Comparison of maternal venous blood metabolomics collected as dried blood spots, dried blood microsamplers, and plasma for integrative environmental health research
Environ Int. 2024 Apr 16;187:108663. doi: 10.1016/j.envint.2024.108663. Online ahead of print.ABSTRACTUse of capillary blood devices for exposome research can deepen our understanding of the intricate relationship between environment and health, and open up new avenues for preventive and personalized medicine, particularly for vulnerable populations. While the potential of these whole blood devices to accurately measure chemicals and metabolites has been demonstrated, how untargeted metabolomics data from these samplers can be integrated with previous and ongoing environmental health studies that have used conventional blood collection approaches is not yet clear. Therefore, we performed a comprehensive comparison between relative-quantitative metabolite profiles measured in venous blood collected with dried whole blood microsamplers (DBM), dried whole blood spots (DBS), and plasma from 54 mothers in an ethnically diverse population. We determined that a majority of the 309 chemicals and metabolites showed similar median intensity rank, moderate correlation, and moderate agreement between participant-quantiled intraclass correlation coefficients (ICCs) for pair-wise comparisons among the three biomatrices. In particular, whole blood sample types, DBM and DBS, were in highest agreement across metabolite comparison metrics, followed by metabolites measured in DBM and plasma, and then metabolites measured in DBS and plasma. We provide descriptive characteristics and measurement ...
Source: Environment International - Category: Environmental Health Authors: Lauren Petrick Haibin Guan Grier P Page Georgia Dolios Megan M Niedzwiecki Robert O Wright Rosalind J Wright program collaborators for Environmental Influences on Child Health Outcomes Source Type: research
More News: Chemistry | Children | Databases & Libraries | Environmental Health | Georgia Health | Statistics | Study