Editorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-19 Pandemic
Med Sci Monit. 2021 Oct 18;27:e935123. doi: 10.12659/MSM.935123.ABSTRACTThe development and use of digital health technology have increased during the global COVID-19 pandemic. Artificial intelligence (AI)-powered digital tools have been increasingly used to diagnose and screen for SARS-CoV-2 infection. Digital technology, in the form of mobile phone applications (apps), has been adopted by several countries to track infected individuals as infection prevention and surveillance measures. Global best practice guidelines, technology approvals, and patient care models have only recently begun to catch up with the developments...
Source: Medical Science Monitor - October 18, 2021 Category: Research Authors: Dinah V Parums Source Type: research

Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons
CONCLUSIONS D1Rs mediate the GABAAR internalization induced by SS via a PKC-dependent manner and participate in the excitotoxic process of SGNs.PMID:34657931 | DOI:10.12659/MSM.933278 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 18, 2021 Category: Research Authors: Jiangyuan Qin Tingjia Wei Huiying Chen Xiaoyu Lin Danxue Qin Fangyu Wei Peiqiang Liu Wenhua Ye Jiping Su Source Type: research

White Matter Abnormalities in Traumatic Subarachnoid Hemorrhage: A Tract-Based Spatial Statistics Study
In this study, we examined abnormalities of white matter in isolated traumatic subarachnoid hemorrhage patients by applying tract-based spatial statistics. MATERIAL AND METHODS For this study, 10 isolated traumatic subarachnoid hemorrhage patients and 10 age- and sex-matched healthy control subjects were recruited. Fractional anisotropy data voxel-wise statistical analyses were conducted through the tract-based spatial statistics as implemented in the FMRIB Software Library. Depending on the intersection between the fractional anisotropy skeleton and the probabilistic white matter atlases of Johns Hopkins University, we ca...
Source: Medical Science Monitor - October 17, 2021 Category: Research Authors: Min Son Kim Min Jye Cho Jae Woon Kim Sung Ho Jang Source Type: research

Computed Tomography-Guided Radiofrequency Ablation of the Cervical Dorsal Root Ganglia in 27 Patients with Cervical and Occipital Postherpetic Neuralgia
Med Sci Monit. 2021 Oct 16;27:e932612. doi: 10.12659/MSM.932612.ABSTRACTBACKGROUND Postherpetic neuralgia (PHN) is a common complication of herpes zoster virus infection that is associated with intense pain. The present study aimed to investigate the use of computed tomography (CT)-guided radiofrequency ablation (RFA) of the cervical dorsal root ganglia (DRG) for treatment of cervical and occipital PHN in 27 patients at a single center. MATERIAL AND METHODS Twenty-seven patients with PHN in the cervical and/or occipital region were enrolled. After imaging the area of PHN in the patients, axial scanning was performed on the...
Source: Medical Science Monitor - October 16, 2021 Category: Research Authors: Huidan Lin Gang Cao Zhaodong Yang Guanjun Jin Bing Huang Changshun Huang Ming Yao Jinghan Shao Source Type: research

The Serum Metabolomics Study of Liver Failure and Artificial Liver Therapy Intervention
CONCLUSIONS A variety of differences in metabolites were found in each group, some of which revealed possible metabolic pathways leading to differences between groups. Blood metabolomics analysis has great potential in real-time dynamic monitoring of liver failure and evaluation of artificial liver therapy.PMID:34650025 | DOI:10.12659/MSM.930638 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 15, 2021 Category: Research Authors: Shipeng Huang Dali Hu Songsong Yuan Ying He Chengmu Li Ying Zhu Xiaoping Wu Source Type: research

Retracted: Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195
Med Sci Monit. 2021 Oct 14;27:e935056. doi: 10.12659/MSM.935056.ABSTRACTRetracted, due to breach of publishing guidelines, following the identification of non-original and manipulated figure images. Reference: Hui Zhang, Dong Zhou, Mingang Ying, Minyong Chen, Peng Chen, Zhaoshuo Chen, Fan Zhang: Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195. Med Sci Monit, 2016; 22: 4820-4829. DOI: 10.12659/MSM.898574.PMID:34645777 | DOI:10.12659/MSM.935056 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 14, 2021 Category: Research Authors: Hui Zhang Dong Zhou Mingang Ying Minyong Chen Peng Chen Zhaoshuo Chen Fan Zhang Source Type: research

A Retrospective Study of Postoperative Outcomes in 98 Patients Diagnosed with Gastrointestinal Stromal Tumor (GIST) of the Upper, Middle, and Lower Gastrointestinal Tract Between 2009 and 2019 at a Single Center in Poland
Med Sci Monit. 2021 Oct 14;27:e932809. doi: 10.12659/MSM.932809.ABSTRACTBACKGROUND Gastrointestinal stromal tumors (GISTs) arise in the smooth muscle pacemaker interstitial cells of Cajal, or similar cells. The aim of this retrospective study between 2009 and 2019 from a single center in Poland was to assess the selected prognostic factors (location, tumor size, mitotic index, body mass index (BMI), length of hospital stay, age, sex, and coexistent neoplasm) and to investigate postoperative outcomes in 98 patients with GIST of the upper, middle, and lower gastrointestinal tract. MATERIAL AND METHODS Between 2009 and 2019, ...
Source: Medical Science Monitor - October 14, 2021 Category: Research Authors: Patryk Zem ła Anna Stelmach Beata Jab łońska Dariusz Go łka S ławomir Mrowiec Source Type: research

Retracted: Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195
Med Sci Monit. 2021 Oct 14;27:e935056. doi: 10.12659/MSM.935056.ABSTRACTRetracted, due to breach of publishing guidelines, following the identification of non-original and manipulated figure images. Reference: Hui Zhang, Dong Zhou, Mingang Ying, Minyong Chen, Peng Chen, Zhaoshuo Chen, Fan Zhang: Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195. Med Sci Monit, 2016; 22: 4820-4829. DOI: 10.12659/MSM.898574.PMID:34645777 | DOI:10.12659/MSM.935056 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 14, 2021 Category: Research Authors: Hui Zhang Dong Zhou Mingang Ying Minyong Chen Peng Chen Zhaoshuo Chen Fan Zhang Source Type: research

A Retrospective Study of Postoperative Outcomes in 98 Patients Diagnosed with Gastrointestinal Stromal Tumor (GIST) of the Upper, Middle, and Lower Gastrointestinal Tract Between 2009 and 2019 at a Single Center in Poland
Med Sci Monit. 2021 Oct 14;27:e932809. doi: 10.12659/MSM.932809.ABSTRACTBACKGROUND Gastrointestinal stromal tumors (GISTs) arise in the smooth muscle pacemaker interstitial cells of Cajal, or similar cells. The aim of this retrospective study between 2009 and 2019 from a single center in Poland was to assess the selected prognostic factors (location, tumor size, mitotic index, body mass index (BMI), length of hospital stay, age, sex, and coexistent neoplasm) and to investigate postoperative outcomes in 98 patients with GIST of the upper, middle, and lower gastrointestinal tract. MATERIAL AND METHODS Between 2009 and 2019, ...
Source: Medical Science Monitor - October 14, 2021 Category: Research Authors: Patryk Zem ła Anna Stelmach Beata Jab łońska Dariusz Go łka S ławomir Mrowiec Source Type: research

Comparing the Traditional Versus Conservative Endodontic Access Cavities Design of the Maxillary First Molar: Using Cone-Beam Computed Tomography
CONCLUSIONS Compared with the traditional access cavity, creating a conservative access cavity was less invasive. Meanwhile, the access cavity should be limited to the central or near the central area of nine-rectangle-grid.PMID:34642292 | DOI:10.12659/MSM.932410 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 13, 2021 Category: Research Authors: Huachao Sui Bo Zhao Haidan Nie Xin Hao Feng Qiao Cuicui Sun Changyi Li Liwen Zhou Ligeng Wu Source Type: research

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review
Med Sci Monit. 2021 Oct 12;27:e930776. doi: 10.12659/MSM.930776.ABSTRACTDuring the coronavirus disease 2019 (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, patients presented with COVID-19 pneumonia of varying severity. The phenomenon of severe hypoxemia without signs of respiratory distress is also known as silent or hidden hypoxemia. Although silent hypoxemia is not unique to pneumonia due to SARS-CoV-2 infection, this phenomenon is now recognized to be associated with severe COVID-19 pneumonia. Proper management of critically ill patients is the key to reducing mortalit...
Source: Medical Science Monitor - October 12, 2021 Category: Research Authors: Lizhe Guo Zhaosheng Jin Tong J Gan E Wang Source Type: research

Comparison of 2 Peripheral Nerve Blocks Techniques for Functional Recovery and Postoperative Pain Management After Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Trial
CONCLUSIONS The distal femoral triangle and distal adductor canal blocks resulted in significantly better motor function at the first 3 and 6 h after total knee arthroplasty. At 24 h after surgery, rescue opioid doses in the femoral nerve block group were significantly higher.PMID:34629461 | DOI:10.12659/MSM.932848 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 11, 2021 Category: Research Authors: Inna Jaremko Karina Luka ševič Šarūnas Tarasevičius Linas Zeniauskas Andrius Macas Ar ūnas Gelmanas Source Type: research

Editorial: Multisystem Inflammatory Syndrome in Adults (MIS-A) and the Spectrum of COVID-19
Med Sci Monit. 2021 Oct 11;27:e935005. doi: 10.12659/MSM.935005.ABSTRACTRecent studies on the pathogenesis and clinical spectrum of human disease following infection with the new human pathogen, SARS-CoV-2, have identified the varied presentations and sequelae of COVID-19. Acute 'cytokine storm' in severe COVID-19 results in multiorgan damage due to vascular hyperpermeability, edema, and hypercoagulation. The long-term consequences of infection from SARS-CoV-2 include long COVID. or post-COVID syndrome, and multisystem inflammatory syndrome in children (MIS-C). Several case reports of multisystem inflammatory syndrome in a...
Source: Medical Science Monitor - October 11, 2021 Category: Research Authors: Dinah V Parums Source Type: research

Comparison of 2 Peripheral Nerve Blocks Techniques for Functional Recovery and Postoperative Pain Management After Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Trial
CONCLUSIONS The distal femoral triangle and distal adductor canal blocks resulted in significantly better motor function at the first 3 and 6 h after total knee arthroplasty. At 24 h after surgery, rescue opioid doses in the femoral nerve block group were significantly higher.PMID:34629461 | DOI:10.12659/MSM.932848 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 11, 2021 Category: Research Authors: Inna Jaremko Karina Luka ševič Šarūnas Tarasevičius Linas Zeniauskas Andrius Macas Ar ūnas Gelmanas Source Type: research

Editorial: Multisystem Inflammatory Syndrome in Adults (MIS-A) and the Spectrum of COVID-19
Med Sci Monit. 2021 Oct 11;27:e935005. doi: 10.12659/MSM.935005.ABSTRACTRecent studies on the pathogenesis and clinical spectrum of human disease following infection with the new human pathogen, SARS-CoV-2, have identified the varied presentations and sequelae of COVID-19. Acute 'cytokine storm' in severe COVID-19 results in multiorgan damage due to vascular hyperpermeability, edema, and hypercoagulation. The long-term consequences of infection from SARS-CoV-2 include long COVID. or post-COVID syndrome, and multisystem inflammatory syndrome in children (MIS-C). Several case reports of multisystem inflammatory syndrome in a...
Source: Medical Science Monitor - October 11, 2021 Category: Research Authors: Dinah V Parums Source Type: research

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model
CONCLUSIONS MB is protective against acute seizure in SE. This beneficial effect may be at least partially related to its potent antioxidant ability and influence on Glu level.PMID:34628461 | DOI:10.12659/MSM.933469 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 10, 2021 Category: Research Authors: Yong-Feng Wang Yan Luo Gao-Lei Hou Rui-Jing He Hao-Yun Zhang Yan-Li Yi Ying Zhang Zhi-Qiang Cui Source Type: research

A Review of Phosphocreatine 3 Kinase δ Subtype (PI3Kδ) and Its Inhibitors in Malignancy
Med Sci Monit. 2021 Oct 9;27:e932772. doi: 10.12659/MSM.932772.ABSTRACTMost cancer deaths are caused by metastasis. The phosphocreatine 3- kinase (PI3K) family includes the I-III classes, with class I divided into 4 subtypes (alpha, ß, γ, delta); and PI3K signaling participates in the regulatory processes of cell proliferation, differentiation, apoptosis, and glucose transport. Moreover, PI3Ks are modulators of cellular membrane lipids involved in signaling and trafficking events. The PI3Kdelta isoform (PI3Kdelta), which is not only specifically expressed in hematopoietic cells, but also in different tumor cell...
Source: Medical Science Monitor - October 9, 2021 Category: Research Authors: Qiong Xiang Shuai Dong Xian-Hui Li Source Type: research

Left Main Bronchus Stenosis Lesion, Neutrophil Count, and Platelet Count Are Predictors of Post-Tuberculosis Bronchomalacia
Med Sci Monit. 2021 Oct 8;27:e931779. doi: 10.12659/MSM.931779.ABSTRACTBACKGROUND Post-tuberculosis bronchomalacia (PTBM) is one of the main conditions occurring in patients after tracheobronchial tuberculosis (TBTB), and is also associated with the recurrence of symptoms. The present study aimed to investigate the predictors of PTBM in patients who had been undergoing appropriate TB treatment. MATERIAL AND METHODS Clinical data of 104 patients with symptomatic airway stenosis after TBTB between January 01, 2019 and June 31, 2020 were recorded and analyzed. The association between baseline clinical characteristics, laborat...
Source: Medical Science Monitor - October 8, 2021 Category: Research Authors: Yongchang Wu Yishi Li Yang Bai Jinyue Jiang Xiaohui Wang Shuliang Guo Source Type: research

Use of a Percutaneous Needle Release Technique for Trigger Thumb: A Retrospective Study of 11 Patients from a Single Center
This report describes a modified percutaneous needle release and an evaluation of its clinical efficacy to treat trigger thumb. MATERIAL AND METHODS Trigger thumb of 11 patients was released percutaneously using a specially designed needle (0.8×100 mm) with a planus tip. Complete release was ensured when no more grating sound was heard and the needle moved freely at the tip. Pain-related functional score was evaluated preoperatively and at 3 months postoperatively. Resolution of Notta's node, triggered or locked, Quinnell's criteria, and patient satisfaction were also assessed at 3 months after the operation. RESULTS...
Source: Medical Science Monitor - October 7, 2021 Category: Research Authors: Xianjie Sun Haidong Wang Xingen Zhang Bangjian He Source Type: research

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT Results
CONCLUSIONS The ETLC score is helpful for efficiently identifying patients with suspected COVID-19.PMID:34611122 | DOI:10.12659/MSM.931467 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 6, 2021 Category: Research Authors: Wanming Hao Long Zhao Xinjuan Yu Song Wu Weifeng Xie Ning Wang Weihong Lv Akshay Sood Shuguang Leng Yongchun Li Qing Sun Jun Guan Wei Han Source Type: research

miRNA Profiling of Hungarian Regressive Wilms' Tumor Formalin-Fixed Paraffin-Embedded (FFPE) Samples by Quantitative Real-Time Polymerase Chain Reaction (RT-PCR)
CONCLUSIONS We conclude that a downregulation of miR-184, miR-194-5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample. In most of our FFPE samples aged up to 9 years, RNA extraction provided miRNA with quantity and quality sufficient for qRT-PCR-based analysis, emphasizing the relevance of pathological archives as miRNA sources in future studies.PMID:34608109 | DOI:10.12659/MSM.932731 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 5, 2021 Category: Research Authors: Gergely Bugly ó Zs ófia Magyar Éva Romicsné Görbe Rita B ánusz Monika Cs óka Tam ás Micsik M árta Mezei Jaxi Ayman Shawky Yani P éter Varga Zolt án Sápi B álint Nagy Source Type: research

A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in 89 Patients Who Underwent 3-Year Follow-Up
Med Sci Monit. 2021 Oct 4;27:e933809. doi: 10.12659/MSM.933809.ABSTRACTBACKGROUND Proximal contact loss (PCL) is very common between implant-fixed prostheses (IFPs) and adjacent teeth and leads to a high incidence of food impaction. Our aim was to determine if the mesio-distal adjustable (MDA) crown prostheses introduced in this study could easily establish new contacts intraorally without the intervention of prostheses retrieval. MATERIAL AND METHODS The MDA crown requires casting in the inlay framework at the proximal contact area. If PCL occurred, the resin in the inlay framework could be easily removed and refilled cha...
Source: Medical Science Monitor - October 4, 2021 Category: Research Authors: Qiyue Chen Yong Shi Zhaoqiang Zhang Guangbao Song Source Type: research

Editorial: A Decline in Influenza During the COVID-19 Pandemic and the Emergence of Potential Epidemic and Pandemic Influenza Viruses
Med Sci Monit. 2021 Oct 4;27:e934949. doi: 10.12659/MSM.934949.ABSTRACTThere have been five viral pandemics in the past century, four were due to influenza, and the ongoing COVID-19 pandemic is due to SARS-CoV-2 infection. During the COVID-19 pandemic, there has been a 99% global reduction in the diagnosis of influenza. Also, from 2020, global mortality rates from influenza fell to record levels during the influenza seasons in the southern and northern hemispheres. However, as social restrictions become lifted and the winter season begins in the northern hemisphere, it is expected that influenza will re-emerge. The World H...
Source: Medical Science Monitor - October 4, 2021 Category: Research Authors: Dinah V Parums Source Type: research

A Single-Center Study of a Resin Inlay Dental Implant-Fixed Prosthesis for Closing Proximal Contact Loss in 89 Patients Who Underwent 3-Year Follow-Up
Med Sci Monit. 2021 Oct 4;27:e933809. doi: 10.12659/MSM.933809.ABSTRACTBACKGROUND Proximal contact loss (PCL) is very common between implant-fixed prostheses (IFPs) and adjacent teeth and leads to a high incidence of food impaction. Our aim was to determine if the mesio-distal adjustable (MDA) crown prostheses introduced in this study could easily establish new contacts intraorally without the intervention of prostheses retrieval. MATERIAL AND METHODS The MDA crown requires casting in the inlay framework at the proximal contact area. If PCL occurred, the resin in the inlay framework could be easily removed and refilled cha...
Source: Medical Science Monitor - October 4, 2021 Category: Research Authors: Qiyue Chen Yong Shi Zhaoqiang Zhang Guangbao Song Source Type: research

Editorial: A Decline in Influenza During the COVID-19 Pandemic and the Emergence of Potential Epidemic and Pandemic Influenza Viruses
Med Sci Monit. 2021 Oct 4;27:e934949. doi: 10.12659/MSM.934949.ABSTRACTThere have been five viral pandemics in the past century, four were due to influenza, and the ongoing COVID-19 pandemic is due to SARS-CoV-2 infection. During the COVID-19 pandemic, there has been a 99% global reduction in the diagnosis of influenza. Also, from 2020, global mortality rates from influenza fell to record levels during the influenza seasons in the southern and northern hemispheres. However, as social restrictions become lifted and the winter season begins in the northern hemisphere, it is expected that influenza will re-emerge. The World H...
Source: Medical Science Monitor - October 4, 2021 Category: Research Authors: Dinah V Parums Source Type: research

Assessment of Color Stainability of Computer-Aided Design and Computer-Aided Manufacturing (CAD/CAM) Ceramic Materials After Hot and Cold Coffee Immersion at Different Time Intervals
CONCLUSIONS Coffee caused staining and contamination of ceramic material. Values of ΔE₀₀ for tested ceramic materials were significantly different but were within the clinically acceptable range. Polished specimens showed higher staining; therefore, we highly recommend re-glazing of ceramic restorations to maintain color stability.PMID:34601487 | DOI:10.12659/MSM.932745 (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 3, 2021 Category: Research Authors: Hafiz A Adawi Mohammed M Al Mialeem Nasser M Al Ahmari Mansoor Shariff Mohammed A Qahhar Sultan M H Muharraq Nabiel A Alghazali Source Type: research

Preoperative Alkaline Phosphatase-to-Cholesterol Ratio as a Predictor of Overall Survival in Pancreatic Ductal Adenocarcinoma Patients Undergoing Radical Pancreaticoduodenectomy
Med Sci Monit. 2021 Oct 2;27:e931868. doi: 10.12659/MSM.931868.ABSTRACTBACKGROUND The value of alkaline phosphatase and cholesterol for predicting overall survival (OS) in cancer patients has been previously studied. However, the predictive value of these variables in patients with pancreatic ductal adenocarcinoma (PDAC) was limited. Hence, we conducted this study to investigate the prognostic value of the alkaline phosphatase-to-cholesterol ratio (ACR) in patients undergoing radical pancreaticoduodenectomy (PD) for PDAC. MATERIAL AND METHODS A total of 102 PDAC patients undergoing radical PD at the Cancer Hospital Chinese...
Source: Medical Science Monitor - October 2, 2021 Category: Research Authors: Guotong Qiu Lipeng Zhang Zongting Gu Hu Ren Yongxing Du Zongze Li Chengfeng Wang Source Type: research

Comparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maximum Knee Flexion in the Lateral Decubitus Position with Routine Knee Positioning
This study assessed magnetic resonance imaging (MRI) of acute and chronic partial anterior cruciate ligament (ACL) tears using maximum knee flexion in the lateral decubitus position compared with routine knee positioning in 204 patients at a single center. MATERIAL AND METHODS Based on the time interval from injury to MRI examination, the 204 patients in this study were divided into 3 groups: subacute (6 weeks to 3 months), intermediate (3 months to 1 year), and chronic (>1 year). All patients received both routine MRI (MRI R) and maximum knee flexion in the lateral decubitus position MRI (MRI S) examination, followed b...
Source: Medical Science Monitor - October 1, 2021 Category: Research Authors: Zijun Xu Yichao Chen Jianghua Zhu Lin Zhang Peng Wu Source Type: research

Prospective Study on the Postoperative Use of Levosimendan After Conventional Heart Valve Replacement
Med Sci Monit. 2021 Sep 30;27:e932001. doi: 10.12659/MSM.932001.ABSTRACTBACKGROUND The aim of this study was to explore the effect of levosimendan in patients after heart valve replacement and its influence on postoperative recovery. MATERIAL AND METHODS This prospective study included 185 patients with valvular diseases undergoing conventional valve replacement. Patients were divided into 2 groups using a random number table before surgery. Patients in the levosimendan group were administrated levosimendan intravenous infusion immediately after entering the Intensive Care Unit (ICU). The left ventricular ejection fraction...
Source: Medical Science Monitor - September 30, 2021 Category: Research Authors: Wei Sheng Hui Qiao Zhaozhuo Niu Tianyi Wang Haoyou Li Wenfeng Zhang Jiantao Wu Xiao Lv Source Type: research

Identification of Risk Factors for Intraoperative Acquired Pressure Injury in Patients Undergoing Neurosurgery: A Retrospective Single-Center Study
Med Sci Monit. 2021 Sep 29;27:e932340. doi: 10.12659/MSM.932340.ABSTRACTBACKGROUND Risk factors for intraoperative acquired pressure injury (IAPI) in patients undergoing various surgical procedures have been described in previous studies. However, whether risk factors for IAPI in patients undergoing neurosurgery differ remains unknown. The aim of the present study was to explore independent risk factors for IAPI in patients undergoing neurosurgery. MATERIAL AND METHODS Data from 465 patients who underwent neurosurgery between October 2017and December 2018 and who were at high risk of IAPIs were retrospectively analyzed. In...
Source: Medical Science Monitor - September 29, 2021 Category: Research Authors: Ying Wu Zhiqun Jiang Shuzhen Huang Bin Shi Chan Wang Yu Zeng Source Type: research

Erratum: Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma
Med Sci Monit. 2021 Sep 29;27:e934874. doi: 10.12659/MSM.934874.ABSTRACTThere was an error in Figure 4. The correct Figure 4 is provided below. The picture error would not affect the conclusion of the paper. Reference: Dong Ouyang, Ruyi Li, Yaxian Li, Xueqiong Zhu. Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma. Med Sci Monit 2019; 25:7998-8010. DOI: 10.12659/MSM.915798.PMID:34584064 | DOI:10.12659/MSM.934874 (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 29, 2021 Category: Research Authors: Dong Ouyang Ruyi Li Yaxian Li Xueqiong Zhu Source Type: research

Automated Boluses and Delayed-Start Timers Prolong Perineural Local Anesthetic Infusions and Analgesia Following Ankle and Wrist Orthopedic Surgery: A Case-Control Series
CONCLUSIONS For infraclavicular and popliteal sciatic catheters, automated boluses may provide a longer duration of analgesia than continuous infusions following painful hand and ankle surgeries, respectively.PMID:34580272 | DOI:10.12659/MSM.933190 (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 28, 2021 Category: Research Authors: John J Finneran Iv Paola Baskin William T Kent Eric R Hentzen Alexandra K Schwartz Brian M Ilfeld Source Type: research

Postoperative Neutrophil-to-Lymphocyte Ratio Is Associated with Mortality in Adult Patients After Cardiopulmonary Bypass Surgery: A Cohort Study
This study incorporates data from the MIMIC III database, which includes more than 50 000 critically ill patients. The variable of interest was postoperative NLR. The primary outcome was 30-day mortality and the secondary outcomes were 90-day mortality, length of intensive care unit stay, and length of hospital stay. was 30-day mortality, the secondary outcome was 90-day mortality, length of hospital stay and length of ICU stay. RESULTS We enrolled 575 CPB patients. The ROC curve for the postoperative NLR to estimate mortality was 0.741 (95% confidence interval [CI]: 0.636-0.847, P
Source: Medical Science Monitor - September 27, 2021 Category: Research Authors: Yanhong Zhu Wenyong Peng Shuai Zhen Xiaofeng Jiang Source Type: research

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)
Med Sci Monit. 2021 Sep 27;27:e934854. doi: 10.12659/MSM.934854.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has affected the number of completed clinical trials, particularly in oncology. Between 80-85% of all lung cancers are non-small cell lung cancer (NSCLC), and of these, between 2-3% have an EGFR exon 20 insertion, which is associated with increased cell proliferation, metastasis, and a lack of response to chemotherapy and epidermal growth factor receptor (EGFR) inhibitors. Until this year, there were no available targeted therapies for advanced NSCLC with this genetic subtype. However, in May 2021, the U...
Source: Medical Science Monitor - September 27, 2021 Category: Research Authors: Dinah V Parums Source Type: research

Postoperative Neutrophil-to-Lymphocyte Ratio Is Associated with Mortality in Adult Patients After Cardiopulmonary Bypass Surgery: A Cohort Study
This study incorporates data from the MIMIC III database, which includes more than 50 000 critically ill patients. The variable of interest was postoperative NLR. The primary outcome was 30-day mortality and the secondary outcomes were 90-day mortality, length of intensive care unit stay, and length of hospital stay. was 30-day mortality, the secondary outcome was 90-day mortality, length of hospital stay and length of ICU stay. RESULTS We enrolled 575 CPB patients. The ROC curve for the postoperative NLR to estimate mortality was 0.741 (95% confidence interval [CI]: 0.636-0.847, P
Source: Medical Science Monitor - September 27, 2021 Category: Research Authors: Yanhong Zhu Wenyong Peng Shuai Zhen Xiaofeng Jiang Source Type: research

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic Monoclonal Antibody for Advanced Non-Small Cell Lung Cancer (NSCLC)
Med Sci Monit. 2021 Sep 27;27:e934854. doi: 10.12659/MSM.934854.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has affected the number of completed clinical trials, particularly in oncology. Between 80-85% of all lung cancers are non-small cell lung cancer (NSCLC), and of these, between 2-3% have an EGFR exon 20 insertion, which is associated with increased cell proliferation, metastasis, and a lack of response to chemotherapy and epidermal growth factor receptor (EGFR) inhibitors. Until this year, there were no available targeted therapies for advanced NSCLC with this genetic subtype. However, in May 2021, the U...
Source: Medical Science Monitor - September 27, 2021 Category: Research Authors: Dinah V Parums Source Type: research

Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors
CONCLUSIONS These results suggest that sevoflurane inhalation via the SIK3 pathway aggravates cognitive impairment after acute sleep deprivation and that propofol anesthesia reverses the effects of sleep deprivation by affecting modifications of tau protein.PMID:34564688 | DOI:10.12659/MSM.932422 (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 26, 2021 Category: Research Authors: Mengxi Shen Naqi Lian Chengcheng Song Chao Qin Yang Yu Yonghao Yu Source Type: research

Effectiveness of Bone Conduction Hearing Aids in Young Children with Congenital Aural Atresia and Microtia
CONCLUSIONS Our results confirm that bone conduction hearing aids provide an effective method of auditory rehabilitation for children with conductive and mixed hearing loss caused by microtia and atresia. Using bone conduction hearing aids in such children is crucial for proper hearing, speech, and language development.PMID:34561413 | DOI:10.12659/MSM.933915 (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 25, 2021 Category: Research Authors: Katarzyna Beata Cywka Bart łomiej Król Piotr Henryk Skar żyński Source Type: research