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Hypoxia-Induced Activation of JAK/STAT3 Signaling Pathway Promotes Trophoblast Cell Viability and Angiogenesis in Preeclampsia.
CONCLUSIONS These findings indicate that hypoxic preconditioning may contribute to activation of the JAK/STAT3 signaling pathway, thus promoting trophoblast cell viability and angiogenesis in PE. PMID: 29030540 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 18, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Whole-Body Vibration Combined with Treadmill Training Improves Walking Performance in Post-Stroke Patients: A Randomized Controlled Trial.
Authors: Choi W, Han D, Kim J, Lee S Abstract BACKGROUND Stroke is characterized by an asymmetrical gait pattern that causes poor stability and reduces overall activity levels. The aim of this study was to investigate the effect of whole-body vibration combined with treadmill training (WBV-TT) on walking performance in patients with chronic stroke. MATERIAL AND METHODS Thirty ambulatory chronic stroke patients were randomly allocated to the WBV-TT group or the treadmill training (TT) group. The participants in the WBV-TT group performed 6 types of exercises on a vibrating platform for 4.5 minutes and then walked on...
Source: Medical Science Monitor - October 18, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Correlation Between Vertebral Endplate Change and Lumbar Disc Degeneration.
CONCLUSIONS Endplate angle and lumbar disc degeneration are positively correlated. The endplates and endplate signal changes can reflect the degree of disc degeneration and Modic changes can reflect the rate of clinical lumbar disc degeneration degree. PMID: 29032381 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 18, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Angiotensin-Converting Enzyme Gene Deletion Polymorphism is Associated with Lymph Node Metastasis in Colorectal Cancer Patients in a Chinese Population.
CONCLUSIONS DD genotype and D allele of ACE gene I/D polymorphism might increase the risk of LNM in CRC patients. PMID: 29032382 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 18, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Symptomatology Patterns in Children with Allergic Rhinitis.
CONCLUSIONS Our results suggest that allergen sensitivity may be correlated with symptomatology patterns among children who have allergic rhinitis. PMID: 29033449 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 18, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Investigation of Association Between Borderline Pancreatic Head Cancer and Glucose Uptake by Using Positron-Emission Tomographic Studies.
CONCLUSIONS Our PET protocol appears to be an indicator for estimation of recurrence of pancreatic head cancer and is as an indispensable asset to oncologists. PMID: 29036034 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 18, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Aberrant Promoter Methylation of Protocadherin8 (PCDH8) in Serum is a Potential Prognostic Marker for Low Gleason Score Prostate Cancer.
Authors: Lin YL, Li YL, Ma JG Abstract BACKGROUND PCDH8 is a newly-discovered suppressor gene that is frequently inactivated by aberrant methylation in several human cancers, including prostate cancer. The identification of PCDH8 methylation can be used as a potential predictive biomarker. Prostate cancer patients with high Gleason score are considered as being at high risk for tumor recurrence and progression, and adjuvant therapy is often routinely performed in clinical practice. In the present study, we did not measure the methylation of PCDH8 in these patients. The main purpose of the present study was to evalu...
Source: Medical Science Monitor - October 16, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Imaging Factors that Distinguish Between Patients with Asymptomatic and Symptomatic Cervical Spondylotic Myelopathy with Mild to Moderate Cervical Spinal Cord Compression.
Authors: Cao JM, Zhang JT, Yang DL, Yang YP, Xia HH, Yang L Abstract BACKGROUND Not all patients with spinal cord compression due to cervical spondylotic myelopathy (CSM) have clinical symptoms and signs. The aim of this study was to investigate and compare the imaging findings in asymptomatic and symptomatic patients with CSM with mild to moderate cervical spinal cord compression. MATERIAL AND METHODS A retrospective clinical study included 68 patients. Group A (n=30) had no symptoms and signs; group B (n=38) had symptoms and signs of cervical myelopathy. The age, sex, body mass index (BMI), history of steroid tre...
Source: Medical Science Monitor - October 16, 2017 Category: Research Tags: Med Sci Monit Source Type: research

The Lethal Spanish Influenza Pandemic in Poland.
Authors: Grabowski ML, Kosińska B, Knap JP, Brydak LB Abstract The Spanish influenza pandemic in the years 1918-1920 was the largest and most tragic pandemic of infectious disease in human history. Deciphering the structure of the virus (including the determination of complete genome sequence) of this pandemic and the phylogenetic analysis and explanation of its virulence became possible thanks to molecular genetic analysis of the virus isolated from the fixed and frozen lung tissue of influenza victims who died in 1918 and were buried frozen in Alaska and Spitsbergen. Epidemiological data from the course of this ...
Source: Medical Science Monitor - October 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

MiR-150 Inhibits Cell Growth In Vitro and In Vivo by Restraining the RAB11A/WNT/ β-Catenin Pathway in Thyroid Cancer.
CONCLUSIONS miR-150 may function as a suppressor gene in TC cells by inhibiting the RAB11A/WNT/β-catenin pathway. PMID: 29023429 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Clinical and Prognostic Significance of Pathological and Inflammatory Markers in Mucinous Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy and Curative Surgery.
CONCLUSIONS Pretreatment lymphocyte-to-monocyte ratio is a useful prognostic marker of OS in patients with mucinous rectal carcinoma treated with neoadjuvant chemoradiotherapy and curative surgery. PMID: 28988257 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.
This study was designed to evaluate the function of olig2 in cuprizone-induced schizophrenia-like symptoms in a mouse model, and to assess the related mechanisms. MATERIAL AND METHODS The schizophrenia-like symptoms were modeled by administration of cuprizone in mice. Open-field and elevated-plus maze tests were applied to detect behavioral changes. Adenovirus encoding olig2 siRNA was designed to silence olig2 expression. Real-time PCR and western blotting were applied to detect myelin basic protein (MBP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), glial fibrillary acidic protein (GFAP) and olig2 expressions. R...
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Delayed Diagnosis is Associated with Early and Emergency Need for First Crohn's Disease-Related Intestinal Surgery.
CONCLUSIONS Delayed diagnosis is associated with early and emergency need for the first Crohn's disease-related intestinal surgery. PMID: 28991890 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

External Validation of Survival-Predicting Models for Acute Myocardial Infarction with Extracorporeal Cardiopulmonary Resuscitation in a Chinese Single-Center Cohort.
CONCLUSIONS The ECPR and SHOCK models possess important abilities to predict intrahospital outcomes of AMI patients treated with E-CPR. PMID: 28993606 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

A Modified Laminoplasty Technique to Treat Cervical Myelopathy Secondary to Ossification of the Posterior Longitudinal Ligament (OPLL).
CONCLUSIONS Modified laminoplasty may be considered a safe and effective strategy for patients that have demonstrated close-base OPLL with an occupying ratio of more than 60% and who cannot endure the trauma caused by the combined anterior-posterior approach due to medical disease. PMID: 29016554 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy.
CONCLUSIONS In model of CKD - 5/6 nephrectomy, SDR proved to be sensitive and WR resistant to development of CKD. The intrarenal activity of the nitric oxide pathway was the factor that differentiated both strains. This mechanism may be responsible for insensitivity of WR to development of renal failure in this model of CKD. PMID: 29018182 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Transthoracic Balloon Pulmonary Valvuloplasty for Treatment of Congenial Pulmonary Atresia Patients with Intact Ventricular Septum.
CONCLUSIONS The application of transthoracic balloon pulmonary valvuloplasty for the treatment of PA/IVS is minimally invasive and safe, which has great significance for improving the curative effect for this condition and reducing operation mortality. PMID: 29019966 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Predictive Value of Circulating Tumor Cells for Evaluating Short- and Long-Term Efficacy of Chemotherapy for Breast Cancer.
Authors: Ma S, Ling F, Gui A, Chen S, Sun Y, Li Z Abstract BACKGROUND The present study investigated the role of circulating tumor cells (CTCs) counts in predicting the short- and long-term efficacy of chemotherapy for breast cancer (BC). MATERIAL AND METHODS Peripheral venous blood was extracted from 187 BC patients. CTCs were measured by flow cytometry. Spearman's correlation analysis was performed to examine the correlation between the efficacy of chemotherapy and CTC counts. A receiver operating characteristic (ROC) curve was plotted to estimate the predictive value of CTC counts. The Kaplan-Meier method was em...
Source: Medical Science Monitor - October 9, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.
CONCLUSIONS [color=black]Downregulation of cohesin loading factor NIPBL arrested breast cancer cells in vitro in the G0/G1 phase of the cell cycle and induced apoptosis and autophagy. [/color]. PMID: 28987049 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 9, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Raf Kinase Inhibitor Protein (RKIP) Inhibits Tumor Necrosis Factor- α (TNF-α) Induced Adhesion Molecules Expression in Vascular Smooth Muscle Bells by Suppressing (Nuclear Transcription Factor-κB (NF-kappaB) Pathway.
CONCLUSIONS Taken together, these results suggested that RKIP may inhibit the TNF-α-induced expression of adhesion molecules in MOVACs through inactivation of the NF-kappaB pathway. PMID: 28983072 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 8, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of lncRNA X Inactive Specific Transcript (XIST) Suppresses Cell Proliferation and Enhances Radiosensitivity by Upregulating mir-29c in Nasopharyngeal Carcinoma Cells.
CONCLUSIONS XIST knockdown suppressed cell proliferation and enhanced radiosensitivity of NPC cells by upregulating miR-29c, providing a novel therapeutic target to improve radiotherapy efficiency for patients with NPC. PMID: 28985197 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 8, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Fibronectin-Coated Micro-Grooved Titanium Surface on Alignment, Adhesion, and Proliferation of Human Gingival Fibroblasts.
Authors: Jian X, Huang W, Wu D, You D, Lin Z, Chen J Abstract BACKGROUND Surface characters of culture plates affect cellular behaviors such as cellular alignment and elongation. Microgrooves guide the cell growth along the grooves and spread. The aim of this study was to observe the effect of fibronectin (FN)-coated micro-grooved titanium plates on the alignment, spread, adhesion, and proliferation of human gingival fibroblasts (HGFs). MATERIAL AND METHODS Micro-grooved titanium plates were fabricated, and FN was immobilized onto the micro-grooved surfaces using silanization. HGFs were cultured on the smoothed or ...
Source: Medical Science Monitor - October 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Essential Oil from Fructus Alpiniae Zerumbet Protects Human Umbilical Vein Endothelial Cells In Vitro from Injury Induced by High Glucose Levels by Suppressing Nuclear Transcription Factor-Kappa B Signaling.
CONCLUSIONS The findings of this in vitro study showed that treatment of HUVECs with EOFAZ had a protective role against the effects of high glucose levels via the NF-κB signaling pathway. PMID: 28976943 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Expression of the miR-148/152 Family in Acute Myeloid Leukemia and its Clinical Significance.
Authors: Wang XX, Zhang R, Li Y Abstract BACKGROUND MicroRNAs (miRNAs) play an important role in the development and progression of acute myeloid leukemia (AML). The miR-148/152 family has been reported to be express differently in various kinds of tumors. We investigated the expression level of the miR-148/152 family in AML patients and their clinical significance. MATERIAL AND METHODS Expression levels of the miR-148/152 family in 80 patients with newly diagnosed AML and 20 healthy participants were analyzed by qRT-PCR. We also evaluated the relationship between the expression levels of the miR-148/152 family and...
Source: Medical Science Monitor - October 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Ubiquitin Associated Protein 2-Like (UBAP2L) Overexpression in Patients with Hepatocellular Carcinoma and its Clinical Significance.
CONCLUSIONS UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis. UBAP2L could be a new potential therapeutic target for HCC in the future. PMID: 28981479 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Value of Plasma Long Noncoding RNA ANRIL for In-Stent Restenosis.
This study aimed to investigate the association between plasma ANRIL expression and ISR. MATERIAL AND METHODS A total of 444 patients were included in this research. Serial coronary angiography was performed at baseline (before and after intervention) and within 36 months' follow-up. ISR was defined as>50% diameter stenosis at follow-up. ANRIL expression was quantified using reverse transcription-PCR. An area under the ROC curve (auROC) was generated to assess the diagnostic values of ANRIL. Logistic regression models were used to assess the independent risk factors for ISR. RESULTS Plasma ANRIL expression was significa...
Source: Medical Science Monitor - October 5, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Role of Paeonol in an Astrocyte Model of Parkinson's Disease.
CONCLUSIONS The present study found that paeonol protected cells from apoptosis by repressing the activation of the JNK/ERK related signalling pathway induced by MPP+ in astrocytes. We propose that paeonol is a neuroprotective agent for the treatment of PD patients, with great promise in the future. PMID: 28972959 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 5, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of MIh Scoring System in Diagnosis of Obstructive Sleep Apnea Syndrome.
The objective of the present study was to investigate whether the analysis of magnesium (Mg), high-sensitivity C-reactive protein (hsCRP), and ischemia-modified albumin (IMA) concentrations can be used as a non-invasive and convenient method for diagnosing obstructive sleep apnea syndrome (OSAS). MATERIAL AND METHODS After polysomnography, venous blood was collected from 33 patients with OSAS and 30 control individuals. Serum levels of Mg, hsCRP, and IMA were investigated. The relationship between these factors and apnea-hypopnea index (AHI) was analyzed using the Pearson correlation coefficient. The role of the factors wa...
Source: Medical Science Monitor - October 3, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Nano-Hydroxyapatite-Derived Drug and Gene Co-Delivery System for Anti-Angiogenesis Therapy of Breast Cancer.
CONCLUSIONS p53/CD/NHAP might be a candidate carrier for efficient anti-angiogenesis therapy of breast cancer. PMID: 28968380 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 3, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Bedside Percutaneous Dilatational Tracheostomy by Griggs Technique: A Single-Center Experience.
CONCLUSIONS Tracheostomy offers advantages in terms of improving patient comfort, facilitating weaning of patients from the respirator, and providing clearance of pulmonary secretions by reducing pulmonary dead-spaces. PDT is a simple and reliable procedure with lower complication rates. Its advantages include implementation at bedside, with a shortened procedure duration and accelerated wound healing. PMID: 28963447 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

MicroRNA-495 Inhibits New Bone Regeneration via Targeting High Mobility Group AT-Hook 2 (HMGA2).
CONCLUSIONS MiR-495 inhibits new bone regeneration via targeting high mobility group AT-Hook 2 (HMGA2). We propose that targeting miR-495 may be a promising therapeutic approach for bone regeneration. PMID: 28963864 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Baricity of Bupivacaine on Median Effective Doses for Motor Block.
CONCLUSIONS The ED50 for motor block was significantly decreased using hyperbaric bupivacaine intrathecally compared with plain bupivacaine, and the baricity of bupivacaine obviously affected the ED50 for the motor block. PMID: 28965122 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Identification of miRNA-mRNA Network Associated with Acute Myeloid Leukemia Survival.
CONCLUSIONS The miRNA hsa-mir-425 was identified as the top risk factor miRNA of AML survival and CD44 was identified as one of the top three risk factor target-genes associated with AML survival. Both hsa-mir-425 and CD44 may play key roles in progression and development of AML through calcium signaling pathway and natural killer cell mediated cytotoxicity. PMID: 28965123 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Hypoxic Preconditioning Enhances Biological Function of Endothelial Progenitor Cells via Notch-Jagged1 Signaling Pathway.
CONCLUSIONS Our results suggest the Notch-Jagged1 pathway enhances EPCs proliferation and secretion ability during hypoxic preconditioning. PMID: 28959004 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 1, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Non-Invasive Approaches to Epigenetic-Based Sperm Selection.
Authors: Štiavnická M, Abril-Parreño L, Nevoral J, Králíčková M, García-Álvarez O Abstract Since sperm size and form do not necessarily provide information on internal sperm structures, novel sperm markers need to be found in order to conduct assisted reproductive therapies (ART) successfully. Currently, the priority of andrologists is not only to select those sperm able to fertilize the oocyte, but also a high quality of sperm that will guarantee a healthy embryo. Evidence of this shows us the importance of studying sperm intensively on genetic and epigeneti...
Source: Medical Science Monitor - October 1, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Association of Serum Galectin-3 with the Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
The objective of this study was to examine the dynamic changes of Gal-3 in acute exacerbation and convalescence phases of COPD. MATERIAL AND METHODS Serum levels of Gal-3, high sensitivity C-reactive protein (hsCRP), and prohormone of brain natriuretic peptide (pro-BNP) were determined using multiplex enzyme-linked immunosorbent assay kits. Serum levels of Gal-3 in 44 patients with COPD were further analyzed and correlated with the parameters of lung function and the biomarkers of systemic inflammation. RESULTS The mean level of serum Gal-3 was significantly higher in acute exacerbation of COPD compared with the level in C...
Source: Medical Science Monitor - September 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Tumor-Infiltrating CD4+ Lymphocytes Predict a Favorable Survival in Patients with Operable Esophageal Squamous Cell Carcinoma.
CONCLUSIONS Our results suggested that iCD4+ lymphocytes infiltration could be a favorable indicator for prognosis in ESCC. PMID: 28949934 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Tendon Stem Cells in Chitosan/ β-Glycerophosphate/Collagen Hydrogel on Achilles Tendon Healing in a Rat Model.
CONCLUSIONS This study demonstrates that the transplantation of TSCs combined with C/GP/Co hydrogel significantly improved the histological, immunohistochemistry, and biomechanical outcomes of the regenerated tissue at 4 and 6 weeks after implantation. TSCs with C/GP/Co hydrogel is a potentially effective treatment for tendon injury. PMID: 28951538 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Expression of N-Myc Downstream-Regulated Gene 2 in Bladder Cancer and Its Potential Utility as a Urinary Diagnostic Biomarker.
CONCLUSIONS NDRG2 was decreased in patients with bladder cancer and might be involved in the progression of this malignancy. Moreover, NDRG2 could be a potential independent diagnostic biomarker for bladder cancer. PMID: 28953854 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effects of ABCDE Bundle on Hemodynamics in Patients on Mechanical Ventilation.
This study aimed to investigate the effects of ABCDE bundle on hemodynamics in patients on mechanical ventilation (MV). MATERIAL AND METHODS This study used a cross-sectional overall controlled approach in which 143 patients on mechanical ventilation were divided into 2 groups. In the pre-ABCDE bundle group (n=70), conventional sedation and analgesia strategy were used. In the post-ABCDE bundle group (n=73), ABCDE bundle was used. Changes in hemodynamics parameters and related prognostic indicators were monitored at various time points before (T0) and at 1 d (T1), 3 d (T3), 5 d (T5), and 7 d (T7) after implementation of th...
Source: Medical Science Monitor - September 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of Vinorelbine Plus Cisplatin vs. Gemcitabine Plus Cisplatin for Treatment of Metastatic Triple-Negative Breast Cancer After Failure with Anthracyclines and Taxanes.
This study aimed to compare the efficacy and safety of vinorelbine plus cisplatin (NP regimen) vs. gemcitabine plus cisplatin (GP regimen) for treatment of metastatic TNBC after failure with anthracyclines and taxanes. MATERIAL AND METHODS A total of 48 patients with metastatic TNBC that failed in anthracyclines and taxanes treatment were enrolled and randomly grouped. Patients in the NP group (n=22) were given 25 mg/m² vinorelbine on days 1 and 8 and 25 mg/m² cisplatin on days 2-4 of each 21-day cycle, while subjects in the GP group (n=26) were administered 1000 mg/m² gemcitabine on days 1 and 8 and 25 mg/m...
Source: Medical Science Monitor - September 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Aldehyde Dehydrogenase 2 (ALDH2) Glu504Lys Polymorphism Affects Collateral Circulation and Short-Term Prognosis of Acute Cerebral Infarction Patients.
CONCLUSIONS ALDH2 Glu504Lys could be a risk factor for collateral circulation and a negative predictor for short-term prognosis in acute cerebral infarction in Han Chinese. ALDH2 Glu504Lys could be a new therapeutic target for patients with acute cerebral infarction. PMID: 28939800 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Rates of Vaccination against Streptococcus Pneumoniae in Cochlear Implant Patients.
CONCLUSIONS The percentage of patients with cochlear implants who received vaccination against S. pneumoniae was low, both in children and adults, but especially in adults comparing to available reports. PMID: 28941358 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Fostering Flu Vaccination in Healthcare Workers: Forum Theatre in a University Hospital.
Authors: Corsaro A, Poscia A, de Waure C, De Meo C, Berloco F, Ricciardi W, Damiani G, Laurenti P, Group C Abstract The World Health Organization recommends flu vaccination as the most effective way to prevent the disease and its severe outcomes and has established the minimum vaccination coverage for people at risk at 75%. Even though healthcare workers (HCWs) represent a strongly recommended target group for flu vaccination campaigns, the average coverage among them is still inadequate. In flu season 2015/2016, our University Hospital tested Forum Theatre (FT) as a new participative strategy to foster HCWs engage...
Source: Medical Science Monitor - September 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Staphylococcus Aureus Induces Osteoclastogenesis via the NF- κB Signaling Pathway.
CONCLUSIONS This study demonstrated that S. aureus induces osteoclastogenesis through its cell wall compound and secretion of small soluble molecules, and the NF-κB signaling pathway plays a role in this process. PMID: 28942456 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Differences in ABCA1 R219K Polymorphisms and Serum Indexes in Alzheimer and Parkinson Diseases in Northern China.
CONCLUSIONS ABCA1 R219K R allele was the risk factor inducing abnormal serum levels of ApoA2, LDL, and TG in AD patients, and abnormal levels of serum ABCA1, HDL, IL-1b, IL-6, and TNF-α in PD patients, while ABCA1 R219K K allele was the risk factor inducing lower ABCA1 in AD patients. IL-1β, IL-6, and TNF-α were negatively correlated to MMSE in AD patients but positively correlated to H-Y in PD patients, while HDL was positively related to H-Y in PD patients. PMID: 28943632 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Nano-Hydroxyapatite/Polyetheretherketone-Coated, Sandblasted, Large-Grit, and Acid-Etched Implants on Inflammatory Cytokines and Osseointegration in a Peri-Implantitis Model in Beagle Dogs.
CONCLUSIONS Our findings demonstrate that SLA + n-HA/PEEK implants can promote osseointegration and relieve the inflammation response of peri-implantitis in beagle dogs. PMID: 28945699 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Cytokines Interleukin 4 (IL-4) and Interleukin 10 (IL-10) Gene Polymorphisms as Potential Host Susceptibility Factors in Virus-Induced Encephalitis.
This study aimed to analyze and explore the relationship between the cytokines IL-4 and IL-10 in relation to gene polymorphism and their respective effects on the susceptibility to virus-induced encephalitis. MATERIAL AND METHODS From January 2012 to June 2013, 112 patients with virus-induced encephalitis (the case group and 109 healthy individuals (the control group) were recruited for the purposes of this study. The functional variations that IL-4 and IL-10 genes exhibit were detected through the use of a function analysis and selection tool for single-nucleotide polymorphisms (FASTSNP). The genotypes of IL-4 were rs2227...
Source: Medical Science Monitor - September 23, 2017 Category: Research Tags: Med Sci Monit Source Type: research

A Risk Factor Analysis of Cognitive Impairment in Elderly Patients with Chronic Diseases in a Chinese Population.
CONCLUSIONS Our study provides evidence that cerebral infarction history, number of CD4+ cells, admission times, GDS score, and age are risk factors of CI in elderly patients with chronic diseases. PMID: 28937972 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 23, 2017 Category: Research Tags: Med Sci Monit Source Type: research

A New Method in Laparoscopic Sleeve Gastrectomy: Reverse Trendelenburg with Right Lateral Tilt Position Prior to Trocar Entry.
CONCLUSIONS PBET is an effective method which both shortens the operation time and decreases the rate of uncompleted operations. PMID: 28928358 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 22, 2017 Category: Research Tags: Med Sci Monit Source Type: research