent might represent a valid option for GEP-NEN G3 patients with locoregional disease, especially with Ki67 value ≤ 55%. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 12, 2019 Category: Cancer & Oncology Source Type: research
Association of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A With Clinical Features of Youth-Onset Schizophrenia
We investigated the associations of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A with youth-onset schizophrenia in the Russian population in a case–control study, and the role of the genotype in the severity of clinical features. The association between rs7322347 and schizophrenia (p = 0.0001) is described for the first time. Furthermore, we found a link with rs6280 and rs4680 in females (p = 0.001 and p = 0.02 respectively) and with rs7322347 in males (p = 0.002). Clinical symptoms were assessed on three scales: the Clinician-Rated Dimensions of Psychosis Symptom Severity scale, Positive and Negative Syndrome Scale...
Source: Frontiers in Psychiatry - November 12, 2019 Category: Psychiatry Source Type: research
Bilateral reversed palmaris longus muscle: a case report and systematic literature review
ConclusionVariations in palmaris longus are purported to be as a result of phylogenetic regression. Clinically, patients with this variant may present with pain or swelling of the distal forearm, often as a result of intense physical exertion related to occupation or sport. Clinicians should be aware of this muscle variant as its presence could lead to confusion during tendon allograft harvesting procedures in reconstructive and tendon grafting surgery. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - November 12, 2019 Category: Anatomy Source Type: research
Randomized placebo-controlled study of the memory effects of pomegranate juice in middle-aged and older adults.
CONCLUSIONS: Daily consumption of pomegranate juice may stabilize the ability to learn visual information over a 12-mo period. This trial was registered at clinicaltrials.gov as NCT02093130. PMID: 31711104 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - November 12, 2019 Category: Nutrition Authors: Siddarth P, Li Z, Miller KJ, Ercoli LM, Merril DA, Henning SM, Heber D, Small GW Tags: Am J Clin Nutr Source Type: research
& #8220;My life is spoiled because of him & #8230; & #8221; A qualitative study of human immunodeficiency virus disclosure and male involvement in prevention of mother-to-child transmission program
Conclusions: DPM suggestions from the present study can be used to facilitate a goal-directed process that allows parents/PLWHA to selectively disclose their HIV status to family members and acquaintances for obtaining maximum support to eliminate newborn HIV infections while minimizing distress, stigma, and discrimination. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Anjali Modi Jayendrakumar K Kosambiya Sangita Trivedi Vipul P Chaudhari Alap Mehta Kristen J Wells Source Type: research
Prevalence of primary infertility and its associated risk factors in urban population of central India: A community-based cross-sectional study
Conclusion: The prevalence rate of primary infertility in urban population of Central India was lower than reported trends of infertility from developing countries. Sound knowledge about various factors related to infertility can help health-care providers and policymakers to design and implement various policies. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Ashwini Katole Ajeet V Saoji Source Type: research
Domestic violence and its determinants among 15 & #8211;49-year-old women in a rural block in South India
Conclusions: The high prevalence of domestic violence in our community needs to be addressed as it has tacit implications on socioeconomic well-being, physical and mental health of a woman, her family, and thereby, society as a whole. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Ananth Ram Catherine Priscilla Victor Hana Christy Sneha Hembrom Anne George Cherian Venkata Raghava Mohan Source Type: research
Health-care waste management in public sector of Tripura, North-East India: An observational study
Conclusion: HCWM scenario including knowledge of health-care workers in Tripura is lacking. Installing proper waste management facilities, raising technical qualification at recruitment and in-service training may improve the situation. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Arjun Saha Himadri Bhattacharjya Source Type: research
Effectiveness of interventional reproductive and sexual health education among school going adolescent girls in rural area
Conclusions: Age- and sex-appropriate health education programs can facilitate the development of healthy reproductive and sexual behavior patterns among adolescents through the enhancement of knowledge and development of right attitude. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Rutuja M Phulambrikar Anup Lahanubhau Kharde Varsha N Mahavarakar Deepak B Phalke Vaishali D Phalke Source Type: research
IJERPH, Vol. 16, Pages 4433: Influence of Electronic Cigarettes on Selected Antibacterial Properties of Saliva
Conclusion: Saliva of e-cigarette users showed changes of antibacterial properties in comparison to the control group and traditional cigarette smokers. Further longitudinal studies on larger study groups should be conducted in order to assess the effect of observed changes in the antibacterial properties of saliva on oral health. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - November 12, 2019 Category: Environmental Health Authors: Dominika Cicho ńska Aida Kusiak Barbara Kocha ńska Jolanta Ochoci ńska Dariusz Świetlik Tags: Article Source Type: research
An epidemiological study on the assessment of cardiovascular health status among adults in an urban area of Teliamura municipality area, Khowai, Tripura
Conclusion: Middle age group population were worst affected by high blood pressure, high blood sugar, poor body mass index, and poor level of cholesterol. Healthy lifestyle measures might reduce the burden of CVD which could be evaluated in future research. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Kaushik Nag Nabarun Karmakar Bivek Ghosh Anjan Datta Source Type: research
Ethnotribal growth differences among schoolchildren in a Northwestern Maharashtra district: An analytical cross-sectional study
Conclusions: ST students showed a significant growth disadvantage against general and other backward classes categories, although no intertribal anthropometry differences were observed. (Source: Indian Journal of Community Medicine)
Source: Indian Journal of Community Medicine - November 12, 2019 Category: International Medicine & Public Health Authors: Shyam Ashtekar Manasi Shekhar Padhyegurjar Jagdish Powar Shekhar Bhikaji Padhyegurjar Source Type: research
RNA-Seq Perspectives to Improve Clinical Diagnosis
In recent years, high-throughput next-generation sequencing technology has allowed a rapid increase in diagnostic capacity and precision through different bioinformatics processing algorithms, tools, and pipelines. The identification, annotation, and classification of sequence variants within different target regions are now considered a gold standard in clinical genetic diagnosis. However, this procedure lacks the ability to link regulatory events such as differential splicing to diseases. RNA-seq is necessary in clinical routine in order to interpret and detect among others splicing events and splicing variants, as it wo...
Source: Frontiers in Genetics - November 12, 2019 Category: Genetics & Stem Cells Source Type: research
Genes, Vol. 10, Pages 923: Proteomics Recapitulates Ovarian Proteins Relevant to Puberty and Fertility in Brahman Heifers (Bos indicus L.)
In conclusion, the DA proteins and their pathways were related to ovarian activity in Bos indicus cattle. The genes that code for these proteins may explain some known QTLs and could be targeted in future genetic studies. (Source: Genes)
Source: Genes - November 12, 2019 Category: Genetics & Stem Cells Authors: Muhammad S. Tahir Loan T. Nguyen Benjamin L. Schulz Gry A. Boe-Hansen Milton G. Thomas Stephen S. Moore Li Yieng Lau Marina R. S. Fortes Tags: Article Source Type: research
Genes, Vol. 10, Pages 922: A Weighted Genomic Relationship Matrix Based on Fixation Index (FST) Prioritized SNPs for Genomic Selection
In this study, relative weights based on FST scores were developed and incorporated into the calculation of G and their impact on the estimation of variance components and accuracy was assessed. The results showed that prioritizing SNPs based on their FST scores resulted in an increase in the genetic similarity between training and validation animals and improved the accuracy of GS by more than 5%. (Source: Genes)
Source: Genes - November 12, 2019 Category: Genetics & Stem Cells Authors: Ling-Yun Chang Sajjad Toghiani El Hamidi Hay Samuel E. Aggrey Romdhane Rekaya Tags: Article Source Type: research
IJERPH, Vol. 16, Pages 4423: Designing Urban Green Spaces for Older Adults in Asian Cities
This study conducted interviews using a questionnaire with a sample size of 326 participants in the cities of Hong Kong (China) and Tainan (Taiwan region). The inter-relationships among the design of UGSs (e.g., spatial distribution and accessibility, characteristics of plants and UGSs), older adults&rsquo; perceptions on safety and aesthetics quality of UGSs, and their self-reported health conditions (assessed by the self-reported SF-12v2 Health Survey) were investigated with bivariate Spearman rank correlation tests. The results indicate that the duration of visits to UGSs was positively associated with mental he...
Source: International Journal of Environmental Research and Public Health - November 12, 2019 Category: Environmental Health Authors: Zheng Tan Kevin Ka-Lun Lau Adam Charles Roberts Stessa Tzu-Yuan Chao Edward Ng Tags: Article Source Type: research
Gastric Histopathologic Findings in South Italian Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: Is Histopathologic Examination of All Resected Gastric Specimens Necessary?
ConclusionHistopathologic examination of LSG specimens may not be routinely needed and can be performed on selected patients. While we recommend routine preoperative UGIE in all LSG-treated patients, we suggest that histopathologic assessment of the LSG specimens should be mandatory when UGIE biopsies demonstrate HP infection and/or premalignant lesions, in all patients older than 42 years, and in cases of intraoperative detection of incidental tumours or suspicious lesions. (Source: Obesity Surgery)
Source: Obesity Surgery - November 12, 2019 Category: Surgery Source Type: research
Role of positron emission tomography in the assessment of disease burden and risk of relapse in patients affected by giant cell arteritis
In this study, we aimed to investigate its potential prognostic value in the stratification of relapse risk. We retrospectively revised all the clinical records of patients who received a diagnosis of GCA at an immuno-rheumatology clinic of a University Hospital along 6 years and who underwent to a PET-CT examination at diagnosis. Clinical, laboratory, and imaging data were collected. Relapses were recorded. The study population included 19 patients (10 females, 52.6%; median age 74.0 [65.5 –76.0] years), 12 with typical cranial GCA (63%) and 7 (37%) with LV-GCA. Based on PET findings, a diagnosis of aortitis was mad...
Source: Clinical Rheumatology - November 12, 2019 Category: Rheumatology Source Type: research
Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study
ConclusionSimple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers. (Source: Neuroradiology)
Source: Neuroradiology - November 12, 2019 Category: Radiology Source Type: research
Correlation Between Diabetic Cognitive Impairment and Diabetic Retinopathy in Patients With T2DM by 1H-MRS
Objective: To explore the correlation between diabetic cognitive impairment (DCI) and diabetic retinopathy (DR) through examining the cognitive function and the metabolism of the cerebrum in Type 2 diabetes mellitus (T2DM) by 1H-MRS.Methods: Fifty-three patients with T2DM were enrolled for this study. According to the fundus examination, the patients were divided into the DR group (n = 26) and the T2DM without DR group (T2DM group, n = 27). Thirty healthy adults were selected as a control group (HC group, n = 30). Cognitive function was measured by Montreal Cognitive Assessment (MoCA). The peak areas of N-acetylaspartate (...
Source: Frontiers in Neurology - November 12, 2019 Category: Neurology Source Type: research