Doxorubicin-Induced Cancer Cell Senescence Shows a Time Delay Effect and Is Inhibited by Epithelial-Mesenchymal Transition (EMT).
CONCLUSIONS Our results suggested the existence of time delay effect in doxorubicin-induced senescence of HeLa cells, and epithelial- mesenchymal transition may resist doxorubicin-induced cell senescence. PMID: 31092810 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma.
CONCLUSIONS SEC61G expression may be a potential prognostic marker of poor survival, and a predictor of poor outcome to TMZ treatment and radiotherapy in GBM patients. PMID: 31094363 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Lung Large Cell Neuroendocrine Carcinoma: An Analysis of Patients from the Surveillance, Epidemiology, and End-Results (SEER) Database.
CONCLUSIONS LCNEC is a rare lung cancer subtype with a dismal prognosis. Primary surgical treatment has significant survival benefits, even for stage IV patients. The optimal treatment strategies for lung LCNEC require further investigation. PMID: 31095532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Primary Acute Angle-Closure Glaucoma: Three-Dimensional Reconstruction Imaging of Optic Nerve Heard Structure in Based on Optical Coherence Tomography (OCT).
CONCLUSIONS We used three-dimensional reconstruction to identify OCT images between glaucoma patients and the control group with significant differences. PMID: 31096262 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Study to Compare the Efficacy and Postoperative Outcome of Total Hip Arthroplasty with Internal Screw Fixation in Patients with Avascular Necrosis of the Femoral Head.
CONCLUSIONS Compared with closed reduction screw fixation, THA for AVN of the femoral head effectively reduced the length of hospital stay, time to recovery, and achieved an improved clinical outcome. PMID: 31097682 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria.
CONCLUSIONS The hyperoxaluria Drosophila models fed on 0.05% NaOx diet might be a useful tool to screen novel agents for the management of CaOx stones. K-HCA may be a promising agent for the prevention CaOx stones, with satisfying efficiency and acceptable safety. PMID: 31099342 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effectiveness and Renal Functions Safety of Treatments Used for Neonates with Patent Ductus Arteriosus: A Prospective Cohort Study.
The objective of this study was to test the hypothesis that indomethacin used in treating patent ductus arteriosus protects infants from renal dysfunction. MATERIAL AND METHODS This prospective cohort study assessed data on urine prostaglandin metabolites, urinary neutrophil gelatinase-associated lipocalin, and the renal functions of preterm infants with confirmed patent ductus arteriosus who had been injected with indomethacin (n=144, ID group) or acetaminophen (n=144, AP group). RESULTS A reduction of neutrophil gelatinase-associated lipocalin in urine samples was found in the ID group (993±48 µG/L vs. 103&p...
Source: Medical Science Monitor - May 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Obstructive Sleep Apnea-Hypopnea Syndrome on Serum Carcinoembryonic Antigen Levels in Patients with Type 2 Diabetes Mellitus.
Authors: Zhou J, Huang X, Jiang X Abstract BACKGROUND Type 2 diabetes mellitus (T2DM) is related to the serum carcinoembryonic antigen (CEA) level, which is used as a marker of colorectal cancer. Obstructive sleep apnea-hypopnea syndrome (OSAS) has been recently reported to have cancer-promoting effects. The aim of our study was to observe the effect of OSAS on serum levels of CEA in patients with T2DM. MATERIAL AND METHODS We enrolled 401 T2DM patients in this study. There were 244 patients with OSAS and 157 patients without OSAS. RESULTS The CEA level in T2DM patients with OSAS was higher than that in those without OSAS (p
Source: Medical Science Monitor - May 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of the Effects of Indobufen and Warfarin in a Rat Model of Adenine-Induced Chronic Kidney Disease.
This study aimed to compare the effects of indobufen, a new antiplatelet agent, with warfarin in a rat model of adenine-induced CKD. MATERIAL AND METHODS Forty-eight male Wistar rats were treated with intragastric adenine to create the rat model of CKD and were divided into four groups: an untreated control group (N=12), a group treated with dimethyl sulfoxide (DMSO) (N=12), a group treated with indobufen, (N=12) and a group treated with warfarin (N-12). Treatment was given for 4 weeks and 8 weeks. Kidney histology was performed, and the degree of fibrosis was quantified using Masson trichrome staining. RESULTS In the rat ...
Source: Medical Science Monitor - May 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association of Hair Cortisol Concentration with Prevalence of Major Cardiovascular Risk Factors and Allostatic Load.
CONCLUSIONS The results of this study suggest that increased prevalence of traditional cardiovascular risk factors is associated with higher HCC. Also, both HCC and AL index might be appropriate markers for the evaluation of chronic stress level. PMID: 31086129 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Isolated Decompression for Transverse Sacral Fractures with Cauda Equina Syndrome.
CONCLUSIONS Isolated decompression can be considered for patients who present a stable sacrum with non-displaced fracture or an old fracture that shows fracture healing. Favorable pelvic outcomes and neurological recovery, along with acceptable stability, can be acquired. PMID: 31089068 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of the Volatile Oil of Cichorium Glandulosum Boiss et Huet and its Effects on Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
CONCLUSIONS GC-MS identified the components of the volatile oil of CG, which included citronellol. Treatment with volatile oil of CG reduced liver fibrosis in a rat model. PMID: 31089070 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract.
This study was conducted to investigate the effect of a diet supplemented with rumen-protected (RP) 5-hydroxytryptophan (5-HTP) on the pineal gland and intestinal tract MLT synthesis of sheep. MATERIAL AND METHODS Eighteen Kazakh sheep were assigned randomly to 3 diet groups: control group (CT, corn-soybean meal basal diet), CT+111 group (111 mg/kg BW RP 5-HTP), and CT+222 group (222 mg/kg BW RP 5-HTP). The gene expressions of aromatic amino acid decarboxylase (AADC), arylalkylamine N-acetyltransferase (AA-NAT), hydroxyindole-O-methyltransferase (HIOMT), monoamine oxidase A (MAOA), and the intermediates of MLT synthesis we...
Source: Medical Science Monitor - May 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review.
Authors: Tan Z Abstract d_abstr_R Gastric cancer is a common malignancy with a poor prognosis, and surgical treatment remains the first-line approach to treatment to provide a cure. Despite advances in surgical techniques, radiotherapy, chemotherapy, and neoadjuvant therapy, gastric cancer remains the second leading cause of cancer death worldwide. Although the 5-year survival rate of early gastric cancer can reach>90%, due to the low early diagnosis rate, most patients present with advanced-stage gastric cancer. Therefore, there has been increasing interest in improving surgical treatment of advanced gastric ca...
Source: Medical Science Monitor - May 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Peroral Endoscopic Myotomy with the Stag Beetle Knife (SB Knife): Feasibility and Follow-Up.
The objective of this study was to evaluate the efficacy and safety of the SB knife. MATERIAL AND METHODS A total of 71 patients undergoing POEM with the SB knife for esophageal achalasia were included. We used esophagography, manometry, esophagogastroduodenoscopy (EGD), and Eckardt score to assess the utility and safety. RESULTS All cases were completed for POEM. The incidence of adverse events during the operation were 2.8%; however, all cases were treated conservatively. There was a vast improvement in clinical symptoms and endoscopic findings. The average Eckardt score was 6.9 before and 0.6 at 1 year after POEM (p
Source: Medical Science Monitor - May 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Colon-Specific DNA Methylation-Regulated Gene Modules on Colorectal Cancer Patient Survival.
CONCLUSIONS The results of this study could open a new era and aid the development of novel therapeutic targets for the treatment of CRC patient. PMID: 31083646 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Autologous Breast Reconstruction with Transverse Rectus Abdominis Musculocutaneous (TRAM) or Deep Inferior Epigastric Perforator (DIEP) Flaps: An Analysis of the 100 Most Cited Articles.
Authors: Cai A, Suckau J, Arkudas A, Beier JP, Momeni A, Horch RE Abstract Post-mastectomy autologous reconstruction with abdominal tissue has evolved over the past 4 decades and is a common reconstructive modality today. To gain more insight into this evolution, we performed an analysis of the 100 most commonly cited articles focusing on autologous breast reconstruction with transverse rectus abdominis musculocutaneous (TRAM) or deep inferior epigastric perforator (DIEP) flaps. A review of the ISI Web of Knowledge database was performed. Only peer-reviewed articles in English were included for analysis. Articles w...
Source: Medical Science Monitor - May 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparative Study of the Effects of Customized 3D printed insole and Prefabricated Insole on Plantar Pressure and Comfort in Patients with Symptomatic Flatfoot.
This study investigated the effects of customized 3-dimensional (3D) printed insoles on pressure and comfort of the plantar foot in symptomatic flatfoot patients. MATERIAL AND METHODS Eighty patients with bilateral flatfoot participated in this study. At week 0, patients were randomly assigned into 1 of 2 groups. In the control group, the patients wore standardize shoes with prefabricated insoles; and in the experimental group the patients wore standardize shoes and customized insoles. The Footscan® system recorded peak pressure, peak force, and peak contact area in 10 areas of the sole at weeks 0 and at week 8. Patien...
Source: Medical Science Monitor - May 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

An Evaluation of Bone Mineral Density Using Cone Beam Computed Tomography in Patients with Ectodermal Dysplasia: A Retrospective Study at a Single Center in Turkey.
CONCLUSIONS In patients with ectodermal dysplasia, reduced BMD should be taken into consideration when planning surgical interventions involving bone tissue and when planning implant surgery. The results of this study may be of value in dentistry and other fields of medicine. PMID: 31079139 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 14, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Study of Hemodynamic Changes in Patients After Off-Pump Coronary Artery Bypass Graft Surgery Using Impedance Cardiography.
This study aimed to investigate the role of impedance cardiography (ICG) to evaluate hemodynamic changes in patients after off-pump coronary artery bypass graft (OPCABG) surgery. MATERIAL AND METHODS One-hundred and sixty patients who had undergone OPCAGB were enrolled and assessed using New York Heart Association NYHA functional class (II, II, and IV). ICG was used to measure the stroke volume (SV), stroke volume index (SI), cardiac output per minute (CO/min), cardiac index (CI), end-diastolic volume (EDV), pre-ejection period (PEP), left ventricular ejection time (LVET), systolic time ratio (STR), left ventricular ejecti...
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Therapeutic Efficacy Analysis of Talar Fracture Internal Fixation with Lateral Malleolar Osteotomy.
CONCLUSIONS Internal fixation of talar fractures with lateral malleolar osteotomy is a viable surgical approach to reduce injury to blood supply and maximize surgical exposure. PMID: 31074462 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Deubiquitinase Ovarian Tumor Domain-Containing Protein 5 (OTUD5) on Radiosensitivity of Cervical Cancer by Regulating the Ubiquitination of Akt and its Mechanism.
Authors: Yin F, He H, Zhang B, Zheng J, Wang M, Zhang M, Cui H Abstract BACKGROUND The aim of this study was to investigate the role of deubiquitinase [ovarian tumor domain-containing protein 5 (OTUD5)] in regulating Akt ubiquitination and its effect on the radiosensitivity of cervical cancer. MATERIAL AND METHODS Cervical cancer C33A cells were cultured, and then 2 groups of cells (overexpressed cells and silenced cells) were established by overexpressing and silencing OTUD5 gene. Next, quantitative polymerase chain reaction (qPCR) was employed to detect the expression level of OTUD5 in cells in each group. Co-imm...
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Reliability and Validity of Chinese-Version Borderline Personality Features Scale for Children.
This study was designed to assess the feasibility, reliability, and validity of the Chinese-version BPFS-C in a multi-school-based sample of Chinese children and adolescents. MATERIAL AND METHODS A total of 964 students were recruited from 3 senior high schools, 1 junior middle school, and 1 elementary school in Shenyang, Capital city of Liaoning Province, China. We used the Chinese-version BPFS-C, Children's Depression Inventory (CDI), McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD), University of California at Los Angeles (UCLA) Loneliness Scale, 12-item Aggression Questionnaire (AQ-12), the sub...
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Diagnostic Performance of Perfusion Computed Tomography for Differentiating Lung Cancer from Benign Lesions: A Meta-Analysis.
CONCLUSIONS CT perfusion imaging is a valuable technique for the diagnosis of pulmonary nodules. Lung cancer had higher perfusion and permeability than benign lesions. The evidence suggests blood volume is the best surrogate marker for characterizing the blood supply, while permeability surface has a high specificity in quantifying the vascular permeability. PMID: 31077263 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer.
CONCLUSIONS In patients with colorectal cancer, CD8⁺LAG-3⁺ T cells showed more specific anti-tumor activity following cell culture in vitro, which supported the potential role for the LAG-3 immune checkpoint receptor in enriching tumor-specific T cells in patients with cancer. PMID: 31077581 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Therapeutic Effects of Sleeve Gastrectomy and Ileal Transposition on Type 2 Diabetes in a Non-Obese Rat Model by Regulating Blood Glucose and Reducing Ghrelin Levels.
This study aimed to investigate the effects of sleeve gastrectomy (SG) and ileal transposition (IT) surgery on the control of diabetes. MATERIAL AND METHODS Goto-Kakizaki rats were used to establish type 2 diabetes models and undergo SG or IT surgery. At 2 months post-surgery, insulin, glucose, triglycerides (TG), total cholesterol (TC), glucose tolerance, glucagon-like peptide-1 (GLP-1) levels, and insulin sensitivity were evaluated. RESULTS SG significantly shortened operative time and post-operative recovery time compared to IT surgery (P
Source: Medical Science Monitor - May 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Current Status of Functional Studies on Circular RNAs in Bladder Cancer and their Potential Role as Diagnostic and Prognostic Biomarkers: A Review.
Authors: Cong L, Yang Q, Hu C, Yu Q, Hao S, Li D Abstract d_abstr_R Worldwide, bladder cancer represents the ninth most common malignancy and is the 13th cause of cancer-associated death. Although surgery combined with chemotherapy and radiotherapy has improved patient outcomes, the prognosis remains poor for most patients with muscle-invasive bladder cancer. The exact mechanisms and critical regulators of bladder cancer remain unknown. Circular RNAs (circRNAs) are a distinct type of endogenous non-coding RNA. Recent studies have shown that circRNAs participate in many processes, including proliferation, invasion, ...
Source: Medical Science Monitor - May 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Parallelogram Effect of Degenerative Structures Around the Apical Vertebra in Patients with Adult Degenerative Scoliosis: The Influence of Asymmetric Degeneration and Diagonal Degeneration on the Severity of Deformity.
Authors: Sun XY, Kong C, Lu SB, Wang W, Cheng YZ, Sun SY, Guo MC, Ding JZ Abstract BACKGROUND This is the first published study assessing the parallelogram effect of degenerative structures around the apical vertebra. We evaluated the effect of degenerative structures around the apical vertebra and spinopelvic parameters on the severity of ADS. MATERIAL AND METHODS We retrospectively reviewed data on 144 patients with ADS. The coronal (coronal Cobb angle, CA) and sagittal (thoracic kyphosis, TK; sagittal vertical axis, SVA; pelvic incidence, PI; lumbar lordosis, LL; sacral slope, SS; pelvic tilt, PT) parameters, lu...
Source: Medical Science Monitor - May 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Use of the Bispectral Index to Predict Recovery of Consciousness in Patients with Spontaneous Intracerebral Hemorrhage After Surgical Hematoma Evacuation: A Prospective Cohort Study.
Authors: Yang YL, Zhang L, He X, Zhou YM, Chen GQ, Xu M, Zhou JX Abstract BACKGROUND Our study aimed to test the predictive value of the bispectral index (BIS) for the post-operational consciousness recovery in patients undergone hematoma evacuation due to spontaneous intracerebral hemorrhage (ICH). MATERIAL AND METHODS In this prospective cohort study, we enrolled adult spontaneous ICH patients after surgical hematoma evacuation who did not recover consciousness on the first postoperative day. After patient enrollment, the BIS was continuously monitored for 12 hours, and the motor response on the Glasgow Coma Scal...
Source: Medical Science Monitor - May 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Deletion Polymorphism of Angiotensin Converting Enzyme Gene is Associated with Left Ventricular Hypertrophy in Uighur Hypertension-Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Patients.
CONCLUSIONS D allele and DD genotype of ACE gene are possible genetic markers for the risk of LVH in Uighur but not Han hypertension-OSAHS patients. PMID: 31064975 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Application of a Novel Modification of the Microbond Test for Evaluation of Adhesive Bond Strength Between Fiber Posts and Dual-Cure Dental Resin Cement.
Authors: Maletin A, Markovic D, Neskovic I, Ramic B, Veljovic T, Ristic I Abstract BACKGROUND While several tests can be used in the laboratory evaluation of composite resin-based cement materials, the push-out test remains the most prevalent. Due to difficulties in sample preparation, as well as a highly complex procedure, we attempted to develop an alternative method for testing the bond strength of dental resin cement materials. MATERIAL AND METHODS Ninety-six experimental samples of 2 dual-cure resin cements and 1 fiber post system were prepared for the 2 testing procedures: the push-out test and the modified M...
Source: Medical Science Monitor - May 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Improving the Surgical Effect for Primary Liver Cancer with Intraoperative Fluorescence Navigation Compared with Intraoperative Ultrasound.
CONCLUSIONS FNT can improve the R0 resection rate, ensure a safe distance between tumor and cutting edge and can identify more new cancerous nodules compared to IOUS. Thus, FNT could improve the surgical treatment effect for primary liver cancer and hopefully further improve the prognosis of patients. PMID: 31067211 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Phosphorylated Glycogen Synthase Kinase-3 β (GSK-3β) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline.
CONCLUSIONS Our results show that GSK-3ß regulates the production of cytochrome C, Caspase-3, and Caspase-9 in STZ-induced rat brain and may therefore contribute to DM-caused cognitive dysfunction via inhibition of neural cell apoptosis. PMID: 31057171 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Dyslipidemia is a Risk Factor for the Incidence and Severity of Drug-Induced Liver Injury (DILI): A Retrospective Population-Based Study in China.
CONCLUSIONS Increased risk of the incidence of DILI was significantly associated with female gender and dyslipidemia, and the risk of developing severe DILI was associated with drinking alcohol and dyslipidemia. PMID: 31059494 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Low Maternal Dietary Folate Alters Retrotranspose by Methylation Regulation in Intrauterine Growth Retardation (IUGR) Fetuses in a Mouse Model.
CONCLUSIONS Maternal dietary folate deficiency impaired one-carbon metabolism, leading to global DNA and LINE-1 hypomethylation, and then increased retrotransposition in fetuses, which can lead to IUGR. PMID: 31061382 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Tripartite Motif-Containing Protein 59 (TRIM59) Promotes Epithelial Ovarian Cancer Progression via the Focal Adhesion Kinase(FAK)/AKT/Matrix Metalloproteinase (MMP) Pathway.
CONCLUSIONS TRIM59 is a biomarker for the prognosis of EOC. It is also oncogenic and a potential target for EOC therapy. PMID: 31062766 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression of Protein 4.1 Family in Breast Cancer: Database Mining for 4.1 Family Members in Malignancies.
CONCLUSIONS These results indicate that the protein 4.1 family can be regarded as novel biomarkers and potential therapeutic targets for BC. Further research is needed to explore the detailed biological functions. PMID: 31063460 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Mirror Therapy Using Gesture Recognition for Upper Limb Function, Neck Discomfort, and Quality of Life After Chronic Stroke: A Single-Blind Randomized Controlled Trial.
CONCLUSIONS We found that GR device-based mirror therapy is an intervention that improves upper-extremity function, neck discomfort, and quality of life in patients with chronic stroke. PMID: 31050660 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Chemical Composition of East Asian Invasive Knotweeds, their Cytotoxicity and Antimicrobial Efficacy Against Cariogenic Pathogens: An In-Vitro Study.
CONCLUSIONS The results indicate that the R. japonica acetone extract can be considered as a natural, antimicrobial agent for caries control. PMID: 31053701 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Plasma Cold-Inducible RNA-Binding Protein Predicts Lung Dysfunction After Cardiovascular Surgery Following Cardiopulmonary Bypass: A Prospective Observational Study.
CONCLUSIONS The length of CPB time contributed to the upregulation of CIRP in patients who received cardiovascular surgery with CPB. CIRP levels could serve as a biomarker to predict the onset of lung injury induced by cardiovascular surgery. PMID: 31054221 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Actinin-4 as a Diagnostic Biomarker in Serum of Breast Cancer Patients.
CONCLUSIONS ACTN4 in serum can serve as a clinical predictor in the diagnosis or prediction of clinical outcomes of patients with BC. PMID: 31054253 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Study of Atrial Fibrillation Following Cavotricuspid Isthmus Ablation for Atrial Flutter.
CONCLUSIONS Following cavotricuspid isthmus ablation for atrial flutter, recurrence of atrial flutter was found in 15% of cases, and asymptomatic AF occurred in 30%. These findings have implications for the use of post-ablation oral anticoagulation treatment, which is often discontinued following ablation therapy and before patient follow-up. PMID: 31055590 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Delayed Contrast Enhancement in Magnetic Resonance Imaging and Vascular Morphology of Primary Diffuse Large B-Cell Lymphoma (DLBCL) of the Central Nervous System (CNS): A Retrospective Study.
CONCLUSIONS In primary DLBCL of the CNS, delayed imaging enhancement on MRI may be due to reduced neovascularization and vascular infiltration by lymphoma cells. PMID: 31055591 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Combined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis.
CONCLUSIONS Although levels of trimethylamine N-oxide were higher in ulcerative colitis patients, they did not achieve statistical significance in active ulcerative colitis and inactive ulcerative colitis groups. Sphingosine 1-phosphate was increased in ulcerative colitis patients and there were several microbiota associated with it. Although further study is still needed, sphingosine 1-phosphate will probably become a new target for treatment of ulcerative colitis. PMID: 31055592 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer's Disease.
Authors: Jiang L, Dong H, Cao H, Ji X, Luan S, Liu J Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid peptide 1-42 and phosphorylation of tau protein in the brain. Thus far, the transfer mechanism of these cytotoxic proteins between nerve cells remains unclear. Recent studies have shown that nanoscale extracellular vesicles (exosomes) originating from cells may play important roles in this transfer process. In addition, several genetic materials and proteins are also involved in intercellular communication by the secretion of the exosomes. That p...
Source: Medical Science Monitor - May 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Higher Expression of Linc00152 Promotes Bladder Cancer Proliferation and Metastasis by Activating the Wnt/ β-Catenin Signaling Pathway.
Higher Expression of Linc00152 Promotes Bladder Cancer Proliferation and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway. Med Sci Monit. 2019 May 01;25:3221-3230 Authors: Xian-Li T, Hong L, Hong Z, Yuan L, Jun-Yong D, Peng X, Yan-Ping S, Fang Y, Nan L Abstract BACKGROUND Recent studies have demonstrated that Linc00152 is highly expressed in multiple cancer types and its genes show tumor-promoting characteristics. However, the efficacy and biological mechanism of Linc00152 in bladder cancer remains unclear. MATERIAL AND METHODS We study investigated the relative expression and promoter...
Source: Medical Science Monitor - May 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Costunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9.
CONCLUSIONS Costunolide inhibited growth, apoptosis, ROS generation, and was associated with loss of mitochondrial membrane potential of OAW42-A multidrug-resistant ovarian cancer cells. PMID: 31043579 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression of TMEFF2 in Human Pancreatic Cancer Tissue and the Effects of TMEFF2 Knockdown on Cell, Proliferation, and Apoptosis in Human Pancreatic Cell Lines.
CONCLUSIONS In pancreatic cancer, TMEFF2 exerted as a tumor suppressor effect by regulating p-STAT3, MCL1, and VEGF via SHP-1. PMID: 31044775 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Postoperative Cognitive Decline After Cardiac Surgery: A Narrative Review of Current Knowledge in 2019.
Authors: Glumac S, Kardum G, Karanovic N Abstract The growing number of publications concerning postoperative cognitive decline (POCD) after cardiac surgery is indicative of the health-related and economic-related importance of this intriguing issue. Significantly, the reported POCD incidence over the years has remained steady due to various unresolved challenges regarding the examination of this multidisciplinary topic. In particular, a universally accepted POCD definition has not been established, and the pathogenesis is still vaguely understood. However, numerous recent studies have focused on the role of the in...
Source: Medical Science Monitor - May 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Sperm Cryopreservation for Male Cancer Patients: More than 10 Years of Experience, in Beijing China.
CONCLUSIONS The physician should make an effort to promote fertility preservation for male cancer patients in China. And patients with testicular cancer and leukemia require additional attention. PMID: 31048670 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research