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High CXC Chemokine Ligand 16 (CXCL16) Expression Promotes Proliferation and Metastasis of Lung Cancer via Regulating the NF- κB Pathway.
High CXC Chemokine Ligand 16 (CXCL16) Expression Promotes Proliferation and Metastasis of Lung Cancer via Regulating the NF-κB Pathway. Med Sci Monit. 2018 Jan 21;24:405-411 Authors: Liang K, Liu Y, Eer D, Liu J, Yang F, Hu K Abstract BACKGROUND CXC chemokine ligand 16 (CXCL16) is a soluble chemokine with a transmembrane domain, playing an important role in inflammatory regulation. NF-κB has a critical role in tumor progression. Recent studies focused on the effect of CXCL16 on tumor progression. However, few reports showed the influence of CXCL16 on lung cancer, especially in regulating NF...
Source: Medical Science Monitor - January 23, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM).
CONCLUSIONS These results indicate that quercetin targets and destroys breast cancer stem cells, making it a potential novel drug in the fight against cancer. PMID: 29353288 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 23, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Role of B and T Lymphocyte Attenuator in Renal Transplant Recipients with Biopsy-Proven Acute Rejection.
CONCLUSIONS The findings indicate that the BTLA/HVEM pathway does be involved in pathogenesis of acute rejection following kidney transplantation, as well as the induction of transplant tolerance. This pathway may therefore be a useful target for therapy against acute rejection after kidney transplantation. PMID: 29352109 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 21, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Neurotransmitters and Receptors Changes in Medial Nucleus of the Trapezoid Body (MNTB) of Early-Developmental Rats with Single-Side Deafness.
Authors: Dai J, Liu J, Zhou M, Wang W, Xu ZD, Wang N Abstract BACKGROUND Congenital single-side deafness (SSD) affects sound localization even after cochlear implantation (CI) in some conditions. The medial nucleus of the trapezoid body (MNTB) plays an important role in binaural benefit and sound localization, but little is known about intrinsic molecular changes in MNTB with SSD. We aimed to observe changes in MNTB in early-developmental SSD rats, including the key neurotransmitters (GABA, Gly, Glu) and major receptors (GABAa-R/GABAb-R for GABA, Gly-R for Gly, and AMPA/NMDA for Glu). MATERIAL AND METHODS The model...
Source: Medical Science Monitor - January 21, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Martrilin-3 (MATN3) Overexpression in Gastric Adenocarcinoma and its Prognostic Significance.
Authors: Wu PL, He YF, Yao HH, Hu B Abstract BACKGROUND The aim of this study was to investigate the expression level of martrilin-3 (MATN3) in patients with gastric adenocarcinoma (GAC) and to investigate the prognostic significance of MATN3. MATERIAL AND METHODS Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data were used to predict the expression and prognostic value of MATN3 mRNA in GAC patients. Seventy-six GAC patients had GAC tissue samples and paired adjacent normal tissue samples collected retrospectively to examine the MATN3 protein expression level by immunohistochemical staining. Furt...
Source: Medical Science Monitor - January 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of 1,25-Dihydroxyvitamin D3 on the Prevention of Chronic Obstructive Pulmonary Disease (COPD) in Rats Exposed to Air Pollutant Particles Less than 2.5 Micrometers in Diameter (PM2.5).
CONCLUSIONS 1,25(OH)2D3 prevented lung injury in COPD rats with or without PM2.5 exposure. Our results suggest that 1,25(OH)2D3 is useful to mitigate the injury caused by COPD. PMID: 29345249 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Gastrointestinal Bleeding on Gastrointestinal Stromal Tumor Patients: A Retrospective Cohort Study.
Authors: Huang Y, Zhao R, Cui Y, Wang Y, Xia L, Chen Y, Zhou Y, Wu X Abstract BACKGROUND The contemporary risk classification criteria of gastrointestinal stromal tumors (GISTs) may still have room to improve. The aim of our research was to analyze the impact factors for GIST patients' relapse-free survival (RFS). Furthermore, we explore whether gastrointestinal (1) bleeding will be a valuable indicator to predict GIST patients' prognosis. MATERIAL AND METHODS R0 resection GISTs patients were retrospectively enrolled during an 8-year period at West China Hospital of Sichuan University, and all patients' data were f...
Source: Medical Science Monitor - January 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population.
CONCLUSIONS None of the examined SNPs were a risk factor for the susceptibility to childhood ASD and severity of the disease in a Han Chinese population. PMID: 29348398 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Use of Different Methods of Intramedullary Nailing for Fixation of Distal Radius Fractures: A Retrospective Analysis of Clinical and Radiological Outcomes.
Authors: Çalbıyık M, Ipek D Abstract BACKGROUND We aimed to evaluate the clinical and radiologic outcomes of using Sonoma WRx versus Micronail intramedullary nailing for the fixation of distal radius fractures. MATERIAL AND METHODS A total of 68 patients with primarily extra-articular and simple intra-articular fractures of the distal radius who underwent intramedullary distal radius fixation using Sonoma WRx (n=39) or Micronail (n=29) intramedullary nails were enrolled in the study. The clinical outcome measures included the range of motion (ROM), visual analog scale (VAS), functional outcomes (patient-re...
Source: Medical Science Monitor - January 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Prevalence and Causes of Visual Impairment in Adults in Binhu District, Wuxi, China.
This study aimed to evaluate the current prevalence and causes of visual impairment among adults who were 50 years old and older in the Binhu District of Wuxi City, China. MATERIAL AND METHODS A randomized sample of stratified clusters was used to analyze individuals from 30 basic sampling units in Wuxi Binhu District. Visual impairment was defined according to World Health Organization (WHO) standards. RESULTS A total of 6725 people who were at least 50 years old participated in this study. According to WHO standards, bilateral low vision and blindness prevalence were both higher in women than in men (low vision: 6.5% vs....
Source: Medical Science Monitor - January 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

High Number of Circulating Tumor Cells Predicts Poor Survival of Cutaneous Melanoma Patients in China.
CONCLUSIONS Baseline CTC count was correlated with adverse pathological features and was predictive of survival in melanoma patients. Alteration of CTC count before and after treatment was an indicator of therapy response and prognosis. Measuring the baseline and post-treatment CTC counts is a powerful tool in monitoring melanoma progression, drug response, and survival. PMID: 29337932 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor.
This study aimed to explore the role of Cav-1 in CRC and the associated mechanisms. MATERIAL AND METHODS Fresh tissues from patients with CRC and human CRC SW480 cells were used to evaluate Cav-1 and Ki-67 expression using immunohistochemistry and Western blotting. The MTS and Transwell assays were performed to determine the effects of Cav-1 overexpression via pcDNA3.1/Cav-1 plasmid on cell proliferation and metastasis. The effect of Cav-1 on the epidermal growth factor receptor (EGFR) activation was evaluated by Western blotting. The correlation of Cav-1 expression with clinicopathological factors was statistically analyz...
Source: Medical Science Monitor - January 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Thyroid-Stimulating Hormone Levels Are Positively Associated with Insulin Resistance.
Authors: Zhu P, Liu X, Mao X Abstract BACKGROUND It has been reported that overt and mild thyroid dysfunctions are associated with insulin resistance (IR). We performed this retrospective study to evaluate the relationships between thyroid-stimulating hormone (TSH) levels within the reference range and IR. MATERIAL AND METHODS A total of 447 outpatients were enrolled in this study: 298 with type 2 diabetes mellitus and 149 nondiabetic individuals. Based on a cutoff HbA1c value of 7%, diabetic patients were additionally divided into 2 groups: a high-HbA1c group (n=240) and a low-HbA1c group (n=58). The relationships...
Source: Medical Science Monitor - January 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Proteasome Inhibitor Carbobenzoxy-L-Leucyl-L-Leucyl-L-Leucinal (MG132) Enhances Therapeutic Effect of Paclitaxel on Breast Cancer by Inhibiting Nuclear Factor (NF)- κB Signaling.
CONCLUSIONS Based on our findings, we suggest the application of MG132 in clinical practice in combination with PTX for the treatment of breast cancer. PMID: 29332931 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Carnosine (Beta-Alanyl-L-Histidine) in an Experimental Rat Model of Acute Kidney Injury Due to Septic Shock.
CONCLUSIONS Carnosine (beta-alanyl-L-histidine) has been shown to have beneficial effects in reducing AKI due to septic shock in a rat model of septicemia. PMID: 29334583 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Robot-Assisted Radical Prostatectomy Is More Beneficial for Prostate Cancer Patients: A System Review and Meta-Analysis.
CONCLUSIONS This meta-analysis demonstrates that RARP results in better overall outcomes than LRP and ORP in terms of blood loss, transfusion rate, nerve sparing, urinary continence and erectile dysfunction recovery, and suggests that RARP offers better results than LRP and ORP in treatment of prostate cancer. However, studies with larger sample sizes and long-term results are needed. PMID: 29332100 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Is Kinesio Taping to Generate Skin Convolutions Effective for Increasing Local Blood Circulation?
CONCLUSIONS Our findings do not support a therapeutic effect of wrinkling the skin with elastic tape application as a technique to increase local blood flow. PMID: 29332101 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Length of Stay and Functional Outcomes Among Patients with Stroke Discharged from an Inpatient Rehabilitation Facility in Saudi Arabia.
CONCLUSIONS A short or intermediate LOS is not necessarily associated with worse outcomes, assuming adequate care is provided. PMID: 29321468 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Actin Filament-Associated Protein 1-Like 1 Mediates Proliferation and Survival in Non-Small Cell Lung Cancer Cells.
CONCLUSIONS Our data show that AFAP1L1 promotes cell proliferation, accelerates cell cycle progression, and prevents cell apoptosis in lung cancer cells. Therefore, AFAP1L1 might play an oncogenic role in NSCLC. PMID: 29323101 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Oxidative Stress Levels and Antioxidant Enzyme Activities in Burst Fractures.
This study evaluated oxidative stress and antioxidant enzyme levels in burst fractures. MATERIAL AND METHODS Twenty patients with burst fractures were diagnosed and underwent surgery and 20 healthy control subjects were included in the study. Neurological status was evaluated using the American Spine Injury Association Impairment Scale (ASIA) before and after surgery. Neurological function was scored as ASIA A: complete deficits, ASIA B-D: incomplete deficits, and ASIA E: neurologically intact. Spectrophotometry was performed to measure malondialdehyde (MDA) and low glutathione (GSH), glutathione peroxidase (GPx) levels, w...
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Multislice Spiral Computed Tomography Perfusion Imaging for the Efficacy of Preoperative Concurrent Chemoradiotherapy in Middle-aged and Elderly Patients with Locally Advanced Gastric Cancer.
CONCLUSIONS MSCT might have predictive values for the efficacy of preoperative CCRT in the treatment of LAGC. PMID: 29326419 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Diosgenin Protects Rats from Myocardial Inflammatory Injury Induced by Ischemia-Reperfusion.
CONCLUSIONS Results demonstrate diosgenin plays an anti-inflammatory role in the protection of MIRI through regulation of p38-MAPK and JNK pathways and phosphorylation of NF-κB. PMID: 29329279 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of Phospholipase C ε (PLCε) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer.
CONCLUSIONS PLCε is an oncogene, and knockdown of expression of PLCe inhibits PCa cells proliferation via the PTEN/AKT signaling pathway. PMID: 29330357 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of mircoRNA-34a Enhances Survival of Human Bone Marrow Mesenchymal Stromal/Stem Cells Under Oxidative Stress.
CONCLUSIONS Our results suggest that miR-34a plays a key role in oxidative stress-induced MSC cell death, and targeting miR-34a might be a promising strategy to enhance the survival rate of engrafted stem cells, which may improve therapeutic outcome. PMID: 29331104 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Association Between Variants of Receptor for Advanced Glycation End Products (RAGE) Gene Polymorphisms and Age-Related Macular Degeneration.
CONCLUSIONS We revealed a significant association between RAGE gene rs1800624 and rs1800625 polymorphisms and AMD risk. We considered T allele at rs1800624 to be protective against AMD development, while allele G at rs1800625 was considered to be a marker of poor prognosis in AMD development. PMID: 29317590 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Subjective Complaints of Ocular Dryness and Xerostomia Among the Non-Sj ögren Adult Population of Lublin Region, Poland.
CONCLUSIONS Ocular dryness and concomitant xerostomia may occur in apparently healthy individuals, but is more frequent in patients with systemic disorders. The lack of dry eye and dry mouth symptoms does not exclude insufficient tearing and salivation; thus, the disorders are usually underestimated. Our study indicates that ocular and mouth dryness are the most common conditions seen in out-patients, due to increased use of medications, computers, and air conditioning. PMID: 29320472 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Methylene Blue Exerts Anticonvulsant and Neuroprotective Effects on Self-Sustaining Status Epilepticus (SSSE) Induced by Prolonged Basolateral Amygdala Stimulation in Wistar Rats.
CONCLUSIONS MB has a protective effect in the SSSE model and may be useful as an adjuvant for preventing or treating epilepsy in humans. PMID: 29307885 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Characteristics of Postprandial Proximal Gastric Acid Pocket in Gastroesophageal Reflux Disease.
In this study, we analyzed the characteristics of PPGAP in GERD. MATERIAL AND METHODS There were 17 normal participants and 20 GERD patients who completed a gastroesophageal reflux disease questionnaire (GerdQ) and underwent a gastroscopy, a high-resolution manometry, an esophageal 24-hour pH monitoring, and a station pull-through pH monitoring to assess their symptomatic degree, endoscopic change, acid exposure, and PPGAP. RESULTS PPGAP was present in all participants. Compared with normal participants, the PPGAP in GERD patients was significantly different, thus the disappearing time was significantly later (p
Source: Medical Science Monitor - January 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Diffusion Tensor Imaging in Diagnosis of Post-Traumatic Syringomyelia in Spinal Cord Injury in Rats.
Authors: Zhang C, Chen K, Han X, Fu J, Douglas P, Morozova AY, Abakumov MA, Gubsky IL, Li D, Guo J, Zhang X, Wang G, Chekhonin VP Abstract BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent of the individual SCI and PTS: a control group (n=10), a PTS group (n=8), and an SCI group (n=22). BBB tests were performed preoperatively and postoperatively at (...
Source: Medical Science Monitor - January 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Gremlin Regulates Podocyte Apoptosis via Transforming Growth Factor- β (TGF-β) Pathway in Diabetic Nephropathy.
CONCLUSIONS These results indicate that gremlin can aggravate podocyte lesions through the TGF-β signaling pathway, providing a novel therapeutic target for DN. PMID: 29315280 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of Annexin A11 (ANXA11) Inhibits Cell Proliferation, Invasion, and Migration via the AKT/GSK-3 β Pathway in Gastric Cancer.
CONCLUSIONS ANXA11 plays a critical role in regulating GC proliferation, migration, and invasion via the AKT/GSK-3β pathway, and can potentially be used as a prognostic factor and therapeutic target for gastric cancer patients. PMID: 29306955 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Applying a "Big Data" Literature System to Recommend Antihypertensive Drugs for Hypertension Patients with Diabetes Mellitus.
CONCLUSIONS The use of MedRank in ranking medical literature on hypertension with diabetes mellitus in our study suggests possible application in clinical practice; it is a potential method for supporting antihypertensive drug-prescription decisions. PMID: 29306956 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNAs Serve as Diagnostic Biomarkers of Preeclampsia and Modulate Migration and Invasiveness of Trophoblast Cells.
CONCLUSIONS NR_027457, AF085938, G36948, and AK002210 can serve as potential diagnostic biomarkers in preeclampsia, and NR_027457 and G36948 might be involved in the pathogenesis of preeclampsia. PMID: 29302021 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Femoral Artery Closure Versus Surgical Cutdown for Endovascular Aortic Repair: A Single-Center Experience.
Authors: Yang L, Liu J, Li Y Abstract BACKGROUND To compare the outcome and complication rates of femoral artery closure and surgical cutdown for endovascular aortic repair procedures (EVAR). MATERIAL AND METHODS Patients underwent either percutaneous femoral artery closure (PA group) or surgical cutdown (SC group) for EVAR between July 2011 and June 2016 and EVAR procedures were used for all cases. Data on outcomes and complications were collected and compared. RESULTS The SC group contained 55 patients and the PA group contained 60 patients and the technical success rates were 100.0% and 98.0%, respectively. The ...
Source: Medical Science Monitor - January 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Laser Application to the Root Surface Increases the Bonding Strength of Surface-Treated Prefabricated Glass-Fiber Posts in Teeth with Excessive Substance Loss.
This study examined the effect of roughening of the root surface using an erbium-doped yttrium aluminum garnet (Er: YAG) laser on the binding strength of teeth undergoing root canal treatment. MATERIAL AND METHODS Ninety single-rooted teeth were used and assigned randomly to 9 groups (n=10 each). Root canals were prepared using the FlexMaster rotary system. An Er: YAG laser was applied to the root canals in Group 1, with no surface treatment of the glass-fiber post. In Group 2, aluminum oxide particles were applied. In Group 3, the laser was applied to the root canals, with Cojet treatment. Group 4 received laser treatment...
Source: Medical Science Monitor - January 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Proprioceptive Changes in Bilateral Knee Joints Following Unilateral Anterior Cruciate Ligament Injury in Cynomolgus Monkeys.
CONCLUSIONS ACL injury leads to attenuation of proprioception on the injured side, and also leads to the attenuation of proprioception on the contralateral side, and there is a tendency could get worse over time. PMID: 29305572 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Human Papilloma Viruses and Their Genotype Distribution in Women with High Socioeconomic Status in Central Anatolia, Turkey: A Pilot Study.
CONCLUSIONS In this hospital-based retrospective analysis, HPV types were found to be similar to HPV types reported in developed countries. We firmly suggest that patients should be informed about the risk of HPV infection at early ages. PMID: 29298972 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Inhalation Anesthesia vs. Total Intravenous Anesthesia (TIVA) vs. Spinal-Epidural Anesthesia on Deep Vein Thrombosis After Total Knee Arthroplasty.
CONCLUSIONS The results obtained during the study established a clinical basis for comparative analysis of various anesthesia methods. We found that, compared with GA and CSEA, patients undergoing TIVA had a reduced rate of risk in relation to the occurrence of DVT following TKA. PMID: 29300003 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Anti-Osteoarthritic and Anti-Inflammatory Activities of Diazine: In Vitro and In Vivo Studies.
CONCLUSIONS The present findings demonstrated the chondroprotective effects of DZN via its modulation of the expressions of TIMP-1 and MMPs in the synovial tissues of osteoarthritic rats. PMID: 29300716 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Elevated Adenylyl Cyclase 9 Expression Is a Potential Prognostic Biomarker for Patients with Colon Cancer.
CONCLUSIONS High ADCY9 expression is a poor prognostic factor for disease-free survival in colon cancer. PMID: 29292367 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Risk Factors that Can Increase Possibility of Mandibular Canal Wall Damage in Adult: A Cone-Beam Computed Tomography (CBCT) Study in a Chinese Population.
CONCLUSIONS Most incomplete walls of MCs could be inferred by OPG. However, images based on CBCT could clarify the defect of the MC and also could clearly display the spatial relationship between the root and inferior alveolar canal. PMID: 29293490 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Construction and Comprehensive Analysis for Dysregulated Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Gastric Cancer.
In this study, we explored the functional roles and regulatory mechanisms of lncRNAs as ceRNAs in gastric cancer, and their potential implications for prognosis. The lncRNAs, miRNAs, and mRNAs expression profiles of 375 gastric cancer tissues and 32 non-tumor gastric tissues were downloaded from The Cancer Genome Atlas (TCGA) database. Differential expression of RNAs was identified using the DESeq package. Survival analysis was estimated based on Kaplan-Meier curve analysis. KEGG pathway analysis was performed using KOBAS 3.0. The dysregulated lncRNA-associated ceRNA network was constructed in gastric cancer based on bioin...
Source: Medical Science Monitor - January 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Magnetic Resonance Imaging on Treatment-Related Decision Making for Osteoporotic Vertebral Compression Fracture: A Prospective Randomized Trial.
Authors: Jin C, Xu G, Weng D, Xie M, Qian Y Abstract BACKGROUND The aim of this study was to analyze the impact and usefulness of characteristic signal change of a linear black signal on magnetic resonance imaging (MRI) on treatment-related decision making. MATERIAL AND METHODS Forty-one patients with a linear black signal on MRI were enrolled in this prospective study. They were randomly divided into the percutaneous kyphoplasty (PKP) group (n=24) and the conservative treatment group (n=17). Clinical measures, including visual analog scale (VAS) and short-form 36 (SF-36) questionnaire, were analyzed. Radiographic ...
Source: Medical Science Monitor - January 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats.
CONCLUSIONS The effect of emodin in fibrotic lung injury is closely related to its favorable properties of anti-inflammation and anti-oxidation. PMID: 29290631 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF- κB Signaling Pathway.
CONCLUSIONS Taken together, these findings suggest that fucoxanthin and TRAIL increased the apoptosis in human cervical cancer cells by targeting the PI3K/Akt/NF-κB signaling pathway. PMID: 29291370 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Rho/ROCK Pathway Regulates Migration and Invasion of Esophageal Squamous Cell Carcinoma by Regulating Caveolin-1.
Authors: Liu Z, Yu J, Wu R, Tang S, Cai X, Guo G, Chen S Abstract BACKGROUND Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. Caveolin-1 (Cav1) and Rho/ROCK pathway play important roles in tumor metastasis, separately. However, less research was focused on the relationship between Cav1 and Rho/ROCK in ECSS metastasis. Therefore, we investigated the relationship between Cav1 and Rho/ROCK pathway in ESCC metastasis. MATERIAL AND METHODS Cav1 and phosphorylated Cav1 (PY14Cav1) were examined in ESCC and in adjacent and non-tumorous tissues from ESCC patients by immunohistochemistry (IHC...
Source: Medical Science Monitor - January 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of CYP2C19 Genetic Polymorphism in a Large Ethnic Hakka Population in Southern China.
CONCLUSIONS Our study is the first to report on CYP2C19 polymorphisms in the Hakka population, and may help to optimize pharmacotherapy effectiveness by providing personalized medicine to this ethnic group in the near future. PMID: 29288619 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Outcomes and Predictors of Mortality After Mitral Valve Surgery in High-Risk Elderly Patients: The Heidelberg Experience.
CONCLUSIONS Octogenarians are increasingly represented in cardiac surgery and combined procedures. Prudent patient selection is necessary for optimizing postoperative outcomes among the elderly. In our seriously ill octogenarian cohort, mitral valve surgery was associated with moderate but acceptable mid-term survival. PMID: 29289956 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Surgical Treatment of Cardiac Tumors: Insights from an 18-Year Single-Center Analysis.
CONCLUSIONS Surgical treatment of cardiac tumors is a safe and highly effective strategy associated with good early and long-term outcomes. PMID: 29289957 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Assessment Tools for Use in Patients with M énière Disease: An Update.
Assessment Tools for Use in Patients with Ménière Disease: An Update. Med Sci Monit. 2017 Dec 28;23:6144-6149 Authors: Ciorba A, Skarżyński PH, Corazzi V, Bianchini C, Aimoni C, Hatzopoulos S Abstract A number of electrophysiological tests have been proposed for the initial diagnostic assessment or for the follow-up phase of patients affected by Ménière disease. The most common are: (i) vestibular evoked myogenic potentials (VEMPs); (ii) electrocochleography (ECochG); and (iii) otoacoustic emissions (OAEs). This paper presents the latest clinical developments with these 3 ...
Source: Medical Science Monitor - December 31, 2017 Category: Research Tags: Med Sci Monit Source Type: research