Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes.
We examined the level of fragile histidine triad (FHIT) and p16 gene methylation in patients with hepatocellular carcinoma and explored the relationship to liver cancer. MATERIAL AND METHODS There were 56 patients with primary liver cancer who were admitted to the hospital from July 2015 to October 2017 included in the liver cancer group, and 24 non-hepatoma patients (hepatitis A/hepatitis B/hepatitis C, liver cirrhosis, liver fibrosis, and fatty liver, alcoholic liver identified as a control group. Fasting venous blood samples were collected from the 2 groups. Methylation-specific PCR (MSP) was used to detect the methylat...
Source: Medical Science Monitor - February 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Functional Genetic Single-Nucleotide Polymorphisms (SNPs) in Cyclin-Dependent Kinase Inhibitor 2A/B (CDKN2A/B) Locus Are Associated with Risk and Prognosis of Osteosarcoma in Chinese Populations.
CONCLUSIONS Functional genetic polymorphisms in CDKN2A/B predict the susceptibility and outcome of osteosarcoma in Chinese individuals. PMID: 30774116 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Dynamic Fixation Versus Static Fixation for Distal Tibiofibular Syndesmosis Injuries: A Meta-Analysis.
CONCLUSIONS The dynamic fixation and static fixation methods are equal in clinical outcomes, with dynamic fixation needing fewer second interventions for DTSIs. PMID: 30776287 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

MiR-34b-3p Represses the Multidrug-Chemoresistance of Bladder Cancer Cells by Regulating the CCND2 and P2RY1 Genes.
CONCLUSIONS These results not only reveal new players regulating BCa chemoresistance, but also provide clues for effective chemotherapy for BCa patients. PMID: 30778022 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Silent Cerebral Infarcts Following Left-Sided Accessory Pathway Ablation in Wolff-Parkinson-White (WPW) Syndrome: A Preliminary Report.
CONCLUSIONS This is the first study documenting the presence of silent cerebral infarcts after WPW ablation. Further investigations are needed to evaluate the risk of silent cerebral infarcts associated with L-AP ablation. PMID: 30778023 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

CircRNA circ_0067934 Overexpression Correlates with Poor Prognosis and Promotes Thyroid Carcinoma Progression.
CONCLUSIONS circ_0067934 could improve the development of thyroid carcinoma by promoting EMT and PI3K/AKT signaling pathways. PMID: 30779728 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.
Authors: Liu P, Du R, Yu X Abstract BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. MATERIAL AND METHODS WST-1 and colony formation assays were used for cell viability assessment. Cell cycle analysis was performed by flow cytometry. Apoptosis was detected by AO/EB staining using fluorescence microscopy. Cell migration and inv...
Source: Medical Science Monitor - February 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Phosphatase Actin Regulator-1 (PHACTR-1) Knockdown Suppresses Cell Proliferation and Migration and Promotes Cell Apoptosis in the bEnd.3 Mouse Brain Capillary Endothelial Cell Line.
CONCLUSIONS Phactr-1 was shown to have a role in the inhibition of endothelial cell proliferation and migration, promoted cell apoptosis, and regulated matrix metalloproteinases and apoptosis-associated proteins. These findings indicate that the expression of the Phactr-1 should be studied further in the cerebral microvasculature, both in vitro and in vivo, regarding its potential as a diagnostic and therapeutic target for cerebral microvascular disease. PMID: 30772888 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Surgical Resection of Primary Ewing's Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis.
Authors: Ren Y, Zhang Z, Shang L, You X Abstract BACKGROUND Metastatic Ewing's sarcoma (ES) of bone has a poor prognosis. Because there have been few previous studies on the prognostic factors and clinical outcome in patients with ES who have metastases at presentation, the aim of this study was to use the Surveillance, Epidemiology, and End Results (SEER) database to compare the clinical outcome following single and combined radiation treatment and surgery. MATERIAL AND METHODS The SEER database was used to identify patients with ES who presented with bone involvement and metastasis between 1973 to 2015. Prognosti...
Source: Medical Science Monitor - February 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Acupuncture as an Adjunctive Treatment for Angina Due to Coronary Artery Disease: A Meta-Analysis.
CONCLUSIONS Meta-analysis supported a positive treatment effect for the use of acupuncture when used as adjunctive therapy in patients with angina due to CAD. PMID: 30770700 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Activation of the Programmed Cell Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) Pathway and Pain in Patients with Cancer.
Authors: Zhang J, Zhang H, Luo Y Abstract BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. RESULTS The positive expression rate of PD-1 in sPD-1 and T cells of patients with cancer pain was higher than that in nor...
Source: Medical Science Monitor - February 18, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Myocardial Performance in Elite Athletes: The Role of Homocysteine, Iron, and Lipids.
CONCLUSIONS In this study, various biochemical markers were evaluated for possible association with left ventricle MPI as a surrogate of cardiac performance. Among these biomarkers, only low-density lipoprotein was significantly associated with MPI in elite athletes. PMID: 30760696 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

The Octamer-Binding Transcription Factor 4 (OCT4) Pseudogene, POU Domain Class 5 Transcription Factor 1B (POU5F1B), is Upregulated in Cervical Cancer and Down-Regulation Inhibits Cell Proliferation and Migration and Induces Apoptosis in Cervical Cancer Cell Lines.
CONCLUSIONS POU5F1B was upregulated in cervical cancer and down-regulation inhibited cell proliferation and migration and induced apoptosis in cervical cancer cell lines by modulating OCT4. Further studies are required to determine whether POU5F1B might be a diagnostic or prognostic biomarker or therapeutic target in cervical cancer. PMID: 30762028 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of Long Noncoding RNA POU5F1B Promotes Radiosensitivity in Esophageal Carcinoma.
Authors: Meng B, Xing Y, Li H, Gao F, Liu YC Abstract BACKGROUND POU5F1B, serving as a carcinogen, participates in radiosensitivity of several tumors. However, in esophageal cancer, its potential mechanism and function in regulating radiosensitivity remain unclear. MATERIAL AND METHODS The expression level of POU5F1B was detected in plasma of esophageal tumor patients and cancer cell lines. The effect of POU5F1B knockdown on cell proliferation and colony formation was determined using CCK-8 assay and colony formation assay. Cell apoptosis rate was detected by flow cytometry. RESULTS POU5F1B expression level decline...
Source: Medical Science Monitor - February 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis.
CONCLUSIONS Resveratrol can reduce the oxidative damage and apoptosis of podocytes induced by high-glucose stimulation via SIRT1/PGC-1α-mediated mitochondrial protection. PMID: 30765684 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor- κB (NF-κB).
CONCLUSIONS Simvastatin attenuates cardiac hypertrophy in diabetic rats, which might be due to the attenuation of oxidative stress and inflammation induced by calpain-1-mediated activation of NF-κB. PMID: 30767945 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA TFAP2A-AS1 Inhibits Cell Proliferation and Invasion in Breast Cancer via miR-933/SMAD2.
CONCLUSIONS Results from the present study suggest that TFAP2A-AS1 acts as a tumor suppressor in BC via the miR-933/SMAD2 axis. PMID: 30768589 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of the Use of Vonoprazan and Proton Pump Inhibitors for the Treatment of Peptic Ulcers Resulting from Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis.
CONCLUSIONS The findings of the systematic review and meta-analysis showed that the efficacy of vonoprazan was comparable with PPIs for the treatment of peptic ulcers following ESD. Further studies are required to support the safety and efficacy of vonoprazan compared with different types of PPIs. PMID: 30755541 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats.
CONCLUSIONS NGR1 exerts a protective effect on CAG, and it is a multi-target, multi-linked, comprehensive process. PMID: 30757999 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Remifentanil-Based Fast-Track and Fentanyl-Based Routine Cardiac Anesthesia for Intraoperative Device Closure of Atrial Septal Defect (ASD) in Pediatric Patients.
Authors: Huang Q, Lin LY, Lin XZ Abstract BACKGROUND The aim of this study was to evaluate the effectiveness and safety of remifentanil-based fast-track anesthesia for intraoperative device closure of atrial septal defects (ASDs). MATERIAL AND METHODS The clinical data of 152 pediatric patients who received intraoperative device closure of ASD in our hospital from January 2015 to December 2017 were retrospectively analyzed. Patients were divided into 2 groups: group F (remifentanil-based fast-track anesthesia group, n=72) and group C (fentanyl-based routine anesthesia group, n=80). The relevant data from 2 groups w...
Source: Medical Science Monitor - February 15, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF- κB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats.
Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats. Med Sci Monit. 2019 Feb 11;25:1113-1121 Authors: Wu Q, Liu H, Zhou M Abstract BACKGROUND Diabetic retinopathy (DR) is a macrovascular complication that occurs in diabetic patients. Conventional treatments for the management of DR have many limitations. Thus, the present investigation evaluated the protective effect of fangchinoline against diabetic retinopathy (...
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?
This article summarizes recent research on MYH9 and provides a reference for future clinical research. PMID: 30739906 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene.
CONCLUSIONS The results of this study showed that miR-205 and miR-338-3p downregulated the expression of the BCL2 gene and decreased apoptosis in prostate carcinoma. PMID: 30741252 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression of a Novel Long Noncoding RNA (lncRNA), GASL1, is Downregulated in Patients with Intracranial Aneurysms and Regulates the Proliferation of Vascular Smooth Muscle Cells In Vitro.
CONCLUSIONS Expression of the novel lncRNA, GASL1, was downregulated in patients with intracranial aneurysms and regulated the proliferation of VSMCs in vitro by targeting TGF-β1. PMID: 30742604 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Identification of RNA Expression Profiles in Thyroid Cancer to Construct a Competing Endogenous RNA (ceRNA) Network of mRNAs, Long Noncoding RNAs (lncRNAs), and microRNAs (miRNAs).
CONCLUSIONS Differential RNA expression profiling in thyroid cancer was used to construct a ceRNA network of mRNAs, lncRNAs, and miRNAs that showed potential in evaluating prognosis. PMID: 30745559 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparative Ef ficacy of Budesonide/Formoterol with Budesonide, Formoterol or Placebo for Stable Chronic Obstructive Pulmonary Disease: A Meta-Analysis.
CONCLUSIONS For stable COPD patients, compared with controls (monocomponents or placebo), budesonide/formoterol improved pulmonary function and health status. Future larger long-term RCTs are warranted to assess the beneficial clinical efficacy of budesonide/formoterol in COPD patients. PMID: 30747109 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Comparative Study on Functional Recovery, Complications, and Changes in Inflammatory Factors in Patients with Thoracolumbar Spinal Fracture Complicated with Nerve Injury Treated by Anterior and Posterior Decompression.
Authors: Jiang Y, Wang F, Yu X, Li Z, Liang L, Ma W, Zhang G, Dong R Abstract BACKGROUND The aim of this study was to evaluate 2 methods to treat patients with thoracic lumbar spine fracture with merging spinal cord injury, including complications of surgery and the influence of inflammatory factors. MATERIAL AND METHODS Eighty patients were randomly divided into an anterior decompression group (study group) or a posterior decompression group (control group) to observe perioperative complications, evaluate preoperative and postoperative nerve function, and evaluate the 6-month injured vertebral height and Cobb angl...
Source: Medical Science Monitor - February 13, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Anti-Diabetogenic Properties of Mineralocorticoid Receptor Antagonists: Implications for Enhanced Safety and Efficacy of Post-Transplantation Pharmacotherapies.
Authors: Ming Y, Stefano GB, Kream RM, Zhuang Q Abstract Widespread usage of the calcineurin inhibitors tacrolimus and cyclosporine A as post-transplantation immunosuppressive agents is fraught with severe nephrotoxic and diabetogenic side effects. More recently, tapering of calcineurin inhibitor-based immunotherapies with concurrent administration of the mammalian target of rapamycin (mTOR) inhibitors sirolimus and everolimus has been employed within pharmacological regimens designed to achieve better safety and efficacy for preservation of allograft kidney function. Collected preclinical data and recent clinical ...
Source: Medical Science Monitor - February 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Advanced Hepatocellular Carcinoma with Bone Metastases: Prevalence, Associated Factors, and Survival Estimation.
CONCLUSIONS A list of factors associated with BM occurrence and the prognosis of the advanced HCC patients with BM were found. These associated factors may provide a reference for BM screening in HCC and guide prophylactic treatment in clinical settings. PMID: 30739123 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 12, 2019 Category: Research Tags: Med Sci Monit Source Type: research

CYFRA 21-1 and Placental Growth Factor as Screening Markers for Endometriosis.
CONCLUSIONS CYFRA 21-1 and PIGF may be promising markers to identify patients with and without ovarian endometriosis. PMID: 30737365 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Comparative Study of Bolus Norepinephrine, Phenylephrine, and Ephedrine for the Treatment of Maternal Hypotension in Parturients with Preeclampsia During Cesarean Delivery Under Spinal Anesthesia.
CONCLUSIONS A bolus dose of norepinephrine showed similar efficacy to phenylephrine but improved maternal and neonatal safety in parturients with preeclampsia with hypotension during cesarean section under spinal anesthesia. PMID: 30738019 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 10, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Probucol Protects Against Contrast-Induced Acute Kidney Injury via the Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2)/JNK-Caspase 3 Pathway in Diabetic Rats.
CONCLUSIONS Probucol exerts protective effects on contrast-induced acute kidney injury in diabetic rats by inhibition of renal cell apoptosis. This is achieved by reducing mitochondrial caspase-3 expression through increasing and decreasing the expression of the upstream mediators p-ERK1/2 and p-JNK, respectively. PMID: 30728344 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Quantitative Electroencephalogram During Sleep in Depressed and Non-Depressed Patients with Parkinson's Disease.
Authors: Liu K, Ma Q, Wang M Abstract BACKGROUND Depression is one of the most important factors affecting quality of life in Parkinson's patients. Most research on Parkinson's disease with depression has focused on neuroimaging, and there have been few quantitative electroencephalogram studies. Sleep is a biomarker for depression; therefore, the aim of this study was to identify differences in quantitative electroencephalograms during sleep in depressed and non-depressed patients with Parkinson's disease. MATERIAL AND METHODS We assessed 38 Parkinson's disease patients (26 depressed patients, 12 non-depressed pati...
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Effectiveness of Parecoxib Sodium Combined with Transversus Abdominis Plane Block for Pain Management After Hepatectomy for Hepatocellular Carcinoma: A Prospective Controlled Study.
CONCLUSIONS Parecoxib sodium combined with TAP block effectively reduced postoperative pain, improved ambulation, improved gastrointestinal function, and shortened hospitalization time following hepatectomy in patients with HCC without adverse effects. PMID: 30730866 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association of Dietary Potassium Intake with the Development of Chronic Kidney Disease and Renal Function in Patients with Mildly Decreased Kidney Function: The Korean Multi-Rural Communities Cohort Study.
CONCLUSIONS Dietary potassium was associated with lower risk of CKD development and eGFR decline, and this association was observed only in hypertensives. PMID: 30733429 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

HIPK1 Interference Attenuates Inflammation and Oxidative Stress of Acute Lung Injury via Autophagy.
CONCLUSIONS Decreased HIPK1 in ALI showed protective effects in attenuating inflammation and oxidative stress and enhancing autophagy, indicating HIPK1 as a possible target in ALI management. PMID: 30734722 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Occupational Factors Causing Pain Among Nurses in Mainland China.
CONCLUSIONS The main cause of pain among nurses in mainland China is occupational factors, and the current status of this problem is not satisfactory. PMID: 30734723 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Adiponectin Gene rs1501299 Polymorphism and Nonalcoholic Fatty Liver Disease Susceptibility: A Systematic Review and Meta-Analysis.
CONCLUSIONS Results from our current meta-analysis gave insight into the correlation between rs1501299 polymorphism and the risk of NAFLD, indicating the variant of rs1501299 might be related to increased NAFLD susceptibility. PMID: 30735485 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity.
Authors: Wang Y, Li S, Li C Abstract Vitiligo is an autoimmune cutaneous disease in which melanocytes are destroyed by CD8⁺ T cells resulting in disfiguring white spots. From the very beginning of the disease, oxidative stress plays a significant role in promoting the onset of vitiligo, as noted by many studies. Multiple factors lead to the overproduction of reactive oxygen species (ROS), and collaboratively cause ROS accumulation in vulnerable melanocytes. However, ROS are responsible for melanocyte damage manifested by the level of molecules, organelles, and cells, and the generation of autoantigens, through di...
Source: Medical Science Monitor - February 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Altered Corneal Nerves in Chinese Thyroid-Associated Ophthalmopathy Patients Observed by In Vivo Confocal Microscopy.
Authors: Wu LQ, Mou P, Chen ZY, Cheng JW, Le QH, Cai JP, Wei RL Abstract BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study. Central corneal subbasal nerve density and morphology were evaluated with in vivo laser scanning confocal microscopy and quantified using automated CCmetrics software. RESULTS The values of the central corneal subbasal nerve plexus parameters of both active and inactive TAO patie...
Source: Medical Science Monitor - February 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Assessment of Clinical and Echocardiographic Findings of Pregnant Women with Dyspnea.
CONCLUSIONS When echocardiography findings of pregnant women with dyspnea were analyzed, it was determined that their left ventricle end-diastolic diameter (LVEDd), left ventricle end-systolic diameter (LVESd), and systolic pulmonary artery pressure (sPAP), calculated through tricuspid insufficiency, were higher than those of women in the control group, although they were within normal limit range. Therefore, we recommend that women with dyspnea should see a cardiologist and undergo an echocardiogram test so that the cardiac causes of dyspnea can be clinically revealed. PMID: 30726202 [PubMed - in process] (Source: Med...
Source: Medical Science Monitor - February 8, 2019 Category: Research Tags: Med Sci Monit Source Type: research

A Controlled Study of the Feasibility and Efficacy of a Cloud-Based Interactive Management Program Between Patients with Psoriasis and Physicians.
CONCLUSIONS Cloud-based interactive patient and physician management improved the mental health and quality of life for patients with psoriasis and allowed patients to manage their disease more effectively. PMID: 30713334 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC).
CONCLUSIONS The Twist gene might be involved in the occurrence and development of NSCLC, which is correlated with patient prognosis. PMID: 30714578 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation.
Authors: Xu Z, Zhou X, Chen G Abstract BACKGROUND The expression and mechanism of IL-1, IL-2, IL-8, BMP, FGF1, and IGF-1 in Sprague-Dawley (SD) rats with lumbar disc herniation were investigated. MATERIAL AND METHODS Immunohistochemical methods were applied to identify IL-1, IL-2, IL-8, BMP, FGF1, and IGF-1. PI3K, AKT protein, and mRNA expression were detected and analyzed by Western blot analysis. We selected 30 healthy SD rats and divided them into 2 groups to construct an animal model that was validated by immediate CT scanning. Cartilage tissues from the lumbar disc herniation (experimental) group and control g...
Source: Medical Science Monitor - February 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model.
CONCLUSIONS The therapeutic potential of SeNPs was confirmed through histological observation of angle joints in different experimental animals. Our results collectively suggest that SeNPs dispersed in CA can be an effective therapeutic agent for inflammatory disorders like acute gouty arthritis. PMID: 30718447 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Alzheimer's Disease: A Comparison of Eyes of Patients with Alzheimer's Disease, Primary Open-Angle Glaucoma, and Preperimetric Glaucoma and Healthy Controls.
CONCLUSIONS Neuronal damage in the central nervous system (CNS) also affects to retinal axons. A major problem is to distinguish the cause for a moderate decrease in the RNFL thickness. This is particularly true for patients with glaucoma who have not been diagnosed with changes in the visual field. It is not possible to distinguish the cause of a mild decrease in the RNFL thickness based on the SD-OCT. This may result in misdiagnosis of glaucoma, unnecessary use of anti-glaucoma eye drops, and a delayed diagnosis of AD. PMID: 30720005 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Upregulation of Nuclear Factor IA Suppresses Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Umbilical Vein Endothelial Cells.
CONCLUSIONS These results demonstrated that NFIA might have beneficial effects in the prevention of ox-LDL-induced ERS and apoptosis in vascular endothelial cells. This study provided new insights into the mechanism of atherosclerosis. PMID: 30721172 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential.
CONCLUSIONS In brief, these results reveal that glychionide-A significantly inhibits the growth of pancreatic cancer cells via inducing apoptosis and autophagy, and could prove valuable in the chemotherapeutic treatment of pancreatic cancer. Therefore, further research is needed, especially more advanced in vivo experiments. PMID: 30712054 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Physical Crossmatch and Virtual Crossmatch to Identify Preexisting Donor-Specific Human Leukocyte Antigen (HLA) Antibodies and Outcome Following Kidney Transplantation.
CONCLUSIONS High-resolution epitope analysis identified fewer cases with DSA compared with serological analysis. Because patients with and without sDSA had a similar short-term outcome in the setting of a negative PXM, the presence of preexisting sDSA, determined by VXM, should not be an absolute contraindication for kidney transplantation. PMID: 30712055 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 5, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Comprehensive Bioinformatics Analysis of the Immune Mechanism of Dendritic Cells Against Measles Virus.
CONCLUSIONS The DEGs increased gradually with the duration of MV infection. The type I interferon signaling pathway and the defense response to viral processes can be activated against MV by ISG15 and CXCL10 in DCs. These may provide novel targets for the treatment of MV. PMID: 30705250 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research