Outcomes for Patients with Sepsis Following Admission to the Intensive Care Unit Based on Health Insurance Status: A Study from the Medical Information Mart for Intensive Care-III (MIMIC-III) Database.
Authors: Zhou Y, Yang D, Fu Q, Chen T, Chen Y, Zheng C Abstract BACKGROUND Previous research has focused on poor outcomes from a lack of insurance, but the effects of different types of insurance for patients with sepsis in the intensive care unit (ICU) have not been well studied. We aimed to investigate whether private health insurance was better than government-run health insurance in the United States in terms of clinical outcomes of patients with sepsis in the ICU. MATERIAL AND METHODS Patients with sepsis were identified from the Medical information Mart for Intensive Care-III database. Patients were grouped a...
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Short-Term Outcomes of Laparoscopic Duodenum-Preserving Total Pancreatic Head Resection Compared with Laparoscopic Pancreaticoduodenectomy for the Management of Pancreatic-Head Benign or Low-Grade Malignant Lesions.
CONCLUSIONS LDPPHRt is a time-saving procedure with short-term outcomes comparable to those of LPD for the management of benign or low-grade malignancies of the pancreatic head. PMID: 32935663 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Efficacy and Safety of Neuromuscular Blockade in Overweight Patients Undergoing Nasopharyngeal Surgery.
CONCLUSIONS For overweight patients undergoing nasopharyngeal surgery, the use of rocuronium with sugammadex had the shortest onset time of neuromuscular relaxation, accelerated the reversion of neuromuscular blockade, effectively reduced the occurrence of PORC, relieved postoperative pain, and maintained hemodynamic stability before extubation. The combination of rocuronium and sugammadex may be the best anesthetic regimen for overweight patients undergoing nasopharyngeal surgery. PMID: 32936790 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Comparison of Clinical Outcomes in Patients with ST Elevation Myocardial Infarction with Percutaneous Coronary Intervention and the Use of a Telemedicine App Before and After the COVID-19 Pandemic at a Center in Beijing, China, from August 2019 to March 2020.
CONCLUSIONS Telemedicine reduced the delay time of STEMI patients during the COVID-19 pandemic. The difference in short-term adverse clinical outcomes was not statistically significant between patients who used the app and those who did not. PMID: 32938901 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effects of Pulsatile Frequency of Left Ventricular Assist Device (LVAD) on Coronary Perfusion: A Numerical Simulation Study.
CONCLUSIONS This work provides a useful method to increase coronary perfusion and may be beneficial for improving myocardial function in patients with end-stage heart failure, especially those with ischemic cardiomyopathy (ICM). PMID: 32940255 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Cyclin G2 Is Involved in the Proliferation of Placental Trophoblast Cells and Their Interactions with Endothelial Cells.
CONCLUSIONS CCNG2 plays a critical role in trophoblast proliferation and trophoblast-endothelial cell interactions by significant affecting cell cycle, angiogenic, and invasive markers. CCNG2 may thus be a novel marker for the treatment of placental disorders. PMID: 32941407 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Cluster Analysis of the Associations among Physical Frailty, Cognitive Impairment and Mental Disorders.
CONCLUSIONS Clustering of physical and cognitive performances, based on combinations of their grades of severity, may be superior to modelling of their respective entities, including the continuity and non-linearity of age-related accumulation of pathologic conditions. PMID: 32929055 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Novel Multiple-Cue Observational Clinical Scale for Functional Evaluation of Gait After Stroke - The Stroke Mobility Score (SMS).
CONCLUSIONS The SMS proves to be an easy-to-use, tele-applicable, robust, consistent, reliable, and nuanced functional scale of gait impairments after stroke. Due to its sensitivity to whole-body motion criteria, it is ideally suited for machine learning algorithms and for development of new therapy strategies based on instrumented gait analysis. PMID: 32930152 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway.
CONCLUSIONS IL-37 can significantly reduce podocyte inflammation, oxidative stress, and apoptosis induced by high glucose, and can inhibit the STAT3-CypA signaling pathway. Upregulation of the STAT3-CypA signaling pathway can inhibit the protective effect of IL-37 against podocyte injury induced by high glucose. PMID: 32931486 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 17, 2020 Category: Research Tags: Med Sci Monit Source Type: research

AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model.
In this study we established experimental autoimmune myasthenia gravis (EAMG) rat models to investigate the effects of AEB-071 (AEB), which is a specific inhibitor of protein kinase C that prevents T lymphocyte activation. MATERIAL AND METHODS We utilized animals divided into 4 groups: (1) control rats, (2) EAMG, (3) AEB-071+EAMG, and (4) AZP+EAMG. Drug treatment was continued for 10 days. Ten weeks after immunization we measured body weights, assessed mortality rates, and used Lennon scores to evaluate EAMG grades. We also assessed the proportions of Treg, Th1, Th2, Th17, and lymphocytes using flow cytometry. RESULTS In t...
Source: Medical Science Monitor - September 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Nomogram for Predicting Breast Cancer-Specific Mortality of Elderly Women with Breast Cancer.
CONCLUSIONS We built a reliable dynamic nomogram for predicting BCSD in elderly patients, and this individualized predictive tool is favorable for risk classification and complex personalized treatment decision making in clinical practice. PMID: 32920589 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Celastrol Inhibits Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Interleukin-6 via Downregulating Nuclear Factor- κB (NF-κB).
CONCLUSIONS Celastrol repressed migration and invasion through decreasing IL-6 levels by inactivation of NF-kappaB signaling in triple-negative breast cancer cells, providing a novel basis for use of celastrol in treating triple-negative breast cancer. PMID: 32920591 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Do We Need to Distinguish Thrombolysis and Nonthrombolysis Patients When Applying Stroke-Associated Pneumonia Predicting Scores? An External Validation from a 2-Center Database.
Authors: Jiao J, Geng L, Zhang Z Abstract BACKGROUND Due to the lack of validation for predictive scoring of stroke-associated pneumonia in both thrombolysis- and nonthrombolysis-treated ischemic stroke (IS) patients, this study aimed to evaluate 4 scoring methods in the 2 subgroups. MATERIAL AND METHODS The CerebroVascular Database Project database included data from patients with cerebral IS that were admitted in 2 hospitals from February 2016 to January 2018. A total of 138 thrombolysis-treated and 138 nonthrombolysis-treated IS patients were enrolled. Area under receiver operating characteristic curves (AUROC) ...
Source: Medical Science Monitor - September 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Systematic Pharmacology and In Vitro Study to Identify the Role of the Active Compounds of Achyranthes bidentata in the Treatment of Osteoarthritis.
CONCLUSIONS Quercetin, baicalein, and berberine are the critical active compounds of Achyranthes bidentata in the treatment of OA. TNF, IL-6, and TP53 may be potential targets for the treatment of OA. PMID: 32925869 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Target Genes Related to Sulfasalazine in Triple-Negative Breast Cancer Through Network Pharmacology.
CONCLUSIONS Our analysis revealed that the main reasons for the inhibitory effect of SAS on TNBC cells may be inhibition of the inflammatory response and MMP family members and activation of ROS. PMID: 32925871 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 15, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The Effects of Online Homeschooling on Children, Parents, and Teachers of Grades 1-9 During the COVID-19 Pandemic.
CONCLUSIONS Students should continue the going-to-school rhythm at home to cope with changes caused by the COVID-19 pandemic. Integrated grade-specific approaches are needed. Because long screen time and insufficient outdoor activities can severely affect children's eyesight, appropriate eye-protection measures should be implemented. PMID: 32917849 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Use of Enhanced Recovery After Surgery (ERAS) in Laparoscopic Cholecystectomy (LC) Combined with Laparoscopic Common Bile Duct Exploration (LCBDE): A Cohort Study.
Authors: Zhang N, Wu G, Zhou Y, Liao Z, Guo J, Liu Y, Huang Q, Li X Abstract BACKGROUND The have been few reports on use of ERAS in LC combined with LCBDE to promote postoperative recovery of patients. Therefore, the purpose of this cohort study was to explore the use of ERAS in patients who underwent LC combined with LCBDE. MATERIAL AND METHODS We collected clinical data of 445 patients who underwent elective laparoscopic cholecystectomy combined with laparoscopic common bile duct exploration from January 2015 to February 2019 in our hospital and divided the patients into an E-LC group and an LC group. The stress ...
Source: Medical Science Monitor - September 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Radiological and Clinical Differences between Tinavi Orthopedic Robot and O-Arm Navigation System in Thoracolumbar Screw Implantation for Reconstruction of Spinal Stability.
Authors: Du J, Gao L, Huang D, Shan L, Wang W, Fan Y, Hao D, Yan L Abstract BACKGROUND Pedicle screw fixation is one of the most commonly used methods in spine surgery. We introduce a surgical robot system from China based on 3-dimensional fluoroscopy imaging and compare it with the commonly used O-arm navigation system. We study the differences in accuracy, safety, and clinical effect in auxiliary pedicle screw fixation. MATERIAL AND METHODS Patients who underwent thoracolumbar internal fixation in our hospital from 2017 to 2019 were divided into a robot and navigation group according to whether surgery was assist...
Source: Medical Science Monitor - September 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Prognostic Significance of CA125 Dynamic Change for Progression Free Survival in Patients with Epithelial Ovarian Carcinoma.
This study aimed to investigate the value of CA125 dynamic change in PFS prediction for patients with epithelial ovarian carcinoma (EOC). MATERIAL AND METHODS Data analysis was performed using SPSS 24.0 statistical software with progression-free survival (PFS) as an outcome measure. Kaplan-Meier method was used to analyze the relationship between PFS and preoperative and postoperative NLR, PLR and CA125 levels, CA125 half-life, CA125-negative time, age, FIGO stage, histopathology, differentiation, vessel carcinoma embolus, and ascites. The survival curves were compared by the log-rank test. Based on the results of single-f...
Source: Medical Science Monitor - September 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Outcomes of Atlantoaxial Dislocation Combined with Osteoporosis Using Posterior Atlantoaxial Rod, Screw Fixation, and Posterior Interfacet Fusion: A Retrospective Study of 21 Cases.
CONCLUSIONS The results suggested that posterior atlantoaxial rod, screw fixation system, and posterior interfacet fusion could achieve satisfactory initial results for the treatment of atlantoaxial dislocation combined with osteoporosis. PMID: 32909549 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Carcinoid Tumorlets Co-Existing with Chronic Pulmonary Inflammatory Processes: Imaging Findings and Histological Appearances.
CONCLUSIONS PCT occurs most commonly in middle-aged women who have chronic pulmonary inflammatory processes such as bronchiectasis, atelectasis, and inflammation. Although there are no specific symptoms or direct imaging findings in these patients, our results showed that patients who have bronchiectasis, atelectasis, or recurrent pulmonary infection are at increased risk for PCT. PMID: 32913178 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Retrospective Study of the C-Reactive Protein to Lymphocyte Ratio and Disease Severity in 108 Patients with Early COVID-19 Pneumonia from January to March 2020 in Wuhan, China.
Authors: Yang M, Chen X, Xu Y Abstract BACKGROUND The aim of this study was to determine the effect of C-reactive protein (CRP), lymphocytes (LYM), and the ratio of CRP to LYM (CRP/LYM) on assessing the prognosis of COVID-19 severity at early stages of disease. MATERIAL AND METHODS A total of 108 hospitalized patients diagnosed with COVID-19 in Zhongnan Hospital of Wuhan University from January 17, 2020 to March 12, 2020 were enrolled. Data of demographic parameters, clinical characteristics, laboratory indicators, clinical manifestation, and outcome of disease were collected. The patients were divided into a sever...
Source: Medical Science Monitor - September 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Decreased Synovial Fluid Biomarkers Levels Are Associated with Rehabilitation of Function and Pain in Rotator Cuff Tear Patients Following Electroacupuncture Therapy.
Authors: Guan J, Geng WQ, Li Y, Liu GY, Ding LB, Liu YJ, Xue W, Wang H, Zheng XF Abstract BACKGROUND The aim of this study was to assess inflammatory cytokines levels in synovial fluid (SF) before and after electroacupuncture (EA) treatment and to explore whether these biomarkers are associated with function of rotator cuff tear (RCT) patients. MATERIAL AND METHODS We recruited 54 patients with RCT and separated them into an EA group and a control group. The SF biomarker levels were detected at baseline and at 6-week and 6-month follow-up. The symptomatic severity was evaluated by visual analog scale (VAS), Constan...
Source: Medical Science Monitor - September 12, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Characteristics of Injury Patients in the Emergency Department in Shanghai, China: A Retrospective Observational Study.
CONCLUSIONS Most trauma patients were young adults. Injuries due to traffic accidents and falling were the main causes of death, with disregard of driving regulations and other health and safety regulations being the main cause of trauma. Trauma injuries may be prevented by strengthening education and by obeying traffic laws and construction site safety regulations. PMID: 32900987 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Characteristics and Treatment Outcomes in Human Immunodeficiency Virus (HIV)-Infected Patients with Liver Abscess: A Retrospective Study of 53 Patients.
CONCLUSIONS Antibiotics plus image-guided percutaneous drainage can effectively improve treatment outcomes in HIV-infected patients with LA. PMID: 32901614 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Echo-Tracking Technique in Ultrasonography Can Monitor Changes in Carotid Artery Elastic Function at Early Stage of Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinoma.
CONCLUSIONS The present study demonstrates that the elastic function of the carotid artery can be significantly affected when the irradiation dose exceeds 45 Gy. PMID: 32903241 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Lower Metal Element Levels in Hypertrophic Scars: A Potential Mechanism of Aberrant Cicatrix Hyperplasia.
CONCLUSIONS Our findings indicate reduced levels of metal elements in part of the healing microenvironment, suggesting that decreased metal levels may be involved in the pathogenesis of HS. PMID: 32895361 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Overexpression of Linc 4930556M19Rik Suppresses High Glucose-Triggered Podocyte Apoptosis, Fibrosis and Inflammation via the miR-27a-3p/Metalloproteinase 3 (TIMP3) Axis in Diabetic Nephropathy.
CONCLUSIONS 4930556M19Rik overexpression slowed HG-induced podocyte injury by downregulating miR-27a-3p and upregulating TIMP3. PMID: 32896839 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Serum-Soluble ST2 Is a Novel Biomarker for Evaluating Left Atrial Low-Voltage Zone in Paroxysmal Atrial Fibrillation.
This study explored whether serum soluble ST2 (sST2) levels can predict the size of LVZs in patients with pAF. MATERIAL AND METHODS A total of 177 patients with pAF treated with RFCA were consecutively enrolled in this study. One hundred twenty-five patients (70.6%) with 20% were assigned to Group B. Levels of soluble ST2 (sST2), growth and differentiation factor (GDF-15) and tissue inhibitor of MMP1 (TIMP-1) were measured. RESULTS The sST2 levels were higher in Group B than in Group A (23.9±3.3 vs. 30.9±5.0 ng/mL, P
Source: Medical Science Monitor - September 10, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats.
Authors: Wang J, Gong X, Meng F, Deng S, Dai H, Bao B, Feng J, Li H, Wang B Abstract BACKGROUND The aim of this study was to explore the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) on spermatogenesis and the effects of the expression of related proteins. MATERIAL AND METHODS Rats in Group A were normoxic (exposed to a normal level of oxygen). Rats in Group B were exposed to intermittent hypoxia. After 6 weeks, the rats were killed and their epididymides were removed. The epididymis of one testis was used to test indices of semen quality. The epididymis of the other testis was stained with hematoxyli...
Source: Medical Science Monitor - September 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China.
Authors: Liu HW, Wei DX, He DW, Deng JZ, Zhu JJ, Xu K, Hu D, Li J, Hu WH, Wang Y, Xiao SH, Fu LG Abstract BACKGROUND The study aimed to explore the genetic association of Fc receptor-like 5 (FCRL5) gene variants (rs6427384 and rs6692977) with ankylosing spondylitis risk in Chinese Han population. MATERIAL AND METHODS Genotyping for FCRL5 gene variations rs6427384 and rs6692977 was implemented among 130 ankylosing spondylitis cases and 135 healthy persons, through polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Frequency dissimilarity for 2 polymorphisms was compared between 2 g...
Source: Medical Science Monitor - September 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Plasma β-Endorphin Concentration and Antipsychotic Treatment Outcome in Schizophrenia: 1-Year Follow-Up.
CONCLUSIONS Individuals with schizophrenia demonstrated higher BE concentrations than healthy controls; this tendency was particularly apparent in those affected by negative symptoms. The imbalance in the endogenous opioid system might adversely alter the course of disease and predispose patients to persistence of negative symptoms, despite antipsychotic treatment. PMID: 32892205 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Effect of Comorbidity on Outcomes of Patients with Advanced Non-Small Cell Lung Cancer Undergoing Anti-PD1 Immunotherapy.
Authors: Zeng X, Zhu S, Xu C, Wang Z, Su X, Zeng D, Long H, Zhu B Abstract BACKGROUND Comorbidities are reportedly related to the survival of patients with non-small cell lung cancer (NSCLC). The purpose of this study was to explore the impact of comorbidity, assessed by the Charlson comorbidity index (CCI) and the simplified comorbidity scores (SCS) on clinical outcomes of patients with NSCLC treated with immune checkpoint inhibitors. MATERIAL AND METHODS Sixty-six patients with NSCLC who received programmed cell death protein 1 (PD1) inhibitors in our institution in the past 2 years were enrolled in this retrospe...
Source: Medical Science Monitor - September 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin's Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells.
CONCLUSIONS Curcumin negatively regulated transcription factors promoting EMT in CRC cells by decreasing cdx2 promoter DNA methylation and consequently suppressing the CDX2/Wnt3a/ß-catenin signaling pathway. PMID: 32893845 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Composite Tissue Engineered Bone Material Consisting of Bone Mesenchymal Stem Cells, Bone Morphogenetic Protein 9 (BMP9) Gene Lentiviral Vector, and P3HB4HB Thermogel (BMSCs-LV-BMP9-P3HB4HB) Repairs Calvarial Skull Defects in Rats by Expression of Osteogenic Factors.
This study aimed to investigate the effects and mechanism of a composite tissue engineered bone material consisting of bone mesenchymal stem cells (BMSCs), bone morphogenetic protein (BMP9) gene lentiviral vector, and P3HB4HB thermogel (BMSCs-LV-BMP9-P3HB4HB) on calvarial skull defects in rats. MATERIAL AND METHODS LV-BMP9 viral vector was structured and infected to BMSCs-P3HB4HB composite scaffold, which was named as BMSCs-P3HB4HB composite bone repair material. Adipogenic differentiation was determined by oil-red O (ORO) and alkaline phosphatase (ALP) staining. Osteogenic differentiation was measured using Alizarin red s...
Source: Medical Science Monitor - September 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Diagnostic Value of Magnetic Resonance (MR) Combined with Computed Tomography (CT) in Patients with Stress Injury of Femoral Neck.
Authors: Chen J, Zheng S, Song Q, Liu A Abstract BACKGROUND The purpose of this research was to study and analyze the diagnostic value of magnetic resonance (MR) combined with computed tomography (CT) in patients with stress injury of the femoral neck. MATERIAL AND METHODS The 58 patients with stress injury of the femoral neck who were treated in our hospital from July 2017 until July 2019 were selected as subjects on the basis of clinical pathology and surgery, MR and CT examination, and related imaging data retrospectively analyzed. We observed all patients using different diagnostic methods to determine the valu...
Source: Medical Science Monitor - September 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Identification of Hub Genes Associated with Hypertension and Their Interaction with miRNA Based on Weighted Gene Coexpression Network Analysis (WGCNA) Analysis.
CONCLUSIONS These findings will help improve the understanding of the pathogenesis of hypertension, and the discovered genes can serve as signatures for early diagnosis of hypertension. PMID: 32888289 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Diagnostic Model to Improve the Predictability of Natural Pregnancy Potential in Patients with Oligoasthenospermia.
CONCLUSIONS This comprehensive clinical prediction model can be used to determine whether infertile oligoasthenospermia patients lack natural fertility. PMID: 32890392 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 7, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Long Non-Coding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Cell Proliferation and Migration by Regulating miR-143-3p and MAGE Family Member A9 (MAGEA9) in Oral Squamous Cell Carcinoma.
CONCLUSIONS Taken together, our results suggest that MALAT1 functions as a competing endogenous RNA (ceRNA) in promoting OSCC cell proliferation and migration abilities through the miR-143-3p/MAGEA9 axis, thus providing new therapeutic targets for treatment of OSCC. PMID: 32879299 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-kB)-Dependent Pathway.
CONCLUSIONS Our results showed that the CXCL12/CXCR4 and EGF/EGFR axis can regulate the expression of each other through the NF-kappaB pathway to promote metastasis. These data suggested that simultaneous inhibition of EGFR and CXCR4 may be a potential therapeutic strategy in gastric cancer. PMID: 32881844 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Clinical Characteristics and Outcomes of Patients with Severe COVID-19 and Chronic Obstructive Pulmonary Disease (COPD).
CONCLUSIONS COPD increases the risks of death and negative outcomes in patients with severe COVID-19. PMID: 32883943 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Icariin Protects Mouse Insulinoma Min6 Cell Function by Activating the PI3K/AKT Pathway.
CONCLUSIONS ICA protected Min6 cell function, an effect likely mediated by the PI3K pathway. ICA may inhibit the progression of diabetes. PMID: 32885795 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Individualized Running Wheel System with a Dynamically Adjustable Exercise Area and Speed for Rats Following Ischemic Stroke.
CONCLUSIONS The outcomes of the rats that were rehabilitated using the newly designed training system were better than those of their control-group counterparts, indicating the advantages of this designed system. PMID: 32886655 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 5, 2020 Category: Research Tags: Med Sci Monit Source Type: research

A Novel Risk Model Based on Autophagy Pathway Related Genes for Survival Prediction in Lung Adenocarcinoma.
Authors: Zhang F, Xie S, Zhang Z, Zhao H, Zhao Z, Sun H, Zheng J Abstract BACKGROUND Autophagy has a principal role in mediating tumor cell metabolism. However, the role of autophagy-pathway-related genes (APRGs) as prognostic markers remains obscure in lung adenocarcinoma (LUAD). More potential prognostic biomarkers are needed to deepen our understanding to explore the prognostic role of APRGs in LUAD. MATERIAL AND METHODS We used The Cancer Genome Atlas (TCGA) database to identify differentially expressed APRGs. Cox proportional hazard regression was used to identify prognostic APRGs, and then a risk model was co...
Source: Medical Science Monitor - September 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Clinical Characteristics, Pathological Changes and Changes of Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Children with Castleman's Disease.
Authors: Hu C, Zou Y, Pan J, Yang J, Yang T, Tan T, Li J Abstract BACKGROUND The aim of this study was to analyze the pathological changes, clinical characteristics and changes in immunity, interleukin-6 (IL-6) and C-reactive protein (CRP) in children with Castleman's disease (CD). MATERIAL AND METHODS A total of 15 CD child patients were enrolled as observation group, while 20 normal children receiving healthy examination were enrolled as healthy control group. The pathological changes, clinical characteristics and changes in immunity and serum IL-6 and CRP expressions were retrospectively analyzed in observation ...
Source: Medical Science Monitor - September 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

miR-22-3p Suppresses Endothelial Progenitor Cell Proliferation and Migration via Inhibiting Onecut 1 (OC1)/Vascular Endothelial Growth Factor A (VEGFA) Signaling Pathway and Its Clinical Significance in Venous Thrombosis.
CONCLUSIONS Our results suggest that miR-22-3p regulates OC1/VEGFA signaling and is involved in regulating EPC proliferation and migration. The expression level of miR-22-3p could be monitored to predict DVT patients' prognosis. PMID: 32876075 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Value of Angioembolization in the Treatment of Iatrogenic Renal Vascular Injury Assisted by 3-Dimensional Digital Subtraction Angiography.
CONCLUSIONS Proximal embolization technique assisted by 3D-DSA for renal iatrogenic hemorrhage and vascular lesions is both safe and efficacious, offering high rates for both clinical and technical success. It maximizes the protection of the kidney and reduces the rate of renal resection. PMID: 32877388 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 4, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Chlorogenic Acid Alleviates Allergic Inflammatory Responses Through Regulating Th1/Th2 Balance in Ovalbumin-Induced Allergic Rhinitis Mice.
CONCLUSIONS CGA can alleviate allergic inflammatory responses through regulating Th1/Th2 balance in OVA-induced allergic rhinitis mice. PMID: 32868754 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - September 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Impact of COVID-19 on Emotional Resilience and Learning Management of Middle School Students.
This study used a survey to explore emotional resilience and learning management abilities in middle school students (N=896) from February 10, 2020, to March 22, 2020. Students used online e-learning during this period due to the COVID-19 pandemic. Data were analyzed using t-testing, Pearson's correlation, and multivariate linear regression. RESULTS The results indicate that emotional resilience was significantly lower in eighth grade students than in seventh grade students (t=1.98, P
Source: Medical Science Monitor - September 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2.
This study aimed to explore effects of atorvastatin on colony formation of PCa cells and radio-resistance of xenograft tumor models. MATERIAL AND METHODS PCa cell lines, including PC3, DU145, and Lncap, were treated with irradiation (4 Gy) and/or atorvastatin (6 μg/mL). Cells were divided into tumor cell group, irradiation treatment group (IR group) and irradiation+atorvastatin treatment group (IR-AS group). Xenograft tumor mouse model was established. Plate clone formation assay (multi-target/single-hit model) was conducted to evaluate colony formation. Flow cytometry analysis was employed to detect apoptosis. Interact...
Source: Medical Science Monitor - September 2, 2020 Category: Research Tags: Med Sci Monit Source Type: research