Diagnostic Value Comparison of Urothelium Carcinoma Among Urine Exfoliated Cells Fluorescent In Situ Hybridization (FISH) Examination, Computerized Tomography (CT) Scan, and Urine Cytologic Examination.
This study aimed to compare the clinical effectiveness of urine exfoliated cells FISH examination, CT scan, and urine cytologic examination on the diagnosis of upper urinary tract urothelium carcinoma with hematuresis symptom. MATERIAL AND METHODS A total of 30 patients with suspicious upper urinary tract urothelium carcinoma between Aug 2010 and Aug 2011 were enrolled, including 23 males and 7 females. All the subjects received urine exfoliated cells FISH examination, CT scan, and urine cytologic examination. Twenty-one cases were diagnosed as urothelium carcinoma, including 14 cases of carcinoma of renal pelvis and 7 cas...
Source: Medical Science Monitor - August 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Neuregulin-1 (NRG-1) Gene Contributes to Surgical Repair of Brachial Plexus Injury After Contralateral C7 Nerve Root Transfer in Rats.
CONCLUSIONS These results demonstrated that NRG-1 can promote recovery of nerve function in brachial plexus injury after contralateral C7 nerve root transfer in rats. PMID: 30121695 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 20, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Correlation of Brain Perfusion with White Matter Hyperintensity, Brain Atrophy, and Cognition in Patients with Posterior Cerebral Artery Stenosis and Subjective Cognitive Decline.
This study aimed to investigate the correlation of brain perfusion with white matter hyperintensity (WMH), brain atrophy, and cognition in patients with moderate to severe posterior cerebral artery stenosis (PCAS). MATERIAL AND METHODS 65 patients with memory decline as the main complaint and no history of brain infarction were recruited from the Department of Neurology of Tongji Hospital. Patients with moderate to severe PCAS were included in case group, and subjects with normal intracranial blood vessels served as controls. The demographics and vascular risk factors were recorded. Montreal Cognitive Assessment (MoCA) was...
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Increased Expression of CD81 in Breast Cancer Tissue is Associated with Reduced Patient Prognosis and Increased Cell Migration and Proliferation in MDA-MB-231 and MDA-MB-435S Human Breast Cancer Cell Lines In Vitro.
Authors: Zhang N, Zuo L, Zheng H, Li G, Hu X Abstract BACKGROUND CD81, a member of the tetraspanin family, is overexpressed in several tumor types, but its role in breast cancer remains unknown. The present study aimed to investigate the effects of increased CD81 expression on cell migration and proliferation in breast cancer cell lines, MDA-MB-231 and MDA-MB-435S in vitro, and the effects of increased CD81 expression in breast cancer tissue microarrays on patient prognosis. MATERIAL AND METHODS The expression of CD81 was evaluated using immunohistochemistry in a human breast cancer tissue microarray containing 140...
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of C-X-C Motif Chemokine 10 (CXCL10) Protects Mice from Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease.
CONCLUSIONS Inhibited CXCL10 protects against COPD progression by decreasing secretion of inflammatory factors, which provides a new direction for the clinical prevention and treatment of COPD. PMID: 30118441 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA HULC Promotes Progression of Bone Neoplasms.
CONCLUSIONS LncRNA HULC can promote the tumorigenesis of bone neoplasms through increasing the proliferation, invasion, and migration abilities and the expression level of EMT-related factors. PMID: 30120220 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Rehabilitation on Fatigue Level in Patients with Multiple Sclerosis.
The objective of this study was to evaluate the effect of a rehabilitation program in changing the perception of fatigue in patients with multiple sclerosis. MATERIAL AND METHODS The study involved 65 respondents/patients with clinically confirmed multiple sclerosis (54 women, 11 men, average age 46.49 years). The evaluation of the effects of fatigue on the physical, psychological, and psychosocial aspects of life was assessed using the Modified Fatigue Impact Scale (MFIS). To test the effectiveness of the neurorehabilitation program, we enrolled 2 groups: the experimental group (EG, n=32, 29 women, 3 men, Expanded Disabil...
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Integrative Bioinformatics Analysis Reveals Potential Long Non-Coding RNA Biomarkers and Analysis of Function in Non-Smoking Females with Lung Cancer.
Authors: Qiao F, Li N, Li W Abstract BACKGROUND Lung cancer is the most lethal cancer worldwide. The aim of this study was to identify the tumor-related lncRNAs and explore their functions in female non-smokers with lung cancer. MATERIAL AND METHODS The gene expression microarray datasets GSE19804, GSE31210, and GSE31548 were downloaded from the Gene Expression Omnibus database. The differentially-expressed lncRNAs between non-smoking female lung cancer samples and non-tumor lung tissues were identified using GEO2R. RESULTS In total, 25, 40, and 15 differentially-expressed lncRNAs were obtained from GSE19804, GSE31...
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1.
CONCLUSIONS Circ-CFH promotes glioma progression by sponging miR-149 and regulating the AKT1 signaling pathway. The circ-CFH/miR-149/AKT1 regulation axis may be a potential target for glioma therapy. PMID: 30111766 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Increased Concentrations of Extracellular Histones in Patients with Tuberculous Pleural Effusion.
CONCLUSIONS These results suggest that high concentrations of extracellular histones are markedly present in TPE, which may play an inflammatory role towards the progression of tuberculosis. PMID: 30113021 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research

A Predictive Risk Scoring System for Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy.
CONCLUSIONS This 6-point risk scoring system will be useful for perioperative risk management of CR-POPF. PMID: 30113999 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 18, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Short Implants and Conventional Implants in The Residual Maxillary Alveolar Ridge: A 36-Month Follow-Up Observation.
CONCLUSIONS Short implants can be successfully used to support single crowns in the lateral part of the maxilla. PMID: 30104560 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Six-Week Pelvic Floor Muscle Activity (sEMG) Training in Pregnant Women as Prevention of Stress Urinary Incontinence.
CONCLUSIONS The results indicate that a 6-week training process influences PFM EMG activity in pregnant women. During Q, the value of PFM activity after a training session tended to increase in the symptomatic and control groups, but in the symptomatic group it remains practically unchanged. Our results show the probable process of decreasing control of PFM activity during long-lasting contractions in symptomatic and control women. The comparison of BASE before and after training averaged the values of R after five 10-s contractions and showed an increase in the Base and decrease in the R. PMID: 30106065 [PubMed - in p...
Source: Medical Science Monitor - August 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

High Interleukin-37 (IL-37) Expression and Increased Mucin-Domain Containing-3 (TIM-3) on Peripheral T Cells in Patients with Rheumatoid Arthritis.
CONCLUSIONS Both pro-inflammatory cytokines (TNF-α and IL-6) and anti-inflammatory mediators (TIM-3 and IL-37) simultaneously contribute to the pathogenesis of RA. TIM-3 and IL-37 may be used as potential biomarkers of active RA. PMID: 30106887 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Deciphering Key Pharmacological Pathways of Qingdai Acting on Chronic Myeloid Leukemia Using a Network Pharmacology-Based Strategy.
In this study, we investigated the pharmacological mechanisms of Qingdai in the treatment of CML using network pharmacology approaches. First, components in Qingdai that were selected by pharmacokinetic profiles and biological activity predicted putative targets based on a combination of 2D and 3D similarity measures with known ligands. Then, an interaction network of Qingdai putative targets and known therapeutic targets for the treatment of chronic myeloid leukemia was constructed. By calculating the 4 topological features (degree, betweenness, closeness, and coreness) of each node in the network, we identified the candi...
Source: Medical Science Monitor - August 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Interaction Between Environmental Risk Factors and Catechol-O-Methyltransferase (COMT) and X-Ray Repair Cross-Complementing Protein 1 (XRCC1) Gene Polymorphisms in Risk of Lung Cancer Among Non-Smoking Chinese Women: A Case-Control Study.
CONCLUSIONS Taken together, T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women, with the factors of occupation type, cooking-oil fumes, and soot exposures representing key contributing factors. PMID: 30109864 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Correlation Between Apolipoprotein M and Inflammatory Factors in Obese Patients.
Authors: Li T, Yang L, Zhao S, Zhang S Abstract BACKGROUND The aim of this study was to observe apolipoprotein M (ApoM) level in obese patients and to explore its correlation with inflammatory factors. MATERIAL AND METHODS A total number of 96 participants were recruited and divided into 2 groups: the control group (or healthy group) whose participants had normal body weight (n=58), and the obese group with all its participants diagnosed with obesity (n=38). Data on blood pressure, body weight, height, body mass index, diastolic function of brachial artery endothelium, fasting venous blood glucose, blood lipids, pl...
Source: Medical Science Monitor - August 16, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Risk of Intervertebral Disc Degeneration in Chinese Han Population: A Case Control Study.
CONCLUSIONS Our study suggests that rs1121980 can become a biomarker for the screening and prognosis of IDD. The 2 haplotype blocks and 5 SNP-SNP combinations that we discovered might be indicative of the onset of IDD. Therefore, our study might serve as evidence for future IDD molecular diagnosis. PMID: 30099472 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Evaluation of Sexual Function in Women with Hypogonadotropic Hypogonadism Using the Female Sexual Function Index (FSFI) and the Beck Depression Inventory (BDI).
Authors: Barut MU, Çoksüer H, Sak S, Bozkurt M, Ağaçayak E, Hamurcu U, Kurban D, Eserdağ S Abstract BACKGROUND Hypogonadotropic hypogonadism (HH), or secondary hypogonadism, results from reduced secretion of gonadotropins, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH), by the pituitary gland, resulting in lack of production of sex steroids. The aim of this study was to evaluate self-reported sexual function in sexually active women with and without HH using two evaluation methods, the Female Sexual Function Index (FSFI) and the Beck Depression Inventory (BDI). MATERI...
Source: Medical Science Monitor - August 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Are There Differences in the Management of Acute Pancreatitis Cases Due to Severe Hypertriglyceridemia in Pregnant Women?
CONCLUSIONS The treatment of hypertriglyceridemia-induced acute pancreatitis was mostly confined to supportive, palliative treatments. However, plasmapheresis is a possible treatment option and should be used in the early stages of this disease. The response to medical treatment and support treatment was better in pregnant patients than in the other patient group, and pregnant patients did not require plasmapheresis. PMID: 30100601 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Resourcefulness Training on Symptoms Distress of Patients with Nasopharyngeal Carcinoma.
CONCLUSIONS The patients' benefit-finding and symptom distress were correlated with their resourcefulness. Resourcefulness training could enhance the level of resourcefulness and benefit-finding, palliate symptom distress, and promote disease rehabilitation in NPC patients during radiotherapy. PMID: 30101951 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells.
CONCLUSIONS In a transgenic mouse model of AD, miR-137 and expression of the CACNA1C gene inhibited the hyperphosphorylation of tau protein. PMID: 30102687 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 15, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Use of a New Nano-Hydroxyapatite/Polyamide66 Composite Artificial Lamina in Spinal Decompression Surgery: More Than 4 Years' Follow-Up.
Authors: Zhao Z, Guo L, Zhu Y, Luo W, Ou Y, Quan Z, Jiang D Abstract BACKGROUND Long-term follow-up results showed that epidural scar formation and adhesion after laminectomy always affected the outcomes of repeat operations. The establishment of a barrier between scar tissue and dura was effective in preventing epidural scar formation. MATERIAL AND METHODS A nano-hydroxyapatite/polyamide66 (n-HA/PA66) artificial lamina was designed and fabricated and used to cover the opened spinal canal in patients who received laminectomy. The visual analogue scale (VAS) and Japanese Orthopedic Association (JOA) Scores, X-ray, c...
Source: Medical Science Monitor - August 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Doxycycline Attenuates Atrial Remodeling by Interfering with MicroRNA-21 and Downstream Phosphatase and Tensin Homolog (PTEN)/Phosphoinositide 3-Kinase (PI3K) Signaling Pathway.
CONCLUSIONS CIH induced significant atrial remodeling, which was attenuated by doxycycline in our rat model. These changes may be explained due to alterations in the microRNA-21-related signaling pathways by doxycycline. PMID: 30098136 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF- κB Activation.
CONCLUSIONS We demonstrated that TLR4/COX-2 inhibits PCa cell proliferation, migration, and invasion by regulating NF-κB. PMID: 30098292 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Success Rate of Fungal Peri-Prosthetic Joint Infection Treated by 2-Stage Revision and Potential Risk Factors of Treatment Failure: A Retrospective Study.
CONCLUSIONS Debridement with the retention of the prosthesis is not an ideal treatment protocol for fungal peri-prosthetic joint infection; thus, a two-stage revision could be valid. We suggest that 6 weeks of parenteral antifungal agents are necessary, and 6 subsequent weeks of oral antifungal treatment is also important. We do not recommend that the two-stage revision be performed on patients who have more than 2 host risk factors. PMID: 30093606 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 12, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Contrast-Enhanced Ultrasound and Positron Emission Tomography/Computed Tomography (PET/CT) in Lymphoma.
CONCLUSIONS Quantitative CEUS data were correlated with PET-CT values, with potential use in the diagnosis of lymphoma. PMID: 30095086 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 12, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Relationship Between the Incidence of Road Traffic Accidents, Psychological Characteristics, and Genotype in Bus Drivers in a Chinese Population.
CONCLUSIONS Psychological characteristics associated with the 5-HTTLPR and DRD4-521 C/T genotypes, including extroversion, psychopathy, neuroticism, and time hurrying (impatience), and low serum levels of 5-HT and 5-HTP in bus drivers were associated with an increased risk of road traffic accidents. PMID: 30096132 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 12, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Use of Receiver Operating Characteristic (ROC) Curve Analysis for Tyrer-Cuzick and Gail in Breast Cancer Screening in Jiangxi Province, China.
CONCLUSIONS Both Gail model and Tyrer-Cuzick models can be used to evaluate breast cancer risk. The Gail model has relatively lower accuracy in evaluating breast cancer risk in Jiangxi province of China and the Tyrer-Cuzick model had relatively higher accuracy. PMID: 30089770 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Inhibition of Epidermal Growth Factor Receptor (EGFR) Reduces Lipopolysaccharide (LPS)-Induced Activation and Inflammatory Cytokines in Hepatic Stellate Cells In Vitro.
CONCLUSIONS Activation of HSCs by LPS in vitro, including the expression of inflammatory cytokines and mediators of fibrogenesis, were shown to be dependent on the expression of EGFR. PMID: 30091424 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Preoperative Assessment of Ultrasonographic Measurement of Antral Area for Gastric Content.
Authors: Kaydu A, Gokcek E Abstract BACKGROUND Pulmonary aspiration of the gastric contents is a serious perioperative complication. The aim of this study was to evaluate the efficacy of portable ultrasonography in the preoperative evaluation of the gastric contents of patients. The secondary aim was to examine the relationship between gastric antrum cross-sectional area and age and body mass index (BMI). MATERIAL AND METHODS This single-center, prospective, cross-sectional study included 120 patients who underwent surgery. Measurements the gastric antral cross-sectional areas and quantitative and qualitative measu...
Source: Medical Science Monitor - August 10, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Unilateral Electroacupuncture on Bilateral Proprioception in a Unilateral Anterior Cruciate Ligament Injury Model.
Authors: Xu J, Zhou X, Guo X, Wang G, Fu S, Zhang L Abstract BACKGROUND Anterior cruciate ligament (ACL) injury can cause knee proprioception degeneration, on which the electroacupuncture (EA) treatment has a definite effect. However, it is still not clear whether conducting EA intervention on the injured side can promote bilateral proprioception recovery. MATERIAL AND METHODS We randomly selected 6 of 9 normal cynomolgus monkeys to develop unilateral ACL injury models via arthroscopy. All knees were divided into 5 groups: the normal control (NC) group, injured side of blank model (ISBM) group, contralateral side o...
Source: Medical Science Monitor - August 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Girinimbine Inhibits the Proliferation of Human Ovarian Cancer Cells In Vitro via the Phosphatidylinositol-3-Kinase (PI3K)/Akt and the Mammalian Target of Rapamycin (mTOR) and Wnt/ β-Catenin Signaling Pathways.
CONCLUSIONS Girinimbine, a carbazole alkaloid used in Chinese herbal medicine, inhibited the proliferation and cell migration of human ovarian cancer cells in vitro, in a dose-dependent manner, via the PI3K/Akt/mTOR and Wnt/β-catenin signaling pathways. PMID: 30084434 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1.
CONCLUSIONS We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC. PMID: 30086127 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Targeting Interleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model.
CONCLUSIONS Our study indicates that IL-6 induces strong immunosuppression in the CRC microenvironment by recruiting immunosuppression cells and impairing T cell infiltration. Inhibition of IL-6 enhanced the efficacy of anti-PD-L1 in CRC, providing a novel strategy to overcome anti-PD-L1 resistance in CRC. PMID: 30087314 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

FSD-C10 Shows Therapeutic Effects in Suppressing oxidized low-density lipoprotein (ox-LDL)-Induced Human Brain Microvascular Endothelial Cells Apoptosis via Rho-Associated Coiled-Coil Kinase (ROCK)/Mitogen-Activated Protein Kinase (MAPK) Signaling.
CONCLUSIONS FSD-C10 increases cell viability in ox-LDL-treated BMECs by reducing cell apoptosis. ROCK/MAPKs-mediated apoptosis appears to be the underlying molecular mechanism. PMID: 30088495 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Different Cognitive Trainings on Amnestic Mild Cognitive Impairment in the Elderly: A One-Year Longitudinal Functional Magnetic Resonance Imaging (MRI) Study.
Authors: Feng W, Wang D, Tang L, Cheng Y, Wang G, Hu G, Gong X, Cao X, Jiang L, Li C Abstract BACKGROUND Cognitive training has been focused on the interventions of amnestic mild cognitive impairment (aMCI) in recent years, with poor understanding. MATERIAL AND METHODS The study participants with aMCI were screened in a previous intervention trial. Functional magnetic resonance imaging (fMRI) was adopted to investigate effects of single-domain cognitive training (SDCT) and multi-domain cognitive training (MDCT) on aMCI and to explore potential mechanisms. RESULTS There were significant differences in the grey matte...
Source: Medical Science Monitor - August 9, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Mimic Cochlear Implant Surgery-Induced Cochlear Infection Fails to Further Damage Auditory Pathway in Deafened Guinea Pigs.
CONCLUSIONS Mimic cochlear implant surgery-induced cochlear infection caused no significant damage to the auditory pathway in ototoxic drug-induced deafened guinea pigs. PMID: 30078839 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Improved Dermal Regeneration Using a Combination of Dermal Substitutes and Dermal Fibroblast Optimization: A Hypothesis.
Authors: Shi H, Weng T, Han C, Wang X Abstract In human adults, the repair of cutaneous wounds usually leads to scar formation rather than regeneration. Dermal substitutes have been used as a regenerative template for reducing scar formation and improving the extent of dermal regeneration. However, achievement of complete regeneration is still a long way off. Dermal substitutes are characterized by unusual regenerative activity, appearing to function by acting as temporary configurational guides for cell infiltration and synthesis of new stroma. Fibroblasts are important cells with many vital functions in wound-hea...
Source: Medical Science Monitor - August 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

The Prognostic Value of Expression of the Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) in Patients with Solid Malignant Tumors: A Systematic Review and Meta-Analysis.
Authors: Xiao B, Huang Z, Zhou R, Zhang J, Yu B Abstract BACKGROUND The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is expressed in solid malignant tumors. The aim of this systematic review and meta-analysis was to determine whether expression of the lncRNA SNHG1 was associated with prognosis in patients with malignancy. MATERIAL AND METHODS A literature review from Jan 1970 to July 2018 identified publications in the English language. Databases searched included: PubMed, OVID, Web of Science, the Cochrane Database, Embase, EBSCO, Google Scholar. Systematic review and meta-analysis were per...
Source: Medical Science Monitor - August 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of the Vaginal Microecological Status and Genital Tract Infection Characteristics of 751 Pregnant Women.
CONCLUSIONS The microecological status of pregnant women was basically the same as that of normal women. The most frequent genital tract infection was bacterial vaginosis. While bacterial vaginosis is amalgamative with vulvovaginal candidiasis and T. vaginalis infection, there was no significant difference in vaginal microecological observations among pregnant women in different age groups except that the non-albicans Candida infection incidence in the optimum reproductive age group and the T. vaginalis infection incidence in the younger age group was higher than in the other groups. PMID: 30065240 [PubMed - in process...
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Collagen Type VI Alpha 3 Chain Promotes Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Transforming Growth Factor β (TGF-β)/Smad Pathway.
CONCLUSIONS COL6A3 could influence the viability and angiogenesis of bladder cancer cells. COL6A3 may have a certain relationship with the TGF-β/Smad-induced EMT process. PMID: 30066698 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Selective Impairment of Attentional Networks of Executive Control in Middle-Aged Subjects with Type 2 Diabetes Mellitus.
CONCLUSIONS The ANT reveals significant impairment in the executive control of middle-aged patients diagnosed with T2DM, whereas no significant impairment was observed in the domains of alerting and orienting. PMID: 30067608 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Therapeutic Effect of Naloxone Combined with Hemodialysis on Acute Severe Alcoholism.
Authors: Wang G, Li Z, Li M, Liu S, Shan T, Liu J, Zhang Y Abstract BACKGROUND The aim of this research was to investigate the treatment effect of naloxone combined with hemodialysis on acute severe alcoholism. MATERIAL AND METHODS We included 36 patients treated with naloxone combined with hemodialysis in Group I and 34 patients treated with naloxone without hemodialysis in Group II. The Glasgow coma scale (GCS) score, the consciousness recovery time, alanine amino transferase (ALT) level, and complications were analyzed. RESULTS Mean GCS score in Group I was higher than that in Group II, with a significant difference (P
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Baicalein Protects Rats with Diabetic Cardiomyopathy Against Oxidative Stress and Inflammation Injury via Phosphatidylinositol 3-Kinase (PI3K)/AKT Pathway.
CONCLUSIONS Baicalein can protect DCM rats against damage from oxidative stress and inflammation in myocardial tissue, and PI3K/Akt signaling pathway may be involved to mediating these effects. PMID: 30070262 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of the KINDLIN-2 Gene and Reduced Expression of Kindlin-2 Affects Vascular Permeability in Angiogenesis in a Mouse Model of Wound Healing.
CONCLUSIONS In a mouse model of wound healing, KINDLIN-2 gene knockdown inhibited wound healing, and increased neovascular permeability in vivo. PMID: 30070977 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients.
CONCLUSIONS The increased levels of circulating Tang cells in LN patients might play a role in the balance of endothelium dysfunction in these patients. PMID: 30072685 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury.
CONCLUSIONS SC79 significantly increased Akt activation and reduced infarct volume and subsequently improved neurological function in ischemic brain after cerebral I/R injury in rats. These findings suggested that SC79 may be as a neuroprotective drug to be potentially used in the clinic. PMID: 30074018 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Assessment of the Cerebral Hemodynamic Benefits of Carotid Artery Stenting for Patients with Preoperative Hemodynamic Impairment Using Cerebral Single Photon Emission Computed Tomography (SPECT) and Carbon Dioxide Inhalation.
Authors: Chen DW, Zheng J, Shi J, Yin YW, Song C, Yang F, Zhang YQ, Ma LN Abstract BACKGROUND The aim of this study was to evaluate the effects of carotid artery angioplasty and carotid artery stenting (CAS) on cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in patients with preoperative cerebrovascular hemodynamic impairment. MATERIAL AND METHODS Seventeen patients with unilateral severe internal carotid artery (ICA) stenosis and ipsilateral CVR impairment underwent CAS. CBF and CVR were measured by single photon emission computed tomography (SPECT) with inhalation of carbon dioxide (CO2) one week b...
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Overnight Video-Polysomnographic Studies in Children with Intractable Epileptic Encephalopathies.
Authors: Nenadic-Baranasic N, Gjergja-Juraski R, Lehman I, Turkalj M, Nogalo B, Barisic N Abstract BACKGROUND The aim of this study was to assess sleep architecture and respiration during sleep in children with intractable epileptic encephalopathies using overnight video-polysomnography (V-PSG). MATERIAL AND METHODS Between 2015 to 2017 overnight V-PSG recordings were made for 31 children (22 boys and 9 girls) with intractable epileptic encephalopathy with a mean age of 6.78±3.61 years and a mean body mass index (BMI) of 15.83±3.16 kg/m3. Thirty-one healthy children were matched for sex, age, and BMI ...
Source: Medical Science Monitor - August 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research