Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF- κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways
CONCLUSIONS The Zi Qi decoction inhibited liver fibrosis by inhibiting the TLR4-related NF-kB and MAPK signaling pathways and preventing activation of HSCs.PMID:33850093 | DOI:10.12659/MSM.929438 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 14, 2021 Category: Research Authors: Jingwen Zhou Xiaolong Zhang Lingfeng Wan Jun Yu Tianci Li Ziyu Lu Nanyuan Fang Lixia Sun Fang Ye Source Type: research

Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study
Med Sci Monit. 2021 Apr 13;27:e930176. doi: 10.12659/MSM.930176.ABSTRACTBACKGROUND Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. Nitric oxide synthase (iNOS) may be a factor regulating the vasodilation of blood vessels, which are relevant to ischemic-hypoxic conditions. We aimed to explore the potential relationship between iNOS and ICP. MATERIAL AND METHODS A prospective, case-control study was conducted including 77 pregnant women with ICP and 80 healthy pregnant women as controls. Enzyme-linked immunosorbent assays were used to inves...
Source: Medical Science Monitor - April 13, 2021 Category: Research Authors: Yun Wang Liping Zhu Duo Xu Liying Gao Yongmei Li Baoquan Liang Xiaoqian Zhang Yongfei Yue Source Type: research

Prostate Adenocarcinoma with Brain Metastasis: A Surveillance, Epidemiology, and End Results Database Analysis 2010-2015
CONCLUSIONS Our analysis shows that visceral metastasis is associated with a higher risk of brain metastasis. Presence of a visceral metastasis can be a useful parameter to consider early magnetic resonance imaging of the brain to facilitate diagnosis of asymptomatic brain metastasis.PMID:33840808 | DOI:10.12659/MSM.930064 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 12, 2021 Category: Research Authors: Zin W Myint Ayman H Qasrawi Source Type: research

Epidemiological and Clinical Characteristics of 217 Cases of COVID-19 in Jiangsu Province, China
Med Sci Monit. 2021 Apr 12;27:e930853. doi: 10.12659/MSM.930853.ABSTRACTBACKGROUND COVID-19 has become a worldwide epidemic disease and is a public health crisis. We aim to provide evidence for clinical diagnosis and assessment of severity by analyzing patients' clinical data and early laboratory results and exploring the correlation between laboratory results and clinical classification. MATERIAL AND METHODS We enrolled 283 cases of suspected and diagnosed COVID-19 from 16 hospitals in Jiangsu Province from January to April 2020. The routine laboratory blood examinations, T lymphocyte subsets, and biochemical and coagulat...
Source: Medical Science Monitor - April 12, 2021 Category: Research Authors: Jun Zhou Bing Chen Yali Wang Feng Wu Source Type: research

Analysis of Risk Factors for Thromboembolic Events in 88 Patients with COVID-19 Pneumonia in Wuhan, China: A Retrospective Descriptive Report
Med Sci Monit. 2021 Apr 11;27:e929708. doi: 10.12659/MSM.929708.ABSTRACTBACKGROUND Since the outbreak of COVID-19 in December 2019, there have been 96 623 laboratory-confirmed cases and 4784 deaths by December 29 in China. We aimed to analyze the risk factors and the incidence of thrombosis from patients with confirmed COVID-19 pneumonia. MATERIAL AND METHODS Eighty-eight inpatients with confirmed COVID-19 pneumonia were reported (31 critical cases, 33 severe cases, and 24 common cases). The thrombosis risk factor assessment, laboratory results, ultrasonographic findings, and prognoses of these patients were analyzed, and ...
Source: Medical Science Monitor - April 11, 2021 Category: Research Authors: Wenyu Wang Qingfeng Sun Yongxia Bao Ming Liang Qingwei Meng Hong Chen Jianing Li Hongliang Wang Huiqing Li Ying Shi Zhaoguo Li Xinyan Wang Shuai Zhao Hongwei Wang Jinling Xiao Liyan Chen Yan Zheng Di Wang Kaiyu Han Source Type: research

Clinical Application of Chromosomal Microarray Analysis in Pregnant Women with Advanced Maternal Age and Fetuses with Ultrasonographic Soft Markers
Med Sci Monit. 2021 Apr 10;27:e929074. doi: 10.12659/MSM.929074.ABSTRACTBACKGROUND In pregnant women with advanced maternal age (AMA) and fetuses with ultrasonographic (USG) soft markers it is always challenging to decide whether to implement chromosomal microarray analysis (CMA) or not. It is unclear whether CMA should be used in the fetuses with isolated USG soft markers, and there is still a lack of extensive sample research. MATERIAL AND METHODS We enrolled 1521 cases in our research and divided them into 3 groups as follows: pregnant women with isolated AMA (group 1, n=633), pregnant women whose fetuses had isolated U...
Source: Medical Science Monitor - April 10, 2021 Category: Research Authors: Zhu-Ming Hu Lei-Lei Li Han Zhang Hong-Guo Zhang Rui-Zhi Liu Yang Yu Source Type: research

A Review of the Current Status of Clinical Management of COVID-19 in the Elderly
This article reviews the effects of COVID-19 and makes management suggestions for elderly patients during this epidemic period. In addition to the elderly, critically ill people are also highly susceptible to this novel coronavirus. For elderly COVID-19 patients, antiviral therapy, immune regulation, and even auxiliary respiratory therapy can be given after a comprehensive evaluation of the disease. With the approval and use of COVID-19 vaccines, it is reasonable to expect that we can conquer SARS-CoV-2.PMID:33833211 | DOI:10.12659/MSM.930278 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 9, 2021 Category: Research Authors: Qiaoyun Li Chengyu Zhao Source Type: research

Current Status of MicroRNAs that Target the Wnt Signaling Pathway in Regulation of Osteogenesis and Bone Metabolism: A Review
This article aims to provide an update on the current status of microRNAs that target the Wnt signaling pathway in the regulation of osteogenesis and bone metabolism and includes a discussion of future areas of research, which can be a theoretical basis for bone metabolism-related diseases.PMID:33828067 | DOI:10.12659/MSM.929510 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 8, 2021 Category: Research Authors: Qiang Sun Siyu Liu Jingyi Feng Yue Kang You Zhou Shu Guo Source Type: research

Beyond Sociodemographic and COVID-19-Related Factors: The Association Between the Need for Psychological and Information Support from School and Anxiety and Depression
CONCLUSIONS In addition to sociodemographic and COVID-19-related aspects, students' needs for psychological assistance and information from schools were also associated with anxiety and depression among college students.PMID:33824264 | DOI:10.12659/MSM.929280 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 7, 2021 Category: Research Authors: Na Meng Zheng Liu Ya Wang Yan Feng Qin Liu Junqiang Huang Xiaolin Li Source Type: research

Retracted: Pancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest
Med Sci Monit. 2021 Mar 25;27:e932346. doi: 10.12659/MSM.932346.ABSTRACTAn editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures.Reference:Yong Xiong, Yi-Jia Xiong, Dong-Yang Liu, Rong-Rong Shen: Pancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest.Med Sci Monit 2019; 25:6015-6022. 10.12659/MSM.916116.PMID:33820903 | DOI:10.12659/MSM.932346 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2021 Category: Research Authors: Yong Xiong Yi-Jia Xiong Dong-Yang Liu Rong-Rong Shen Source Type: research

Impact of Cardiovascular Diseases on COVID-19: A Systematic Review
Med Sci Monit. 2021 Apr 6;27:e930032. doi: 10.12659/MSM.930032.ABSTRACTIn December 2019, pneumonia of unknown cause broke out, and currently more than 150 countries around the world have been affected. Globally, as of 5: 46 pm CET, 6 November 2020, the World Health Organization (WHO) had reported 48 534 508 confirmed cases of COVID-19, including 1 231 017 deaths. The novel coronavirus disease (COVID-19) outbreak, caused by the SARS-CoV-2 virus, is the most important medical challenge in decades. Previous research mainly focused on the exploration of lung changes. However, with development of the disease and deepening resea...
Source: Medical Science Monitor - April 6, 2021 Category: Research Authors: Qingtai Cao HanYu Lei MengLing Yang Le Wei YinMiao Dong JiaHao Xu Mi Nasser MengQi Liu Ping Zhu LinYong Xu MingYi Zhao Source Type: research

Retracted: Pancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest
Med Sci Monit. 2021 Mar 25;27:e932346. doi: 10.12659/MSM.932346.ABSTRACTAn editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures.Reference:Yong Xiong, Yi-Jia Xiong, Dong-Yang Liu, Rong-Rong Shen: Pancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest.Med Sci Monit 2019; 25:6015-6022. 10.12659/MSM.916116.PMID:33820903 | DOI:10.12659/MSM.932346 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 6, 2021 Category: Research Authors: Yong Xiong Yi-Jia Xiong Dong-Yang Liu Rong-Rong Shen Source Type: research

Impact of Cardiovascular Diseases on COVID-19: A Systematic Review
Med Sci Monit. 2021 Apr 6;27:e930032. doi: 10.12659/MSM.930032.ABSTRACTIn December 2019, pneumonia of unknown cause broke out, and currently more than 150 countries around the world have been affected. Globally, as of 5: 46 pm CET, 6 November 2020, the World Health Organization (WHO) had reported 48 534 508 confirmed cases of COVID-19, including 1 231 017 deaths. The novel coronavirus disease (COVID-19) outbreak, caused by the SARS-CoV-2 virus, is the most important medical challenge in decades. Previous research mainly focused on the exploration of lung changes. However, with development of the disease and deepening resea...
Source: Medical Science Monitor - April 6, 2021 Category: Research Authors: Qingtai Cao HanYu Lei MengLing Yang Le Wei YinMiao Dong JiaHao Xu Mi Nasser MengQi Liu Ping Zhu LinYong Xu MingYi Zhao Source Type: research

Effects of Different Exposure Days to Gonadotropin-Releasing Hormone Agonist (GnRH-a) on Live Birth Rates in the Depot GnRH-a Protocol: A Retrospective Analysis of 7007 Cycles
CONCLUSIONS In the depot GnRH-a protocol, live birth rates are higher among patients needing a longer time to achieve the goal of pituitary downregulation.PMID:33814548 | DOI:10.12659/MSM.929854 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 5, 2021 Category: Research Authors: Jianyuan Song Wei Wu Liu Jiang Cuicui Duan Jian Xu Source Type: research

Extra-Thyroid Extension Prediction by Ultrasound Quantitative Method Based on Thyroid Capsule Response Evaluation
CONCLUSIONS The calculation of L/V ratio by ultrasound could more precisely predict the ETE compared with manual judgment, which indirectly reflects the interaction between thyroid capsule and malignant nodules. The above conclusions need to be confirmed by a range of cases.PMID:33819211 | DOI:10.12659/MSM.929408 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 5, 2021 Category: Research Authors: Minghang Lin Yiming Su Weili Wei Yiran Gong Yinan Huang Jinshu Zeng Liya Li Haihong Shi Shuqiang Chen Source Type: research

Comparison of Endoscopy Alone with Surgery Converted from Endoscopy for the Removal of Esophageal Foreign Bodies in Adults: A Retrospective Study from a Single Center
CONCLUSIONS Larger foreign bodies that were found in the cervical or upper thoracic esophagus were associated with failed endoscopic removal and required surgical removal. Irregularly shaped or sharp foreign bodies, including dentures and fishbones, required surgical removal. These findings may guide future decisions of first-line approaches for the removal of esophageal foreign bodies.PMID:33813590 | DOI:10.12659/MSM.929142 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 4, 2021 Category: Research Authors: Yu Fang Zhiming Qin Source Type: research

Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway
CONCLUSIONS Our data demonstrated that DUSP12 suppressed MLEC injury in response to LPS insult by regulating the ASK1/JNK pathway.PMID:33811209 | DOI:10.12659/MSM.930429 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 3, 2021 Category: Research Authors: Zhao Hui Huang Jie Guo-Hua Fan Source Type: research

In Silico Network Analysis of Ingredients of Cornus officinalis in Osteoporosis
CONCLUSIONS We found the possible mechanisms of CO in treating osteoporosis may be based on multiple targets and pathways. We also provided a theoretical basis and promising direction for investigating the exact anti-osteoporotic mechanisms of CO.PMID:33795629 | DOI:10.12659/MSM.929219 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 2, 2021 Category: Research Authors: Feiqi Huang Huizhi Guo Yuanbiao Wei Xiao Zhao Yangsheng Chen Zhan Lin Yanhui Zhou Ping Sun Source Type: research

Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology
CONCLUSIONS In conclusion, metabolomics combined with network pharmacology research strategy revealed that fluorofenidone has a multi-target and multi-path mechanism of action in the treatment of pulmonary fibrosis.PMID:33790218 | DOI:10.12659/MSM.930166 (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 1, 2021 Category: Research Authors: Feiya Jiang Tongtong Wang Sha Li Yu Jiang Zhuo Chen Wen Liu Source Type: research

Comparison of the Effects of a Bean-Based and a White Rice-Based Breakfast Diet on Postprandial Glucose and Insulin Levels in Chinese Patients with Type 2 Diabetes
CONCLUSIONS Compared with a white rice-based breakfast, a bean-based diet significantly reduced postprandial glucose levels and promoted insulin secretion. These results support a dietary approach to reduce postprandial hyperglycemia.PMID:33785707 | DOI:10.12659/MSM.930349 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 31, 2021 Category: Research Authors: Qing Xiong Zhiming Li Rongjie Nie Xubiao Meng Xue-Jun Yang Source Type: research

Connection Between CDC20 Expression and Hepatocellular Carcinoma Prognosis
In this study, we discuss a potential link of CDC20 expression to HCC patients' prognoses. MATERIAL AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess CDC20 expression in HCC and the paired noncancerous tissues. Chi-square analysis was used to assess potential association of CDC20 expression with clinicopathologic profiles among HCC patients. The overall survival for HCC patients with different CDC20 expressions was assessed using the Kaplan-Meier method. To evaluate the prognostic value for HCC patients, Cox regression analyses were performed. RESULTS The expression of CDC20 was...
Source: Medical Science Monitor - March 31, 2021 Category: Research Authors: Xianfeng Zhang Xianjun Zhang Xinguo Li Hongbing Bao Guang Li Ning Li Hengli Li Jian Dou Source Type: research

Comparison of the Effects of a Bean-Based and a White Rice-Based Breakfast Diet on Postprandial Glucose and Insulin Levels in Chinese Patients with Type 2 Diabetes
CONCLUSIONS Compared with a white rice-based breakfast, a bean-based diet significantly reduced postprandial glucose levels and promoted insulin secretion. These results support a dietary approach to reduce postprandial hyperglycemia.PMID:33785707 | DOI:10.12659/MSM.930349 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 31, 2021 Category: Research Authors: Qing Xiong Zhiming Li Rongjie Nie Xubiao Meng Xue-Jun Yang Source Type: research

Connection Between CDC20 Expression and Hepatocellular Carcinoma Prognosis
In this study, we discuss a potential link of CDC20 expression to HCC patients' prognoses. MATERIAL AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess CDC20 expression in HCC and the paired noncancerous tissues. Chi-square analysis was used to assess potential association of CDC20 expression with clinicopathologic profiles among HCC patients. The overall survival for HCC patients with different CDC20 expressions was assessed using the Kaplan-Meier method. To evaluate the prognostic value for HCC patients, Cox regression analyses were performed. RESULTS The expression of CDC20 was...
Source: Medical Science Monitor - March 31, 2021 Category: Research Authors: Xianfeng Zhang Xianjun Zhang Xinguo Li Hongbing Bao Guang Li Ning Li Hengli Li Jian Dou Source Type: research

Finite Element Analysis of Femoral Neck Fracture Treated with Bidirectional Compression-Limited Sliding Screw
CONCLUSIONS The FEA showed that compared with the CS, the new BCLSC showed better performance in resisting shearing force for Pauwels III femoral neck fracture, with better mechanical properties. These data provide a basis for further experiments and clinical application.PMID:33782376 | DOI:10.12659/MSM.929163 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2021 Category: Research Authors: Hai Huang Zhengkuan Feng Weifei Wang Cheng Yang Jianwen Liao Jun Ouyang Source Type: research

Prognostic Nomograms to Predict Survival of Patients with Resectable Gallbladder Cancer: A Surveillance, Epidemiology, and End Results (SEER)-Based Analysis
CONCLUSIONS The constructed nomograms showed better discrimination abilities to predict OS and CSS rates at 1, 3, and 5 years. In the future, these constructed models for this disease will assist in risk stratification to guide GBAC treatment.PMID:33784268 | DOI:10.12659/MSM.929106 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2021 Category: Research Authors: Yan Lin Hua Chen Fan Pan Source Type: research

A Real-World Study on the Use of the Alcohol Use Disorders Identification Test (AUDIT) in Men Admitted to a Psychiatric Hospital
Med Sci Monit. 2021 Mar 29;27:e929667. doi: 10.12659/MSM.929667.ABSTRACTBACKGROUND This real-world study aimed to investigate the use of the Alcohol Use Disorders Identification Test (AUDIT) in men admitted to a psychiatric hospital. MATERIAL AND METHODS The AUDIT questionnaire (10 items) was consecutively administered for a period of 3 years to male patients admitted to a psychiatric hospital (n=636). Laboratory blood tests of biochemical parameters were measured as biomarkers of alcohol consumption. Data were evaluated using linear models with mixed effects in the case of continuous dependent variables and logistic regre...
Source: Medical Science Monitor - March 29, 2021 Category: Research Authors: Martin Anders Eva Kitzlerov á Sylva Rackov á V áclav Ćapek Source Type: research

Effects of Synchronized Neuromuscular Electrical Stimulation (NMES) on the Submental Muscles During Ingestion of a Specified Volume of Soft Food in Patients with Mild-to-Moderate Dysphagia Following Stroke
This study aimed to evaluate the effects of synchronized NMES on the submental muscles during ingestion of a specified volume of soft food in patients with mild-to-moderate dysphagia following stroke. MATERIAL AND METHODS Eighty-three patients with mild-to-moderate dysphagia following stroke were enrolled and randomly divided into 3 groups: conventional training (CT) (n=28), eating training (ET) (n=28), and intensive swallowing training (IST) (n=27). The CT group received conventional swallow training, the ET group was given additional individual feedings with a specified volume of soft food, and the IST group received int...
Source: Medical Science Monitor - March 29, 2021 Category: Research Authors: Qian Zhang Shuang Wu Source Type: research

A Real-World Study on the Use of the Alcohol Use Disorders Identification Test (AUDIT) in Men Admitted to a Psychiatric Hospital
Med Sci Monit. 2021 Mar 29;27:e929667. doi: 10.12659/MSM.929667.ABSTRACTBACKGROUND This real-world study aimed to investigate the use of the Alcohol Use Disorders Identification Test (AUDIT) in men admitted to a psychiatric hospital. MATERIAL AND METHODS The AUDIT questionnaire (10 items) was consecutively administered for a period of 3 years to male patients admitted to a psychiatric hospital (n=636). Laboratory blood tests of biochemical parameters were measured as biomarkers of alcohol consumption. Data were evaluated using linear models with mixed effects in the case of continuous dependent variables and logistic regre...
Source: Medical Science Monitor - March 29, 2021 Category: Research Authors: Martin Anders Eva Kitzlerov á Sylva Rackov á V áclav Ćapek Source Type: research

Effects of Synchronized Neuromuscular Electrical Stimulation (NMES) on the Submental Muscles During Ingestion of a Specified Volume of Soft Food in Patients with Mild-to-Moderate Dysphagia Following Stroke
This study aimed to evaluate the effects of synchronized NMES on the submental muscles during ingestion of a specified volume of soft food in patients with mild-to-moderate dysphagia following stroke. MATERIAL AND METHODS Eighty-three patients with mild-to-moderate dysphagia following stroke were enrolled and randomly divided into 3 groups: conventional training (CT) (n=28), eating training (ET) (n=28), and intensive swallowing training (IST) (n=27). The CT group received conventional swallow training, the ET group was given additional individual feedings with a specified volume of soft food, and the IST group received int...
Source: Medical Science Monitor - March 29, 2021 Category: Research Authors: Qian Zhang Shuang Wu Source Type: research

Biomechanical Behavior of All-on-4 and M-4 Configurations in an Atrophic Maxilla: A 3D Finite Element Method
CONCLUSIONS To promote better primary stabilization, M-4 or short implant configurations with canine-guided occlusion appear to be preferable for patients who have severe atrophy in the anterior maxilla.PMID:33774647 | DOI:10.12659/MSM.929908 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 28, 2021 Category: Research Authors: Delal Bozyel Simge Ta şar Faruk Source Type: research

Use of the Water-Soluble Contrast Medium Gastrografin in Treatment of Adhesive Small Bowel Obstruction in Patients with and Without Chronic Radiation Enteropathy: A Single-Center Retrospective Study
Med Sci Monit. 2021 Mar 27;27:e930046. doi: 10.12659/MSM.930046.ABSTRACTBACKGROUND This retrospective cohort study from a single center aimed to compare patient outcomes following the use of the water-soluble contrast medium Gastrografin in the treatment of adhesive small bowel obstruction (ASBO) in patients with and without a history of chronic radiation enteropathy (CRE). MATERIAL AND METHODS Fifty-nine patients with CRE-induced small bowel obstruction (SBO) and 53 patients with ASBO at Jinling Hospital between April 2014 and February 2018 were enrolled. The patients were given 100 ml Gastrografin through a naso-jejunal ...
Source: Medical Science Monitor - March 27, 2021 Category: Research Authors: Lili Gu Feng Zhu Tingbin Xie Dengyu Feng Jianfeng Gong Ning Li Source Type: research

Developmental Patterns of Fecal Bile Acids in Healthy Neonates and Children
CONCLUSIONS The liver can effectively synthesize primary bile acids 7 days after birth, and fecal primary bile acids tend to be stable after the neonate stage. Secondary bile acids continuously increase along with the maturation of intestinal flora, which reaches a relatively stable level at around 3 years old.PMID:33767128 | DOI:10.12659/MSM.928214 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 26, 2021 Category: Research Authors: Jing-Jing Xiong Hong-Wei Hu Chuan-Zhi Xu Jian-Wen Yin Mei Liu Li-Zhi Zhang Yong Duan Yong-Kun Huang Source Type: research

Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) Pathway
CONCLUSIONS SAA protected EPCs against high-glucose-induced dysfunction via the AKT/eNOS pathway.PMID:33770068 | DOI:10.12659/MSM.928153 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 26, 2021 Category: Research Authors: Yanhua Guan Xu Wang Source Type: research

Developmental Patterns of Fecal Bile Acids in Healthy Neonates and Children
CONCLUSIONS The liver can effectively synthesize primary bile acids 7 days after birth, and fecal primary bile acids tend to be stable after the neonate stage. Secondary bile acids continuously increase along with the maturation of intestinal flora, which reaches a relatively stable level at around 3 years old.PMID:33767128 | DOI:10.12659/MSM.928214 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 26, 2021 Category: Research Authors: Jing-Jing Xiong Hong-Wei Hu Chuan-Zhi Xu Jian-Wen Yin Mei Liu Li-Zhi Zhang Yong Duan Yong-Kun Huang Source Type: research

Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) Pathway
CONCLUSIONS SAA protected EPCs against high-glucose-induced dysfunction via the AKT/eNOS pathway.PMID:33770068 | DOI:10.12659/MSM.928153 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 26, 2021 Category: Research Authors: Yanhua Guan Xu Wang Source Type: research

Retracted: Xanthoxyletin Inhibits Proliferation of Human Oral Squamous Carcinoma Cells and Induces Apoptosis, Autophagy, and Cell Cycle Arrest by Modulation of the MEK/ERK Signaling Pathway
Med Sci Monit. 2021 Mar 25;27:e932349. doi: 10.12659/MSM.932349.ABSTRACTRetracted, due to breach of publishing guidelines, following the identification of non-original and manipulated figure images. Reference: Qingquan Wen, Kai Luo, Haiyan Huang, Weiguo Liao, Hong Yang: Xanthoxyletin Inhibits Proliferation of Human Oral Squamous Carcinoma Cells and Induces Apoptosis, Autophagy, and Cell Cycle Arrest by Modulation of the MEK/ERK Signaling Pathway. Med Sci Monit 2019; 25:8025-8033. 10.12659/MSM.911697.PMID:33762554 | DOI:10.12659/MSM.932349 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2021 Category: Research Authors: Qingquan Wen Kai Luo Haiyan Huang Weiguo Liao Hong Yang Source Type: research

Retracted: Anthecotulide Sesquiterpene Lactone Exhibits Selective Anticancer Effects in Human Malignant Melanoma Cells by Activating Apoptotic and Autophagic Pathways, S-Phase Cell Cycle Arrest, Caspase Activation, and Inhibition of NF- κB Signalling Pathway
Med Sci Monit. 2021 Mar 25;27:e932353. doi: 10.12659/MSM.932353.ABSTRACTRetracted, due to breach of publishing guidelines, following the identification of non-original and manipulated figure images. Reference: Chenyang Li, Xiuping Han: Anthecotulide Sesquiterpene Lactone Exhibits Selective Anticancer Effects in Human Malignant Melanoma Cells by Activating Apoptotic and Autophagic Pathways, S-Phase Cell Cycle Arrest, Caspase Activation, and Inhibition of NF-kappaB Signalling Pathway. Med Sci Monit 2019; 25:2852-2858. 10.12659/MSM.913771.PMID:33762555 | DOI:10.12659/MSM.932353 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2021 Category: Research Authors: Chenyang Li Xiuping Han Source Type: research

Retracted: Taxol-Resistant Gene 1 (Txr1) Mediates Oxaliplatin Resistance by Inducing Autophagy in Human Nasopharyngeal Carcinoma Cells
Med Sci Monit. 2021 Mar 25;27:e932332. doi: 10.12659/MSM.932332.ABSTRACTAn editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures. Reference: Hua-ming Chi, Jing-dong Du, Jie Cheng, Hua-dong Mao: Taxol-Resistant Gene 1 (Txr1) Mediates Oxaliplatin Resistance by Inducing Autophagy in Human Nasopharyngeal Carcinoma Cells. Med Sci Monit 2019; 25:475-483. 10.12659/MSM.913180.PMID:33762556 | DOI:10.12659/MSM.932332 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2021 Category: Research Authors: Hua-Ming Chi Jing-Dong Du Jie Cheng Hua-Dong Mao Source Type: research

Retracted: Antitumor Effects of 8-Deoxylactucin in RB355 Human Retinoblastoma Cells Are Mediated via Apoptosis Induction, Reactive Oxygen Species Production, and Cell Cycle Arrest
Med Sci Monit. 2021 Mar 25;27:e932344. doi: 10.12659/MSM.932344.ABSTRACTAn editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures. Reference: Tan Guiying, Li Yue, Xiong Chao, Yu Jinhai, Xu Qihua: Antitumor Effects of 8-Deoxylactucin in RB355 Human Retinoblastoma Cells Are Mediated via Apoptosis Induction, Reactive Oxygen Species Production, and Cell Cycle Arrest. Med Sci Monit 2019; 25:4575-4582. 10.12659/MSM.914242.PMID:33762557 | DOI:10.12659/MSM.932344 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2021 Category: Research Authors: Tan Guiying Li Yue Xiong Chao Yu Jinhai Xu Qihua Source Type: research

Retracted: Phillygenin Exerts In Vitro and In Vivo Antitumor Effects in Drug-Resistant Human Esophageal Cancer Cells by Inducing Mitochondrial-Mediated Apoptosis, ROS Generation, and Inhibition of the Nuclear Factor kappa B NF- κB Signalling Pathway
Med Sci Monit. 2021 Mar 25;27:e932333. doi: 10.12659/MSM.932333.ABSTRACTAn editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures. Reference: Jiantao He, Wei Wei, Qingbo Yang, Yiling Wang: Phillygenin Exerts In Vitro and In Vivo Antitumor Effects in Drug-Resistant Human Esophageal Cancer Cells by Inducing Mitochondrial-Mediated Apoptosis, ROS Generation, and Inhibition of the Nuclear Factor kappa B NF-kappaB Signalling Pathway. Med Sci Monit 2019; 25:739-745. 10.12659/MSM.913138.PMID:33762558 | DOI:10.12659/MSM...
Source: Medical Science Monitor - March 25, 2021 Category: Research Authors: Jiantao He Wei Wei Qingbo Yang Yiling Wang Source Type: research

Retracted: Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells
Med Sci Monit. 2021 Mar 25;27:e932339. doi: 10.12659/MSM.932339.ABSTRACTAn editorial decision has been made to retract this manuscript due to breach of publishing guidelines, following the identification of non-original and manipulated figures. Reference: Jingbao Zhang, Yanfei Gao, Changbo Ma, Yi Wang: Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells. Med Sci Monit 2019; 25:2002-2008. 10.12659/MSM.913873.PMID:33762559 | DOI:10.12659/MSM.932339 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 25, 2021 Category: Research Authors: Jingbao Zhang Yanfei Gao Changbo Ma Yi Wang Source Type: research