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Atrioventricular Conduction Delay Predicts Impaired Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction.
CONCLUSIONS Delayed AV conduction contributes to decreased exercise capacity in patients with HFREF and coexisting IVCD. PMID: 28819094 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Diffusion Kurtosis Imaging and Pathology in Spinal Cord Ischemia/Reperfusion Injury in Rabbits: A Case-Control Study.
Authors: Li D, Wang X Abstract BACKGROUND The aim of this study was to evaluate the application of diffusion kurtosis imaging (DKI) in spinal cord ischemia/reperfusion (SCI/R) injury and to explore its association with pathology. MATERIAL AND METHODS Japanese male long-eared rabbits were chosen and divided into 7 groups (8 rabbits in each group): control group (C group), sham-operation control group (S group), and 5 experimental groups (E-2 h group, E-24 h group, E-48 h group, E-7 d group, and E-14 d group). Tarlov scoring and immunohistochemical staining were used to assess hindlimb motor function and observe the ...
Source: Medical Science Monitor - August 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations.
CONCLUSIONS The improvement effect of apigenin on cognitive impairments after cerebral ischemia and reperfusion injury may involve multiple mechanisms, such as the inhibition of HDAC, induction of BDNF and Syn-I expression, and regulation of histone acetylation. PMID: 28821706 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Primary Culture of Rat Aortic Vascular Smooth Muscle Cells: A New Method.
CONCLUSIONS We have conquered the disadvantages in the previous primary culture methods and established a simple and reliable way to isolate and culture rat aortic VSMCs with high purity and stability. PMID: 28822209 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Preoperative Halo-Gravity Traction for Severe Thoracic Kyphoscoliosis Patients from Tibet: Radiographic Correction, Pulmonary Function Improvement, Nursing, and Complications.
This study investigated the outcomes of preoperative HGT as an adjunct treatment for severe thoracic kyphoscoliosis, its role in radiographic correction, and pulmonary function improvement, together with nursing strategy and incidence of complications. MATERIAL AND METHODS Eleven patients with a mean age of 18.8 years were retrospectively reviewed. Inclusion criteria were: patients with severe kyphoscoliosis (coronal Cobb angle and kyphosis angle ≥80°); duration of HGT ≥8 weeks; patients undergoing HGT for at least 12 h per day; traction weight no less than 40% of body weight; and patients not receiving physical ...
Source: Medical Science Monitor - August 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Left Univentricular Pacing by Rate-Adaptive Atrioventricular Delay in Treatment of Chronic Heart Failure.
Authors: Zhao L, Zhao L, Pu L, Hua B, Wang Y, Li S, Li Q, Guo T Abstract BACKGROUND Cardiac resynchronization therapy (CRT) is efficacious in the treatment of chronic heart failure (CHF); however, because it is non-physiological, some patients are unresponsive. The present study used rate-adaptive atrioventricular delay (RAAVD) to track the physiological atrioventricular delay and investigated the effects of left univentricular pacing on CRT. MATERIAL AND METHODS Patients with CHF fulfilling the indication of CRT Class I were categorized into a left univentricular pacing by RAAVD group and a standard biventricular ...
Source: Medical Science Monitor - August 19, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Role of MicroRNA-93 I in Pathogenesis of Left Ventricular Remodeling via Targeting Cyclin-D1.
CONCLUSIONS We showed that CCND1 is a direct target of miR-93, and the dysregulation of the miR-93/CCND1 signaling pathway is responsible for the development of ventricular remodeling. PMID: 28817550 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats.
CONCLUSIONS These results obtained at different dosages and long-term implantation provide solid data confirming the safety of long-term use of Cu-IUDs. However, the elevated leucocyte levels found in this study warrant further investigation. PMID: 28813370 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 17, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection.
Authors: Li K, Wang ZW, Hu Z, Ren Z, Hu X, Li L, Wu Z, Wu H, Li B, Huang J, Ren W, Xia J, Ruan Y Abstract BACKGROUND Type A AAD, a serious cardiovascular emergency requiring urgent surgery, is the most common and serious AAD. The aim of this study was to investigate the diagnostic value of ADAMTS1 and ADAMTS4 in patients with type A acute aortic dissection (AAD). MATERIAL AND METHODS Immunohistochemistry and qRT-PCR were used to evaluate the protein and mRNA expression levels of ADAMTS1 and ADAMTS4 in 14 type A acute aortic dissection (AAD) tissues and 10 control aortic tissues. Serum ADAMTS1 and ADAMTS4 expression...
Source: Medical Science Monitor - August 16, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Artificial Intelligence, DNA Mimicry, and Human Health.
Authors: Stefano GB, Kream RM Abstract The molecular evolution of genomic DNA across diverse plant and animal phyla involved dynamic registrations of sequence modifications to maintain existential homeostasis to increasingly complex patterns of environmental stressors. As an essential corollary, driver effects of positive evolutionary pressure are hypothesized to effect concerted modifications of genomic DNA sequences to meet expanded platforms of regulatory controls for successful implementation of advanced physiological requirements. It is also clearly apparent that preservation of updated registries of advantage...
Source: Medical Science Monitor - August 16, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Kaempferol Alleviates the Interleukin-1 β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB.
CONCLUSIONS Kaempferol significantly caused reduction in interleukin-1β-stimulated pro-inflammatory mediators in rat OA chondrocytes by inhibiting the NF-κB pathway. These results suggest that kaempferol had significant anti-inflammatory and anti-arthritis effects. Thus, kaempferol, as a novel therapeutic active agent, may prevent, stop, or retard the progression of OA. PMID: 28806392 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Function of NLRP3 in the Pathogenesis and Development of Diabetic Nephropathy.
CONCLUSIONS NLRP3 and high glucose activation may participate in the occurrence and development of DN by mediating the inflammatory response. PMID: 28798291 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Factors Associated with Benign Paroxysmal Positional Vertigo: A Chinese Case-Control Study.
Authors: Yuan J, Dai J, Li WA, Hu W Abstract BACKGROUND Benign paroxysmal positional vertigo (BPPV) is one of the most common and most successfully treated vestibular disorders. However, there is a lack of predictive factors for BPPV in clinical practice. We aimed to explore several possible predictive factors for BPPV in the Chinese population. MATERIAL AND METHODS We enrolled 240 patients with BPPV from Beijing Chaoyang Hospital between July 2013 and July 2016. Biochemical and hematological markers were obtained along with the history of cardiovascular and cerebrovascular diseases. RESULTS Serum uric acid (SUA) [...
Source: Medical Science Monitor - August 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Cardiotoxicity and Mechanism of Particulate Matter 2.5 (PM2.5) Exposure in Offspring Rats During Pregnancy.
Authors: Wang H, Peng X, Cao F, Wang Y, Shi H, Lin S, Zhong W, Sun J Abstract BACKGROUND The aim of this study was to investigate the cardiotoxicity and mechanism of particulate matter 2.5 (PM2.5) exposure on offspring rats during pregnancy. MATERIAL AND METHODS Wistar rats were used to establish a PM2.5 exposure animal model during pregnancy, and they were divided into a control group, a low-dose group, a middle-dose group, and a high-dose group according to PM2.5 exposure dose. The pathological changes of heart tissue, the rate of myocardial cell apoptosis, the levels of LDH, AST, and CM-KB in serum, and the diff...
Source: Medical Science Monitor - August 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Resistin-Like Molecule Beta (RELM- β) Regulates Proliferation of Human Diabetic Nephropathy Mesangial Cells via Mitogen-Activated Protein Kinases (MAPK) Signaling Pathway.
CONCLUSIONS The results provide evidence that RELM-b is a potential molecular target for the treatment of DN. PMID: 28801998 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Cancer-Associated Fibroblasts Autophagy Enhances Progression of Triple-Negative Breast Cancer Cells.
In this study, the growth effect of TNBC cells regulated by CAFs autophagy was evaluated. MATERIAL AND METHODS CAFs were obtained from invasive TNBC tumors and identified by Western blot and immunofluorescence staining assay. CAFs were co-cultured with TNBC cells, and migration and invasion were evaluated by Matrigel-coated Transwell and Transwell inserts. TNBC cells growth was detected by MTT assay, and epithelial-mesenchymal transition (EMT) regulated by CAFs was evaluated by Western blot assay. RESULTS CAFs were identified by the high expression of α-smooth muscle actin (α-SMA) protein. Autophagy-relevant Be...
Source: Medical Science Monitor - August 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Role of Epithelial Cell Transforming Sequence 2 (ECT2) in Predicting Prognosis of Osteosarcoma.
CONCLUSIONS ECT2 is an independent prognostic factor for osteosarcoma and it can upregulate the metastatic capacity of osteosarcoma cells. PMID: 28794404 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

The Effect of Lumbar Disc Herniation on Musculoskeletal Loadings in the Spinal Region During Level Walking and Stair Climbing.
CONCLUSIONS LDH patients exhibited different kinetic alternations during level walking and stair climbing. However, both adaptive strategies added extra burdens to the trunk system and further increased the risk for development of LDH. PMID: 28796755 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

High Prolactin Level as a Predictor of Vasospasm in Aneurysmal Subarachnoidal Hemorrhage.
CONCLUSIONS The elevated prolactin levels that occur in patients with aSAH can be used in conjunction with other auxiliary factors that we believe may be beneficial to vasospasm. PMID: 28784938 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 10, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Cinnamaldehyde on Glucose Metabolism and Vessel Function.
Authors: Guo X, Sun W, Huang L, Wu L, Hou Y, Qin L, Liu T PMID: 28790298 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 10, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Differentiation Diagnosis of Hypo-Intense T2 Area in Unilateral Peripheral Zone of Prostate Using Magnetic Resonance Spectroscopy (MRS): Prostate Carcinoma versus Prostatitis.
Authors: Zhang TH, Hu CH, Chen JX, Xu ZD, Shen JK PMID: 28790299 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 10, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Association Between ABCB1 Gene Polymorphism and Renal Function in Patients with Hypertension: A Case-Control Study.
Authors: Chen X, Zhou T, Yang D, Lu J Abstract BACKGROUND A previous study found that target organ damage in patients with hypertension was related to genetic factors. The aim of our study aim was to explore the association between the ABCB1 gene and renal function injury induced by hypertension. MATERIAL AND METHODS We used a case-control study design. Patients with hypertension were enrolled from our hospital between July 2015 and December 2015. Questionnaire data included personal information, life habits and behavior. Clinical data included blood routine examination and liver and renal function. We used restric...
Source: Medical Science Monitor - August 10, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Dual-Dose Clopidogrel, Clopidogrel Combined with Tongxinluo Capsule, and Ticagrelor on Patients with Coronary Heart Disease and CYP2C19*2 Gene Mutation After Percutaneous Coronary Interventions (PCI).
CONCLUSIONS Adjusting the dose or combining with other drugs improves the efficacy of anti-platelet therapy and reduces the incidence of ischemic events after PCI. PMID: 28783717 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 9, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Platelet Derived Growth Factor Alpha (PDGFR α) Induces the Activation of Cardiac Fibroblasts by Activating c-Kit.
CONCLUSIONS Our data demonstrated that PDGF/PDGFRa induced the activation of cardiac fibroblasts by activating c-Kit. This study indicated that c-Kit could be used as a potential therapeutic target for treatment of cardiac fibrosis. PMID: 28780584 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 7, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Reduction Osteotomy versus Extensive Release on Clinical Outcome Measures in Simultaneous Bilateral Total Knee Arthroplasty.
In this study, we investigated the effect of RO compared to extensive medial soft tissue release (ER) on clinical outcome measures in simultaneous bilateral TKA. MATERIAL AND METHODS We prospectively enrolled 24 patients (48 knees) with bilateral varus knee deformity from July 2014 to December 20l5. For each patient, one knee was assigned to the RO group and the contralateral knee was assigned to ER group. One year postoperative, follow-up outcomes were collected and analyzed. RESULTS Time to 90° flexion of the knee was significantly different in the RO group (1.6±0.3 days) compared to the ER group (2.0±0.4 days) (p
Source: Medical Science Monitor - August 7, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Synergistic Effect of Notch-3-Specific Inhibition and Paclitaxel in Non-Small Cell Lung Cancer (NSCLC) Cells Via Activation of The Intrinsic Apoptosis Pathway.
CONCLUSIONS These results indicate a synergistic effect of Notch-3-specific inhibition and paclitaxel through alteration of the intrinsic apoptosis pathway, which was involved in Notch-3-induced chemoresistance in NSCLC cells, and GSI inhibited Notch-3-induced chemoresistance in a concentration-dependent manner. This approach that combines Notch-3-specific inhibition and paclitaxel would be likely to apply in NSCLC. PMID: 28769027 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Confirmed Transmission of Bacterial or Fungal Infection to Kidney Transplant Recipients from Donated After Cardiac Death (DCD) Donors in China: A Single-Center Analysis.
CONCLUSIONS Our kidney recipients showed high occurrence rates of donor-derived infection. Recipients with donor-derived infection were associated with higher mortality and graft loss than those without donor-derived infection. The majority of recipients with donor-derived infection who died did not receive appropriate antimicrobial therapy after infection. PMID: 28771455 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Modified Glasgow Prognostic Score at Recurrence Predicts Poor Survival in Resected Non-Small Cell Lung Cancer (NSCLC) Patients.
CONCLUSIONS mGPS at the time of recurrence might be an independent adverse prognostic factor in recurrent NSCLC. PMID: 28775246 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Total Oxidant/Antioxidant Status in Sera of Patients with Esophageal Cancer.
CONCLUSIONS Serum TOS, TAS, and OSI were significantly different between patients with EC and healthy controls. In patients with EC, these factors were not correlated with smoking or drinking history or with clinical stage. Patients with EC with higher TOS and OSI and lower TAS had a trend towards better outcomes but it did not reach significance. Serum TOS and OSI are potential diagnostic biomarkers that can be used to identify cases of EC. PMID: 28777781 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

The Prognostic Value of Epithelial Membrane Protein 1 (EMP-1) in Patients with Laryngeal Carcinoma.
Authors: Liu C, Wei X, Li F, Wang L, Ruan X, Jia J, Zhang X Abstract BACKGROUND In the present study, we aimed to investigate the prognostic value of epithelial membrane protein 1 (EMP-1) gene in patients diagnosed with laryngeal carcinoma (LC). MATERIAL AND METHODS Patients who were pathologically diagnosed with LC were enrolled in the present study. The expression levels of EMP-1 in tumor tissues and corresponding normal tissues collected from the LC patients were detected by semi-reverse transcriptase polymerase chain reaction (semi-RT-PCR). Chi-square analysis was used to evaluate the relationship between EMP-1...
Source: Medical Science Monitor - August 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Role of Interleukin-6 and Its Receptor in Endometriosis.
CONCLUSIONS Disorders involving IL-6 and IL-6R are correlated with the etiology of endometriosis. An increase in sIL-6R in peritoneal fluid promotes the development of endometriosis by enhancing the bioactivity of IL-6. PMID: 28779573 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Microsatellite and Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 Promoter with Insulin Sensitivity and Insulin Secretion.
CONCLUSIONS The CA microsatellite and rs35767 have no genotype-related difference in insulin sensitivity or secretion. The rs5742612 and rs2288377 polymorphisms are significantly associated with insulin biology, with the TT genotype exhibiting higher insulin sensitivity and lower insulin secretion compared with carriers of the C allele and A allele, respectively, mostly attributed to the direct functional roles of the two loci. PMID: 28761040 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 3, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Therapeutic Effect of Sodium Glucose Co-Transporter 2 Inhibitor Dapagliflozin on Renal Cell Carcinoma.
CONCLUSIONS Our results indicate that dapagliflozin has high efficiency and low toxicity and could be a new therapeutic target for RCC. PMID: 28763435 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 3, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Naringin on Monosodium Iodoacetate-Induced Osteoarthritis Pain in Rats.
CONCLUSIONS Naringin appears to be an effective therapeutic drug for the treatment of the OA and OA-related symptoms. PMID: 28765519 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 3, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of 3 Different Anesthesia Techniques Used in Total Hip Arthroplasty.
CONCLUSIONS CEA and SEA were more effective than GA in THA, and CEA seemed to be a better anesthesia technique than SEA. PMID: 28767640 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 3, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Predictors of Surgical Outcomes and Imaging Features in Single Segmental Cervical Spondylotic Myelopathy with Lower Cervical Instability.
Authors: Lu K, Gao X, Tong T, Miao D, Ding W, Shen Y Abstract BACKGROUND Cervical degenerative changes are the most common cause of cervical spondylotic myelopathy (CSM) and lower cervical instability (LCI). The purpose of this study was to investigate the associated factors of MRI signal changes and prognosis in single segmental CSM accompanied by LCI. MATERIAL AND METHODS A total of 122 patients met the inclusion criteria and were enrolled in this study with a minimum follow-up period of 2 years. According to the absence/presence of LCI, patients were divided into the unstable group (n=43 [35.2%]) and the stable ...
Source: Medical Science Monitor - August 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Relative Computed Tomography (CT) Enhancement Value for the Assessment of Microvascular Architecture in Renal Cell Carcinoma.
CONCLUSIONS The relative CT enhancement value of RCC was associated with vascular architecture parameters including density, area, and perimeter. Quantitative and semi-quantitative parameters on enhanced CT may shed some light on tumor vasculature and function as indicators of the biological behavior of RCC. PMID: 28757600 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Regenerating Family Member 4 (Reg4) Enhances 5-Fluorouracil Resistance of Gastric Cancer Through Activating MAPK/Erk/Bim Signaling Pathway.
CONCLUSIONS Reg4 inhibited apoptosis through regulating MAPK/Erk/Bim signaling pathway and thereby enhanced the resistance of GC to 5-FU. PMID: 28759561 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 2, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Computed Tomography (CT) Findings of Pulmonary Hydatid Cysts in Children and the Factors Related to Cyst Rupture.
In this study we aimed to comprehensively describe the CT signs for cysts and analyze the relationship of cyst ruptures to the diameter and location of cyst. MATERIAL AND METHODS A total of 145 cysts from 102 patients, aged 17 years or younger, who underwent a multi-detector computed tomography (MDCT) evaluation and had surgically proven pulmonary hydatid disease were included retrospectively. The CT images were analyzed for radiologic findings and signs of cyst rupture. RESULTS The cysts had a mean diameter of 5.45±3.03 cm. Most of the patients had a solitary cyst (70.6%). The most common lobes involved were the lo...
Source: Medical Science Monitor - July 31, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Performance of Cardiac Magnetic Resonance Imaging for Diagnosis of Myocarditis Compared with Endomyocardial Biopsy: A Meta-Analysis.
CONCLUSIONS CMRI based on LLC or its individual components seems to have moderate accuracy in diagnosis of acute or chronic myocarditis. PMID: 28755532 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 31, 2017 Category: Research Tags: Med Sci Monit Source Type: research

The Effect of SIN1 and Microtubules on Insulin Induced PKC ζ Activation.
CONCLUSIONS PKC ζ translocated from cytosol to membrane depending on SIN1, which suggested that PKC ζ may be activated directly by PI3K and the reaction probably carried out on microtubules in HepG2 cells. PMID: 28751630 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Differential Expression of Tubulin Acetylase and Deacetylase Between the Damaged Central and Peripheral Branch of Dorsal Root Ganglion Neurons.
CONCLUSIONS Our study indicated that insufficiency of acetylase and upregulation of deacetylase in DRG neurons after central axonal injury may contribute to the pathogenesis of cauda equine syndrome. PMID: 28753589 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 30, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Biomechanical Changes in Myopia Patients with Unsatisfactory Corneas After Femto Second-Laser In Situ Keratomileusis (FS-LASIK) Concurrent with Accelerated Corneal Collagen Cross-Linking Using Corvis-ST: Two-Year Follow-Up Results.
Authors: Xu W, Tao Y, Wang L, Huang Y Abstract BACKGROUND Some myopia patients with unsatisfactory corneas consider corneal refractive surgery for different reasons. Accelerated corneal collagen crosslinking (ACXL) is an effective method to enhance the resistance of the cornea. The present investigation was designed to evaluate the changes of biomechanical properties in patients with myopia and thin corneas after femtosecond-laser in situ keratomileusis (FS-LASIK) concurrent with ACXL. MATERIAL AND METHODS A prospective study was designed. A total of 22 eyes of 11 myopia astigmatism patients with unsatisfactory cor...
Source: Medical Science Monitor - July 28, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Increase of Autonomic Nerve Factors in Epicardial Ganglionated Plexi During Rapid Atrial Pacing Induced Acute Atrial Fibrillation.
Authors: Li Y, Lu YM, Zhou XH, Zhang L, Li YD, Zhang JH, Xing Q, Tang BP Abstract BACKGROUND The cardiac autonomic nervous system plays an essential role in epicardial ganglionated plexi (GP) regulation of atrial fibrillation onset and progression. To date, the activity of GP and the function of the cardiac autonomic nervous system are not well understood. The aim of this study was to determine alterations in epicardial GP cholinergic nerve, adrenergic nerve, and nerve growth factor expression using rapid atrial pacing to induce atrial fibrillation in canines. MATERIAL AND METHODS Nine healthy adult beagles were di...
Source: Medical Science Monitor - July 28, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Surgery for Infective Endocarditis: Outcomes and Predictors of Mortality in 360 Consecutive Patients.
Authors: Farag M, Borst T, Sabashnikov A, Zeriouh M, Schmack B, Arif R, Beller CJ, Popov AF, Kallenbach K, Ruhparwar A, Dohmen PM, Szabó G, Karck M, Weymann A Abstract BACKGROUND A retrospective analysis was conducted of the early and long-term outcomes after surgery for infective endocarditis (IE). MATERIAL AND METHODS We included 360 patients with IE operated upon between 1993 and 2012. The primary endpoint was overall cumulative postoperative survival at 30 days. Secondary endpoints were early postoperative outcomes and complication rates. Factors associated with 30-day mortality were analyzed. RESULTS Me...
Source: Medical Science Monitor - July 27, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Circulating Tumor DNA Levels and Response to Tyrosine Kinase Inhibitors (TKI) Treatment in Non-Small Cell Lung Cancer.
CONCLUSIONS Our study demonstrated a highly associative relation of ctDNA to NSCLC patients during treatment that can be utilized to gauge treatment response. CtDNA is an attractive means compared with conventional core needle biopsies and presents new methods for accurately profiling NSCLC disease progression. PMID: 28742791 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 27, 2017 Category: Research Tags: Med Sci Monit Source Type: research

The Clinical Signification of Claudin-11 Promoter Hypermethylation for Laryngeal Squamous Cell Carcinoma.
Authors: Shen Z, Cao B, Lin L, Zhou C, Ye D, Qiu S, Li Q, Cui X Abstract BACKGROUND Claudin-11 (CLDN11) is frequently silenced by its promoter hypermethylation. Previous studies have shown that CLDN11 promoter hypermethylation is a potential biomarker for diagnosing various cancers. The aim of this study was to investigate CLDN11 promoter methylation and its potential relevance to clinicopathologic features and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). MATERIAL AND METHODS Using the quantitative methylation-specific polymerase chain reaction (qMSP), CLDN11 promoter methylation was measure...
Source: Medical Science Monitor - July 27, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Significance and Prognostic Implications of Quantifying Pulmonary Contusion Volume in Patients with Blunt Chest Trauma.
CONCLUSIONS Quantifying pulmonary contusion volume could allow identification of patients at high-risk of ARDS. CTCV has a significant correlation with injury severity in patients with BCT. Further prospective studies are needed to address the validity of CTCV in the patients care. PMID: 28746303 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 27, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas.
CONCLUSIONS Our data indicate that combined blockade of Tim-3 and CEACAM1 generates robust therapeutic efficacy in mice with intracranial tumors, and provides a promising option for GBM immunotherapy. PMID: 28736431 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Fork Head Box Class O1 (FOXO1) Activates Bim Expression to Mediate Cardiac Apoptosis in Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy.
Authors: Li G, Jin M, He Y, Ren J, Zhang M, Chen Y, Lan X, Zhong J, Liu H PMID: 28738025 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 26, 2017 Category: Research Tags: Med Sci Monit Source Type: research