Relationship Between Preoperative Low-Density Lipoprotein Cholesterol and Periprocedural Myocardial Injury in Patients Following Elective Percutaneous Coronary Intervention in Southern China.
This study included 1942 consecutive patients who received elective PCI. Cardiac troponin I (cTnI) was used to assess perioperative myocardial injury. The peak cTnI was measured within 24 h after PCI, and the correlation between the cTnI value and the preoperative LDL level was studied. RESULTS The data suggest that the PCI patients with preprocedural LDL-C
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Features of Chromosome 6 Translocation in Male Carriers: A Report of 10 Cases and Review of the Literature.
CONCLUSIONS Chromosome translocations involving chromosome 6 influence fertility status and lead to increased risk of miscarriage. Cytogenetic screening before opting for assisted reproductive technology and the breakpoints of chromosome 6 translocation should be considered for infertile male carriers. PMID: 29911662 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Birth Month and Course of Recurrent Depressive Disorders in a Polish Population.
CONCLUSIONS The results obtained indicate that birth month may be significantly associated with the course of recurrent depressive disorders. In patients from Central Europe, the first trimester of pregnancy falling in autumn and winter seems to be significant. These results need to be interpreted with caution due to the small size of the examined group. PMID: 29912861 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Lipid Biomarkers in Acute Myocardial Infarction Before and After Percutaneous Coronary Intervention by Lipidomics Analysis.
CONCLUSIONS Lipidomics analysis demonstrated differential change before and after reperfusion, suggesting a potential role of some of these lipids as biomarkers for optimizing the diagnosis of myocardial I/R, as well as for therapeutic targets against myocardial I/R injury. PMID: 29913478 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Effect of Radiotherapy Combined with Chemotherapy for Non-Surgical Treatment of the Esophageal Squamous Cell Carcinoma.
CONCLUSIONS Treating non-surgical ESCC patients with CCRT conferred a significant survival benefit compared with RT alone. CCT after CCRT prolongs PFS but does not increase acute toxicity. High-dose (60-65 Gy) CCRT could generate more favorable survival outcomes. PMID: 29915168 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

High-Risk Factors for Suppurative Mastitis in Lactating Women.
This study aimed to identify the high-risk factors for suppurative mastitis (SM) in women who were breastfeeding. MATERIAL AND METHODS A total of 262 non-SM patients and 63 SM patients admitted to the Department of Breast and Thyroid Surgery of Liaocheng People's Hospital were retrospectively enrolled in this study. The high-risk factors for SM during lactation were determined by assessing admission time after acute mastitis, galactostasis, primipara or pluripara, nipple injuries, antibiotic treatment course, and diabetes. RESULTS The incidence of SM in patients with admission time greater than 72 h after occurrence of acu...
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Bronchoalveolar Lavage Components Applying Confocal Laser Endomicroscopy.
CONCLUSIONS Using CLE, alveolar macrophages and leucocytes in stained BALF can be differentiated independent of smoking status. Further studies should be initiated in order to subclassify leucocytes in eosinophilic, neutrophilic granulocytes, and lymphocytes, which is important for routine clinical practice. PMID: 29920509 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Application of Isobaric Tags for Relative and Absolute Quantification (iTRAQ) Coupled with Two-Dimensional Liquid Chromatography/Tandem Mass Spectrometry in Quantitative Proteomic Analysis for Discovery of Serum Biomarkers for Idiopathic Pulmonary Fibrosis.
CONCLUSIONS The present study demonstrates that levels of CRP and fibrinogen-a are higher and levels of haptoglobin and kininogen-1 are lower in patients with IPF compared to levels in healthy controls. We found they are useful candidate biomarkers for IPF. PMID: 29909421 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Expression of Transcription Factor 21 (TCF21) and Upregulation Its Level Inhibits Invasion and Metastasis in Esophageal Squamous Cell Carcinoma.
CONCLUSIONS TCF21 is downregulated in ESCC, and its low expression is closely correlated with N stage and predicts a poor prognosis. TCF21 functions as a tumor suppressor in ESCC progression, and enhancement of its expression levels may be partly through promoting Kiss-1 expression to reverse EMT by modulating EMT-related gene expression. Thus, TCF21 can potentially be used as a treatment target for ESCC. PMID: 29909422 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Prucalopride Inhibits Proliferation of Ovarian Cancer Cells via Phosphatidylinositol 3-Kinase (PI3K) Signaling Pathway.
CONCLUSIONS The present study reveals that in ovarian cancer cells, prucalopride inhibits proliferation, migration, and invasion, and induces apoptosis and autophagy, which may be regulated by the PI3K signaling pathway. These results suggest prucalopride has potential as a new drug for clinical ovarian cancer treatment. PMID: 29909423 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury.
CONCLUSIONS All these findings demonstrate that Bevacizumab treatment ameliorated cartilage degradation in rats subjected to chronic sports arthritic injury. Our results provide evidence supporting use of targeted therapy for VEGF in the clinical treatment of chronic sports arthritic injury. PMID: 29904041 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Liver Disease During Pregnancy: A Challenging Clinical Issue.
Authors: Mikolasevic I, Filipec-Kanizaj T, Jakopcic I, Majurec I, Brncic-Fischer A, Sobocan N, Hrstic I, Stimac T, Stimac D, Milic S Abstract One of the least studied topics in the field of obstetrics is liver disease during pregnancy, which creates a challenge for both gynecologists and hepatologists. Approximately 3% of pregnant women are affected by some form of liver disease during pregnancy. Some of these conditions can be fatal for both the mother and child. In addition, 3 types of liver disease need to be differentiated during pregnancy. One type is liver disease directly related to pregnancy, which can occu...
Source: Medical Science Monitor - June 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Different Esthetic Post-Core Materials on Color of Direct-Composite Restorations: A Preliminary Clinical Study.
CONCLUSIONS Definitive restorations were equally affected by the 2 materials. Both materials can be used reliably in clinical practice. However, further research that focuses on the effect of intraoral conditions is needed. PMID: 29906270 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Development of a Quality of Sexual Life Questionnaire for Breast Cancer Survivors in Mainland China.
Authors: Jing LW, Zhang C, Jin F, Wang AP Abstract BACKGROUND There is a great need for a quality of sexual life questionnaire (QVS) in breast cancer survivors (BCSs) based on the Chinese social culture since the imported tools lack localization verification. To develop a QVS in BCSs and determine its validity and reliability. MATERIAL AND METHODS In the qualitative study, a total of 21 BCSs were interviewed by purposive sampling and snowball sampling; and in the quantitative study, a total of 249 BCSs, who were admitted and received outpatient follow-up, were investigated. Regarding construct validity, factor anal...
Source: Medical Science Monitor - June 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Authors: Wang Y, Liu M, Yang P, Peng H Abstract BACKGROUND Osteosarcoma and fibrosarcoma are malignant tumors with poor prognosis. Peroxiredoxin 1 (PRDX1) is considered to prevent tumors in many malignances. However, few studies have focused on the functions of PRDX1 in osteosarcoma and fibrosarcoma. MATERIAL AND METHODS PRDX1 mRNA in tumors and adjacent tissues of 32 osteosarcoma patients and 16 fibrosarcoma patients was extracted and measured. Proliferation and invasion of MG63 and HT1080 cell lines after silencing or overexpressing PRDX1 were used to detect the role of PRDX1 in metastasis of osteosarcoma and fib...
Source: Medical Science Monitor - June 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Role of MicroRNA-181a in Myocardial Fibrosis Following Myocardial Infarction in a Rat Model.
Authors: Chen P, Pan J, Zhang X, Shi Z, Yang X Abstract BACKGROUND The role of miR-181a in the development of cardiac disease and in particular, myocardial fibrosis following myocardial infarction (MI) remains unknown. The aim of this study was to explore the role of miR-181a in myocardial fibrosis in a rat model of MI and the expression of TGF-β receptor III (TβRIII). MATERIAL AND METHODS Forty adult male Wistar rats were randomly divided into an MI model group (n=30) and a control group with (n=10). The rat MI model involved ligating the left anterior descending (LAD) coronary artery in the model group;...
Source: Medical Science Monitor - June 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Cervical Cancer Cell Growth, Drug Resistance, and Epithelial-Mesenchymal Transition Are Suppressed by g-Secretase Inhibitor RO4929097.
CONCLUSIONS Notch signaling pathway plays an important role in the development and progression of cervical cancer. Blockade of the Notch pathway using GSI RO4929097 inhibited cell growth and reduced chemoresistance, invasion, metastasis, and EMT in cervical cancer cells. PMID: 29899322 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Whey Acidic Protein/Four-Disulfide Core Domain 21 Regulate Sepsis Pathogenesis in a Mouse Model and a Macrophage Cell Line via the Stat3/Toll-Like Receptor 4 (TLR4) Signaling Pathway.
CONCLUSIONS Wfdc21 plays a critical role in the pathogenesis of sepsis and may provide a therapeutic target for sepsis treatment. PMID: 29900929 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Curcumin Promotes Femoral Fracture Healing in a Rat Model by Activation of Autophagy.
CONCLUSIONS The findings of this study, in a rat model of femoral bone fracture healing, showed that curcumin promoted bone healing and autophagy, which were reduced by treatment with 3-MA, a known inhibitor of autophagy. PMID: 29902161 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Combined Hyperbaric Oxygen Partial Pressure at 1.4 Bar with Infrared Radiation: A Useful Tool To Improve Tissue Hypoxemia?
Authors: Dünnwald T, Held J, Balan P, Pecher O, Zeiger T, Hartig F, Mur E, Weiss G, Schobersberger W Abstract Tissue hypoxia contributes to the pathogenesis of several acute and chronic diseases. Hyperbaric oxygen therapy (HBO) and whole-body warming using low-temperature infrared technology (LIT) are techniques that might improve hypoxemia. Combining HBO and LIT as hyperbaric oxygen therapy combined with low-temperature infrared radiation (HBOIR) might be an approach that results in positive synergistic effects on oxygenation. LIT increases blood flow and could reduce HBO-induced vasoconstriction, and hyperox...
Source: Medical Science Monitor - June 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Changes in Gray Matter Density, Regional Homogeneity, and Functional Connectivity in Methamphetamine-Associated Psychosis: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.
CONCLUSIONS The abnormalities in brain structure and FC were associated with the development of MAP. PMID: 29897049 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Test Socket on Pain, Prosthesis Satisfaction, and Functionality in Patients with Transfemoral and Transtibial Amputations.
Authors: Aydın A, Çağlar Okur S Abstract BACKGROUND The aim of this retrospective study was to investigate the frequency of admissions, reason for admissions, and test socket satisfaction in patients who received a lower-limb prosthesis with or without a test socket in our unit. MATERIAL AND METHODS A total of 88 patients (54 men, 34 women) were included in the study. Patients were divided into 2 groups: the group with test socket (Group I, 44 patients) and the group without test socket (Group II, 44 patients). Variables related to the functional status, frequency of complaints, and test socket satisfactio...
Source: Medical Science Monitor - June 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Metabolomic Profiling of Plasma Samples from Women with Recurrent Spontaneous Abortion.
Authors: Li X, Yin M, Gu J, Hou Y, Tian F, Sun F Abstract BACKGROUND Gas chromatography coupled with mass spectrometry (GC-MS) and liquid chromatography coupled with mass spectrometry (LC-MS) metabolomics have been deployed to detect novel differential metabolites in cases with recurrent spontaneous abortion (RSA). MATERIAL AND METHODS Fifty patients who had recurrent spontaneous abortions (RSAs) and 51 control patients (age, gestational age, and body mass index (BMI) match) were enrolled in this study. Untargeted GC-MS and targeted LC-MS were combined to discover and validate the different metabolomic profiles bet...
Source: Medical Science Monitor - June 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.
Authors: Prochazka V, Jonszta T, Czerny D, Krajca J, Roubec M, Macak J, Kovar P, Kovarova P, Pulcer M, Zoubkova R, Lochman I, Svachova V, Pavliska L, Vrtkova A, Kasprak D, Gumulec J, Weisel JW Abstract BACKGROUND The aim of the study was to investigate the role of von Willebrand factor (vWF), the vWF-cleaving protease, ADAMTS13, the composition of thrombus, and patient outcome following mechanical cerebral artery thrombectomy in patients with acute ischemic stroke. MATERIAL AND METHODS A prospective cohort study included 131 patients with ischemic stroke (
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model.
CONCLUSIONS ADMSCs affected brain injury in multiple ways, not only by suppressing inflammation in the brain infarction area, but also by blocking ER stress-induced apoptosis. PMID: 29888735 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA (lncRNA) n379519 Promotes Cardiac Fibrosis in Post-Infarct Myocardium by Targeting miR-30.
CONCLUSIONS These findings reveal a novel function of n379519-miR-30 axis as a negative regulator for the treatment of MI-induced cardiac fibrosis and the associated cardiac dysfunction. PMID: 29889825 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Feasibility of Extended Dissection of Lateral Pelvic Lymph Nodes During Laparoscopic Total Mesorectal Excision in Patients with Locally Advanced Lower Rectal Cancer: A Single-Center Pilot Study After Neoadjuvant Chemotherapy.
CONCLUSIONS Laparoscopic LPLN dissection is feasible in patients with LARC and clinically swollen LPLNs, even after NAC. PMID: 29890514 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Mediating Effects of Patients' Stigma and Self-Efficacy on Relationships Between Doctors' Empathy Abilities and Patients' Cellular Immunity in Male Breast Cancer Patients.
CONCLUSIONS Doctors' empathy abilities affected breast cancer patients' NK subset through their stigma and self-efficacy. The mental health of male breast cancer patients need more attention and empathy education needs to be improved. PMID: 29891832 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of TBC1 Domain Family Member 24 (BC1D24) Inhibits Breast Carcinoma Growth via IGF1R/PI3K/AKT Pathway.
Authors: Qu X, Zhao B, Hu M, Ji Z, Xu J, Xia W, Qu Y Abstract BACKGROUND TBC1 domain family member 24 (TBC1D24) pathogenic mutations affect its binding to ARF6 and then result in severe impairment of neuronal development. However, there are no reports about the expression and function of TBC1D24 in cancer. The aim of the present study was to evaluate the effect of proliferation, migration, and invasion after silencing TBC1D24 expression in breast cancer MCF-7 cells, and to elucidate the potential mechanism of TBC1D24 in breast cancer. MATERIAL AND METHODS The expression of TBC1D24 in breast cancer tissues and the a...
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Role of Hydroxysteroid Dehydrogenase-Like 2 (HSDL2) in Human Ovarian Cancer.
CONCLUSIONS This study shows that HSDL2 upregulation is associated with ovarian cancer progression. HSDL2 knockdown inhibited cell proliferation, colony formation, motility, and tumorigenesis. It induced apoptosis and cell cycle arrest and might therefore serve as a potential target for ovarian cancer therapy. PMID: 29894468 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Ginsenoside Ameliorates Cognitive Dysfunction in Type 2 Diabetic Goto-Kakizaki Rats.
CONCLUSIONS The possible mechanism was related to inhibiting brain oxidative/nitrosative damage and affecting the expression of the cytokines IL-1β, IL-6, and TNF-α. PMID: 29886506 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 12, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Ground Kayak Paddling Exercise Improves Postural Balance, Muscle Performance, and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial.
In this study, adherence to the regimen was 96% in the GKP group. Postural balance, muscle performance, and cognitive function were significantly improved after intervention (p
Source: Medical Science Monitor - June 12, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Efficacy of Ciliary Ring Incision Combined with Modified Partial Pars Plana Vitrectomy for Malignant Glaucoma.
CONCLUSIONS Ciliary ring incision combined with modified partial pars plana vitrectomy for malignant glaucoma not only provided a clear and reliable intraoperative vitrectomy channel, but it also caused less disturbance of intraocular tissue structure and fewer complications. It also has the advantage of preserving the lens and avoiding further damage to the anatomy in the anterior segment of the eye. PMID: 29886508 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 12, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis.
CONCLUSIONS Upregulation of KIF26B enhanced proliferation and migration of ovarian cancer cells in vitro. Bioinformatics analysis supported the association between increased expression of the KIF26B gene and reduced clinical outcome in patients with ovarian carcinoma. PMID: 29880787 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Significance of Magnetic Resonance Imaging (MRI) T2 Hyperintense Endo-Vessels Sign in Progressive Posterior Circulation Infarction.
Authors: Xu J, Chen X, Lin M Abstract BACKGROUND MRI FLAIR hyperintense vessels sign (FHVs) is a special imaging marker that plays a key role in acute infarction imaging and diagnosis. However, FHVs have not been studied in the context of progressive posterior circulation infarction (PPCI), and little is known about the association of hyperintense endo-vessels sign (HEVs) on transverse section MRI with infarction. Thus, our objective here was to investigate the clinical significance of transverse MRI T2 HEVs in patients with PPCI. MATERIAL AND METHODS In this retrospective, case-control study, we enrolled 100 conse...
Source: Medical Science Monitor - June 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Significance of Serological and Urological Levels of Bladder Cancer-Specific Antigen-1 (BLCA-1) in Bladder Cancer.
Authors: Wang Z, Li H, Chi Q, Qiu Y, Li X, Xin L Abstract BACKGROUND The aim of this study was to determine the clinical significance of the expression levels of bladder cancer-specific antigen-1 (BLCA-1) in the diagnosis of bladder cancer (BC). The study also determined the relationship between BLCA-1 expression levels and the clinical manifestation of BC. MATERIAL AND METHODS Patient samples were derived from 66 cases of BC that presented at the Department of Urology, Affiliated Hospital of Chengde Medical University, were recruited from April 2014 to May 2015, and 64 healthy control cases. Serum and urine BLCA-1...
Source: Medical Science Monitor - June 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Systemic Inflammatory Response Syndrome (SIRS) and the Pattern and Risk of Sepsis Following Gastrointestinal Perforation.
Authors: Ye-Ting Z, Dao-Ming T Abstract BACKGROUND Systemic inflammatory response syndrome (SIRS) is characterized by systemic inflammation and tissue injury. Secondary sepsis is a common critical illness associated with poor clinical outcome. The aim of this study was to investigate the risk of SIRS-positive and SIRS-negative sepsis following gastrointestinal (GI) perforation. MATERIAL AND METHODS A retrospective study included 51 patients with GI perforation who had clinical evidence of sepsis, with or without SIRS. Clinical outcome was assessed at day 30 using the Glasgow Outcome Scale (GOS) (score, 1-5) and the...
Source: Medical Science Monitor - June 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Basic Parameters of Blood Count, Serum Sodium, and Creatinine as Prognostic Factors for Renal Cell Carcinoma at Five-Year Follow-Up.
CONCLUSIONS Preoperative PLT, serum sodium, and tumor staging were independent risk factors for local recurrence. Blood PLT, serum sodium, creatinine, and tumor staging were useful indicators for estimating 5-year cancer specific survival. PMID: 29885161 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Blood Lipid Profiles and Atrial Fibrillation: A Case-Control Study.
Authors: Li ZZ, Du X, Guo XY, Tang RB, Jiang C, Liu N, Chang SS, Yu RH, Long DY, Bai R, Sang CH, Li SN, Dong JZ, Ma CS Abstract BACKGROUND Dyslipidemia is the most frequent comorbidity in patients with cardiovascular disease. However, studies examining the relationship between blood lipid profiles and AF have produced inconsistent results. MATERIAL AND METHODS A total of 651 patients were enrolled into 3 groups: Healthy controls (n=64), Paroxysmal AF (PAF; n=270), and Continuous AF (CAF; n=317). All enrolled patients underwent routine baseline 12-lead electrocardiography (ECG) and 24-h dynamic ECG along with blood ...
Source: Medical Science Monitor - June 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats.
Authors: Yan W, Chen T, Long P, Zhang Z, Liu Q, Wang X, An J, Zhang Z Abstract BACKGROUND Molecular hydrogen (H2) has been widely reported to have benefiicial effects in diverse animal models and human disease through reduction of oxidative stress and inflammation. The aim of this study was to investigate whether hydrogen gas could ameliorate endotoxin-induced uveitis (EIU) in rats. MATERIAL AND METHODS Male Sprague-Dawley rats were divided into a normal group, a model group, a nitrogen-oxygen (N-O) group, and a hydrogen-oxygen (H-O) group. EIU was induced in rats of the latter 3 groups by injection of lipopolysacc...
Source: Medical Science Monitor - June 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Serum Inflammatory Markers in Patients with Adenovirus Respiratory Infection.
Authors: Sun J, Xiao Y, Zhang M, Ao T, Lang S, Wang J Abstract BACKGROUND The aim of this study was to characterize adenovirus-associated acute respiratory infection (ARI) and observe correlations between inflammatory markers and severity of human adenovirus type 7 (HAdV-7) infection, and to evaluate the potential of inflammatory markers to predict progression from upper-respiratory infection (URI) to adenovirus pneumonia (AdP). MATERIAL AND METHODS A total of 81 patients with adenovirus-associated ARI and confirmed HAdV-7 infection were enrolled. Cases were classified according to severity, as AdP and URI. Demogra...
Source: Medical Science Monitor - June 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Cryptochrome 2 (CRY2) Suppresses Proliferation and Migration and Regulates Clock Gene Network in Osteosarcoma Cells.
CONCLUSIONS Our results suggest that CRY2 may be an anti-oncogene in OS, whose functions involve both downstream genes and other circadian genes. PMID: 29879092 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Xylosyltransferase-I Silencing on Implanting Growth of Salivary Pleomorphic Adenoma.
CONCLUSIONS XT-I gene silencing effectively inhibited the implanting growth of SPA. PMID: 29867072 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Mean Platelet Volume, C-Reactive Protein, and Prognosis in Patients with Acute Ischemic Stroke Following Intravenous Thrombolytic Treatment.
CONCLUSIONS MPV and CRP values were significantly associated with improvement in the NIH Stroke Scale and MRS scores in AIS when patients were treated with IV thrombolytic therapy within 4.5 hours of the onset of symptoms. PMID: 29869620 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Sirtuin-1 on Synaptic Plasticity in Nucleus Accumbens in a Rat Model of Heroin Addiction.
This study investigated the relationship between synaptic plasticity and changes in addictive behavior and examined the expression of synaptic plasticity-associated proteins and genes in the nucleus accumbens (NAc) region in different rat models. MATERIAL AND METHODS Heroin addiction, SIRT1-overexpression, and SIRT1-silenced rat models were established. Polymerase chain reaction gene chip technology, immunohistochemistry, Western blotting, and transmission electron microscopy were used to detect changes in synaptic plasticity-related gene and protein expression, and changes in the ultrastructure of synapses, in the NAc. RE...
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH).
CONCLUSIONS Melatonin provided protection from the effects of EBI following SAH by regulating the expression of murine SIRT3. PMID: 29872034 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Natural Diterpenoid Isoferritin A (IsoA) Inhibits Glioma Cell Growth and Metastasis via Regulating of TGF β-Induced EMT Signal Pathway.
CONCLUSIONS Results indicate that IsoA could be regarded as a potential anti-cancer agent by regulating TGFβ-induced EMT signal pathway. PMID: 29873321 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA Small Nucleolar RNA Host Gene 1 (SNHG1) Promotes Renal Cell Carcinoma Progression and Metastasis by Negatively Regulating miR-137.
CONCLUSIONS SNHG1 is significantly upregulated in RCC and renal cancer cell lines. Overexpression of SNHG1 participates in RCC tumorigenesis by regulating miR-137. PMID: 29874202 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Type A Behavior Pattern, Impulsiveness, Risk Propensity, and Empathy as Predictors of Dyspnea and Number of Infections in Men with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.
CONCLUSIONS Type A behavior pattern and risk propensity are independent predictors of the number of infections in the last year and of the subjective severity of dyspnea among men with COPD and healthy male smokers. PMID: 29874681 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Impact of the Use of Kinesio Taping Method on the Reduction of Swelling in Patients After Orthognathic Surgery: A Pilot Study.
Authors: Lietz-Kijak D, Kijak E, Krajczy M, Bogacz K, Łuniewski J, Szczegielniak J Abstract BACKGROUND Orthognathic surgery (OGS) is associated with extensive surgical intervention within the soft and hard tissues of the facial region of the skull leading to inflammatory reactions. The presence of postoperative swelling indicates the accumulation of exudate or transudate; both these fluids occur in surgery. Massive swelling is a significant problem, because the tension of tissues intensifies pain sensations. The aim of the study was to evaluate the effectiveness of the kinesio taping method (KT) in patients after ...
Source: Medical Science Monitor - June 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research