Long Noncoding RNA FEZF1-AS1 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer by Activation of JAK-STAT3 Pathway.
CONCLUSIONS Our study demonstrated that FEZF1-AS1 exerted an oncogenic role in ovarian cancer via modulating JAK-STAT3 pathway. PMID: 30416194 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Heat Shock Protein 70 (HSP70) Reduces Hepatic Inflammatory and Oxidative Damage in a Rat Model of Liver Ischemia/Reperfusion Injury with Hyperbaric Oxygen Preconditioning.
This study aimed to determine the mechanism of the protective effect of hyperbaric oxygen preconditioning (HBO₂P) on hepatic ischemia/reperfusion (I/R) injury in a rat model, and to investigate the effects on HBO₂P and I/R injury of blocking HSP70 using antibody (Ab) pretreatment. MATERIAL AND METHODS Male Sprague-Dawley rats underwent HBO₂P for 60 min at 2.0 atmosphere absolute (ATA) pressure for five consecutive days before surgical hepatic I/R injury, performed by clamping the portal vein and hepatic lobe. Four groups studied included: the non-HBO₂P+ non-I/R group, which underwent sham surgery (N=10); the non-HB...
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway.
Authors: Li BH, Wang Y, Wang CY, Zhao MJ, Deng T, Ren XQ Abstract BACKGROUND The purpose of the study was to investigate the functional roles of phosphatase in regenerating liver-3 (PRL-3) in hepatocellular carcinoma (HCC), as well as the related molecular mechanisms. MATERIAL AND METHODS HCC tissues and adjacent normal tissues were collected from 124 HCC patients. The mRNA and protein levels of PRL-3 were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, respectively. The relationship between PRL-3 expression and clinical characteristics of HCC patients was evaluate...
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Study on Complications of Intracranial Ruptured Aneurysm Embolization by Stent-Assisted Coil.
CONCLUSIONS Stent-assisted coil embolization is safe, effective, and feasible for the treatment of intracranial ruptured aneurysms. Patients had a favorable outcome of as high as 94.4%. However, clinical skills should be improved to reduce the occurrence of complications. Prompt and timely treatment for complications of intracranial ruptured aneurysm is also of great significance. PMID: 30419569 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Molecular Regulation of the Cox2 Gene in Gastroenteropancreatic Neuroendocrine Tumors and Antiproliferation of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs).
CONCLUSIONS The majority of GEP-NETs over express cox-2 gene. The binding of CREB and USF-1/-2 transcription factors to a proximal, overlapping CRE-Ebox element is the underlying mechanism for cox-2 gene expression. NSAIDs potently suppressed the proliferations and may offer a novel approach for chemoprevention and therapy of GEP-NETs. PMID: 30420588 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Inertia in Type 2 Diabetes Patients in Primary Health Care Clinics in Central Bosnia.
CONCLUSIONS For better regulation of glycemia and reduction of clinical inertia with type 2 diabetes patients, more specialized training is needed for selected physicians. Strengthening of primary healthcare and encouraging doctors to perform procedures can contribute to better outcomes of treatment, lower clinical inertia, and better education of patients. PMID: 30421728 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Hyperbaric Oxygen on Tissue Healing around Dental Implants in Beagles.
Authors: Liao J, Wu MJ, Mu YD, Li P, Go J Abstract BACKGROUND The impact of hyperbaric oxygen (HBO) on the healing of soft tissues around dental implants was studied in a beagle model. MATERIAL AND METHODS Beagle dogs were randomized to receive implants, followed by postoperative HBO therapy or not (n=10 per group). On postoperative days 3, 7, and 14, tissue specimens were paraffin-embedded and analyzed by hematoxylin-eosin and Masson staining, as well as immunohistochemistry against CD31. RESULTS Scores for inflammation pathology based on hematoxylin-eosin staining and mean optical density of collagen fibers were ...
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of Botulinum Toxin Type A in Spasticity Caused by Spinal Cord Injury: A Randomized, Controlled Trial.
The objective of this study was to compare the efficacy and safety of botulinum toxin type A versus baclofen in spasticity. MATERIAL AND METHODS A total of 336 patients who had spasticity caused by spinal cord injury were enrolled in a randomized (in 1: 1: 1: ratio) for placebo, controlled trial. Patients had received baclofen (BA group, n=112), local intramuscular injection of 500 U Botulinum toxin type A (BTI group, n=112), or physical therapies alone (placebo group, n=112). Modified Ashworth scale (mAS) score, disability assessment scale (DAS) score, modified medical research council (mMRC) score, the Barthel Index (BI)...
Source: Medical Science Monitor - November 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Silencing the FOLR2 Gene Inhibits Cell Proliferation and Increases Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via Inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 Kinase 1 (S6K1) Signaling.
CONCLUSIONS Silencing of the FOLR2 gene inhibited phosphorylation of AKT, mTOR, and S6K1, inhibited cell proliferation and increased apoptosis in the NCI-H1650 human NSCLC cell line. PMID: 30415267 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

A Propensity Score-Matched Analysis for Non-Intubated Thoracic Surgery.
Authors: Lan L, Cen Y, Zhang C, Qiu Y, Ouyang B Abstract BACKGROUND Most observations of non-intubated anesthesia under spontaneous breathing are small-cohort, non-homogeneous surgery types and lack an intubation control. We therefore retrospectively compared the perioperative conditions and postoperative recovery of non-intubated video-assisted thoracoscopic surgery (NIVATS group) and intubated VATS (IVATS group) with a propensity score-matching analysis. MATERIAL AND METHODS We case-matched 119 patients in the NIVATS group with patients in the IVATS group by a propensity score-matched analysis. All of them underw...
Source: Medical Science Monitor - November 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/ β-Catenin Pathway.
CONCLUSIONS Our results validate the tumor-inhibition effect of IC-2 on bladder cancer in vivo and in vitro, providing a novel therapeutic strategy for bladder cancer. PMID: 30415269 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Silencing of Xeroderma Pigmentosum Group D Gene Promotes Hepatoma Cell Growth by Reducing P53 Expression.
This study investigated the effect of xeroderma pigmentosum group D (XPD) silencing on the growth of hepatoma cells and assessed the mechanisms. MATERIAL AND METHODS XPD gene was silenced by siRNA in hepatoma cells. The experiments were randomly divided into a control group, a liposome control group, a negative control (NC) group, an XPD siRNA group, and an XPD siRNA + P53 inhibitor group. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) was used to detect cell viability 24 h after gene silencing and treatments. Terminal deoxynucleotidyl transferases (TdT)-mediated dUTP nick-end labeling (TUNEL) and flow ...
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

A Potential Competitive Endogenous RNA Pathway Involved in Chronic Spinal Cord Injury.
CONCLUSIONS Our results showed that the abundance of DE lncRNAs may be associated with the risk of CSCI outcome and revealed a potential competitive endogenous RNA (ceRNA) pathway involved in CSCI. Further experiments in vivo and in vitro were essential to uncover the exact mechanism of this ceRNA pathway. PMID: 30411720 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma.
CONCLUSIONS Our study demonstrated that low expression of TRIM15 in gastric adenocarcinoma tissues was significantly associated with poorer prognosis of patients, indicating the potential of TRIM15 as a novel clinical biomarker and therapeutic target. PMID: 30412518 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

A Survey of Current Prophylactic Treatment for Ophthalmia Neonatorum in Croatia and a Review of International Preventive Practices.
CONCLUSIONS A survey of all 32 maternity hospitals in Croatia showed variation in the prevalence of preventive treatment for ophthalmia neonatorum and the methods used. These findings support the need to implement standardized preventive measures that both conform to international clinical guidelines and recognize treatment availability in Croatia, where topical povidone-iodine is currently preferred for the prevention of ophthalmia neonatorum. PMID: 30413681 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Erythromycin on the Proliferation and Apoptosis of Cultured Nasal Polyp-Derived Cells and the Extracellular Signal-Regulated Kinase (ERK)/Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway.
CONCLUSIONS In cultured cells derived from nasal polyps, erythromycin treatment reduced cell proliferation and increased apoptosis by inhibiting the activation of the ERK/MAPK signaling pathway. PMID: 30414267 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Agreement and Repeatability of Two Biometers to Measure Anterior Segment Components: Refractive Error Effect.
CONCLUSIONS The repeatability of the Cirrus OCT and Sirius Scheimpflug instrument was good and independent of the refractive error. Nevertheless, to judge whether these instruments could be used interchangeable, clinical criteria are needed. PMID: 30414377 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 11, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of gonadotropin-releasing hormone (GnRH) Agonists Triptorelin Acetate and Cetrorelix Acetate in Assisted Reproduction.
Authors: Jiang J, Gao S, Xu J Abstract BACKGROUND The aim of this study was to compare the efficacy and safety of 2 GnRH agonists - triptorelin acetate and cetrorelix acetate - in assisted reproduction. MATERIAL AND METHODS A total of 182 females who received in vitro fertilization and embryo transfer (IVF+ET) from March 2014 to July 2014 were involved, and their clinical data were retrospectively analyzed. Among them, 91 patients received treatment with short-acting triptorelin (group A) and another 91 patients were treated with cetrorelix acetate (group B). Fasting blood was extracted from each patient on the day...
Source: Medical Science Monitor - November 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Tumor Volume Reduction After Gemcitabine Plus Cisplatin Induction Chemotherapy in Locally Advanced Nasopharyngeal Cancer: Comparison with Paclitaxel and Cisplatin Regimens.
CONCLUSIONS Changes in the tumor volume and nasopharyngeal air cavity showed that the GP regimen was significantly more effective than the TP regimen in tumor burden reduction. However, whether the advantages of GP can translate into survival benefits requires further investigation. PMID: 30406770 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Bacteriocin Isolated from Lactobacillus Rhamnosus L34 Has Antibacterial Effects in a Rabbit Model of Infection After Mandible Fracture Fixation.
CONCLUSIONS Use of bacteriocins isolated from Lactobacillus rhamnosus L34 may be a promising way to control infections of mandible fracture after internal fixation in vivo. PMID: 30408016 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of a Novel General Pituitary Hormone Score to Evaluate the Function of the Residual Anterior Pituitary (Adenohypophysis) in Patients Following Surgery for Pituitary Adenoma.
Authors: Wang S, Ding C, Xiao D, Wu Z, Wei L Abstract BACKGROUND The aim was to develop and assess a general pituitary hormone score to evaluate the function of the anterior pituitary (adenohypophysis) in patients following resection of pituitary adenomas. MATERIAL AND METHODS Sixty-six patients with pituitary null cell macroadenoma (1-3 cm diameter) (N=38) and pituitary null cell giant adenoma (≥3 cm diameter) (N=28) had preoperative and postoperative data including magnetic resonance imaging (MRI) and measurement of six pituitary hormones levels, adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid...
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Diagnostic Value of Assessment of Cervical Involvement in Early-Stage Endometrial Adenocarcinoma: Comparison of Magnetic Resonance Imaging (MRI) Versus Hysteroscopy.
CONCLUSIONS MRI is better than HS for cervical assessment. The negative predictive values of both MRI and HS are high and unsatisfactory. PMID: 30398217 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Evaluation of a Polish Translation and Cross-Cultural Adaptation of the Nasal Obstruction Symptom Evaluation (NOSE) Scale.
CONCLUSIONS The Polish version of the NOSE scale is a brief and reproducible clinical evaluation tool for use in clinical practice in Polish-speaking patients with nasal obstruction. PMID: 30399140 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Differential Expression Pattern of Exosome Long Non-Coding RNAs (lncRNAs) and MicroRNAs (miRNAs) in Vascular Endothelial Cells Under Heat Stroke.
CONCLUSIONS These results indicate that the identified lncRNAs and miRNAs in endothelial cell exosomes might serve as non-invasive biomarkers for heat stroke. PMID: 30399613 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Correlations of Inflammatory Factors with Intestinal Flora and Gastrointestinal Incommensurate Symptoms in Children with Asthma.
Authors: Zhang Y, Li T, Yuan H, Pan W, Dai Q Abstract BACKGROUND Bronchial asthma is a common pediatric disease, the pathogenesis of which is complicated. The correlations of the levels of inflammatory factors in peripheral serum with intestinal flora and gastrointestinal incommensurate symptoms in children with asthma remain to be further elucidated. MATERIAL AND METHODS A total of 70 children diagnosed with asthma in the Pediatric Department of our hospital from February 2016 to March 2017 were enrolled as an observation group, and another 25 healthy children in the same age range were selected as a control group...
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effect of Anthocyanin on Paraquat-Induced Apoptosis and Epithelial-Mesenchymal Transition in Alveolar Type II Cells.
CONCLUSIONS Our study shows newly discovered effects of anthocyanidins on EMT and supports their chemopreventive effects in paraquat-induced apoptosis in alveolar type II cells. PMID: 30403199 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Correlation of Expression Levels of Micro Ribonucleic Ccid-10b (miR-10b) and Micro Ribonucleic Acid-181b (miR-181b) with Gastric Cancer and Its Diagnostic Significance.
Authors: Gao Y, Xu Z, Yuan F, Li M Abstract BACKGROUND The aim of this study was to explore the expression levels of micro ribonucleic acid-10b (miR-10b) and micro ribonucleic acid-181b (miR-181b) in gastric cancer tissues, as well as their application value in clinical diagnosis and treatment. MATERIAL AND METHODS A total of 120 patients with gastric cancer who were diagnosed and treated in the Department of Gastroenterology of our hospital were enrolled in this study. The gastric cancer tissues and paracancerous tissues were collected for measuring the expression of miR-10b and miR-181b by in situ hybridization a...
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Therapeutic Advantages of Internal Fixation with Kirschner Wire and Bone Grafting via Limited Tarsal Sinus Incision Approach for Displaced Intra-Articular Calcaneal Fractures of Children.
This study investigated therapeutic effects of internal fixation with Kirschner wire and bone grafting via limited tarsal sinus incision in pediatric DIACF. MATERIAL AND METHODS This retrospective study included pediatric DIACF patients admitted to our department from June 2010 to February 2014. Patients were divided into Sanders II, Sanders III, and Sanders IV groups. Patients were also divided into pre-operation and post-operation groups. All patients underwent the internal fixation with Kirschner wire and bone grafting via limited tarsal sinus incision operation. Bohler angles, Gissane angles, and modified American Orth...
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression of Bax/Bcl-2, TGF- β1, and Type III Collagen Fiber in Congenital Muscular Torticollis.
This study investigated the expression of Bax/Bcl-2, TGF-β1 and type III collagen fiber in sternocleidomastoid of congenital muscular torticollis (CMT), and explored the possible mechanisms of fibrosis in sternocleidomastoid of CMT. MATERIAL AND METHODS The localization and expression of Bax, Bcl-2, TGF-β1, and type III collagen were detected in the control group and experimental group by using immunohistochemical staining method. The RT-PCR assay was used to measure the expression of TGF-β1 in the control group and experimental group. RESULTS HE staining results showed that the collagen fiber in the experim...
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Downregulated Expression of Tropomyosin 1 in Intrahepatic Cholangiocarcinoma: A Predictor of Recurrence and Prognosis.
Authors: Chen Y, Hong Z, Lu S, Zhang N, Rong G, Chang X, Liu Z, Bai W, Dong Z, Gao X, Zeng Z, Lu Y Abstract BACKGROUND The downregulation of tropomyosin 1 (TPM1) has been observed in various tumors, but few studies have focused on the clinical significance of TPM1 in intrahepatic cholangiocarcinoma (ICC). In the present study, we investigated the prognostic significance of TPM1 in ICC. MATERIAL AND METHODS A total of 124 patients with ICC were enrolled in this study. Quantitative real-time polymerase chain reaction (qRT-RCR) was performed to examine the mRNA levels of TPM1 in ICC tissue samples and adjacent noncanc...
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Delivery Mode and Pelvic Organ Prolapse Evaluated by Four-Dimensional Pelvic Floor Ultrasonography.
CONCLUSIONS Four-dimensional pelvic floor ultrasonography can be used as a preferred method in evaluating POP. Regarding the relationship between delivery mode and POP, there is a significant correlation between vaginal delivery and POP. PMID: 30391992 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Rosmarinic Acid Combined with Adriamycin Induces Apoptosis by Triggering Mitochondria-Mediated Signaling Pathway in HepG2 and Bel-7402 Cells.
This study aimed to evaluate the anti-tumor effects of rosmarinic acid (RosA) combined with Adriamycin (ADM) on proliferation and apoptosis of hepatic carcinoma cell lines. MATERIAL AND METHODS Human HepG2 and Bel-7402 cells were treated with RosA and ADM and divided into HepG2 or Bel-7402, 25 μg/ml, 50 μg/m, and 100 μg/ml RosA+0.4 μg/ml ADM groups, respectively. The Cell Counting Kit-8 (CCK-8) assay was used to evaluate cell viability. Immunohistochemistry assay was used to examine B cell lymphoma-2 (Bcl-2) and Bcl-2-associated X (Bax) expression. Cell cycle analysis was used to detect cell cycle distribution....
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression of the CD59 Glycoprotein Precursor is Upregulated in an Estrogen Receptor-alpha (ER- α)-Negative and a Tamoxifen-Resistant Breast Cancer Cell Line In Vitro.
CONCLUSIONS In summary, our results proposed a candidate biomarker for predicting TAM resistance in ERa-positive breast cancer via targeting CD59, therefore it could be a novel therapeutic option. PMID: 30391994 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression of NLPR3 in Psoriasis Is Associated with Enhancement of Interleukin-1 β and Caspase-1.
CONCLUSIONS NLPR3 may prove to be an important therapeutic target for psoriasis. PMID: 30393369 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Tangshen Formula Treatment for Diabetic Kidney Disease by Inhibiting Racgap1-stata5-Mediated Cell Proliferation and Restoring miR-669j-Arntl-Related Circadian Rhythm.
CONCLUSIONS TSF may be effective for DKD by inhibiting Racgap1-stata5-mediated cell proliferation and restoring miR-669j-Arntl-related circadian rhythm. PMID: 30394366 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Cardiovascular Risk and Neurocognitive Assessment in Young Adults and Their Relationship to Body Adiposity.
Authors: Habib SS, Bashir S, Iqbal M, Abdelaziz GM, Alyahya R, Alzahrani GK, Alangari SI, Alrayes NA, Alkahtani DS, Alonso-Alonso M Abstract BACKGROUND We assessed body composition, adiposity, cardiovascular risk, and cognitive functions in healthy young adult females and investigated the possible correlation between neurocognitive decline, adiposity, and cardiovascular risk markers. MATERIAL AND METHODS This cross-sectional study was conducted on 83 healthy, young adult, Saudi women (age 19-23 years). Subjects were classified into group (A) with 19 non-obese subjects and negative family history (FH) of cardiovascu...
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Value of Older Donors' Klotho Level in Predicting Recipients' Short-Term Renal Function.
CONCLUSIONS Klotho level, which decreases with age, may be a potential predictor of short-term renal function, especially for grafts from older donors. PMID: 30396199 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Comprehensive Analysis of Long Noncoding RNAs and Messenger RNAs Expression Profiles in Patients with Marjolin Ulcer.
CONCLUSIONS Taken together, our study implied the aberrant expression of lncRNAs may play an important role in the pathogenesis and development of MU, and the exact mechanism warrants further investigation. PMID: 30385735 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of RSC96 Schwann Cell-Derived Exosomes on Proliferation, Senescence, and Apoptosis of Dorsal Root Ganglion Cells In Vitro.
CONCLUSIONS An in vitro model of DRG cell injury induced by CMS, showed that RSC96 Schwann cell-derived exosomes had a protective effect. The effects of Schwann cell-derived exosomes on peripheral nerve injury, including in stress urinary incontinence, require future in vivo studies. PMID: 30387453 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis.
CONCLUSIONS The putative mechanism behind the metastasis-limiting effects of DHC may involve the suppression of Akt/GSK-3β and inhibition of MMP-2 and MMP-9 in lung cancer cells. PMID: 30388099 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Interleukin-22 Promotes Osteosarcoma Cell Proliferation and Invasion via STAT3 Activation.
CONCLUSIONS These results suggest that IL-22 promotes OS cells proliferation and invasion and its effect is mediated by activation of the STAT3 pathway. These findings demonstrate that IL-22 may serve as a promising molecular biomarker for diagnosis and therapy for OS patients. PMID: 30381753 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Pain Prevalence and Pain Management in a Chinese Hospital.
CONCLUSIONS The prevalence of pain is higher than the abnormality of the 4 traditional vital signs in a Chinese hospital. Although pain management has broadly improved, more patient education is necessary. PMID: 30382075 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

CBX8 and CD96 Are Important Prognostic Biomarkers of Colorectal Cancer.
CONCLUSIONS Through combined analysis of gene and isoform expression profiles, we identified several potential biomarkers that may play an important role in the development of CRC and could be helpful in its early diagnosis and treatment. PMID: 30383736 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression of Micro-RNA-492 (MiR-492) in Human Cervical Cancer Cell Lines is Upregulated by Transfection with Wild-Type P53, Irradiation, and 5-Fluorouracil Treatment In Vitro.
CONCLUSIONS In cervical cancer cells, p53 activated miR-492 expression transcriptionally. PMID: 30374014 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Behavioral and Emotional Problems in Early-Treated Brazilian Children and Adolescents with Phenylketonuria.
CONCLUSIONS Our findings indicate a significant prevalence of parents' complaints of attention problems and hyperactivity in non-adherent to treatment and intellectually low performing patients with PKU. PMID: 30375370 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Serum Levels of Androgen-Associated Hormones Are Correlated with Curative Effect in Androgenic Alopecia in Young Men.
Authors: Zhang Y, Xu J, Jing J, Wu X, Lv Z Abstract BACKGROUND Androgenic alopecia (AGA) is the most common type of hair loss in men. However, the pathogenesis is not yet fully understood and therapeutic approaches are limited. This retrospective study investigated the association between levels of androgen-associated hormones and curative effect in androgenic alopecia in young male AGA patients. MATERIAL AND METHODS By using chemiluminescence immunoassay, serum levels of androgens and upstream regulated hormones were measured in 178 young male patients with AGA and in 61 normal controls before therapy, 1 and 2 wee...
Source: Medical Science Monitor - November 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Marginal Fits of Crown Substructure Designs in Implant-Supported Abutments.
CONCLUSIONS The marginal gap of the substructures obtained using the direct metal laser sintering method was not significantly different from the change in marginal gap of other metal substructures (p>0.05). PMID: 30377289 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Bispectral Index Monitoring During Anesthesia Promotes Early Postoperative Recovery of Cognitive Function and Reduces Acute Delirium in Elderly Patients with Colon Carcinoma: A Prospective Controlled Study using the Attention Network Test.
This study aimed to evaluate the effects of BIS monitoring during surgery for resection of colon carcinoma in elderly patients using the Attention Network Test (ANT) to study alerting, orienting, and executive functions, and the Confusion Assessment Method (CAM). MATERIAL AND METHODS Eighty-one patients (65-75 years) underwent radical surgery for colon carcinoma with general intravenous anesthesia, propofol (6-8 mg/kg/h), vecuronium (0.03-0.05 mg/kg/min), and remifentanil (0.1-0.2 μg/kg/min). The BIS group (n=41) underwent adjustment of anesthesia to maintain a BIS value between 40-60; the non-BIS group (N=40) underwent...
Source: Medical Science Monitor - November 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Protective Effects of Methane-Rich Saline on Renal Ischemic-Reperfusion Injury in a Mouse Model.
CONCLUSIONS Our present study proved the protective effects of methane in RIR injury and, together with previous research, confirmed the multi-organ protective effects. This may help to translate methane application and develop its use in organ ischemic-reperfusion injury. PMID: 30379804 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 1, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Renal Function and Plasma Methotrexate Concentrations Predict Toxicities in Adults Receiving High-Dose Methotrexate.
Authors: Yang Y, Wang X, Tian J, Wang Z Abstract BACKGROUND Methotrexate (MTX) is an effective drug for the treatment of adult malignancies, but toxicity remains a significant problem. Toxic reactions may occur when patients use high-dose MTX (HD-MTX), but the correlation between its toxicity and concentration in adults is controversial. The purpose of this study was to examine the relationship between MTX concentration and renal function, as well as to assess toxic reactions to MTX in Chinese adults with acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). MATERIAL AND METHODS This retrospective stud...
Source: Medical Science Monitor - October 31, 2018 Category: Research Tags: Med Sci Monit Source Type: research