Correlation Between von Hippel-Lindau Gene Expression and Tumor SUVmax and Survival Prognosis in Hepatocellular Carcinoma.
Authors: Li G, Shen Y, Wang F, Hong S, Cai M Abstract BACKGROUND We investigated the relationship between the 18F-FDG PET/CT metabolic parameter SUVmax in primary hepatocellular carcinoma (HCC) and expression of von Hippel-Lindau (VHL), as well as its effect on HCC survival prognosis. MATERIAL AND METHODS We retrospectively analyzed data for 62 HCC patients who received 18F-FDG PET/CT before surgery at the First Affiliated Hospital of Bengbu Medical College from June 2013 to June 2018 (42 males, 20 females; median age 62 years). No treatment was performed prior to the examination. The relationship between preoperat...
Source: Medical Science Monitor - February 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

LOC101060264 Silencing Suppresses Invasion and Metastasis of Human Colon Cancer.
CONCLUSIONS In summary, LOC101060264 silencing decreased LoVo cell invasiveness via suppressing ETM and attenuated tumor metastasis, which provides a novel therapeutic target for patients with colon cancer. PMID: 32077446 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Antimicrobial Efficacy of Different Decontamination Methods as Tested on Dental Implants with Various Types of Surfaces.
CONCLUSIONS The results of our study suggest that the method of implant decontamination should be customized to the type of implant surface. PMID: 32078588 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 22, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Circular RNA-0001283 Suppresses Breast Cancer Proliferation and Invasion via MiR-187/HIPK3 Axis.
CONCLUSIONS The results reveal a new functional circRNA-0001283 in breast cancer and may provide targets for developing novel therapeutic strategies for breast cancer. PMID: 32066649 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Usefulness of a Nurse-Led Program of Care for Management of Patients with Chronic Heart Failure.
Authors: You J, Wang S, Li J, Luo Y Abstract BACKGROUND The aims of the present study were to determine whether a nurse-led program of care can improve medication adherence, quality of life (QoL), rates of rehospitalization, and all-cause mortality for chronic heart failure (CHF) patients. MATERIAL AND METHODS CHF patients were randomly assigned into either a control group or an intervention group. At 12 weeks, patients were followed up to evaluate the rate of medication adherence, QoL (as assessed by SF-12 physical and mental component score [PCS and MCS]), rehospitalization, and all-cause mortality. RESULTS We re...
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy.
CONCLUSIONS The current study indicated that patients with lung cancer after CTx had decreased dynamic brain activity in the DMN region, and the DMN is vulnerable when patients undergoing CTx. PMID: 32069270 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Role of Ca ²⁺ in Inhibiting Ischemia-Induced Apoptosis of Parathyroid Gland Cells in New Zealand White Rabbits.
CONCLUSIONS This study demonstrates that calcium supplementation inhibited the apoptosis of parathyroid cells following ischemic injury. PMID: 32071284 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1 α).
CONCLUSIONS Our results demonstrate that miR-411 promotes chondrocyte autophagy by targeting HIF-1alpha, suggesting that regulating HIF-1alpha by miR-411 might be a therapeutic strategy for OA. PMID: 32072994 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Development of a Nomogram for Predicting Blood Transfusion Risk After Hemiarthroplasty for Femoral Neck Fractures in Elderly Patients.
CONCLUSIONS We found a correlation between blood transfusion requirement and low preoperative Hb, longer time to surgery, general anesthesia, longer surgery duration, and higher IBL, and we then developed a nomogram. Our nomogram model can be used to evaluate the transfusion risk for FNF patients after HA, and provides better guidance for clinicians to intervene perioperatively, so as to reduce the incidence of blood transfusion. PMID: 32074099 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Hetiao Jianpi Decoction on Intestinal Injury and Repair in Rats with Antibiotic-Associated Diarrhea.
CONCLUSIONS By improving the permeability and immune function of the intestinal mucosa, Hetiao Jianpi decoction prevented the occurrence of AAD by repairing the intestinal mucosal damage and regulating the structure and diversity of intestinal flora. PMID: 32062668 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association Between Cystatin C and Cardiac Function and Long-Term Prognosis in Patients with Chronic Heart Failure.
Authors: Wu X, Xu G, Zhang S Abstract BACKGROUND The aim of this study was to investigate the association between cystatin C and cardiac function and long-term prognosis in patients with chronic heart failure (CHF). MATERIAL AND METHODS We selected 418 CHF patients admitted to our hospital as subjects. Patients were divided into 3 groups according to the cystatin C level (Quantile 1 group: 0.65-1.04 mg/L, Quantile 2 group: 1.05-1.35 mg/L, and Quantile 3 group: 1.36-7.84 mg/L), and patients were followed up for 5 years. We used odds ratio (OR) and 95% confidence interval (CI) to compare the results. RESULTS The cyst...
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.
Authors: Wei L, Chen J, Wen J, Wu D, Ma X, Chen Z, Huang J Abstract BACKGROUND The aim of this study was to perform an accurate exploration on the efficacy of oxaliplatin/5-fluorouracil/capecitabine-cetuximab combination therapy and its effects on K-Ras mutations in advanced colorectal cancer. MATERIAL AND METHODS Among 96 patients who suffered metastatic colorectal cancer without mutated K-Ras, 41 patients who were receiving treatment with oxaliplatin/5-fluorouracil/capecitabine and administered cetuximab as the initial treatment comprised the observation group; the remaining 55 patients receiving cetuximab as an ...
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Inositol Metabolism in Pregnant Women on Offspring in the North and South of China.
Authors: Wang X, Yue H, Li S, Guo J, Guan Z, Qin J, Zhu Z, Niu B, Cui M, Wang J Abstract BACKGROUND Inositol is an essential nutrient for cell growth, survival and embryonic development. Myo-inositol is the predominant form in natural. To investigate the correlation between inositol metabolism and embryonic development, we assessed the metabolic characteristics of myo-inositol, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P₃) of pregnant women in the North China (Yangquan and Weihai) and South China (Nanchang and Haikou) China. MATERIAL AND METHODS All...
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Huai Qi Huang Potentiates Dexamethasone-Mediated Lethality in Acute Lymphoblastic Leukemia Cells by Upregulating Glucocorticoid Receptor α.
CONCLUSIONS HQH enhanced the sensitivity of ALL cells to glucocorticoids by increasing the expression of GRalpha and inhibiting the MEK/ERK pathway, thus providing a rational foundation for the treatment of ALL with HQH. PMID: 32065117 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Total Flavonoid Extract from Hawthorn (Crataegus pinnatifida) Improves Inflammatory Cytokines-Evoked Epithelial Barrier Deficit.
CONCLUSIONS TFH can alleviate TNF-alpha-evoked intestinal epithelial barrier deficit via the NFkappaBp65-mediated MLCK-MLC signaling pathway. PMID: 32065826 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 19, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Impact of Sevoflurane Versus Propofol Anesthesia on Post-Operative Cognitive Dysfunction in Elderly Cancer Patients: A Double-Blinded Randomized Controlled Trial.
CONCLUSIONS Sevoflurane-based anesthesia did not increase the incidence of POCD compared to propofol-based anesthesia at 7 days or 3 months post-operation or impact short-term post-operative prognosis. PMID: 32060257 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Network Pharmacology-Based Prediction and Verification of Qingluo Tongbi Formula to Reduce Liver Toxicity of Tripterygium wilfordii via UGT2B7 in Endoplasmic Reticulum.
CONCLUSIONS The Chinese traditional medicine compound QTF can achieve the effect of detoxification by upregulating the expression of UGT2B7 in the endoplasmic reticulum. PMID: 32061080 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT.
CONCLUSIONS Inhibition of miR-122 can decrease cerebral ischemia-reperfusion injury by upregulating DJ-1-PTEN/PI3K/AKT pathway. PMID: 32061171 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway.
CONCLUSIONS GANT61 and valproic acid inhibited multiple myeloma cell proliferation synergistically by inhibiting the Hedgehog signaling pathway. The present study may provide a combination regime for the therapy of multiple myeloma. PMID: 32054823 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA X-Inactive Specific Transcript (XIST) Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells by Sponging MicroRNA-214-3p.
CONCLUSIONS XIST participates in osteogenic differentiation of PDLSCs by sponging miR-214-3p. PMID: 32057034 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes and Pathways in Gastric Adenocarcinoma Based on Bioinformatics Analysis.
CONCLUSIONS This research distinguished hub genes and relevant signal pathways, which contributes to our understanding of the molecular mechanisms, and could be used as diagnostic indicators and therapeutic biomarkers for gastric adenocarcinoma. PMID: 32058995 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 16, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Management of Infected Bone Defects of the Lower Extremities by Three-Stage Induced Membrane Technique.
CONCLUSIONS TSIMT is effective in treating infected bone defects of the lower extremities. Advanced age, longer duration of infected bone defects, active smoking, and external fixation adversely affect bone union and recovery of infected extremities in a limited time span. PMID: 32047141 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
CONCLUSIONS IL-36R deficiency in cardiomyocytes repressed infiltration of bone marrow-derived inflammatory cells and oxidative stress dependent on SIRT1-FOXO1 signaling, thus protecting cardiomyocytes and improving cardiac function in CPB model rats. PMID: 32048631 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Downregulation of MiR-218-5p Protects Against Oxygen-Glucose Deprivation/Reperfusion-Induced Injuries of PC12 Cells via Upregulating N-myc Downstream Regulated Gene 4 (NDRG4).
CONCLUSIONS Downregulation of miR-218-5p protect against OGDR-induced injuries of PC12 cells through reducing inflammatory cytokines secretion, oxidative stress status, apoptosis rate and maintenance of endovascular homeostasis via upregulating NDRG4. MiR-218-5p may serve as a novel effective biomarker to monitor AIS progression. PMID: 32048632 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Integrative Analysis of Long Non-Coding RNAs (lncRNAs), miRNAs, and mRNA-Associated ceRNA Network in Lung Tissue of Aging Mice and Changes After Treatment with Codonopsis pilosula.
CONCLUSIONS Our results showed that Codonopsis pilosula has a protective effect on the aging lung, and the ceRNA network plays an important role in the anti-aging effect of Codonopsis pilosula. PMID: 32049955 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Grilled Nux Vomica on Differential RNA Expression Profile of Gastrocnemius Muscle and Toll ‑Like Receptor 4 (TLR-4)/Nuclear Factor kappa B (NF-κB) Signaling in Experimental Autoimmune Myasthenia Gravis Rats.
CONCLUSIONS These results indicate that grilled nux vomica ameliorates EAMG by depressing the TLR-4/NF-kappaB signaling pathway, and hub genes may serve as potential targets for MG treatment. PMID: 32052794 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (LncRNA) CASC15 Is Upregulated in Diabetes-Induced Chronic Renal Failure and Regulates Podocyte Apoptosis.
CONCLUSIONS Therefore, CASC15 is upregulated in DCRF patients and promotes the apoptosis of podocytes by sponging miR-34c. Our study adds to our understanding of the pathogenesis of DCRF and suggests that CASC15 could serve as a potential therapeutic target of DCRF. PMID: 32053576 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Pleuromutilin Inhibits Proliferation and Migration of A2780 and Caov-3 Ovarian Carcinoma Cells and Growth of Mouse A2780 Tumor Xenografts by Down-Regulation of pFAK2.
This study aimed to investigate the effects of pleuromutilin on migration and proliferation of A2780 and Caov-3 human ovarian carcinoma cells and the growth of A2780 tumor xenografts in mice and the molecular mechanisms involved. MATERIAL AND METHODS A2780 and Caov-3 human ovarian carcinoma cells were cultured with and without 40, 160, and 200 μM of pleuromutilin. The Edu fluorescence assay, the wound-healing assay, and Matrigel were used to measure A2780 and Caov-3 cell proliferation, migration, invasion, and adhesion in vitro, respectively. Western blot measured protein levels of FAK, p-FAK, MMP-2, and MMP-9. A2780 ce...
Source: Medical Science Monitor - February 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Value of Site-Specific Metastases and Surgery in De Novo Stage IV Triple-Negative Breast Cancer: A Population-Based Analysis.
Authors: Gu Y, Wu G, Zou X, Huang P, Yi L Abstract BACKGROUND This retrospective study aimed to evaluate the prognostic roles of distant metastatic patterns in de novo metastatic triple-negative breast cancer to explore the roles of surgery on the primary tumor and to characterize the prognostic factors of organ-specific metastasis. MATERIAL AND METHODS Data were obtained from the Surveillance, Epidemiology, and End Results program. Kaplan-Meier analyses and log-rank tests were employed to compare survival outcomes among variables. The Cox proportional hazards model was used to assess risk factors for survival. The...
Source: Medical Science Monitor - February 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control.
CONCLUSIONS To our best knowledge, this study is the first regarding the effects of an injection method in the treatment of osteoarthritis secondary to DDH. According to our study, PrT is superior to exercises. PrT could provide significant improvement for clinical outcomes in DDH and might delay surgery. PMID: 32045406 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Ginsenoside Rg1 Inhibits Cell Proliferation and Induces Markers of Cell Senescence in CD34+CD38- Leukemia Stem Cells Derived from KG1 α Acute Myeloid Leukemia Cells by Activating the Sirtuin 1 (SIRT1)/Tuberous Sclerosis Complex 2 (TSC2) Signaling Pathway.
This study aimed to investigate the effects of the ginseng derivative, ginsenoside Rg1 (Rg1), on CD34+CD38- LSCs derived from KG1a human acute myeloid leukemia cells. MATERIAL AND METHODS CD34+CD38- LSCs were isolated from KG1a human acute myeloid leukemia cells by cell sorting. CD34+CD38- KG1alpha LSCs were divided into the control group and the Rg1 group (treated with Rg1). The cell counting kit-8 (CCK-8) assay evaluated the proliferation of CD34+CD38- KG1alpha LSCs and flow cytometry studied the cell cycle. The mixed colony-forming unit (CFU-Mix) assay and staining for senescence-associated beta-galactosidase (SA-ß...
Source: Medical Science Monitor - February 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Peripheral Blood Leukocyte RNA-Seq Identifies a Set of Genes Related to Abnormal Psychomotor Behavior Characteristics in Patients with Schizophrenia.
CONCLUSIONS The findings enhance our understanding of the biological processes of schizophrenia, enabling us to identify specific clinical dimensions of genes for diagnosis and prognostic markers and possibly for targeted therapy. PMID: 32038049 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Resveratrol Reduces Kidney Injury in a Rat Model of Uremia and is Associated with Increased Expression of Heat Shock Protein 70 (Hsp70).
This study aimed to investigate the effects of resveratrol on kidney function in a rat model of uremia and the expression of heat shock proteins. MATERIAL AND METHODS The rat model of uremia was developed by 5/6 nephrectomy of Sprague-Dawley rats. The Hsp70 inhibitor MKT-077, a rhodacyanine dye, was used. The study groups included rats with sham surgery (the sham group), the rat model of uremia (the model group), the solvent-treated control group (the control group), the rat model treated with resveratrol group (the resveratrol group), the rat model treated with MKT-077 (the MKT-077 group), and the resveratrol+MKT-077 grou...
Source: Medical Science Monitor - February 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Dexmedetomidine in a Rat Model of Sepsis-Induced Lung Injury are Mediated Through the Adenosine Monophosphate-Activated Protein Kinase (AMPK)/Silent Information Regulator 1 (SIRT1) Pathway.
This study aimed to investigate the effects of dexmedetomidine in a rat model of sepsis-induced lung injury and the role of the adenosine monophosphate-activated protein kinase (AMPK) gene and silent information regulator 1 (SIRT1) gene signaling pathway. MATERIAL AND METHODS Sixty 28-week-old healthy male Sprague-Dawley rats were randomly divided into three groups, the sham group, the model group, and the dexmedetomidine-treated group. The rat model of sepsis-induced lung injury was developed by surgical cecal ligation and puncture. Lung tissues examined histologically in the three study groups. Cell apoptosis was measure...
Source: Medical Science Monitor - February 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Potential Role of Integrin α₅β₁/Focal Adhesion Kinase (FAK) and Actin Cytoskeleton in the Mechanotransduction and Response of Human Gingival Fibroblasts Cultured on a 3-Dimension Lactide-Co-Glycolide (3D PLGA) Scaffold.
CONCLUSIONS The integrin alpha₅ß₁/FAK signaling pathway and actin cytoskeleton appear to be involved in the mechanotransduction of HGFs. There could be other mechanisms involved in the promotion effect of mechanical force on collagen synthesis in addition to the integrin alpha₅ß₁ pathway. PMID: 32034900 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comprehensive Analysis of Differential Gene Expression to Identify Common Gene Signatures in Multiple Cancers.
This study aimed to identify the common gene expression characteristics of multiple cancers - lung cancer, liver cancer, kidney cancer, cervical cancer, and breast cancer - and the potential therapeutic targets in public databases. MATERIAL AND METHODS Gene expression analysis of GSE42568, GSE19188, GSE121248, GSE63514, and GSE66272 in the GEO database of multitype cancers revealed differentially expressed genes (DEGs). Then, GO analysis, KEGG function, and path enrichment analyses were performed. Hub-genes were identified by using the degree of association of protein interaction networks. Moreover, the expression of hub-g...
Source: Medical Science Monitor - February 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of (11R)-13-(6-Nitroindazole)-11,13-Dihydroludartin on Human Prostate Carcinoma Cells and Mouse Tumor Xenografts.
This study aimed to investigate the effects of the 6-nitroindazole compound and amino analog of ludartin, (11R)-13-(6-nitroindazole)-11,13-dihydroludartin (NDHL), on human prostate carcinoma cells in vitro and in mouse tumor xenografts in vivo. MATERIAL AND METHODS DU-145 and LNCaP human prostate carcinoma cells were cultured with increasing concentrations of NDHL. Cell viability was measured using the MTT assay, and cell apoptosis was measured by fluorescence flow cytometry. Mouse tumor xenografts were created by implanting 2×10⁶ of DU-145 cells subcutaneously in the left flank. On the second day following DU-145 ...
Source: Medical Science Monitor - February 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Small Nucleolar RNA Host Gene 1 (SNHG1) and Chromosome 2 Open Reading Frame 48 (C2orf48) as Potential Prognostic Signatures for Liver Cancer by Constructing Regulatory Networks.
CONCLUSIONS Our findings revealed that SNHG1 and C2orf48 possess potential prognostic value and should be considered as possible biomarkers for predicting clinical outcomes for patients with liver cancer. PMID: 32036380 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Basic Fibroblast Growth Factor (bFGF) Protects the Blood-Brain Barrier by Binding of FGFR1 and Activating the ERK Signaling Pathway After Intra-Abdominal Hypertension and Traumatic Brain Injury.
CONCLUSIONS bFGF effectively protected the BBB from damage caused by combined injury from IAH and TBI, and binding of FGFR1 and activation of the ERK signaling pathway was involved in these effects. PMID: 32036381 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Relationship Between Epicardial Adipose Tissue and Body Composition as Determined by Multi-Frequency Bioelectrical Impedance Analysis in Patients with Stage 5 Chronic Kidney Disease.
Authors: Yilmaz Z, İnce H, Aydin E, Yildirim Y, Yilmaz Aydin F, Yüksel E, Karabulut A, Dursun L, Kadiroğlu AK, Yilmaz ME Abstract BACKGROUND The main cause of mortality among chronic kidney disease (CKD) patients is cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is considered to be novel cardiovascular risk factor. We assessed EAT in non-dialyzed stage 5 CKD patients and explored the association of EAT with body composition as determined by multi-frequency BIA. MATERIAL AND METHODS The present included 70 stage 5 CKD patients who had not undergone dialysis and 40 healthy control subjects. EAT ...
Source: Medical Science Monitor - February 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Combined Use of Three Machine Learning Modeling Methods to Develop a Ten-Gene Signature for the Diagnosis of Ventilator-Associated Pneumonia.
CONCLUSIONS Logistic regression analysis, random forest analysis, and MLP analysis identified a ten-gene signature for the diagnosis of VAP. PMID: 32031163 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

SHOX CNE9/10 Knockout in U2OS Osteosarcoma Cells and Its Effects on Cell Growth and Apoptosis.
CONCLUSIONS Knockdown of CNE9 and CNE10 promoted U2OS cell growth and inhibited apoptosis by decreasing SHOX expression. This CNE9/CNE10 knockout U2OS cell model could provide a bridge for the research on SHOX and CNEs in osteosarcoma. PMID: 32032347 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 9, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis.
CONCLUSIONS Necrostatin-1 attenuated pulmonary fibrosis in lung tissues of BLM induced mice and inhibited the fibroblast proliferation. And, necrostatin-1 also decreased the expression of RIPK1, RIPK3, and ECM in lung tissues of BLM induced mice and TGF-ß induced fibroblasts. Necrostatin-1 could be a new effective drug for the treatment of IPF. PMID: 32019905 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Biomechanical Comparison of 1-Level Corpectomy and 2-Level Discectomy for Cervical Spondylotic Myelopathy: A Finite Element Analysis.
CONCLUSIONS Both ACDF and ACCF can provide satisfactory spinal stability. ACDF may be beneficial for subsidence resistance due to the lower stress peaks on the endplate. The ACCF may perform better in long-term stability and bone fusion owing to the lower stress peaks in the fixation system and bone-screw interfaces, and higher stress peaks in the bone graft. PMID: 32020914 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy.
CONCLUSIONS SMP is able to regulate glycometabolism-related, lipid metabolism-related, inflammatory response-related, oxidative stress-related signaling pathways, and biological processes and targets, which suggests that SMP may have a therapeutic effect on DCM. PMID: 32023237 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Remote Ischemic Preconditioning Ameliorates Renal Fibrosis After Ischemia-Reperfusion Injury via Transforming Growth Factor beta1 (TGF- β1) Signalling Pathway in Rats.
CONCLUSIONS Enhanced RIPC ameliorated renal fibrosis after IRI in rats, which appears to be associated with inhibition of the TGF-ß1/p-Smad2/3 signalling pathway. PMID: 32024811 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
CONCLUSIONS In a mouse model of NAFLD, RKI-1447 inhibited ROCK and modulated insulin resistance, oxidative stress, and inflammation through the ROCK/TLR4/TBK1/IRF3 pathway. PMID: 32026851 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of Long Noncoding RNA (lncRNA) AK094457 Relieved Angiotensin II Induced Vascular Endothelial Cell Injury.
CONCLUSIONS All these results indicated that lncRNA AK094457 could promote Ang II-induced vascular endothelial cell injury. On the contrary, knockdown of lncRNA AK094457 could alleviate this damage. PMID: 32027625 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways.
CONCLUSIONS Overall, miR-323-3p was considered a lung cancer oncogene and could be a valuable target for NSCLC therapy. PMID: 32009129 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of Long Non-Coding RNA (lncRNA) Colon Cancer-Associated Transcript-1 (CCAT1) Suppresses Oral Squamous Cell Carcinoma Proliferation, Invasion, and Migration by Inhibiting the Discoidin Domain Receptor 2 (DDR2)/ERK/AKT Axis.
CONCLUSIONS Downregulation of CCAT1 suppressed TCA-8113 cell proliferation, invasion, and migration by inactivation of the ERK/AKT pathway via inhibition of DDR2, suggesting the value of CCAT1 in diagnosis and treatment of patients with OSCC. PMID: 32009633 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 6, 2020 Category: Research Tags: Med Sci Monit Source Type: research